5CQ2A

Crystal structure of tandem ww domains of itch in complex with txnip peptide
Total Genus 11
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
11
sequence length
80
structure length
76
Chain Sequence
GPLPPGWEKRTDSNGRVYFVNHNTRITQWEDPRSQEKPLPEGWEMRFTVDGIPYFVDHNRRTTTYIDPRTGKSALD
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural basis for the regulatory role of the PPxY motifs in the thioredoxin-interacting protein TXNIP.
pubmed doi rcsb
molecule keywords E3 ubiquitin-protein ligase Itchy homolog
molecule tags Ligase
source organism Homo sapiens
total genus 11
structure length 76
sequence length 80
ec nomenclature ec 2.3.2.26: HECT-type E3 ubiquitin transferase.
pdb deposition date 2015-07-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00397 WW WW domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.20.70.10 Mainly Beta Single Sheet Ubiquitin Ligase Nedd4; Chain: W; Ubiquitin Ligase Nedd4; Chain: W; 5cq2A02
2M8IA 3M7NA 2DMVA 2XP8A 3KAHA 2MDIA 1EG4A 2ZR5A 3KCEA 1TK7A 2DK7A 3KAGA 2YSBA 2Q5AA 2ZQVA 1WR7A 3KABA 2EZ5W 2JXWA 2XP5A 2DJYA 1F8AB 2M8JA 2XP7A 3M85A 2YSHA 4E5RA 1JMQA 2F21A 3WH0A 2XPAA 4U85A 2ZQUA 2RE3A 1WMVA 4U86A 2DK1A 2ZQSA 2ZR4A 3LE4A 1K9QA 4U84A 3TC5A 1O6WA 2YSGA 2XP6A 1NMVA 2E45A 2LAJA 3CNGA 2XPBA 1K9RA 5CQ2A 2ZAJA 3TDBA 1ZCNA 2ITKA 2DWVA 2BA1A 4REXA 2XP3A 3OOBA 3KADA 2ZR6A 1YW5A 3NTPA 2L4JA 2M3OW 2JX8A 3KAIA 3ODKA 2XP4A 2XP9A 2YSFA 2YSIA 1I5HW 3KAFA 2KXQA 2JMFA 5AHTA 3TCZA 3L4HA 1EG3A 1PINA 2ZQTA 4QIBA 2JV4A
chains in the Genus database with same CATH superfamily
2M8IA 2WAEA 3M7NA 2DMVA 2XP8A 4A0TA 2OWOA 3KAHA 2MDIA 1EG4A 4QIBA 2ZR5A 3KCEA 1TK7A 2DK7A 3KAGA 1TR8A 4A0UA 2YSBA 3LKXB 2Q5AA 2ZQVA 1WR7A 3KABA 2EZ5W 2JXWA 2XP5A 2DJYA 1F8AB 1RP5A 3PQHA 2M8JA 2XP7A 3M85A 3MQGA 2YSHA 3MCBB 3MQHA 4E5RA 1JMQA 2F21A 3WH0A 5U47A 2XPAA 4U85A 5E65A 2ZQUA 2RE3A 1WMVA 4U86A 2DK1A 2ZQSA 2ZR4A 3LE4A 2YAJB 1K9QA 4U84A 3TC5A 1O6WA 2YSGA 5E5WA 2XP6A 1NMVA 2E45A 2LAJA 3CNGA 2XPBA 3FSCA 1K9RA 2QRVA 5CQ2A 2ZAJA 3LKXA 3TDBA 5E62A 1ZCNA 2ITKA 2DWVA 2BA1A 4REXA 2XP3A 3OOBA 2Y8NB 3KADA 3FSBA 1YW5A 3NTPA 2L4JA 2M3OW 3FS8A 4GLXA 2JX8A 3KAIA 3ODKA 5E66A 1FLCA 2XP4A 5E64A 2XP9A 2YSFA 2YSIA 1I5HW 3KAFA 2KXQA 2JMFA 5AHTA 3TCZA 3MCBA 3L4HA 1EG3A 2WADA 1PINA 2ZQTA 2ZR6A 2JV4A
chains in the Genus database with same CATH topology
2M8IA 2WAEA 3M7NA 2DMVA 2XP8A 4A0TA 2OWOA 3KAHA 2MDIA 1EG4A 4QIBA 2ZR5A 3KCEA 1TK7A 2DK7A 3KAGA 1TR8A 4A0UA 2YSBA 3LKXB 2Q5AA 2ZQVA 1WR7A 3KABA 2EZ5W 2JXWA 2XP5A 2DJYA 1F8AB 1RP5A 3PQHA 2M8JA 2XP7A 3M85A 3MQGA 2YSHA 3MCBB 3MQHA 4E5RA 1JMQA 2F21A 3WH0A 5U47A 2XPAA 4U85A 5E65A 2ZQUA 2RE3A 1WMVA 4U86A 2DK1A 2ZQSA 2ZR4A 3LE4A 2YAJB 1K9QA 4U84A 3TC5A 1O6WA 2YSGA 5E5WA 2XP6A 1NMVA 2E45A 2LAJA 3CNGA 2XPBA 3FSCA 1K9RA 2QRVA 5CQ2A 2ZAJA 3LKXA 3TDBA 5E62A 1ZCNA 2ITKA 2DWVA 2BA1A 4REXA 2XP3A 3OOBA 2Y8NB 3KADA 3FSBA 1YW5A 3NTPA 2L4JA 2M3OW 3FS8A 4GLXA 2JX8A 3KAIA 3ODKA 5E66A 1FLCA 2XP4A 5E64A 2XP9A 2YSFA 2YSIA 1I5HW 3KAFA 2KXQA 2JMFA 5AHTA 3TCZA 3MCBA 3L4HA 1EG3A 2WADA 1PINA 2ZQTA 2ZR6A 2JV4A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2M8I A;  3M7N A;  2DMV A;  2XP8 A;  3KAH A;  2MDI A;  1EG4 A;  2ZR5 A;  3KCE A;  1TK7 A;  2DK7 A;  3KAG A;  2YSB A;  2Q5A A;  2ZQV A;  1WR7 A;  3KAB A;  2EZ5 W;  2JXW A;  2XP5 A;  2DJY A;  1F8A B;  2M8J A;  2XP7 A;  3M85 A;  2YSH A;  4E5R A;  1JMQ A;  2F21 A;  3WH0 A;  2XPA A;  4U85 A;  2ZQU A;  2RE3 A;  1WMV A;  4U86 A;  2DK1 A;  2ZQS A;  2ZR4 A;  3LE4 A;  1K9Q A;  4U84 A;  3TC5 A;  1O6W A;  2YSG A;  2XP6 A;  1NMV A;  2E45 A;  2LAJ A;  3CNG A;  2XPB A;  1K9R A;  5CQ2 A;  2ZAJ A;  3TDB A;  1ZCN A;  2ITK A;  2DWV A;  2BA1 A;  4REX A;  2XP3 A;  3OOB A;  3KAD A;  2ZR6 A;  1YW5 A;  3NTP A;  2L4J A;  2M3O W;  2JX8 A;  3KAI A;  3ODK A;  2XP4 A;  2XP9 A;  2YSF A;  2YSI A;  1I5H W;  3KAF A;  2KXQ A;  2JMF A;  5AHT A;  3TCZ A;  3L4H A;  1EG3 A;  1PIN A;  2ZQT A;  4QIB A;  2JV4 A; 
#chains in the Genus database with same CATH topology
 2M8I A;  2WAE A;  3M7N A;  2DMV A;  2XP8 A;  4A0T A;  2OWO A;  3KAH A;  2MDI A;  1EG4 A;  4QIB A;  2ZR5 A;  3KCE A;  1TK7 A;  2DK7 A;  3KAG A;  1TR8 A;  4A0U A;  2YSB A;  3LKX B;  2Q5A A;  2ZQV A;  1WR7 A;  3KAB A;  2EZ5 W;  2JXW A;  2XP5 A;  2DJY A;  1F8A B;  1RP5 A;  3PQH A;  2M8J A;  2XP7 A;  3M85 A;  3MQG A;  2YSH A;  3MCB B;  3MQH A;  4E5R A;  1JMQ A;  2F21 A;  3WH0 A;  5U47 A;  2XPA A;  4U85 A;  5E65 A;  2ZQU A;  2RE3 A;  1WMV A;  4U86 A;  2DK1 A;  2ZQS A;  2ZR4 A;  3LE4 A;  2YAJ B;  1K9Q A;  4U84 A;  3TC5 A;  1O6W A;  2YSG A;  5E5W A;  2XP6 A;  1NMV A;  2E45 A;  2LAJ A;  3CNG A;  2XPB A;  3FSC A;  1K9R A;  2QRV A;  5CQ2 A;  2ZAJ A;  3LKX A;  3TDB A;  5E62 A;  1ZCN A;  2ITK A;  2DWV A;  2BA1 A;  4REX A;  2XP3 A;  3OOB A;  2Y8N B;  3KAD A;  3FSB A;  1YW5 A;  3NTP A;  2L4J A;  2M3O W;  3FS8 A;  4GLX A;  2JX8 A;  3KAI A;  3ODK A;  5E66 A;  1FLC A;  2XP4 A;  5E64 A;  2XP9 A;  2YSF A;  2YSI A;  1I5H W;  3KAF A;  2KXQ A;  2JMF A;  5AHT A;  3TCZ A;  3MCB A;  3L4H A;  1EG3 A;  2WAD A;  1PIN A;  2ZQT A;  2ZR6 A;  2JV4 A; 
#chains in the Genus database with same CATH homology
 2M8I A;  2WAE A;  3M7N A;  2DMV A;  2XP8 A;  4A0T A;  2OWO A;  3KAH A;  2MDI A;  1EG4 A;  4QIB A;  2ZR5 A;  3KCE A;  1TK7 A;  2DK7 A;  3KAG A;  1TR8 A;  4A0U A;  2YSB A;  3LKX B;  2Q5A A;  2ZQV A;  1WR7 A;  3KAB A;  2EZ5 W;  2JXW A;  2XP5 A;  2DJY A;  1F8A B;  1RP5 A;  3PQH A;  2M8J A;  2XP7 A;  3M85 A;  3MQG A;  2YSH A;  3MCB B;  3MQH A;  4E5R A;  1JMQ A;  2F21 A;  3WH0 A;  5U47 A;  2XPA A;  4U85 A;  5E65 A;  2ZQU A;  2RE3 A;  1WMV A;  4U86 A;  2DK1 A;  2ZQS A;  2ZR4 A;  3LE4 A;  2YAJ B;  1K9Q A;  4U84 A;  3TC5 A;  1O6W A;  2YSG A;  5E5W A;  2XP6 A;  1NMV A;  2E45 A;  2LAJ A;  3CNG A;  2XPB A;  3FSC A;  1K9R A;  2QRV A;  5CQ2 A;  2ZAJ A;  3LKX A;  3TDB A;  5E62 A;  1ZCN A;  2ITK A;  2DWV A;  2BA1 A;  4REX A;  2XP3 A;  3OOB A;  2Y8N B;  3KAD A;  3FSB A;  1YW5 A;  3NTP A;  2L4J A;  2M3O W;  3FS8 A;  4GLX A;  2JX8 A;  3KAI A;  3ODK A;  5E66 A;  1FLC A;  2XP4 A;  5E64 A;  2XP9 A;  2YSF A;  2YSI A;  1I5H W;  3KAF A;  2KXQ A;  2JMF A;  5AHT A;  3TCZ A;  3MCB A;  3L4H A;  1EG3 A;  2WAD A;  1PIN A;  2ZQT A;  2ZR6 A;  2JV4 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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