5CQ2A

Crystal structure of tandem ww domains of itch in complex with txnip peptide
Total Genus 11
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
11
sequence length
80
structure length
76
Chain Sequence
GPLPPGWEKRTDSNGRVYFVNHNTRITQWEDPRSQEKPLPEGWEMRFTVDGIPYFVDHNRRTTTYIDPRTGKSALD
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural basis for the regulatory role of the PPxY motifs in the thioredoxin-interacting protein TXNIP.
pubmed doi rcsb
molecule keywords E3 ubiquitin-protein ligase Itchy homolog
molecule tags Ligase
source organism Homo sapiens
total genus 11
structure length 76
sequence length 80
ec nomenclature ec 2.3.2.26: HECT-type E3 ubiquitin transferase.
pdb deposition date 2015-07-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00397 WW WW domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.20.70.10 Mainly Beta Single Sheet Ubiquitin Ligase Nedd4; Chain: W; Ubiquitin Ligase Nedd4; Chain: W; 5cq2A02
2XP4A 2YSHA 2YSGA 4QIBA 3TCZA 2E45A 3L4HA 2ZQUA 2EZ5W 2ZQTA 2M8IA 2Q5AA 2BA1A 2ZQVA 1EG3A 1NMVA 5AHTA 2ZQSA 3KCEA 2JMFA 2ITKA 2JV4A 3LE4A 3CNGA 2XP9A 1JMQA 3WH0A 3KABA 3KAGA 2RE3A 2DMVA 2YSBA 3TDBA 3NTPA 4U85A 2M3OW 1PINA 2DK1A 1F8AB 3M85A 3KAIA 2DJYA 2XP6A 1TK7A 3KAHA 1WMVA 2F21A 2XPAA 2MDIA 3TC5A 1ZCNA 1K9RA 2YSFA 2JXWA 5CQ2A 3OOBA 2ZR5A 2M8JA 2ZAJA 4U86A 3KAFA 2DWVA 2XP7A 3M7NA 1WR7A 3KADA 2ZR6A 1I5HW 2JX8A 2XP5A 2DK7A 4REXA 4E5RA 2XPBA 2L4JA 1O6WA 1YW5A 4U84A 2XP8A 2YSIA 2LAJA 2XP3A 2KXQA 1EG4A 2ZR4A 3ODKA 1K9QA
chains in the Genus database with same CATH superfamily
2XP4A 2YSHA 3LKXB 2YSGA 4QIBA 3TCZA 2E45A 3L4HA 2ZQUA 2EZ5W 5E66A 2ZQTA 2M8IA 3FSBA 2Q5AA 2BA1A 2ZQVA 1EG3A 1RP5A 2Y8NB 3MCBA 1NMVA 5AHTA 2ZQSA 3KCEA 2JMFA 2ITKA 2JV4A 3LE4A 3CNGA 2XP9A 1JMQA 3WH0A 3FSCA 4GLXA 3KABA 3KAGA 2RE3A 2DMVA 2YSBA 1FLCA 3TDBA 5U47A 3NTPA 4U85A 2M3OW 2OWOA 1PINA 2DK1A 1F8AB 3M85A 3KAIA 2DJYA 2XP6A 1TK7A 3KAHA 3MQHA 1WMVA 2F21A 2XPAA 3MCBB 2MDIA 2YAJB 3LKXA 5E64A 3TC5A 1ZCNA 1K9RA 2YSFA 2JXWA 5CQ2A 5E65A 3OOBA 2ZR5A 2M8JA 2ZAJA 4U86A 3KAFA 2DWVA 3FS8A 2XP7A 5E5WA 3M7NA 1WR7A 4A0UA 3KADA 2ZR6A 1I5HW 5E62A 2JX8A 2XP5A 4A0TA 2DK7A 4REXA 4E5RA 2XPBA 3MQGA 2L4JA 3PQHA 2WADA 1O6WA 1YW5A 4U84A 2XP8A 2YSIA 2LAJA 2XP3A 2WAEA 2KXQA 2QRVA 1EG4A 2ZR4A 3ODKA 1K9QA 1TR8A
chains in the Genus database with same CATH topology
2XP4A 2YSHA 3LKXB 2YSGA 4QIBA 3TCZA 2E45A 3L4HA 2ZQUA 2EZ5W 5E66A 2ZQTA 2M8IA 3FSBA 2Q5AA 2BA1A 2ZQVA 1EG3A 1RP5A 2Y8NB 3MCBA 1NMVA 5AHTA 2ZQSA 3KCEA 2JMFA 2ITKA 2JV4A 3LE4A 3CNGA 2XP9A 1JMQA 3WH0A 3FSCA 4GLXA 3KABA 3KAGA 2RE3A 2DMVA 2YSBA 1FLCA 3TDBA 5U47A 3NTPA 4U85A 2M3OW 2OWOA 1PINA 2DK1A 1F8AB 3M85A 3KAIA 2DJYA 2XP6A 1TK7A 3KAHA 3MQHA 1WMVA 2F21A 2XPAA 3MCBB 2MDIA 2YAJB 3LKXA 5E64A 3TC5A 1ZCNA 1K9RA 2YSFA 2JXWA 5CQ2A 5E65A 3OOBA 2ZR5A 2M8JA 2ZAJA 4U86A 3KAFA 2DWVA 3FS8A 2XP7A 5E5WA 3M7NA 1WR7A 4A0UA 3KADA 2ZR6A 1I5HW 5E62A 2JX8A 2XP5A 4A0TA 2DK7A 4REXA 4E5RA 2XPBA 3MQGA 2L4JA 3PQHA 2WADA 1O6WA 1YW5A 4U84A 2XP8A 2YSIA 2LAJA 2XP3A 2WAEA 2KXQA 2QRVA 1EG4A 2ZR4A 3ODKA 1K9QA 1TR8A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2XP4 A;  2YSH A;  2YSG A;  4QIB A;  3TCZ A;  2E45 A;  3L4H A;  2ZQU A;  2EZ5 W;  2ZQT A;  2M8I A;  2Q5A A;  2BA1 A;  2ZQV A;  1EG3 A;  1NMV A;  5AHT A;  2ZQS A;  3KCE A;  2JMF A;  2ITK A;  2JV4 A;  3LE4 A;  3CNG A;  2XP9 A;  1JMQ A;  3WH0 A;  3KAB A;  3KAG A;  2RE3 A;  2DMV A;  2YSB A;  3TDB A;  3NTP A;  4U85 A;  2M3O W;  1PIN A;  2DK1 A;  1F8A B;  3M85 A;  3KAI A;  2DJY A;  2XP6 A;  1TK7 A;  3KAH A;  1WMV A;  2F21 A;  2XPA A;  2MDI A;  3TC5 A;  1ZCN A;  1K9R A;  2YSF A;  2JXW A;  5CQ2 A;  3OOB A;  2ZR5 A;  2M8J A;  2ZAJ A;  4U86 A;  3KAF A;  2DWV A;  2XP7 A;  3M7N A;  1WR7 A;  3KAD A;  2ZR6 A;  1I5H W;  2JX8 A;  2XP5 A;  2DK7 A;  4REX A;  4E5R A;  2XPB A;  2L4J A;  1O6W A;  1YW5 A;  4U84 A;  2XP8 A;  2YSI A;  2LAJ A;  2XP3 A;  2KXQ A;  1EG4 A;  2ZR4 A;  3ODK A;  1K9Q A; 
#chains in the Genus database with same CATH topology
 2XP4 A;  2YSH A;  3LKX B;  2YSG A;  4QIB A;  3TCZ A;  2E45 A;  3L4H A;  2ZQU A;  2EZ5 W;  5E66 A;  2ZQT A;  2M8I A;  3FSB A;  2Q5A A;  2BA1 A;  2ZQV A;  1EG3 A;  1RP5 A;  2Y8N B;  3MCB A;  1NMV A;  5AHT A;  2ZQS A;  3KCE A;  2JMF A;  2ITK A;  2JV4 A;  3LE4 A;  3CNG A;  2XP9 A;  1JMQ A;  3WH0 A;  3FSC A;  4GLX A;  3KAB A;  3KAG A;  2RE3 A;  2DMV A;  2YSB A;  1FLC A;  3TDB A;  5U47 A;  3NTP A;  4U85 A;  2M3O W;  2OWO A;  1PIN A;  2DK1 A;  1F8A B;  3M85 A;  3KAI A;  2DJY A;  2XP6 A;  1TK7 A;  3KAH A;  3MQH A;  1WMV A;  2F21 A;  2XPA A;  3MCB B;  2MDI A;  2YAJ B;  3LKX A;  5E64 A;  3TC5 A;  1ZCN A;  1K9R A;  2YSF A;  2JXW A;  5CQ2 A;  5E65 A;  3OOB A;  2ZR5 A;  2M8J A;  2ZAJ A;  4U86 A;  3KAF A;  2DWV A;  3FS8 A;  2XP7 A;  5E5W A;  3M7N A;  1WR7 A;  4A0U A;  3KAD A;  2ZR6 A;  1I5H W;  5E62 A;  2JX8 A;  2XP5 A;  4A0T A;  2DK7 A;  4REX A;  4E5R A;  2XPB A;  3MQG A;  2L4J A;  3PQH A;  2WAD A;  1O6W A;  1YW5 A;  4U84 A;  2XP8 A;  2YSI A;  2LAJ A;  2XP3 A;  2WAE A;  2KXQ A;  2QRV A;  1EG4 A;  2ZR4 A;  3ODK A;  1K9Q A;  1TR8 A; 
#chains in the Genus database with same CATH homology
 2XP4 A;  2YSH A;  3LKX B;  2YSG A;  4QIB A;  3TCZ A;  2E45 A;  3L4H A;  2ZQU A;  2EZ5 W;  5E66 A;  2ZQT A;  2M8I A;  3FSB A;  2Q5A A;  2BA1 A;  2ZQV A;  1EG3 A;  1RP5 A;  2Y8N B;  3MCB A;  1NMV A;  5AHT A;  2ZQS A;  3KCE A;  2JMF A;  2ITK A;  2JV4 A;  3LE4 A;  3CNG A;  2XP9 A;  1JMQ A;  3WH0 A;  3FSC A;  4GLX A;  3KAB A;  3KAG A;  2RE3 A;  2DMV A;  2YSB A;  1FLC A;  3TDB A;  5U47 A;  3NTP A;  4U85 A;  2M3O W;  2OWO A;  1PIN A;  2DK1 A;  1F8A B;  3M85 A;  3KAI A;  2DJY A;  2XP6 A;  1TK7 A;  3KAH A;  3MQH A;  1WMV A;  2F21 A;  2XPA A;  3MCB B;  2MDI A;  2YAJ B;  3LKX A;  5E64 A;  3TC5 A;  1ZCN A;  1K9R A;  2YSF A;  2JXW A;  5CQ2 A;  5E65 A;  3OOB A;  2ZR5 A;  2M8J A;  2ZAJ A;  4U86 A;  3KAF A;  2DWV A;  3FS8 A;  2XP7 A;  5E5W A;  3M7N A;  1WR7 A;  4A0U A;  3KAD A;  2ZR6 A;  1I5H W;  5E62 A;  2JX8 A;  2XP5 A;  4A0T A;  2DK7 A;  4REX A;  4E5R A;  2XPB A;  3MQG A;  2L4J A;  3PQH A;  2WAD A;  1O6W A;  1YW5 A;  4U84 A;  2XP8 A;  2YSI A;  2LAJ A;  2XP3 A;  2WAE A;  2KXQ A;  2QRV A;  1EG4 A;  2ZR4 A;  3ODK A;  1K9Q A;  1TR8 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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