2DMVA

Solution structure of the second ww domain of itchy homolog e3 ubiquitin protein ligase (itch)
Total Genus 3
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
3
sequence length
43
structure length
43
Chain Sequence
GSSGSSGLPPGWEQRVDQHGRVYYVDHVEKRTTWDRPSGPSSG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Solution structure of the second ww domain of Itchy homolog E3 ubiquitin protein ligase (Itch)
rcsb
molecule tags Ligase
source organism Homo sapiens
molecule keywords Itchy homolog E3 ubiquitin protein ligase
total genus 3
structure length 43
sequence length 43
ec nomenclature ec 2.3.2.26: HECT-type E3 ubiquitin transferase.
pdb deposition date 2006-04-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00397 WW WW domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.20.70.10 Mainly Beta Single Sheet Ubiquitin Ligase Nedd4; Chain: W; Ubiquitin Ligase Nedd4; Chain: W; 2dmvA01
1I5HW 2ZQSA 4U84A 2M8JA 3ODKA 2JXWA 3KAFA 1EG4A 4QIBA 4REXA 3KAIA 2JV4A 2MDIA 2YSIA 1K9RA 2RE3A 2XP5A 1EG3A 4U86A 2JX8A 1ZCNA 2M3OW 2YSHA 3OOBA 2BA1A 2XP7A 2Q5AA 2ZQTA 1YW5A 3WH0A 3L4HA 2ZR4A 2JMFA 1WMVA 2YSGA 4E5RA 2XP9A 1PINA 1K9QA 2XPAA 2XP6A 2E45A 2DK1A 3TC5A 1WR7A 3KABA 1F8AB 2ZR6A 1NMVA 2ZR5A 3KAGA 1JMQA 2ITKA 2ZQUA 3M85A 2DJYA 2F21A 2XP4A 3KADA 1O6WA 3TCZA 5AHTA 2YSBA 2LAJA 2XPBA 3M7NA 2ZQVA 2ZAJA 3LE4A 4U85A 2DK7A 2EZ5W 2DMVA 3NTPA 2XP3A 1TK7A 2YSFA 2DWVA 5CQ2A 2M8IA 3CNGA 2XP8A 2KXQA 3TDBA 3KAHA 2L4JA 3KCEA
chains in the Genus database with same CATH superfamily
1I5HW 2ZQSA 4U84A 2M8JA 3ODKA 2JXWA 3KAFA 5E64A 1EG4A 5E65A 4QIBA 4REXA 3KAIA 2JV4A 2MDIA 2YSIA 1K9RA 2RE3A 2XP5A 1EG3A 5U47A 4U86A 2JX8A 3PQHA 1ZCNA 2M3OW 4GLXA 2YSHA 3OOBA 2BA1A 2QRVA 1FLCA 2XP7A 2Q5AA 2ZQTA 4A0TA 1YW5A 3MQHA 3WH0A 4A0UA 3L4HA 2ZR4A 2JMFA 3FSBA 2WAEA 1WMVA 2YSGA 4E5RA 3LKXB 2XP9A 1PINA 1K9QA 2XPAA 2XP6A 2E45A 3MQGA 2OWOA 5E62A 2DK1A 3TC5A 1RP5A 1WR7A 3FS8A 3FSCA 1F8AB 3KABA 2ZR6A 1NMVA 2ZR5A 3KAGA 2Y8NB 3MCBB 5E5WA 1JMQA 2ITKA 2ZQUA 3M85A 2DJYA 2YAJB 2F21A 2XP4A 3KADA 1O6WA 3TCZA 5AHTA 3LKXA 2YSBA 2LAJA 2XPBA 3M7NA 2ZQVA 2ZAJA 3LE4A 4U85A 2DK7A 2EZ5W 2DMVA 3NTPA 2XP3A 1TK7A 2YSFA 2DWVA 1TR8A 5CQ2A 2M8IA 3CNGA 3MCBA 2WADA 2XP8A 2KXQA 3TDBA 3KAHA 2L4JA 3KCEA 5E66A
chains in the Genus database with same CATH topology
1I5HW 2ZQSA 4U84A 2M8JA 3ODKA 2JXWA 3KAFA 5E64A 1EG4A 5E65A 4QIBA 4REXA 3KAIA 2JV4A 2MDIA 2YSIA 1K9RA 2RE3A 2XP5A 1EG3A 5U47A 4U86A 2JX8A 3PQHA 1ZCNA 2M3OW 4GLXA 2YSHA 3OOBA 2BA1A 2QRVA 1FLCA 2XP7A 2Q5AA 2ZQTA 4A0TA 1YW5A 3MQHA 3WH0A 4A0UA 3L4HA 2ZR4A 2JMFA 3FSBA 2WAEA 1WMVA 2YSGA 4E5RA 3LKXB 2XP9A 1PINA 1K9QA 2XPAA 2XP6A 2E45A 3MQGA 2OWOA 5E62A 2DK1A 3TC5A 1RP5A 1WR7A 3FS8A 3FSCA 1F8AB 3KABA 2ZR6A 1NMVA 2ZR5A 3KAGA 2Y8NB 3MCBB 5E5WA 1JMQA 2ITKA 2ZQUA 3M85A 2DJYA 2YAJB 2F21A 2XP4A 3KADA 1O6WA 3TCZA 5AHTA 3LKXA 2YSBA 2LAJA 2XPBA 3M7NA 2ZQVA 2ZAJA 3LE4A 4U85A 2DK7A 2EZ5W 2DMVA 3NTPA 2XP3A 1TK7A 2YSFA 2DWVA 1TR8A 5CQ2A 2M8IA 3CNGA 3MCBA 2WADA 2XP8A 2KXQA 3TDBA 3KAHA 2L4JA 3KCEA 5E66A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1I5H W;  2ZQS A;  4U84 A;  2M8J A;  3ODK A;  2JXW A;  3KAF A;  1EG4 A;  4QIB A;  4REX A;  3KAI A;  2JV4 A;  2MDI A;  2YSI A;  1K9R A;  2RE3 A;  2XP5 A;  1EG3 A;  4U86 A;  2JX8 A;  1ZCN A;  2M3O W;  2YSH A;  3OOB A;  2BA1 A;  2XP7 A;  2Q5A A;  2ZQT A;  1YW5 A;  3WH0 A;  3L4H A;  2ZR4 A;  2JMF A;  1WMV A;  2YSG A;  4E5R A;  2XP9 A;  1PIN A;  1K9Q A;  2XPA A;  2XP6 A;  2E45 A;  2DK1 A;  3TC5 A;  1WR7 A;  3KAB A;  1F8A B;  2ZR6 A;  1NMV A;  2ZR5 A;  3KAG A;  1JMQ A;  2ITK A;  2ZQU A;  3M85 A;  2DJY A;  2F21 A;  2XP4 A;  3KAD A;  1O6W A;  3TCZ A;  5AHT A;  2YSB A;  2LAJ A;  2XPB A;  3M7N A;  2ZQV A;  2ZAJ A;  3LE4 A;  4U85 A;  2DK7 A;  2EZ5 W;  2DMV A;  3NTP A;  2XP3 A;  1TK7 A;  2YSF A;  2DWV A;  5CQ2 A;  2M8I A;  3CNG A;  2XP8 A;  2KXQ A;  3TDB A;  3KAH A;  2L4J A;  3KCE A; 
#chains in the Genus database with same CATH topology
 1I5H W;  2ZQS A;  4U84 A;  2M8J A;  3ODK A;  2JXW A;  3KAF A;  5E64 A;  1EG4 A;  5E65 A;  4QIB A;  4REX A;  3KAI A;  2JV4 A;  2MDI A;  2YSI A;  1K9R A;  2RE3 A;  2XP5 A;  1EG3 A;  5U47 A;  4U86 A;  2JX8 A;  3PQH A;  1ZCN A;  2M3O W;  4GLX A;  2YSH A;  3OOB A;  2BA1 A;  2QRV A;  1FLC A;  2XP7 A;  2Q5A A;  2ZQT A;  4A0T A;  1YW5 A;  3MQH A;  3WH0 A;  4A0U A;  3L4H A;  2ZR4 A;  2JMF A;  3FSB A;  2WAE A;  1WMV A;  2YSG A;  4E5R A;  3LKX B;  2XP9 A;  1PIN A;  1K9Q A;  2XPA A;  2XP6 A;  2E45 A;  3MQG A;  2OWO A;  5E62 A;  2DK1 A;  3TC5 A;  1RP5 A;  1WR7 A;  3FS8 A;  3FSC A;  1F8A B;  3KAB A;  2ZR6 A;  1NMV A;  2ZR5 A;  3KAG A;  2Y8N B;  3MCB B;  5E5W A;  1JMQ A;  2ITK A;  2ZQU A;  3M85 A;  2DJY A;  2YAJ B;  2F21 A;  2XP4 A;  3KAD A;  1O6W A;  3TCZ A;  5AHT A;  3LKX A;  2YSB A;  2LAJ A;  2XPB A;  3M7N A;  2ZQV A;  2ZAJ A;  3LE4 A;  4U85 A;  2DK7 A;  2EZ5 W;  2DMV A;  3NTP A;  2XP3 A;  1TK7 A;  2YSF A;  2DWV A;  1TR8 A;  5CQ2 A;  2M8I A;  3CNG A;  3MCB A;  2WAD A;  2XP8 A;  2KXQ A;  3TDB A;  3KAH A;  2L4J A;  3KCE A;  5E66 A; 
#chains in the Genus database with same CATH homology
 1I5H W;  2ZQS A;  4U84 A;  2M8J A;  3ODK A;  2JXW A;  3KAF A;  5E64 A;  1EG4 A;  5E65 A;  4QIB A;  4REX A;  3KAI A;  2JV4 A;  2MDI A;  2YSI A;  1K9R A;  2RE3 A;  2XP5 A;  1EG3 A;  5U47 A;  4U86 A;  2JX8 A;  3PQH A;  1ZCN A;  2M3O W;  4GLX A;  2YSH A;  3OOB A;  2BA1 A;  2QRV A;  1FLC A;  2XP7 A;  2Q5A A;  2ZQT A;  4A0T A;  1YW5 A;  3MQH A;  3WH0 A;  4A0U A;  3L4H A;  2ZR4 A;  2JMF A;  3FSB A;  2WAE A;  1WMV A;  2YSG A;  4E5R A;  3LKX B;  2XP9 A;  1PIN A;  1K9Q A;  2XPA A;  2XP6 A;  2E45 A;  3MQG A;  2OWO A;  5E62 A;  2DK1 A;  3TC5 A;  1RP5 A;  1WR7 A;  3FS8 A;  3FSC A;  1F8A B;  3KAB A;  2ZR6 A;  1NMV A;  2ZR5 A;  3KAG A;  2Y8N B;  3MCB B;  5E5W A;  1JMQ A;  2ITK A;  2ZQU A;  3M85 A;  2DJY A;  2YAJ B;  2F21 A;  2XP4 A;  3KAD A;  1O6W A;  3TCZ A;  5AHT A;  3LKX A;  2YSB A;  2LAJ A;  2XPB A;  3M7N A;  2ZQV A;  2ZAJ A;  3LE4 A;  4U85 A;  2DK7 A;  2EZ5 W;  2DMV A;  3NTP A;  2XP3 A;  1TK7 A;  2YSF A;  2DWV A;  1TR8 A;  5CQ2 A;  2M8I A;  3CNG A;  3MCB A;  2WAD A;  2XP8 A;  2KXQ A;  3TDB A;  3KAH A;  2L4J A;  3KCE A;  5E66 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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