2EZ5 | Genus

Total Genus 5

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	5
sequence length	46
structure length	46
Chain Sequence	GPLGSGEEEPLPPRWSMQVAPNGRTFFIDHASRRTTWIDPRNGRAS

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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

molecule tags	Signalling protein,ligase
source organism	Drosophila melanogaster
publication title	Structural Determinants for High-Affinity Binding in a Nedd4 WW3(*) Domain-Comm PY Motif Complex pubmed doi rcsb
molecule keywords	E3 ubiquitin-protein ligase NEDD4
total genus	5
structure length	46
sequence length	46
ec nomenclature	ec 2.3.2.26: HECT-type E3 ubiquitin transferase.
pdb deposition date	2005-11-10

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
W	PF00397	WW	WW domain

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
2.20.70.10	Mainly Beta	Single Sheet	Ubiquitin Ligase Nedd4; Chain: W;	Ubiquitin Ligase Nedd4; Chain: W;	2ez5W01

2DJYA 1JMQA 1I5HW 2YSHA 2RE3A 2F21A 3KAIA 2XP6A 2XP4A 2ZQTA 4U86A 2YSIA 4U85A 2ZR4A 2ZR6A 3TCZA 1O6WA 2ZQSA 2ZAJA 1EG3A 2XPAA 5AHTA 2M8IA 3TDBA 2EZ5W 2MDIA 3KAGA 3KADA 1TK7A 3KAFA 2JMFA 2ZR5A 1F8AB 1PINA 2JXWA 3KAHA 3L4HA 2DK7A 4U84A 1EG4A 1YW5A 3TC5A 2LAJA 2YSBA 4E5RA 2XP3A 2ZQUA 3WH0A 2YSFA 2YSGA 3ODKA 2JX8A 2XP7A 3OOBA 2DK1A 2Q5AA 3KABA 2DMVA 3NTPA 3M7NA 2L4JA 4QIBA 3CNGA 4REXA 2ITKA 2JV4A 2M8JA 2XPBA 2XP9A 1K9RA 1ZCNA 1K9QA 3KCEA 3M85A 2BA1A 2XP8A 2DWVA 2ZQVA 1WR7A 2E45A 1WMVA 2XP5A 2KXQA 2M3OW 5CQ2A 1NMVA 3LE4A
chains in the Genus database with same CATH superfamily

2DJYA 1JMQA 3PQHA 1I5HW 2YSHA 2RE3A 2F21A 3KAIA 2XP6A 3LKXA 5U47A 5E5WA 3MQGA 2XP4A 2ZQTA 4U86A 2OWOA 2YSIA 2ZR4A 4U85A 2ZR6A 3TCZA 1O6WA 2ZQSA 3FSBA 2ZAJA 1EG3A 2XPAA 5AHTA 2WAEA 2M8IA 3TDBA 3MCBB 5E65A 2EZ5W 2MDIA 3KAGA 1TR8A 3FS8A 3KADA 1TK7A 3KAFA 2JMFA 2ZR5A 1F8AB 1PINA 2JXWA 3KAHA 3L4HA 2DK7A 3MQHA 4U84A 1EG4A 1YW5A 3TC5A 2LAJA 2YSBA 4GLXA 4E5RA 2XP3A 2ZQUA 3WH0A 2YSFA 2YSGA 3ODKA 5E62A 2JX8A 2XP7A 4A0UA 3FSCA 3OOBA 3MCBA 2DK1A 2Q5AA 3KABA 3LKXB 1FLCA 2DMVA 3NTPA 3M7NA 2L4JA 4QIBA 3CNGA 4REXA 2ITKA 2JV4A 2M8JA 2QRVA 2XP9A 2XPBA 5E64A 1ZCNA 1K9RA 1RP5A 1K9QA 3KCEA 3M85A 2BA1A 2XP8A 2DWVA 2Y8NB 2ZQVA 1WR7A 2E45A 1WMVA 2YAJB 5E66A 2XP5A 2WADA 2KXQA 2M3OW 4A0TA 5CQ2A 1NMVA 3LE4A
chains in the Genus database with same CATH topology

#chains in the Genus database with same CATH superfamily
 2DJY A;  1JMQ A;  1I5H W;  2YSH A;  2RE3 A;  2F21 A;  3KAI A;  2XP6 A;  2XP4 A;  2ZQT A;  4U86 A;  2YSI A;  4U85 A;  2ZR4 A;  2ZR6 A;  3TCZ A;  1O6W A;  2ZQS A;  2ZAJ A;  1EG3 A;  2XPA A;  5AHT A;  2M8I A;  3TDB A;  2EZ5 W;  2MDI A;  3KAG A;  3KAD A;  1TK7 A;  3KAF A;  2JMF A;  2ZR5 A;  1F8A B;  1PIN A;  2JXW A;  3KAH A;  3L4H A;  2DK7 A;  4U84 A;  1EG4 A;  1YW5 A;  3TC5 A;  2LAJ A;  2YSB A;  4E5R A;  2XP3 A;  2ZQU A;  3WH0 A;  2YSF A;  2YSG A;  3ODK A;  2JX8 A;  2XP7 A;  3OOB A;  2DK1 A;  2Q5A A;  3KAB A;  2DMV A;  3NTP A;  3M7N A;  2L4J A;  4QIB A;  3CNG A;  4REX A;  2ITK A;  2JV4 A;  2M8J A;  2XPB A;  2XP9 A;  1K9R A;  1ZCN A;  1K9Q A;  3KCE A;  3M85 A;  2BA1 A;  2XP8 A;  2DWV A;  2ZQV A;  1WR7 A;  2E45 A;  1WMV A;  2XP5 A;  2KXQ A;  2M3O W;  5CQ2 A;  1NMV A;  3LE4 A; 
#chains in the Genus database with same CATH topology
 2DJY A;  1JMQ A;  3PQH A;  1I5H W;  2YSH A;  2RE3 A;  2F21 A;  3KAI A;  2XP6 A;  3LKX A;  5U47 A;  5E5W A;  3MQG A;  2XP4 A;  2ZQT A;  4U86 A;  2OWO A;  2YSI A;  2ZR4 A;  4U85 A;  2ZR6 A;  3TCZ A;  1O6W A;  2ZQS A;  3FSB A;  2ZAJ A;  1EG3 A;  2XPA A;  5AHT A;  2WAE A;  2M8I A;  3TDB A;  3MCB B;  5E65 A;  2EZ5 W;  2MDI A;  3KAG A;  1TR8 A;  3FS8 A;  3KAD A;  1TK7 A;  3KAF A;  2JMF A;  2ZR5 A;  1F8A B;  1PIN A;  2JXW A;  3KAH A;  3L4H A;  2DK7 A;  3MQH A;  4U84 A;  1EG4 A;  1YW5 A;  3TC5 A;  2LAJ A;  2YSB A;  4GLX A;  4E5R A;  2XP3 A;  2ZQU A;  3WH0 A;  2YSF A;  2YSG A;  3ODK A;  5E62 A;  2JX8 A;  2XP7 A;  4A0U A;  3FSC A;  3OOB A;  3MCB A;  2DK1 A;  2Q5A A;  3KAB A;  3LKX B;  1FLC A;  2DMV A;  3NTP A;  3M7N A;  2L4J A;  4QIB A;  3CNG A;  4REX A;  2ITK A;  2JV4 A;  2M8J A;  2QRV A;  2XP9 A;  2XPB A;  5E64 A;  1ZCN A;  1K9R A;  1RP5 A;  1K9Q A;  3KCE A;  3M85 A;  2BA1 A;  2XP8 A;  2DWV A;  2Y8N B;  2ZQV A;  1WR7 A;  2E45 A;  1WMV A;  2YAJ B;  5E66 A;  2XP5 A;  2WAD A;  2KXQ A;  2M3O W;  4A0T A;  5CQ2 A;  1NMV A;  3LE4 A; 
#chains in the Genus database with same CATH homology
 2DJY A;  1JMQ A;  3PQH A;  1I5H W;  2YSH A;  2RE3 A;  2F21 A;  3KAI A;  2XP6 A;  3LKX A;  5U47 A;  5E5W A;  3MQG A;  2XP4 A;  2ZQT A;  4U86 A;  2OWO A;  2YSI A;  2ZR4 A;  4U85 A;  2ZR6 A;  3TCZ A;  1O6W A;  2ZQS A;  3FSB A;  2ZAJ A;  1EG3 A;  2XPA A;  5AHT A;  2WAE A;  2M8I A;  3TDB A;  3MCB B;  5E65 A;  2EZ5 W;  2MDI A;  3KAG A;  1TR8 A;  3FS8 A;  3KAD A;  1TK7 A;  3KAF A;  2JMF A;  2ZR5 A;  1F8A B;  1PIN A;  2JXW A;  3KAH A;  3L4H A;  2DK7 A;  3MQH A;  4U84 A;  1EG4 A;  1YW5 A;  3TC5 A;  2LAJ A;  2YSB A;  4GLX A;  4E5R A;  2XP3 A;  2ZQU A;  3WH0 A;  2YSF A;  2YSG A;  3ODK A;  5E62 A;  2JX8 A;  2XP7 A;  4A0U A;  3FSC A;  3OOB A;  3MCB A;  2DK1 A;  2Q5A A;  3KAB A;  3LKX B;  1FLC A;  2DMV A;  3NTP A;  3M7N A;  2L4J A;  4QIB A;  3CNG A;  4REX A;  2ITK A;  2JV4 A;  2M8J A;  2QRV A;  2XP9 A;  2XPB A;  5E64 A;  1ZCN A;  1K9R A;  1RP5 A;  1K9Q A;  3KCE A;  3M85 A;  2BA1 A;  2XP8 A;  2DWV A;  2Y8N B;  2ZQV A;  1WR7 A;  2E45 A;  1WMV A;  2YAJ B;  5E66 A;  2XP5 A;  2WAD A;  2KXQ A;  2M3O W;  4A0T A;  5CQ2 A;  1NMV A;  3LE4 A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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2EZ5W

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

pfam database annotations