2KXQA

Solution structure of smurf2 ww2 and ww3 bound to smad7 py motif containing peptide
Total Genus 9
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
9
sequence length
90
structure length
90
Chain Sequence
GPLGGSPPDLPEGYEQRTTQQGQVYFLHTQTGVSTWHDPRVPRDLSNINCEELGPLPPGWEIRNTATGRVYFVDHNNRTTQFTDPRLSAN
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Protein binding
source organism Homo sapiens
publication title Coupling of tandem Smad ubiquitination regulatory factor (Smurf) WW domains modulates target specificity.
pubmed doi rcsb
molecule keywords E3 ubiquitin-protein ligase SMURF2
total genus 9
structure length 90
sequence length 90
ec nomenclature ec 2.3.2.26: HECT-type E3 ubiquitin transferase.
pdb deposition date 2010-05-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00397 WW WW domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.20.70.10 Mainly Beta Single Sheet Ubiquitin Ligase Nedd4; Chain: W; Ubiquitin Ligase Nedd4; Chain: W; 2kxqA01
2.20.70.10 Mainly Beta Single Sheet Ubiquitin Ligase Nedd4; Chain: W; Ubiquitin Ligase Nedd4; Chain: W; 2kxqA02
4U86A 3OOBA 2ZQTA 3KADA 1ZCNA 3TDBA 5CQ2A 2BA1A 2XP9A 2YSGA 2F21A 2JX8A 2ZAJA 3KABA 3KAGA 2DK1A 1K9QA 2YSIA 2DK7A 1TK7A 2E45A 2ZQUA 2RE3A 1YW5A 1K9RA 2YSHA 3TCZA 2MDIA 4REXA 2XPAA 5AHTA 3ODKA 3WH0A 3KAHA 2M8JA 2ZR5A 3KCEA 1EG4A 2XP8A 2XP6A 2M3OW 3TC5A 2ZQSA 1WMVA 1I5HW 2ZR6A 2XP4A 2LAJA 2M8IA 4QIBA 4U84A 2ZQVA 3LE4A 3NTPA 2DWVA 2JXWA 4U85A 3CNGA 3M7NA 2ZR4A 3L4HA 2Q5AA 2EZ5W 2ITKA 2XPBA 3KAFA 1O6WA 3KAIA 2KXQA 2JMFA 1PINA 4E5RA 1EG3A 2YSBA 2XP3A 1WR7A 1JMQA 2YSFA 2L4JA 2XP5A 1NMVA 2DJYA 2XP7A 2JV4A 2DMVA 3M85A 1F8AB
chains in the Genus database with same CATH superfamily
4U86A 3OOBA 2ZQTA 5E64A 3KADA 1ZCNA 1TR8A 3TDBA 5CQ2A 2BA1A 2XP9A 2YSGA 2F21A 2QRVA 3PQHA 2JX8A 2ZAJA 3KABA 3KAGA 3MCBA 2DK1A 1K9QA 2YSIA 2DK7A 1TK7A 4A0TA 2E45A 2ZQUA 4A0UA 2RE3A 1YW5A 3MCBB 3MQGA 1K9RA 2YSHA 3TCZA 3FSBA 2MDIA 4REXA 5U47A 2YAJB 4GLXA 2XPAA 3FS8A 5AHTA 3ODKA 3WH0A 2OWOA 2WADA 3KAHA 2M8JA 2ZR5A 3KCEA 1EG4A 3LKXA 2XP8A 2XP6A 2M3OW 1FLCA 5E66A 3TC5A 2Y8NB 5E65A 5E5WA 2ZQSA 1WMVA 1I5HW 2ZR6A 2XP4A 2LAJA 2M8IA 4QIBA 4U84A 2ZQVA 3LKXB 3LE4A 2WAEA 3MQHA 3NTPA 2DWVA 2JXWA 4U85A 3CNGA 3M7NA 2ZR4A 3L4HA 2Q5AA 2EZ5W 2ITKA 2XPBA 3KAFA 1O6WA 3KAIA 2KXQA 2JMFA 1PINA 4E5RA 1EG3A 2YSBA 3FSCA 5E62A 2XP3A 1WR7A 1JMQA 2YSFA 2L4JA 2XP5A 1NMVA 2DJYA 2XP7A 2JV4A 1RP5A 2DMVA 3M85A 1F8AB
chains in the Genus database with same CATH topology
4U86A 3OOBA 2ZQTA 5E64A 3KADA 1ZCNA 1TR8A 3TDBA 5CQ2A 2BA1A 2XP9A 2YSGA 2F21A 2QRVA 3PQHA 2JX8A 2ZAJA 3KABA 3KAGA 3MCBA 2DK1A 1K9QA 2YSIA 2DK7A 1TK7A 4A0TA 2E45A 2ZQUA 4A0UA 2RE3A 1YW5A 3MCBB 3MQGA 1K9RA 2YSHA 3TCZA 3FSBA 2MDIA 4REXA 5U47A 2YAJB 4GLXA 2XPAA 3FS8A 5AHTA 3ODKA 3WH0A 2OWOA 2WADA 3KAHA 2M8JA 2ZR5A 3KCEA 1EG4A 3LKXA 2XP8A 2XP6A 2M3OW 1FLCA 5E66A 3TC5A 2Y8NB 5E65A 5E5WA 2ZQSA 1WMVA 1I5HW 2ZR6A 2XP4A 2LAJA 2M8IA 4QIBA 4U84A 2ZQVA 3LKXB 3LE4A 2WAEA 3MQHA 3NTPA 2DWVA 2JXWA 4U85A 3CNGA 3M7NA 2ZR4A 3L4HA 2Q5AA 2EZ5W 2ITKA 2XPBA 3KAFA 1O6WA 3KAIA 2KXQA 2JMFA 1PINA 4E5RA 1EG3A 2YSBA 3FSCA 5E62A 2XP3A 1WR7A 1JMQA 2YSFA 2L4JA 2XP5A 1NMVA 2DJYA 2XP7A 2JV4A 1RP5A 2DMVA 3M85A 1F8AB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4U86 A;  3OOB A;  2ZQT A;  3KAD A;  1ZCN A;  3TDB A;  5CQ2 A;  2BA1 A;  2XP9 A;  2YSG A;  2F21 A;  2JX8 A;  2ZAJ A;  3KAB A;  3KAG A;  2DK1 A;  1K9Q A;  2YSI A;  2DK7 A;  1TK7 A;  2E45 A;  2ZQU A;  2RE3 A;  1YW5 A;  1K9R A;  2YSH A;  3TCZ A;  2MDI A;  4REX A;  2XPA A;  5AHT A;  3ODK A;  3WH0 A;  3KAH A;  2M8J A;  2ZR5 A;  3KCE A;  1EG4 A;  2XP8 A;  2XP6 A;  2M3O W;  3TC5 A;  2ZQS A;  1WMV A;  1I5H W;  2ZR6 A;  2XP4 A;  2LAJ A;  2M8I A;  4QIB A;  4U84 A;  2ZQV A;  3LE4 A;  3NTP A;  2DWV A;  2JXW A;  4U85 A;  3CNG A;  3M7N A;  2ZR4 A;  3L4H A;  2Q5A A;  2EZ5 W;  2ITK A;  2XPB A;  3KAF A;  1O6W A;  3KAI A;  2KXQ A;  2JMF A;  1PIN A;  4E5R A;  1EG3 A;  2YSB A;  2XP3 A;  1WR7 A;  1JMQ A;  2YSF A;  2L4J A;  2XP5 A;  1NMV A;  2DJY A;  2XP7 A;  2JV4 A;  2DMV A;  3M85 A;  1F8A B; 
#chains in the Genus database with same CATH topology
 4U86 A;  3OOB A;  2ZQT A;  5E64 A;  3KAD A;  1ZCN A;  1TR8 A;  3TDB A;  5CQ2 A;  2BA1 A;  2XP9 A;  2YSG A;  2F21 A;  2QRV A;  3PQH A;  2JX8 A;  2ZAJ A;  3KAB A;  3KAG A;  3MCB A;  2DK1 A;  1K9Q A;  2YSI A;  2DK7 A;  1TK7 A;  4A0T A;  2E45 A;  2ZQU A;  4A0U A;  2RE3 A;  1YW5 A;  3MCB B;  3MQG A;  1K9R A;  2YSH A;  3TCZ A;  3FSB A;  2MDI A;  4REX A;  5U47 A;  2YAJ B;  4GLX A;  2XPA A;  3FS8 A;  5AHT A;  3ODK A;  3WH0 A;  2OWO A;  2WAD A;  3KAH A;  2M8J A;  2ZR5 A;  3KCE A;  1EG4 A;  3LKX A;  2XP8 A;  2XP6 A;  2M3O W;  1FLC A;  5E66 A;  3TC5 A;  2Y8N B;  5E65 A;  5E5W A;  2ZQS A;  1WMV A;  1I5H W;  2ZR6 A;  2XP4 A;  2LAJ A;  2M8I A;  4QIB A;  4U84 A;  2ZQV A;  3LKX B;  3LE4 A;  2WAE A;  3MQH A;  3NTP A;  2DWV A;  2JXW A;  4U85 A;  3CNG A;  3M7N A;  2ZR4 A;  3L4H A;  2Q5A A;  2EZ5 W;  2ITK A;  2XPB A;  3KAF A;  1O6W A;  3KAI A;  2KXQ A;  2JMF A;  1PIN A;  4E5R A;  1EG3 A;  2YSB A;  3FSC A;  5E62 A;  2XP3 A;  1WR7 A;  1JMQ A;  2YSF A;  2L4J A;  2XP5 A;  1NMV A;  2DJY A;  2XP7 A;  2JV4 A;  1RP5 A;  2DMV A;  3M85 A;  1F8A B; 
#chains in the Genus database with same CATH homology
 4U86 A;  3OOB A;  2ZQT A;  5E64 A;  3KAD A;  1ZCN A;  1TR8 A;  3TDB A;  5CQ2 A;  2BA1 A;  2XP9 A;  2YSG A;  2F21 A;  2QRV A;  3PQH A;  2JX8 A;  2ZAJ A;  3KAB A;  3KAG A;  3MCB A;  2DK1 A;  1K9Q A;  2YSI A;  2DK7 A;  1TK7 A;  4A0T A;  2E45 A;  2ZQU A;  4A0U A;  2RE3 A;  1YW5 A;  3MCB B;  3MQG A;  1K9R A;  2YSH A;  3TCZ A;  3FSB A;  2MDI A;  4REX A;  5U47 A;  2YAJ B;  4GLX A;  2XPA A;  3FS8 A;  5AHT A;  3ODK A;  3WH0 A;  2OWO A;  2WAD A;  3KAH A;  2M8J A;  2ZR5 A;  3KCE A;  1EG4 A;  3LKX A;  2XP8 A;  2XP6 A;  2M3O W;  1FLC A;  5E66 A;  3TC5 A;  2Y8N B;  5E65 A;  5E5W A;  2ZQS A;  1WMV A;  1I5H W;  2ZR6 A;  2XP4 A;  2LAJ A;  2M8I A;  4QIB A;  4U84 A;  2ZQV A;  3LKX B;  3LE4 A;  2WAE A;  3MQH A;  3NTP A;  2DWV A;  2JXW A;  4U85 A;  3CNG A;  3M7N A;  2ZR4 A;  3L4H A;  2Q5A A;  2EZ5 W;  2ITK A;  2XPB A;  3KAF A;  1O6W A;  3KAI A;  2KXQ A;  2JMF A;  1PIN A;  4E5R A;  1EG3 A;  2YSB A;  3FSC A;  5E62 A;  2XP3 A;  1WR7 A;  1JMQ A;  2YSF A;  2L4J A;  2XP5 A;  1NMV A;  2DJY A;  2XP7 A;  2JV4 A;  1RP5 A;  2DMV A;  3M85 A;  1F8A B; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...