2M8IA

Structure of pin1 ww domain
Total Genus 3
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
3
sequence length
43
structure length
43
Chain Sequence
GLEHMADEEKLPPGWEKRMSRSSGRVYYFNHITNASQWERPSG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Molecular crowding drives active Pin1 into nonspecific complexes with endogenous proteins prior to substrate recognition.
pubmed doi rcsb
molecule tags Isomerase
source organism Homo sapiens
molecule keywords Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
total genus 3
structure length 43
sequence length 43
ec nomenclature ec 5.2.1.8: Peptidylprolyl isomerase.
pdb deposition date 2013-05-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00397 WW WW domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.20.70.10 Mainly Beta Single Sheet Ubiquitin Ligase Nedd4; Chain: W; Ubiquitin Ligase Nedd4; Chain: W; 2m8iA01
2YSFA 1YW5A 2DJYA 4QIBA 3NTPA 2YSHA 2JMFA 1K9QA 2KXQA 2YSIA 3TC5A 1F8AB 3WH0A 2XP6A 2XP8A 5CQ2A 2F21A 2ZQTA 2JXWA 3KAIA 2Q5AA 3KAHA 3KADA 2ZQUA 1ZCNA 2XP5A 1EG4A 2ITKA 2XP7A 4U84A 3CNGA 1TK7A 3OOBA 3M7NA 2YSBA 3KAGA 2ZR5A 2ZQSA 2M3OW 2M8JA 2ZR4A 2ZQVA 2M8IA 2XPAA 2RE3A 3L4HA 2BA1A 2JV4A 2LAJA 1WMVA 2YSGA 4E5RA 2E45A 2DK1A 2DK7A 1I5HW 1K9RA 2JX8A 2XPBA 3KABA 2XP4A 1JMQA 5AHTA 1WR7A 2XP9A 3KAFA 2EZ5W 1PINA 1EG3A 4REXA 3TCZA 2DMVA 2MDIA 2L4JA 3ODKA 2XP3A 2ZR6A 2DWVA 2ZAJA 3TDBA 3M85A 1O6WA 1NMVA 3LE4A 4U85A 3KCEA 4U86A
chains in the Genus database with same CATH superfamily
2OWOA 1TR8A 2YSFA 1YW5A 2DJYA 4A0UA 4QIBA 3NTPA 2YSHA 5E66A 2JMFA 3FS8A 1K9QA 2KXQA 2YSIA 3TC5A 1F8AB 3WH0A 2XP6A 2XP8A 5CQ2A 2F21A 2ZQTA 2JXWA 2WADA 1RP5A 3KAIA 2Q5AA 3KAHA 3KADA 3FSCA 2ZQUA 1FLCA 1ZCNA 2XP5A 1EG4A 2WAEA 2ITKA 2XP7A 4U84A 3CNGA 3MCBA 1TK7A 3OOBA 3M7NA 2YSBA 3KAGA 2ZR5A 2ZQSA 2M3OW 2M8JA 2ZR4A 2ZQVA 2YAJB 2M8IA 2XPAA 2RE3A 3L4HA 2BA1A 2JV4A 2LAJA 1WMVA 2YSGA 3FSBA 4E5RA 2E45A 5E64A 2Y8NB 5E62A 2DK1A 3PQHA 2DK7A 5E65A 1I5HW 1K9RA 3LKXA 2JX8A 2XPBA 3KABA 2XP4A 1JMQA 5AHTA 1WR7A 2XP9A 3KAFA 2EZ5W 4GLXA 1PINA 1EG3A 4REXA 3TCZA 2DMVA 5E5WA 3MQHA 4A0TA 2QRVA 2MDIA 2L4JA 3MQGA 3ODKA 2XP3A 2ZR6A 2DWVA 3LKXB 3MCBB 2ZAJA 3TDBA 3M85A 1O6WA 1NMVA 5U47A 3LE4A 4U85A 3KCEA 4U86A
chains in the Genus database with same CATH topology
2OWOA 1TR8A 2YSFA 1YW5A 2DJYA 4A0UA 4QIBA 3NTPA 2YSHA 5E66A 2JMFA 3FS8A 1K9QA 2KXQA 2YSIA 3TC5A 1F8AB 3WH0A 2XP6A 2XP8A 5CQ2A 2F21A 2ZQTA 2JXWA 2WADA 1RP5A 3KAIA 2Q5AA 3KAHA 3KADA 3FSCA 2ZQUA 1FLCA 1ZCNA 2XP5A 1EG4A 2WAEA 2ITKA 2XP7A 4U84A 3CNGA 3MCBA 1TK7A 3OOBA 3M7NA 2YSBA 3KAGA 2ZR5A 2ZQSA 2M3OW 2M8JA 2ZR4A 2ZQVA 2YAJB 2M8IA 2XPAA 2RE3A 3L4HA 2BA1A 2JV4A 2LAJA 1WMVA 2YSGA 3FSBA 4E5RA 2E45A 5E64A 2Y8NB 5E62A 2DK1A 3PQHA 2DK7A 5E65A 1I5HW 1K9RA 3LKXA 2JX8A 2XPBA 3KABA 2XP4A 1JMQA 5AHTA 1WR7A 2XP9A 3KAFA 2EZ5W 4GLXA 1PINA 1EG3A 4REXA 3TCZA 2DMVA 5E5WA 3MQHA 4A0TA 2QRVA 2MDIA 2L4JA 3MQGA 3ODKA 2XP3A 2ZR6A 2DWVA 3LKXB 3MCBB 2ZAJA 3TDBA 3M85A 1O6WA 1NMVA 5U47A 3LE4A 4U85A 3KCEA 4U86A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2YSF A;  1YW5 A;  2DJY A;  4QIB A;  3NTP A;  2YSH A;  2JMF A;  1K9Q A;  2KXQ A;  2YSI A;  3TC5 A;  1F8A B;  3WH0 A;  2XP6 A;  2XP8 A;  5CQ2 A;  2F21 A;  2ZQT A;  2JXW A;  3KAI A;  2Q5A A;  3KAH A;  3KAD A;  2ZQU A;  1ZCN A;  2XP5 A;  1EG4 A;  2ITK A;  2XP7 A;  4U84 A;  3CNG A;  1TK7 A;  3OOB A;  3M7N A;  2YSB A;  3KAG A;  2ZR5 A;  2ZQS A;  2M3O W;  2M8J A;  2ZR4 A;  2ZQV A;  2M8I A;  2XPA A;  2RE3 A;  3L4H A;  2BA1 A;  2JV4 A;  2LAJ A;  1WMV A;  2YSG A;  4E5R A;  2E45 A;  2DK1 A;  2DK7 A;  1I5H W;  1K9R A;  2JX8 A;  2XPB A;  3KAB A;  2XP4 A;  1JMQ A;  5AHT A;  1WR7 A;  2XP9 A;  3KAF A;  2EZ5 W;  1PIN A;  1EG3 A;  4REX A;  3TCZ A;  2DMV A;  2MDI A;  2L4J A;  3ODK A;  2XP3 A;  2ZR6 A;  2DWV A;  2ZAJ A;  3TDB A;  3M85 A;  1O6W A;  1NMV A;  3LE4 A;  4U85 A;  3KCE A;  4U86 A; 
#chains in the Genus database with same CATH topology
 2OWO A;  1TR8 A;  2YSF A;  1YW5 A;  2DJY A;  4A0U A;  4QIB A;  3NTP A;  2YSH A;  5E66 A;  2JMF A;  3FS8 A;  1K9Q A;  2KXQ A;  2YSI A;  3TC5 A;  1F8A B;  3WH0 A;  2XP6 A;  2XP8 A;  5CQ2 A;  2F21 A;  2ZQT A;  2JXW A;  2WAD A;  1RP5 A;  3KAI A;  2Q5A A;  3KAH A;  3KAD A;  3FSC A;  2ZQU A;  1FLC A;  1ZCN A;  2XP5 A;  1EG4 A;  2WAE A;  2ITK A;  2XP7 A;  4U84 A;  3CNG A;  3MCB A;  1TK7 A;  3OOB A;  3M7N A;  2YSB A;  3KAG A;  2ZR5 A;  2ZQS A;  2M3O W;  2M8J A;  2ZR4 A;  2ZQV A;  2YAJ B;  2M8I A;  2XPA A;  2RE3 A;  3L4H A;  2BA1 A;  2JV4 A;  2LAJ A;  1WMV A;  2YSG A;  3FSB A;  4E5R A;  2E45 A;  5E64 A;  2Y8N B;  5E62 A;  2DK1 A;  3PQH A;  2DK7 A;  5E65 A;  1I5H W;  1K9R A;  3LKX A;  2JX8 A;  2XPB A;  3KAB A;  2XP4 A;  1JMQ A;  5AHT A;  1WR7 A;  2XP9 A;  3KAF A;  2EZ5 W;  4GLX A;  1PIN A;  1EG3 A;  4REX A;  3TCZ A;  2DMV A;  5E5W A;  3MQH A;  4A0T A;  2QRV A;  2MDI A;  2L4J A;  3MQG A;  3ODK A;  2XP3 A;  2ZR6 A;  2DWV A;  3LKX B;  3MCB B;  2ZAJ A;  3TDB A;  3M85 A;  1O6W A;  1NMV A;  5U47 A;  3LE4 A;  4U85 A;  3KCE A;  4U86 A; 
#chains in the Genus database with same CATH homology
 2OWO A;  1TR8 A;  2YSF A;  1YW5 A;  2DJY A;  4A0U A;  4QIB A;  3NTP A;  2YSH A;  5E66 A;  2JMF A;  3FS8 A;  1K9Q A;  2KXQ A;  2YSI A;  3TC5 A;  1F8A B;  3WH0 A;  2XP6 A;  2XP8 A;  5CQ2 A;  2F21 A;  2ZQT A;  2JXW A;  2WAD A;  1RP5 A;  3KAI A;  2Q5A A;  3KAH A;  3KAD A;  3FSC A;  2ZQU A;  1FLC A;  1ZCN A;  2XP5 A;  1EG4 A;  2WAE A;  2ITK A;  2XP7 A;  4U84 A;  3CNG A;  3MCB A;  1TK7 A;  3OOB A;  3M7N A;  2YSB A;  3KAG A;  2ZR5 A;  2ZQS A;  2M3O W;  2M8J A;  2ZR4 A;  2ZQV A;  2YAJ B;  2M8I A;  2XPA A;  2RE3 A;  3L4H A;  2BA1 A;  2JV4 A;  2LAJ A;  1WMV A;  2YSG A;  3FSB A;  4E5R A;  2E45 A;  5E64 A;  2Y8N B;  5E62 A;  2DK1 A;  3PQH A;  2DK7 A;  5E65 A;  1I5H W;  1K9R A;  3LKX A;  2JX8 A;  2XPB A;  3KAB A;  2XP4 A;  1JMQ A;  5AHT A;  1WR7 A;  2XP9 A;  3KAF A;  2EZ5 W;  4GLX A;  1PIN A;  1EG3 A;  4REX A;  3TCZ A;  2DMV A;  5E5W A;  3MQH A;  4A0T A;  2QRV A;  2MDI A;  2L4J A;  3MQG A;  3ODK A;  2XP3 A;  2ZR6 A;  2DWV A;  3LKX B;  3MCB B;  2ZAJ A;  3TDB A;  3M85 A;  1O6W A;  1NMV A;  5U47 A;  3LE4 A;  4U85 A;  3KCE A;  4U86 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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