2M8JA

Structure of pin1 ww domain phospho-mimic s16e
Total Genus 3
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
3
sequence length
43
structure length
43
Chain Sequence
GLEHMADEEKLPPGWEKRMERSSGRVYYFNHITNASQWERPSG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Molecular crowding drives active Pin1 into nonspecific complexes with endogenous proteins prior to substrate recognition.
pubmed doi rcsb
molecule tags Isomerase
source organism Homo sapiens
molecule keywords Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
total genus 3
structure length 43
sequence length 43
ec nomenclature ec 5.2.1.8: Peptidylprolyl isomerase.
pdb deposition date 2013-05-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00397 WW WW domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.20.70.10 Mainly Beta Single Sheet Ubiquitin Ligase Nedd4; Chain: W; Ubiquitin Ligase Nedd4; Chain: W; 2m8jA01
1WMVA 2JV4A 1F8AB 3M85A 2ZR4A 2YSFA 2YSHA 2YSIA 1ZCNA 2XP6A 1TK7A 2DWVA 3KCEA 2M8IA 2ZQTA 2E45A 2ZR5A 3TDBA 1O6WA 2XPBA 3M7NA 2RE3A 1NMVA 2XP3A 5CQ2A 2XPAA 1K9QA 3OOBA 3KADA 2ITKA 2XP7A 3KAFA 3TCZA 2ZR6A 4U86A 4U85A 1I5HW 1YW5A 2ZQUA 1JMQA 3KAIA 2BA1A 2MDIA 3WH0A 3NTPA 2Q5AA 3KABA 3KAHA 2XP5A 2EZ5W 2DMVA 2JMFA 2XP9A 1K9RA 2ZQVA 2DK7A 2L4JA 2YSBA 2KXQA 4QIBA 3LE4A 2XP4A 2JXWA 2M8JA 1EG4A 3L4HA 4U84A 3ODKA 2DJYA 2XP8A 1WR7A 4E5RA 2LAJA 2M3OW 4REXA 3TC5A 5AHTA 2YSGA 3KAGA 2JX8A 2ZAJA 1PINA 1EG3A 2F21A 3CNGA 2ZQSA 2DK1A
chains in the Genus database with same CATH superfamily
1WMVA 2JV4A 1RP5A 1F8AB 3M85A 2ZR4A 2YSFA 3LKXB 2YSHA 2YSIA 1ZCNA 2XP6A 3LKXA 1TK7A 2WADA 2DWVA 1FLCA 3KCEA 2M8IA 2ZQTA 2E45A 2WAEA 2ZR5A 3TDBA 5E66A 1O6WA 2XPBA 3FS8A 3MCBA 3M7NA 2RE3A 1NMVA 2XP3A 5CQ2A 2XPAA 1K9QA 5E64A 3OOBA 3KADA 2ITKA 2XP7A 2QRVA 4A0UA 3KAFA 3TCZA 4GLXA 5U47A 2OWOA 2ZR6A 5E65A 4U86A 4U85A 3MCBB 1I5HW 1YW5A 3MQHA 2ZQUA 1JMQA 3KAIA 2BA1A 2MDIA 3WH0A 3NTPA 2Q5AA 3KABA 3KAHA 4A0TA 5E5WA 2XP5A 2EZ5W 2DMVA 2YAJB 2JMFA 2XP9A 1K9RA 2ZQVA 5E62A 2DK7A 2L4JA 2YSBA 2KXQA 3PQHA 1TR8A 4QIBA 3LE4A 2XP4A 2JXWA 2Y8NB 2M8JA 1EG4A 3L4HA 3FSCA 4U84A 3ODKA 2DJYA 3MQGA 2XP8A 1WR7A 4E5RA 2LAJA 2M3OW 4REXA 3TC5A 3FSBA 5AHTA 2YSGA 3KAGA 2JX8A 2ZAJA 1PINA 1EG3A 2F21A 3CNGA 2ZQSA 2DK1A
chains in the Genus database with same CATH topology
1WMVA 2JV4A 1RP5A 1F8AB 3M85A 2ZR4A 2YSFA 3LKXB 2YSHA 2YSIA 1ZCNA 2XP6A 3LKXA 1TK7A 2WADA 2DWVA 1FLCA 3KCEA 2M8IA 2ZQTA 2E45A 2WAEA 2ZR5A 3TDBA 5E66A 1O6WA 2XPBA 3FS8A 3MCBA 3M7NA 2RE3A 1NMVA 2XP3A 5CQ2A 2XPAA 1K9QA 5E64A 3OOBA 3KADA 2ITKA 2XP7A 2QRVA 4A0UA 3KAFA 3TCZA 4GLXA 5U47A 2OWOA 2ZR6A 5E65A 4U86A 4U85A 3MCBB 1I5HW 1YW5A 3MQHA 2ZQUA 1JMQA 3KAIA 2BA1A 2MDIA 3WH0A 3NTPA 2Q5AA 3KABA 3KAHA 4A0TA 5E5WA 2XP5A 2EZ5W 2DMVA 2YAJB 2JMFA 2XP9A 1K9RA 2ZQVA 5E62A 2DK7A 2L4JA 2YSBA 2KXQA 3PQHA 1TR8A 4QIBA 3LE4A 2XP4A 2JXWA 2Y8NB 2M8JA 1EG4A 3L4HA 3FSCA 4U84A 3ODKA 2DJYA 3MQGA 2XP8A 1WR7A 4E5RA 2LAJA 2M3OW 4REXA 3TC5A 3FSBA 5AHTA 2YSGA 3KAGA 2JX8A 2ZAJA 1PINA 1EG3A 2F21A 3CNGA 2ZQSA 2DK1A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1WMV A;  2JV4 A;  1F8A B;  3M85 A;  2ZR4 A;  2YSF A;  2YSH A;  2YSI A;  1ZCN A;  2XP6 A;  1TK7 A;  2DWV A;  3KCE A;  2M8I A;  2ZQT A;  2E45 A;  2ZR5 A;  3TDB A;  1O6W A;  2XPB A;  3M7N A;  2RE3 A;  1NMV A;  2XP3 A;  5CQ2 A;  2XPA A;  1K9Q A;  3OOB A;  3KAD A;  2ITK A;  2XP7 A;  3KAF A;  3TCZ A;  2ZR6 A;  4U86 A;  4U85 A;  1I5H W;  1YW5 A;  2ZQU A;  1JMQ A;  3KAI A;  2BA1 A;  2MDI A;  3WH0 A;  3NTP A;  2Q5A A;  3KAB A;  3KAH A;  2XP5 A;  2EZ5 W;  2DMV A;  2JMF A;  2XP9 A;  1K9R A;  2ZQV A;  2DK7 A;  2L4J A;  2YSB A;  2KXQ A;  4QIB A;  3LE4 A;  2XP4 A;  2JXW A;  2M8J A;  1EG4 A;  3L4H A;  4U84 A;  3ODK A;  2DJY A;  2XP8 A;  1WR7 A;  4E5R A;  2LAJ A;  2M3O W;  4REX A;  3TC5 A;  5AHT A;  2YSG A;  3KAG A;  2JX8 A;  2ZAJ A;  1PIN A;  1EG3 A;  2F21 A;  3CNG A;  2ZQS A;  2DK1 A; 
#chains in the Genus database with same CATH topology
 1WMV A;  2JV4 A;  1RP5 A;  1F8A B;  3M85 A;  2ZR4 A;  2YSF A;  3LKX B;  2YSH A;  2YSI A;  1ZCN A;  2XP6 A;  3LKX A;  1TK7 A;  2WAD A;  2DWV A;  1FLC A;  3KCE A;  2M8I A;  2ZQT A;  2E45 A;  2WAE A;  2ZR5 A;  3TDB A;  5E66 A;  1O6W A;  2XPB A;  3FS8 A;  3MCB A;  3M7N A;  2RE3 A;  1NMV A;  2XP3 A;  5CQ2 A;  2XPA A;  1K9Q A;  5E64 A;  3OOB A;  3KAD A;  2ITK A;  2XP7 A;  2QRV A;  4A0U A;  3KAF A;  3TCZ A;  4GLX A;  5U47 A;  2OWO A;  2ZR6 A;  5E65 A;  4U86 A;  4U85 A;  3MCB B;  1I5H W;  1YW5 A;  3MQH A;  2ZQU A;  1JMQ A;  3KAI A;  2BA1 A;  2MDI A;  3WH0 A;  3NTP A;  2Q5A A;  3KAB A;  3KAH A;  4A0T A;  5E5W A;  2XP5 A;  2EZ5 W;  2DMV A;  2YAJ B;  2JMF A;  2XP9 A;  1K9R A;  2ZQV A;  5E62 A;  2DK7 A;  2L4J A;  2YSB A;  2KXQ A;  3PQH A;  1TR8 A;  4QIB A;  3LE4 A;  2XP4 A;  2JXW A;  2Y8N B;  2M8J A;  1EG4 A;  3L4H A;  3FSC A;  4U84 A;  3ODK A;  2DJY A;  3MQG A;  2XP8 A;  1WR7 A;  4E5R A;  2LAJ A;  2M3O W;  4REX A;  3TC5 A;  3FSB A;  5AHT A;  2YSG A;  3KAG A;  2JX8 A;  2ZAJ A;  1PIN A;  1EG3 A;  2F21 A;  3CNG A;  2ZQS A;  2DK1 A; 
#chains in the Genus database with same CATH homology
 1WMV A;  2JV4 A;  1RP5 A;  1F8A B;  3M85 A;  2ZR4 A;  2YSF A;  3LKX B;  2YSH A;  2YSI A;  1ZCN A;  2XP6 A;  3LKX A;  1TK7 A;  2WAD A;  2DWV A;  1FLC A;  3KCE A;  2M8I A;  2ZQT A;  2E45 A;  2WAE A;  2ZR5 A;  3TDB A;  5E66 A;  1O6W A;  2XPB A;  3FS8 A;  3MCB A;  3M7N A;  2RE3 A;  1NMV A;  2XP3 A;  5CQ2 A;  2XPA A;  1K9Q A;  5E64 A;  3OOB A;  3KAD A;  2ITK A;  2XP7 A;  2QRV A;  4A0U A;  3KAF A;  3TCZ A;  4GLX A;  5U47 A;  2OWO A;  2ZR6 A;  5E65 A;  4U86 A;  4U85 A;  3MCB B;  1I5H W;  1YW5 A;  3MQH A;  2ZQU A;  1JMQ A;  3KAI A;  2BA1 A;  2MDI A;  3WH0 A;  3NTP A;  2Q5A A;  3KAB A;  3KAH A;  4A0T A;  5E5W A;  2XP5 A;  2EZ5 W;  2DMV A;  2YAJ B;  2JMF A;  2XP9 A;  1K9R A;  2ZQV A;  5E62 A;  2DK7 A;  2L4J A;  2YSB A;  2KXQ A;  3PQH A;  1TR8 A;  4QIB A;  3LE4 A;  2XP4 A;  2JXW A;  2Y8N B;  2M8J A;  1EG4 A;  3L4H A;  3FSC A;  4U84 A;  3ODK A;  2DJY A;  3MQG A;  2XP8 A;  1WR7 A;  4E5R A;  2LAJ A;  2M3O W;  4REX A;  3TC5 A;  3FSB A;  5AHT A;  2YSG A;  3KAG A;  2JX8 A;  2ZAJ A;  1PIN A;  1EG3 A;  2F21 A;  3CNG A;  2ZQS A;  2DK1 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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