2MDIA

Solution structure of the pp2ww mutant (kpp2ww) of hypb
Total Genus 2
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
2
sequence length
56
structure length
56
Chain Sequence
GSDLPPPSPPAAATIVLPPNWKTARDPEGKIYYYHVITRQTQWDPPTWESPGDDAS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Transferase
source organism Homo sapiens
publication title Autoinhibitory structure of the WW domain of HYPB/SETD2 regulates its interaction with the proline-rich region of huntingtin.
pubmed doi rcsb
molecule keywords Histone-lysine N-methyltransferase SETD2
total genus 2
structure length 56
sequence length 56
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2013-09-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00397 WW WW domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.20.70.10 Mainly Beta Single Sheet Ubiquitin Ligase Nedd4; Chain: W; Ubiquitin Ligase Nedd4; Chain: W; 2mdiA00
2ZQTA 2ZQVA 2RE3A 2E45A 2YSBA 2JMFA 3KAIA 3LE4A 2ZQUA 3ODKA 2XP5A 2EZ5W 1JMQA 3KAHA 2XP6A 2ZR4A 2DK7A 1K9RA 1WMVA 2DMVA 2ZQSA 3M85A 2DJYA 4U86A 3KAGA 5CQ2A 3TCZA 2ZR5A 2BA1A 4U84A 3NTPA 1WR7A 4U85A 2LAJA 2YSIA 2M3OW 2XP4A 3KCEA 2XP3A 3TDBA 1YW5A 1EG4A 1K9QA 3KAFA 2YSHA 4E5RA 1TK7A 2DK1A 1O6WA 2XPBA 2JXWA 2YSFA 1I5HW 2DWVA 5AHTA 2F21A 3WH0A 3TC5A 1PINA 3M7NA 1ZCNA 2M8JA 2L4JA 3KADA 2MDIA 1EG3A 2XPAA 2KXQA 3OOBA 2ITKA 2XP9A 4REXA 2JX8A 2ZR6A 2JV4A 2ZAJA 2M8IA 1F8AB 2XP7A 2Q5AA 3KABA 3L4HA 4QIBA 2XP8A 3CNGA 1NMVA 2YSGA
chains in the Genus database with same CATH superfamily
2YAJB 2ZQTA 2ZQVA 2RE3A 2E45A 2YSBA 2JMFA 3KAIA 3MCBA 3LE4A 4A0TA 2ZQUA 4GLXA 3ODKA 2XP5A 2EZ5W 1JMQA 3KAHA 2XP6A 5U47A 2ZR4A 3FS8A 2DK7A 1K9RA 1WMVA 2DMVA 3FSBA 2ZQSA 3M85A 2DJYA 4U86A 3MQGA 3KAGA 5CQ2A 3TCZA 2ZR5A 2OWOA 1FLCA 2BA1A 4U84A 3NTPA 3LKXB 1WR7A 4U85A 2LAJA 2YSIA 2M3OW 2XP4A 4A0UA 3KCEA 2WADA 2XP3A 3TDBA 1RP5A 5E64A 1YW5A 1EG4A 1K9QA 3KAFA 2YSHA 4E5RA 1TK7A 2DK1A 1O6WA 2XPBA 2JXWA 2YSFA 1I5HW 2DWVA 5AHTA 2F21A 5E66A 3WH0A 3TC5A 1PINA 3M7NA 1ZCNA 2M8JA 2L4JA 3KADA 2MDIA 3MCBB 1EG3A 1TR8A 2XPAA 2KXQA 3OOBA 2ITKA 2XP9A 2QRVA 5E65A 3LKXA 2Y8NB 4REXA 2JX8A 3FSCA 2ZR6A 2JV4A 5E62A 5E5WA 2ZAJA 2M8IA 2WAEA 1F8AB 2XP7A 2Q5AA 3PQHA 3KABA 3L4HA 4QIBA 3MQHA 2XP8A 3CNGA 1NMVA 2YSGA
chains in the Genus database with same CATH topology
2YAJB 2ZQTA 2ZQVA 2RE3A 2E45A 2YSBA 2JMFA 3KAIA 3MCBA 3LE4A 4A0TA 2ZQUA 4GLXA 3ODKA 2XP5A 2EZ5W 1JMQA 3KAHA 2XP6A 5U47A 2ZR4A 3FS8A 2DK7A 1K9RA 1WMVA 2DMVA 3FSBA 2ZQSA 3M85A 2DJYA 4U86A 3MQGA 3KAGA 5CQ2A 3TCZA 2ZR5A 2OWOA 1FLCA 2BA1A 4U84A 3NTPA 3LKXB 1WR7A 4U85A 2LAJA 2YSIA 2M3OW 2XP4A 4A0UA 3KCEA 2WADA 2XP3A 3TDBA 1RP5A 5E64A 1YW5A 1EG4A 1K9QA 3KAFA 2YSHA 4E5RA 1TK7A 2DK1A 1O6WA 2XPBA 2JXWA 2YSFA 1I5HW 2DWVA 5AHTA 2F21A 5E66A 3WH0A 3TC5A 1PINA 3M7NA 1ZCNA 2M8JA 2L4JA 3KADA 2MDIA 3MCBB 1EG3A 1TR8A 2XPAA 2KXQA 3OOBA 2ITKA 2XP9A 2QRVA 5E65A 3LKXA 2Y8NB 4REXA 2JX8A 3FSCA 2ZR6A 2JV4A 5E62A 5E5WA 2ZAJA 2M8IA 2WAEA 1F8AB 2XP7A 2Q5AA 3PQHA 3KABA 3L4HA 4QIBA 3MQHA 2XP8A 3CNGA 1NMVA 2YSGA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2ZQT A;  2ZQV A;  2RE3 A;  2E45 A;  2YSB A;  2JMF A;  3KAI A;  3LE4 A;  2ZQU A;  3ODK A;  2XP5 A;  2EZ5 W;  1JMQ A;  3KAH A;  2XP6 A;  2ZR4 A;  2DK7 A;  1K9R A;  1WMV A;  2DMV A;  2ZQS A;  3M85 A;  2DJY A;  4U86 A;  3KAG A;  5CQ2 A;  3TCZ A;  2ZR5 A;  2BA1 A;  4U84 A;  3NTP A;  1WR7 A;  4U85 A;  2LAJ A;  2YSI A;  2M3O W;  2XP4 A;  3KCE A;  2XP3 A;  3TDB A;  1YW5 A;  1EG4 A;  1K9Q A;  3KAF A;  2YSH A;  4E5R A;  1TK7 A;  2DK1 A;  1O6W A;  2XPB A;  2JXW A;  2YSF A;  1I5H W;  2DWV A;  5AHT A;  2F21 A;  3WH0 A;  3TC5 A;  1PIN A;  3M7N A;  1ZCN A;  2M8J A;  2L4J A;  3KAD A;  2MDI A;  1EG3 A;  2XPA A;  2KXQ A;  3OOB A;  2ITK A;  2XP9 A;  4REX A;  2JX8 A;  2ZR6 A;  2JV4 A;  2ZAJ A;  2M8I A;  1F8A B;  2XP7 A;  2Q5A A;  3KAB A;  3L4H A;  4QIB A;  2XP8 A;  3CNG A;  1NMV A;  2YSG A; 
#chains in the Genus database with same CATH topology
 2YAJ B;  2ZQT A;  2ZQV A;  2RE3 A;  2E45 A;  2YSB A;  2JMF A;  3KAI A;  3MCB A;  3LE4 A;  4A0T A;  2ZQU A;  4GLX A;  3ODK A;  2XP5 A;  2EZ5 W;  1JMQ A;  3KAH A;  2XP6 A;  5U47 A;  2ZR4 A;  3FS8 A;  2DK7 A;  1K9R A;  1WMV A;  2DMV A;  3FSB A;  2ZQS A;  3M85 A;  2DJY A;  4U86 A;  3MQG A;  3KAG A;  5CQ2 A;  3TCZ A;  2ZR5 A;  2OWO A;  1FLC A;  2BA1 A;  4U84 A;  3NTP A;  3LKX B;  1WR7 A;  4U85 A;  2LAJ A;  2YSI A;  2M3O W;  2XP4 A;  4A0U A;  3KCE A;  2WAD A;  2XP3 A;  3TDB A;  1RP5 A;  5E64 A;  1YW5 A;  1EG4 A;  1K9Q A;  3KAF A;  2YSH A;  4E5R A;  1TK7 A;  2DK1 A;  1O6W A;  2XPB A;  2JXW A;  2YSF A;  1I5H W;  2DWV A;  5AHT A;  2F21 A;  5E66 A;  3WH0 A;  3TC5 A;  1PIN A;  3M7N A;  1ZCN A;  2M8J A;  2L4J A;  3KAD A;  2MDI A;  3MCB B;  1EG3 A;  1TR8 A;  2XPA A;  2KXQ A;  3OOB A;  2ITK A;  2XP9 A;  2QRV A;  5E65 A;  3LKX A;  2Y8N B;  4REX A;  2JX8 A;  3FSC A;  2ZR6 A;  2JV4 A;  5E62 A;  5E5W A;  2ZAJ A;  2M8I A;  2WAE A;  1F8A B;  2XP7 A;  2Q5A A;  3PQH A;  3KAB A;  3L4H A;  4QIB A;  3MQH A;  2XP8 A;  3CNG A;  1NMV A;  2YSG A; 
#chains in the Genus database with same CATH homology
 2YAJ B;  2ZQT A;  2ZQV A;  2RE3 A;  2E45 A;  2YSB A;  2JMF A;  3KAI A;  3MCB A;  3LE4 A;  4A0T A;  2ZQU A;  4GLX A;  3ODK A;  2XP5 A;  2EZ5 W;  1JMQ A;  3KAH A;  2XP6 A;  5U47 A;  2ZR4 A;  3FS8 A;  2DK7 A;  1K9R A;  1WMV A;  2DMV A;  3FSB A;  2ZQS A;  3M85 A;  2DJY A;  4U86 A;  3MQG A;  3KAG A;  5CQ2 A;  3TCZ A;  2ZR5 A;  2OWO A;  1FLC A;  2BA1 A;  4U84 A;  3NTP A;  3LKX B;  1WR7 A;  4U85 A;  2LAJ A;  2YSI A;  2M3O W;  2XP4 A;  4A0U A;  3KCE A;  2WAD A;  2XP3 A;  3TDB A;  1RP5 A;  5E64 A;  1YW5 A;  1EG4 A;  1K9Q A;  3KAF A;  2YSH A;  4E5R A;  1TK7 A;  2DK1 A;  1O6W A;  2XPB A;  2JXW A;  2YSF A;  1I5H W;  2DWV A;  5AHT A;  2F21 A;  5E66 A;  3WH0 A;  3TC5 A;  1PIN A;  3M7N A;  1ZCN A;  2M8J A;  2L4J A;  3KAD A;  2MDI A;  3MCB B;  1EG3 A;  1TR8 A;  2XPA A;  2KXQ A;  3OOB A;  2ITK A;  2XP9 A;  2QRV A;  5E65 A;  3LKX A;  2Y8N B;  4REX A;  2JX8 A;  3FSC A;  2ZR6 A;  2JV4 A;  5E62 A;  5E5W A;  2ZAJ A;  2M8I A;  2WAE A;  1F8A B;  2XP7 A;  2Q5A A;  3PQH A;  3KAB A;  3L4H A;  4QIB A;  3MQH A;  2XP8 A;  3CNG A;  1NMV A;  2YSG A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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