2MDIA

Solution structure of the pp2ww mutant (kpp2ww) of hypb
Total Genus 2
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
2
sequence length
56
structure length
56
Chain Sequence
GSDLPPPSPPAAATIVLPPNWKTARDPEGKIYYYHVITRQTQWDPPTWESPGDDAS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Autoinhibitory structure of the WW domain of HYPB/SETD2 regulates its interaction with the proline-rich region of huntingtin.
pubmed doi rcsb
molecule tags Transferase
source organism Homo sapiens
molecule keywords Histone-lysine N-methyltransferase SETD2
total genus 2
structure length 56
sequence length 56
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2013-09-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00397 WW WW domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.20.70.10 Mainly Beta Single Sheet Ubiquitin Ligase Nedd4; Chain: W; Ubiquitin Ligase Nedd4; Chain: W; 2mdiA00
2EZ5W 2DK1A 1F8AB 1O6WA 2XPBA 1K9QA 1TK7A 2ZQUA 2ZQTA 3KCEA 3KAFA 1I5HW 3KADA 3NTPA 2M8IA 3OOBA 1JMQA 2M8JA 2JV4A 3WH0A 4U86A 3L4HA 2ZR6A 1K9RA 2LAJA 5CQ2A 2YSIA 2XP4A 2XP7A 1EG3A 2YSBA 2JMFA 1WR7A 4U85A 2XPAA 3TDBA 3M85A 4QIBA 2F21A 3TC5A 3KAHA 3LE4A 3M7NA 2XP9A 2JX8A 3TCZA 2XP6A 3KABA 3CNGA 2ZQVA 2DJYA 2YSHA 2YSGA 2KXQA 1YW5A 2DWVA 5AHTA 2Q5AA 1EG4A 2RE3A 2L4JA 2ZR4A 2BA1A 4REXA 4E5RA 2DK7A 3KAIA 2XP8A 3KAGA 2ZAJA 1NMVA 2ZQSA 3ODKA 1PINA 2ITKA 2ZR5A 2M3OW 1ZCNA 2JXWA 1WMVA 2DMVA 2XP3A 2XP5A 2YSFA 2E45A 2MDIA 4U84A
chains in the Genus database with same CATH superfamily
2EZ5W 3FSBA 2DK1A 1F8AB 5E5WA 1O6WA 2XPBA 1K9QA 1TK7A 2ZQUA 3LKXA 2ZQTA 3KCEA 3KAFA 2YAJB 1I5HW 3MCBA 3KADA 3NTPA 2M8IA 3OOBA 1RP5A 1JMQA 2M8JA 1TR8A 2JV4A 2QRVA 3WH0A 3MQGA 4U86A 3L4HA 2ZR6A 1K9RA 3FS8A 2LAJA 5CQ2A 2YSIA 2XP4A 3FSCA 2XP7A 1EG3A 2YSBA 2JMFA 1WR7A 4U85A 5E65A 4A0TA 5E62A 2XPAA 3TDBA 3M85A 4QIBA 2F21A 2Y8NB 3TC5A 3KAHA 3LE4A 3M7NA 2XP9A 2JX8A 3TCZA 5U47A 2XP6A 3KABA 5E64A 3CNGA 2ZQVA 2DJYA 2YSHA 2YSGA 2KXQA 5E66A 3LKXB 1YW5A 2DWVA 5AHTA 2Q5AA 1EG4A 2WADA 2RE3A 2L4JA 2ZR4A 2BA1A 2WAEA 3MCBB 4REXA 4E5RA 2DK7A 2OWOA 3KAIA 4GLXA 2XP8A 3MQHA 3KAGA 2ZAJA 1NMVA 2ZQSA 3ODKA 1PINA 2ITKA 1FLCA 3PQHA 2ZR5A 2M3OW 1ZCNA 2JXWA 4A0UA 1WMVA 2DMVA 2XP3A 2XP5A 2YSFA 2E45A 2MDIA 4U84A
chains in the Genus database with same CATH topology
2EZ5W 3FSBA 2DK1A 1F8AB 5E5WA 1O6WA 2XPBA 1K9QA 1TK7A 2ZQUA 3LKXA 2ZQTA 3KCEA 3KAFA 2YAJB 1I5HW 3MCBA 3KADA 3NTPA 2M8IA 3OOBA 1RP5A 1JMQA 2M8JA 1TR8A 2JV4A 2QRVA 3WH0A 3MQGA 4U86A 3L4HA 2ZR6A 1K9RA 3FS8A 2LAJA 5CQ2A 2YSIA 2XP4A 3FSCA 2XP7A 1EG3A 2YSBA 2JMFA 1WR7A 4U85A 5E65A 4A0TA 5E62A 2XPAA 3TDBA 3M85A 4QIBA 2F21A 2Y8NB 3TC5A 3KAHA 3LE4A 3M7NA 2XP9A 2JX8A 3TCZA 5U47A 2XP6A 3KABA 5E64A 3CNGA 2ZQVA 2DJYA 2YSHA 2YSGA 2KXQA 5E66A 3LKXB 1YW5A 2DWVA 5AHTA 2Q5AA 1EG4A 2WADA 2RE3A 2L4JA 2ZR4A 2BA1A 2WAEA 3MCBB 4REXA 4E5RA 2DK7A 2OWOA 3KAIA 4GLXA 2XP8A 3MQHA 3KAGA 2ZAJA 1NMVA 2ZQSA 3ODKA 1PINA 2ITKA 1FLCA 3PQHA 2ZR5A 2M3OW 1ZCNA 2JXWA 4A0UA 1WMVA 2DMVA 2XP3A 2XP5A 2YSFA 2E45A 2MDIA 4U84A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2EZ5 W;  2DK1 A;  1F8A B;  1O6W A;  2XPB A;  1K9Q A;  1TK7 A;  2ZQU A;  2ZQT A;  3KCE A;  3KAF A;  1I5H W;  3KAD A;  3NTP A;  2M8I A;  3OOB A;  1JMQ A;  2M8J A;  2JV4 A;  3WH0 A;  4U86 A;  3L4H A;  2ZR6 A;  1K9R A;  2LAJ A;  5CQ2 A;  2YSI A;  2XP4 A;  2XP7 A;  1EG3 A;  2YSB A;  2JMF A;  1WR7 A;  4U85 A;  2XPA A;  3TDB A;  3M85 A;  4QIB A;  2F21 A;  3TC5 A;  3KAH A;  3LE4 A;  3M7N A;  2XP9 A;  2JX8 A;  3TCZ A;  2XP6 A;  3KAB A;  3CNG A;  2ZQV A;  2DJY A;  2YSH A;  2YSG A;  2KXQ A;  1YW5 A;  2DWV A;  5AHT A;  2Q5A A;  1EG4 A;  2RE3 A;  2L4J A;  2ZR4 A;  2BA1 A;  4REX A;  4E5R A;  2DK7 A;  3KAI A;  2XP8 A;  3KAG A;  2ZAJ A;  1NMV A;  2ZQS A;  3ODK A;  1PIN A;  2ITK A;  2ZR5 A;  2M3O W;  1ZCN A;  2JXW A;  1WMV A;  2DMV A;  2XP3 A;  2XP5 A;  2YSF A;  2E45 A;  2MDI A;  4U84 A; 
#chains in the Genus database with same CATH topology
 2EZ5 W;  3FSB A;  2DK1 A;  1F8A B;  5E5W A;  1O6W A;  2XPB A;  1K9Q A;  1TK7 A;  2ZQU A;  3LKX A;  2ZQT A;  3KCE A;  3KAF A;  2YAJ B;  1I5H W;  3MCB A;  3KAD A;  3NTP A;  2M8I A;  3OOB A;  1RP5 A;  1JMQ A;  2M8J A;  1TR8 A;  2JV4 A;  2QRV A;  3WH0 A;  3MQG A;  4U86 A;  3L4H A;  2ZR6 A;  1K9R A;  3FS8 A;  2LAJ A;  5CQ2 A;  2YSI A;  2XP4 A;  3FSC A;  2XP7 A;  1EG3 A;  2YSB A;  2JMF A;  1WR7 A;  4U85 A;  5E65 A;  4A0T A;  5E62 A;  2XPA A;  3TDB A;  3M85 A;  4QIB A;  2F21 A;  2Y8N B;  3TC5 A;  3KAH A;  3LE4 A;  3M7N A;  2XP9 A;  2JX8 A;  3TCZ A;  5U47 A;  2XP6 A;  3KAB A;  5E64 A;  3CNG A;  2ZQV A;  2DJY A;  2YSH A;  2YSG A;  2KXQ A;  5E66 A;  3LKX B;  1YW5 A;  2DWV A;  5AHT A;  2Q5A A;  1EG4 A;  2WAD A;  2RE3 A;  2L4J A;  2ZR4 A;  2BA1 A;  2WAE A;  3MCB B;  4REX A;  4E5R A;  2DK7 A;  2OWO A;  3KAI A;  4GLX A;  2XP8 A;  3MQH A;  3KAG A;  2ZAJ A;  1NMV A;  2ZQS A;  3ODK A;  1PIN A;  2ITK A;  1FLC A;  3PQH A;  2ZR5 A;  2M3O W;  1ZCN A;  2JXW A;  4A0U A;  1WMV A;  2DMV A;  2XP3 A;  2XP5 A;  2YSF A;  2E45 A;  2MDI A;  4U84 A; 
#chains in the Genus database with same CATH homology
 2EZ5 W;  3FSB A;  2DK1 A;  1F8A B;  5E5W A;  1O6W A;  2XPB A;  1K9Q A;  1TK7 A;  2ZQU A;  3LKX A;  2ZQT A;  3KCE A;  3KAF A;  2YAJ B;  1I5H W;  3MCB A;  3KAD A;  3NTP A;  2M8I A;  3OOB A;  1RP5 A;  1JMQ A;  2M8J A;  1TR8 A;  2JV4 A;  2QRV A;  3WH0 A;  3MQG A;  4U86 A;  3L4H A;  2ZR6 A;  1K9R A;  3FS8 A;  2LAJ A;  5CQ2 A;  2YSI A;  2XP4 A;  3FSC A;  2XP7 A;  1EG3 A;  2YSB A;  2JMF A;  1WR7 A;  4U85 A;  5E65 A;  4A0T A;  5E62 A;  2XPA A;  3TDB A;  3M85 A;  4QIB A;  2F21 A;  2Y8N B;  3TC5 A;  3KAH A;  3LE4 A;  3M7N A;  2XP9 A;  2JX8 A;  3TCZ A;  5U47 A;  2XP6 A;  3KAB A;  5E64 A;  3CNG A;  2ZQV A;  2DJY A;  2YSH A;  2YSG A;  2KXQ A;  5E66 A;  3LKX B;  1YW5 A;  2DWV A;  5AHT A;  2Q5A A;  1EG4 A;  2WAD A;  2RE3 A;  2L4J A;  2ZR4 A;  2BA1 A;  2WAE A;  3MCB B;  4REX A;  4E5R A;  2DK7 A;  2OWO A;  3KAI A;  4GLX A;  2XP8 A;  3MQH A;  3KAG A;  2ZAJ A;  1NMV A;  2ZQS A;  3ODK A;  1PIN A;  2ITK A;  1FLC A;  3PQH A;  2ZR5 A;  2M3O W;  1ZCN A;  2JXW A;  4A0U A;  1WMV A;  2DMV A;  2XP3 A;  2XP5 A;  2YSF A;  2E45 A;  2MDI A;  4U84 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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