2YSF | Genus

Total Genus 1

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	1
sequence length	40
structure length	40
Chain Sequence	GSSGSSGLPEGWEMRFTVDGIPYFVDHNRRTTTYIDPRTG

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

molecule tags	Protein binding
source organism	Homo sapiens
publication title	Solution structure of the fourth WW domain from the human E3 ubiquitin-protein ligase Itchy homolog, ITCH rcsb
molecule keywords	E3 ubiquitin-protein ligase Itchy homolog
total genus	1
structure length	40
sequence length	40
ec nomenclature	ec 2.3.2.26: HECT-type E3 ubiquitin transferase.
pdb deposition date	2007-04-03

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF00397	WW	WW domain

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
2.20.70.10	Mainly Beta	Single Sheet	Ubiquitin Ligase Nedd4; Chain: W;	Ubiquitin Ligase Nedd4; Chain: W;	2ysfA01

3OOBA 2ZQUA 2ZR6A 1TK7A 1NMVA 3KCEA 4U85A 3KAIA 2ZQTA 1EG4A 3LE4A 2XP9A 2DJYA 3KAHA 2DWVA 3KADA 2JMFA 2XP6A 1K9RA 3TC5A 2EZ5W 4QIBA 1JMQA 2JXWA 1I5HW 2BA1A 2DK1A 2M8JA 2RE3A 2DK7A 4U84A 1YW5A 5CQ2A 5AHTA 3TDBA 2E45A 1WMVA 2XP5A 1O6WA 1PINA 2XP7A 2XPBA 3TCZA 2XP3A 2YSGA 2LAJA 2JX8A 2XP4A 2MDIA 2ZQSA 2YSHA 3KAFA 1WR7A 3M85A 2ZAJA 2KXQA 1K9QA 4U86A 1EG3A 2ZR5A 2DMVA 2YSFA 2Q5AA 3NTPA 3M7NA 1ZCNA 3L4HA 2XPAA 2XP8A 3KABA 2YSBA 2ITKA 3WH0A 3CNGA 2ZR4A 2M8IA 2L4JA 2ZQVA 2M3OW 1F8AB 3KAGA 2YSIA 4E5RA 4REXA 2F21A 2JV4A 3ODKA
chains in the Genus database with same CATH superfamily

3OOBA 2ZQUA 2ZR6A 1TK7A 1NMVA 3KCEA 4U85A 3KAIA 2WAEA 2ZQTA 5E66A 1EG4A 3LE4A 2XP9A 2DJYA 3KAHA 2DWVA 3KADA 2JMFA 2XP6A 1K9RA 3TC5A 3MQHA 2EZ5W 4QIBA 1JMQA 5U47A 2JXWA 1I5HW 2BA1A 2DK1A 2M8JA 2RE3A 2DK7A 4U84A 1YW5A 5CQ2A 5E64A 5AHTA 3TDBA 2E45A 1WMVA 2XP5A 1O6WA 3FS8A 1PINA 4A0TA 2XP7A 4A0UA 2QRVA 2XPBA 3TCZA 2XP3A 2YSGA 2LAJA 1RP5A 2JX8A 2XP4A 3FSCA 3MQGA 2MDIA 2Y8NB 2ZQSA 2YSHA 3KAFA 1WR7A 3M85A 2ZAJA 2KXQA 4GLXA 4U86A 1K9QA 1EG3A 2ZR5A 2DMVA 2YSFA 3LKXA 2Q5AA 3NTPA 3M7NA 1ZCNA 3L4HA 2XPAA 2XP8A 3KABA 2YSBA 2ITKA 3MCBB 3WH0A 3CNGA 2ZR4A 5E62A 2M8IA 3LKXB 3FSBA 2L4JA 3PQHA 2ZQVA 2M3OW 2WADA 1FLCA 1F8AB 5E5WA 3KAGA 3MCBA 2YSIA 2YAJB 5E65A 4E5RA 2OWOA 4REXA 2F21A 2JV4A 1TR8A 3ODKA
chains in the Genus database with same CATH topology

#chains in the Genus database with same CATH superfamily
 3OOB A;  2ZQU A;  2ZR6 A;  1TK7 A;  1NMV A;  3KCE A;  4U85 A;  3KAI A;  2ZQT A;  1EG4 A;  3LE4 A;  2XP9 A;  2DJY A;  3KAH A;  2DWV A;  3KAD A;  2JMF A;  2XP6 A;  1K9R A;  3TC5 A;  2EZ5 W;  4QIB A;  1JMQ A;  2JXW A;  1I5H W;  2BA1 A;  2DK1 A;  2M8J A;  2RE3 A;  2DK7 A;  4U84 A;  1YW5 A;  5CQ2 A;  5AHT A;  3TDB A;  2E45 A;  1WMV A;  2XP5 A;  1O6W A;  1PIN A;  2XP7 A;  2XPB A;  3TCZ A;  2XP3 A;  2YSG A;  2LAJ A;  2JX8 A;  2XP4 A;  2MDI A;  2ZQS A;  2YSH A;  3KAF A;  1WR7 A;  3M85 A;  2ZAJ A;  2KXQ A;  1K9Q A;  4U86 A;  1EG3 A;  2ZR5 A;  2DMV A;  2YSF A;  2Q5A A;  3NTP A;  3M7N A;  1ZCN A;  3L4H A;  2XPA A;  2XP8 A;  3KAB A;  2YSB A;  2ITK A;  3WH0 A;  3CNG A;  2ZR4 A;  2M8I A;  2L4J A;  2ZQV A;  2M3O W;  1F8A B;  3KAG A;  2YSI A;  4E5R A;  4REX A;  2F21 A;  2JV4 A;  3ODK A; 
#chains in the Genus database with same CATH topology
 3OOB A;  2ZQU A;  2ZR6 A;  1TK7 A;  1NMV A;  3KCE A;  4U85 A;  3KAI A;  2WAE A;  2ZQT A;  5E66 A;  1EG4 A;  3LE4 A;  2XP9 A;  2DJY A;  3KAH A;  2DWV A;  3KAD A;  2JMF A;  2XP6 A;  1K9R A;  3TC5 A;  3MQH A;  2EZ5 W;  4QIB A;  1JMQ A;  5U47 A;  2JXW A;  1I5H W;  2BA1 A;  2DK1 A;  2M8J A;  2RE3 A;  2DK7 A;  4U84 A;  1YW5 A;  5CQ2 A;  5E64 A;  5AHT A;  3TDB A;  2E45 A;  1WMV A;  2XP5 A;  1O6W A;  3FS8 A;  1PIN A;  4A0T A;  2XP7 A;  4A0U A;  2QRV A;  2XPB A;  3TCZ A;  2XP3 A;  2YSG A;  2LAJ A;  1RP5 A;  2JX8 A;  2XP4 A;  3FSC A;  3MQG A;  2MDI A;  2Y8N B;  2ZQS A;  2YSH A;  3KAF A;  1WR7 A;  3M85 A;  2ZAJ A;  2KXQ A;  4GLX A;  4U86 A;  1K9Q A;  1EG3 A;  2ZR5 A;  2DMV A;  2YSF A;  3LKX A;  2Q5A A;  3NTP A;  3M7N A;  1ZCN A;  3L4H A;  2XPA A;  2XP8 A;  3KAB A;  2YSB A;  2ITK A;  3MCB B;  3WH0 A;  3CNG A;  2ZR4 A;  5E62 A;  2M8I A;  3LKX B;  3FSB A;  2L4J A;  3PQH A;  2ZQV A;  2M3O W;  2WAD A;  1FLC A;  1F8A B;  5E5W A;  3KAG A;  3MCB A;  2YSI A;  2YAJ B;  5E65 A;  4E5R A;  2OWO A;  4REX A;  2F21 A;  2JV4 A;  1TR8 A;  3ODK A; 
#chains in the Genus database with same CATH homology
 3OOB A;  2ZQU A;  2ZR6 A;  1TK7 A;  1NMV A;  3KCE A;  4U85 A;  3KAI A;  2WAE A;  2ZQT A;  5E66 A;  1EG4 A;  3LE4 A;  2XP9 A;  2DJY A;  3KAH A;  2DWV A;  3KAD A;  2JMF A;  2XP6 A;  1K9R A;  3TC5 A;  3MQH A;  2EZ5 W;  4QIB A;  1JMQ A;  5U47 A;  2JXW A;  1I5H W;  2BA1 A;  2DK1 A;  2M8J A;  2RE3 A;  2DK7 A;  4U84 A;  1YW5 A;  5CQ2 A;  5E64 A;  5AHT A;  3TDB A;  2E45 A;  1WMV A;  2XP5 A;  1O6W A;  3FS8 A;  1PIN A;  4A0T A;  2XP7 A;  4A0U A;  2QRV A;  2XPB A;  3TCZ A;  2XP3 A;  2YSG A;  2LAJ A;  1RP5 A;  2JX8 A;  2XP4 A;  3FSC A;  3MQG A;  2MDI A;  2Y8N B;  2ZQS A;  2YSH A;  3KAF A;  1WR7 A;  3M85 A;  2ZAJ A;  2KXQ A;  4GLX A;  4U86 A;  1K9Q A;  1EG3 A;  2ZR5 A;  2DMV A;  2YSF A;  3LKX A;  2Q5A A;  3NTP A;  3M7N A;  1ZCN A;  3L4H A;  2XPA A;  2XP8 A;  3KAB A;  2YSB A;  2ITK A;  3MCB B;  3WH0 A;  3CNG A;  2ZR4 A;  5E62 A;  2M8I A;  3LKX B;  3FSB A;  2L4J A;  3PQH A;  2ZQV A;  2M3O W;  2WAD A;  1FLC A;  1F8A B;  5E5W A;  3KAG A;  3MCB A;  2YSI A;  2YAJ B;  5E65 A;  4E5R A;  2OWO A;  4REX A;  2F21 A;  2JV4 A;  1TR8 A;  3ODK A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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2YSFA

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations