2YSFA

Solution structure of the fourth ww domain from the human e3 ubiquitin-protein ligase itchy homolog, itch
Total Genus 1
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
1
sequence length
40
structure length
40
Chain Sequence
GSSGSSGLPEGWEMRFTVDGIPYFVDHNRRTTTYIDPRTG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Protein binding
source organism Homo sapiens
publication title Solution structure of the fourth WW domain from the human E3 ubiquitin-protein ligase Itchy homolog, ITCH
rcsb
molecule keywords E3 ubiquitin-protein ligase Itchy homolog
total genus 1
structure length 40
sequence length 40
ec nomenclature ec 2.3.2.26: HECT-type E3 ubiquitin transferase.
pdb deposition date 2007-04-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00397 WW WW domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.20.70.10 Mainly Beta Single Sheet Ubiquitin Ligase Nedd4; Chain: W; Ubiquitin Ligase Nedd4; Chain: W; 2ysfA01
2ZQUA 1ZCNA 3M85A 1F8AB 4U86A 3KAFA 3KAHA 5CQ2A 2YSHA 2YSGA 2DWVA 1TK7A 2M3OW 1PINA 2JMFA 2XP8A 2JXWA 2XP7A 2EZ5W 2DMVA 3KAGA 3M7NA 1YW5A 2DK1A 3TDBA 4E5RA 2M8IA 3OOBA 1K9QA 5AHTA 2YSFA 2M8JA 3WH0A 3LE4A 3TC5A 1WMVA 2KXQA 1JMQA 1EG3A 2JV4A 3ODKA 2MDIA 3KAIA 1O6WA 1I5HW 2ITKA 2ZQTA 4QIBA 4U84A 2DJYA 2RE3A 3L4HA 2L4JA 2DK7A 1WR7A 3NTPA 4U85A 3KABA 2ZR4A 2ZR6A 3TCZA 2E45A 2XPBA 1K9RA 3CNGA 2ZAJA 1EG4A 3KADA 2Q5AA 2BA1A 3KCEA 2JX8A 2F21A 2LAJA 2XP3A 4REXA 2ZR5A 2XPAA 2YSBA 2XP5A 2ZQVA 2XP6A 1NMVA 2YSIA 2XP9A 2XP4A 2ZQSA
chains in the Genus database with same CATH superfamily
2ZQUA 3MCBB 1ZCNA 3M85A 4A0UA 1F8AB 4U86A 3KAFA 3KAHA 5CQ2A 2YSHA 2YSGA 2DWVA 1TK7A 2M3OW 1PINA 2JMFA 2XP8A 5E5WA 2JXWA 3FSBA 2XP7A 2EZ5W 2DMVA 2Y8NB 1RP5A 3KAGA 3M7NA 1YW5A 2DK1A 3TDBA 4E5RA 2M8IA 3OOBA 1K9QA 5AHTA 2YSFA 2M8JA 5E62A 3WH0A 3LE4A 3TC5A 1WMVA 2KXQA 1JMQA 1EG3A 4A0TA 2JV4A 3ODKA 2MDIA 2WADA 3MQHA 3KAIA 1O6WA 1I5HW 2ITKA 5U47A 2ZQTA 3FSCA 3LKXA 4QIBA 4U84A 2DJYA 2RE3A 4GLXA 2OWOA 3L4HA 2L4JA 2DK7A 3PQHA 1WR7A 3NTPA 4U85A 3KABA 2ZR4A 2ZR6A 3LKXB 3TCZA 2E45A 2QRVA 2XPBA 1K9RA 3CNGA 2ZAJA 1EG4A 3KADA 2Q5AA 5E64A 1FLCA 3MQGA 2BA1A 3KCEA 2JX8A 2F21A 2LAJA 2XP3A 5E66A 4REXA 2ZR5A 2XPAA 3MCBA 2YSBA 2XP5A 3FS8A 2ZQVA 1TR8A 2XP6A 5E65A 1NMVA 2YSIA 2XP9A 2XP4A 2YAJB 2WAEA 2ZQSA
chains in the Genus database with same CATH topology
2ZQUA 3MCBB 1ZCNA 3M85A 4A0UA 1F8AB 4U86A 3KAFA 3KAHA 5CQ2A 2YSHA 2YSGA 2DWVA 1TK7A 2M3OW 1PINA 2JMFA 2XP8A 5E5WA 2JXWA 3FSBA 2XP7A 2EZ5W 2DMVA 2Y8NB 1RP5A 3KAGA 3M7NA 1YW5A 2DK1A 3TDBA 4E5RA 2M8IA 3OOBA 1K9QA 5AHTA 2YSFA 2M8JA 5E62A 3WH0A 3LE4A 3TC5A 1WMVA 2KXQA 1JMQA 1EG3A 4A0TA 2JV4A 3ODKA 2MDIA 2WADA 3MQHA 3KAIA 1O6WA 1I5HW 2ITKA 5U47A 2ZQTA 3FSCA 3LKXA 4QIBA 4U84A 2DJYA 2RE3A 4GLXA 2OWOA 3L4HA 2L4JA 2DK7A 3PQHA 1WR7A 3NTPA 4U85A 3KABA 2ZR4A 2ZR6A 3LKXB 3TCZA 2E45A 2QRVA 2XPBA 1K9RA 3CNGA 2ZAJA 1EG4A 3KADA 2Q5AA 5E64A 1FLCA 3MQGA 2BA1A 3KCEA 2JX8A 2F21A 2LAJA 2XP3A 5E66A 4REXA 2ZR5A 2XPAA 3MCBA 2YSBA 2XP5A 3FS8A 2ZQVA 1TR8A 2XP6A 5E65A 1NMVA 2YSIA 2XP9A 2XP4A 2YAJB 2WAEA 2ZQSA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2ZQU A;  1ZCN A;  3M85 A;  1F8A B;  4U86 A;  3KAF A;  3KAH A;  5CQ2 A;  2YSH A;  2YSG A;  2DWV A;  1TK7 A;  2M3O W;  1PIN A;  2JMF A;  2XP8 A;  2JXW A;  2XP7 A;  2EZ5 W;  2DMV A;  3KAG A;  3M7N A;  1YW5 A;  2DK1 A;  3TDB A;  4E5R A;  2M8I A;  3OOB A;  1K9Q A;  5AHT A;  2YSF A;  2M8J A;  3WH0 A;  3LE4 A;  3TC5 A;  1WMV A;  2KXQ A;  1JMQ A;  1EG3 A;  2JV4 A;  3ODK A;  2MDI A;  3KAI A;  1O6W A;  1I5H W;  2ITK A;  2ZQT A;  4QIB A;  4U84 A;  2DJY A;  2RE3 A;  3L4H A;  2L4J A;  2DK7 A;  1WR7 A;  3NTP A;  4U85 A;  3KAB A;  2ZR4 A;  2ZR6 A;  3TCZ A;  2E45 A;  2XPB A;  1K9R A;  3CNG A;  2ZAJ A;  1EG4 A;  3KAD A;  2Q5A A;  2BA1 A;  3KCE A;  2JX8 A;  2F21 A;  2LAJ A;  2XP3 A;  4REX A;  2ZR5 A;  2XPA A;  2YSB A;  2XP5 A;  2ZQV A;  2XP6 A;  1NMV A;  2YSI A;  2XP9 A;  2XP4 A;  2ZQS A; 
#chains in the Genus database with same CATH topology
 2ZQU A;  3MCB B;  1ZCN A;  3M85 A;  4A0U A;  1F8A B;  4U86 A;  3KAF A;  3KAH A;  5CQ2 A;  2YSH A;  2YSG A;  2DWV A;  1TK7 A;  2M3O W;  1PIN A;  2JMF A;  2XP8 A;  5E5W A;  2JXW A;  3FSB A;  2XP7 A;  2EZ5 W;  2DMV A;  2Y8N B;  1RP5 A;  3KAG A;  3M7N A;  1YW5 A;  2DK1 A;  3TDB A;  4E5R A;  2M8I A;  3OOB A;  1K9Q A;  5AHT A;  2YSF A;  2M8J A;  5E62 A;  3WH0 A;  3LE4 A;  3TC5 A;  1WMV A;  2KXQ A;  1JMQ A;  1EG3 A;  4A0T A;  2JV4 A;  3ODK A;  2MDI A;  2WAD A;  3MQH A;  3KAI A;  1O6W A;  1I5H W;  2ITK A;  5U47 A;  2ZQT A;  3FSC A;  3LKX A;  4QIB A;  4U84 A;  2DJY A;  2RE3 A;  4GLX A;  2OWO A;  3L4H A;  2L4J A;  2DK7 A;  3PQH A;  1WR7 A;  3NTP A;  4U85 A;  3KAB A;  2ZR4 A;  2ZR6 A;  3LKX B;  3TCZ A;  2E45 A;  2QRV A;  2XPB A;  1K9R A;  3CNG A;  2ZAJ A;  1EG4 A;  3KAD A;  2Q5A A;  5E64 A;  1FLC A;  3MQG A;  2BA1 A;  3KCE A;  2JX8 A;  2F21 A;  2LAJ A;  2XP3 A;  5E66 A;  4REX A;  2ZR5 A;  2XPA A;  3MCB A;  2YSB A;  2XP5 A;  3FS8 A;  2ZQV A;  1TR8 A;  2XP6 A;  5E65 A;  1NMV A;  2YSI A;  2XP9 A;  2XP4 A;  2YAJ B;  2WAE A;  2ZQS A; 
#chains in the Genus database with same CATH homology
 2ZQU A;  3MCB B;  1ZCN A;  3M85 A;  4A0U A;  1F8A B;  4U86 A;  3KAF A;  3KAH A;  5CQ2 A;  2YSH A;  2YSG A;  2DWV A;  1TK7 A;  2M3O W;  1PIN A;  2JMF A;  2XP8 A;  5E5W A;  2JXW A;  3FSB A;  2XP7 A;  2EZ5 W;  2DMV A;  2Y8N B;  1RP5 A;  3KAG A;  3M7N A;  1YW5 A;  2DK1 A;  3TDB A;  4E5R A;  2M8I A;  3OOB A;  1K9Q A;  5AHT A;  2YSF A;  2M8J A;  5E62 A;  3WH0 A;  3LE4 A;  3TC5 A;  1WMV A;  2KXQ A;  1JMQ A;  1EG3 A;  4A0T A;  2JV4 A;  3ODK A;  2MDI A;  2WAD A;  3MQH A;  3KAI A;  1O6W A;  1I5H W;  2ITK A;  5U47 A;  2ZQT A;  3FSC A;  3LKX A;  4QIB A;  4U84 A;  2DJY A;  2RE3 A;  4GLX A;  2OWO A;  3L4H A;  2L4J A;  2DK7 A;  3PQH A;  1WR7 A;  3NTP A;  4U85 A;  3KAB A;  2ZR4 A;  2ZR6 A;  3LKX B;  3TCZ A;  2E45 A;  2QRV A;  2XPB A;  1K9R A;  3CNG A;  2ZAJ A;  1EG4 A;  3KAD A;  2Q5A A;  5E64 A;  1FLC A;  3MQG A;  2BA1 A;  3KCE A;  2JX8 A;  2F21 A;  2LAJ A;  2XP3 A;  5E66 A;  4REX A;  2ZR5 A;  2XPA A;  3MCB A;  2YSB A;  2XP5 A;  3FS8 A;  2ZQV A;  1TR8 A;  2XP6 A;  5E65 A;  1NMV A;  2YSI A;  2XP9 A;  2XP4 A;  2YAJ B;  2WAE A;  2ZQS A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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