2YSFA

Solution structure of the fourth ww domain from the human e3 ubiquitin-protein ligase itchy homolog, itch
Total Genus 1
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
1
sequence length
40
structure length
40
Chain Sequence
GSSGSSGLPEGWEMRFTVDGIPYFVDHNRRTTTYIDPRTG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Solution structure of the fourth WW domain from the human E3 ubiquitin-protein ligase Itchy homolog, ITCH
rcsb
molecule tags Protein binding
source organism Homo sapiens
molecule keywords E3 ubiquitin-protein ligase Itchy homolog
total genus 1
structure length 40
sequence length 40
ec nomenclature ec 2.3.2.26: HECT-type E3 ubiquitin transferase.
pdb deposition date 2007-04-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00397 WW WW domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.20.70.10 Mainly Beta Single Sheet Ubiquitin Ligase Nedd4; Chain: W; Ubiquitin Ligase Nedd4; Chain: W; 2ysfA01
2M8IA 2YSHA 2ZQUA 5CQ2A 2XP9A 2ZQTA 4U85A 2EZ5W 2XP3A 2KXQA 2ZR5A 2M8JA 2JXWA 2BA1A 3CNGA 4U84A 3KAFA 2YSIA 5AHTA 2DJYA 3KCEA 1PINA 1I5HW 3LE4A 2XP5A 2YSFA 2ZQSA 2ZR6A 2XPAA 2Q5AA 2XP4A 4U86A 3KAHA 1JMQA 1K9RA 4E5RA 3KABA 3KAGA 2XP7A 2JMFA 3KAIA 2ITKA 2M3OW 1TK7A 2XPBA 1NMVA 4REXA 1O6WA 1EG4A 3WH0A 2XP8A 1ZCNA 3M7NA 1EG3A 2DWVA 2YSBA 3ODKA 2DMVA 2JX8A 2YSGA 2XP6A 2MDIA 2F21A 3OOBA 3TC5A 2ZAJA 3TCZA 2DK7A 3L4HA 4QIBA 3KADA 3M85A 1K9QA 2RE3A 1WMVA 2JV4A 1F8AB 2E45A 3TDBA 2LAJA 3NTPA 2ZR4A 2DK1A 1WR7A 2ZQVA 2L4JA 1YW5A
chains in the Genus database with same CATH superfamily
2M8IA 2YSHA 2ZQUA 5CQ2A 5E5WA 2WADA 2XP9A 2ZQTA 4U85A 2EZ5W 2XP3A 2KXQA 2Y8NB 2ZR5A 2M8JA 2JXWA 2BA1A 3CNGA 4U84A 3KAFA 2WAEA 3FSBA 2YSIA 3LKXA 5AHTA 2DJYA 3KCEA 1PINA 1I5HW 2YAJB 1FLCA 3LE4A 2XP5A 2YSFA 2ZQSA 1RP5A 2ZR6A 5E64A 2XPAA 2QRVA 2Q5AA 2XP4A 4U86A 3KAHA 4A0UA 1JMQA 3LKXB 4E5RA 1K9RA 3KABA 3KAGA 2XP7A 2JMFA 3KAIA 2ITKA 5E66A 2M3OW 1TK7A 2XPBA 1NMVA 4REXA 1O6WA 5E62A 1EG4A 4A0TA 3WH0A 2XP8A 1ZCNA 3M7NA 1EG3A 3PQHA 2DWVA 2YSBA 3ODKA 2DMVA 2JX8A 2YSGA 2XP6A 2MDIA 5U47A 2F21A 3MCBA 3OOBA 3TC5A 2ZAJA 3TCZA 3MQGA 2DK7A 2OWOA 3L4HA 4QIBA 5E65A 1TR8A 3FSCA 3KADA 3M85A 1K9QA 2RE3A 1WMVA 2JV4A 1F8AB 2E45A 3MQHA 3TDBA 2LAJA 3NTPA 2ZR4A 3MCBB 2DK1A 4GLXA 1WR7A 2ZQVA 3FS8A 2L4JA 1YW5A
chains in the Genus database with same CATH topology
2M8IA 2YSHA 2ZQUA 5CQ2A 5E5WA 2WADA 2XP9A 2ZQTA 4U85A 2EZ5W 2XP3A 2KXQA 2Y8NB 2ZR5A 2M8JA 2JXWA 2BA1A 3CNGA 4U84A 3KAFA 2WAEA 3FSBA 2YSIA 3LKXA 5AHTA 2DJYA 3KCEA 1PINA 1I5HW 2YAJB 1FLCA 3LE4A 2XP5A 2YSFA 2ZQSA 1RP5A 2ZR6A 5E64A 2XPAA 2QRVA 2Q5AA 2XP4A 4U86A 3KAHA 4A0UA 1JMQA 3LKXB 4E5RA 1K9RA 3KABA 3KAGA 2XP7A 2JMFA 3KAIA 2ITKA 5E66A 2M3OW 1TK7A 2XPBA 1NMVA 4REXA 1O6WA 5E62A 1EG4A 4A0TA 3WH0A 2XP8A 1ZCNA 3M7NA 1EG3A 3PQHA 2DWVA 2YSBA 3ODKA 2DMVA 2JX8A 2YSGA 2XP6A 2MDIA 5U47A 2F21A 3MCBA 3OOBA 3TC5A 2ZAJA 3TCZA 3MQGA 2DK7A 2OWOA 3L4HA 4QIBA 5E65A 1TR8A 3FSCA 3KADA 3M85A 1K9QA 2RE3A 1WMVA 2JV4A 1F8AB 2E45A 3MQHA 3TDBA 2LAJA 3NTPA 2ZR4A 3MCBB 2DK1A 4GLXA 1WR7A 2ZQVA 3FS8A 2L4JA 1YW5A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2M8I A;  2YSH A;  2ZQU A;  5CQ2 A;  2XP9 A;  2ZQT A;  4U85 A;  2EZ5 W;  2XP3 A;  2KXQ A;  2ZR5 A;  2M8J A;  2JXW A;  2BA1 A;  3CNG A;  4U84 A;  3KAF A;  2YSI A;  5AHT A;  2DJY A;  3KCE A;  1PIN A;  1I5H W;  3LE4 A;  2XP5 A;  2YSF A;  2ZQS A;  2ZR6 A;  2XPA A;  2Q5A A;  2XP4 A;  4U86 A;  3KAH A;  1JMQ A;  1K9R A;  4E5R A;  3KAB A;  3KAG A;  2XP7 A;  2JMF A;  3KAI A;  2ITK A;  2M3O W;  1TK7 A;  2XPB A;  1NMV A;  4REX A;  1O6W A;  1EG4 A;  3WH0 A;  2XP8 A;  1ZCN A;  3M7N A;  1EG3 A;  2DWV A;  2YSB A;  3ODK A;  2DMV A;  2JX8 A;  2YSG A;  2XP6 A;  2MDI A;  2F21 A;  3OOB A;  3TC5 A;  2ZAJ A;  3TCZ A;  2DK7 A;  3L4H A;  4QIB A;  3KAD A;  3M85 A;  1K9Q A;  2RE3 A;  1WMV A;  2JV4 A;  1F8A B;  2E45 A;  3TDB A;  2LAJ A;  3NTP A;  2ZR4 A;  2DK1 A;  1WR7 A;  2ZQV A;  2L4J A;  1YW5 A; 
#chains in the Genus database with same CATH topology
 2M8I A;  2YSH A;  2ZQU A;  5CQ2 A;  5E5W A;  2WAD A;  2XP9 A;  2ZQT A;  4U85 A;  2EZ5 W;  2XP3 A;  2KXQ A;  2Y8N B;  2ZR5 A;  2M8J A;  2JXW A;  2BA1 A;  3CNG A;  4U84 A;  3KAF A;  2WAE A;  3FSB A;  2YSI A;  3LKX A;  5AHT A;  2DJY A;  3KCE A;  1PIN A;  1I5H W;  2YAJ B;  1FLC A;  3LE4 A;  2XP5 A;  2YSF A;  2ZQS A;  1RP5 A;  2ZR6 A;  5E64 A;  2XPA A;  2QRV A;  2Q5A A;  2XP4 A;  4U86 A;  3KAH A;  4A0U A;  1JMQ A;  3LKX B;  4E5R A;  1K9R A;  3KAB A;  3KAG A;  2XP7 A;  2JMF A;  3KAI A;  2ITK A;  5E66 A;  2M3O W;  1TK7 A;  2XPB A;  1NMV A;  4REX A;  1O6W A;  5E62 A;  1EG4 A;  4A0T A;  3WH0 A;  2XP8 A;  1ZCN A;  3M7N A;  1EG3 A;  3PQH A;  2DWV A;  2YSB A;  3ODK A;  2DMV A;  2JX8 A;  2YSG A;  2XP6 A;  2MDI A;  5U47 A;  2F21 A;  3MCB A;  3OOB A;  3TC5 A;  2ZAJ A;  3TCZ A;  3MQG A;  2DK7 A;  2OWO A;  3L4H A;  4QIB A;  5E65 A;  1TR8 A;  3FSC A;  3KAD A;  3M85 A;  1K9Q A;  2RE3 A;  1WMV A;  2JV4 A;  1F8A B;  2E45 A;  3MQH A;  3TDB A;  2LAJ A;  3NTP A;  2ZR4 A;  3MCB B;  2DK1 A;  4GLX A;  1WR7 A;  2ZQV A;  3FS8 A;  2L4J A;  1YW5 A; 
#chains in the Genus database with same CATH homology
 2M8I A;  2YSH A;  2ZQU A;  5CQ2 A;  5E5W A;  2WAD A;  2XP9 A;  2ZQT A;  4U85 A;  2EZ5 W;  2XP3 A;  2KXQ A;  2Y8N B;  2ZR5 A;  2M8J A;  2JXW A;  2BA1 A;  3CNG A;  4U84 A;  3KAF A;  2WAE A;  3FSB A;  2YSI A;  3LKX A;  5AHT A;  2DJY A;  3KCE A;  1PIN A;  1I5H W;  2YAJ B;  1FLC A;  3LE4 A;  2XP5 A;  2YSF A;  2ZQS A;  1RP5 A;  2ZR6 A;  5E64 A;  2XPA A;  2QRV A;  2Q5A A;  2XP4 A;  4U86 A;  3KAH A;  4A0U A;  1JMQ A;  3LKX B;  4E5R A;  1K9R A;  3KAB A;  3KAG A;  2XP7 A;  2JMF A;  3KAI A;  2ITK A;  5E66 A;  2M3O W;  1TK7 A;  2XPB A;  1NMV A;  4REX A;  1O6W A;  5E62 A;  1EG4 A;  4A0T A;  3WH0 A;  2XP8 A;  1ZCN A;  3M7N A;  1EG3 A;  3PQH A;  2DWV A;  2YSB A;  3ODK A;  2DMV A;  2JX8 A;  2YSG A;  2XP6 A;  2MDI A;  5U47 A;  2F21 A;  3MCB A;  3OOB A;  3TC5 A;  2ZAJ A;  3TCZ A;  3MQG A;  2DK7 A;  2OWO A;  3L4H A;  4QIB A;  5E65 A;  1TR8 A;  3FSC A;  3KAD A;  3M85 A;  1K9Q A;  2RE3 A;  1WMV A;  2JV4 A;  1F8A B;  2E45 A;  3MQH A;  3TDB A;  2LAJ A;  3NTP A;  2ZR4 A;  3MCB B;  2DK1 A;  4GLX A;  1WR7 A;  2ZQV A;  3FS8 A;  2L4J A;  1YW5 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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