2DMVA

Solution structure of the second ww domain of itchy homolog e3 ubiquitin protein ligase (itch)
Total Genus 3
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
3
sequence length
43
structure length
43
Chain Sequence
GSSGSSGLPPGWEQRVDQHGRVYYVDHVEKRTTWDRPSGPSSG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Solution structure of the second ww domain of Itchy homolog E3 ubiquitin protein ligase (Itch)
rcsb
molecule tags Ligase
source organism Homo sapiens
molecule keywords Itchy homolog E3 ubiquitin protein ligase
total genus 3
structure length 43
sequence length 43
ec nomenclature ec 2.3.2.26: HECT-type E3 ubiquitin transferase.
pdb deposition date 2006-04-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00397 WW WW domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.20.70.10 Mainly Beta Single Sheet Ubiquitin Ligase Nedd4; Chain: W; Ubiquitin Ligase Nedd4; Chain: W; 2dmvA01
2YSFA 3KAIA 2XPAA 1F8AB 3M85A 3TC5A 2XP9A 3L4HA 2ZQSA 2DMVA 2JX8A 2M8IA 2ZR5A 2F21A 5CQ2A 3KADA 1K9RA 1O6WA 2YSBA 2DJYA 2M3OW 2ZR4A 2EZ5W 2RE3A 2ITKA 1JMQA 2XP6A 1I5HW 2KXQA 2ZAJA 2M8JA 3KABA 3KAHA 3LE4A 1NMVA 3OOBA 4U84A 2XP8A 1WMVA 2JMFA 1ZCNA 3KAFA 2XP4A 2JXWA 3M7NA 2ZQUA 2XP5A 4U85A 2XP3A 2YSHA 1EG4A 2Q5AA 2XP7A 2DK1A 2BA1A 4REXA 4E5RA 2LAJA 5AHTA 2E45A 1YW5A 2ZQVA 1WR7A 4U86A 2YSGA 3NTPA 2ZQTA 3KCEA 2YSIA 1PINA 2DK7A 2DWVA 3ODKA 2XPBA 4QIBA 3CNGA 3TCZA 1K9QA 2L4JA 3WH0A 3TDBA 1EG3A 1TK7A 3KAGA 2MDIA 2ZR6A 2JV4A
chains in the Genus database with same CATH superfamily
2YSFA 3KAIA 4A0TA 5E65A 5E62A 3MQHA 2XPAA 1F8AB 3LKXA 5E64A 4GLXA 3MCBA 2WADA 5E5WA 3M85A 3TC5A 2XP9A 3L4HA 2ZQSA 2DMVA 3MQGA 3PQHA 1FLCA 2JX8A 2M8IA 2ZR5A 2F21A 5E66A 5CQ2A 3KADA 1K9RA 1O6WA 2YSBA 2DJYA 2M3OW 2ZR4A 2EZ5W 2RE3A 2ITKA 1JMQA 2XP6A 2WAEA 1I5HW 2KXQA 2ZAJA 2M8JA 3KABA 3KAHA 1RP5A 3LE4A 1NMVA 3OOBA 4U84A 2XP8A 1WMVA 2JMFA 1ZCNA 3KAFA 3FSCA 4A0UA 2YAJB 2XP4A 2JXWA 3M7NA 2ZQUA 2XP5A 4U85A 2QRVA 2XP3A 2YSHA 1EG4A 2Q5AA 2XP7A 2DK1A 2BA1A 4REXA 3FSBA 4E5RA 2OWOA 2LAJA 5AHTA 2E45A 1YW5A 2ZQVA 3LKXB 1WR7A 4U86A 2YSGA 3NTPA 2ZQTA 3KCEA 2YSIA 5U47A 1PINA 2DK7A 2Y8NB 2DWVA 3ODKA 2XPBA 4QIBA 3CNGA 3TCZA 1K9QA 2L4JA 3WH0A 3TDBA 1EG3A 1TK7A 3MCBB 3KAGA 1TR8A 2MDIA 2ZR6A 3FS8A 2JV4A
chains in the Genus database with same CATH topology
2YSFA 3KAIA 4A0TA 5E65A 5E62A 3MQHA 2XPAA 1F8AB 3LKXA 5E64A 4GLXA 3MCBA 2WADA 5E5WA 3M85A 3TC5A 2XP9A 3L4HA 2ZQSA 2DMVA 3MQGA 3PQHA 1FLCA 2JX8A 2M8IA 2ZR5A 2F21A 5E66A 5CQ2A 3KADA 1K9RA 1O6WA 2YSBA 2DJYA 2M3OW 2ZR4A 2EZ5W 2RE3A 2ITKA 1JMQA 2XP6A 2WAEA 1I5HW 2KXQA 2ZAJA 2M8JA 3KABA 3KAHA 1RP5A 3LE4A 1NMVA 3OOBA 4U84A 2XP8A 1WMVA 2JMFA 1ZCNA 3KAFA 3FSCA 4A0UA 2YAJB 2XP4A 2JXWA 3M7NA 2ZQUA 2XP5A 4U85A 2QRVA 2XP3A 2YSHA 1EG4A 2Q5AA 2XP7A 2DK1A 2BA1A 4REXA 3FSBA 4E5RA 2OWOA 2LAJA 5AHTA 2E45A 1YW5A 2ZQVA 3LKXB 1WR7A 4U86A 2YSGA 3NTPA 2ZQTA 3KCEA 2YSIA 5U47A 1PINA 2DK7A 2Y8NB 2DWVA 3ODKA 2XPBA 4QIBA 3CNGA 3TCZA 1K9QA 2L4JA 3WH0A 3TDBA 1EG3A 1TK7A 3MCBB 3KAGA 1TR8A 2MDIA 2ZR6A 3FS8A 2JV4A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2YSF A;  3KAI A;  2XPA A;  1F8A B;  3M85 A;  3TC5 A;  2XP9 A;  3L4H A;  2ZQS A;  2DMV A;  2JX8 A;  2M8I A;  2ZR5 A;  2F21 A;  5CQ2 A;  3KAD A;  1K9R A;  1O6W A;  2YSB A;  2DJY A;  2M3O W;  2ZR4 A;  2EZ5 W;  2RE3 A;  2ITK A;  1JMQ A;  2XP6 A;  1I5H W;  2KXQ A;  2ZAJ A;  2M8J A;  3KAB A;  3KAH A;  3LE4 A;  1NMV A;  3OOB A;  4U84 A;  2XP8 A;  1WMV A;  2JMF A;  1ZCN A;  3KAF A;  2XP4 A;  2JXW A;  3M7N A;  2ZQU A;  2XP5 A;  4U85 A;  2XP3 A;  2YSH A;  1EG4 A;  2Q5A A;  2XP7 A;  2DK1 A;  2BA1 A;  4REX A;  4E5R A;  2LAJ A;  5AHT A;  2E45 A;  1YW5 A;  2ZQV A;  1WR7 A;  4U86 A;  2YSG A;  3NTP A;  2ZQT A;  3KCE A;  2YSI A;  1PIN A;  2DK7 A;  2DWV A;  3ODK A;  2XPB A;  4QIB A;  3CNG A;  3TCZ A;  1K9Q A;  2L4J A;  3WH0 A;  3TDB A;  1EG3 A;  1TK7 A;  3KAG A;  2MDI A;  2ZR6 A;  2JV4 A; 
#chains in the Genus database with same CATH topology
 2YSF A;  3KAI A;  4A0T A;  5E65 A;  5E62 A;  3MQH A;  2XPA A;  1F8A B;  3LKX A;  5E64 A;  4GLX A;  3MCB A;  2WAD A;  5E5W A;  3M85 A;  3TC5 A;  2XP9 A;  3L4H A;  2ZQS A;  2DMV A;  3MQG A;  3PQH A;  1FLC A;  2JX8 A;  2M8I A;  2ZR5 A;  2F21 A;  5E66 A;  5CQ2 A;  3KAD A;  1K9R A;  1O6W A;  2YSB A;  2DJY A;  2M3O W;  2ZR4 A;  2EZ5 W;  2RE3 A;  2ITK A;  1JMQ A;  2XP6 A;  2WAE A;  1I5H W;  2KXQ A;  2ZAJ A;  2M8J A;  3KAB A;  3KAH A;  1RP5 A;  3LE4 A;  1NMV A;  3OOB A;  4U84 A;  2XP8 A;  1WMV A;  2JMF A;  1ZCN A;  3KAF A;  3FSC A;  4A0U A;  2YAJ B;  2XP4 A;  2JXW A;  3M7N A;  2ZQU A;  2XP5 A;  4U85 A;  2QRV A;  2XP3 A;  2YSH A;  1EG4 A;  2Q5A A;  2XP7 A;  2DK1 A;  2BA1 A;  4REX A;  3FSB A;  4E5R A;  2OWO A;  2LAJ A;  5AHT A;  2E45 A;  1YW5 A;  2ZQV A;  3LKX B;  1WR7 A;  4U86 A;  2YSG A;  3NTP A;  2ZQT A;  3KCE A;  2YSI A;  5U47 A;  1PIN A;  2DK7 A;  2Y8N B;  2DWV A;  3ODK A;  2XPB A;  4QIB A;  3CNG A;  3TCZ A;  1K9Q A;  2L4J A;  3WH0 A;  3TDB A;  1EG3 A;  1TK7 A;  3MCB B;  3KAG A;  1TR8 A;  2MDI A;  2ZR6 A;  3FS8 A;  2JV4 A; 
#chains in the Genus database with same CATH homology
 2YSF A;  3KAI A;  4A0T A;  5E65 A;  5E62 A;  3MQH A;  2XPA A;  1F8A B;  3LKX A;  5E64 A;  4GLX A;  3MCB A;  2WAD A;  5E5W A;  3M85 A;  3TC5 A;  2XP9 A;  3L4H A;  2ZQS A;  2DMV A;  3MQG A;  3PQH A;  1FLC A;  2JX8 A;  2M8I A;  2ZR5 A;  2F21 A;  5E66 A;  5CQ2 A;  3KAD A;  1K9R A;  1O6W A;  2YSB A;  2DJY A;  2M3O W;  2ZR4 A;  2EZ5 W;  2RE3 A;  2ITK A;  1JMQ A;  2XP6 A;  2WAE A;  1I5H W;  2KXQ A;  2ZAJ A;  2M8J A;  3KAB A;  3KAH A;  1RP5 A;  3LE4 A;  1NMV A;  3OOB A;  4U84 A;  2XP8 A;  1WMV A;  2JMF A;  1ZCN A;  3KAF A;  3FSC A;  4A0U A;  2YAJ B;  2XP4 A;  2JXW A;  3M7N A;  2ZQU A;  2XP5 A;  4U85 A;  2QRV A;  2XP3 A;  2YSH A;  1EG4 A;  2Q5A A;  2XP7 A;  2DK1 A;  2BA1 A;  4REX A;  3FSB A;  4E5R A;  2OWO A;  2LAJ A;  5AHT A;  2E45 A;  1YW5 A;  2ZQV A;  3LKX B;  1WR7 A;  4U86 A;  2YSG A;  3NTP A;  2ZQT A;  3KCE A;  2YSI A;  5U47 A;  1PIN A;  2DK7 A;  2Y8N B;  2DWV A;  3ODK A;  2XPB A;  4QIB A;  3CNG A;  3TCZ A;  1K9Q A;  2L4J A;  3WH0 A;  3TDB A;  1EG3 A;  1TK7 A;  3MCB B;  3KAG A;  1TR8 A;  2MDI A;  2ZR6 A;  3FS8 A;  2JV4 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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