2KXQA

Solution structure of smurf2 ww2 and ww3 bound to smad7 py motif containing peptide
Total Genus 9
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
9
sequence length
90
structure length
90
Chain Sequence
GPLGGSPPDLPEGYEQRTTQQGQVYFLHTQTGVSTWHDPRVPRDLSNINCEELGPLPPGWEIRNTATGRVYFVDHNNRTTQFTDPRLSAN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Coupling of tandem Smad ubiquitination regulatory factor (Smurf) WW domains modulates target specificity.
pubmed doi rcsb
molecule tags Protein binding
source organism Homo sapiens
molecule keywords E3 ubiquitin-protein ligase SMURF2
total genus 9
structure length 90
sequence length 90
ec nomenclature ec 2.3.2.26: HECT-type E3 ubiquitin transferase.
pdb deposition date 2010-05-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00397 WW WW domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.20.70.10 Mainly Beta Single Sheet Ubiquitin Ligase Nedd4; Chain: W; Ubiquitin Ligase Nedd4; Chain: W; 2kxqA01
2.20.70.10 Mainly Beta Single Sheet Ubiquitin Ligase Nedd4; Chain: W; Ubiquitin Ligase Nedd4; Chain: W; 2kxqA02
2ITKA 3KAFA 1JMQA 2YSGA 2ZR6A 2ZQTA 2M8JA 1I5HW 1PINA 2ZR5A 3KAIA 3KCEA 2YSBA 3M7NA 3OOBA 2Q5AA 4E5RA 2LAJA 3WH0A 2F21A 3KADA 3NTPA 4QIBA 2ZAJA 3KAGA 2ZQUA 2XPBA 2YSFA 3KAHA 3CNGA 2L4JA 2MDIA 2RE3A 2XPAA 4U85A 1NMVA 2DK7A 2ZQSA 2DWVA 2E45A 4REXA 2DK1A 3TDBA 2EZ5W 4U86A 5AHTA 2XP7A 5CQ2A 1TK7A 1F8AB 2YSIA 1ZCNA 2M8IA 1K9RA 1YW5A 2DJYA 3KABA 2JMFA 2XP8A 2XP9A 2XP3A 2YSHA 2ZQVA 2ZR4A 3ODKA 2M3OW 3M85A 2XP5A 2JXWA 3TC5A 1O6WA 2JV4A 3TCZA 2XP6A 1K9QA 3LE4A 1EG4A 2KXQA 2XP4A 1WR7A 2BA1A 2DMVA 2JX8A 1WMVA 1EG3A 4U84A 3L4HA
chains in the Genus database with same CATH superfamily
2ITKA 3KAFA 1JMQA 2YSGA 2YAJB 2ZR6A 2ZQTA 2M8JA 1I5HW 1PINA 2ZR5A 3KAIA 3KCEA 2YSBA 3FSCA 3M7NA 5E65A 1RP5A 3OOBA 5E62A 2Q5AA 5E5WA 4E5RA 2LAJA 3WH0A 2F21A 3KADA 3NTPA 3FSBA 2ZAJA 1FLCA 3MQHA 4QIBA 5E66A 3KAGA 2ZQUA 2XPBA 2YSFA 3KAHA 3CNGA 2L4JA 2Y8NB 4A0TA 2MDIA 2RE3A 2XPAA 3MQGA 4U85A 1NMVA 2OWOA 2DK7A 2ZQSA 2DWVA 2E45A 4U84A 4REXA 1TR8A 5U47A 2DK1A 3PQHA 3TDBA 2EZ5W 4U86A 5AHTA 2XP7A 3FS8A 5CQ2A 1TK7A 1F8AB 2YSIA 1ZCNA 2M8IA 1K9RA 1YW5A 2DJYA 3LKXA 3KABA 3LKXB 2JMFA 2XP8A 2XP9A 2XP3A 2YSHA 2ZQVA 4GLXA 2ZR4A 3ODKA 2M3OW 4A0UA 2XP5A 3M85A 2JXWA 3TC5A 1O6WA 2JV4A 3TCZA 2XP6A 1K9QA 3LE4A 3MCBA 2WAEA 1EG4A 3MCBB 2KXQA 5E64A 2XP4A 1WR7A 2BA1A 2DMVA 2JX8A 1WMVA 1EG3A 2WADA 2QRVA 3L4HA
chains in the Genus database with same CATH topology
2ITKA 3KAFA 1JMQA 2YSGA 2YAJB 2ZR6A 2ZQTA 2M8JA 1I5HW 1PINA 2ZR5A 3KAIA 3KCEA 2YSBA 3FSCA 3M7NA 5E65A 1RP5A 3OOBA 5E62A 2Q5AA 5E5WA 4E5RA 2LAJA 3WH0A 2F21A 3KADA 3NTPA 3FSBA 2ZAJA 1FLCA 3MQHA 4QIBA 5E66A 3KAGA 2ZQUA 2XPBA 2YSFA 3KAHA 3CNGA 2L4JA 2Y8NB 4A0TA 2MDIA 2RE3A 2XPAA 3MQGA 4U85A 1NMVA 2OWOA 2DK7A 2ZQSA 2DWVA 2E45A 4U84A 4REXA 1TR8A 5U47A 2DK1A 3PQHA 3TDBA 2EZ5W 4U86A 5AHTA 2XP7A 3FS8A 5CQ2A 1TK7A 1F8AB 2YSIA 1ZCNA 2M8IA 1K9RA 1YW5A 2DJYA 3LKXA 3KABA 3LKXB 2JMFA 2XP8A 2XP9A 2XP3A 2YSHA 2ZQVA 4GLXA 2ZR4A 3ODKA 2M3OW 4A0UA 2XP5A 3M85A 2JXWA 3TC5A 1O6WA 2JV4A 3TCZA 2XP6A 1K9QA 3LE4A 3MCBA 2WAEA 1EG4A 3MCBB 2KXQA 5E64A 2XP4A 1WR7A 2BA1A 2DMVA 2JX8A 1WMVA 1EG3A 2WADA 2QRVA 3L4HA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2ITK A;  3KAF A;  1JMQ A;  2YSG A;  2ZR6 A;  2ZQT A;  2M8J A;  1I5H W;  1PIN A;  2ZR5 A;  3KAI A;  3KCE A;  2YSB A;  3M7N A;  3OOB A;  2Q5A A;  4E5R A;  2LAJ A;  3WH0 A;  2F21 A;  3KAD A;  3NTP A;  4QIB A;  2ZAJ A;  3KAG A;  2ZQU A;  2XPB A;  2YSF A;  3KAH A;  3CNG A;  2L4J A;  2MDI A;  2RE3 A;  2XPA A;  4U85 A;  1NMV A;  2DK7 A;  2ZQS A;  2DWV A;  2E45 A;  4REX A;  2DK1 A;  3TDB A;  2EZ5 W;  4U86 A;  5AHT A;  2XP7 A;  5CQ2 A;  1TK7 A;  1F8A B;  2YSI A;  1ZCN A;  2M8I A;  1K9R A;  1YW5 A;  2DJY A;  3KAB A;  2JMF A;  2XP8 A;  2XP9 A;  2XP3 A;  2YSH A;  2ZQV A;  2ZR4 A;  3ODK A;  2M3O W;  3M85 A;  2XP5 A;  2JXW A;  3TC5 A;  1O6W A;  2JV4 A;  3TCZ A;  2XP6 A;  1K9Q A;  3LE4 A;  1EG4 A;  2KXQ A;  2XP4 A;  1WR7 A;  2BA1 A;  2DMV A;  2JX8 A;  1WMV A;  1EG3 A;  4U84 A;  3L4H A; 
#chains in the Genus database with same CATH topology
 2ITK A;  3KAF A;  1JMQ A;  2YSG A;  2YAJ B;  2ZR6 A;  2ZQT A;  2M8J A;  1I5H W;  1PIN A;  2ZR5 A;  3KAI A;  3KCE A;  2YSB A;  3FSC A;  3M7N A;  5E65 A;  1RP5 A;  3OOB A;  5E62 A;  2Q5A A;  5E5W A;  4E5R A;  2LAJ A;  3WH0 A;  2F21 A;  3KAD A;  3NTP A;  3FSB A;  2ZAJ A;  1FLC A;  3MQH A;  4QIB A;  5E66 A;  3KAG A;  2ZQU A;  2XPB A;  2YSF A;  3KAH A;  3CNG A;  2L4J A;  2Y8N B;  4A0T A;  2MDI A;  2RE3 A;  2XPA A;  3MQG A;  4U85 A;  1NMV A;  2OWO A;  2DK7 A;  2ZQS A;  2DWV A;  2E45 A;  4U84 A;  4REX A;  1TR8 A;  5U47 A;  2DK1 A;  3PQH A;  3TDB A;  2EZ5 W;  4U86 A;  5AHT A;  2XP7 A;  3FS8 A;  5CQ2 A;  1TK7 A;  1F8A B;  2YSI A;  1ZCN A;  2M8I A;  1K9R A;  1YW5 A;  2DJY A;  3LKX A;  3KAB A;  3LKX B;  2JMF A;  2XP8 A;  2XP9 A;  2XP3 A;  2YSH A;  2ZQV A;  4GLX A;  2ZR4 A;  3ODK A;  2M3O W;  4A0U A;  2XP5 A;  3M85 A;  2JXW A;  3TC5 A;  1O6W A;  2JV4 A;  3TCZ A;  2XP6 A;  1K9Q A;  3LE4 A;  3MCB A;  2WAE A;  1EG4 A;  3MCB B;  2KXQ A;  5E64 A;  2XP4 A;  1WR7 A;  2BA1 A;  2DMV A;  2JX8 A;  1WMV A;  1EG3 A;  2WAD A;  2QRV A;  3L4H A; 
#chains in the Genus database with same CATH homology
 2ITK A;  3KAF A;  1JMQ A;  2YSG A;  2YAJ B;  2ZR6 A;  2ZQT A;  2M8J A;  1I5H W;  1PIN A;  2ZR5 A;  3KAI A;  3KCE A;  2YSB A;  3FSC A;  3M7N A;  5E65 A;  1RP5 A;  3OOB A;  5E62 A;  2Q5A A;  5E5W A;  4E5R A;  2LAJ A;  3WH0 A;  2F21 A;  3KAD A;  3NTP A;  3FSB A;  2ZAJ A;  1FLC A;  3MQH A;  4QIB A;  5E66 A;  3KAG A;  2ZQU A;  2XPB A;  2YSF A;  3KAH A;  3CNG A;  2L4J A;  2Y8N B;  4A0T A;  2MDI A;  2RE3 A;  2XPA A;  3MQG A;  4U85 A;  1NMV A;  2OWO A;  2DK7 A;  2ZQS A;  2DWV A;  2E45 A;  4U84 A;  4REX A;  1TR8 A;  5U47 A;  2DK1 A;  3PQH A;  3TDB A;  2EZ5 W;  4U86 A;  5AHT A;  2XP7 A;  3FS8 A;  5CQ2 A;  1TK7 A;  1F8A B;  2YSI A;  1ZCN A;  2M8I A;  1K9R A;  1YW5 A;  2DJY A;  3LKX A;  3KAB A;  3LKX B;  2JMF A;  2XP8 A;  2XP9 A;  2XP3 A;  2YSH A;  2ZQV A;  4GLX A;  2ZR4 A;  3ODK A;  2M3O W;  4A0U A;  2XP5 A;  3M85 A;  2JXW A;  3TC5 A;  1O6W A;  2JV4 A;  3TCZ A;  2XP6 A;  1K9Q A;  3LE4 A;  3MCB A;  2WAE A;  1EG4 A;  3MCB B;  2KXQ A;  5E64 A;  2XP4 A;  1WR7 A;  2BA1 A;  2DMV A;  2JX8 A;  1WMV A;  1EG3 A;  2WAD A;  2QRV A;  3L4H A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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