2M8IA

Structure of pin1 ww domain
Total Genus 3
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
3
sequence length
43
structure length
43
Chain Sequence
GLEHMADEEKLPPGWEKRMSRSSGRVYYFNHITNASQWERPSG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Molecular crowding drives active Pin1 into nonspecific complexes with endogenous proteins prior to substrate recognition.
pubmed doi rcsb
molecule tags Isomerase
source organism Homo sapiens
molecule keywords Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
total genus 3
structure length 43
sequence length 43
ec nomenclature ec 5.2.1.8: Peptidylprolyl isomerase.
pdb deposition date 2013-05-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00397 WW WW domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.20.70.10 Mainly Beta Single Sheet Ubiquitin Ligase Nedd4; Chain: W; Ubiquitin Ligase Nedd4; Chain: W; 2m8iA01
2JXWA 1EG3A 2LAJA 2JX8A 2F21A 1O6WA 2ZR4A 2XPBA 2ZR5A 2XP9A 2RE3A 1JMQA 2E45A 2XP3A 2DJYA 3KAHA 2XP6A 4REXA 2YSIA 3NTPA 2ITKA 3L4HA 3M85A 4E5RA 4QIBA 3M7NA 3KAIA 2BA1A 2DWVA 2L4JA 3TC5A 3KABA 2DK7A 3KAGA 4U85A 1WMVA 2DMVA 2XPAA 3TDBA 1PINA 1NMVA 2XP5A 2ZQTA 5CQ2A 1K9QA 2XP8A 1K9RA 1ZCNA 2JV4A 2ZQUA 2KXQA 2ZQVA 3WH0A 2M8JA 1WR7A 1EG4A 3KADA 4U84A 1I5HW 3ODKA 1F8AB 2EZ5W 2YSGA 2DK1A 1TK7A 2YSHA 2Q5AA 2M3OW 3KAFA 5AHTA 4U86A 2ZAJA 2YSFA 2MDIA 2ZQSA 2M8IA 3CNGA 2ZR6A 2JMFA 2XP4A 3KCEA 3LE4A 3TCZA 3OOBA 2YSBA 2XP7A 1YW5A
chains in the Genus database with same CATH superfamily
2JXWA 1EG3A 2LAJA 3MQHA 2JX8A 2F21A 1O6WA 2ZR4A 5E62A 2XPBA 2ZR5A 3MQGA 3FS8A 1TR8A 2XP9A 2RE3A 5E66A 1JMQA 2E45A 2XP3A 2DJYA 3KAHA 1RP5A 3MCBA 3FSBA 2XP6A 4REXA 2YSIA 3NTPA 2ITKA 3L4HA 3M85A 3PQHA 2Y8NB 5E65A 4E5RA 4QIBA 3M7NA 2WAEA 3KAIA 5E64A 2BA1A 2DWVA 2L4JA 3TC5A 3KABA 2DK7A 3KAGA 4U85A 1WMVA 2YAJB 2DMVA 2XPAA 3TDBA 1PINA 1NMVA 2XP5A 3LKXA 2ZQTA 5CQ2A 1K9QA 2XP8A 1K9RA 3MCBB 4A0TA 2WADA 1ZCNA 2JV4A 2ZQUA 2KXQA 2ZQVA 3WH0A 2M8JA 1WR7A 5U47A 1EG4A 3KADA 4U84A 4GLXA 1I5HW 3ODKA 1F8AB 2EZ5W 2YSGA 2DK1A 1TK7A 4A0UA 2YSHA 2Q5AA 2M3OW 3KAFA 5AHTA 4U86A 2ZAJA 2QRVA 2OWOA 2YSFA 2MDIA 2ZQSA 1FLCA 2M8IA 3CNGA 2ZR6A 3FSCA 2JMFA 2XP4A 3KCEA 3LE4A 3LKXB 5E5WA 3TCZA 3OOBA 2YSBA 2XP7A 1YW5A
chains in the Genus database with same CATH topology
2JXWA 1EG3A 2LAJA 3MQHA 2JX8A 2F21A 1O6WA 2ZR4A 5E62A 2XPBA 2ZR5A 3MQGA 3FS8A 1TR8A 2XP9A 2RE3A 5E66A 1JMQA 2E45A 2XP3A 2DJYA 3KAHA 1RP5A 3MCBA 3FSBA 2XP6A 4REXA 2YSIA 3NTPA 2ITKA 3L4HA 3M85A 3PQHA 2Y8NB 5E65A 4E5RA 4QIBA 3M7NA 2WAEA 3KAIA 5E64A 2BA1A 2DWVA 2L4JA 3TC5A 3KABA 2DK7A 3KAGA 4U85A 1WMVA 2YAJB 2DMVA 2XPAA 3TDBA 1PINA 1NMVA 2XP5A 3LKXA 2ZQTA 5CQ2A 1K9QA 2XP8A 1K9RA 3MCBB 4A0TA 2WADA 1ZCNA 2JV4A 2ZQUA 2KXQA 2ZQVA 3WH0A 2M8JA 1WR7A 5U47A 1EG4A 3KADA 4U84A 4GLXA 1I5HW 3ODKA 1F8AB 2EZ5W 2YSGA 2DK1A 1TK7A 4A0UA 2YSHA 2Q5AA 2M3OW 3KAFA 5AHTA 4U86A 2ZAJA 2QRVA 2OWOA 2YSFA 2MDIA 2ZQSA 1FLCA 2M8IA 3CNGA 2ZR6A 3FSCA 2JMFA 2XP4A 3KCEA 3LE4A 3LKXB 5E5WA 3TCZA 3OOBA 2YSBA 2XP7A 1YW5A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2JXW A;  1EG3 A;  2LAJ A;  2JX8 A;  2F21 A;  1O6W A;  2ZR4 A;  2XPB A;  2ZR5 A;  2XP9 A;  2RE3 A;  1JMQ A;  2E45 A;  2XP3 A;  2DJY A;  3KAH A;  2XP6 A;  4REX A;  2YSI A;  3NTP A;  2ITK A;  3L4H A;  3M85 A;  4E5R A;  4QIB A;  3M7N A;  3KAI A;  2BA1 A;  2DWV A;  2L4J A;  3TC5 A;  3KAB A;  2DK7 A;  3KAG A;  4U85 A;  1WMV A;  2DMV A;  2XPA A;  3TDB A;  1PIN A;  1NMV A;  2XP5 A;  2ZQT A;  5CQ2 A;  1K9Q A;  2XP8 A;  1K9R A;  1ZCN A;  2JV4 A;  2ZQU A;  2KXQ A;  2ZQV A;  3WH0 A;  2M8J A;  1WR7 A;  1EG4 A;  3KAD A;  4U84 A;  1I5H W;  3ODK A;  1F8A B;  2EZ5 W;  2YSG A;  2DK1 A;  1TK7 A;  2YSH A;  2Q5A A;  2M3O W;  3KAF A;  5AHT A;  4U86 A;  2ZAJ A;  2YSF A;  2MDI A;  2ZQS A;  2M8I A;  3CNG A;  2ZR6 A;  2JMF A;  2XP4 A;  3KCE A;  3LE4 A;  3TCZ A;  3OOB A;  2YSB A;  2XP7 A;  1YW5 A; 
#chains in the Genus database with same CATH topology
 2JXW A;  1EG3 A;  2LAJ A;  3MQH A;  2JX8 A;  2F21 A;  1O6W A;  2ZR4 A;  5E62 A;  2XPB A;  2ZR5 A;  3MQG A;  3FS8 A;  1TR8 A;  2XP9 A;  2RE3 A;  5E66 A;  1JMQ A;  2E45 A;  2XP3 A;  2DJY A;  3KAH A;  1RP5 A;  3MCB A;  3FSB A;  2XP6 A;  4REX A;  2YSI A;  3NTP A;  2ITK A;  3L4H A;  3M85 A;  3PQH A;  2Y8N B;  5E65 A;  4E5R A;  4QIB A;  3M7N A;  2WAE A;  3KAI A;  5E64 A;  2BA1 A;  2DWV A;  2L4J A;  3TC5 A;  3KAB A;  2DK7 A;  3KAG A;  4U85 A;  1WMV A;  2YAJ B;  2DMV A;  2XPA A;  3TDB A;  1PIN A;  1NMV A;  2XP5 A;  3LKX A;  2ZQT A;  5CQ2 A;  1K9Q A;  2XP8 A;  1K9R A;  3MCB B;  4A0T A;  2WAD A;  1ZCN A;  2JV4 A;  2ZQU A;  2KXQ A;  2ZQV A;  3WH0 A;  2M8J A;  1WR7 A;  5U47 A;  1EG4 A;  3KAD A;  4U84 A;  4GLX A;  1I5H W;  3ODK A;  1F8A B;  2EZ5 W;  2YSG A;  2DK1 A;  1TK7 A;  4A0U A;  2YSH A;  2Q5A A;  2M3O W;  3KAF A;  5AHT A;  4U86 A;  2ZAJ A;  2QRV A;  2OWO A;  2YSF A;  2MDI A;  2ZQS A;  1FLC A;  2M8I A;  3CNG A;  2ZR6 A;  3FSC A;  2JMF A;  2XP4 A;  3KCE A;  3LE4 A;  3LKX B;  5E5W A;  3TCZ A;  3OOB A;  2YSB A;  2XP7 A;  1YW5 A; 
#chains in the Genus database with same CATH homology
 2JXW A;  1EG3 A;  2LAJ A;  3MQH A;  2JX8 A;  2F21 A;  1O6W A;  2ZR4 A;  5E62 A;  2XPB A;  2ZR5 A;  3MQG A;  3FS8 A;  1TR8 A;  2XP9 A;  2RE3 A;  5E66 A;  1JMQ A;  2E45 A;  2XP3 A;  2DJY A;  3KAH A;  1RP5 A;  3MCB A;  3FSB A;  2XP6 A;  4REX A;  2YSI A;  3NTP A;  2ITK A;  3L4H A;  3M85 A;  3PQH A;  2Y8N B;  5E65 A;  4E5R A;  4QIB A;  3M7N A;  2WAE A;  3KAI A;  5E64 A;  2BA1 A;  2DWV A;  2L4J A;  3TC5 A;  3KAB A;  2DK7 A;  3KAG A;  4U85 A;  1WMV A;  2YAJ B;  2DMV A;  2XPA A;  3TDB A;  1PIN A;  1NMV A;  2XP5 A;  3LKX A;  2ZQT A;  5CQ2 A;  1K9Q A;  2XP8 A;  1K9R A;  3MCB B;  4A0T A;  2WAD A;  1ZCN A;  2JV4 A;  2ZQU A;  2KXQ A;  2ZQV A;  3WH0 A;  2M8J A;  1WR7 A;  5U47 A;  1EG4 A;  3KAD A;  4U84 A;  4GLX A;  1I5H W;  3ODK A;  1F8A B;  2EZ5 W;  2YSG A;  2DK1 A;  1TK7 A;  4A0U A;  2YSH A;  2Q5A A;  2M3O W;  3KAF A;  5AHT A;  4U86 A;  2ZAJ A;  2QRV A;  2OWO A;  2YSF A;  2MDI A;  2ZQS A;  1FLC A;  2M8I A;  3CNG A;  2ZR6 A;  3FSC A;  2JMF A;  2XP4 A;  3KCE A;  3LE4 A;  3LKX B;  5E5W A;  3TCZ A;  3OOB A;  2YSB A;  2XP7 A;  1YW5 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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