3L4HA

Helical box domain and second ww domain of the human e3 ubiquitin-protein ligase hecw1
Total Genus 27
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
27
sequence length
109
structure length
109
Chain Sequence
LLLQSPAVKFITNPEFFTVLHANYSAYRVFTSSTCLKHMILKVRRDARNFERYQHNRDLVNFINMFADTRLELPRGWEIKTDQQGKSFFVDHNSRATTFIDPRIPLQNG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Protein binding
source organism Homo sapiens
publication title The tandem helical box and second WW domains of human HECW1
rcsb
molecule keywords E3 ubiquitin-protein ligase HECW1
total genus 27
structure length 109
sequence length 109
ec nomenclature ec 2.3.2.26: HECT-type E3 ubiquitin transferase.
pdb deposition date 2009-12-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF18436 HECW1_helix Helical box domain of E3 ubiquitin-protein ligase HECW1
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.20.70.10 Mainly Beta Single Sheet Ubiquitin Ligase Nedd4; Chain: W; Ubiquitin Ligase Nedd4; Chain: W; 3l4hA01
2F21A 2ZR5A 2LAJA 1O6WA 2ZAJA 3TDBA 2XP5A 2YSFA 1I5HW 2XP9A 2XP6A 2DWVA 1EG4A 2DK1A 2DJYA 2KXQA 3KCEA 1JMQA 2ZQVA 2XP8A 2JXWA 3TC5A 2XP3A 3M7NA 2Q5AA 3KAGA 3KAIA 2XPAA 2M8JA 1WR7A 2RE3A 4U85A 3KAFA 2ZQSA 2JMFA 5AHTA 3KABA 2ITKA 2M3OW 2ZR4A 2YSIA 1WMVA 2DK7A 1K9QA 3CNGA 2EZ5W 4U86A 1K9RA 2XP7A 2ZR6A 2ZQUA 2MDIA 2DMVA 4REXA 3TCZA 1NMVA 3L4HA 2YSGA 2BA1A 2ZQTA 2L4JA 3KADA 2YSBA 4E5RA 2M8IA 3KAHA 1EG3A 1TK7A 3NTPA 4QIBA 1YW5A 4U84A 2JX8A 3OOBA 3WH0A 3ODKA 2YSHA 2E45A 1F8AB 3LE4A 2XPBA 1ZCNA 1PINA 2XP4A 5CQ2A 3M85A 2JV4A
chains in the Genus database with same CATH superfamily
2F21A 2ZR5A 3MQHA 3LKXB 2LAJA 1O6WA 2ZAJA 3TDBA 1FLCA 2XP5A 2YSFA 1I5HW 5E64A 2XP9A 4A0UA 2XP6A 4GLXA 2YAJB 2DWVA 1EG4A 2DK1A 2DJYA 2KXQA 3KCEA 1JMQA 2ZQVA 2XP8A 1TR8A 2JXWA 1RP5A 3TC5A 2XP3A 4A0TA 2OWOA 3M7NA 2Q5AA 3KAGA 2WADA 3FSCA 3KAIA 2XPAA 2M8JA 1WR7A 2QRVA 3LKXA 2RE3A 4U85A 5E65A 3PQHA 3KAFA 2ZQSA 2JMFA 5AHTA 3KABA 2ITKA 2M3OW 5E62A 2ZR4A 5E5WA 2YSIA 1WMVA 2DK7A 3MCBB 1K9QA 3CNGA 2EZ5W 4U86A 1K9RA 2XP7A 2ZR6A 2ZQUA 2MDIA 2DMVA 4REXA 3TCZA 1NMVA 3L4HA 2YSGA 2BA1A 2ZQTA 2L4JA 5E66A 3KADA 2YSBA 4E5RA 2M8IA 3KAHA 3FS8A 3FSBA 2Y8NB 1EG3A 1TK7A 3NTPA 4QIBA 1YW5A 4U84A 2JX8A 3MQGA 3OOBA 3WH0A 3ODKA 2YSHA 2E45A 1F8AB 3LE4A 2XPBA 1ZCNA 1PINA 2XP4A 5CQ2A 5U47A 2WAEA 3M85A 3MCBA 2JV4A
chains in the Genus database with same CATH topology
2F21A 2ZR5A 3MQHA 3LKXB 2LAJA 1O6WA 2ZAJA 3TDBA 1FLCA 2XP5A 2YSFA 1I5HW 5E64A 2XP9A 4A0UA 2XP6A 4GLXA 2YAJB 2DWVA 1EG4A 2DK1A 2DJYA 2KXQA 3KCEA 1JMQA 2ZQVA 2XP8A 1TR8A 2JXWA 1RP5A 3TC5A 2XP3A 4A0TA 2OWOA 3M7NA 2Q5AA 3KAGA 2WADA 3FSCA 3KAIA 2XPAA 2M8JA 1WR7A 2QRVA 3LKXA 2RE3A 4U85A 5E65A 3PQHA 3KAFA 2ZQSA 2JMFA 5AHTA 3KABA 2ITKA 2M3OW 5E62A 2ZR4A 5E5WA 2YSIA 1WMVA 2DK7A 3MCBB 1K9QA 3CNGA 2EZ5W 4U86A 1K9RA 2XP7A 2ZR6A 2ZQUA 2MDIA 2DMVA 4REXA 3TCZA 1NMVA 3L4HA 2YSGA 2BA1A 2ZQTA 2L4JA 5E66A 3KADA 2YSBA 4E5RA 2M8IA 3KAHA 3FS8A 3FSBA 2Y8NB 1EG3A 1TK7A 3NTPA 4QIBA 1YW5A 4U84A 2JX8A 3MQGA 3OOBA 3WH0A 3ODKA 2YSHA 2E45A 1F8AB 3LE4A 2XPBA 1ZCNA 1PINA 2XP4A 5CQ2A 5U47A 2WAEA 3M85A 3MCBA 2JV4A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2F21 A;  2ZR5 A;  2LAJ A;  1O6W A;  2ZAJ A;  3TDB A;  2XP5 A;  2YSF A;  1I5H W;  2XP9 A;  2XP6 A;  2DWV A;  1EG4 A;  2DK1 A;  2DJY A;  2KXQ A;  3KCE A;  1JMQ A;  2ZQV A;  2XP8 A;  2JXW A;  3TC5 A;  2XP3 A;  3M7N A;  2Q5A A;  3KAG A;  3KAI A;  2XPA A;  2M8J A;  1WR7 A;  2RE3 A;  4U85 A;  3KAF A;  2ZQS A;  2JMF A;  5AHT A;  3KAB A;  2ITK A;  2M3O W;  2ZR4 A;  2YSI A;  1WMV A;  2DK7 A;  1K9Q A;  3CNG A;  2EZ5 W;  4U86 A;  1K9R A;  2XP7 A;  2ZR6 A;  2ZQU A;  2MDI A;  2DMV A;  4REX A;  3TCZ A;  1NMV A;  3L4H A;  2YSG A;  2BA1 A;  2ZQT A;  2L4J A;  3KAD A;  2YSB A;  4E5R A;  2M8I A;  3KAH A;  1EG3 A;  1TK7 A;  3NTP A;  4QIB A;  1YW5 A;  4U84 A;  2JX8 A;  3OOB A;  3WH0 A;  3ODK A;  2YSH A;  2E45 A;  1F8A B;  3LE4 A;  2XPB A;  1ZCN A;  1PIN A;  2XP4 A;  5CQ2 A;  3M85 A;  2JV4 A; 
#chains in the Genus database with same CATH topology
 2F21 A;  2ZR5 A;  3MQH A;  3LKX B;  2LAJ A;  1O6W A;  2ZAJ A;  3TDB A;  1FLC A;  2XP5 A;  2YSF A;  1I5H W;  5E64 A;  2XP9 A;  4A0U A;  2XP6 A;  4GLX A;  2YAJ B;  2DWV A;  1EG4 A;  2DK1 A;  2DJY A;  2KXQ A;  3KCE A;  1JMQ A;  2ZQV A;  2XP8 A;  1TR8 A;  2JXW A;  1RP5 A;  3TC5 A;  2XP3 A;  4A0T A;  2OWO A;  3M7N A;  2Q5A A;  3KAG A;  2WAD A;  3FSC A;  3KAI A;  2XPA A;  2M8J A;  1WR7 A;  2QRV A;  3LKX A;  2RE3 A;  4U85 A;  5E65 A;  3PQH A;  3KAF A;  2ZQS A;  2JMF A;  5AHT A;  3KAB A;  2ITK A;  2M3O W;  5E62 A;  2ZR4 A;  5E5W A;  2YSI A;  1WMV A;  2DK7 A;  3MCB B;  1K9Q A;  3CNG A;  2EZ5 W;  4U86 A;  1K9R A;  2XP7 A;  2ZR6 A;  2ZQU A;  2MDI A;  2DMV A;  4REX A;  3TCZ A;  1NMV A;  3L4H A;  2YSG A;  2BA1 A;  2ZQT A;  2L4J A;  5E66 A;  3KAD A;  2YSB A;  4E5R A;  2M8I A;  3KAH A;  3FS8 A;  3FSB A;  2Y8N B;  1EG3 A;  1TK7 A;  3NTP A;  4QIB A;  1YW5 A;  4U84 A;  2JX8 A;  3MQG A;  3OOB A;  3WH0 A;  3ODK A;  2YSH A;  2E45 A;  1F8A B;  3LE4 A;  2XPB A;  1ZCN A;  1PIN A;  2XP4 A;  5CQ2 A;  5U47 A;  2WAE A;  3M85 A;  3MCB A;  2JV4 A; 
#chains in the Genus database with same CATH homology
 2F21 A;  2ZR5 A;  3MQH A;  3LKX B;  2LAJ A;  1O6W A;  2ZAJ A;  3TDB A;  1FLC A;  2XP5 A;  2YSF A;  1I5H W;  5E64 A;  2XP9 A;  4A0U A;  2XP6 A;  4GLX A;  2YAJ B;  2DWV A;  1EG4 A;  2DK1 A;  2DJY A;  2KXQ A;  3KCE A;  1JMQ A;  2ZQV A;  2XP8 A;  1TR8 A;  2JXW A;  1RP5 A;  3TC5 A;  2XP3 A;  4A0T A;  2OWO A;  3M7N A;  2Q5A A;  3KAG A;  2WAD A;  3FSC A;  3KAI A;  2XPA A;  2M8J A;  1WR7 A;  2QRV A;  3LKX A;  2RE3 A;  4U85 A;  5E65 A;  3PQH A;  3KAF A;  2ZQS A;  2JMF A;  5AHT A;  3KAB A;  2ITK A;  2M3O W;  5E62 A;  2ZR4 A;  5E5W A;  2YSI A;  1WMV A;  2DK7 A;  3MCB B;  1K9Q A;  3CNG A;  2EZ5 W;  4U86 A;  1K9R A;  2XP7 A;  2ZR6 A;  2ZQU A;  2MDI A;  2DMV A;  4REX A;  3TCZ A;  1NMV A;  3L4H A;  2YSG A;  2BA1 A;  2ZQT A;  2L4J A;  5E66 A;  3KAD A;  2YSB A;  4E5R A;  2M8I A;  3KAH A;  3FS8 A;  3FSB A;  2Y8N B;  1EG3 A;  1TK7 A;  3NTP A;  4QIB A;  1YW5 A;  4U84 A;  2JX8 A;  3MQG A;  3OOB A;  3WH0 A;  3ODK A;  2YSH A;  2E45 A;  1F8A B;  3LE4 A;  2XPB A;  1ZCN A;  1PIN A;  2XP4 A;  5CQ2 A;  5U47 A;  2WAE A;  3M85 A;  3MCB A;  2JV4 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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