3L4H | Genus

Total Genus 27

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	27
sequence length	109
structure length	109
Chain Sequence	LLLQSPAVKFITNPEFFTVLHANYSAYRVFTSSTCLKHMILKVRRDARNFERYQHNRDLVNFINMFADTRLELPRGWEIKTDQQGKSFFVDHNSRATTFIDPRIPLQNG

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

molecule tags	Protein binding
source organism	Homo sapiens
publication title	The tandem helical box and second WW domains of human HECW1 rcsb
molecule keywords	E3 ubiquitin-protein ligase HECW1
total genus	27
structure length	109
sequence length	109
ec nomenclature	ec 2.3.2.26: HECT-type E3 ubiquitin transferase.
pdb deposition date	2009-12-20

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF18436	HECW1_helix	Helical box domain of E3 ubiquitin-protein ligase HECW1

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
2.20.70.10	Mainly Beta	Single Sheet	Ubiquitin Ligase Nedd4; Chain: W;	Ubiquitin Ligase Nedd4; Chain: W;	3l4hA01

3KADA 2ZQSA 2F21A 4E5RA 3OOBA 3KABA 1EG3A 2M8JA 2BA1A 2ZR5A 2JMFA 4U84A 5AHTA 2DK7A 1K9RA 2YSBA 3KAHA 2MDIA 2EZ5W 2YSIA 3KAIA 2XPBA 2DMVA 2KXQA 1JMQA 2L4JA 1WR7A 1I5HW 5CQ2A 2RE3A 3L4HA 1TK7A 1YW5A 1O6WA 3CNGA 2XP7A 4QIBA 2ZQVA 2DJYA 2Q5AA 3TDBA 1WMVA 2YSGA 1NMVA 3M7NA 2ZAJA 2XP6A 2DWVA 3WH0A 3M85A 3TC5A 2JV4A 4U85A 2YSHA 1PINA 3KCEA 1ZCNA 2E45A 3ODKA 2ZQTA 2M8IA 2ZR4A 2ZR6A 3KAFA 2JXWA 4U86A 1EG4A 2XPAA 3NTPA 2JX8A 2XP3A 3LE4A 2ITKA 2XP4A 1K9QA 4REXA 1F8AB 2LAJA 2XP8A 2M3OW 3KAGA 2ZQUA 2XP5A 2XP9A 3TCZA 2DK1A 2YSFA
chains in the Genus database with same CATH superfamily

3KADA 2ZQSA 2F21A 3MCBA 4E5RA 3OOBA 3KABA 1EG3A 5E5WA 2M8JA 2BA1A 2ZR5A 2JMFA 3MQGA 4U84A 2WADA 5AHTA 2DK7A 1K9RA 2YSBA 3KAHA 2MDIA 2EZ5W 2YSIA 3KAIA 2YAJB 1TR8A 2XPBA 2DMVA 2KXQA 1JMQA 2L4JA 3LKXA 1WR7A 1I5HW 5CQ2A 2RE3A 3L4HA 1TK7A 1YW5A 1O6WA 3CNGA 2XP7A 4QIBA 5E64A 2ZQVA 2DJYA 2Q5AA 3PQHA 3LKXB 3TDBA 1WMVA 2YSGA 1NMVA 3M7NA 2ZAJA 2XP6A 2DWVA 3MQHA 3WH0A 3M85A 5E65A 3TC5A 2JV4A 4U85A 2YSHA 1PINA 3KCEA 3FSCA 1FLCA 1ZCNA 2WAEA 4GLXA 2E45A 3ODKA 2ZQTA 2M8IA 3FS8A 2ZR4A 2ZR6A 3KAFA 4A0TA 5U47A 2JXWA 4U86A 1EG4A 2XPAA 3NTPA 2JX8A 2XP3A 3LE4A 4A0UA 2ITKA 2QRVA 3FSBA 2XP4A 1K9QA 4REXA 1F8AB 3MCBB 2LAJA 2XP8A 2M3OW 3KAGA 2OWOA 1RP5A 2ZQUA 2XP5A 2XP9A 5E66A 3TCZA 2DK1A 2Y8NB 5E62A 2YSFA
chains in the Genus database with same CATH topology

#chains in the Genus database with same CATH superfamily
 3KAD A;  2ZQS A;  2F21 A;  4E5R A;  3OOB A;  3KAB A;  1EG3 A;  2M8J A;  2BA1 A;  2ZR5 A;  2JMF A;  4U84 A;  5AHT A;  2DK7 A;  1K9R A;  2YSB A;  3KAH A;  2MDI A;  2EZ5 W;  2YSI A;  3KAI A;  2XPB A;  2DMV A;  2KXQ A;  1JMQ A;  2L4J A;  1WR7 A;  1I5H W;  5CQ2 A;  2RE3 A;  3L4H A;  1TK7 A;  1YW5 A;  1O6W A;  3CNG A;  2XP7 A;  4QIB A;  2ZQV A;  2DJY A;  2Q5A A;  3TDB A;  1WMV A;  2YSG A;  1NMV A;  3M7N A;  2ZAJ A;  2XP6 A;  2DWV A;  3WH0 A;  3M85 A;  3TC5 A;  2JV4 A;  4U85 A;  2YSH A;  1PIN A;  3KCE A;  1ZCN A;  2E45 A;  3ODK A;  2ZQT A;  2M8I A;  2ZR4 A;  2ZR6 A;  3KAF A;  2JXW A;  4U86 A;  1EG4 A;  2XPA A;  3NTP A;  2JX8 A;  2XP3 A;  3LE4 A;  2ITK A;  2XP4 A;  1K9Q A;  4REX A;  1F8A B;  2LAJ A;  2XP8 A;  2M3O W;  3KAG A;  2ZQU A;  2XP5 A;  2XP9 A;  3TCZ A;  2DK1 A;  2YSF A; 
#chains in the Genus database with same CATH topology
 3KAD A;  2ZQS A;  2F21 A;  3MCB A;  4E5R A;  3OOB A;  3KAB A;  1EG3 A;  5E5W A;  2M8J A;  2BA1 A;  2ZR5 A;  2JMF A;  3MQG A;  4U84 A;  2WAD A;  5AHT A;  2DK7 A;  1K9R A;  2YSB A;  3KAH A;  2MDI A;  2EZ5 W;  2YSI A;  3KAI A;  2YAJ B;  1TR8 A;  2XPB A;  2DMV A;  2KXQ A;  1JMQ A;  2L4J A;  3LKX A;  1WR7 A;  1I5H W;  5CQ2 A;  2RE3 A;  3L4H A;  1TK7 A;  1YW5 A;  1O6W A;  3CNG A;  2XP7 A;  4QIB A;  5E64 A;  2ZQV A;  2DJY A;  2Q5A A;  3PQH A;  3LKX B;  3TDB A;  1WMV A;  2YSG A;  1NMV A;  3M7N A;  2ZAJ A;  2XP6 A;  2DWV A;  3MQH A;  3WH0 A;  3M85 A;  5E65 A;  3TC5 A;  2JV4 A;  4U85 A;  2YSH A;  1PIN A;  3KCE A;  3FSC A;  1FLC A;  1ZCN A;  2WAE A;  4GLX A;  2E45 A;  3ODK A;  2ZQT A;  2M8I A;  3FS8 A;  2ZR4 A;  2ZR6 A;  3KAF A;  4A0T A;  5U47 A;  2JXW A;  4U86 A;  1EG4 A;  2XPA A;  3NTP A;  2JX8 A;  2XP3 A;  3LE4 A;  4A0U A;  2ITK A;  2QRV A;  3FSB A;  2XP4 A;  1K9Q A;  4REX A;  1F8A B;  3MCB B;  2LAJ A;  2XP8 A;  2M3O W;  3KAG A;  2OWO A;  1RP5 A;  2ZQU A;  2XP5 A;  2XP9 A;  5E66 A;  3TCZ A;  2DK1 A;  2Y8N B;  5E62 A;  2YSF A; 
#chains in the Genus database with same CATH homology
 3KAD A;  2ZQS A;  2F21 A;  3MCB A;  4E5R A;  3OOB A;  3KAB A;  1EG3 A;  5E5W A;  2M8J A;  2BA1 A;  2ZR5 A;  2JMF A;  3MQG A;  4U84 A;  2WAD A;  5AHT A;  2DK7 A;  1K9R A;  2YSB A;  3KAH A;  2MDI A;  2EZ5 W;  2YSI A;  3KAI A;  2YAJ B;  1TR8 A;  2XPB A;  2DMV A;  2KXQ A;  1JMQ A;  2L4J A;  3LKX A;  1WR7 A;  1I5H W;  5CQ2 A;  2RE3 A;  3L4H A;  1TK7 A;  1YW5 A;  1O6W A;  3CNG A;  2XP7 A;  4QIB A;  5E64 A;  2ZQV A;  2DJY A;  2Q5A A;  3PQH A;  3LKX B;  3TDB A;  1WMV A;  2YSG A;  1NMV A;  3M7N A;  2ZAJ A;  2XP6 A;  2DWV A;  3MQH A;  3WH0 A;  3M85 A;  5E65 A;  3TC5 A;  2JV4 A;  4U85 A;  2YSH A;  1PIN A;  3KCE A;  3FSC A;  1FLC A;  1ZCN A;  2WAE A;  4GLX A;  2E45 A;  3ODK A;  2ZQT A;  2M8I A;  3FS8 A;  2ZR4 A;  2ZR6 A;  3KAF A;  4A0T A;  5U47 A;  2JXW A;  4U86 A;  1EG4 A;  2XPA A;  3NTP A;  2JX8 A;  2XP3 A;  3LE4 A;  4A0U A;  2ITK A;  2QRV A;  3FSB A;  2XP4 A;  1K9Q A;  4REX A;  1F8A B;  3MCB B;  2LAJ A;  2XP8 A;  2M3O W;  3KAG A;  2OWO A;  1RP5 A;  2ZQU A;  2XP5 A;  2XP9 A;  5E66 A;  3TCZ A;  2DK1 A;  2Y8N B;  5E62 A;  2YSF A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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3L4HA

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

pfam database annotations