4REXA

Crystal structure of the first ww domain of human yap2 isoform
Total Genus 8
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
8
sequence length
48
structure length
48
Chain Sequence
GAMGFEIPDDVPLPAGWEMAKTSSGQRYFLNHIDQTTTWQDPRKAMLS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Crystal structure of the first WW domain of human YAP2 isoform.
pubmed doi rcsb
molecule tags Protein binding
source organism Homo sapiens
molecule keywords Yorkie homolog
total genus 8
structure length 48
sequence length 48
ec nomenclature
pdb deposition date 2014-09-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00397 WW WW domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.20.70.10 Mainly Beta Single Sheet Ubiquitin Ligase Nedd4; Chain: W; Ubiquitin Ligase Nedd4; Chain: W; 4rexA00
2XP6A 2L4JA 5AHTA 1YW5A 2DK1A 2ZAJA 2YSFA 5CQ2A 2Q5AA 2JXWA 2JX8A 2JV4A 1WR7A 2DJYA 2KXQA 1PINA 2ITKA 1K9RA 1EG3A 2BA1A 2XP3A 3TC5A 2ZR5A 1TK7A 2ZR6A 3M85A 3KAGA 3CNGA 3TDBA 3L4HA 3KCEA 2ZQVA 2RE3A 2YSGA 2E45A 3KAHA 3KAFA 1JMQA 2LAJA 3KADA 2F21A 2JMFA 3KAIA 1WMVA 3KABA 1NMVA 2M3OW 3WH0A 2XP9A 2XPBA 1EG4A 1O6WA 3ODKA 2DWVA 3M7NA 2XP7A 2EZ5W 3TCZA 1K9QA 2ZQUA 2ZQTA 1I5HW 4E5RA 2YSIA 2XP4A 4U86A 2YSBA 2M8IA 2DK7A 2XP5A 2ZQSA 4U85A 1F8AB 3LE4A 2XP8A 4QIBA 2XPAA 4U84A 2YSHA 2DMVA 1ZCNA 2M8JA 3OOBA 3NTPA 4REXA 2ZR4A 2MDIA
chains in the Genus database with same CATH superfamily
2XP6A 2L4JA 5AHTA 2YAJB 1YW5A 2DK1A 2ZAJA 2YSFA 5CQ2A 2Q5AA 2JXWA 5U47A 2JX8A 3LKXA 5E5WA 1RP5A 2JV4A 3PQHA 1WR7A 2DJYA 2KXQA 1PINA 2ITKA 1K9RA 1EG3A 1FLCA 3FS8A 2BA1A 2XP3A 3LKXB 3MQHA 3TC5A 2ZR5A 3MQGA 1TK7A 2ZR6A 3M85A 3KAGA 3CNGA 3FSBA 3TDBA 3L4HA 3KCEA 2ZQVA 2RE3A 2YSGA 2E45A 3KAHA 3KAFA 4GLXA 1JMQA 2LAJA 3KADA 2F21A 3MCBB 5E64A 2JMFA 3KAIA 2QRVA 1WMVA 3KABA 1NMVA 2M3OW 3WH0A 2XP9A 2XPBA 1EG4A 1O6WA 3MCBA 3ODKA 2DWVA 3M7NA 5E62A 2XP7A 2EZ5W 3TCZA 1K9QA 2ZQUA 2ZQTA 1I5HW 4E5RA 2YSIA 2OWOA 2XP4A 4U86A 2YSBA 2M8IA 2DK7A 2XP5A 2ZQSA 4U85A 1F8AB 3LE4A 2WADA 2Y8NB 3FSCA 2XP8A 4QIBA 2XPAA 4U84A 2YSHA 5E65A 2DMVA 1TR8A 1ZCNA 2M8JA 3OOBA 3NTPA 5E66A 4REXA 2ZR4A 4A0TA 2WAEA 4A0UA 2MDIA
chains in the Genus database with same CATH topology
2XP6A 2L4JA 5AHTA 2YAJB 1YW5A 2DK1A 2ZAJA 2YSFA 5CQ2A 2Q5AA 2JXWA 5U47A 2JX8A 3LKXA 5E5WA 1RP5A 2JV4A 3PQHA 1WR7A 2DJYA 2KXQA 1PINA 2ITKA 1K9RA 1EG3A 1FLCA 3FS8A 2BA1A 2XP3A 3LKXB 3MQHA 3TC5A 2ZR5A 3MQGA 1TK7A 2ZR6A 3M85A 3KAGA 3CNGA 3FSBA 3TDBA 3L4HA 3KCEA 2ZQVA 2RE3A 2YSGA 2E45A 3KAHA 3KAFA 4GLXA 1JMQA 2LAJA 3KADA 2F21A 3MCBB 5E64A 2JMFA 3KAIA 2QRVA 1WMVA 3KABA 1NMVA 2M3OW 3WH0A 2XP9A 2XPBA 1EG4A 1O6WA 3MCBA 3ODKA 2DWVA 3M7NA 5E62A 2XP7A 2EZ5W 3TCZA 1K9QA 2ZQUA 2ZQTA 1I5HW 4E5RA 2YSIA 2OWOA 2XP4A 4U86A 2YSBA 2M8IA 2DK7A 2XP5A 2ZQSA 4U85A 1F8AB 3LE4A 2WADA 2Y8NB 3FSCA 2XP8A 4QIBA 2XPAA 4U84A 2YSHA 5E65A 2DMVA 1TR8A 1ZCNA 2M8JA 3OOBA 3NTPA 5E66A 4REXA 2ZR4A 4A0TA 2WAEA 4A0UA 2MDIA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2XP6 A;  2L4J A;  5AHT A;  1YW5 A;  2DK1 A;  2ZAJ A;  2YSF A;  5CQ2 A;  2Q5A A;  2JXW A;  2JX8 A;  2JV4 A;  1WR7 A;  2DJY A;  2KXQ A;  1PIN A;  2ITK A;  1K9R A;  1EG3 A;  2BA1 A;  2XP3 A;  3TC5 A;  2ZR5 A;  1TK7 A;  2ZR6 A;  3M85 A;  3KAG A;  3CNG A;  3TDB A;  3L4H A;  3KCE A;  2ZQV A;  2RE3 A;  2YSG A;  2E45 A;  3KAH A;  3KAF A;  1JMQ A;  2LAJ A;  3KAD A;  2F21 A;  2JMF A;  3KAI A;  1WMV A;  3KAB A;  1NMV A;  2M3O W;  3WH0 A;  2XP9 A;  2XPB A;  1EG4 A;  1O6W A;  3ODK A;  2DWV A;  3M7N A;  2XP7 A;  2EZ5 W;  3TCZ A;  1K9Q A;  2ZQU A;  2ZQT A;  1I5H W;  4E5R A;  2YSI A;  2XP4 A;  4U86 A;  2YSB A;  2M8I A;  2DK7 A;  2XP5 A;  2ZQS A;  4U85 A;  1F8A B;  3LE4 A;  2XP8 A;  4QIB A;  2XPA A;  4U84 A;  2YSH A;  2DMV A;  1ZCN A;  2M8J A;  3OOB A;  3NTP A;  4REX A;  2ZR4 A;  2MDI A; 
#chains in the Genus database with same CATH topology
 2XP6 A;  2L4J A;  5AHT A;  2YAJ B;  1YW5 A;  2DK1 A;  2ZAJ A;  2YSF A;  5CQ2 A;  2Q5A A;  2JXW A;  5U47 A;  2JX8 A;  3LKX A;  5E5W A;  1RP5 A;  2JV4 A;  3PQH A;  1WR7 A;  2DJY A;  2KXQ A;  1PIN A;  2ITK A;  1K9R A;  1EG3 A;  1FLC A;  3FS8 A;  2BA1 A;  2XP3 A;  3LKX B;  3MQH A;  3TC5 A;  2ZR5 A;  3MQG A;  1TK7 A;  2ZR6 A;  3M85 A;  3KAG A;  3CNG A;  3FSB A;  3TDB A;  3L4H A;  3KCE A;  2ZQV A;  2RE3 A;  2YSG A;  2E45 A;  3KAH A;  3KAF A;  4GLX A;  1JMQ A;  2LAJ A;  3KAD A;  2F21 A;  3MCB B;  5E64 A;  2JMF A;  3KAI A;  2QRV A;  1WMV A;  3KAB A;  1NMV A;  2M3O W;  3WH0 A;  2XP9 A;  2XPB A;  1EG4 A;  1O6W A;  3MCB A;  3ODK A;  2DWV A;  3M7N A;  5E62 A;  2XP7 A;  2EZ5 W;  3TCZ A;  1K9Q A;  2ZQU A;  2ZQT A;  1I5H W;  4E5R A;  2YSI A;  2OWO A;  2XP4 A;  4U86 A;  2YSB A;  2M8I A;  2DK7 A;  2XP5 A;  2ZQS A;  4U85 A;  1F8A B;  3LE4 A;  2WAD A;  2Y8N B;  3FSC A;  2XP8 A;  4QIB A;  2XPA A;  4U84 A;  2YSH A;  5E65 A;  2DMV A;  1TR8 A;  1ZCN A;  2M8J A;  3OOB A;  3NTP A;  5E66 A;  4REX A;  2ZR4 A;  4A0T A;  2WAE A;  4A0U A;  2MDI A; 
#chains in the Genus database with same CATH homology
 2XP6 A;  2L4J A;  5AHT A;  2YAJ B;  1YW5 A;  2DK1 A;  2ZAJ A;  2YSF A;  5CQ2 A;  2Q5A A;  2JXW A;  5U47 A;  2JX8 A;  3LKX A;  5E5W A;  1RP5 A;  2JV4 A;  3PQH A;  1WR7 A;  2DJY A;  2KXQ A;  1PIN A;  2ITK A;  1K9R A;  1EG3 A;  1FLC A;  3FS8 A;  2BA1 A;  2XP3 A;  3LKX B;  3MQH A;  3TC5 A;  2ZR5 A;  3MQG A;  1TK7 A;  2ZR6 A;  3M85 A;  3KAG A;  3CNG A;  3FSB A;  3TDB A;  3L4H A;  3KCE A;  2ZQV A;  2RE3 A;  2YSG A;  2E45 A;  3KAH A;  3KAF A;  4GLX A;  1JMQ A;  2LAJ A;  3KAD A;  2F21 A;  3MCB B;  5E64 A;  2JMF A;  3KAI A;  2QRV A;  1WMV A;  3KAB A;  1NMV A;  2M3O W;  3WH0 A;  2XP9 A;  2XPB A;  1EG4 A;  1O6W A;  3MCB A;  3ODK A;  2DWV A;  3M7N A;  5E62 A;  2XP7 A;  2EZ5 W;  3TCZ A;  1K9Q A;  2ZQU A;  2ZQT A;  1I5H W;  4E5R A;  2YSI A;  2OWO A;  2XP4 A;  4U86 A;  2YSB A;  2M8I A;  2DK7 A;  2XP5 A;  2ZQS A;  4U85 A;  1F8A B;  3LE4 A;  2WAD A;  2Y8N B;  3FSC A;  2XP8 A;  4QIB A;  2XPA A;  4U84 A;  2YSH A;  5E65 A;  2DMV A;  1TR8 A;  1ZCN A;  2M8J A;  3OOB A;  3NTP A;  5E66 A;  4REX A;  2ZR4 A;  4A0T A;  2WAE A;  4A0U A;  2MDI A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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