5CQ2A

Crystal structure of tandem ww domains of itch in complex with txnip peptide
Total Genus 11
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
11
sequence length
80
structure length
76
Chain Sequence
GPLPPGWEKRTDSNGRVYFVNHNTRITQWEDPRSQEKPLPEGWEMRFTVDGIPYFVDHNRRTTTYIDPRTGKSALD
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural basis for the regulatory role of the PPxY motifs in the thioredoxin-interacting protein TXNIP.
pubmed doi rcsb
molecule keywords E3 ubiquitin-protein ligase Itchy homolog
molecule tags Ligase
source organism Homo sapiens
total genus 11
structure length 76
sequence length 80
ec nomenclature ec 2.3.2.26: HECT-type E3 ubiquitin transferase.
pdb deposition date 2015-07-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00397 WW WW domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.20.70.10 Mainly Beta Single Sheet Ubiquitin Ligase Nedd4; Chain: W; Ubiquitin Ligase Nedd4; Chain: W; 5cq2A02
2BA1A 1F8AB 4REXA 2M8IA 1YW5A 2DJYA 4QIBA 2EZ5W 2JXWA 5CQ2A 3NTPA 3LE4A 2XPBA 2KXQA 3TC5A 2L4JA 2DWVA 2RE3A 3KAGA 1K9QA 3TCZA 2E45A 3L4HA 2XP7A 2YSIA 2ZR6A 4U86A 2YSBA 1WMVA 2ITKA 1PINA 3OOBA 1EG3A 1K9RA 3M7NA 2ZR4A 2ZQTA 3M85A 2YSGA 2LAJA 2JV4A 2YSFA 2XP4A 1EG4A 2YSHA 2DMVA 2JMFA 1O6WA 3ODKA 3KCEA 2ZQVA 2F21A 3KAHA 2ZQSA 1TK7A 1I5HW 4E5RA 2XP6A 3KADA 3TDBA 4U85A 2MDIA 2DK1A 1JMQA 1NMVA 3CNGA 2ZR5A 2XPAA 2M8JA 2DK7A 2M3OW 2XP8A 3KAFA 2Q5AA 3WH0A 2JX8A 1WR7A 5AHTA 2XP9A 2ZQUA 2ZAJA 2XP5A 4U84A 2XP3A 3KAIA 1ZCNA 3KABA
chains in the Genus database with same CATH superfamily
1TR8A 2BA1A 3FS8A 2WAEA 1F8AB 3FSCA 4REXA 2M8IA 1YW5A 2DJYA 4QIBA 2EZ5W 2JXWA 5CQ2A 3NTPA 5E65A 3LE4A 2XPBA 2KXQA 3TC5A 5E62A 3MQGA 2L4JA 2DWVA 2RE3A 3KAGA 1K9QA 2WADA 5U47A 3TCZA 3LKXB 2E45A 3L4HA 2XP7A 2YSIA 2ZR6A 2Y8NB 4U86A 1RP5A 2YSBA 1WMVA 2ITKA 1PINA 3OOBA 1EG3A 1K9RA 3M7NA 3MQHA 2YAJB 2ZR4A 2ZQTA 3M85A 2YSGA 2LAJA 5E5WA 2JV4A 2YSFA 2XP4A 3FSBA 3MCBB 1EG4A 2YSHA 2DMVA 2QRVA 2JMFA 3PQHA 1O6WA 3ODKA 3LKXA 4A0UA 3KCEA 2ZQVA 2F21A 5E64A 3KAHA 2ZQSA 1TK7A 1I5HW 4E5RA 2XP6A 3KADA 5E66A 3TDBA 4U85A 2MDIA 2DK1A 1JMQA 1NMVA 1FLCA 3CNGA 2ZR5A 2XPAA 2M8JA 2DK7A 3MCBA 4GLXA 2M3OW 2XP8A 3KAFA 2OWOA 2Q5AA 3WH0A 2JX8A 1WR7A 4A0TA 5AHTA 2XP9A 2ZQUA 2ZAJA 2XP5A 4U84A 2XP3A 3KAIA 1ZCNA 3KABA
chains in the Genus database with same CATH topology
1TR8A 2BA1A 3FS8A 2WAEA 1F8AB 3FSCA 4REXA 2M8IA 1YW5A 2DJYA 4QIBA 2EZ5W 2JXWA 5CQ2A 3NTPA 5E65A 3LE4A 2XPBA 2KXQA 3TC5A 5E62A 3MQGA 2L4JA 2DWVA 2RE3A 3KAGA 1K9QA 2WADA 5U47A 3TCZA 3LKXB 2E45A 3L4HA 2XP7A 2YSIA 2ZR6A 2Y8NB 4U86A 1RP5A 2YSBA 1WMVA 2ITKA 1PINA 3OOBA 1EG3A 1K9RA 3M7NA 3MQHA 2YAJB 2ZR4A 2ZQTA 3M85A 2YSGA 2LAJA 5E5WA 2JV4A 2YSFA 2XP4A 3FSBA 3MCBB 1EG4A 2YSHA 2DMVA 2QRVA 2JMFA 3PQHA 1O6WA 3ODKA 3LKXA 4A0UA 3KCEA 2ZQVA 2F21A 5E64A 3KAHA 2ZQSA 1TK7A 1I5HW 4E5RA 2XP6A 3KADA 5E66A 3TDBA 4U85A 2MDIA 2DK1A 1JMQA 1NMVA 1FLCA 3CNGA 2ZR5A 2XPAA 2M8JA 2DK7A 3MCBA 4GLXA 2M3OW 2XP8A 3KAFA 2OWOA 2Q5AA 3WH0A 2JX8A 1WR7A 4A0TA 5AHTA 2XP9A 2ZQUA 2ZAJA 2XP5A 4U84A 2XP3A 3KAIA 1ZCNA 3KABA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2BA1 A;  1F8A B;  4REX A;  2M8I A;  1YW5 A;  2DJY A;  4QIB A;  2EZ5 W;  2JXW A;  5CQ2 A;  3NTP A;  3LE4 A;  2XPB A;  2KXQ A;  3TC5 A;  2L4J A;  2DWV A;  2RE3 A;  3KAG A;  1K9Q A;  3TCZ A;  2E45 A;  3L4H A;  2XP7 A;  2YSI A;  2ZR6 A;  4U86 A;  2YSB A;  1WMV A;  2ITK A;  1PIN A;  3OOB A;  1EG3 A;  1K9R A;  3M7N A;  2ZR4 A;  2ZQT A;  3M85 A;  2YSG A;  2LAJ A;  2JV4 A;  2YSF A;  2XP4 A;  1EG4 A;  2YSH A;  2DMV A;  2JMF A;  1O6W A;  3ODK A;  3KCE A;  2ZQV A;  2F21 A;  3KAH A;  2ZQS A;  1TK7 A;  1I5H W;  4E5R A;  2XP6 A;  3KAD A;  3TDB A;  4U85 A;  2MDI A;  2DK1 A;  1JMQ A;  1NMV A;  3CNG A;  2ZR5 A;  2XPA A;  2M8J A;  2DK7 A;  2M3O W;  2XP8 A;  3KAF A;  2Q5A A;  3WH0 A;  2JX8 A;  1WR7 A;  5AHT A;  2XP9 A;  2ZQU A;  2ZAJ A;  2XP5 A;  4U84 A;  2XP3 A;  3KAI A;  1ZCN A;  3KAB A; 
#chains in the Genus database with same CATH topology
 1TR8 A;  2BA1 A;  3FS8 A;  2WAE A;  1F8A B;  3FSC A;  4REX A;  2M8I A;  1YW5 A;  2DJY A;  4QIB A;  2EZ5 W;  2JXW A;  5CQ2 A;  3NTP A;  5E65 A;  3LE4 A;  2XPB A;  2KXQ A;  3TC5 A;  5E62 A;  3MQG A;  2L4J A;  2DWV A;  2RE3 A;  3KAG A;  1K9Q A;  2WAD A;  5U47 A;  3TCZ A;  3LKX B;  2E45 A;  3L4H A;  2XP7 A;  2YSI A;  2ZR6 A;  2Y8N B;  4U86 A;  1RP5 A;  2YSB A;  1WMV A;  2ITK A;  1PIN A;  3OOB A;  1EG3 A;  1K9R A;  3M7N A;  3MQH A;  2YAJ B;  2ZR4 A;  2ZQT A;  3M85 A;  2YSG A;  2LAJ A;  5E5W A;  2JV4 A;  2YSF A;  2XP4 A;  3FSB A;  3MCB B;  1EG4 A;  2YSH A;  2DMV A;  2QRV A;  2JMF A;  3PQH A;  1O6W A;  3ODK A;  3LKX A;  4A0U A;  3KCE A;  2ZQV A;  2F21 A;  5E64 A;  3KAH A;  2ZQS A;  1TK7 A;  1I5H W;  4E5R A;  2XP6 A;  3KAD A;  5E66 A;  3TDB A;  4U85 A;  2MDI A;  2DK1 A;  1JMQ A;  1NMV A;  1FLC A;  3CNG A;  2ZR5 A;  2XPA A;  2M8J A;  2DK7 A;  3MCB A;  4GLX A;  2M3O W;  2XP8 A;  3KAF A;  2OWO A;  2Q5A A;  3WH0 A;  2JX8 A;  1WR7 A;  4A0T A;  5AHT A;  2XP9 A;  2ZQU A;  2ZAJ A;  2XP5 A;  4U84 A;  2XP3 A;  3KAI A;  1ZCN A;  3KAB A; 
#chains in the Genus database with same CATH homology
 1TR8 A;  2BA1 A;  3FS8 A;  2WAE A;  1F8A B;  3FSC A;  4REX A;  2M8I A;  1YW5 A;  2DJY A;  4QIB A;  2EZ5 W;  2JXW A;  5CQ2 A;  3NTP A;  5E65 A;  3LE4 A;  2XPB A;  2KXQ A;  3TC5 A;  5E62 A;  3MQG A;  2L4J A;  2DWV A;  2RE3 A;  3KAG A;  1K9Q A;  2WAD A;  5U47 A;  3TCZ A;  3LKX B;  2E45 A;  3L4H A;  2XP7 A;  2YSI A;  2ZR6 A;  2Y8N B;  4U86 A;  1RP5 A;  2YSB A;  1WMV A;  2ITK A;  1PIN A;  3OOB A;  1EG3 A;  1K9R A;  3M7N A;  3MQH A;  2YAJ B;  2ZR4 A;  2ZQT A;  3M85 A;  2YSG A;  2LAJ A;  5E5W A;  2JV4 A;  2YSF A;  2XP4 A;  3FSB A;  3MCB B;  1EG4 A;  2YSH A;  2DMV A;  2QRV A;  2JMF A;  3PQH A;  1O6W A;  3ODK A;  3LKX A;  4A0U A;  3KCE A;  2ZQV A;  2F21 A;  5E64 A;  3KAH A;  2ZQS A;  1TK7 A;  1I5H W;  4E5R A;  2XP6 A;  3KAD A;  5E66 A;  3TDB A;  4U85 A;  2MDI A;  2DK1 A;  1JMQ A;  1NMV A;  1FLC A;  3CNG A;  2ZR5 A;  2XPA A;  2M8J A;  2DK7 A;  3MCB A;  4GLX A;  2M3O W;  2XP8 A;  3KAF A;  2OWO A;  2Q5A A;  3WH0 A;  2JX8 A;  1WR7 A;  4A0T A;  5AHT A;  2XP9 A;  2ZQU A;  2ZAJ A;  2XP5 A;  4U84 A;  2XP3 A;  3KAI A;  1ZCN A;  3KAB A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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