5CQ2A

Crystal structure of tandem ww domains of itch in complex with txnip peptide
Total Genus 11
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
11
sequence length
80
structure length
76
Chain Sequence
GPLPPGWEKRTDSNGRVYFVNHNTRITQWEDPRSQEKPLPEGWEMRFTVDGIPYFVDHNRRTTTYIDPRTGKSALD
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural basis for the regulatory role of the PPxY motifs in the thioredoxin-interacting protein TXNIP.
pubmed doi rcsb
molecule keywords E3 ubiquitin-protein ligase Itchy homolog
molecule tags Ligase
source organism Homo sapiens
total genus 11
structure length 76
sequence length 80
ec nomenclature ec 2.3.2.26: HECT-type E3 ubiquitin transferase.
pdb deposition date 2015-07-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00397 WW WW domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.20.70.10 Mainly Beta Single Sheet Ubiquitin Ligase Nedd4; Chain: W; Ubiquitin Ligase Nedd4; Chain: W; 5cq2A02
2JXWA 2F21A 1ZCNA 3KCEA 2EZ5W 2ITKA 4U84A 3KAFA 2ZQTA 5CQ2A 1TK7A 2LAJA 1NMVA 2DWVA 4QIBA 3L4HA 2RE3A 2MDIA 3NTPA 2XP8A 2YSIA 3TDBA 2JMFA 2YSGA 3TCZA 2ZQVA 2XP9A 3KABA 2KXQA 2XP7A 2JX8A 4U85A 2XP3A 3KAGA 1YW5A 2M8IA 2YSBA 3LE4A 1WMVA 2XP4A 4U86A 3M85A 2XPBA 2ZR6A 3WH0A 2ZQUA 2JV4A 3KAHA 2M3OW 2YSHA 3ODKA 1K9QA 1K9RA 4E5RA 2ZR4A 1JMQA 2E45A 1F8AB 2M8JA 3TC5A 4REXA 2L4JA 5AHTA 3CNGA 2YSFA 3M7NA 1EG4A 1EG3A 2DJYA 2ZR5A 2BA1A 2DK1A 3OOBA 1O6WA 2XP5A 3KAIA 2DK7A 2ZQSA 2XP6A 1WR7A 3KADA 1I5HW 2Q5AA 2XPAA 1PINA 2DMVA 2ZAJA
chains in the Genus database with same CATH superfamily
2JXWA 2F21A 1ZCNA 3KCEA 2EZ5W 2ITKA 4U84A 3KAFA 2ZQTA 5U47A 2OWOA 5CQ2A 3FS8A 3MQGA 4GLXA 1TK7A 2LAJA 1NMVA 2DWVA 4QIBA 3L4HA 2RE3A 2MDIA 3MCBA 2XP8A 3NTPA 2YSIA 3TDBA 2JMFA 2YSGA 2QRVA 3TCZA 2ZQVA 2XP9A 5E65A 3KABA 2KXQA 2XP7A 2JX8A 3MQHA 4U85A 2XP3A 3KAGA 1YW5A 2M8IA 2YSBA 4A0TA 3LE4A 1WMVA 2XP4A 4U86A 3M85A 2XPBA 3MCBB 2ZR6A 3WH0A 2ZQUA 5E62A 2JV4A 3KAHA 2M3OW 2YSHA 3ODKA 1K9QA 1K9RA 3PQHA 1TR8A 1RP5A 4E5RA 2ZR4A 1JMQA 2E45A 1F8AB 2M8JA 3TC5A 4REXA 2L4JA 5AHTA 3CNGA 2YSFA 4A0UA 5E66A 3M7NA 1EG4A 5E5WA 1FLCA 2YAJB 1EG3A 2DJYA 3LKXA 2WADA 5E64A 2ZR5A 2BA1A 2DK1A 2WAEA 3OOBA 3FSBA 3FSCA 1O6WA 2XP5A 3KAIA 2DK7A 2ZQSA 2XP6A 1WR7A 3KADA 2Y8NB 1I5HW 2Q5AA 2XPAA 3LKXB 1PINA 2DMVA 2ZAJA
chains in the Genus database with same CATH topology
2JXWA 2F21A 1ZCNA 3KCEA 2EZ5W 2ITKA 4U84A 3KAFA 2ZQTA 5U47A 2OWOA 5CQ2A 3FS8A 3MQGA 4GLXA 1TK7A 2LAJA 1NMVA 2DWVA 4QIBA 3L4HA 2RE3A 2MDIA 3MCBA 2XP8A 3NTPA 2YSIA 3TDBA 2JMFA 2YSGA 2QRVA 3TCZA 2ZQVA 2XP9A 5E65A 3KABA 2KXQA 2XP7A 2JX8A 3MQHA 4U85A 2XP3A 3KAGA 1YW5A 2M8IA 2YSBA 4A0TA 3LE4A 1WMVA 2XP4A 4U86A 3M85A 2XPBA 3MCBB 2ZR6A 3WH0A 2ZQUA 5E62A 2JV4A 3KAHA 2M3OW 2YSHA 3ODKA 1K9QA 1K9RA 3PQHA 1TR8A 1RP5A 4E5RA 2ZR4A 1JMQA 2E45A 1F8AB 2M8JA 3TC5A 4REXA 2L4JA 5AHTA 3CNGA 2YSFA 4A0UA 5E66A 3M7NA 1EG4A 5E5WA 1FLCA 2YAJB 1EG3A 2DJYA 3LKXA 2WADA 5E64A 2ZR5A 2BA1A 2DK1A 2WAEA 3OOBA 3FSBA 3FSCA 1O6WA 2XP5A 3KAIA 2DK7A 2ZQSA 2XP6A 1WR7A 3KADA 2Y8NB 1I5HW 2Q5AA 2XPAA 3LKXB 1PINA 2DMVA 2ZAJA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2JXW A;  2F21 A;  1ZCN A;  3KCE A;  2EZ5 W;  2ITK A;  4U84 A;  3KAF A;  2ZQT A;  5CQ2 A;  1TK7 A;  2LAJ A;  1NMV A;  2DWV A;  4QIB A;  3L4H A;  2RE3 A;  2MDI A;  3NTP A;  2XP8 A;  2YSI A;  3TDB A;  2JMF A;  2YSG A;  3TCZ A;  2ZQV A;  2XP9 A;  3KAB A;  2KXQ A;  2XP7 A;  2JX8 A;  4U85 A;  2XP3 A;  3KAG A;  1YW5 A;  2M8I A;  2YSB A;  3LE4 A;  1WMV A;  2XP4 A;  4U86 A;  3M85 A;  2XPB A;  2ZR6 A;  3WH0 A;  2ZQU A;  2JV4 A;  3KAH A;  2M3O W;  2YSH A;  3ODK A;  1K9Q A;  1K9R A;  4E5R A;  2ZR4 A;  1JMQ A;  2E45 A;  1F8A B;  2M8J A;  3TC5 A;  4REX A;  2L4J A;  5AHT A;  3CNG A;  2YSF A;  3M7N A;  1EG4 A;  1EG3 A;  2DJY A;  2ZR5 A;  2BA1 A;  2DK1 A;  3OOB A;  1O6W A;  2XP5 A;  3KAI A;  2DK7 A;  2ZQS A;  2XP6 A;  1WR7 A;  3KAD A;  1I5H W;  2Q5A A;  2XPA A;  1PIN A;  2DMV A;  2ZAJ A; 
#chains in the Genus database with same CATH topology
 2JXW A;  2F21 A;  1ZCN A;  3KCE A;  2EZ5 W;  2ITK A;  4U84 A;  3KAF A;  2ZQT A;  5U47 A;  2OWO A;  5CQ2 A;  3FS8 A;  3MQG A;  4GLX A;  1TK7 A;  2LAJ A;  1NMV A;  2DWV A;  4QIB A;  3L4H A;  2RE3 A;  2MDI A;  3MCB A;  2XP8 A;  3NTP A;  2YSI A;  3TDB A;  2JMF A;  2YSG A;  2QRV A;  3TCZ A;  2ZQV A;  2XP9 A;  5E65 A;  3KAB A;  2KXQ A;  2XP7 A;  2JX8 A;  3MQH A;  4U85 A;  2XP3 A;  3KAG A;  1YW5 A;  2M8I A;  2YSB A;  4A0T A;  3LE4 A;  1WMV A;  2XP4 A;  4U86 A;  3M85 A;  2XPB A;  3MCB B;  2ZR6 A;  3WH0 A;  2ZQU A;  5E62 A;  2JV4 A;  3KAH A;  2M3O W;  2YSH A;  3ODK A;  1K9Q A;  1K9R A;  3PQH A;  1TR8 A;  1RP5 A;  4E5R A;  2ZR4 A;  1JMQ A;  2E45 A;  1F8A B;  2M8J A;  3TC5 A;  4REX A;  2L4J A;  5AHT A;  3CNG A;  2YSF A;  4A0U A;  5E66 A;  3M7N A;  1EG4 A;  5E5W A;  1FLC A;  2YAJ B;  1EG3 A;  2DJY A;  3LKX A;  2WAD A;  5E64 A;  2ZR5 A;  2BA1 A;  2DK1 A;  2WAE A;  3OOB A;  3FSB A;  3FSC A;  1O6W A;  2XP5 A;  3KAI A;  2DK7 A;  2ZQS A;  2XP6 A;  1WR7 A;  3KAD A;  2Y8N B;  1I5H W;  2Q5A A;  2XPA A;  3LKX B;  1PIN A;  2DMV A;  2ZAJ A; 
#chains in the Genus database with same CATH homology
 2JXW A;  2F21 A;  1ZCN A;  3KCE A;  2EZ5 W;  2ITK A;  4U84 A;  3KAF A;  2ZQT A;  5U47 A;  2OWO A;  5CQ2 A;  3FS8 A;  3MQG A;  4GLX A;  1TK7 A;  2LAJ A;  1NMV A;  2DWV A;  4QIB A;  3L4H A;  2RE3 A;  2MDI A;  3MCB A;  2XP8 A;  3NTP A;  2YSI A;  3TDB A;  2JMF A;  2YSG A;  2QRV A;  3TCZ A;  2ZQV A;  2XP9 A;  5E65 A;  3KAB A;  2KXQ A;  2XP7 A;  2JX8 A;  3MQH A;  4U85 A;  2XP3 A;  3KAG A;  1YW5 A;  2M8I A;  2YSB A;  4A0T A;  3LE4 A;  1WMV A;  2XP4 A;  4U86 A;  3M85 A;  2XPB A;  3MCB B;  2ZR6 A;  3WH0 A;  2ZQU A;  5E62 A;  2JV4 A;  3KAH A;  2M3O W;  2YSH A;  3ODK A;  1K9Q A;  1K9R A;  3PQH A;  1TR8 A;  1RP5 A;  4E5R A;  2ZR4 A;  1JMQ A;  2E45 A;  1F8A B;  2M8J A;  3TC5 A;  4REX A;  2L4J A;  5AHT A;  3CNG A;  2YSF A;  4A0U A;  5E66 A;  3M7N A;  1EG4 A;  5E5W A;  1FLC A;  2YAJ B;  1EG3 A;  2DJY A;  3LKX A;  2WAD A;  5E64 A;  2ZR5 A;  2BA1 A;  2DK1 A;  2WAE A;  3OOB A;  3FSB A;  3FSC A;  1O6W A;  2XP5 A;  3KAI A;  2DK7 A;  2ZQS A;  2XP6 A;  1WR7 A;  3KAD A;  2Y8N B;  1I5H W;  2Q5A A;  2XPA A;  3LKX B;  1PIN A;  2DMV A;  2ZAJ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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