5CQ2A

Crystal structure of tandem ww domains of itch in complex with txnip peptide
Total Genus 11
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
11
sequence length
80
structure length
76
Chain Sequence
GPLPPGWEKRTDSNGRVYFVNHNTRITQWEDPRSQEKPLPEGWEMRFTVDGIPYFVDHNRRTTTYIDPRTGKSALD
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural basis for the regulatory role of the PPxY motifs in the thioredoxin-interacting protein TXNIP.
pubmed doi rcsb
molecule tags Ligase
source organism Homo sapiens
molecule keywords E3 ubiquitin-protein ligase Itchy homolog
total genus 11
structure length 76
sequence length 80
ec nomenclature ec 2.3.2.26: HECT-type E3 ubiquitin transferase.
pdb deposition date 2015-07-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00397 WW WW domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.20.70.10 Mainly Beta Single Sheet Ubiquitin Ligase Nedd4; Chain: W; Ubiquitin Ligase Nedd4; Chain: W; 5cq2A02
5CQ2A 3KAGA 3KADA 2JX8A 1WMVA 2ZQVA 2E45A 2EZ5W 2XPAA 1WR7A 4U85A 2RE3A 3KAFA 3LE4A 1EG4A 2JXWA 4QIBA 5AHTA 2XPBA 2ZR5A 4U86A 2ZR4A 4E5RA 1I5HW 1K9QA 1EG3A 2XP4A 1NMVA 3M85A 2DMVA 2XP8A 2M8IA 3KCEA 2F21A 2YSFA 2ZR6A 2YSGA 2ZAJA 3KAHA 2XP3A 2DK1A 2DJYA 2MDIA 2XP9A 2YSHA 2XP7A 3KABA 2YSIA 3M7NA 2ZQSA 3L4HA 3ODKA 3TCZA 3TDBA 1TK7A 1ZCNA 3CNGA 1O6WA 2YSBA 2ZQTA 2JMFA 3OOBA 1PINA 2KXQA 2L4JA 1K9RA 2XP5A 3KAIA 2LAJA 3NTPA 3WH0A 2M3OW 2XP6A 2Q5AA 2ZQUA 2BA1A 1F8AB 2JV4A 2DWVA 4U84A 3TC5A 2DK7A 2M8JA 2ITKA 4REXA 1YW5A 1JMQA
chains in the Genus database with same CATH superfamily
3FSBA 5CQ2A 5U47A 3KAGA 2WADA 3KADA 2JX8A 1WMVA 2ZQVA 5E5WA 2E45A 2EZ5W 3FSCA 2XPAA 2OWOA 1WR7A 4U85A 2RE3A 1FLCA 3KAFA 3LE4A 1EG4A 2JXWA 5E64A 4QIBA 5AHTA 2XPBA 2ZR5A 4U86A 2ZR4A 4E5RA 1I5HW 1TR8A 1K9QA 1EG3A 2XP4A 1NMVA 3M85A 2DMVA 2XP8A 2M8IA 3KCEA 2F21A 2YSFA 2ZR6A 5E65A 4A0UA 2YSGA 2ZAJA 3KAHA 2XP3A 2DK1A 2DJYA 2MDIA 2XP9A 3LKXA 2YSHA 5E66A 2XP7A 2YAJB 3KABA 2WAEA 2YSIA 3M7NA 2ZQSA 3L4HA 3ODKA 2Y8NB 3TCZA 3TDBA 3LKXB 1TK7A 1ZCNA 3CNGA 3MQHA 1O6WA 3MCBA 2YSBA 2ZQTA 2JMFA 3OOBA 1PINA 2KXQA 2L4JA 1K9RA 2XP5A 3KAIA 2LAJA 5E62A 3NTPA 3WH0A 3MCBB 3PQHA 2M3OW 3MQGA 2QRVA 2XP6A 2Q5AA 2ZQUA 2BA1A 1F8AB 2JV4A 2DWVA 4U84A 3TC5A 2DK7A 1RP5A 2M8JA 2ITKA 4A0TA 4GLXA 4REXA 3FS8A 1YW5A 1JMQA
chains in the Genus database with same CATH topology
3FSBA 5CQ2A 5U47A 3KAGA 2WADA 3KADA 2JX8A 1WMVA 2ZQVA 5E5WA 2E45A 2EZ5W 3FSCA 2XPAA 2OWOA 1WR7A 4U85A 2RE3A 1FLCA 3KAFA 3LE4A 1EG4A 2JXWA 5E64A 4QIBA 5AHTA 2XPBA 2ZR5A 4U86A 2ZR4A 4E5RA 1I5HW 1TR8A 1K9QA 1EG3A 2XP4A 1NMVA 3M85A 2DMVA 2XP8A 2M8IA 3KCEA 2F21A 2YSFA 2ZR6A 5E65A 4A0UA 2YSGA 2ZAJA 3KAHA 2XP3A 2DK1A 2DJYA 2MDIA 2XP9A 3LKXA 2YSHA 5E66A 2XP7A 2YAJB 3KABA 2WAEA 2YSIA 3M7NA 2ZQSA 3L4HA 3ODKA 2Y8NB 3TCZA 3TDBA 3LKXB 1TK7A 1ZCNA 3CNGA 3MQHA 1O6WA 3MCBA 2YSBA 2ZQTA 2JMFA 3OOBA 1PINA 2KXQA 2L4JA 1K9RA 2XP5A 3KAIA 2LAJA 5E62A 3NTPA 3WH0A 3MCBB 3PQHA 2M3OW 3MQGA 2QRVA 2XP6A 2Q5AA 2ZQUA 2BA1A 1F8AB 2JV4A 2DWVA 4U84A 3TC5A 2DK7A 1RP5A 2M8JA 2ITKA 4A0TA 4GLXA 4REXA 3FS8A 1YW5A 1JMQA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5CQ2 A;  3KAG A;  3KAD A;  2JX8 A;  1WMV A;  2ZQV A;  2E45 A;  2EZ5 W;  2XPA A;  1WR7 A;  4U85 A;  2RE3 A;  3KAF A;  3LE4 A;  1EG4 A;  2JXW A;  4QIB A;  5AHT A;  2XPB A;  2ZR5 A;  4U86 A;  2ZR4 A;  4E5R A;  1I5H W;  1K9Q A;  1EG3 A;  2XP4 A;  1NMV A;  3M85 A;  2DMV A;  2XP8 A;  2M8I A;  3KCE A;  2F21 A;  2YSF A;  2ZR6 A;  2YSG A;  2ZAJ A;  3KAH A;  2XP3 A;  2DK1 A;  2DJY A;  2MDI A;  2XP9 A;  2YSH A;  2XP7 A;  3KAB A;  2YSI A;  3M7N A;  2ZQS A;  3L4H A;  3ODK A;  3TCZ A;  3TDB A;  1TK7 A;  1ZCN A;  3CNG A;  1O6W A;  2YSB A;  2ZQT A;  2JMF A;  3OOB A;  1PIN A;  2KXQ A;  2L4J A;  1K9R A;  2XP5 A;  3KAI A;  2LAJ A;  3NTP A;  3WH0 A;  2M3O W;  2XP6 A;  2Q5A A;  2ZQU A;  2BA1 A;  1F8A B;  2JV4 A;  2DWV A;  4U84 A;  3TC5 A;  2DK7 A;  2M8J A;  2ITK A;  4REX A;  1YW5 A;  1JMQ A; 
#chains in the Genus database with same CATH topology
 3FSB A;  5CQ2 A;  5U47 A;  3KAG A;  2WAD A;  3KAD A;  2JX8 A;  1WMV A;  2ZQV A;  5E5W A;  2E45 A;  2EZ5 W;  3FSC A;  2XPA A;  2OWO A;  1WR7 A;  4U85 A;  2RE3 A;  1FLC A;  3KAF A;  3LE4 A;  1EG4 A;  2JXW A;  5E64 A;  4QIB A;  5AHT A;  2XPB A;  2ZR5 A;  4U86 A;  2ZR4 A;  4E5R A;  1I5H W;  1TR8 A;  1K9Q A;  1EG3 A;  2XP4 A;  1NMV A;  3M85 A;  2DMV A;  2XP8 A;  2M8I A;  3KCE A;  2F21 A;  2YSF A;  2ZR6 A;  5E65 A;  4A0U A;  2YSG A;  2ZAJ A;  3KAH A;  2XP3 A;  2DK1 A;  2DJY A;  2MDI A;  2XP9 A;  3LKX A;  2YSH A;  5E66 A;  2XP7 A;  2YAJ B;  3KAB A;  2WAE A;  2YSI A;  3M7N A;  2ZQS A;  3L4H A;  3ODK A;  2Y8N B;  3TCZ A;  3TDB A;  3LKX B;  1TK7 A;  1ZCN A;  3CNG A;  3MQH A;  1O6W A;  3MCB A;  2YSB A;  2ZQT A;  2JMF A;  3OOB A;  1PIN A;  2KXQ A;  2L4J A;  1K9R A;  2XP5 A;  3KAI A;  2LAJ A;  5E62 A;  3NTP A;  3WH0 A;  3MCB B;  3PQH A;  2M3O W;  3MQG A;  2QRV A;  2XP6 A;  2Q5A A;  2ZQU A;  2BA1 A;  1F8A B;  2JV4 A;  2DWV A;  4U84 A;  3TC5 A;  2DK7 A;  1RP5 A;  2M8J A;  2ITK A;  4A0T A;  4GLX A;  4REX A;  3FS8 A;  1YW5 A;  1JMQ A; 
#chains in the Genus database with same CATH homology
 3FSB A;  5CQ2 A;  5U47 A;  3KAG A;  2WAD A;  3KAD A;  2JX8 A;  1WMV A;  2ZQV A;  5E5W A;  2E45 A;  2EZ5 W;  3FSC A;  2XPA A;  2OWO A;  1WR7 A;  4U85 A;  2RE3 A;  1FLC A;  3KAF A;  3LE4 A;  1EG4 A;  2JXW A;  5E64 A;  4QIB A;  5AHT A;  2XPB A;  2ZR5 A;  4U86 A;  2ZR4 A;  4E5R A;  1I5H W;  1TR8 A;  1K9Q A;  1EG3 A;  2XP4 A;  1NMV A;  3M85 A;  2DMV A;  2XP8 A;  2M8I A;  3KCE A;  2F21 A;  2YSF A;  2ZR6 A;  5E65 A;  4A0U A;  2YSG A;  2ZAJ A;  3KAH A;  2XP3 A;  2DK1 A;  2DJY A;  2MDI A;  2XP9 A;  3LKX A;  2YSH A;  5E66 A;  2XP7 A;  2YAJ B;  3KAB A;  2WAE A;  2YSI A;  3M7N A;  2ZQS A;  3L4H A;  3ODK A;  2Y8N B;  3TCZ A;  3TDB A;  3LKX B;  1TK7 A;  1ZCN A;  3CNG A;  3MQH A;  1O6W A;  3MCB A;  2YSB A;  2ZQT A;  2JMF A;  3OOB A;  1PIN A;  2KXQ A;  2L4J A;  1K9R A;  2XP5 A;  3KAI A;  2LAJ A;  5E62 A;  3NTP A;  3WH0 A;  3MCB B;  3PQH A;  2M3O W;  3MQG A;  2QRV A;  2XP6 A;  2Q5A A;  2ZQU A;  2BA1 A;  1F8A B;  2JV4 A;  2DWV A;  4U84 A;  3TC5 A;  2DK7 A;  1RP5 A;  2M8J A;  2ITK A;  4A0T A;  4GLX A;  4REX A;  3FS8 A;  1YW5 A;  1JMQ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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