1DX5I

Crystal structure of the thrombin-thrombomodulin complex
Total Genus 15
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
15
sequence length
118
structure length
118
Chain Sequence
VEPVDPCFRANCEYQCQPLDQTSYLCVCAEGFAPIPHEPHRCQMFCNQTACPADCDPNTQASCECPEGYILDDGFICTDIDECENGGFCSGVCHNLPGTFECICGPDSALAGQIGTDC
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural Basis for the Anticoagulant Activity of the Thrombin-Thrombomodulin Complex
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Homo sapiens
molecule keywords Thrombin light chain
total genus 15
structure length 118
sequence length 118
chains with identical sequence J, K, L
ec nomenclature
pdb deposition date 1999-12-20
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.25.10 Mainly Beta Ribbon Laminin Laminin 1dx5I01
2.10.25.10 Mainly Beta Ribbon Laminin Laminin 1dx5I03
2.10.25.10 Mainly Beta Ribbon Laminin Laminin 1dx5I02
3SOBB 2P28B 4FM5A 1Z6EL 1EMOA 1XFEA 2F9BL 2BOHA 2UWPB 4Y79B 1DVAL 3ZYGA 4YZUB 1EPJA 1EPIA 1NFWB 2KL7A 2P16L 4TGFA 1IVOC 2WPHE 1DX5I 2W2QE 1APQA 1U8CB 1NFXB 1EBVA 2WPLE 5L2ZL 5JBCE 3POYA 1G1TA 1EPHA 4CUEA 4Z0LA 1IQLL 3TBDA 2RNLA 3V64C 3BT2A 2W26B 2BO2A 4XBMA 1MOXC 2XBYL 1MQ6L 4G1MB 3LC5B 2H9EL 3ASIA 1IQNL 1IQJL 2FD6A 1DQBA 2UWOB 1TOZA 3QMOA 5JW1A 1IGXA 1IQHL 4X8UL 3KQBL 2BOKL 4E1GA 3SOQA 5IKRA 3N8YB 1IP0A 2B7DL 3HO3A 3R05A 5CISA 5L2YL 4BTIA 1YUGA 1EAIC 3F6UL 3LIWB 2M74A 2EI8B 1IQGL 4OTYA 1G1QA 1NFUB 3OLTA 1K37A 4BDWA 1V3XB 1HAFA 2EI6B 4PH9A 4CUDA 1OB1C 1K36A 3QH0A 2BOUA 1W8BL 4COXA 4RRXA 1FFMA 1FE2A 1MQ5L 2P93L 2W2ME 5I46L 3MDLA 4MMZB 1W7XL 1EZQB 2VVUL 4ZXYL 3LTGD 2BOXA 2BQWA 2DDUA 3TK6B 2EI7B 1KSNB 1PFXL 4ZAEB 1URKA 3N8YA 3N8XA 1LPGA 3LN1A 3Q3KB 1LPZA 2PUQL 1N7DA 2Y80B 3LAQA 4CUFA 2UWLB 3LTFB 1IOXA 1EQHA 2WYJB 3NJPC 1XDTR 1PGEA 4XL1A 1CCFA 4RRWA 1YO8A 1BF9A 2Y7ZB 4O02B 2VVVL 1CEJA 1NFYB 3HS5A 4AQTA 4ZXXL 3ZYIB 2PHBB 1HAEA 3KQDL 1HREA 4X8VL 3CS7L 1Q4GA 2XC0L 4NG9L 2VH6B 2VWMK 3TGFA 4YT6L 2XC5L 3PGHA 1B9WA 1GK5A 2P94L 4MMYB 1APOA 1FF7A 1LMJA 1G2MB 3FCSB 2MHPA 3MQEA 2WFTA 1NQLB 1G2LB 2CJIB 1HT8A 1ATEA 3SW2A 3KCGL 2J94B 3NTBA 1EGFA 3GCXE 1M1XB 1P0SL 2G00L 3U73A 4BTTA 3DEMA 1HZ8A 1CCVA 2OYUP 2KV4A 1COUA 2JKHL 2Y81B 3GISX 1HX2A 3SOVA 5KIRA 1QFKL 2Y5FL 5CKMA 1F0RB 2RHPA 5CKNA 4M10A 3K9XA 5JB8E 2YGPA 3FBYA 1UZKA 2K2TA 1JBUL 1XKBA 1CVWL 1TLEA 2MGPA 3HPTA 1UZQA 3CFWA 4YT7L 2W3KB 1F7MA 2WYGB 1WU1B 3ELAL 1KIGL 1DIYA 2J34B 3N8WB 4JZFL 1ZAQA 2Y7XB 1X7AL 2Y5HL 5IKVA 2OYEP 1FSBA 2PR3B 2XBXL 3U7UG 1EQGA 2NPRA 3N8ZA 4NGAL 1HT5A 5JB9E 2RA0L 1TPGA 2J4IB 4NA9L 4CSYA 1YGCL 4A7IA 1G1RA 3Q7DA 2XC4L 3HO4A 4XLWA 5JBAE 4ZH8B 1IQKL 1YUKB 2W3IB 2BQ7A 5COXA 5E8DA 3OLUA 1PRHA 2WPME 3P5BL 1F7EA 1IQFL 2W2NE 4MMXB 2W2OE 5JVYA 1WHFA 4X8TL 3QCWA 3LN0A 2VVCK 3FFGL 1A3PA 1L5GB 1CQEA 2W86A 2P3TA 4ZHAB 1NZIA 3N8WA 5IKQA 1L3YA 3KQCL 2FLRL 3C9AC 2P3UA 3IJEB 3BT1A 1IOEL 2XBVL 4D0FA 2FLGA 2VWOL 4BXWA 1LPKA 3ENSA 1JV2B 4JZEL 4JYVL 5F1AA 1SZBA 3N8VA 5KN5C 4Y76B 1I0UA 4Y7AB 2FLBL 2WPIE 1HRFA 2Y5GL 2VWLL 1FJSL 2ADXA 5CKQA 1IQML 1HCGB 2AYLA 2J2UB 3KRKA 2TGFA 2BZ6L 2WPJE 4X8SL 2J95B 4BXSA 3TZIA 2WG4B 2K2SB 3TH3L 1PXXA 1F0SB 1IQIL 3F1SB 1UZJA 2P3FL 1EPGA 2XBWL 3ZYJB 4ISIL 4Y71B 1JL9A 2WPKE 4Y6DB 1HJ7A 1N1IA 3V65B 2VH0B 2W2PE 4RS0A 1AUTL 3EGFA 3RR3A 3CENL 2P3FN 1FAXL 2D1JB 2WG3C 3NT1A 1IQEL 3KL6B 5F19A 3GCWE 1FAKL 1C5MF 4Z0KB 1ATBA 5IKTA 2Y82B 1U67A 3CA7A 4BTUA 1EMNA 2I9AA 4LORA 4RRYA 3HS6A 1DDXA 3HS7A 1IJQA 2P95L 1LQDA 4RUTA 3BPSE 4O1ZA 5L30L 1P9JA 1KLJL 3NTGA 1J9CL 1O5DL 1YUFA 4JYUL 1KLOA 3LC3B 1CVUA 1CX2A 1WHEA 3TK5B 5K0HB 1UZPA 4C16A 1XKAL 1ADXA 4JZDL 4Z6AL 2Y38A 3HO5A 2KB9A 5FDQA 4M11A 4D0EA 1RFNB 1G1SA 3KK6A 5JBBE 2YGOA 2VJ3A 2I9BA 2J38B 4D90A 2WFXB 5JVZA 2MGRA 4Y7BB 2VWNL 3M36L 3H5CB 2BQ6A 4BDXA 4ISHL 5EGMB 1ATAA 1PTHA 2FZZL 3KQEL 1IGZA 4LMFA 1NT0A 1KLIL 3M37L 2BMGA 2Q1JB 1NPEB 1Z6CA 6COXA 2P26A 4RRZA 4OTJA 1ATDA 2GD4A 3IITB
chains in the Genus database with same CATH superfamily
3SOBB 2P28B 4FM5A 1Z6EL 1EMOA 1XFEA 2F9BL 2BOHA 2UWPB 4Y79B 1DVAL 3ZYGA 4YZUB 1EPJA 1EPIA 1NFWB 2HORA 2KL7A 2P16L 4TGFA 1IVOC 2WPHE 1DX5I 2W2QE 1APQA 1U8CB 1NFXB 4A94C 1EBVA 2WPLE 5L2ZL 5JBCE 3POYA 1G1TA 4GU3A 1EPHA 4CUEA 4Z0LA 1IQLL 3TBDA 2RNLA 3V64C 3BT2A 2W26B 2BO2A 4XBMA 1MOXC 2XBYL 1MQ6L 4G1MB 3LC5B 2H9EL 3ASIA 1IQNL 1IQJL 2FD6A 1DQBA 2UWOB 1TOZA 3QMOA 5JW1A 1IGXA 1IQHL 4X8UL 3KQBL 2BOKL 4E1GA 4GU4A 3SOQA 5IKRA 3N8YB 1IP0A 2B7DL 3HO3A 3R05A 5CISA 1QIUA 5L2YL 4BTIA 1YUGA 1EAIC 3F6UL 3LIWB 2M74A 2EI8B 1IQGL 4OTYA 1V1IA 1G1QA 1NFUB 3OLTA 1K37A 4BDWA 1V3XB 1HAFA 2EI6B 4PH9A 4CUDA 1OB1C 1K36A 3QH0A 2BOUA 1W8BL 4COXA 4RRXA 1FFMA 1FE2A 1MQ5L 2P93L 2W2ME 5I46L 3MDLA 4MMZB 1W7XL 1EZQB 2VVUL 4ZXYL 3LTGD 2BOXA 2BQWA 2DDUA 3TK6B 2EI7B 1KSNB 1PFXL 4ZAEB 1URKA 3N8YA 3N8XA 1LPGA 3LN1A 3Q3KB 1LPZA 2PUQL 1N7DA 2Y80B 3LAQA 4CUFA 2UWLB 3LTFB 1IOXA 1EQHA 2WYJB 3NJPC 1XDTR 1PGEA 4XL1A 1CCFA 4RRWA 1YO8A 1BF9A 2Y7ZB 1LMMA 2H9EC 4O02B 2VVVL 1CEJA 1NFYB 3HS5A 4AQTA 4ZXXL 3ZYIB 2PHBB 1HAEA 3KQDL 1HREA 4X8VL 3CS7L 1Q4GA 2XC0L 4NG9L 2VH6B 2VWMK 3TGFA 4YT6L 2XC5L 3PGHA 1B9WA 1GK5A 2P94L 4MMYB 1APOA 1FF7A 1LMJA 1G2MB 3FCSB 2MHPA 3MQEA 2WFTA 1NQLB 1G2LB 2CJIB 1HT8A 1ATEA 2HOXA 3KCGL 3SW2A 2J94B 3NTBA 1EGFA 3GCXE 1M1XB 1P0SL 1V1HA 2G00L 3U73A 4BTTA 1KKEA 3DEMA 1HZ8A 1CCVA 2OYUP 2KV4A 1COUA 2JKHL 2Y81B 3GISX 1HX2A 3SOVA 5KIRA 1QFKL 2BSFA 2Y5FL 5CKMA 1F0RB 2RHPA 5CKNA 4M10A 3K9XA 5JB8E 2YGPA 3FBYA 1UZKA 2YGQA 2K2TA 1JBUL 1XKBA 1CVWL 1TLEA 2MGPA 3HPTA 1UZQA 3CFWA 4YT7L 2W3KB 1F7MA 2WYGB 1WU1B 3ELAL 1KIGL 1DIYA 2WZPP 2J34B 3N8WB 4JZFL 1ZAQA 2Y7XB 1X7AL 2Y5HL 5IKVA 2OYEP 1FSBA 2PR3B 2XBXL 3U7UG 1EQGA 2NPRA 3N8ZA 4NGAL 1HT5A 5JB9E 2RA0L 1TPGA 2J4IB 4NA9L 4CSYA 1YGCL 4A7IA 1G1RA 3Q7DA 2XC4L 3HO4A 4XLWA 5JBAE 4ZH8B 1IQKL 1YUKB 2W3IB 2BQ7A 5COXA 5E8DA 3OLUA 1PRHA 2WPME 3P5BL 1F7EA 1IQFL 2W2NE 4MMXB 2W2OE 5JVYA 1WHFA 4X8TL 3QCWA 3LN0A 2VVCK 3FFGL 1A3PA 1L5GB 1CQEA 2W86A 2P3TA 4ZHAB 1NZIA 3N8WA 5IKQA 1L3YA 3KQCL 2BT7A 2FLRL 3C9AC 3IJEB 2P3UA 3BT1A 1IOEL 2XBVL 4D0FA 2FLGA 2VWOL 4BXWA 1LPKA 3ENSA 1JV2B 4JZEL 4JYVL 5F1AA 1SZBA 3N8VA 5KN5C 4Y76B 1I0UA 4Y7AB 2FLBL 2WPIE 1HRFA 2Y5GL 2VWLL 1FJSL 2ADXA 5CKQA 1IQML 1HCGB 2AYLA 2J2UB 3KRKA 2TGFA 2BZ6L 2WPJE 4X8SL 2J95B 4BXSA 3TZIA 2WG4B 2K2SB 3TH3L 1PXXA 1F0SB 1IQIL 2BT8A 3F1SB 1UZJA 2P3FL 1EPGA 2XBWL 3ZYJB 4ISIL 4Y71B 1JL9A 2WPKE 4Y6DB 1HJ7A 1N1IA 3V65B 2VH0B 2W2PE 4RS0A 1AUTL 3EGFA 3RR3A 3CENL 2P3FN 1FAXL 2D1JB 2WG3C 3NT1A 1IQEL 3KL6B 5F19A 3GCWE 1FAKL 1C5MF 4Z0KB 1ATBA 5IKTA 2Y82B 1U67A 3CA7A 4BTUA 1EMNA 2I9AA 4LORA 4RRYA 3HS6A 1DDXA 3HS7A 1IJQA 2P95L 1LQDA 4RUTA 3BPSE 4O1ZA 5L30L 1P9JA 1KLJL 3NTGA 1J9CL 1LK9A 1O5DL 1YUFA 4JYUL 1KLOA 3LC3B 1CVUA 1CX2A 1WHEA 3TK5B 5K0HB 1UZPA 4C16A 1XKAL 1ADXA 4JZDL 4Z6AL 2Y38A 3HO5A 2KNIA 2KB9A 5FDQA 4M11A 4D0EA 1RFNB 1G1SA 3KK6A 5JBBE 2YGOA 2VJ3A 2I9BA 2J38B 4D90A 2WFXB 5JVZA 2MGRA 4Y7BB 2VRSA 2VWNL 3M36L 3H5CB 2BQ6A 4BDXA 4ISHL 5EGMB 1ATAA 1PTHA 2FZZL 3KQEL 1IGZA 4LMFA 1NT0A 1KLIL 3S6XA 3M37L 2BMGA 2Q1JB 1NPEB 1Z6CA 6COXA 2P26A 4RRZA 2JJLA 4OTJA 1ATDA 2GD4A 3IITB
chains in the Genus database with same CATH topology
3SOBB 2P28B 4FM5A 1Z6EL 1EMOA 1XFEA 2F9BL 2BOHA 2UWPB 4Y79B 1DVAL 3ZYGA 4YZUB 1EPJA 1EPIA 1NFWB 2KL7A 2P16L 4TGFA 1IVOC 2WPHE 1DX5I 2W2QE 1APQA 1U8CB 1NFXB 4A94C 1EBVA 2WPLE 5L2ZL 5JBCE 3POYA 1G1TA 1EPHA 4CUEA 4Z0LA 1IQLL 3TBDA 2RNLA 3V64C 3BT2A 2W26B 2BO2A 4XBMA 1MOXC 2XBYL 1MQ6L 4G1MB 3LC5B 2H9EL 3ASIA 1IQNL 1IQJL 2FD6A 1DQBA 2UWOB 1TOZA 3QMOA 5JW1A 1IGXA 1IQHL 4X8UL 3KQBL 2BOKL 4E1GA 3SOQA 5IKRA 3N8YB 1IP0A 2B7DL 3HO3A 3R05A 5CISA 5L2YL 4BTIA 1YUGA 1EAIC 3F6UL 3LIWB 2M74A 2EI8B 1IQGL 4OTYA 1G1QA 1NFUB 3OLTA 1K37A 4BDWA 1V3XB 1HAFA 2EI6B 4PH9A 4CUDA 1OB1C 1K36A 3QH0A 2BOUA 1W8BL 4COXA 4RRXA 1FFMA 1FE2A 1MQ5L 2P93L 2W2ME 5I46L 3MDLA 4MMZB 1W7XL 1EZQB 2VVUL 4ZXYL 3LTGD 2BOXA 2BQWA 2DDUA 3TK6B 2EI7B 1KSNB 1PFXL 4ZAEB 1URKA 3N8YA 3N8XA 1LPGA 3LN1A 3Q3KB 1LPZA 2PUQL 1N7DA 2Y80B 3LAQA 4CUFA 2UWLB 3LTFB 1IOXA 1EQHA 2WYJB 3NJPC 1XDTR 1PGEA 4XL1A 1CCFA 4RRWA 1YO8A 1BF9A 2Y7ZB 1LMMA 2H9EC 4O02B 2VVVL 1CEJA 1NFYB 3HS5A 4AQTA 4ZXXL 3ZYIB 2PHBB 1HAEA 3KQDL 1HREA 4X8VL 3CS7L 1Q4GA 2XC0L 4NG9L 2VH6B 2VWMK 3TGFA 4YT6L 2XC5L 3PGHA 1B9WA 1GK5A 2P94L 4MMYB 1APOA 1FF7A 1LMJA 1G2MB 3FCSB 2MHPA 3MQEA 2WFTA 1NQLB 1G2LB 2CJIB 1HT8A 1ATEA 3SW2A 3KCGL 2J94B 3NTBA 1EGFA 3GCXE 1M1XB 1P0SL 2G00L 3U73A 4BTTA 3DEMA 1HZ8A 1CCVA 2OYUP 2KV4A 1COUA 2JKHL 2Y81B 3GISX 1HX2A 3SOVA 5KIRA 1QFKL 2Y5FL 5CKMA 1F0RB 2RHPA 5CKNA 4M10A 3K9XA 5JB8E 2YGPA 3FBYA 1UZKA 2YGQA 2K2TA 1JBUL 1XKBA 1CVWL 1TLEA 2MGPA 3HPTA 1UZQA 3CFWA 4YT7L 2W3KB 1F7MA 2WYGB 1WU1B 3ELAL 1KIGL 1DIYA 2WZPP 2J34B 3N8WB 4JZFL 1ZAQA 2Y7XB 1X7AL 2Y5HL 5IKVA 2OYEP 1FSBA 2PR3B 2XBXL 3U7UG 1EQGA 2NPRA 3N8ZA 4NGAL 1HT5A 5JB9E 2RA0L 1TPGA 2J4IB 4NA9L 4CSYA 1YGCL 4A7IA 1G1RA 3Q7DA 2XC4L 3HO4A 4XLWA 5JBAE 4ZH8B 1IQKL 1YUKB 2W3IB 2BQ7A 5COXA 5E8DA 3OLUA 1PRHA 2WPME 3P5BL 1F7EA 1IQFL 2W2NE 4MMXB 2W2OE 5JVYA 1WHFA 4X8TL 3QCWA 3LN0A 2VVCK 3FFGL 1A3PA 1L5GB 1CQEA 2W86A 2P3TA 4ZHAB 1NZIA 3N8WA 5IKQA 1L3YA 3KQCL 2FLRL 3C9AC 2P3UA 3IJEB 3BT1A 1IOEL 2XBVL 4D0FA 2FLGA 2VWOL 4BXWA 1LPKA 3ENSA 1JV2B 4JZEL 4JYVL 5F1AA 1SZBA 3N8VA 5KN5C 4Y76B 1I0UA 4Y7AB 2FLBL 2WPIE 1HRFA 2Y5GL 2VWLL 1FJSL 2ADXA 5CKQA 1IQML 1HCGB 2AYLA 2J2UB 3KRKA 2TGFA 2BZ6L 2WPJE 4X8SL 2J95B 4BXSA 3TZIA 2WG4B 2K2SB 3TH3L 1PXXA 1F0SB 1IQIL 3F1SB 1UZJA 2P3FL 1EPGA 2XBWL 3ZYJB 4ISIL 4Y71B 1JL9A 2WPKE 4Y6DB 1HJ7A 1N1IA 3V65B 2VH0B 2W2PE 4RS0A 1AUTL 3EGFA 3RR3A 3CENL 2P3FN 1FAXL 2D1JB 2WG3C 3NT1A 1IQEL 3KL6B 5F19A 3GCWE 1FAKL 1C5MF 4Z0KB 1ATBA 5IKTA 2Y82B 1U67A 3CA7A 4BTUA 1EMNA 2I9AA 4LORA 4RRYA 3HS6A 1DDXA 3HS7A 1IJQA 2P95L 1LQDA 4RUTA 3BPSE 4O1ZA 5L30L 1P9JA 1KLJL 3NTGA 1J9CL 1O5DL 1YUFA 4JYUL 1KLOA 3LC3B 1CVUA 1CX2A 1WHEA 3TK5B 5K0HB 1UZPA 4C16A 1XKAL 1ADXA 4JZDL 4Z6AL 2Y38A 3HO5A 2KNIA 2KB9A 5FDQA 4M11A 4D0EA 1RFNB 1G1SA 3KK6A 5JBBE 2YGOA 2VJ3A 2I9BA 2J38B 4D90A 2WFXB 5JVZA 2MGRA 4Y7BB 2VWNL 3M36L 3H5CB 2BQ6A 4BDXA 4ISHL 5EGMB 1ATAA 1PTHA 2FZZL 3KQEL 1IGZA 4LMFA 1NT0A 1KLIL 3S6XA 3M37L 2BMGA 2Q1JB 1NPEB 1Z6CA 6COXA 2P26A 4RRZA 4OTJA 1ATDA 2GD4A 3IITB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3SOB B;  2P28 B;  4FM5 A;  1Z6E L;  1EMO A;  1XFE A;  2F9B L;  2BOH A;  2UWP B;  4Y79 B;  1DVA L;  3ZYG A;  4YZU B;  1EPJ A;  1EPI A;  1NFW B;  2KL7 A;  2P16 L;  4TGF A;  1IVO C;  2WPH E;  1DX5 I;  2W2Q E;  1APQ A;  1U8C B;  1NFX B;  1EBV A;  2WPL E;  5L2Z L;  5JBC E;  3POY A;  1G1T A;  1EPH A;  4CUE A;  4Z0L A;  1IQL L;  3TBD A;  2RNL A;  3V64 C;  3BT2 A;  2W26 B;  2BO2 A;  4XBM A;  1MOX C;  2XBY L;  1MQ6 L;  4G1M B;  3LC5 B;  2H9E L;  3ASI A;  1IQN L;  1IQJ L;  2FD6 A;  1DQB A;  2UWO B;  1TOZ A;  3QMO A;  5JW1 A;  1IGX A;  1IQH L;  4X8U L;  3KQB L;  2BOK L;  4E1G A;  3SOQ A;  5IKR A;  3N8Y B;  1IP0 A;  2B7D L;  3HO3 A;  3R05 A;  5CIS A;  5L2Y L;  4BTI A;  1YUG A;  1EAI C;  3F6U L;  3LIW B;  2M74 A;  2EI8 B;  1IQG L;  4OTY A;  1G1Q A;  1NFU B;  3OLT A;  1K37 A;  4BDW A;  1V3X B;  1HAF A;  2EI6 B;  4PH9 A;  4CUD A;  1OB1 C;  1K36 A;  3QH0 A;  2BOU A;  1W8B L;  4COX A;  4RRX A;  1FFM A;  1FE2 A;  1MQ5 L;  2P93 L;  2W2M E;  5I46 L;  3MDL A;  4MMZ B;  1W7X L;  1EZQ B;  2VVU L;  4ZXY L;  3LTG D;  2BOX A;  2BQW A;  2DDU A;  3TK6 B;  2EI7 B;  1KSN B;  1PFX L;  4ZAE B;  1URK A;  3N8Y A;  3N8X A;  1LPG A;  3LN1 A;  3Q3K B;  1LPZ A;  2PUQ L;  1N7D A;  2Y80 B;  3LAQ A;  4CUF A;  2UWL B;  3LTF B;  1IOX A;  1EQH A;  2WYJ B;  3NJP C;  1XDT R;  1PGE A;  4XL1 A;  1CCF A;  4RRW A;  1YO8 A;  1BF9 A;  2Y7Z B;  4O02 B;  2VVV L;  1CEJ A;  1NFY B;  3HS5 A;  4AQT A;  4ZXX L;  3ZYI B;  2PHB B;  1HAE A;  3KQD L;  1HRE A;  4X8V L;  3CS7 L;  1Q4G A;  2XC0 L;  4NG9 L;  2VH6 B;  2VWM K;  3TGF A;  4YT6 L;  2XC5 L;  3PGH A;  1B9W A;  1GK5 A;  2P94 L;  4MMY B;  1APO A;  1FF7 A;  1LMJ A;  1G2M B;  3FCS B;  2MHP A;  3MQE A;  2WFT A;  1NQL B;  1G2L B;  2CJI B;  1HT8 A;  1ATE A;  3SW2 A;  3KCG L;  2J94 B;  3NTB A;  1EGF A;  3GCX E;  1M1X B;  1P0S L;  2G00 L;  3U73 A;  4BTT A;  3DEM A;  1HZ8 A;  1CCV A;  2OYU P;  2KV4 A;  1COU A;  2JKH L;  2Y81 B;  3GIS X;  1HX2 A;  3SOV A;  5KIR A;  1QFK L;  2Y5F L;  5CKM A;  1F0R B;  2RHP A;  5CKN A;  4M10 A;  3K9X A;  5JB8 E;  2YGP A;  3FBY A;  1UZK A;  2K2T A;  1JBU L;  1XKB A;  1CVW L;  1TLE A;  2MGP A;  3HPT A;  1UZQ A;  3CFW A;  4YT7 L;  2W3K B;  1F7M A;  2WYG B;  1WU1 B;  3ELA L;  1KIG L;  1DIY A;  2J34 B;  3N8W B;  4JZF L;  1ZAQ A;  2Y7X B;  1X7A L;  2Y5H L;  5IKV A;  2OYE P;  1FSB A;  2PR3 B;  2XBX L;  3U7U G;  1EQG A;  2NPR A;  3N8Z A;  4NGA L;  1HT5 A;  5JB9 E;  2RA0 L;  1TPG A;  2J4I B;  4NA9 L;  4CSY A;  1YGC L;  4A7I A;  1G1R A;  3Q7D A;  2XC4 L;  3HO4 A;  4XLW A;  5JBA E;  4ZH8 B;  1IQK L;  1YUK B;  2W3I B;  2BQ7 A;  5COX A;  5E8D A;  3OLU A;  1PRH A;  2WPM E;  3P5B L;  1F7E A;  1IQF L;  2W2N E;  4MMX B;  2W2O E;  5JVY A;  1WHF A;  4X8T L;  3QCW A;  3LN0 A;  2VVC K;  3FFG L;  1A3P A;  1L5G B;  1CQE A;  2W86 A;  2P3T A;  4ZHA B;  1NZI A;  3N8W A;  5IKQ A;  1L3Y A;  3KQC L;  2FLR L;  3C9A C;  2P3U A;  3IJE B;  3BT1 A;  1IOE L;  2XBV L;  4D0F A;  2FLG A;  2VWO L;  4BXW A;  1LPK A;  3ENS A;  1JV2 B;  4JZE L;  4JYV L;  5F1A A;  1SZB A;  3N8V A;  5KN5 C;  4Y76 B;  1I0U A;  4Y7A B;  2FLB L;  2WPI E;  1HRF A;  2Y5G L;  2VWL L;  1FJS L;  2ADX A;  5CKQ A;  1IQM L;  1HCG B;  2AYL A;  2J2U B;  3KRK A;  2TGF A;  2BZ6 L;  2WPJ E;  4X8S L;  2J95 B;  4BXS A;  3TZI A;  2WG4 B;  2K2S B;  3TH3 L;  1PXX A;  1F0S B;  1IQI L;  3F1S B;  1UZJ A;  2P3F L;  1EPG A;  2XBW L;  3ZYJ B;  4ISI L;  4Y71 B;  1JL9 A;  2WPK E;  4Y6D B;  1HJ7 A;  1N1I A;  3V65 B;  2VH0 B;  2W2P E;  4RS0 A;  1AUT L;  3EGF A;  3RR3 A;  3CEN L;  2P3F N;  1FAX L;  2D1J B;  2WG3 C;  3NT1 A;  1IQE L;  3KL6 B;  5F19 A;  3GCW E;  1FAK L;  1C5M F;  4Z0K B;  1ATB A;  5IKT A;  2Y82 B;  1U67 A;  3CA7 A;  4BTU A;  1EMN A;  2I9A A;  4LOR A;  4RRY A;  3HS6 A;  1DDX A;  3HS7 A;  1IJQ A;  2P95 L;  1LQD A;  4RUT A;  3BPS E;  4O1Z A;  5L30 L;  1P9J A;  1KLJ L;  3NTG A;  1J9C L;  1O5D L;  1YUF A;  4JYU L;  1KLO A;  3LC3 B;  1CVU A;  1CX2 A;  1WHE A;  3TK5 B;  5K0H B;  1UZP A;  4C16 A;  1XKA L;  1ADX A;  4JZD L;  4Z6A L;  2Y38 A;  3HO5 A;  2KB9 A;  5FDQ A;  4M11 A;  4D0E A;  1RFN B;  1G1S A;  3KK6 A;  5JBB E;  2YGO A;  2VJ3 A;  2I9B A;  2J38 B;  4D90 A;  2WFX B;  5JVZ A;  2MGR A;  4Y7B B;  2VWN L;  3M36 L;  3H5C B;  2BQ6 A;  4BDX A;  4ISH L;  5EGM B;  1ATA A;  1PTH A;  2FZZ L;  3KQE L;  1IGZ A;  4LMF A;  1NT0 A;  1KLI L;  3M37 L;  2BMG A;  2Q1J B;  1NPE B;  1Z6C A;  6COX A;  2P26 A;  4RRZ A;  4OTJ A;  1ATD A;  2GD4 A;  3IIT B; 
#chains in the Genus database with same CATH topology
 3SOB B;  2P28 B;  4FM5 A;  1Z6E L;  1EMO A;  1XFE A;  2F9B L;  2BOH A;  2UWP B;  4Y79 B;  1DVA L;  3ZYG A;  4YZU B;  1EPJ A;  1EPI A;  1NFW B;  2HOR A;  2KL7 A;  2P16 L;  4TGF A;  1IVO C;  2WPH E;  1DX5 I;  2W2Q E;  1APQ A;  1U8C B;  1NFX B;  4A94 C;  1EBV A;  2WPL E;  5L2Z L;  5JBC E;  3POY A;  1G1T A;  4GU3 A;  1EPH A;  4CUE A;  4Z0L A;  1IQL L;  3TBD A;  2RNL A;  3V64 C;  3BT2 A;  2W26 B;  2BO2 A;  4XBM A;  1MOX C;  2XBY L;  1MQ6 L;  4G1M B;  3LC5 B;  2H9E L;  3ASI A;  1IQN L;  1IQJ L;  2FD6 A;  1DQB A;  2UWO B;  1TOZ A;  3QMO A;  5JW1 A;  1IGX A;  1IQH L;  4X8U L;  3KQB L;  2BOK L;  4E1G A;  4GU4 A;  3SOQ A;  5IKR A;  3N8Y B;  1IP0 A;  2B7D L;  3HO3 A;  3R05 A;  5CIS A;  1QIU A;  5L2Y L;  4BTI A;  1YUG A;  1EAI C;  3F6U L;  3LIW B;  2M74 A;  2EI8 B;  1IQG L;  4OTY A;  1V1I A;  1G1Q A;  1NFU B;  3OLT A;  1K37 A;  4BDW A;  1V3X B;  1HAF A;  2EI6 B;  4PH9 A;  4CUD A;  1OB1 C;  1K36 A;  3QH0 A;  2BOU A;  1W8B L;  4COX A;  4RRX A;  1FFM A;  1FE2 A;  1MQ5 L;  2P93 L;  2W2M E;  5I46 L;  3MDL A;  4MMZ B;  1W7X L;  1EZQ B;  2VVU L;  4ZXY L;  3LTG D;  2BOX A;  2BQW A;  2DDU A;  3TK6 B;  2EI7 B;  1KSN B;  1PFX L;  4ZAE B;  1URK A;  3N8Y A;  3N8X A;  1LPG A;  3LN1 A;  3Q3K B;  1LPZ A;  2PUQ L;  1N7D A;  2Y80 B;  3LAQ A;  4CUF A;  2UWL B;  3LTF B;  1IOX A;  1EQH A;  2WYJ B;  3NJP C;  1XDT R;  1PGE A;  4XL1 A;  1CCF A;  4RRW A;  1YO8 A;  1BF9 A;  2Y7Z B;  1LMM A;  2H9E C;  4O02 B;  2VVV L;  1CEJ A;  1NFY B;  3HS5 A;  4AQT A;  4ZXX L;  3ZYI B;  2PHB B;  1HAE A;  3KQD L;  1HRE A;  4X8V L;  3CS7 L;  1Q4G A;  2XC0 L;  4NG9 L;  2VH6 B;  2VWM K;  3TGF A;  4YT6 L;  2XC5 L;  3PGH A;  1B9W A;  1GK5 A;  2P94 L;  4MMY B;  1APO A;  1FF7 A;  1LMJ A;  1G2M B;  3FCS B;  2MHP A;  3MQE A;  2WFT A;  1NQL B;  1G2L B;  2CJI B;  1HT8 A;  1ATE A;  2HOX A;  3KCG L;  3SW2 A;  2J94 B;  3NTB A;  1EGF A;  3GCX E;  1M1X B;  1P0S L;  1V1H A;  2G00 L;  3U73 A;  4BTT A;  1KKE A;  3DEM A;  1HZ8 A;  1CCV A;  2OYU P;  2KV4 A;  1COU A;  2JKH L;  2Y81 B;  3GIS X;  1HX2 A;  3SOV A;  5KIR A;  1QFK L;  2BSF A;  2Y5F L;  5CKM A;  1F0R B;  2RHP A;  5CKN A;  4M10 A;  3K9X A;  5JB8 E;  2YGP A;  3FBY A;  1UZK A;  2YGQ A;  2K2T A;  1JBU L;  1XKB A;  1CVW L;  1TLE A;  2MGP A;  3HPT A;  1UZQ A;  3CFW A;  4YT7 L;  2W3K B;  1F7M A;  2WYG B;  1WU1 B;  3ELA L;  1KIG L;  1DIY A;  2WZP P;  2J34 B;  3N8W B;  4JZF L;  1ZAQ A;  2Y7X B;  1X7A L;  2Y5H L;  5IKV A;  2OYE P;  1FSB A;  2PR3 B;  2XBX L;  3U7U G;  1EQG A;  2NPR A;  3N8Z A;  4NGA L;  1HT5 A;  5JB9 E;  2RA0 L;  1TPG A;  2J4I B;  4NA9 L;  4CSY A;  1YGC L;  4A7I A;  1G1R A;  3Q7D A;  2XC4 L;  3HO4 A;  4XLW A;  5JBA E;  4ZH8 B;  1IQK L;  1YUK B;  2W3I B;  2BQ7 A;  5COX A;  5E8D A;  3OLU A;  1PRH A;  2WPM E;  3P5B L;  1F7E A;  1IQF L;  2W2N E;  4MMX B;  2W2O E;  5JVY A;  1WHF A;  4X8T L;  3QCW A;  3LN0 A;  2VVC K;  3FFG L;  1A3P A;  1L5G B;  1CQE A;  2W86 A;  2P3T A;  4ZHA B;  1NZI A;  3N8W A;  5IKQ A;  1L3Y A;  3KQC L;  2BT7 A;  2FLR L;  3C9A C;  3IJE B;  2P3U A;  3BT1 A;  1IOE L;  2XBV L;  4D0F A;  2FLG A;  2VWO L;  4BXW A;  1LPK A;  3ENS A;  1JV2 B;  4JZE L;  4JYV L;  5F1A A;  1SZB A;  3N8V A;  5KN5 C;  4Y76 B;  1I0U A;  4Y7A B;  2FLB L;  2WPI E;  1HRF A;  2Y5G L;  2VWL L;  1FJS L;  2ADX A;  5CKQ A;  1IQM L;  1HCG B;  2AYL A;  2J2U B;  3KRK A;  2TGF A;  2BZ6 L;  2WPJ E;  4X8S L;  2J95 B;  4BXS A;  3TZI A;  2WG4 B;  2K2S B;  3TH3 L;  1PXX A;  1F0S B;  1IQI L;  2BT8 A;  3F1S B;  1UZJ A;  2P3F L;  1EPG A;  2XBW L;  3ZYJ B;  4ISI L;  4Y71 B;  1JL9 A;  2WPK E;  4Y6D B;  1HJ7 A;  1N1I A;  3V65 B;  2VH0 B;  2W2P E;  4RS0 A;  1AUT L;  3EGF A;  3RR3 A;  3CEN L;  2P3F N;  1FAX L;  2D1J B;  2WG3 C;  3NT1 A;  1IQE L;  3KL6 B;  5F19 A;  3GCW E;  1FAK L;  1C5M F;  4Z0K B;  1ATB A;  5IKT A;  2Y82 B;  1U67 A;  3CA7 A;  4BTU A;  1EMN A;  2I9A A;  4LOR A;  4RRY A;  3HS6 A;  1DDX A;  3HS7 A;  1IJQ A;  2P95 L;  1LQD A;  4RUT A;  3BPS E;  4O1Z A;  5L30 L;  1P9J A;  1KLJ L;  3NTG A;  1J9C L;  1LK9 A;  1O5D L;  1YUF A;  4JYU L;  1KLO A;  3LC3 B;  1CVU A;  1CX2 A;  1WHE A;  3TK5 B;  5K0H B;  1UZP A;  4C16 A;  1XKA L;  1ADX A;  4JZD L;  4Z6A L;  2Y38 A;  3HO5 A;  2KNI A;  2KB9 A;  5FDQ A;  4M11 A;  4D0E A;  1RFN B;  1G1S A;  3KK6 A;  5JBB E;  2YGO A;  2VJ3 A;  2I9B A;  2J38 B;  4D90 A;  2WFX B;  5JVZ A;  2MGR A;  4Y7B B;  2VRS A;  2VWN L;  3M36 L;  3H5C B;  2BQ6 A;  4BDX A;  4ISH L;  5EGM B;  1ATA A;  1PTH A;  2FZZ L;  3KQE L;  1IGZ A;  4LMF A;  1NT0 A;  1KLI L;  3S6X A;  3M37 L;  2BMG A;  2Q1J B;  1NPE B;  1Z6C A;  6COX A;  2P26 A;  4RRZ A;  2JJL A;  4OTJ A;  1ATD A;  2GD4 A;  3IIT B; 
#chains in the Genus database with same CATH homology
 3SOB B;  2P28 B;  4FM5 A;  1Z6E L;  1EMO A;  1XFE A;  2F9B L;  2BOH A;  2UWP B;  4Y79 B;  1DVA L;  3ZYG A;  4YZU B;  1EPJ A;  1EPI A;  1NFW B;  2KL7 A;  2P16 L;  4TGF A;  1IVO C;  2WPH E;  1DX5 I;  2W2Q E;  1APQ A;  1U8C B;  1NFX B;  4A94 C;  1EBV A;  2WPL E;  5L2Z L;  5JBC E;  3POY A;  1G1T A;  1EPH A;  4CUE A;  4Z0L A;  1IQL L;  3TBD A;  2RNL A;  3V64 C;  3BT2 A;  2W26 B;  2BO2 A;  4XBM A;  1MOX C;  2XBY L;  1MQ6 L;  4G1M B;  3LC5 B;  2H9E L;  3ASI A;  1IQN L;  1IQJ L;  2FD6 A;  1DQB A;  2UWO B;  1TOZ A;  3QMO A;  5JW1 A;  1IGX A;  1IQH L;  4X8U L;  3KQB L;  2BOK L;  4E1G A;  3SOQ A;  5IKR A;  3N8Y B;  1IP0 A;  2B7D L;  3HO3 A;  3R05 A;  5CIS A;  5L2Y L;  4BTI A;  1YUG A;  1EAI C;  3F6U L;  3LIW B;  2M74 A;  2EI8 B;  1IQG L;  4OTY A;  1G1Q A;  1NFU B;  3OLT A;  1K37 A;  4BDW A;  1V3X B;  1HAF A;  2EI6 B;  4PH9 A;  4CUD A;  1OB1 C;  1K36 A;  3QH0 A;  2BOU A;  1W8B L;  4COX A;  4RRX A;  1FFM A;  1FE2 A;  1MQ5 L;  2P93 L;  2W2M E;  5I46 L;  3MDL A;  4MMZ B;  1W7X L;  1EZQ B;  2VVU L;  4ZXY L;  3LTG D;  2BOX A;  2BQW A;  2DDU A;  3TK6 B;  2EI7 B;  1KSN B;  1PFX L;  4ZAE B;  1URK A;  3N8Y A;  3N8X A;  1LPG A;  3LN1 A;  3Q3K B;  1LPZ A;  2PUQ L;  1N7D A;  2Y80 B;  3LAQ A;  4CUF A;  2UWL B;  3LTF B;  1IOX A;  1EQH A;  2WYJ B;  3NJP C;  1XDT R;  1PGE A;  4XL1 A;  1CCF A;  4RRW A;  1YO8 A;  1BF9 A;  2Y7Z B;  1LMM A;  2H9E C;  4O02 B;  2VVV L;  1CEJ A;  1NFY B;  3HS5 A;  4AQT A;  4ZXX L;  3ZYI B;  2PHB B;  1HAE A;  3KQD L;  1HRE A;  4X8V L;  3CS7 L;  1Q4G A;  2XC0 L;  4NG9 L;  2VH6 B;  2VWM K;  3TGF A;  4YT6 L;  2XC5 L;  3PGH A;  1B9W A;  1GK5 A;  2P94 L;  4MMY B;  1APO A;  1FF7 A;  1LMJ A;  1G2M B;  3FCS B;  2MHP A;  3MQE A;  2WFT A;  1NQL B;  1G2L B;  2CJI B;  1HT8 A;  1ATE A;  3SW2 A;  3KCG L;  2J94 B;  3NTB A;  1EGF A;  3GCX E;  1M1X B;  1P0S L;  2G00 L;  3U73 A;  4BTT A;  3DEM A;  1HZ8 A;  1CCV A;  2OYU P;  2KV4 A;  1COU A;  2JKH L;  2Y81 B;  3GIS X;  1HX2 A;  3SOV A;  5KIR A;  1QFK L;  2Y5F L;  5CKM A;  1F0R B;  2RHP A;  5CKN A;  4M10 A;  3K9X A;  5JB8 E;  2YGP A;  3FBY A;  1UZK A;  2YGQ A;  2K2T A;  1JBU L;  1XKB A;  1CVW L;  1TLE A;  2MGP A;  3HPT A;  1UZQ A;  3CFW A;  4YT7 L;  2W3K B;  1F7M A;  2WYG B;  1WU1 B;  3ELA L;  1KIG L;  1DIY A;  2WZP P;  2J34 B;  3N8W B;  4JZF L;  1ZAQ A;  2Y7X B;  1X7A L;  2Y5H L;  5IKV A;  2OYE P;  1FSB A;  2PR3 B;  2XBX L;  3U7U G;  1EQG A;  2NPR A;  3N8Z A;  4NGA L;  1HT5 A;  5JB9 E;  2RA0 L;  1TPG A;  2J4I B;  4NA9 L;  4CSY A;  1YGC L;  4A7I A;  1G1R A;  3Q7D A;  2XC4 L;  3HO4 A;  4XLW A;  5JBA E;  4ZH8 B;  1IQK L;  1YUK B;  2W3I B;  2BQ7 A;  5COX A;  5E8D A;  3OLU A;  1PRH A;  2WPM E;  3P5B L;  1F7E A;  1IQF L;  2W2N E;  4MMX B;  2W2O E;  5JVY A;  1WHF A;  4X8T L;  3QCW A;  3LN0 A;  2VVC K;  3FFG L;  1A3P A;  1L5G B;  1CQE A;  2W86 A;  2P3T A;  4ZHA B;  1NZI A;  3N8W A;  5IKQ A;  1L3Y A;  3KQC L;  2FLR L;  3C9A C;  2P3U A;  3IJE B;  3BT1 A;  1IOE L;  2XBV L;  4D0F A;  2FLG A;  2VWO L;  4BXW A;  1LPK A;  3ENS A;  1JV2 B;  4JZE L;  4JYV L;  5F1A A;  1SZB A;  3N8V A;  5KN5 C;  4Y76 B;  1I0U A;  4Y7A B;  2FLB L;  2WPI E;  1HRF A;  2Y5G L;  2VWL L;  1FJS L;  2ADX A;  5CKQ A;  1IQM L;  1HCG B;  2AYL A;  2J2U B;  3KRK A;  2TGF A;  2BZ6 L;  2WPJ E;  4X8S L;  2J95 B;  4BXS A;  3TZI A;  2WG4 B;  2K2S B;  3TH3 L;  1PXX A;  1F0S B;  1IQI L;  3F1S B;  1UZJ A;  2P3F L;  1EPG A;  2XBW L;  3ZYJ B;  4ISI L;  4Y71 B;  1JL9 A;  2WPK E;  4Y6D B;  1HJ7 A;  1N1I A;  3V65 B;  2VH0 B;  2W2P E;  4RS0 A;  1AUT L;  3EGF A;  3RR3 A;  3CEN L;  2P3F N;  1FAX L;  2D1J B;  2WG3 C;  3NT1 A;  1IQE L;  3KL6 B;  5F19 A;  3GCW E;  1FAK L;  1C5M F;  4Z0K B;  1ATB A;  5IKT A;  2Y82 B;  1U67 A;  3CA7 A;  4BTU A;  1EMN A;  2I9A A;  4LOR A;  4RRY A;  3HS6 A;  1DDX A;  3HS7 A;  1IJQ A;  2P95 L;  1LQD A;  4RUT A;  3BPS E;  4O1Z A;  5L30 L;  1P9J A;  1KLJ L;  3NTG A;  1J9C L;  1O5D L;  1YUF A;  4JYU L;  1KLO A;  3LC3 B;  1CVU A;  1CX2 A;  1WHE A;  3TK5 B;  5K0H B;  1UZP A;  4C16 A;  1XKA L;  1ADX A;  4JZD L;  4Z6A L;  2Y38 A;  3HO5 A;  2KNI A;  2KB9 A;  5FDQ A;  4M11 A;  4D0E A;  1RFN B;  1G1S A;  3KK6 A;  5JBB E;  2YGO A;  2VJ3 A;  2I9B A;  2J38 B;  4D90 A;  2WFX B;  5JVZ A;  2MGR A;  4Y7B B;  2VWN L;  3M36 L;  3H5C B;  2BQ6 A;  4BDX A;  4ISH L;  5EGM B;  1ATA A;  1PTH A;  2FZZ L;  3KQE L;  1IGZ A;  4LMF A;  1NT0 A;  1KLI L;  3S6X A;  3M37 L;  2BMG A;  2Q1J B;  1NPE B;  1Z6C A;  6COX A;  2P26 A;  4RRZ A;  4OTJ A;  1ATD A;  2GD4 A;  3IIT B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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