1C5MF

Structural basis for selectivity of a small molecule, s1-binding, sub-micromolar inhibitor of urokinase type plasminogen activator
Total Genus 7
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
7
sequence length
52
structure length
52
Chain Sequence
LCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLER
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural basis for selectivity of a small molecule, S1-binding, submicromolar inhibitor of urokinase-type plasminogen activator.
pubmed doi rcsb
molecule tags Blood clotting
molecule keywords PROTEIN (COAGULATION FACTOR X)
total genus 7
structure length 52
sequence length 52
ec nomenclature ec 3.4.21.6: Coagulation factor Xa.
pdb deposition date 1999-12-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
F PF00008 EGF EGF-like domain
F PF14670 FXa_inhibition Coagulation Factor Xa inhibitory site
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.25.10 Mainly Beta Ribbon Laminin Laminin 1c5mF00
1ATAA 2VWNL 2VJ3A 4XL1A 2VVUL 4Y7BB 3KCGL 2RNLA 2YGOA 1IGXA 2BQ7A 2W3IB 1IJQA 1CVWL 1XFEA 2AYLA 2VH0B 3N8WB 4Y76B 3ASIA 3KQDL 3LC5B 3ZYGA 3GISX 1PRHA 2P3FL 3QH0A 5IKQA 2VH6B 2Y82B 3LAQA 2Y5HL 1FSBA 2J2UB 5F1AA 5JVZA 1CEJA 1N7DA 1EMNA 1U67A 1IQJL 4MMXB 2Q1JB 4NA9L 1EQHA 1YUGA 1LPGA 3IITB 3IJEB 1GK5A 4CUDA 1APQA 4ZXXL 2EI8B 3GCWE 2XBWL 1NZIA 2G00L 2OYUP 2BQWA 1G2LB 1HRFA 3HS5A 1DQBA 3QCWA 2W2QE 1JL9A 4JZFL 3V64C 1UZJA 5COXA 4LMFA 4E1GA 6COXA 4Y6DB 4FM5A 3N8WA 2I9BA 1UZPA 2FLBL 2KV4A 4YT7L 4ISIL 1OB1C 2K2SB 1XKAL 1MQ5L 5F19A 2BOXA 1XKBA 1WU1B 2Y7XB 1X7AL 1IQKL 1EQGA 2H9EL 3R05A 1L5GB 3SW2A 1UZKA 1ZAQA 2XC5L 1PFXL 3F6UL 5EGMB 4BXSA 4YZUB 1JV2B 1N1IA 1W7XL 2W86A 3KK6A 2JKHL 4D0EA 3HS6A 4D90A 3QMOA 3NJPC 1IQHL 3BPSE 2Y5GL 2XC0L 1PXXA 4ZH8B 1FF7A 2W2NE 4NGAL 3HPTA 2NPRA 1HREA 5JBAE 2BQ6A 1F0RB 1JBUL 2XC4L 4X8SL 3C9AC 1MQ6L 3POYA 1WHFA 3MDLA 2XBXL 1ADXA 2BOKL 2BO2A 4A7IA 2CJIB 1Z6CA 3KQEL 1EMOA 4XLWA 3Q3KB 4RRYA 3N8YB 2UWOB 2Y81B 5JVYA 1HCGB 2BOUA 3U73A 5JB9E 3M36L 4LORA 3KL6B 3HO3A 5CKNA 1G1SA 1HT5A 2W2ME 5JW1A 2WFTA 2PUQL 4RS0A 1KLJL 1P0SL 4ZAEB 2EI6B 1ATEA 4MMZB 2MGRA 2RA0L 3PGHA 3DEMA 2J94B 4X8UL 4O1ZA 3FCSB 2W3KB 1J9CL 1M1XB 3Q7DA 1IQLL 1G2MB 3NT1A 3P5BL 1HZ8A 3BT2A 4JYUL 4BTIA 1LQDA 3CFWA 3SOVA 5L2ZL 3CA7A 2WPJE 2UWPB 1PTHA 4M11A 5JBBE 1IOEL 3HS7A 3OLTA 2J34B 5K0HB 3N8YA 1IOXA 4NG9L 3LIWB 1DX5I 1EBVA 2Y5FL 2VWMK 3RR3A 1IGZA 2M74A 5JBCE 3SOQA 3ELAL 2P93L 1KLOA 3CS7L 4Z6AL 4Y7AB 1KLIL 1W8BL 1YO8A 1HT8A 1Z6EL 4X8VL 1IVOC 3U7UG 2P94L 3H5CB 3LTGD 1HX2A 4AQTA 3ENSA 2KL7A 2VWLL 2MHPA 1NT0A 2P3FN 2WPIE 3TK6B 2J95B 1EAIC 2P95L 1A3PA 1EPGA 2Y38A 2Y7ZB 1P9JA 3LN1A 1EPJA 1HJ7A 4JZDL 2D1JB 3NTGA 4ZXYL 2J38B 3TZIA 3HO5A 1ATDA 3N8VA 4Y79B 3TK5B 2P3UA 1Q4GA 2GD4A 1B9WA 4OTYA 3OLUA 1I0UA 1IQGL 1G1QA 1DDXA 1NFYB 2WG4B 2VVCK 1F7MA 1G1TA 2W26B 3LC3B 5KIRA 3N8ZA 3TGFA 2XBVL 3ZYJB 5IKTA 1EPHA 5JB8E 2BZ6L 1IQFL 1FAXL 2WYJB 2PHBB 2W2PE 5L30L 1U8CB 2WPKE 4XBMA 3GCXE 3LTFB 2WFXB 2DDUA 2P3TA 1TOZA 1UZQA 1IQIL 1F0SB 5IKVA 1DVAL 2FZZL 1SZBA 1URKA 1CX2A 3F1SB 3LN0A 2BOHA 4D0FA 5E8DA 1TPGA 4JYVL 4M10A 1COUA 4CUFA 2WPME 2F9BL 3KQCL 2FD6A 1NFXB 4RUTA 4ZHAB 1HAFA 2BMGA 2FLRL 1WHEA 2WPHE 1L3YA 2KB9A 3KQBL 1CCFA 4X8TL 2EI7B 1NFUB 4JZEL 4PH9A 4BTTA 5L2YL 1YUFA 2OYEP 4TGFA 1IQEL 4O02B 4RRZA 4BDWA 4ISHL 3V65B 5IKRA 3FBYA 4Z0KB 1BF9A 2P16L 1DIYA 3TBDA 3NTBA 2I9AA 1G1RA 5KN5C 4Z0LA 3CENL 2WPLE 1LMJA 2RHPA 1XDTR 1K37A 2UWLB 2ADXA 1IP0A 1V3XB 3FFGL 1O5DL 4MMYB 2J4IB 4RRWA 4YT6L 4Y71B 1CVUA 3BT1A 3ZYIB 5CKQA 1K36A 2TGFA 4CUEA 3N8XA 5I46L 1QFKL 5CISA 4COXA 1CQEA 2K2TA 1KIGL 1HAEA 3TH3L 1NQLB 2P26A 5CKMA 1EGFA 1NFWB 1RFNB 3K9XA 4BTUA 1PGEA 2FLGA 1IQNL 2XBYL 2VVVL 1FJSL 2B7DL 1NPEB 1CCVA 1EZQB 2Y80B 1YGCL 1TLEA 3HO4A 1LPKA 4OTJA 1IQML 2WG3C 1APOA 1EPIA 2MGPA 1MOXC 1F7EA 4BDXA 1C5MF 4CSYA 3EGFA 2W2OE 1LPZA 2PR3B 4BXWA 1YUKB 1ATBA 3M37L 2VWOL 1FE2A 4G1MB 1KSNB 3KRKA 4RRXA 2YGPA 5FDQA 2P28B 1FFMA 4C16A 1FAKL 1AUTL 3MQEA 3SOBB 2WYGB
chains in the Genus database with same CATH superfamily
1ATAA 2VWNL 2VJ3A 4XL1A 2VVUL 4Y7BB 3KCGL 2RNLA 2YGOA 1IGXA 2BQ7A 2W3IB 1IJQA 1CVWL 1XFEA 2AYLA 2VH0B 3N8WB 4Y76B 3ASIA 3KQDL 3LC5B 3ZYGA 3GISX 1PRHA 2P3FL 3QH0A 5IKQA 2VH6B 2Y82B 3LAQA 2Y5HL 1FSBA 2J2UB 5F1AA 5JVZA 1CEJA 1N7DA 1EMNA 1U67A 1IQJL 4MMXB 2Q1JB 4NA9L 1EQHA 1YUGA 1LPGA 3IITB 3IJEB 1GK5A 4CUDA 1APQA 4ZXXL 2EI8B 3GCWE 2XBWL 1NZIA 2G00L 2OYUP 2BQWA 1G2LB 1HRFA 3HS5A 1DQBA 3QCWA 2W2QE 1JL9A 4JZFL 3V64C 1UZJA 5COXA 4LMFA 4E1GA 6COXA 4Y6DB 4FM5A 3N8WA 2I9BA 1UZPA 2FLBL 2KV4A 4YT7L 4ISIL 1OB1C 2K2SB 1XKAL 1MQ5L 5F19A 2BOXA 1XKBA 1WU1B 2Y7XB 4A94C 1X7AL 1IQKL 1EQGA 2H9EL 3R05A 1L5GB 3SW2A 1UZKA 1ZAQA 2BT8A 2XC5L 1PFXL 2KNIA 3F6UL 5EGMB 4BXSA 4YZUB 1JV2B 1N1IA 1W7XL 2W86A 3KK6A 2JKHL 4D0EA 2HORA 3HS6A 4D90A 3QMOA 3NJPC 1IQHL 3BPSE 2Y5GL 2XC0L 1PXXA 4ZH8B 1FF7A 2W2NE 4NGAL 3HPTA 2NPRA 1HREA 5JBAE 2BQ6A 1F0RB 1JBUL 2XC4L 4X8SL 4GU4A 3C9AC 1MQ6L 3POYA 1WHFA 3MDLA 2XBXL 1ADXA 2BOKL 2BO2A 4A7IA 2CJIB 1Z6CA 3KQEL 1EMOA 4XLWA 3Q3KB 4RRYA 3N8YB 2UWOB 2Y81B 5JVYA 1HCGB 2BOUA 3U73A 5JB9E 3M36L 4LORA 3KL6B 3HO3A 5CKNA 1G1SA 1HT5A 2W2ME 5JW1A 2WFTA 2PUQL 4RS0A 1KLJL 1P0SL 4ZAEB 2EI6B 1ATEA 4MMZB 2MGRA 2RA0L 3PGHA 3DEMA 2J94B 4X8UL 4O1ZA 3FCSB 2W3KB 1J9CL 1M1XB 3Q7DA 1IQLL 1G2MB 3NT1A 3P5BL 1HZ8A 3BT2A 4JYUL 4BTIA 1LQDA 3CFWA 3SOVA 5L2ZL 3CA7A 2WPJE 2UWPB 1PTHA 4M11A 5JBBE 1IOEL 3HS7A 3OLTA 2J34B 5K0HB 3N8YA 1IOXA 4NG9L 3LIWB 1DX5I 1EBVA 2Y5FL 2VWMK 3RR3A 1IGZA 2M74A 5JBCE 3SOQA 3ELAL 2P93L 1KLOA 3CS7L 4Z6AL 4Y7AB 1KLIL 1W8BL 1YO8A 1HT8A 2YGQA 1Z6EL 4X8VL 1IVOC 1KKEA 3U7UG 2P94L 3H5CB 3LTGD 1HX2A 4AQTA 3ENSA 2KL7A 2VWLL 2MHPA 1NT0A 2P3FN 2WPIE 3TK6B 2J95B 1EAIC 2P95L 1A3PA 1EPGA 2Y38A 2Y7ZB 1P9JA 3LN1A 1EPJA 1HJ7A 4JZDL 2D1JB 2JJLA 3NTGA 4ZXYL 2J38B 3TZIA 3HO5A 1ATDA 3N8VA 4Y79B 3TK5B 2P3UA 1Q4GA 2GD4A 1B9WA 4OTYA 3OLUA 1I0UA 1IQGL 1G1QA 1DDXA 1NFYB 2WG4B 2BT7A 2VVCK 1F7MA 1G1TA 2W26B 3LC3B 5KIRA 3N8ZA 3TGFA 2XBVL 3ZYJB 5IKTA 1EPHA 5JB8E 2BZ6L 1IQFL 1FAXL 2WYJB 2PHBB 2W2PE 5L30L 1U8CB 2WPKE 2HOXA 4XBMA 3GCXE 3LTFB 2WFXB 2DDUA 2P3TA 1TOZA 1UZQA 1IQIL 1F0SB 5IKVA 1DVAL 2FZZL 1SZBA 1URKA 1CX2A 3F1SB 3LN0A 2BOHA 4D0FA 5E8DA 1TPGA 4JYVL 4M10A 1COUA 4CUFA 2WPME 2F9BL 3KQCL 2FD6A 4GU3A 1NFXB 4RUTA 4ZHAB 1HAFA 2BMGA 1LK9A 2FLRL 1WHEA 2WPHE 1L3YA 2KB9A 3KQBL 1CCFA 4X8TL 2EI7B 1NFUB 4JZEL 4PH9A 4BTTA 5L2YL 1YUFA 2OYEP 4TGFA 1IQEL 1V1IA 4O02B 4RRZA 4ISHL 4BDWA 3V65B 5IKRA 3FBYA 4Z0KB 1BF9A 1QIUA 2P16L 1DIYA 3TBDA 3NTBA 2WZPP 2I9AA 1G1RA 5KN5C 4Z0LA 3CENL 2WPLE 1LMJA 2RHPA 1XDTR 1K37A 2UWLB 2ADXA 1IP0A 1V3XB 3FFGL 1O5DL 4MMYB 2J4IB 4RRWA 1V1HA 4YT6L 4Y71B 1CVUA 3BT1A 3ZYIB 5CKQA 1K36A 2TGFA 4CUEA 3N8XA 5I46L 1QFKL 5CISA 4COXA 1CQEA 2K2TA 1KIGL 1HAEA 3TH3L 1NQLB 2P26A 5CKMA 2H9EC 1EGFA 1NFWB 1RFNB 3K9XA 4BTUA 1PGEA 2FLGA 1IQNL 2XBYL 2VVVL 1FJSL 2B7DL 1NPEB 1CCVA 1EZQB 3S6XA 2Y80B 1YGCL 1TLEA 3HO4A 1LPKA 4OTJA 1IQML 2WG3C 1APOA 1EPIA 2MGPA 1MOXC 1F7EA 4BDXA 1C5MF 4CSYA 3EGFA 2W2OE 1LPZA 2PR3B 4BXWA 1YUKB 1ATBA 3M37L 2VWOL 1FE2A 1LMMA 1KSNB 3KRKA 4G1MB 4RRXA 2YGPA 5FDQA 2BSFA 2P28B 1FFMA 4C16A 2VRSA 1FAKL 1AUTL 3MQEA 3SOBB 2WYGB
chains in the Genus database with same CATH topology
1ATAA 2VWNL 2VJ3A 4XL1A 2VVUL 4Y7BB 3KCGL 2RNLA 2YGOA 1IGXA 2BQ7A 2W3IB 1IJQA 1CVWL 1XFEA 2AYLA 2VH0B 3N8WB 4Y76B 3ASIA 3KQDL 3LC5B 3ZYGA 3GISX 1PRHA 2P3FL 3QH0A 5IKQA 2VH6B 2Y82B 3LAQA 2Y5HL 1FSBA 2J2UB 5F1AA 5JVZA 1CEJA 1N7DA 1EMNA 1U67A 1IQJL 4MMXB 2Q1JB 4NA9L 1EQHA 1YUGA 1LPGA 3IITB 3IJEB 1GK5A 4CUDA 1APQA 4ZXXL 2EI8B 3GCWE 2XBWL 1NZIA 2G00L 2OYUP 2BQWA 1G2LB 1HRFA 3HS5A 1DQBA 3QCWA 2W2QE 1JL9A 4JZFL 3V64C 1UZJA 5COXA 4LMFA 4E1GA 6COXA 4Y6DB 4FM5A 3N8WA 2I9BA 1UZPA 2FLBL 2KV4A 4YT7L 4ISIL 1OB1C 2K2SB 1XKAL 1MQ5L 5F19A 2BOXA 1XKBA 1WU1B 2Y7XB 4A94C 1X7AL 1IQKL 1EQGA 2H9EL 3R05A 1L5GB 3SW2A 1UZKA 1ZAQA 2XC5L 1PFXL 2KNIA 3F6UL 5EGMB 4BXSA 4YZUB 1JV2B 1N1IA 1W7XL 2W86A 3KK6A 2JKHL 4D0EA 3HS6A 4D90A 3QMOA 3NJPC 1IQHL 3BPSE 2Y5GL 2XC0L 1PXXA 4ZH8B 1FF7A 2W2NE 4NGAL 3HPTA 2NPRA 1HREA 5JBAE 2BQ6A 1F0RB 1JBUL 2XC4L 4X8SL 3C9AC 1MQ6L 3POYA 1WHFA 3MDLA 2XBXL 1ADXA 2BOKL 2BO2A 4A7IA 2CJIB 1Z6CA 3KQEL 1EMOA 4XLWA 3Q3KB 4RRYA 3N8YB 2UWOB 2Y81B 5JVYA 1HCGB 2BOUA 3U73A 5JB9E 3M36L 4LORA 3KL6B 3HO3A 5CKNA 1G1SA 1HT5A 2W2ME 5JW1A 2WFTA 2PUQL 4RS0A 1KLJL 1P0SL 4ZAEB 2EI6B 1ATEA 4MMZB 2MGRA 2RA0L 3PGHA 3DEMA 2J94B 4X8UL 4O1ZA 3FCSB 2W3KB 1J9CL 1M1XB 3Q7DA 1IQLL 1G2MB 3NT1A 3P5BL 1HZ8A 3BT2A 4JYUL 4BTIA 1LQDA 3CFWA 3SOVA 5L2ZL 3CA7A 2WPJE 2UWPB 1PTHA 4M11A 5JBBE 1IOEL 3HS7A 3OLTA 2J34B 5K0HB 3N8YA 1IOXA 4NG9L 3LIWB 1DX5I 1EBVA 2Y5FL 2VWMK 3RR3A 1IGZA 2M74A 5JBCE 3SOQA 3ELAL 2P93L 1KLOA 3CS7L 4Z6AL 4Y7AB 1KLIL 1W8BL 1YO8A 1HT8A 2YGQA 1Z6EL 4X8VL 1IVOC 3U7UG 2P94L 3H5CB 3LTGD 1HX2A 4AQTA 3ENSA 2KL7A 2VWLL 2MHPA 1NT0A 2P3FN 2WPIE 3TK6B 2J95B 1EAIC 2P95L 1A3PA 1EPGA 2Y38A 2Y7ZB 1P9JA 3LN1A 1EPJA 1HJ7A 4JZDL 2D1JB 3NTGA 4ZXYL 2J38B 3TZIA 3HO5A 1ATDA 3N8VA 4Y79B 3TK5B 2P3UA 1Q4GA 2GD4A 1B9WA 4OTYA 3OLUA 1I0UA 1IQGL 1G1QA 1DDXA 1NFYB 2WG4B 2VVCK 1F7MA 1G1TA 2W26B 3LC3B 5KIRA 3N8ZA 3TGFA 2XBVL 3ZYJB 5IKTA 1EPHA 5JB8E 2BZ6L 1IQFL 1FAXL 2WYJB 2PHBB 2W2PE 5L30L 1U8CB 2WPKE 4XBMA 3GCXE 3LTFB 2WFXB 2DDUA 2P3TA 1TOZA 1UZQA 1IQIL 1F0SB 5IKVA 1DVAL 2FZZL 1SZBA 1URKA 1CX2A 3F1SB 3LN0A 2BOHA 4D0FA 5E8DA 1TPGA 4JYVL 4M10A 1COUA 4CUFA 2WPME 2F9BL 3KQCL 2FD6A 1NFXB 4RUTA 4ZHAB 1HAFA 2BMGA 2FLRL 1WHEA 2WPHE 1L3YA 2KB9A 3KQBL 1CCFA 4X8TL 2EI7B 1NFUB 4JZEL 4PH9A 4BTTA 5L2YL 1YUFA 2OYEP 4TGFA 1IQEL 4O02B 4RRZA 4BDWA 4ISHL 3V65B 5IKRA 3FBYA 4Z0KB 1BF9A 2P16L 1DIYA 3TBDA 3NTBA 2WZPP 2I9AA 1G1RA 5KN5C 4Z0LA 3CENL 2WPLE 1LMJA 2RHPA 1XDTR 1K37A 2UWLB 2ADXA 1IP0A 1V3XB 3FFGL 1O5DL 4MMYB 2J4IB 4RRWA 4YT6L 4Y71B 1CVUA 3BT1A 3ZYIB 5CKQA 1K36A 2TGFA 4CUEA 3N8XA 5I46L 1QFKL 5CISA 4COXA 1CQEA 2K2TA 1KIGL 1HAEA 3TH3L 1NQLB 2P26A 5CKMA 2H9EC 1EGFA 1NFWB 1RFNB 3K9XA 4BTUA 1PGEA 2FLGA 1IQNL 2XBYL 2VVVL 1FJSL 2B7DL 1NPEB 1CCVA 1EZQB 3S6XA 2Y80B 1YGCL 1TLEA 3HO4A 1LPKA 4OTJA 1IQML 2WG3C 1APOA 1EPIA 2MGPA 1MOXC 1F7EA 4BDXA 1C5MF 4CSYA 3EGFA 2W2OE 1LPZA 2PR3B 4BXWA 1YUKB 1ATBA 3M37L 2VWOL 1FE2A 1LMMA 1KSNB 3KRKA 4G1MB 4RRXA 2YGPA 5FDQA 2P28B 1FFMA 4C16A 1FAKL 1AUTL 3MQEA 3SOBB 2WYGB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1ATA A;  2VWN L;  2VJ3 A;  4XL1 A;  2VVU L;  4Y7B B;  3KCG L;  2RNL A;  2YGO A;  1IGX A;  2BQ7 A;  2W3I B;  1IJQ A;  1CVW L;  1XFE A;  2AYL A;  2VH0 B;  3N8W B;  4Y76 B;  3ASI A;  3KQD L;  3LC5 B;  3ZYG A;  3GIS X;  1PRH A;  2P3F L;  3QH0 A;  5IKQ A;  2VH6 B;  2Y82 B;  3LAQ A;  2Y5H L;  1FSB A;  2J2U B;  5F1A A;  5JVZ A;  1CEJ A;  1N7D A;  1EMN A;  1U67 A;  1IQJ L;  4MMX B;  2Q1J B;  4NA9 L;  1EQH A;  1YUG A;  1LPG A;  3IIT B;  3IJE B;  1GK5 A;  4CUD A;  1APQ A;  4ZXX L;  2EI8 B;  3GCW E;  2XBW L;  1NZI A;  2G00 L;  2OYU P;  2BQW A;  1G2L B;  1HRF A;  3HS5 A;  1DQB A;  3QCW A;  2W2Q E;  1JL9 A;  4JZF L;  3V64 C;  1UZJ A;  5COX A;  4LMF A;  4E1G A;  6COX A;  4Y6D B;  4FM5 A;  3N8W A;  2I9B A;  1UZP A;  2FLB L;  2KV4 A;  4YT7 L;  4ISI L;  1OB1 C;  2K2S B;  1XKA L;  1MQ5 L;  5F19 A;  2BOX A;  1XKB A;  1WU1 B;  2Y7X B;  1X7A L;  1IQK L;  1EQG A;  2H9E L;  3R05 A;  1L5G B;  3SW2 A;  1UZK A;  1ZAQ A;  2XC5 L;  1PFX L;  3F6U L;  5EGM B;  4BXS A;  4YZU B;  1JV2 B;  1N1I A;  1W7X L;  2W86 A;  3KK6 A;  2JKH L;  4D0E A;  3HS6 A;  4D90 A;  3QMO A;  3NJP C;  1IQH L;  3BPS E;  2Y5G L;  2XC0 L;  1PXX A;  4ZH8 B;  1FF7 A;  2W2N E;  4NGA L;  3HPT A;  2NPR A;  1HRE A;  5JBA E;  2BQ6 A;  1F0R B;  1JBU L;  2XC4 L;  4X8S L;  3C9A C;  1MQ6 L;  3POY A;  1WHF A;  3MDL A;  2XBX L;  1ADX A;  2BOK L;  2BO2 A;  4A7I A;  2CJI B;  1Z6C A;  3KQE L;  1EMO A;  4XLW A;  3Q3K B;  4RRY A;  3N8Y B;  2UWO B;  2Y81 B;  5JVY A;  1HCG B;  2BOU A;  3U73 A;  5JB9 E;  3M36 L;  4LOR A;  3KL6 B;  3HO3 A;  5CKN A;  1G1S A;  1HT5 A;  2W2M E;  5JW1 A;  2WFT A;  2PUQ L;  4RS0 A;  1KLJ L;  1P0S L;  4ZAE B;  2EI6 B;  1ATE A;  4MMZ B;  2MGR A;  2RA0 L;  3PGH A;  3DEM A;  2J94 B;  4X8U L;  4O1Z A;  3FCS B;  2W3K B;  1J9C L;  1M1X B;  3Q7D A;  1IQL L;  1G2M B;  3NT1 A;  3P5B L;  1HZ8 A;  3BT2 A;  4JYU L;  4BTI A;  1LQD A;  3CFW A;  3SOV A;  5L2Z L;  3CA7 A;  2WPJ E;  2UWP B;  1PTH A;  4M11 A;  5JBB E;  1IOE L;  3HS7 A;  3OLT A;  2J34 B;  5K0H B;  3N8Y A;  1IOX A;  4NG9 L;  3LIW B;  1DX5 I;  1EBV A;  2Y5F L;  2VWM K;  3RR3 A;  1IGZ A;  2M74 A;  5JBC E;  3SOQ A;  3ELA L;  2P93 L;  1KLO A;  3CS7 L;  4Z6A L;  4Y7A B;  1KLI L;  1W8B L;  1YO8 A;  1HT8 A;  1Z6E L;  4X8V L;  1IVO C;  3U7U G;  2P94 L;  3H5C B;  3LTG D;  1HX2 A;  4AQT A;  3ENS A;  2KL7 A;  2VWL L;  2MHP A;  1NT0 A;  2P3F N;  2WPI E;  3TK6 B;  2J95 B;  1EAI C;  2P95 L;  1A3P A;  1EPG A;  2Y38 A;  2Y7Z B;  1P9J A;  3LN1 A;  1EPJ A;  1HJ7 A;  4JZD L;  2D1J B;  3NTG A;  4ZXY L;  2J38 B;  3TZI A;  3HO5 A;  1ATD A;  3N8V A;  4Y79 B;  3TK5 B;  2P3U A;  1Q4G A;  2GD4 A;  1B9W A;  4OTY A;  3OLU A;  1I0U A;  1IQG L;  1G1Q A;  1DDX A;  1NFY B;  2WG4 B;  2VVC K;  1F7M A;  1G1T A;  2W26 B;  3LC3 B;  5KIR A;  3N8Z A;  3TGF A;  2XBV L;  3ZYJ B;  5IKT A;  1EPH A;  5JB8 E;  2BZ6 L;  1IQF L;  1FAX L;  2WYJ B;  2PHB B;  2W2P E;  5L30 L;  1U8C B;  2WPK E;  4XBM A;  3GCX E;  3LTF B;  2WFX B;  2DDU A;  2P3T A;  1TOZ A;  1UZQ A;  1IQI L;  1F0S B;  5IKV A;  1DVA L;  2FZZ L;  1SZB A;  1URK A;  1CX2 A;  3F1S B;  3LN0 A;  2BOH A;  4D0F A;  5E8D A;  1TPG A;  4JYV L;  4M10 A;  1COU A;  4CUF A;  2WPM E;  2F9B L;  3KQC L;  2FD6 A;  1NFX B;  4RUT A;  4ZHA B;  1HAF A;  2BMG A;  2FLR L;  1WHE A;  2WPH E;  1L3Y A;  2KB9 A;  3KQB L;  1CCF A;  4X8T L;  2EI7 B;  1NFU B;  4JZE L;  4PH9 A;  4BTT A;  5L2Y L;  1YUF A;  2OYE P;  4TGF A;  1IQE L;  4O02 B;  4RRZ A;  4BDW A;  4ISH L;  3V65 B;  5IKR A;  3FBY A;  4Z0K B;  1BF9 A;  2P16 L;  1DIY A;  3TBD A;  3NTB A;  2I9A A;  1G1R A;  5KN5 C;  4Z0L A;  3CEN L;  2WPL E;  1LMJ A;  2RHP A;  1XDT R;  1K37 A;  2UWL B;  2ADX A;  1IP0 A;  1V3X B;  3FFG L;  1O5D L;  4MMY B;  2J4I B;  4RRW A;  4YT6 L;  4Y71 B;  1CVU A;  3BT1 A;  3ZYI B;  5CKQ A;  1K36 A;  2TGF A;  4CUE A;  3N8X A;  5I46 L;  1QFK L;  5CIS A;  4COX A;  1CQE A;  2K2T A;  1KIG L;  1HAE A;  3TH3 L;  1NQL B;  2P26 A;  5CKM A;  1EGF A;  1NFW B;  1RFN B;  3K9X A;  4BTU A;  1PGE A;  2FLG A;  1IQN L;  2XBY L;  2VVV L;  1FJS L;  2B7D L;  1NPE B;  1CCV A;  1EZQ B;  2Y80 B;  1YGC L;  1TLE A;  3HO4 A;  1LPK A;  4OTJ A;  1IQM L;  2WG3 C;  1APO A;  1EPI A;  2MGP A;  1MOX C;  1F7E A;  4BDX A;  1C5M F;  4CSY A;  3EGF A;  2W2O E;  1LPZ A;  2PR3 B;  4BXW A;  1YUK B;  1ATB A;  3M37 L;  2VWO L;  1FE2 A;  4G1M B;  1KSN B;  3KRK A;  4RRX A;  2YGP A;  5FDQ A;  2P28 B;  1FFM A;  4C16 A;  1FAK L;  1AUT L;  3MQE A;  3SOB B;  2WYG B; 
#chains in the Genus database with same CATH topology
 1ATA A;  2VWN L;  2VJ3 A;  4XL1 A;  2VVU L;  4Y7B B;  3KCG L;  2RNL A;  2YGO A;  1IGX A;  2BQ7 A;  2W3I B;  1IJQ A;  1CVW L;  1XFE A;  2AYL A;  2VH0 B;  3N8W B;  4Y76 B;  3ASI A;  3KQD L;  3LC5 B;  3ZYG A;  3GIS X;  1PRH A;  2P3F L;  3QH0 A;  5IKQ A;  2VH6 B;  2Y82 B;  3LAQ A;  2Y5H L;  1FSB A;  2J2U B;  5F1A A;  5JVZ A;  1CEJ A;  1N7D A;  1EMN A;  1U67 A;  1IQJ L;  4MMX B;  2Q1J B;  4NA9 L;  1EQH A;  1YUG A;  1LPG A;  3IIT B;  3IJE B;  1GK5 A;  4CUD A;  1APQ A;  4ZXX L;  2EI8 B;  3GCW E;  2XBW L;  1NZI A;  2G00 L;  2OYU P;  2BQW A;  1G2L B;  1HRF A;  3HS5 A;  1DQB A;  3QCW A;  2W2Q E;  1JL9 A;  4JZF L;  3V64 C;  1UZJ A;  5COX A;  4LMF A;  4E1G A;  6COX A;  4Y6D B;  4FM5 A;  3N8W A;  2I9B A;  1UZP A;  2FLB L;  2KV4 A;  4YT7 L;  4ISI L;  1OB1 C;  2K2S B;  1XKA L;  1MQ5 L;  5F19 A;  2BOX A;  1XKB A;  1WU1 B;  2Y7X B;  4A94 C;  1X7A L;  1IQK L;  1EQG A;  2H9E L;  3R05 A;  1L5G B;  3SW2 A;  1UZK A;  1ZAQ A;  2BT8 A;  2XC5 L;  1PFX L;  2KNI A;  3F6U L;  5EGM B;  4BXS A;  4YZU B;  1JV2 B;  1N1I A;  1W7X L;  2W86 A;  3KK6 A;  2JKH L;  4D0E A;  2HOR A;  3HS6 A;  4D90 A;  3QMO A;  3NJP C;  1IQH L;  3BPS E;  2Y5G L;  2XC0 L;  1PXX A;  4ZH8 B;  1FF7 A;  2W2N E;  4NGA L;  3HPT A;  2NPR A;  1HRE A;  5JBA E;  2BQ6 A;  1F0R B;  1JBU L;  2XC4 L;  4X8S L;  4GU4 A;  3C9A C;  1MQ6 L;  3POY A;  1WHF A;  3MDL A;  2XBX L;  1ADX A;  2BOK L;  2BO2 A;  4A7I A;  2CJI B;  1Z6C A;  3KQE L;  1EMO A;  4XLW A;  3Q3K B;  4RRY A;  3N8Y B;  2UWO B;  2Y81 B;  5JVY A;  1HCG B;  2BOU A;  3U73 A;  5JB9 E;  3M36 L;  4LOR A;  3KL6 B;  3HO3 A;  5CKN A;  1G1S A;  1HT5 A;  2W2M E;  5JW1 A;  2WFT A;  2PUQ L;  4RS0 A;  1KLJ L;  1P0S L;  4ZAE B;  2EI6 B;  1ATE A;  4MMZ B;  2MGR A;  2RA0 L;  3PGH A;  3DEM A;  2J94 B;  4X8U L;  4O1Z A;  3FCS B;  2W3K B;  1J9C L;  1M1X B;  3Q7D A;  1IQL L;  1G2M B;  3NT1 A;  3P5B L;  1HZ8 A;  3BT2 A;  4JYU L;  4BTI A;  1LQD A;  3CFW A;  3SOV A;  5L2Z L;  3CA7 A;  2WPJ E;  2UWP B;  1PTH A;  4M11 A;  5JBB E;  1IOE L;  3HS7 A;  3OLT A;  2J34 B;  5K0H B;  3N8Y A;  1IOX A;  4NG9 L;  3LIW B;  1DX5 I;  1EBV A;  2Y5F L;  2VWM K;  3RR3 A;  1IGZ A;  2M74 A;  5JBC E;  3SOQ A;  3ELA L;  2P93 L;  1KLO A;  3CS7 L;  4Z6A L;  4Y7A B;  1KLI L;  1W8B L;  1YO8 A;  1HT8 A;  2YGQ A;  1Z6E L;  4X8V L;  1IVO C;  1KKE A;  3U7U G;  2P94 L;  3H5C B;  3LTG D;  1HX2 A;  4AQT A;  3ENS A;  2KL7 A;  2VWL L;  2MHP A;  1NT0 A;  2P3F N;  2WPI E;  3TK6 B;  2J95 B;  1EAI C;  2P95 L;  1A3P A;  1EPG A;  2Y38 A;  2Y7Z B;  1P9J A;  3LN1 A;  1EPJ A;  1HJ7 A;  4JZD L;  2D1J B;  2JJL A;  3NTG A;  4ZXY L;  2J38 B;  3TZI A;  3HO5 A;  1ATD A;  3N8V A;  4Y79 B;  3TK5 B;  2P3U A;  1Q4G A;  2GD4 A;  1B9W A;  4OTY A;  3OLU A;  1I0U A;  1IQG L;  1G1Q A;  1DDX A;  1NFY B;  2WG4 B;  2BT7 A;  2VVC K;  1F7M A;  1G1T A;  2W26 B;  3LC3 B;  5KIR A;  3N8Z A;  3TGF A;  2XBV L;  3ZYJ B;  5IKT A;  1EPH A;  5JB8 E;  2BZ6 L;  1IQF L;  1FAX L;  2WYJ B;  2PHB B;  2W2P E;  5L30 L;  1U8C B;  2WPK E;  2HOX A;  4XBM A;  3GCX E;  3LTF B;  2WFX B;  2DDU A;  2P3T A;  1TOZ A;  1UZQ A;  1IQI L;  1F0S B;  5IKV A;  1DVA L;  2FZZ L;  1SZB A;  1URK A;  1CX2 A;  3F1S B;  3LN0 A;  2BOH A;  4D0F A;  5E8D A;  1TPG A;  4JYV L;  4M10 A;  1COU A;  4CUF A;  2WPM E;  2F9B L;  3KQC L;  2FD6 A;  4GU3 A;  1NFX B;  4RUT A;  4ZHA B;  1HAF A;  2BMG A;  1LK9 A;  2FLR L;  1WHE A;  2WPH E;  1L3Y A;  2KB9 A;  3KQB L;  1CCF A;  4X8T L;  2EI7 B;  1NFU B;  4JZE L;  4PH9 A;  4BTT A;  5L2Y L;  1YUF A;  2OYE P;  4TGF A;  1IQE L;  1V1I A;  4O02 B;  4RRZ A;  4ISH L;  4BDW A;  3V65 B;  5IKR A;  3FBY A;  4Z0K B;  1BF9 A;  1QIU A;  2P16 L;  1DIY A;  3TBD A;  3NTB A;  2WZP P;  2I9A A;  1G1R A;  5KN5 C;  4Z0L A;  3CEN L;  2WPL E;  1LMJ A;  2RHP A;  1XDT R;  1K37 A;  2UWL B;  2ADX A;  1IP0 A;  1V3X B;  3FFG L;  1O5D L;  4MMY B;  2J4I B;  4RRW A;  1V1H A;  4YT6 L;  4Y71 B;  1CVU A;  3BT1 A;  3ZYI B;  5CKQ A;  1K36 A;  2TGF A;  4CUE A;  3N8X A;  5I46 L;  1QFK L;  5CIS A;  4COX A;  1CQE A;  2K2T A;  1KIG L;  1HAE A;  3TH3 L;  1NQL B;  2P26 A;  5CKM A;  2H9E C;  1EGF A;  1NFW B;  1RFN B;  3K9X A;  4BTU A;  1PGE A;  2FLG A;  1IQN L;  2XBY L;  2VVV L;  1FJS L;  2B7D L;  1NPE B;  1CCV A;  1EZQ B;  3S6X A;  2Y80 B;  1YGC L;  1TLE A;  3HO4 A;  1LPK A;  4OTJ A;  1IQM L;  2WG3 C;  1APO A;  1EPI A;  2MGP A;  1MOX C;  1F7E A;  4BDX A;  1C5M F;  4CSY A;  3EGF A;  2W2O E;  1LPZ A;  2PR3 B;  4BXW A;  1YUK B;  1ATB A;  3M37 L;  2VWO L;  1FE2 A;  1LMM A;  1KSN B;  3KRK A;  4G1M B;  4RRX A;  2YGP A;  5FDQ A;  2BSF A;  2P28 B;  1FFM A;  4C16 A;  2VRS A;  1FAK L;  1AUT L;  3MQE A;  3SOB B;  2WYG B; 
#chains in the Genus database with same CATH homology
 1ATA A;  2VWN L;  2VJ3 A;  4XL1 A;  2VVU L;  4Y7B B;  3KCG L;  2RNL A;  2YGO A;  1IGX A;  2BQ7 A;  2W3I B;  1IJQ A;  1CVW L;  1XFE A;  2AYL A;  2VH0 B;  3N8W B;  4Y76 B;  3ASI A;  3KQD L;  3LC5 B;  3ZYG A;  3GIS X;  1PRH A;  2P3F L;  3QH0 A;  5IKQ A;  2VH6 B;  2Y82 B;  3LAQ A;  2Y5H L;  1FSB A;  2J2U B;  5F1A A;  5JVZ A;  1CEJ A;  1N7D A;  1EMN A;  1U67 A;  1IQJ L;  4MMX B;  2Q1J B;  4NA9 L;  1EQH A;  1YUG A;  1LPG A;  3IIT B;  3IJE B;  1GK5 A;  4CUD A;  1APQ A;  4ZXX L;  2EI8 B;  3GCW E;  2XBW L;  1NZI A;  2G00 L;  2OYU P;  2BQW A;  1G2L B;  1HRF A;  3HS5 A;  1DQB A;  3QCW A;  2W2Q E;  1JL9 A;  4JZF L;  3V64 C;  1UZJ A;  5COX A;  4LMF A;  4E1G A;  6COX A;  4Y6D B;  4FM5 A;  3N8W A;  2I9B A;  1UZP A;  2FLB L;  2KV4 A;  4YT7 L;  4ISI L;  1OB1 C;  2K2S B;  1XKA L;  1MQ5 L;  5F19 A;  2BOX A;  1XKB A;  1WU1 B;  2Y7X B;  4A94 C;  1X7A L;  1IQK L;  1EQG A;  2H9E L;  3R05 A;  1L5G B;  3SW2 A;  1UZK A;  1ZAQ A;  2XC5 L;  1PFX L;  2KNI A;  3F6U L;  5EGM B;  4BXS A;  4YZU B;  1JV2 B;  1N1I A;  1W7X L;  2W86 A;  3KK6 A;  2JKH L;  4D0E A;  3HS6 A;  4D90 A;  3QMO A;  3NJP C;  1IQH L;  3BPS E;  2Y5G L;  2XC0 L;  1PXX A;  4ZH8 B;  1FF7 A;  2W2N E;  4NGA L;  3HPT A;  2NPR A;  1HRE A;  5JBA E;  2BQ6 A;  1F0R B;  1JBU L;  2XC4 L;  4X8S L;  3C9A C;  1MQ6 L;  3POY A;  1WHF A;  3MDL A;  2XBX L;  1ADX A;  2BOK L;  2BO2 A;  4A7I A;  2CJI B;  1Z6C A;  3KQE L;  1EMO A;  4XLW A;  3Q3K B;  4RRY A;  3N8Y B;  2UWO B;  2Y81 B;  5JVY A;  1HCG B;  2BOU A;  3U73 A;  5JB9 E;  3M36 L;  4LOR A;  3KL6 B;  3HO3 A;  5CKN A;  1G1S A;  1HT5 A;  2W2M E;  5JW1 A;  2WFT A;  2PUQ L;  4RS0 A;  1KLJ L;  1P0S L;  4ZAE B;  2EI6 B;  1ATE A;  4MMZ B;  2MGR A;  2RA0 L;  3PGH A;  3DEM A;  2J94 B;  4X8U L;  4O1Z A;  3FCS B;  2W3K B;  1J9C L;  1M1X B;  3Q7D A;  1IQL L;  1G2M B;  3NT1 A;  3P5B L;  1HZ8 A;  3BT2 A;  4JYU L;  4BTI A;  1LQD A;  3CFW A;  3SOV A;  5L2Z L;  3CA7 A;  2WPJ E;  2UWP B;  1PTH A;  4M11 A;  5JBB E;  1IOE L;  3HS7 A;  3OLT A;  2J34 B;  5K0H B;  3N8Y A;  1IOX A;  4NG9 L;  3LIW B;  1DX5 I;  1EBV A;  2Y5F L;  2VWM K;  3RR3 A;  1IGZ A;  2M74 A;  5JBC E;  3SOQ A;  3ELA L;  2P93 L;  1KLO A;  3CS7 L;  4Z6A L;  4Y7A B;  1KLI L;  1W8B L;  1YO8 A;  1HT8 A;  2YGQ A;  1Z6E L;  4X8V L;  1IVO C;  3U7U G;  2P94 L;  3H5C B;  3LTG D;  1HX2 A;  4AQT A;  3ENS A;  2KL7 A;  2VWL L;  2MHP A;  1NT0 A;  2P3F N;  2WPI E;  3TK6 B;  2J95 B;  1EAI C;  2P95 L;  1A3P A;  1EPG A;  2Y38 A;  2Y7Z B;  1P9J A;  3LN1 A;  1EPJ A;  1HJ7 A;  4JZD L;  2D1J B;  3NTG A;  4ZXY L;  2J38 B;  3TZI A;  3HO5 A;  1ATD A;  3N8V A;  4Y79 B;  3TK5 B;  2P3U A;  1Q4G A;  2GD4 A;  1B9W A;  4OTY A;  3OLU A;  1I0U A;  1IQG L;  1G1Q A;  1DDX A;  1NFY B;  2WG4 B;  2VVC K;  1F7M A;  1G1T A;  2W26 B;  3LC3 B;  5KIR A;  3N8Z A;  3TGF A;  2XBV L;  3ZYJ B;  5IKT A;  1EPH A;  5JB8 E;  2BZ6 L;  1IQF L;  1FAX L;  2WYJ B;  2PHB B;  2W2P E;  5L30 L;  1U8C B;  2WPK E;  4XBM A;  3GCX E;  3LTF B;  2WFX B;  2DDU A;  2P3T A;  1TOZ A;  1UZQ A;  1IQI L;  1F0S B;  5IKV A;  1DVA L;  2FZZ L;  1SZB A;  1URK A;  1CX2 A;  3F1S B;  3LN0 A;  2BOH A;  4D0F A;  5E8D A;  1TPG A;  4JYV L;  4M10 A;  1COU A;  4CUF A;  2WPM E;  2F9B L;  3KQC L;  2FD6 A;  1NFX B;  4RUT A;  4ZHA B;  1HAF A;  2BMG A;  2FLR L;  1WHE A;  2WPH E;  1L3Y A;  2KB9 A;  3KQB L;  1CCF A;  4X8T L;  2EI7 B;  1NFU B;  4JZE L;  4PH9 A;  4BTT A;  5L2Y L;  1YUF A;  2OYE P;  4TGF A;  1IQE L;  4O02 B;  4RRZ A;  4BDW A;  4ISH L;  3V65 B;  5IKR A;  3FBY A;  4Z0K B;  1BF9 A;  2P16 L;  1DIY A;  3TBD A;  3NTB A;  2WZP P;  2I9A A;  1G1R A;  5KN5 C;  4Z0L A;  3CEN L;  2WPL E;  1LMJ A;  2RHP A;  1XDT R;  1K37 A;  2UWL B;  2ADX A;  1IP0 A;  1V3X B;  3FFG L;  1O5D L;  4MMY B;  2J4I B;  4RRW A;  4YT6 L;  4Y71 B;  1CVU A;  3BT1 A;  3ZYI B;  5CKQ A;  1K36 A;  2TGF A;  4CUE A;  3N8X A;  5I46 L;  1QFK L;  5CIS A;  4COX A;  1CQE A;  2K2T A;  1KIG L;  1HAE A;  3TH3 L;  1NQL B;  2P26 A;  5CKM A;  2H9E C;  1EGF A;  1NFW B;  1RFN B;  3K9X A;  4BTU A;  1PGE A;  2FLG A;  1IQN L;  2XBY L;  2VVV L;  1FJS L;  2B7D L;  1NPE B;  1CCV A;  1EZQ B;  3S6X A;  2Y80 B;  1YGC L;  1TLE A;  3HO4 A;  1LPK A;  4OTJ A;  1IQM L;  2WG3 C;  1APO A;  1EPI A;  2MGP A;  1MOX C;  1F7E A;  4BDX A;  1C5M F;  4CSY A;  3EGF A;  2W2O E;  1LPZ A;  2PR3 B;  4BXW A;  1YUK B;  1ATB A;  3M37 L;  2VWO L;  1FE2 A;  1LMM A;  1KSN B;  3KRK A;  4G1M B;  4RRX A;  2YGP A;  5FDQ A;  2P28 B;  1FFM A;  4C16 A;  1FAK L;  1AUT L;  3MQE A;  3SOB B;  2WYG B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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