2B7DL

Factor viia inhibitors: chemical optimization, preclinical pharmacokinetics, pharmacodynamics, and efficacy in a baboon thrombosis model
Total Genus 18
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
18
sequence length
94
structure length
94
Chain Sequence
QCASSPCQNGGSCKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILE
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Blood clotting
source organism Homo sapiens
publication title Factor VIIa inhibitors: Chemical optimization, preclinical pharmacokinetics, pharmacodynamics, and efficacy in an arterial baboon thrombosis model.
pubmed doi rcsb
molecule keywords Coagulation factor VII
total genus 18
structure length 94
sequence length 94
ec nomenclature ec 3.4.21.21: Coagulation factor VIIa.
pdb deposition date 2005-10-04

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
L PF00008 EGF EGF-like domain
L PF00594 Gla Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.25.10 Mainly Beta Ribbon Laminin Laminin 2b7dL02
2.10.25.10 Mainly Beta Ribbon Laminin Laminin 2b7dL01
1NFUB 1P0SL 4CUEA 2WPIE 4D90A 1HT8A 2W86A 3LC5B 5L2YL 1IVOC 1QFKL 2W26B 3POYA 1A3PA 2BMGA 1CQEA 2XC4L 1PRHA 3LN1A 5IKTA 1IOXA 2P3FL 3KK6A 4BDWA 4NGAL 3CFWA 2J34B 2WG3C 2FLGA 4RRZA 4RS0A 2BOHA 4Y6DB 3SOQA 5CKMA 3NTGA 1ZAQA 2XC0L 3HS7A 4D0EA 1IGZA 3ASIA 1YUGA 3SOBB 2EI8B 3N8XA 3HPTA 3U73A 2WPKE 5COXA 2XBXL 1IOEL 1KLOA 6COXA 2VWNL 1IJQA 1TPGA 3Q7DA 4TGFA 4Y76B 1N1IA 3C9AC 3HS6A 2UWLB 3KRKA 2Y38A 3LC3B 1KLJL 1CCFA 1DQBA 1PTHA 2AYLA 1SZBA 2BO2A 1U8CB 1COUA 4Y7BB 2P26A 4ZAEB 4BXSA 3N8WA 4XL1A 1JL9A 1AUTL 3TH3L 4C16A 1CVUA 1IQJL 3ZYIB 3KQEL 2BQ6A 2Y7ZB 1X7AL 1XKBA 1ATAA 3TK6B 2ADXA 3LTGD 1W8BL 3U7UG 1RFNB 1KIGL 4Z0KB 3KL6B 3KQBL 3N8YB 3ELAL 1NFWB 2Y81B 4M11A 5F1AA 4O1ZA 3ZYGA 1J9CL 4ISIL 3SOVA 3CA7A 4Z0LA 1WU1B 3CENL 2BOXA 2FLRL 1EGFA 1MOXC 3BT1A 4ZXXL 2PUQL 1ADXA 1MQ5L 1YO8A 1FAXL 4X8VL 1F0RB 2PHBB 1C5MF 2MGPA 5JVZA 3IITB 2P16L 2FD6A 3M36L 3ZYJB 1JBUL 3GISX 1LPGA 4FM5A 3HO5A 3M37L 3QH0A 1OB1C 1NFXB 2W2QE 2Y5GL 2XBVL 3TK5B 1CCVA 4X8UL 2D1JB 1IQFL 2NPRA 1ATBA 2RNLA 4LMFA 1PXXA 3TBDA 4RUTA 2WG4B 4OTYA 2Y5FL 3GCXE 5JVYA 2WPHE 1EAIC 3TGFA 4CUDA 1EQHA 2J4IB 5IKQA 3V64C 2P28B 5F19A 1M1XB 2KV4A 3MDLA 4G1MB 1B9WA 1EPJA 2K2TA 4CSYA 4PH9A 5IKVA 2VVUL 3F6UL 1I0UA 2MHPA 1JV2B 3K9XA 1G2LB 5FDQA 4LORA 4RRWA 1N7DA 4ZHAB 3V65B 1YUFA 1HRFA 3TZIA 5CISA 1CX2A 3IJEB 1ATDA 4YZUB 3EGFA 4JZDL 5L2ZL 3LIWB 1G2MB 1IQHL 2PR3B 1IQEL 1TLEA 1KLIL 1XFEA 1URKA 5CKQA 1ATEA 2W2ME 3KCGL 5CKNA 2P3UA 2J95B 3N8VA 1LPZA 2I9AA 1K36A 1IQLL 2B7DL 1W7XL 3NT1A 1UZKA 1BF9A 2P94L 1DDXA 1P9JA 2VWLL 4NA9L 1HCGB 1FAKL 4BDXA 2XBWL 1WHEA 1Z6EL 4OTJA 1HJ7A 1IQIL 3KQCL 3FFGL 1G1QA 3ENSA 2VWOL 3RR3A 1DIYA 3NJPC 1PGEA 3OLUA 3BT2A 1U67A 5JB9E 1G1SA 4COXA 2WYGB 2G00L 2YGPA 2Y80B 3BPSE 1UZJA 4YT7L 1EMOA 2EI7B 2J94B 2BQWA 2BQ7A 1EPGA 2KB9A 2M74A 1PFXL 2P93L 2JKHL 3KQDL 1F0SB 1IQGL 1IP0A 3N8ZA 4Y7AB 2J2UB 1DX5I 2BOKL 1Z6CA 1DVAL 4CUFA 1K37A 4Y71B 1NQLB 3H5CB 2WYJB 4MMZB 2XBYL 4O02B 4JYVL 2P95L 3CS7L 2W2NE 2VVCK 1XDTR 5JBCE 3P5BL 2H9EL 1FF7A 2RHPA 3HO3A 5K0HB 1UZQA 1UZPA 5L30L 4E1GA 1FSBA 4RRXA 1NZIA 2W2PE 2YGOA 3HO4A 3R05A 2F9BL 2RA0L 2DDUA 4XLWA 1TOZA 3N8YA 1YGCL 1F7MA 3F1SB 4BTUA 5JBBE 1LQDA 1MQ6L 3LN0A 2FZZL 4ZXYL 2FLBL 1IQNL 2VJ3A 2UWPB 4AQTA 2EI6B 1EQGA 2Y82B 3N8WB 5KIRA 1FE2A 4JZFL 2W3IB 1EBVA 3PGHA 4NG9L 2P3TA 1NPEB 5JBAE 3Q3KB 1HZ8A 1F7EA 4ISHL 2VVVL 5E8DA 1G1RA 2Y7XB 1EPIA 4BTIA 2W3KB 2WPME 5IKRA 5KN5C 2VH6B 1FFMA 4X8TL 4A7IA 4M10A 2VH0B 3HS5A 1NT0A 1L3YA 2VWMK 2W2OE 3FBYA 2OYUP 1KSNB 2Q1JB 4BXWA 2CJIB 1HREA 1WHFA 1APOA 4MMXB 2OYEP 3LTFB 3SW2A 3QCWA 1IQML 1EMNA 1IQKL 2J38B 3NTBA 1HAEA 2WFTA 2BZ6L 2WPJE 2WPLE 5JB8E 2XC5L 1O5DL 4Z6AL 2I9BA 1G1TA 2GD4A 2WFXB 4X8SL 1V3XB 2UWOB 3GCWE 4BTTA 1YUKB 1LMJA 1GK5A 3FCSB 4ZH8B 4RRYA 1HT5A 1XKAL 4JZEL 4Y79B 1APQA 1LPKA 1CVWL 2TGFA 1CEJA 5JW1A 4XBMA 1L5GB 1EZQB 2P3FN 1HX2A 3OLTA 1IGXA 2Y5HL 3QMOA 2KL7A 4D0FA 1NFYB 2MGRA 1Q4GA 3LAQA 1EPHA 1FJSL 4YT6L 3MQEA 2BOUA 2K2SB 5EGMB 4JYUL 4MMYB 1HAFA 5I46L 3DEMA
chains in the Genus database with same CATH superfamily
1NFUB 1P0SL 4CUEA 2WPIE 4D90A 1HT8A 2W86A 3LC5B 5L2YL 1IVOC 1QFKL 2W26B 3POYA 1A3PA 2BMGA 1CQEA 2XC4L 1PRHA 3LN1A 5IKTA 1IOXA 2P3FL 3KK6A 4BDWA 4NGAL 3CFWA 2J34B 2WG3C 2FLGA 4RRZA 4RS0A 2BOHA 4Y6DB 3SOQA 5CKMA 3NTGA 1ZAQA 2XC0L 3HS7A 4D0EA 1IGZA 3ASIA 1YUGA 3SOBB 2EI8B 3N8XA 3HPTA 3U73A 2WPKE 5COXA 2XBXL 1IOEL 1KLOA 6COXA 2VWNL 1IJQA 1TPGA 3Q7DA 4TGFA 4Y76B 1N1IA 3C9AC 3HS6A 2UWLB 3KRKA 2Y38A 3LC3B 1KLJL 1CCFA 1DQBA 2VRSA 1PTHA 2AYLA 1SZBA 2BO2A 1U8CB 1COUA 4Y7BB 2P26A 4ZAEB 4BXSA 3N8WA 4XL1A 1JL9A 1AUTL 3TH3L 4C16A 1CVUA 1IQJL 3ZYIB 3KQEL 2BQ6A 2Y7ZB 1X7AL 1XKBA 1ATAA 3TK6B 2ADXA 3LTGD 1W8BL 3U7UG 1RFNB 1KIGL 4Z0KB 4GU3A 3KL6B 3KQBL 3N8YB 3ELAL 1NFWB 2Y81B 4M11A 5F1AA 4O1ZA 3ZYGA 1J9CL 4ISIL 3SOVA 2JJLA 3CA7A 4Z0LA 1WU1B 3CENL 2BOXA 1QIUA 2FLRL 1EGFA 1MOXC 3BT1A 4ZXXL 2PUQL 1ADXA 1MQ5L 1YO8A 1FAXL 4X8VL 1F0RB 2PHBB 1C5MF 2MGPA 5JVZA 3IITB 2P16L 2FD6A 3M36L 3ZYJB 1JBUL 3GISX 1LPGA 4FM5A 3HO5A 3M37L 3QH0A 1OB1C 1NFXB 2W2QE 2Y5GL 2XBVL 1V1HA 3TK5B 1CCVA 4X8UL 2D1JB 1IQFL 2NPRA 1ATBA 2RNLA 4LMFA 1PXXA 3TBDA 4RUTA 2WG4B 4OTYA 2Y5FL 3GCXE 5JVYA 2WPHE 1EAIC 2BT7A 3TGFA 4CUDA 1EQHA 2J4IB 5IKQA 3V64C 2P28B 5F19A 1M1XB 2KV4A 3MDLA 1LMMA 4G1MB 1B9WA 1EPJA 2K2TA 4CSYA 4PH9A 5IKVA 2VVUL 3F6UL 1I0UA 2MHPA 1JV2B 3K9XA 1G2LB 5FDQA 4LORA 4RRWA 1N7DA 4ZHAB 3V65B 1YUFA 1HRFA 1V1IA 3TZIA 5CISA 1CX2A 3IJEB 1ATDA 2BT8A 4YZUB 3EGFA 4JZDL 5L2ZL 3LIWB 4GU4A 2BSFA 1G2MB 1IQHL 2PR3B 1IQEL 1TLEA 1KLIL 1XFEA 1URKA 5CKQA 1ATEA 2W2ME 3KCGL 5CKNA 2P3UA 2J95B 3N8VA 1LPZA 2I9AA 1K36A 1IQLL 2B7DL 1W7XL 3NT1A 1UZKA 1BF9A 2P94L 1DDXA 1P9JA 2VWLL 4NA9L 2HOXA 1HCGB 1FAKL 4BDXA 2XBWL 1WHEA 1Z6EL 4OTJA 3S6XA 1HJ7A 1IQIL 3KQCL 3FFGL 2YGQA 1G1QA 3ENSA 2VWOL 3RR3A 1DIYA 3NJPC 1PGEA 3OLUA 3BT2A 1U67A 5JB9E 1G1SA 4COXA 2WYGB 2G00L 2YGPA 2Y80B 3BPSE 1UZJA 4YT7L 1EMOA 2EI7B 2J94B 2BQWA 2BQ7A 1EPGA 2KB9A 2M74A 1PFXL 2P93L 2JKHL 3KQDL 1F0SB 1IQGL 1IP0A 3N8ZA 4Y7AB 2J2UB 1DX5I 2BOKL 1Z6CA 1DVAL 4CUFA 1K37A 4Y71B 1NQLB 3H5CB 2WYJB 4MMZB 2XBYL 4O02B 4JYVL 2P95L 3CS7L 2W2NE 2VVCK 1XDTR 5JBCE 3P5BL 2H9EL 1FF7A 2RHPA 3HO3A 5K0HB 1UZQA 1UZPA 5L30L 4E1GA 1FSBA 4RRXA 1NZIA 2W2PE 2YGOA 3HO4A 3R05A 2F9BL 2RA0L 2DDUA 4XLWA 1TOZA 3N8YA 1YGCL 1F7MA 3F1SB 4BTUA 4A94C 5JBBE 1LQDA 1MQ6L 3LN0A 2FZZL 4ZXYL 2FLBL 1IQNL 2VJ3A 2UWPB 4AQTA 2EI6B 1EQGA 2Y82B 3N8WB 5KIRA 1FE2A 4JZFL 2W3IB 1EBVA 3PGHA 4NG9L 2P3TA 1NPEB 2H9EC 5JBAE 3Q3KB 1HZ8A 1F7EA 4ISHL 2VVVL 5E8DA 1G1RA 2Y7XB 1EPIA 4BTIA 2W3KB 2WPME 5IKRA 5KN5C 2VH6B 1FFMA 4X8TL 4A7IA 4M10A 2VH0B 2KNIA 3HS5A 1NT0A 1L3YA 2VWMK 2W2OE 3FBYA 2OYUP 1KSNB 2Q1JB 4BXWA 2CJIB 1HREA 1WHFA 1APOA 4MMXB 2WZPP 2OYEP 3LTFB 3SW2A 3QCWA 1IQML 1EMNA 1IQKL 2J38B 3NTBA 1HAEA 2WFTA 2BZ6L 2WPJE 2WPLE 5JB8E 2XC5L 1KKEA 1O5DL 4Z6AL 2I9BA 1G1TA 2GD4A 2WFXB 4X8SL 1V3XB 2UWOB 3GCWE 4BTTA 1YUKB 1LMJA 1GK5A 3FCSB 4ZH8B 4RRYA 1HT5A 1XKAL 4JZEL 4Y79B 1APQA 1LPKA 1CVWL 2TGFA 1CEJA 5JW1A 4XBMA 1L5GB 1EZQB 2P3FN 1HX2A 3OLTA 1IGXA 2Y5HL 2HORA 3QMOA 1LK9A 2KL7A 4D0FA 1NFYB 2MGRA 1Q4GA 3LAQA 1EPHA 1FJSL 4YT6L 3MQEA 2BOUA 2K2SB 5EGMB 4JYUL 4MMYB 1HAFA 5I46L 3DEMA
chains in the Genus database with same CATH topology
1NFUB 1P0SL 4CUEA 2WPIE 4D90A 1HT8A 2W86A 3LC5B 5L2YL 1IVOC 1QFKL 2W26B 3POYA 1A3PA 2BMGA 1CQEA 2XC4L 1PRHA 3LN1A 5IKTA 1IOXA 2P3FL 3KK6A 4BDWA 4NGAL 3CFWA 2J34B 2WG3C 2FLGA 4RRZA 4RS0A 2BOHA 4Y6DB 3SOQA 5CKMA 3NTGA 1ZAQA 2XC0L 3HS7A 4D0EA 1IGZA 3ASIA 1YUGA 3SOBB 2EI8B 3N8XA 3HPTA 3U73A 2WPKE 5COXA 2XBXL 1IOEL 1KLOA 6COXA 2VWNL 1IJQA 1TPGA 3Q7DA 4TGFA 4Y76B 1N1IA 3C9AC 3HS6A 2UWLB 3KRKA 2Y38A 3LC3B 1KLJL 1CCFA 1DQBA 1PTHA 2AYLA 1SZBA 2BO2A 1U8CB 1COUA 4Y7BB 2P26A 4ZAEB 4BXSA 3N8WA 4XL1A 1JL9A 1AUTL 3TH3L 4C16A 1CVUA 1IQJL 3ZYIB 3KQEL 2BQ6A 2Y7ZB 1X7AL 1XKBA 1ATAA 3TK6B 2ADXA 3LTGD 1W8BL 3U7UG 1RFNB 1KIGL 4Z0KB 3KL6B 3KQBL 3N8YB 3ELAL 1NFWB 2Y81B 4M11A 5F1AA 4O1ZA 3ZYGA 1J9CL 4ISIL 3SOVA 3CA7A 4Z0LA 1WU1B 3CENL 2BOXA 2FLRL 1EGFA 1MOXC 3BT1A 4ZXXL 2PUQL 1ADXA 1MQ5L 1YO8A 1FAXL 4X8VL 1F0RB 2PHBB 1C5MF 2MGPA 5JVZA 3IITB 2P16L 2FD6A 3M36L 3ZYJB 1JBUL 3GISX 1LPGA 4FM5A 3HO5A 3M37L 3QH0A 1OB1C 1NFXB 2W2QE 2Y5GL 2XBVL 3TK5B 1CCVA 4X8UL 2D1JB 1IQFL 2NPRA 1ATBA 2RNLA 4LMFA 1PXXA 3TBDA 4RUTA 2WG4B 4OTYA 2Y5FL 3GCXE 5JVYA 2WPHE 1EAIC 3TGFA 4CUDA 1EQHA 2J4IB 5IKQA 3V64C 2P28B 5F19A 1M1XB 2KV4A 3MDLA 1LMMA 4G1MB 1B9WA 1EPJA 2K2TA 4CSYA 4PH9A 5IKVA 2VVUL 3F6UL 1I0UA 2MHPA 1JV2B 3K9XA 1G2LB 5FDQA 4LORA 4RRWA 1N7DA 4ZHAB 3V65B 1YUFA 1HRFA 3TZIA 5CISA 1CX2A 3IJEB 1ATDA 4YZUB 3EGFA 4JZDL 5L2ZL 3LIWB 1G2MB 1IQHL 2PR3B 1IQEL 1TLEA 1KLIL 1XFEA 1URKA 5CKQA 1ATEA 2W2ME 3KCGL 5CKNA 2P3UA 2J95B 3N8VA 1LPZA 2I9AA 1K36A 1IQLL 2B7DL 1W7XL 3NT1A 1UZKA 1BF9A 2P94L 1DDXA 1P9JA 2VWLL 4NA9L 1HCGB 1FAKL 4BDXA 2XBWL 1WHEA 1Z6EL 4OTJA 3S6XA 1HJ7A 1IQIL 3KQCL 3FFGL 2YGQA 1G1QA 3ENSA 2VWOL 3RR3A 1DIYA 3NJPC 1PGEA 3OLUA 3BT2A 1U67A 5JB9E 1G1SA 4COXA 2WYGB 2G00L 2YGPA 2Y80B 3BPSE 1UZJA 4YT7L 1EMOA 2EI7B 2J94B 2BQWA 2BQ7A 1EPGA 2KB9A 2M74A 1PFXL 2P93L 2JKHL 3KQDL 1F0SB 1IQGL 1IP0A 3N8ZA 4Y7AB 2J2UB 1DX5I 2BOKL 1Z6CA 1DVAL 4CUFA 1K37A 4Y71B 1NQLB 3H5CB 2WYJB 4MMZB 2XBYL 4O02B 4JYVL 2P95L 3CS7L 2W2NE 2VVCK 1XDTR 5JBCE 3P5BL 2H9EL 1FF7A 2RHPA 3HO3A 5K0HB 1UZQA 1UZPA 5L30L 4E1GA 1FSBA 4RRXA 1NZIA 2W2PE 2YGOA 3HO4A 3R05A 2F9BL 2RA0L 2DDUA 4XLWA 1TOZA 3N8YA 1YGCL 1F7MA 3F1SB 4BTUA 4A94C 5JBBE 1LQDA 1MQ6L 3LN0A 2FZZL 4ZXYL 2FLBL 1IQNL 2VJ3A 2UWPB 4AQTA 2EI6B 1EQGA 2Y82B 3N8WB 5KIRA 1FE2A 4JZFL 2W3IB 1EBVA 3PGHA 4NG9L 2P3TA 1NPEB 2H9EC 5JBAE 3Q3KB 1HZ8A 1F7EA 4ISHL 2VVVL 5E8DA 1G1RA 2Y7XB 1EPIA 4BTIA 2W3KB 2WPME 5IKRA 5KN5C 2VH6B 1FFMA 4X8TL 4A7IA 4M10A 2VH0B 2KNIA 3HS5A 1NT0A 1L3YA 2VWMK 2W2OE 3FBYA 2OYUP 1KSNB 2Q1JB 4BXWA 2CJIB 1HREA 1WHFA 1APOA 4MMXB 2WZPP 2OYEP 3LTFB 3SW2A 3QCWA 1IQML 1EMNA 1IQKL 2J38B 3NTBA 1HAEA 2WFTA 2BZ6L 2WPJE 2WPLE 5JB8E 2XC5L 1O5DL 4Z6AL 2I9BA 1G1TA 2GD4A 2WFXB 4X8SL 1V3XB 2UWOB 3GCWE 4BTTA 1YUKB 1LMJA 1GK5A 3FCSB 4ZH8B 4RRYA 1HT5A 1XKAL 4JZEL 4Y79B 1APQA 1LPKA 1CVWL 2TGFA 1CEJA 5JW1A 4XBMA 1L5GB 1EZQB 2P3FN 1HX2A 3OLTA 1IGXA 2Y5HL 3QMOA 2KL7A 4D0FA 1NFYB 2MGRA 1Q4GA 3LAQA 1EPHA 1FJSL 4YT6L 3MQEA 2BOUA 2K2SB 5EGMB 4JYUL 4MMYB 1HAFA 5I46L 3DEMA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1NFU B;  1P0S L;  4CUE A;  2WPI E;  4D90 A;  1HT8 A;  2W86 A;  3LC5 B;  5L2Y L;  1IVO C;  1QFK L;  2W26 B;  3POY A;  1A3P A;  2BMG A;  1CQE A;  2XC4 L;  1PRH A;  3LN1 A;  5IKT A;  1IOX A;  2P3F L;  3KK6 A;  4BDW A;  4NGA L;  3CFW A;  2J34 B;  2WG3 C;  2FLG A;  4RRZ A;  4RS0 A;  2BOH A;  4Y6D B;  3SOQ A;  5CKM A;  3NTG A;  1ZAQ A;  2XC0 L;  3HS7 A;  4D0E A;  1IGZ A;  3ASI A;  1YUG A;  3SOB B;  2EI8 B;  3N8X A;  3HPT A;  3U73 A;  2WPK E;  5COX A;  2XBX L;  1IOE L;  1KLO A;  6COX A;  2VWN L;  1IJQ A;  1TPG A;  3Q7D A;  4TGF A;  4Y76 B;  1N1I A;  3C9A C;  3HS6 A;  2UWL B;  3KRK A;  2Y38 A;  3LC3 B;  1KLJ L;  1CCF A;  1DQB A;  1PTH A;  2AYL A;  1SZB A;  2BO2 A;  1U8C B;  1COU A;  4Y7B B;  2P26 A;  4ZAE B;  4BXS A;  3N8W A;  4XL1 A;  1JL9 A;  1AUT L;  3TH3 L;  4C16 A;  1CVU A;  1IQJ L;  3ZYI B;  3KQE L;  2BQ6 A;  2Y7Z B;  1X7A L;  1XKB A;  1ATA A;  3TK6 B;  2ADX A;  3LTG D;  1W8B L;  3U7U G;  1RFN B;  1KIG L;  4Z0K B;  3KL6 B;  3KQB L;  3N8Y B;  3ELA L;  1NFW B;  2Y81 B;  4M11 A;  5F1A A;  4O1Z A;  3ZYG A;  1J9C L;  4ISI L;  3SOV A;  3CA7 A;  4Z0L A;  1WU1 B;  3CEN L;  2BOX A;  2FLR L;  1EGF A;  1MOX C;  3BT1 A;  4ZXX L;  2PUQ L;  1ADX A;  1MQ5 L;  1YO8 A;  1FAX L;  4X8V L;  1F0R B;  2PHB B;  1C5M F;  2MGP A;  5JVZ A;  3IIT B;  2P16 L;  2FD6 A;  3M36 L;  3ZYJ B;  1JBU L;  3GIS X;  1LPG A;  4FM5 A;  3HO5 A;  3M37 L;  3QH0 A;  1OB1 C;  1NFX B;  2W2Q E;  2Y5G L;  2XBV L;  3TK5 B;  1CCV A;  4X8U L;  2D1J B;  1IQF L;  2NPR A;  1ATB A;  2RNL A;  4LMF A;  1PXX A;  3TBD A;  4RUT A;  2WG4 B;  4OTY A;  2Y5F L;  3GCX E;  5JVY A;  2WPH E;  1EAI C;  3TGF A;  4CUD A;  1EQH A;  2J4I B;  5IKQ A;  3V64 C;  2P28 B;  5F19 A;  1M1X B;  2KV4 A;  3MDL A;  4G1M B;  1B9W A;  1EPJ A;  2K2T A;  4CSY A;  4PH9 A;  5IKV A;  2VVU L;  3F6U L;  1I0U A;  2MHP A;  1JV2 B;  3K9X A;  1G2L B;  5FDQ A;  4LOR A;  4RRW A;  1N7D A;  4ZHA B;  3V65 B;  1YUF A;  1HRF A;  3TZI A;  5CIS A;  1CX2 A;  3IJE B;  1ATD A;  4YZU B;  3EGF A;  4JZD L;  5L2Z L;  3LIW B;  1G2M B;  1IQH L;  2PR3 B;  1IQE L;  1TLE A;  1KLI L;  1XFE A;  1URK A;  5CKQ A;  1ATE A;  2W2M E;  3KCG L;  5CKN A;  2P3U A;  2J95 B;  3N8V A;  1LPZ A;  2I9A A;  1K36 A;  1IQL L;  2B7D L;  1W7X L;  3NT1 A;  1UZK A;  1BF9 A;  2P94 L;  1DDX A;  1P9J A;  2VWL L;  4NA9 L;  1HCG B;  1FAK L;  4BDX A;  2XBW L;  1WHE A;  1Z6E L;  4OTJ A;  1HJ7 A;  1IQI L;  3KQC L;  3FFG L;  1G1Q A;  3ENS A;  2VWO L;  3RR3 A;  1DIY A;  3NJP C;  1PGE A;  3OLU A;  3BT2 A;  1U67 A;  5JB9 E;  1G1S A;  4COX A;  2WYG B;  2G00 L;  2YGP A;  2Y80 B;  3BPS E;  1UZJ A;  4YT7 L;  1EMO A;  2EI7 B;  2J94 B;  2BQW A;  2BQ7 A;  1EPG A;  2KB9 A;  2M74 A;  1PFX L;  2P93 L;  2JKH L;  3KQD L;  1F0S B;  1IQG L;  1IP0 A;  3N8Z A;  4Y7A B;  2J2U B;  1DX5 I;  2BOK L;  1Z6C A;  1DVA L;  4CUF A;  1K37 A;  4Y71 B;  1NQL B;  3H5C B;  2WYJ B;  4MMZ B;  2XBY L;  4O02 B;  4JYV L;  2P95 L;  3CS7 L;  2W2N E;  2VVC K;  1XDT R;  5JBC E;  3P5B L;  2H9E L;  1FF7 A;  2RHP A;  3HO3 A;  5K0H B;  1UZQ A;  1UZP A;  5L30 L;  4E1G A;  1FSB A;  4RRX A;  1NZI A;  2W2P E;  2YGO A;  3HO4 A;  3R05 A;  2F9B L;  2RA0 L;  2DDU A;  4XLW A;  1TOZ A;  3N8Y A;  1YGC L;  1F7M A;  3F1S B;  4BTU A;  5JBB E;  1LQD A;  1MQ6 L;  3LN0 A;  2FZZ L;  4ZXY L;  2FLB L;  1IQN L;  2VJ3 A;  2UWP B;  4AQT A;  2EI6 B;  1EQG A;  2Y82 B;  3N8W B;  5KIR A;  1FE2 A;  4JZF L;  2W3I B;  1EBV A;  3PGH A;  4NG9 L;  2P3T A;  1NPE B;  5JBA E;  3Q3K B;  1HZ8 A;  1F7E A;  4ISH L;  2VVV L;  5E8D A;  1G1R A;  2Y7X B;  1EPI A;  4BTI A;  2W3K B;  2WPM E;  5IKR A;  5KN5 C;  2VH6 B;  1FFM A;  4X8T L;  4A7I A;  4M10 A;  2VH0 B;  3HS5 A;  1NT0 A;  1L3Y A;  2VWM K;  2W2O E;  3FBY A;  2OYU P;  1KSN B;  2Q1J B;  4BXW A;  2CJI B;  1HRE A;  1WHF A;  1APO A;  4MMX B;  2OYE P;  3LTF B;  3SW2 A;  3QCW A;  1IQM L;  1EMN A;  1IQK L;  2J38 B;  3NTB A;  1HAE A;  2WFT A;  2BZ6 L;  2WPJ E;  2WPL E;  5JB8 E;  2XC5 L;  1O5D L;  4Z6A L;  2I9B A;  1G1T A;  2GD4 A;  2WFX B;  4X8S L;  1V3X B;  2UWO B;  3GCW E;  4BTT A;  1YUK B;  1LMJ A;  1GK5 A;  3FCS B;  4ZH8 B;  4RRY A;  1HT5 A;  1XKA L;  4JZE L;  4Y79 B;  1APQ A;  1LPK A;  1CVW L;  2TGF A;  1CEJ A;  5JW1 A;  4XBM A;  1L5G B;  1EZQ B;  2P3F N;  1HX2 A;  3OLT A;  1IGX A;  2Y5H L;  3QMO A;  2KL7 A;  4D0F A;  1NFY B;  2MGR A;  1Q4G A;  3LAQ A;  1EPH A;  1FJS L;  4YT6 L;  3MQE A;  2BOU A;  2K2S B;  5EGM B;  4JYU L;  4MMY B;  1HAF A;  5I46 L;  3DEM A; 
#chains in the Genus database with same CATH topology
 1NFU B;  1P0S L;  4CUE A;  2WPI E;  4D90 A;  1HT8 A;  2W86 A;  3LC5 B;  5L2Y L;  1IVO C;  1QFK L;  2W26 B;  3POY A;  1A3P A;  2BMG A;  1CQE A;  2XC4 L;  1PRH A;  3LN1 A;  5IKT A;  1IOX A;  2P3F L;  3KK6 A;  4BDW A;  4NGA L;  3CFW A;  2J34 B;  2WG3 C;  2FLG A;  4RRZ A;  4RS0 A;  2BOH A;  4Y6D B;  3SOQ A;  5CKM A;  3NTG A;  1ZAQ A;  2XC0 L;  3HS7 A;  4D0E A;  1IGZ A;  3ASI A;  1YUG A;  3SOB B;  2EI8 B;  3N8X A;  3HPT A;  3U73 A;  2WPK E;  5COX A;  2XBX L;  1IOE L;  1KLO A;  6COX A;  2VWN L;  1IJQ A;  1TPG A;  3Q7D A;  4TGF A;  4Y76 B;  1N1I A;  3C9A C;  3HS6 A;  2UWL B;  3KRK A;  2Y38 A;  3LC3 B;  1KLJ L;  1CCF A;  1DQB A;  2VRS A;  1PTH A;  2AYL A;  1SZB A;  2BO2 A;  1U8C B;  1COU A;  4Y7B B;  2P26 A;  4ZAE B;  4BXS A;  3N8W A;  4XL1 A;  1JL9 A;  1AUT L;  3TH3 L;  4C16 A;  1CVU A;  1IQJ L;  3ZYI B;  3KQE L;  2BQ6 A;  2Y7Z B;  1X7A L;  1XKB A;  1ATA A;  3TK6 B;  2ADX A;  3LTG D;  1W8B L;  3U7U G;  1RFN B;  1KIG L;  4Z0K B;  4GU3 A;  3KL6 B;  3KQB L;  3N8Y B;  3ELA L;  1NFW B;  2Y81 B;  4M11 A;  5F1A A;  4O1Z A;  3ZYG A;  1J9C L;  4ISI L;  3SOV A;  2JJL A;  3CA7 A;  4Z0L A;  1WU1 B;  3CEN L;  2BOX A;  1QIU A;  2FLR L;  1EGF A;  1MOX C;  3BT1 A;  4ZXX L;  2PUQ L;  1ADX A;  1MQ5 L;  1YO8 A;  1FAX L;  4X8V L;  1F0R B;  2PHB B;  1C5M F;  2MGP A;  5JVZ A;  3IIT B;  2P16 L;  2FD6 A;  3M36 L;  3ZYJ B;  1JBU L;  3GIS X;  1LPG A;  4FM5 A;  3HO5 A;  3M37 L;  3QH0 A;  1OB1 C;  1NFX B;  2W2Q E;  2Y5G L;  2XBV L;  1V1H A;  3TK5 B;  1CCV A;  4X8U L;  2D1J B;  1IQF L;  2NPR A;  1ATB A;  2RNL A;  4LMF A;  1PXX A;  3TBD A;  4RUT A;  2WG4 B;  4OTY A;  2Y5F L;  3GCX E;  5JVY A;  2WPH E;  1EAI C;  2BT7 A;  3TGF A;  4CUD A;  1EQH A;  2J4I B;  5IKQ A;  3V64 C;  2P28 B;  5F19 A;  1M1X B;  2KV4 A;  3MDL A;  1LMM A;  4G1M B;  1B9W A;  1EPJ A;  2K2T A;  4CSY A;  4PH9 A;  5IKV A;  2VVU L;  3F6U L;  1I0U A;  2MHP A;  1JV2 B;  3K9X A;  1G2L B;  5FDQ A;  4LOR A;  4RRW A;  1N7D A;  4ZHA B;  3V65 B;  1YUF A;  1HRF A;  1V1I A;  3TZI A;  5CIS A;  1CX2 A;  3IJE B;  1ATD A;  2BT8 A;  4YZU B;  3EGF A;  4JZD L;  5L2Z L;  3LIW B;  4GU4 A;  2BSF A;  1G2M B;  1IQH L;  2PR3 B;  1IQE L;  1TLE A;  1KLI L;  1XFE A;  1URK A;  5CKQ A;  1ATE A;  2W2M E;  3KCG L;  5CKN A;  2P3U A;  2J95 B;  3N8V A;  1LPZ A;  2I9A A;  1K36 A;  1IQL L;  2B7D L;  1W7X L;  3NT1 A;  1UZK A;  1BF9 A;  2P94 L;  1DDX A;  1P9J A;  2VWL L;  4NA9 L;  2HOX A;  1HCG B;  1FAK L;  4BDX A;  2XBW L;  1WHE A;  1Z6E L;  4OTJ A;  3S6X A;  1HJ7 A;  1IQI L;  3KQC L;  3FFG L;  2YGQ A;  1G1Q A;  3ENS A;  2VWO L;  3RR3 A;  1DIY A;  3NJP C;  1PGE A;  3OLU A;  3BT2 A;  1U67 A;  5JB9 E;  1G1S A;  4COX A;  2WYG B;  2G00 L;  2YGP A;  2Y80 B;  3BPS E;  1UZJ A;  4YT7 L;  1EMO A;  2EI7 B;  2J94 B;  2BQW A;  2BQ7 A;  1EPG A;  2KB9 A;  2M74 A;  1PFX L;  2P93 L;  2JKH L;  3KQD L;  1F0S B;  1IQG L;  1IP0 A;  3N8Z A;  4Y7A B;  2J2U B;  1DX5 I;  2BOK L;  1Z6C A;  1DVA L;  4CUF A;  1K37 A;  4Y71 B;  1NQL B;  3H5C B;  2WYJ B;  4MMZ B;  2XBY L;  4O02 B;  4JYV L;  2P95 L;  3CS7 L;  2W2N E;  2VVC K;  1XDT R;  5JBC E;  3P5B L;  2H9E L;  1FF7 A;  2RHP A;  3HO3 A;  5K0H B;  1UZQ A;  1UZP A;  5L30 L;  4E1G A;  1FSB A;  4RRX A;  1NZI A;  2W2P E;  2YGO A;  3HO4 A;  3R05 A;  2F9B L;  2RA0 L;  2DDU A;  4XLW A;  1TOZ A;  3N8Y A;  1YGC L;  1F7M A;  3F1S B;  4BTU A;  4A94 C;  5JBB E;  1LQD A;  1MQ6 L;  3LN0 A;  2FZZ L;  4ZXY L;  2FLB L;  1IQN L;  2VJ3 A;  2UWP B;  4AQT A;  2EI6 B;  1EQG A;  2Y82 B;  3N8W B;  5KIR A;  1FE2 A;  4JZF L;  2W3I B;  1EBV A;  3PGH A;  4NG9 L;  2P3T A;  1NPE B;  2H9E C;  5JBA E;  3Q3K B;  1HZ8 A;  1F7E A;  4ISH L;  2VVV L;  5E8D A;  1G1R A;  2Y7X B;  1EPI A;  4BTI A;  2W3K B;  2WPM E;  5IKR A;  5KN5 C;  2VH6 B;  1FFM A;  4X8T L;  4A7I A;  4M10 A;  2VH0 B;  2KNI A;  3HS5 A;  1NT0 A;  1L3Y A;  2VWM K;  2W2O E;  3FBY A;  2OYU P;  1KSN B;  2Q1J B;  4BXW A;  2CJI B;  1HRE A;  1WHF A;  1APO A;  4MMX B;  2WZP P;  2OYE P;  3LTF B;  3SW2 A;  3QCW A;  1IQM L;  1EMN A;  1IQK L;  2J38 B;  3NTB A;  1HAE A;  2WFT A;  2BZ6 L;  2WPJ E;  2WPL E;  5JB8 E;  2XC5 L;  1KKE A;  1O5D L;  4Z6A L;  2I9B A;  1G1T A;  2GD4 A;  2WFX B;  4X8S L;  1V3X B;  2UWO B;  3GCW E;  4BTT A;  1YUK B;  1LMJ A;  1GK5 A;  3FCS B;  4ZH8 B;  4RRY A;  1HT5 A;  1XKA L;  4JZE L;  4Y79 B;  1APQ A;  1LPK A;  1CVW L;  2TGF A;  1CEJ A;  5JW1 A;  4XBM A;  1L5G B;  1EZQ B;  2P3F N;  1HX2 A;  3OLT A;  1IGX A;  2Y5H L;  2HOR A;  3QMO A;  1LK9 A;  2KL7 A;  4D0F A;  1NFY B;  2MGR A;  1Q4G A;  3LAQ A;  1EPH A;  1FJS L;  4YT6 L;  3MQE A;  2BOU A;  2K2S B;  5EGM B;  4JYU L;  4MMY B;  1HAF A;  5I46 L;  3DEM A; 
#chains in the Genus database with same CATH homology
 1NFU B;  1P0S L;  4CUE A;  2WPI E;  4D90 A;  1HT8 A;  2W86 A;  3LC5 B;  5L2Y L;  1IVO C;  1QFK L;  2W26 B;  3POY A;  1A3P A;  2BMG A;  1CQE A;  2XC4 L;  1PRH A;  3LN1 A;  5IKT A;  1IOX A;  2P3F L;  3KK6 A;  4BDW A;  4NGA L;  3CFW A;  2J34 B;  2WG3 C;  2FLG A;  4RRZ A;  4RS0 A;  2BOH A;  4Y6D B;  3SOQ A;  5CKM A;  3NTG A;  1ZAQ A;  2XC0 L;  3HS7 A;  4D0E A;  1IGZ A;  3ASI A;  1YUG A;  3SOB B;  2EI8 B;  3N8X A;  3HPT A;  3U73 A;  2WPK E;  5COX A;  2XBX L;  1IOE L;  1KLO A;  6COX A;  2VWN L;  1IJQ A;  1TPG A;  3Q7D A;  4TGF A;  4Y76 B;  1N1I A;  3C9A C;  3HS6 A;  2UWL B;  3KRK A;  2Y38 A;  3LC3 B;  1KLJ L;  1CCF A;  1DQB A;  1PTH A;  2AYL A;  1SZB A;  2BO2 A;  1U8C B;  1COU A;  4Y7B B;  2P26 A;  4ZAE B;  4BXS A;  3N8W A;  4XL1 A;  1JL9 A;  1AUT L;  3TH3 L;  4C16 A;  1CVU A;  1IQJ L;  3ZYI B;  3KQE L;  2BQ6 A;  2Y7Z B;  1X7A L;  1XKB A;  1ATA A;  3TK6 B;  2ADX A;  3LTG D;  1W8B L;  3U7U G;  1RFN B;  1KIG L;  4Z0K B;  3KL6 B;  3KQB L;  3N8Y B;  3ELA L;  1NFW B;  2Y81 B;  4M11 A;  5F1A A;  4O1Z A;  3ZYG A;  1J9C L;  4ISI L;  3SOV A;  3CA7 A;  4Z0L A;  1WU1 B;  3CEN L;  2BOX A;  2FLR L;  1EGF A;  1MOX C;  3BT1 A;  4ZXX L;  2PUQ L;  1ADX A;  1MQ5 L;  1YO8 A;  1FAX L;  4X8V L;  1F0R B;  2PHB B;  1C5M F;  2MGP A;  5JVZ A;  3IIT B;  2P16 L;  2FD6 A;  3M36 L;  3ZYJ B;  1JBU L;  3GIS X;  1LPG A;  4FM5 A;  3HO5 A;  3M37 L;  3QH0 A;  1OB1 C;  1NFX B;  2W2Q E;  2Y5G L;  2XBV L;  3TK5 B;  1CCV A;  4X8U L;  2D1J B;  1IQF L;  2NPR A;  1ATB A;  2RNL A;  4LMF A;  1PXX A;  3TBD A;  4RUT A;  2WG4 B;  4OTY A;  2Y5F L;  3GCX E;  5JVY A;  2WPH E;  1EAI C;  3TGF A;  4CUD A;  1EQH A;  2J4I B;  5IKQ A;  3V64 C;  2P28 B;  5F19 A;  1M1X B;  2KV4 A;  3MDL A;  1LMM A;  4G1M B;  1B9W A;  1EPJ A;  2K2T A;  4CSY A;  4PH9 A;  5IKV A;  2VVU L;  3F6U L;  1I0U A;  2MHP A;  1JV2 B;  3K9X A;  1G2L B;  5FDQ A;  4LOR A;  4RRW A;  1N7D A;  4ZHA B;  3V65 B;  1YUF A;  1HRF A;  3TZI A;  5CIS A;  1CX2 A;  3IJE B;  1ATD A;  4YZU B;  3EGF A;  4JZD L;  5L2Z L;  3LIW B;  1G2M B;  1IQH L;  2PR3 B;  1IQE L;  1TLE A;  1KLI L;  1XFE A;  1URK A;  5CKQ A;  1ATE A;  2W2M E;  3KCG L;  5CKN A;  2P3U A;  2J95 B;  3N8V A;  1LPZ A;  2I9A A;  1K36 A;  1IQL L;  2B7D L;  1W7X L;  3NT1 A;  1UZK A;  1BF9 A;  2P94 L;  1DDX A;  1P9J A;  2VWL L;  4NA9 L;  1HCG B;  1FAK L;  4BDX A;  2XBW L;  1WHE A;  1Z6E L;  4OTJ A;  3S6X A;  1HJ7 A;  1IQI L;  3KQC L;  3FFG L;  2YGQ A;  1G1Q A;  3ENS A;  2VWO L;  3RR3 A;  1DIY A;  3NJP C;  1PGE A;  3OLU A;  3BT2 A;  1U67 A;  5JB9 E;  1G1S A;  4COX A;  2WYG B;  2G00 L;  2YGP A;  2Y80 B;  3BPS E;  1UZJ A;  4YT7 L;  1EMO A;  2EI7 B;  2J94 B;  2BQW A;  2BQ7 A;  1EPG A;  2KB9 A;  2M74 A;  1PFX L;  2P93 L;  2JKH L;  3KQD L;  1F0S B;  1IQG L;  1IP0 A;  3N8Z A;  4Y7A B;  2J2U B;  1DX5 I;  2BOK L;  1Z6C A;  1DVA L;  4CUF A;  1K37 A;  4Y71 B;  1NQL B;  3H5C B;  2WYJ B;  4MMZ B;  2XBY L;  4O02 B;  4JYV L;  2P95 L;  3CS7 L;  2W2N E;  2VVC K;  1XDT R;  5JBC E;  3P5B L;  2H9E L;  1FF7 A;  2RHP A;  3HO3 A;  5K0H B;  1UZQ A;  1UZP A;  5L30 L;  4E1G A;  1FSB A;  4RRX A;  1NZI A;  2W2P E;  2YGO A;  3HO4 A;  3R05 A;  2F9B L;  2RA0 L;  2DDU A;  4XLW A;  1TOZ A;  3N8Y A;  1YGC L;  1F7M A;  3F1S B;  4BTU A;  4A94 C;  5JBB E;  1LQD A;  1MQ6 L;  3LN0 A;  2FZZ L;  4ZXY L;  2FLB L;  1IQN L;  2VJ3 A;  2UWP B;  4AQT A;  2EI6 B;  1EQG A;  2Y82 B;  3N8W B;  5KIR A;  1FE2 A;  4JZF L;  2W3I B;  1EBV A;  3PGH A;  4NG9 L;  2P3T A;  1NPE B;  2H9E C;  5JBA E;  3Q3K B;  1HZ8 A;  1F7E A;  4ISH L;  2VVV L;  5E8D A;  1G1R A;  2Y7X B;  1EPI A;  4BTI A;  2W3K B;  2WPM E;  5IKR A;  5KN5 C;  2VH6 B;  1FFM A;  4X8T L;  4A7I A;  4M10 A;  2VH0 B;  2KNI A;  3HS5 A;  1NT0 A;  1L3Y A;  2VWM K;  2W2O E;  3FBY A;  2OYU P;  1KSN B;  2Q1J B;  4BXW A;  2CJI B;  1HRE A;  1WHF A;  1APO A;  4MMX B;  2WZP P;  2OYE P;  3LTF B;  3SW2 A;  3QCW A;  1IQM L;  1EMN A;  1IQK L;  2J38 B;  3NTB A;  1HAE A;  2WFT A;  2BZ6 L;  2WPJ E;  2WPL E;  5JB8 E;  2XC5 L;  1O5D L;  4Z6A L;  2I9B A;  1G1T A;  2GD4 A;  2WFX B;  4X8S L;  1V3X B;  2UWO B;  3GCW E;  4BTT A;  1YUK B;  1LMJ A;  1GK5 A;  3FCS B;  4ZH8 B;  4RRY A;  1HT5 A;  1XKA L;  4JZE L;  4Y79 B;  1APQ A;  1LPK A;  1CVW L;  2TGF A;  1CEJ A;  5JW1 A;  4XBM A;  1L5G B;  1EZQ B;  2P3F N;  1HX2 A;  3OLT A;  1IGX A;  2Y5H L;  3QMO A;  2KL7 A;  4D0F A;  1NFY B;  2MGR A;  1Q4G A;  3LAQ A;  1EPH A;  1FJS L;  4YT6 L;  3MQE A;  2BOU A;  2K2S B;  5EGM B;  4JYU L;  4MMY B;  1HAF A;  5I46 L;  3DEM A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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