2P3TA

Crystal structure of human factor xa complexed with 3-chloro-4-(2-methylamino-imidazol-1-ylmethyl)-thiophene-2-carboxylic acid [4-chloro-2-(5-chloro-pyridin-2-ylcarbamoyl)-6-methoxy-phenyl]-amide
Total Genus 12
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
12
sequence length
52
structure length
52
Chain Sequence
KLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLE
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Thiophene-anthranilamides as highly potent and orally available factor xa inhibitors.
pubmed doi rcsb
molecule tags Blood clotting
molecule keywords Coagulation factor X
total genus 12
structure length 52
sequence length 52
ec nomenclature ec 3.4.21.6: Coagulation factor Xa.
pdb deposition date 2007-03-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF14670 FXa_inhibition Coagulation Factor Xa inhibitory site
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.25.10 Mainly Beta Ribbon Laminin Laminin 2p3tA00
3MQEA 3KK6A 4OTYA 1APQA 4JYUL 2Y5HL 3KCGL 3KQCL 1DVAL 2ADXA 3FBYA 4ISHL 1URKA 2UWLB 2W2QE 1HCGB 1W7XL 3NTGA 4CUDA 3MDLA 2PR3B 3U73A 1EQGA 3SOQA 1F0RB 1DX5I 1KIGL 4CUEA 1LMJA 2YGPA 1MQ5L 3POYA 1ZAQA 1WHEA 4E1GA 1U67A 1HJ7A 3SOBB 1COUA 1Q4GA 4NGAL 3GISX 2BO2A 2M74A 1JV2B 1IQIL 2CJIB 5L30L 2KV4A 5JB9E 2K2SB 1FFMA 2P95L 2BOHA 4ZXXL 1N1IA 1O5DL 2WPJE 2P16L 2P3FL 5IKTA 1FAXL 1NFUB 1G1RA 2P26A 1EAIC 3TK5B 2TGFA 4JZDL 3HO3A 2WPHE 2F9BL 4BDXA 2W86A 3IITB 4LORA 5F1AA 3ZYIB 5JBCE 3RR3A 1UZQA 2Y80B 4D0FA 1UZPA 2KB9A 2VVVL 4RS0A 1JBUL 2XBYL 1EZQB 1LPGA 4O1ZA 3QH0A 1IQEL 4BTIA 1I0UA 1F7MA 1KLIL 2WFTA 3OLUA 2UWPB 2XBWL 4M10A 3PGHA 3HS5A 1Z6CA 2Y38A 1IQFL 4XBMA 3TZIA 1L3YA 1IVOC 5E8DA 2OYEP 4C16A 2W26B 1NFWB 3Q3KB 5JBAE 4RRWA 2P28B 1WU1B 1G2MB 1CEJA 3V65B 4D90A 2Q1JB 5EGMB 2PUQL 5F19A 4CSYA 2JKHL 1TOZA 2BOUA 2VH0B 3M37L 1FSBA 1MOXC 3HO4A 4BXWA 2VWLL 2XBXL 3LN0A 1PRHA 2OYUP 3ZYJB 2Y5GL 3HS7A 4Z0KB 1CVWL 2Y7ZB 4BDWA 4RRYA 2DDUA 4PH9A 3F1SB 5IKQA 1CQEA 1HT5A 4JYVL 5I46L 2FZZL 4TGFA 5CKQA 5JVYA 1L5GB 2MGRA 3N8WA 2W3IB 2W2PE 3DEMA 3LN1A 4X8TL 2Y5FL 2WPME 3TGFA 1V3XB 1CVUA 1IQHL 5IKVA 2BOXA 1EPIA 5JVZA 3ELAL 1CCVA 3GCXE 3LAQA 5K0HB 5KIRA 1EMOA 1F7EA 1XFEA 1MQ6L 3KRKA 2WG4B 1YUGA 2BOKL 3N8ZA 2NPRA 4NA9L 4YT7L 1HZ8A 4Z0LA 1XKAL 1HRFA 1NPEB 2WPIE 2XC5L 1ADXA 5JB8E 1BF9A 2VVCK 1IGZA 1UZJA 1XKBA 1IQGL 2XC4L 2P3FN 3IJEB 2VWOL 3CFWA 2D1JB 1APOA 3QCWA 1A3PA 3BT2A 4CUFA 4NG9L 2MGPA 4ZXYL 3K9XA 2EI7B 1X7AL 3F6UL 2VVUL 1DQBA 1C5MF 1OB1C 1K37A 1JL9A 1LPZA 1G2LB 3ASIA 1FAKL 1U8CB 4YT6L 3HS6A 2BZ6L 1HREA 3KQBL 2VWMK 3NJPC 1NZIA 3EGFA 1ATEA 3N8WB 1B9WA 4X8UL 1EMNA 3CA7A 4A7IA 4FM5A 1YUFA 3ZYGA 1PFXL 1HT8A 4Y7AB 2BMGA 4RRXA 1NFXB 2EI8B 4COXA 4X8SL 3KQDL 4MMZB 1EPGA 1EPJA 1IQNL 1ATDA 2H9EL 2VH6B 3LTFB 1IOEL 4ZHAB 1PTHA 4ZAEB 1KLJL 4LMFA 1RFNB 4Z6AL 3GCWE 3N8XA 3N8VA 4Y6DB 1NT0A 2P3UA 4ZH8B 2GD4A 4M11A 2VWNL 4XLWA 2J38B 3HO5A 4OTJA 5KN5C 1Z6EL 1CX2A 4BTTA 2BQ6A 2W2ME 1ATBA 1TPGA 2KL7A 2WPKE 2Y81B 2Y7XB 3FFGL 3TH3L 1XDTR 2XC0L 4Y7BB 3N8YA 3LC5B 3R05A 2WG3C 5IKRA 1IJQA 1QFKL 1AUTL 5JBBE 5COXA 3Q7DA 1G1SA 2RNLA 2J34B 3KQEL 2FD6A 2W2NE 1KSNB 3LTGD 2VJ3A 3HPTA 5CKMA 1FF7A 1NQLB 5FDQA 3FCSB 3P5BL 4ISIL 1EQHA 3KL6B 2RHPA 1LPKA 2BQ7A 4AQTA 1EGFA 2WPLE 2WYJB 4BTUA 1TLEA 4JZEL 2FLRL 3CS7L 3BPSE 3M36L 2FLGA 1PXXA 3TBDA 3C9AC 1K36A 2I9BA 4RRZA 1YGCL 2J95B 4MMYB 4XL1A 3U7UG 2Y82B 3SW2A 1DDXA 3TK6B 2UWOB 3V64C 1EPHA 2B7DL 2FLBL 4Y76B 2P93L 1ATAA 1M1XB 1NFYB 4RUTA 2J4IB 4O02B 2EI6B 2XBVL 2P94L 1YO8A 4BXSA 1P9JA 2P3TA 1HAEA 1N7DA 2J94B 4Y79B 1PGEA 1FJSL 1FE2A 1LQDA 1IQLL 4Y71B 4MMXB 3LC3B 1YUKB 2J2UB 1WHFA 4YZUB 1UZKA 2G00L 2AYLA 1F0SB 1SZBA 4X8VL 1W8BL 3NTBA 5L2ZL 1CCFA 4JZFL 3QMOA 2BQWA 3ENSA 3CENL 3SOVA 2W2OE 1GK5A 1IGXA 2RA0L 4G1MB 1IP0A 1KLOA 2WYGB 3N8YB 3H5CB 1DIYA 1G1TA 6COXA 1HAFA 2K2TA 1IQKL 1IOXA 1J9CL 1G1QA 2PHBB 3LIWB 1P0SL 5JW1A 1IQML 2YGOA 2W3KB 2I9AA 4D0EA 5L2YL 2WFXB 3NT1A 5CKNA 5CISA 3OLTA 1IQJL 2MHPA 1EBVA 1HX2A 3BT1A
chains in the Genus database with same CATH superfamily
3MQEA 3KK6A 4OTYA 1APQA 4JYUL 2Y5HL 3KCGL 3KQCL 1DVAL 2ADXA 3FBYA 4ISHL 1URKA 2UWLB 2W2QE 1HCGB 1W7XL 3NTGA 4CUDA 3MDLA 2PR3B 3U73A 1EQGA 3SOQA 1F0RB 1DX5I 1KIGL 4CUEA 1LMJA 2YGPA 4GU3A 1MQ5L 3POYA 3S6XA 2YGQA 1ZAQA 1WHEA 4E1GA 1U67A 1HJ7A 1LK9A 3SOBB 1COUA 1Q4GA 4NGAL 3GISX 2BO2A 2M74A 1JV2B 1IQIL 2CJIB 5L30L 2KV4A 1LMMA 5JB9E 2K2SB 1FFMA 2P95L 2BOHA 4ZXXL 1N1IA 1O5DL 2WPJE 2P16L 2P3FL 5IKTA 1FAXL 1NFUB 1G1RA 2P26A 1EAIC 3TK5B 2TGFA 4JZDL 3HO3A 2WPHE 2F9BL 4BDXA 2W86A 3IITB 4LORA 5F1AA 3ZYIB 5JBCE 3RR3A 1UZQA 2Y80B 4D0FA 1UZPA 2KB9A 2VVVL 4RS0A 1JBUL 2XBYL 1EZQB 1LPGA 4O1ZA 3QH0A 1IQEL 4BTIA 1I0UA 1F7MA 1KLIL 2WFTA 3OLUA 2UWPB 2XBWL 4M10A 3PGHA 3HS5A 1Z6CA 2Y38A 1IQFL 4XBMA 3TZIA 1L3YA 1IVOC 5E8DA 2OYEP 4C16A 2W26B 1NFWB 3Q3KB 5JBAE 4RRWA 2P28B 1WU1B 1G2MB 1CEJA 3V65B 4D90A 2Q1JB 5EGMB 2PUQL 5F19A 4CSYA 2JKHL 1TOZA 2BOUA 2VH0B 3M37L 1FSBA 1MOXC 3HO4A 4BXWA 2VWLL 2XBXL 3LN0A 1PRHA 2OYUP 3ZYJB 2Y5GL 3HS7A 4Z0KB 1CVWL 2Y7ZB 4BDWA 4RRYA 2DDUA 4PH9A 3F1SB 1V1IA 5IKQA 1CQEA 1HT5A 4JYVL 5I46L 2FZZL 4TGFA 5CKQA 5JVYA 1L5GB 2MGRA 3N8WA 2W3IB 2W2PE 2H9EC 3DEMA 3LN1A 4X8TL 2Y5FL 2WPME 3TGFA 1V3XB 1CVUA 1IQHL 5IKVA 2BOXA 1EPIA 5JVZA 3ELAL 2BSFA 3GCXE 3LAQA 1CCVA 5K0HB 5KIRA 1EMOA 1F7EA 1XFEA 1KKEA 1MQ6L 3KRKA 2WG4B 1YUGA 2BOKL 3N8ZA 2NPRA 2BT8A 4NA9L 4YT7L 1HZ8A 4Z0LA 1XKAL 1HRFA 1NPEB 2WPIE 2XC5L 1ADXA 5JB8E 1BF9A 2VVCK 1IGZA 1UZJA 1XKBA 1IQGL 2XC4L 2P3FN 3IJEB 2VWOL 3CFWA 2D1JB 1APOA 3QCWA 1A3PA 3BT2A 4CUFA 4NG9L 2MGPA 4ZXYL 3K9XA 2EI7B 1X7AL 3F6UL 2VVUL 1DQBA 1C5MF 1OB1C 1K37A 1JL9A 1LPZA 2BT7A 1G2LB 3ASIA 2WZPP 1FAKL 1U8CB 4YT6L 3HS6A 2HOXA 2BZ6L 1HREA 3KQBL 2VWMK 3NJPC 1NZIA 3EGFA 1ATEA 3N8WB 1B9WA 4X8UL 1EMNA 3CA7A 4A7IA 4FM5A 1YUFA 3ZYGA 1PFXL 1HT8A 4Y7AB 2BMGA 4RRXA 1NFXB 2EI8B 4COXA 4X8SL 3KQDL 4MMZB 1EPGA 1EPJA 1IQNL 1ATDA 2H9EL 2VH6B 3LTFB 1IOEL 4ZHAB 1PTHA 4ZAEB 1KLJL 4LMFA 1RFNB 4Z6AL 3GCWE 3N8XA 3N8VA 4Y6DB 1NT0A 2P3UA 4ZH8B 2GD4A 2HORA 4M11A 2VWNL 4XLWA 2J38B 3HO5A 4OTJA 5KN5C 1Z6EL 1CX2A 4BTTA 2BQ6A 2W2ME 1ATBA 1TPGA 2KL7A 2WPKE 2Y81B 2Y7XB 3FFGL 3TH3L 1XDTR 2XC0L 4Y7BB 3N8YA 3LC5B 3R05A 2WG3C 5IKRA 1IJQA 1QFKL 1AUTL 5JBBE 1V1HA 5COXA 3Q7DA 1G1SA 2RNLA 2J34B 3KQEL 2FD6A 2W2NE 1KSNB 3LTGD 2KNIA 2VJ3A 3HPTA 5CKMA 1FF7A 1NQLB 5FDQA 3FCSB 3P5BL 4ISIL 1EQHA 3KL6B 2RHPA 1LPKA 2BQ7A 4AQTA 1EGFA 2WPLE 2WYJB 4BTUA 1TLEA 4JZEL 2FLRL 3CS7L 3BPSE 3M36L 2FLGA 1PXXA 3TBDA 3C9AC 1K36A 2I9BA 4RRZA 1YGCL 2J95B 4GU4A 4MMYB 4XL1A 3U7UG 2Y82B 3SW2A 1DDXA 3TK6B 2UWOB 3V64C 1EPHA 2B7DL 2FLBL 4Y76B 2P93L 1ATAA 1M1XB 1NFYB 4RUTA 2J4IB 4O02B 2EI6B 4A94C 2XBVL 2P94L 1YO8A 4BXSA 1P9JA 2P3TA 1HAEA 1N7DA 2J94B 4Y79B 1PGEA 1FJSL 1QIUA 1FE2A 1LQDA 1IQLL 4Y71B 4MMXB 3LC3B 1YUKB 2J2UB 1WHFA 4YZUB 1UZKA 2G00L 2AYLA 1F0SB 1SZBA 2JJLA 4X8VL 1W8BL 3NTBA 5L2ZL 1CCFA 4JZFL 3QMOA 2BQWA 3ENSA 3CENL 3SOVA 2W2OE 1GK5A 1IGXA 2RA0L 4G1MB 1IP0A 1KLOA 2WYGB 3N8YB 3H5CB 1DIYA 2VRSA 1G1TA 6COXA 1HAFA 2K2TA 1IQKL 1IOXA 1J9CL 1G1QA 2PHBB 3LIWB 1P0SL 5JW1A 1IQML 2YGOA 2W3KB 2I9AA 4D0EA 5L2YL 2WFXB 3NT1A 5CKNA 5CISA 3OLTA 1IQJL 2MHPA 1EBVA 1HX2A 3BT1A
chains in the Genus database with same CATH topology
3MQEA 3KK6A 4OTYA 1APQA 4JYUL 2Y5HL 3KCGL 3KQCL 1DVAL 2ADXA 3FBYA 4ISHL 1URKA 2UWLB 2W2QE 1HCGB 1W7XL 3NTGA 4CUDA 3MDLA 2PR3B 3U73A 1EQGA 3SOQA 1F0RB 1DX5I 1KIGL 4CUEA 1LMJA 2YGPA 1MQ5L 3POYA 3S6XA 2YGQA 1ZAQA 1WHEA 4E1GA 1U67A 1HJ7A 3SOBB 1COUA 1Q4GA 4NGAL 3GISX 2BO2A 2M74A 1JV2B 1IQIL 2CJIB 5L30L 2KV4A 1LMMA 5JB9E 2K2SB 1FFMA 2P95L 2BOHA 4ZXXL 1N1IA 1O5DL 2WPJE 2P16L 2P3FL 5IKTA 1FAXL 1NFUB 1G1RA 2P26A 1EAIC 3TK5B 2TGFA 4JZDL 3HO3A 2WPHE 2F9BL 4BDXA 2W86A 3IITB 4LORA 5F1AA 3ZYIB 5JBCE 3RR3A 1UZQA 2Y80B 4D0FA 1UZPA 2KB9A 2VVVL 4RS0A 1JBUL 2XBYL 1EZQB 1LPGA 4O1ZA 3QH0A 1IQEL 4BTIA 1I0UA 1F7MA 1KLIL 2WFTA 3OLUA 2UWPB 2XBWL 4M10A 3PGHA 3HS5A 1Z6CA 2Y38A 1IQFL 4XBMA 3TZIA 1L3YA 1IVOC 5E8DA 2OYEP 4C16A 2W26B 1NFWB 3Q3KB 5JBAE 4RRWA 2P28B 1WU1B 1G2MB 1CEJA 3V65B 4D90A 2Q1JB 5EGMB 2PUQL 5F19A 4CSYA 2JKHL 1TOZA 2BOUA 2VH0B 3M37L 1FSBA 1MOXC 3HO4A 4BXWA 2VWLL 2XBXL 3LN0A 1PRHA 2OYUP 3ZYJB 2Y5GL 3HS7A 4Z0KB 1CVWL 2Y7ZB 4BDWA 4RRYA 2DDUA 4PH9A 3F1SB 5IKQA 1CQEA 1HT5A 4JYVL 5I46L 2FZZL 4TGFA 5CKQA 5JVYA 1L5GB 2MGRA 3N8WA 2W3IB 2W2PE 2H9EC 3DEMA 3LN1A 4X8TL 2Y5FL 2WPME 3TGFA 1V3XB 1CVUA 1IQHL 5IKVA 2BOXA 1EPIA 5JVZA 3ELAL 1CCVA 3GCXE 3LAQA 5K0HB 5KIRA 1EMOA 1F7EA 1XFEA 1MQ6L 3KRKA 2WG4B 1YUGA 2BOKL 3N8ZA 2NPRA 4NA9L 4YT7L 1HZ8A 4Z0LA 1XKAL 1HRFA 1NPEB 2WPIE 2XC5L 1ADXA 5JB8E 1BF9A 2VVCK 1IGZA 1UZJA 1XKBA 1IQGL 2XC4L 2P3FN 3IJEB 2VWOL 3CFWA 2D1JB 1APOA 3QCWA 1A3PA 3BT2A 4CUFA 4NG9L 2MGPA 4ZXYL 3K9XA 2EI7B 1X7AL 3F6UL 2VVUL 1DQBA 1C5MF 1OB1C 1K37A 1JL9A 1LPZA 1G2LB 3ASIA 2WZPP 1FAKL 1U8CB 4YT6L 3HS6A 2BZ6L 1HREA 3KQBL 2VWMK 3NJPC 1NZIA 3EGFA 1ATEA 3N8WB 1B9WA 4X8UL 1EMNA 3CA7A 4A7IA 4FM5A 1YUFA 3ZYGA 1PFXL 1HT8A 4Y7AB 2BMGA 4RRXA 1NFXB 2EI8B 4COXA 4X8SL 3KQDL 4MMZB 1EPGA 1EPJA 1IQNL 1ATDA 2H9EL 2VH6B 3LTFB 1IOEL 4ZHAB 1PTHA 4ZAEB 1KLJL 4LMFA 1RFNB 4Z6AL 3GCWE 3N8XA 3N8VA 4Y6DB 1NT0A 2P3UA 4ZH8B 2GD4A 4M11A 2VWNL 4XLWA 2J38B 3HO5A 4OTJA 5KN5C 1Z6EL 1CX2A 4BTTA 2BQ6A 2W2ME 1ATBA 1TPGA 2KL7A 2WPKE 2Y81B 2Y7XB 3FFGL 3TH3L 1XDTR 2XC0L 4Y7BB 3N8YA 3LC5B 3R05A 2WG3C 5IKRA 1IJQA 1QFKL 1AUTL 5JBBE 5COXA 3Q7DA 1G1SA 2RNLA 2J34B 3KQEL 2FD6A 2W2NE 1KSNB 3LTGD 2KNIA 2VJ3A 3HPTA 5CKMA 1FF7A 1NQLB 5FDQA 3FCSB 3P5BL 4ISIL 1EQHA 3KL6B 2RHPA 1LPKA 2BQ7A 4AQTA 1EGFA 2WPLE 2WYJB 4BTUA 1TLEA 4JZEL 2FLRL 3CS7L 3BPSE 3M36L 2FLGA 1PXXA 3TBDA 3C9AC 1K36A 2I9BA 4RRZA 1YGCL 2J95B 4MMYB 4XL1A 3U7UG 2Y82B 3SW2A 1DDXA 3TK6B 2UWOB 3V64C 1EPHA 2B7DL 2FLBL 4Y76B 2P93L 1ATAA 1M1XB 1NFYB 4RUTA 2J4IB 4O02B 2EI6B 4A94C 2XBVL 2P94L 1YO8A 4BXSA 1P9JA 2P3TA 1HAEA 1N7DA 2J94B 4Y79B 1PGEA 1FJSL 1FE2A 1LQDA 1IQLL 4Y71B 4MMXB 3LC3B 1YUKB 2J2UB 1WHFA 4YZUB 1UZKA 2G00L 2AYLA 1F0SB 1SZBA 4X8VL 1W8BL 3NTBA 5L2ZL 1CCFA 4JZFL 3QMOA 2BQWA 3ENSA 3CENL 3SOVA 2W2OE 1GK5A 1IGXA 2RA0L 4G1MB 1IP0A 1KLOA 2WYGB 3N8YB 3H5CB 1DIYA 1G1TA 6COXA 1HAFA 2K2TA 1IQKL 1IOXA 1J9CL 1G1QA 2PHBB 3LIWB 1P0SL 5JW1A 1IQML 2YGOA 2W3KB 2I9AA 4D0EA 5L2YL 2WFXB 3NT1A 5CKNA 5CISA 3OLTA 1IQJL 2MHPA 1EBVA 1HX2A 3BT1A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3MQE A;  3KK6 A;  4OTY A;  1APQ A;  4JYU L;  2Y5H L;  3KCG L;  3KQC L;  1DVA L;  2ADX A;  3FBY A;  4ISH L;  1URK A;  2UWL B;  2W2Q E;  1HCG B;  1W7X L;  3NTG A;  4CUD A;  3MDL A;  2PR3 B;  3U73 A;  1EQG A;  3SOQ A;  1F0R B;  1DX5 I;  1KIG L;  4CUE A;  1LMJ A;  2YGP A;  1MQ5 L;  3POY A;  1ZAQ A;  1WHE A;  4E1G A;  1U67 A;  1HJ7 A;  3SOB B;  1COU A;  1Q4G A;  4NGA L;  3GIS X;  2BO2 A;  2M74 A;  1JV2 B;  1IQI L;  2CJI B;  5L30 L;  2KV4 A;  5JB9 E;  2K2S B;  1FFM A;  2P95 L;  2BOH A;  4ZXX L;  1N1I A;  1O5D L;  2WPJ E;  2P16 L;  2P3F L;  5IKT A;  1FAX L;  1NFU B;  1G1R A;  2P26 A;  1EAI C;  3TK5 B;  2TGF A;  4JZD L;  3HO3 A;  2WPH E;  2F9B L;  4BDX A;  2W86 A;  3IIT B;  4LOR A;  5F1A A;  3ZYI B;  5JBC E;  3RR3 A;  1UZQ A;  2Y80 B;  4D0F A;  1UZP A;  2KB9 A;  2VVV L;  4RS0 A;  1JBU L;  2XBY L;  1EZQ B;  1LPG A;  4O1Z A;  3QH0 A;  1IQE L;  4BTI A;  1I0U A;  1F7M A;  1KLI L;  2WFT A;  3OLU A;  2UWP B;  2XBW L;  4M10 A;  3PGH A;  3HS5 A;  1Z6C A;  2Y38 A;  1IQF L;  4XBM A;  3TZI A;  1L3Y A;  1IVO C;  5E8D A;  2OYE P;  4C16 A;  2W26 B;  1NFW B;  3Q3K B;  5JBA E;  4RRW A;  2P28 B;  1WU1 B;  1G2M B;  1CEJ A;  3V65 B;  4D90 A;  2Q1J B;  5EGM B;  2PUQ L;  5F19 A;  4CSY A;  2JKH L;  1TOZ A;  2BOU A;  2VH0 B;  3M37 L;  1FSB A;  1MOX C;  3HO4 A;  4BXW A;  2VWL L;  2XBX L;  3LN0 A;  1PRH A;  2OYU P;  3ZYJ B;  2Y5G L;  3HS7 A;  4Z0K B;  1CVW L;  2Y7Z B;  4BDW A;  4RRY A;  2DDU A;  4PH9 A;  3F1S B;  5IKQ A;  1CQE A;  1HT5 A;  4JYV L;  5I46 L;  2FZZ L;  4TGF A;  5CKQ A;  5JVY A;  1L5G B;  2MGR A;  3N8W A;  2W3I B;  2W2P E;  3DEM A;  3LN1 A;  4X8T L;  2Y5F L;  2WPM E;  3TGF A;  1V3X B;  1CVU A;  1IQH L;  5IKV A;  2BOX A;  1EPI A;  5JVZ A;  3ELA L;  1CCV A;  3GCX E;  3LAQ A;  5K0H B;  5KIR A;  1EMO A;  1F7E A;  1XFE A;  1MQ6 L;  3KRK A;  2WG4 B;  1YUG A;  2BOK L;  3N8Z A;  2NPR A;  4NA9 L;  4YT7 L;  1HZ8 A;  4Z0L A;  1XKA L;  1HRF A;  1NPE B;  2WPI E;  2XC5 L;  1ADX A;  5JB8 E;  1BF9 A;  2VVC K;  1IGZ A;  1UZJ A;  1XKB A;  1IQG L;  2XC4 L;  2P3F N;  3IJE B;  2VWO L;  3CFW A;  2D1J B;  1APO A;  3QCW A;  1A3P A;  3BT2 A;  4CUF A;  4NG9 L;  2MGP A;  4ZXY L;  3K9X A;  2EI7 B;  1X7A L;  3F6U L;  2VVU L;  1DQB A;  1C5M F;  1OB1 C;  1K37 A;  1JL9 A;  1LPZ A;  1G2L B;  3ASI A;  1FAK L;  1U8C B;  4YT6 L;  3HS6 A;  2BZ6 L;  1HRE A;  3KQB L;  2VWM K;  3NJP C;  1NZI A;  3EGF A;  1ATE A;  3N8W B;  1B9W A;  4X8U L;  1EMN A;  3CA7 A;  4A7I A;  4FM5 A;  1YUF A;  3ZYG A;  1PFX L;  1HT8 A;  4Y7A B;  2BMG A;  4RRX A;  1NFX B;  2EI8 B;  4COX A;  4X8S L;  3KQD L;  4MMZ B;  1EPG A;  1EPJ A;  1IQN L;  1ATD A;  2H9E L;  2VH6 B;  3LTF B;  1IOE L;  4ZHA B;  1PTH A;  4ZAE B;  1KLJ L;  4LMF A;  1RFN B;  4Z6A L;  3GCW E;  3N8X A;  3N8V A;  4Y6D B;  1NT0 A;  2P3U A;  4ZH8 B;  2GD4 A;  4M11 A;  2VWN L;  4XLW A;  2J38 B;  3HO5 A;  4OTJ A;  5KN5 C;  1Z6E L;  1CX2 A;  4BTT A;  2BQ6 A;  2W2M E;  1ATB A;  1TPG A;  2KL7 A;  2WPK E;  2Y81 B;  2Y7X B;  3FFG L;  3TH3 L;  1XDT R;  2XC0 L;  4Y7B B;  3N8Y A;  3LC5 B;  3R05 A;  2WG3 C;  5IKR A;  1IJQ A;  1QFK L;  1AUT L;  5JBB E;  5COX A;  3Q7D A;  1G1S A;  2RNL A;  2J34 B;  3KQE L;  2FD6 A;  2W2N E;  1KSN B;  3LTG D;  2VJ3 A;  3HPT A;  5CKM A;  1FF7 A;  1NQL B;  5FDQ A;  3FCS B;  3P5B L;  4ISI L;  1EQH A;  3KL6 B;  2RHP A;  1LPK A;  2BQ7 A;  4AQT A;  1EGF A;  2WPL E;  2WYJ B;  4BTU A;  1TLE A;  4JZE L;  2FLR L;  3CS7 L;  3BPS E;  3M36 L;  2FLG A;  1PXX A;  3TBD A;  3C9A C;  1K36 A;  2I9B A;  4RRZ A;  1YGC L;  2J95 B;  4MMY B;  4XL1 A;  3U7U G;  2Y82 B;  3SW2 A;  1DDX A;  3TK6 B;  2UWO B;  3V64 C;  1EPH A;  2B7D L;  2FLB L;  4Y76 B;  2P93 L;  1ATA A;  1M1X B;  1NFY B;  4RUT A;  2J4I B;  4O02 B;  2EI6 B;  2XBV L;  2P94 L;  1YO8 A;  4BXS A;  1P9J A;  2P3T A;  1HAE A;  1N7D A;  2J94 B;  4Y79 B;  1PGE A;  1FJS L;  1FE2 A;  1LQD A;  1IQL L;  4Y71 B;  4MMX B;  3LC3 B;  1YUK B;  2J2U B;  1WHF A;  4YZU B;  1UZK A;  2G00 L;  2AYL A;  1F0S B;  1SZB A;  4X8V L;  1W8B L;  3NTB A;  5L2Z L;  1CCF A;  4JZF L;  3QMO A;  2BQW A;  3ENS A;  3CEN L;  3SOV A;  2W2O E;  1GK5 A;  1IGX A;  2RA0 L;  4G1M B;  1IP0 A;  1KLO A;  2WYG B;  3N8Y B;  3H5C B;  1DIY A;  1G1T A;  6COX A;  1HAF A;  2K2T A;  1IQK L;  1IOX A;  1J9C L;  1G1Q A;  2PHB B;  3LIW B;  1P0S L;  5JW1 A;  1IQM L;  2YGO A;  2W3K B;  2I9A A;  4D0E A;  5L2Y L;  2WFX B;  3NT1 A;  5CKN A;  5CIS A;  3OLT A;  1IQJ L;  2MHP A;  1EBV A;  1HX2 A;  3BT1 A; 
#chains in the Genus database with same CATH topology
 3MQE A;  3KK6 A;  4OTY A;  1APQ A;  4JYU L;  2Y5H L;  3KCG L;  3KQC L;  1DVA L;  2ADX A;  3FBY A;  4ISH L;  1URK A;  2UWL B;  2W2Q E;  1HCG B;  1W7X L;  3NTG A;  4CUD A;  3MDL A;  2PR3 B;  3U73 A;  1EQG A;  3SOQ A;  1F0R B;  1DX5 I;  1KIG L;  4CUE A;  1LMJ A;  2YGP A;  4GU3 A;  1MQ5 L;  3POY A;  3S6X A;  2YGQ A;  1ZAQ A;  1WHE A;  4E1G A;  1U67 A;  1HJ7 A;  1LK9 A;  3SOB B;  1COU A;  1Q4G A;  4NGA L;  3GIS X;  2BO2 A;  2M74 A;  1JV2 B;  1IQI L;  2CJI B;  5L30 L;  2KV4 A;  1LMM A;  5JB9 E;  2K2S B;  1FFM A;  2P95 L;  2BOH A;  4ZXX L;  1N1I A;  1O5D L;  2WPJ E;  2P16 L;  2P3F L;  5IKT A;  1FAX L;  1NFU B;  1G1R A;  2P26 A;  1EAI C;  3TK5 B;  2TGF A;  4JZD L;  3HO3 A;  2WPH E;  2F9B L;  4BDX A;  2W86 A;  3IIT B;  4LOR A;  5F1A A;  3ZYI B;  5JBC E;  3RR3 A;  1UZQ A;  2Y80 B;  4D0F A;  1UZP A;  2KB9 A;  2VVV L;  4RS0 A;  1JBU L;  2XBY L;  1EZQ B;  1LPG A;  4O1Z A;  3QH0 A;  1IQE L;  4BTI A;  1I0U A;  1F7M A;  1KLI L;  2WFT A;  3OLU A;  2UWP B;  2XBW L;  4M10 A;  3PGH A;  3HS5 A;  1Z6C A;  2Y38 A;  1IQF L;  4XBM A;  3TZI A;  1L3Y A;  1IVO C;  5E8D A;  2OYE P;  4C16 A;  2W26 B;  1NFW B;  3Q3K B;  5JBA E;  4RRW A;  2P28 B;  1WU1 B;  1G2M B;  1CEJ A;  3V65 B;  4D90 A;  2Q1J B;  5EGM B;  2PUQ L;  5F19 A;  4CSY A;  2JKH L;  1TOZ A;  2BOU A;  2VH0 B;  3M37 L;  1FSB A;  1MOX C;  3HO4 A;  4BXW A;  2VWL L;  2XBX L;  3LN0 A;  1PRH A;  2OYU P;  3ZYJ B;  2Y5G L;  3HS7 A;  4Z0K B;  1CVW L;  2Y7Z B;  4BDW A;  4RRY A;  2DDU A;  4PH9 A;  3F1S B;  1V1I A;  5IKQ A;  1CQE A;  1HT5 A;  4JYV L;  5I46 L;  2FZZ L;  4TGF A;  5CKQ A;  5JVY A;  1L5G B;  2MGR A;  3N8W A;  2W3I B;  2W2P E;  2H9E C;  3DEM A;  3LN1 A;  4X8T L;  2Y5F L;  2WPM E;  3TGF A;  1V3X B;  1CVU A;  1IQH L;  5IKV A;  2BOX A;  1EPI A;  5JVZ A;  3ELA L;  2BSF A;  3GCX E;  3LAQ A;  1CCV A;  5K0H B;  5KIR A;  1EMO A;  1F7E A;  1XFE A;  1KKE A;  1MQ6 L;  3KRK A;  2WG4 B;  1YUG A;  2BOK L;  3N8Z A;  2NPR A;  2BT8 A;  4NA9 L;  4YT7 L;  1HZ8 A;  4Z0L A;  1XKA L;  1HRF A;  1NPE B;  2WPI E;  2XC5 L;  1ADX A;  5JB8 E;  1BF9 A;  2VVC K;  1IGZ A;  1UZJ A;  1XKB A;  1IQG L;  2XC4 L;  2P3F N;  3IJE B;  2VWO L;  3CFW A;  2D1J B;  1APO A;  3QCW A;  1A3P A;  3BT2 A;  4CUF A;  4NG9 L;  2MGP A;  4ZXY L;  3K9X A;  2EI7 B;  1X7A L;  3F6U L;  2VVU L;  1DQB A;  1C5M F;  1OB1 C;  1K37 A;  1JL9 A;  1LPZ A;  2BT7 A;  1G2L B;  3ASI A;  2WZP P;  1FAK L;  1U8C B;  4YT6 L;  3HS6 A;  2HOX A;  2BZ6 L;  1HRE A;  3KQB L;  2VWM K;  3NJP C;  1NZI A;  3EGF A;  1ATE A;  3N8W B;  1B9W A;  4X8U L;  1EMN A;  3CA7 A;  4A7I A;  4FM5 A;  1YUF A;  3ZYG A;  1PFX L;  1HT8 A;  4Y7A B;  2BMG A;  4RRX A;  1NFX B;  2EI8 B;  4COX A;  4X8S L;  3KQD L;  4MMZ B;  1EPG A;  1EPJ A;  1IQN L;  1ATD A;  2H9E L;  2VH6 B;  3LTF B;  1IOE L;  4ZHA B;  1PTH A;  4ZAE B;  1KLJ L;  4LMF A;  1RFN B;  4Z6A L;  3GCW E;  3N8X A;  3N8V A;  4Y6D B;  1NT0 A;  2P3U A;  4ZH8 B;  2GD4 A;  2HOR A;  4M11 A;  2VWN L;  4XLW A;  2J38 B;  3HO5 A;  4OTJ A;  5KN5 C;  1Z6E L;  1CX2 A;  4BTT A;  2BQ6 A;  2W2M E;  1ATB A;  1TPG A;  2KL7 A;  2WPK E;  2Y81 B;  2Y7X B;  3FFG L;  3TH3 L;  1XDT R;  2XC0 L;  4Y7B B;  3N8Y A;  3LC5 B;  3R05 A;  2WG3 C;  5IKR A;  1IJQ A;  1QFK L;  1AUT L;  5JBB E;  1V1H A;  5COX A;  3Q7D A;  1G1S A;  2RNL A;  2J34 B;  3KQE L;  2FD6 A;  2W2N E;  1KSN B;  3LTG D;  2KNI A;  2VJ3 A;  3HPT A;  5CKM A;  1FF7 A;  1NQL B;  5FDQ A;  3FCS B;  3P5B L;  4ISI L;  1EQH A;  3KL6 B;  2RHP A;  1LPK A;  2BQ7 A;  4AQT A;  1EGF A;  2WPL E;  2WYJ B;  4BTU A;  1TLE A;  4JZE L;  2FLR L;  3CS7 L;  3BPS E;  3M36 L;  2FLG A;  1PXX A;  3TBD A;  3C9A C;  1K36 A;  2I9B A;  4RRZ A;  1YGC L;  2J95 B;  4GU4 A;  4MMY B;  4XL1 A;  3U7U G;  2Y82 B;  3SW2 A;  1DDX A;  3TK6 B;  2UWO B;  3V64 C;  1EPH A;  2B7D L;  2FLB L;  4Y76 B;  2P93 L;  1ATA A;  1M1X B;  1NFY B;  4RUT A;  2J4I B;  4O02 B;  2EI6 B;  4A94 C;  2XBV L;  2P94 L;  1YO8 A;  4BXS A;  1P9J A;  2P3T A;  1HAE A;  1N7D A;  2J94 B;  4Y79 B;  1PGE A;  1FJS L;  1QIU A;  1FE2 A;  1LQD A;  1IQL L;  4Y71 B;  4MMX B;  3LC3 B;  1YUK B;  2J2U B;  1WHF A;  4YZU B;  1UZK A;  2G00 L;  2AYL A;  1F0S B;  1SZB A;  2JJL A;  4X8V L;  1W8B L;  3NTB A;  5L2Z L;  1CCF A;  4JZF L;  3QMO A;  2BQW A;  3ENS A;  3CEN L;  3SOV A;  2W2O E;  1GK5 A;  1IGX A;  2RA0 L;  4G1M B;  1IP0 A;  1KLO A;  2WYG B;  3N8Y B;  3H5C B;  1DIY A;  2VRS A;  1G1T A;  6COX A;  1HAF A;  2K2T A;  1IQK L;  1IOX A;  1J9C L;  1G1Q A;  2PHB B;  3LIW B;  1P0S L;  5JW1 A;  1IQM L;  2YGO A;  2W3K B;  2I9A A;  4D0E A;  5L2Y L;  2WFX B;  3NT1 A;  5CKN A;  5CIS A;  3OLT A;  1IQJ L;  2MHP A;  1EBV A;  1HX2 A;  3BT1 A; 
#chains in the Genus database with same CATH homology
 3MQE A;  3KK6 A;  4OTY A;  1APQ A;  4JYU L;  2Y5H L;  3KCG L;  3KQC L;  1DVA L;  2ADX A;  3FBY A;  4ISH L;  1URK A;  2UWL B;  2W2Q E;  1HCG B;  1W7X L;  3NTG A;  4CUD A;  3MDL A;  2PR3 B;  3U73 A;  1EQG A;  3SOQ A;  1F0R B;  1DX5 I;  1KIG L;  4CUE A;  1LMJ A;  2YGP A;  1MQ5 L;  3POY A;  3S6X A;  2YGQ A;  1ZAQ A;  1WHE A;  4E1G A;  1U67 A;  1HJ7 A;  3SOB B;  1COU A;  1Q4G A;  4NGA L;  3GIS X;  2BO2 A;  2M74 A;  1JV2 B;  1IQI L;  2CJI B;  5L30 L;  2KV4 A;  1LMM A;  5JB9 E;  2K2S B;  1FFM A;  2P95 L;  2BOH A;  4ZXX L;  1N1I A;  1O5D L;  2WPJ E;  2P16 L;  2P3F L;  5IKT A;  1FAX L;  1NFU B;  1G1R A;  2P26 A;  1EAI C;  3TK5 B;  2TGF A;  4JZD L;  3HO3 A;  2WPH E;  2F9B L;  4BDX A;  2W86 A;  3IIT B;  4LOR A;  5F1A A;  3ZYI B;  5JBC E;  3RR3 A;  1UZQ A;  2Y80 B;  4D0F A;  1UZP A;  2KB9 A;  2VVV L;  4RS0 A;  1JBU L;  2XBY L;  1EZQ B;  1LPG A;  4O1Z A;  3QH0 A;  1IQE L;  4BTI A;  1I0U A;  1F7M A;  1KLI L;  2WFT A;  3OLU A;  2UWP B;  2XBW L;  4M10 A;  3PGH A;  3HS5 A;  1Z6C A;  2Y38 A;  1IQF L;  4XBM A;  3TZI A;  1L3Y A;  1IVO C;  5E8D A;  2OYE P;  4C16 A;  2W26 B;  1NFW B;  3Q3K B;  5JBA E;  4RRW A;  2P28 B;  1WU1 B;  1G2M B;  1CEJ A;  3V65 B;  4D90 A;  2Q1J B;  5EGM B;  2PUQ L;  5F19 A;  4CSY A;  2JKH L;  1TOZ A;  2BOU A;  2VH0 B;  3M37 L;  1FSB A;  1MOX C;  3HO4 A;  4BXW A;  2VWL L;  2XBX L;  3LN0 A;  1PRH A;  2OYU P;  3ZYJ B;  2Y5G L;  3HS7 A;  4Z0K B;  1CVW L;  2Y7Z B;  4BDW A;  4RRY A;  2DDU A;  4PH9 A;  3F1S B;  5IKQ A;  1CQE A;  1HT5 A;  4JYV L;  5I46 L;  2FZZ L;  4TGF A;  5CKQ A;  5JVY A;  1L5G B;  2MGR A;  3N8W A;  2W3I B;  2W2P E;  2H9E C;  3DEM A;  3LN1 A;  4X8T L;  2Y5F L;  2WPM E;  3TGF A;  1V3X B;  1CVU A;  1IQH L;  5IKV A;  2BOX A;  1EPI A;  5JVZ A;  3ELA L;  1CCV A;  3GCX E;  3LAQ A;  5K0H B;  5KIR A;  1EMO A;  1F7E A;  1XFE A;  1MQ6 L;  3KRK A;  2WG4 B;  1YUG A;  2BOK L;  3N8Z A;  2NPR A;  4NA9 L;  4YT7 L;  1HZ8 A;  4Z0L A;  1XKA L;  1HRF A;  1NPE B;  2WPI E;  2XC5 L;  1ADX A;  5JB8 E;  1BF9 A;  2VVC K;  1IGZ A;  1UZJ A;  1XKB A;  1IQG L;  2XC4 L;  2P3F N;  3IJE B;  2VWO L;  3CFW A;  2D1J B;  1APO A;  3QCW A;  1A3P A;  3BT2 A;  4CUF A;  4NG9 L;  2MGP A;  4ZXY L;  3K9X A;  2EI7 B;  1X7A L;  3F6U L;  2VVU L;  1DQB A;  1C5M F;  1OB1 C;  1K37 A;  1JL9 A;  1LPZ A;  1G2L B;  3ASI A;  2WZP P;  1FAK L;  1U8C B;  4YT6 L;  3HS6 A;  2BZ6 L;  1HRE A;  3KQB L;  2VWM K;  3NJP C;  1NZI A;  3EGF A;  1ATE A;  3N8W B;  1B9W A;  4X8U L;  1EMN A;  3CA7 A;  4A7I A;  4FM5 A;  1YUF A;  3ZYG A;  1PFX L;  1HT8 A;  4Y7A B;  2BMG A;  4RRX A;  1NFX B;  2EI8 B;  4COX A;  4X8S L;  3KQD L;  4MMZ B;  1EPG A;  1EPJ A;  1IQN L;  1ATD A;  2H9E L;  2VH6 B;  3LTF B;  1IOE L;  4ZHA B;  1PTH A;  4ZAE B;  1KLJ L;  4LMF A;  1RFN B;  4Z6A L;  3GCW E;  3N8X A;  3N8V A;  4Y6D B;  1NT0 A;  2P3U A;  4ZH8 B;  2GD4 A;  4M11 A;  2VWN L;  4XLW A;  2J38 B;  3HO5 A;  4OTJ A;  5KN5 C;  1Z6E L;  1CX2 A;  4BTT A;  2BQ6 A;  2W2M E;  1ATB A;  1TPG A;  2KL7 A;  2WPK E;  2Y81 B;  2Y7X B;  3FFG L;  3TH3 L;  1XDT R;  2XC0 L;  4Y7B B;  3N8Y A;  3LC5 B;  3R05 A;  2WG3 C;  5IKR A;  1IJQ A;  1QFK L;  1AUT L;  5JBB E;  5COX A;  3Q7D A;  1G1S A;  2RNL A;  2J34 B;  3KQE L;  2FD6 A;  2W2N E;  1KSN B;  3LTG D;  2KNI A;  2VJ3 A;  3HPT A;  5CKM A;  1FF7 A;  1NQL B;  5FDQ A;  3FCS B;  3P5B L;  4ISI L;  1EQH A;  3KL6 B;  2RHP A;  1LPK A;  2BQ7 A;  4AQT A;  1EGF A;  2WPL E;  2WYJ B;  4BTU A;  1TLE A;  4JZE L;  2FLR L;  3CS7 L;  3BPS E;  3M36 L;  2FLG A;  1PXX A;  3TBD A;  3C9A C;  1K36 A;  2I9B A;  4RRZ A;  1YGC L;  2J95 B;  4MMY B;  4XL1 A;  3U7U G;  2Y82 B;  3SW2 A;  1DDX A;  3TK6 B;  2UWO B;  3V64 C;  1EPH A;  2B7D L;  2FLB L;  4Y76 B;  2P93 L;  1ATA A;  1M1X B;  1NFY B;  4RUT A;  2J4I B;  4O02 B;  2EI6 B;  4A94 C;  2XBV L;  2P94 L;  1YO8 A;  4BXS A;  1P9J A;  2P3T A;  1HAE A;  1N7D A;  2J94 B;  4Y79 B;  1PGE A;  1FJS L;  1FE2 A;  1LQD A;  1IQL L;  4Y71 B;  4MMX B;  3LC3 B;  1YUK B;  2J2U B;  1WHF A;  4YZU B;  1UZK A;  2G00 L;  2AYL A;  1F0S B;  1SZB A;  4X8V L;  1W8B L;  3NTB A;  5L2Z L;  1CCF A;  4JZF L;  3QMO A;  2BQW A;  3ENS A;  3CEN L;  3SOV A;  2W2O E;  1GK5 A;  1IGX A;  2RA0 L;  4G1M B;  1IP0 A;  1KLO A;  2WYG B;  3N8Y B;  3H5C B;  1DIY A;  1G1T A;  6COX A;  1HAF A;  2K2T A;  1IQK L;  1IOX A;  1J9C L;  1G1Q A;  2PHB B;  3LIW B;  1P0S L;  5JW1 A;  1IQM L;  2YGO A;  2W3K B;  2I9A A;  4D0E A;  5L2Y L;  2WFX B;  3NT1 A;  5CKN A;  5CIS A;  3OLT A;  1IQJ L;  2MHP A;  1EBV A;  1HX2 A;  3BT1 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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