2VH6B

Structure and property based design of factor xa inhibitors: pyrrolidin-2-ones with biaryl p4 motifs
Total Genus 12
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
12
sequence length
54
structure length
54
Chain Sequence
TRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLE
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase
publication title Structure and Property Based Design of Factor Xa Inhibitors: Pyrrolidin-2-Ones with Biaryl P4 Motifs.
pubmed doi rcsb
molecule keywords ACTIVATED FACTOR XA HEAVY CHAIN
total genus 12
structure length 54
sequence length 54
ec nomenclature ec 3.4.21.6: Coagulation factor Xa.
pdb deposition date 2007-11-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF00008 EGF EGF-like domain
B PF14670 FXa_inhibition Coagulation Factor Xa inhibitory site
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.25.10 Mainly Beta Ribbon Laminin Laminin 2vh6B00
5KIRA 3P5BL 3Q7DA 3LN1A 1APQA 2W2NE 2EI6B 4M10A 1NPEB 1EQHA 1HAFA 2FLGA 4XL1A 2B7DL 1ATEA 5IKRA 2P3TA 1PRHA 1CQEA 1NT0A 1IQJL 4X8UL 2VVVL 3KRKA 1DX5I 1IQHL 5CISA 3TBDA 5JBCE 1F0SB 2VVUL 1JV2B 2Y5GL 2XBVL 3IITB 1IQNL 1TLEA 3FFGL 1DDXA 4ISHL 2VVCK 3H5CB 2P3FL 3U73A 3NTBA 4D0FA 3GCWE 4TGFA 2XC4L 3Q3KB 4ZXXL 3SOVA 3QMOA 4BDXA 4MMYB 2CJIB 4ZXYL 1MQ6L 3HPTA 4AQTA 2Y80B 3EGFA 1WU1B 4YT6L 1ATBA 2JKHL 2Y7ZB 2FLRL 2EI7B 1EZQB 1I0UA 2P93L 2W2ME 1DQBA 1YGCL 2P94L 4X8TL 2J4IB 1DIYA 3HS6A 1IQEL 1X7AL 4BTTA 3HO3A 4Y71B 3N8WA 5CKQA 4BTIA 1ATDA 2KL7A 1YUGA 1YUKB 4YZUB 1NZIA 2WG3C 1K37A 1QFKL 1LPZA 1PGEA 4RRXA 1M1XB 1HCGB 5IKVA 2WPKE 1FAXL 3N8ZA 2Y82B 1KLJL 3CFWA 4RRZA 3NT1A 2Y81B 5L30L 1G2MB 2BQWA 1FFMA 1IGXA 4CSYA 1NFUB 4JZEL 1WHFA 2G00L 2I9BA 1EBVA 3M36L 1IOEL 2P3UA 4JYUL 3GISX 1G2LB 1FJSL 2K2SB 1EPGA 1MOXC 3F1SB 3SW2A 2NPRA 3HS5A 3HO5A 2XBWL 4BXWA 2EI8B 1LMJA 1XFEA 4C16A 1F7EA 3BT1A 1FE2A 1GK5A 2BOXA 5IKTA 4RRWA 4X8VL 1EMOA 2XBYL 3LIWB 3SOBB 1W8BL 2Y7XB 4BTUA 1G1RA 1YO8A 6COXA 1PXXA 1YUFA 2WPME 1P9JA 1APOA 3LAQA 1EQGA 1COUA 2P3FN 2WFTA 2I9AA 4JZDL 2FD6A 3N8YB 2WYGB 4RRYA 1N1IA 1FSBA 2W3IB 2VJ3A 4Y7AB 2W2QE 1ATAA 2P95L 2VH0B 3ENSA 4RUTA 2WPJE 2Y38A 4O02B 3MQEA 1IQFL 1RFNB 2OYUP 2FLBL 2VWMK 2F9BL 4CUFA 2UWOB 2XC0L 2M74A 1DVAL 2J94B 3ELAL 4BDWA 1P0SL 2OYEP 1JBUL 2FZZL 5FDQA 1O5DL 2P16L 3CA7A 1W7XL 1EPIA 2W2OE 4E1GA 1Z6EL 3POYA 1XKBA 1IOXA 1UZPA 3LTGD 3TK6B 2WPIE 1IVOC 1UZJA 4OTYA 2J38B 1L3YA 3OLTA 1Q4GA 1NQLB 2J34B 3N8XA 4ISIL 5IKQA 4CUDA 1KSNB 1F0RB 1HT8A 3V65B 4NG9L 3N8YA 1PFXL 4XBMA 4XLWA 2RA0L 2UWLB 2AYLA 2MGRA 3ZYJB 1CEJA 1OB1C 4JZFL 1U67A 1NFYB 1L5GB 3KK6A 3R05A 3M37L 4CUEA 1CVUA 1N7DA 3NJPC 4X8SL 1B9WA 4NGAL 1SZBA 5CKMA 5I46L 3MDLA 4LMFA 2XC5L 4RS0A 1IQKL 1MQ5L 1KLIL 3KQBL 2Q1JB 2Y5FL 5F19A 5JVYA 3OLUA 3CS7L 5E8DA 1NFWB 4OTJA 2W3KB 4NA9L 4LORA 4ZHAB 2RNLA 1KIGL 2UWPB 2WFXB 1PTHA 3SOQA 4D90A 4D0EA 1G1QA 3KCGL 3RR3A 2PR3B 2GD4A 1ADXA 1EPHA 2BQ7A 1EGFA 2ADXA 1URKA 3TZIA 3TK5B 5JW1A 1XDTR 2W26B 3HO4A 1IP0A 2WG4B 5JVZA 4ZH8B 3LC3B 2K2TA 4O1ZA 2H9EL 4M11A 1G1TA 3QCWA 3HS7A 3KQCL 3TGFA 5KN5C 2P28B 1J9CL 5EGMB 3LC5B 5L2YL 1LPKA 1EPJA 1HX2A 2W86A 3V64C 4YT7L 4MMZB 4ZAEB 3DEMA 2Y5HL 4BXSA 3ASIA 1HT5A 4Y79B 1HRFA 2J2UB 3IJEB 5JB9E 2TGFA 5JB8E 1TOZA 3PGHA 1FF7A 5COXA 3K9XA 3C9AC 1C5MF 2VH6B 2BOUA 4Y6DB 1NFXB 1IQIL 2MGPA 5JBAE 4COXA 2W2PE 1K36A 1HZ8A 2KB9A 3GCXE 2BQ6A 4MMXB 5K0HB 4A7IA 1CVWL 4Z0LA 1Z6CA 2P26A 3F6UL 1HJ7A 1IQGL 2VWOL 3KQDL 3TH3L 1EAIC 2BOKL 3FCSB 3N8VA 2PUQL 1TPGA 5F1AA 2BZ6L 2J95B 3FBYA 1XKAL 2DDUA 2KV4A 1A3PA 3ZYGA 1CCFA 1AUTL 2PHBB 1U8CB 1UZKA 1F7MA 1LQDA 5CKNA 3U7UG 5JBBE 3ZYIB 1IQLL 4G1MB 3LN0A 3BPSE 4Y7BB 3KL6B 2YGOA 3CENL 2BMGA 1FAKL 1LPGA 2BOHA 4Y76B 2VWLL 1CCVA 2VWNL 4Z0KB 2BO2A 2WPHE 3NTGA 3LTFB 2XBXL 1BF9A 1EMNA 2YGPA 5L2ZL 3QH0A 2MHPA 1HAEA 1IJQA 1CX2A 2D1JB 1HREA 1JL9A 1IQML 1UZQA 1WHEA 2WYJB 1G1SA 2WPLE 4Z6AL 3N8WB 4FM5A 1V3XB 3KQEL 3BT2A 4JYVL 1KLOA 4PH9A 1IGZA 2RHPA 1ZAQA
chains in the Genus database with same CATH superfamily
5KIRA 3P5BL 3Q7DA 3LN1A 1APQA 2W2NE 1LMMA 2EI6B 4M10A 1NPEB 1EQHA 1HAFA 2YGQA 2FLGA 4XL1A 2B7DL 1ATEA 5IKRA 2P3TA 1PRHA 1CQEA 1NT0A 1IQJL 4X8UL 2VVVL 3KRKA 1DX5I 1V1HA 1IQHL 5CISA 3TBDA 5JBCE 1F0SB 2VVUL 1JV2B 2Y5GL 2XBVL 3IITB 1IQNL 1TLEA 3FFGL 1DDXA 4ISHL 2VVCK 3H5CB 2P3FL 3U73A 3NTBA 4D0FA 3GCWE 4TGFA 2XC4L 3Q3KB 4ZXXL 3SOVA 3QMOA 4BDXA 4MMYB 2CJIB 4ZXYL 1MQ6L 3HPTA 4AQTA 2Y80B 3EGFA 1WU1B 2HOXA 4YT6L 1ATBA 2JKHL 2Y7ZB 2FLRL 2HORA 2JJLA 2EI7B 1EZQB 1I0UA 2P93L 2W2ME 1DQBA 1YGCL 2P94L 4X8TL 2J4IB 1DIYA 3HS6A 1IQEL 1X7AL 4BTTA 3HO3A 4Y71B 3N8WA 5CKQA 4BTIA 1ATDA 2KL7A 1YUGA 1YUKB 4YZUB 1NZIA 2WG3C 1K37A 1QFKL 1LPZA 1PGEA 4GU4A 4RRXA 1M1XB 1HCGB 5IKVA 2WPKE 1FAXL 3N8ZA 2Y82B 1KLJL 3CFWA 4RRZA 3NT1A 2Y81B 5L30L 1G2MB 2BQWA 1FFMA 1IGXA 4CSYA 1NFUB 4JZEL 1WHFA 2G00L 2I9BA 1EBVA 3M36L 1IOEL 2P3UA 4JYUL 3GISX 1G2LB 1FJSL 2K2SB 1EPGA 1MOXC 3F1SB 3SW2A 2NPRA 3HS5A 3HO5A 2XBWL 4BXWA 2EI8B 1LMJA 1XFEA 4C16A 1F7EA 3BT1A 1FE2A 1GK5A 2BOXA 5IKTA 4RRWA 1KKEA 4X8VL 1EMOA 2XBYL 3LIWB 3SOBB 1W8BL 2Y7XB 4BTUA 1G1RA 1YO8A 6COXA 2KNIA 1PXXA 1YUFA 2VRSA 2WPME 1P9JA 1APOA 3LAQA 1EQGA 1COUA 2P3FN 2WFTA 2I9AA 4JZDL 2FD6A 3N8YB 2WYGB 4RRYA 1N1IA 1FSBA 2W3IB 2VJ3A 4Y7AB 2W2QE 1ATAA 2P95L 2VH0B 3ENSA 4RUTA 2WPJE 2Y38A 4O02B 3MQEA 1IQFL 1RFNB 2OYUP 2FLBL 2VWMK 2F9BL 4CUFA 1QIUA 2UWOB 2XC0L 2M74A 1DVAL 2J94B 3ELAL 4BDWA 1P0SL 2OYEP 1JBUL 2FZZL 5FDQA 1O5DL 2P16L 3CA7A 1W7XL 1EPIA 2W2OE 4E1GA 1Z6EL 3POYA 1XKBA 1IOXA 1UZPA 3LTGD 3TK6B 2WPIE 1IVOC 1UZJA 4OTYA 2J38B 1L3YA 3OLTA 1Q4GA 1NQLB 2J34B 2WZPP 3N8XA 4ISIL 5IKQA 4CUDA 1KSNB 1F0RB 1HT8A 3V65B 4NG9L 3N8YA 1PFXL 4XBMA 4XLWA 2RA0L 2UWLB 2AYLA 2MGRA 3ZYJB 1CEJA 1OB1C 4JZFL 1U67A 1NFYB 1L5GB 3KK6A 3R05A 3M37L 4CUEA 1CVUA 1N7DA 3NJPC 4X8SL 1B9WA 4NGAL 1SZBA 5CKMA 5I46L 3MDLA 4LMFA 2XC5L 4RS0A 1IQKL 1MQ5L 1KLIL 3KQBL 2Q1JB 2Y5FL 5F19A 5JVYA 3OLUA 3CS7L 5E8DA 3S6XA 1NFWB 4OTJA 2W3KB 4NA9L 4LORA 4ZHAB 2RNLA 1KIGL 2UWPB 2WFXB 1PTHA 3SOQA 4D90A 4D0EA 1G1QA 3KCGL 3RR3A 2PR3B 2GD4A 1ADXA 1EPHA 2BQ7A 1EGFA 2ADXA 4A94C 1URKA 3TZIA 3TK5B 5JW1A 1XDTR 2W26B 3HO4A 1IP0A 2WG4B 5JVZA 4ZH8B 3LC3B 2K2TA 4O1ZA 2H9EL 4M11A 1G1TA 3QCWA 3HS7A 3KQCL 3TGFA 5KN5C 2P28B 1J9CL 5EGMB 3LC5B 5L2YL 1LPKA 1EPJA 1HX2A 1LK9A 2W86A 3V64C 4YT7L 4MMZB 4ZAEB 3DEMA 2Y5HL 4BXSA 2BSFA 3ASIA 1HT5A 4Y79B 1HRFA 2J2UB 3IJEB 5JB9E 2TGFA 5JB8E 1TOZA 3PGHA 1FF7A 5COXA 3K9XA 3C9AC 1C5MF 2VH6B 2BOUA 4Y6DB 1V1IA 1NFXB 1IQIL 2MGPA 5JBAE 2BT7A 4COXA 2W2PE 1K36A 1HZ8A 2KB9A 3GCXE 2BQ6A 4MMXB 5K0HB 4A7IA 1CVWL 4Z0LA 1Z6CA 2P26A 3F6UL 1HJ7A 1IQGL 2VWOL 3KQDL 3TH3L 1EAIC 2BOKL 3FCSB 3N8VA 2PUQL 1TPGA 5F1AA 2BZ6L 2J95B 3FBYA 1XKAL 2DDUA 2KV4A 1A3PA 3ZYGA 1CCFA 1AUTL 2PHBB 1U8CB 2H9EC 1UZKA 1F7MA 1LQDA 5CKNA 3U7UG 5JBBE 3ZYIB 1IQLL 4G1MB 3LN0A 3BPSE 4Y7BB 3KL6B 2YGOA 3CENL 2BT8A 2BMGA 1FAKL 1LPGA 4GU3A 2BOHA 4Y76B 2VWLL 1CCVA 2VWNL 4Z0KB 2BO2A 2WPHE 3NTGA 3LTFB 2XBXL 1BF9A 1EMNA 2YGPA 5L2ZL 3QH0A 2MHPA 1HAEA 1IJQA 1CX2A 2D1JB 1HREA 1JL9A 1IQML 1UZQA 1WHEA 2WYJB 1G1SA 2WPLE 4Z6AL 3N8WB 4FM5A 1V3XB 3KQEL 3BT2A 4JYVL 1KLOA 4PH9A 1IGZA 2RHPA 1ZAQA
chains in the Genus database with same CATH topology
5KIRA 3P5BL 3Q7DA 3LN1A 1APQA 2W2NE 1LMMA 2EI6B 4M10A 1NPEB 1EQHA 1HAFA 2YGQA 2FLGA 4XL1A 2B7DL 1ATEA 5IKRA 2P3TA 1PRHA 1CQEA 1NT0A 1IQJL 4X8UL 2VVVL 3KRKA 1DX5I 1IQHL 5CISA 3TBDA 5JBCE 1F0SB 2VVUL 1JV2B 2Y5GL 2XBVL 3IITB 1IQNL 1TLEA 3FFGL 1DDXA 4ISHL 2VVCK 3H5CB 2P3FL 3U73A 3NTBA 4D0FA 3GCWE 4TGFA 2XC4L 3Q3KB 4ZXXL 3SOVA 3QMOA 4BDXA 4MMYB 2CJIB 4ZXYL 1MQ6L 3HPTA 4AQTA 2Y80B 3EGFA 1WU1B 4YT6L 1ATBA 2JKHL 2Y7ZB 2FLRL 2EI7B 1EZQB 1I0UA 2P93L 2W2ME 1DQBA 1YGCL 2P94L 4X8TL 2J4IB 1DIYA 3HS6A 1IQEL 1X7AL 4BTTA 3HO3A 4Y71B 3N8WA 5CKQA 4BTIA 1ATDA 2KL7A 1YUGA 1YUKB 4YZUB 1NZIA 2WG3C 1K37A 1QFKL 1LPZA 1PGEA 4RRXA 1M1XB 1HCGB 5IKVA 2WPKE 1FAXL 3N8ZA 2Y82B 1KLJL 3CFWA 4RRZA 3NT1A 2Y81B 5L30L 1G2MB 2BQWA 1FFMA 1IGXA 4CSYA 1NFUB 4JZEL 1WHFA 2G00L 2I9BA 1EBVA 3M36L 1IOEL 2P3UA 4JYUL 3GISX 1G2LB 1FJSL 2K2SB 1EPGA 1MOXC 3F1SB 3SW2A 2NPRA 3HS5A 3HO5A 2XBWL 4BXWA 2EI8B 1LMJA 1XFEA 4C16A 1F7EA 3BT1A 1FE2A 1GK5A 2BOXA 5IKTA 4RRWA 4X8VL 1EMOA 2XBYL 3LIWB 3SOBB 1W8BL 2Y7XB 4BTUA 1G1RA 1YO8A 6COXA 2KNIA 1PXXA 1YUFA 2WPME 1P9JA 1APOA 3LAQA 1EQGA 1COUA 2P3FN 2WFTA 2I9AA 4JZDL 2FD6A 3N8YB 2WYGB 4RRYA 1N1IA 1FSBA 2W3IB 2VJ3A 4Y7AB 2W2QE 1ATAA 2P95L 2VH0B 3ENSA 4RUTA 2WPJE 2Y38A 4O02B 3MQEA 1IQFL 1RFNB 2OYUP 2FLBL 2VWMK 2F9BL 4CUFA 2UWOB 2XC0L 2M74A 1DVAL 2J94B 3ELAL 4BDWA 1P0SL 2OYEP 1JBUL 2FZZL 5FDQA 1O5DL 2P16L 3CA7A 1W7XL 1EPIA 2W2OE 4E1GA 1Z6EL 3POYA 1XKBA 1IOXA 1UZPA 3LTGD 3TK6B 2WPIE 1IVOC 1UZJA 4OTYA 2J38B 1L3YA 3OLTA 1Q4GA 1NQLB 2J34B 2WZPP 3N8XA 4ISIL 5IKQA 4CUDA 1KSNB 1F0RB 1HT8A 3V65B 4NG9L 3N8YA 1PFXL 4XBMA 4XLWA 2RA0L 2UWLB 2AYLA 2MGRA 3ZYJB 1CEJA 1OB1C 4JZFL 1U67A 1NFYB 1L5GB 3KK6A 3R05A 3M37L 4CUEA 1CVUA 1N7DA 3NJPC 4X8SL 1B9WA 4NGAL 1SZBA 5CKMA 5I46L 3MDLA 4LMFA 2XC5L 4RS0A 1IQKL 1MQ5L 1KLIL 3KQBL 2Q1JB 2Y5FL 5F19A 5JVYA 3OLUA 3CS7L 5E8DA 3S6XA 1NFWB 4OTJA 2W3KB 4NA9L 4LORA 4ZHAB 2RNLA 1KIGL 2UWPB 2WFXB 1PTHA 3SOQA 4D90A 4D0EA 1G1QA 3KCGL 3RR3A 2PR3B 2GD4A 1ADXA 1EPHA 2BQ7A 1EGFA 2ADXA 4A94C 1URKA 3TZIA 3TK5B 5JW1A 1XDTR 2W26B 3HO4A 1IP0A 2WG4B 5JVZA 4ZH8B 3LC3B 2K2TA 4O1ZA 2H9EL 4M11A 1G1TA 3QCWA 3HS7A 3KQCL 3TGFA 5KN5C 2P28B 1J9CL 5EGMB 3LC5B 5L2YL 1LPKA 1EPJA 1HX2A 2W86A 3V64C 4YT7L 4MMZB 4ZAEB 3DEMA 2Y5HL 4BXSA 3ASIA 1HT5A 4Y79B 1HRFA 2J2UB 3IJEB 5JB9E 2TGFA 5JB8E 1TOZA 3PGHA 1FF7A 5COXA 3K9XA 3C9AC 1C5MF 2VH6B 2BOUA 4Y6DB 1NFXB 1IQIL 2MGPA 5JBAE 4COXA 2W2PE 1K36A 1HZ8A 2KB9A 3GCXE 2BQ6A 4MMXB 5K0HB 4A7IA 1CVWL 4Z0LA 1Z6CA 2P26A 3F6UL 1HJ7A 1IQGL 2VWOL 3KQDL 3TH3L 1EAIC 2BOKL 3FCSB 3N8VA 2PUQL 1TPGA 5F1AA 2BZ6L 2J95B 3FBYA 1XKAL 2DDUA 2KV4A 1A3PA 3ZYGA 1CCFA 1AUTL 2PHBB 1U8CB 2H9EC 1UZKA 1F7MA 1LQDA 5CKNA 3U7UG 5JBBE 3ZYIB 1IQLL 4G1MB 3LN0A 3BPSE 4Y7BB 3KL6B 2YGOA 3CENL 2BMGA 1FAKL 1LPGA 2BOHA 4Y76B 2VWLL 1CCVA 2VWNL 4Z0KB 2BO2A 2WPHE 3NTGA 3LTFB 2XBXL 1BF9A 1EMNA 2YGPA 5L2ZL 3QH0A 2MHPA 1HAEA 1IJQA 1CX2A 2D1JB 1HREA 1JL9A 1IQML 1UZQA 1WHEA 2WYJB 1G1SA 2WPLE 4Z6AL 3N8WB 4FM5A 1V3XB 3KQEL 3BT2A 4JYVL 1KLOA 4PH9A 1IGZA 2RHPA 1ZAQA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5KIR A;  3P5B L;  3Q7D A;  3LN1 A;  1APQ A;  2W2N E;  2EI6 B;  4M10 A;  1NPE B;  1EQH A;  1HAF A;  2FLG A;  4XL1 A;  2B7D L;  1ATE A;  5IKR A;  2P3T A;  1PRH A;  1CQE A;  1NT0 A;  1IQJ L;  4X8U L;  2VVV L;  3KRK A;  1DX5 I;  1IQH L;  5CIS A;  3TBD A;  5JBC E;  1F0S B;  2VVU L;  1JV2 B;  2Y5G L;  2XBV L;  3IIT B;  1IQN L;  1TLE A;  3FFG L;  1DDX A;  4ISH L;  2VVC K;  3H5C B;  2P3F L;  3U73 A;  3NTB A;  4D0F A;  3GCW E;  4TGF A;  2XC4 L;  3Q3K B;  4ZXX L;  3SOV A;  3QMO A;  4BDX A;  4MMY B;  2CJI B;  4ZXY L;  1MQ6 L;  3HPT A;  4AQT A;  2Y80 B;  3EGF A;  1WU1 B;  4YT6 L;  1ATB A;  2JKH L;  2Y7Z B;  2FLR L;  2EI7 B;  1EZQ B;  1I0U A;  2P93 L;  2W2M E;  1DQB A;  1YGC L;  2P94 L;  4X8T L;  2J4I B;  1DIY A;  3HS6 A;  1IQE L;  1X7A L;  4BTT A;  3HO3 A;  4Y71 B;  3N8W A;  5CKQ A;  4BTI A;  1ATD A;  2KL7 A;  1YUG A;  1YUK B;  4YZU B;  1NZI A;  2WG3 C;  1K37 A;  1QFK L;  1LPZ A;  1PGE A;  4RRX A;  1M1X B;  1HCG B;  5IKV A;  2WPK E;  1FAX L;  3N8Z A;  2Y82 B;  1KLJ L;  3CFW A;  4RRZ A;  3NT1 A;  2Y81 B;  5L30 L;  1G2M B;  2BQW A;  1FFM A;  1IGX A;  4CSY A;  1NFU B;  4JZE L;  1WHF A;  2G00 L;  2I9B A;  1EBV A;  3M36 L;  1IOE L;  2P3U A;  4JYU L;  3GIS X;  1G2L B;  1FJS L;  2K2S B;  1EPG A;  1MOX C;  3F1S B;  3SW2 A;  2NPR A;  3HS5 A;  3HO5 A;  2XBW L;  4BXW A;  2EI8 B;  1LMJ A;  1XFE A;  4C16 A;  1F7E A;  3BT1 A;  1FE2 A;  1GK5 A;  2BOX A;  5IKT A;  4RRW A;  4X8V L;  1EMO A;  2XBY L;  3LIW B;  3SOB B;  1W8B L;  2Y7X B;  4BTU A;  1G1R A;  1YO8 A;  6COX A;  1PXX A;  1YUF A;  2WPM E;  1P9J A;  1APO A;  3LAQ A;  1EQG A;  1COU A;  2P3F N;  2WFT A;  2I9A A;  4JZD L;  2FD6 A;  3N8Y B;  2WYG B;  4RRY A;  1N1I A;  1FSB A;  2W3I B;  2VJ3 A;  4Y7A B;  2W2Q E;  1ATA A;  2P95 L;  2VH0 B;  3ENS A;  4RUT A;  2WPJ E;  2Y38 A;  4O02 B;  3MQE A;  1IQF L;  1RFN B;  2OYU P;  2FLB L;  2VWM K;  2F9B L;  4CUF A;  2UWO B;  2XC0 L;  2M74 A;  1DVA L;  2J94 B;  3ELA L;  4BDW A;  1P0S L;  2OYE P;  1JBU L;  2FZZ L;  5FDQ A;  1O5D L;  2P16 L;  3CA7 A;  1W7X L;  1EPI A;  2W2O E;  4E1G A;  1Z6E L;  3POY A;  1XKB A;  1IOX A;  1UZP A;  3LTG D;  3TK6 B;  2WPI E;  1IVO C;  1UZJ A;  4OTY A;  2J38 B;  1L3Y A;  3OLT A;  1Q4G A;  1NQL B;  2J34 B;  3N8X A;  4ISI L;  5IKQ A;  4CUD A;  1KSN B;  1F0R B;  1HT8 A;  3V65 B;  4NG9 L;  3N8Y A;  1PFX L;  4XBM A;  4XLW A;  2RA0 L;  2UWL B;  2AYL A;  2MGR A;  3ZYJ B;  1CEJ A;  1OB1 C;  4JZF L;  1U67 A;  1NFY B;  1L5G B;  3KK6 A;  3R05 A;  3M37 L;  4CUE A;  1CVU A;  1N7D A;  3NJP C;  4X8S L;  1B9W A;  4NGA L;  1SZB A;  5CKM A;  5I46 L;  3MDL A;  4LMF A;  2XC5 L;  4RS0 A;  1IQK L;  1MQ5 L;  1KLI L;  3KQB L;  2Q1J B;  2Y5F L;  5F19 A;  5JVY A;  3OLU A;  3CS7 L;  5E8D A;  1NFW B;  4OTJ A;  2W3K B;  4NA9 L;  4LOR A;  4ZHA B;  2RNL A;  1KIG L;  2UWP B;  2WFX B;  1PTH A;  3SOQ A;  4D90 A;  4D0E A;  1G1Q A;  3KCG L;  3RR3 A;  2PR3 B;  2GD4 A;  1ADX A;  1EPH A;  2BQ7 A;  1EGF A;  2ADX A;  1URK A;  3TZI A;  3TK5 B;  5JW1 A;  1XDT R;  2W26 B;  3HO4 A;  1IP0 A;  2WG4 B;  5JVZ A;  4ZH8 B;  3LC3 B;  2K2T A;  4O1Z A;  2H9E L;  4M11 A;  1G1T A;  3QCW A;  3HS7 A;  3KQC L;  3TGF A;  5KN5 C;  2P28 B;  1J9C L;  5EGM B;  3LC5 B;  5L2Y L;  1LPK A;  1EPJ A;  1HX2 A;  2W86 A;  3V64 C;  4YT7 L;  4MMZ B;  4ZAE B;  3DEM A;  2Y5H L;  4BXS A;  3ASI A;  1HT5 A;  4Y79 B;  1HRF A;  2J2U B;  3IJE B;  5JB9 E;  2TGF A;  5JB8 E;  1TOZ A;  3PGH A;  1FF7 A;  5COX A;  3K9X A;  3C9A C;  1C5M F;  2VH6 B;  2BOU A;  4Y6D B;  1NFX B;  1IQI L;  2MGP A;  5JBA E;  4COX A;  2W2P E;  1K36 A;  1HZ8 A;  2KB9 A;  3GCX E;  2BQ6 A;  4MMX B;  5K0H B;  4A7I A;  1CVW L;  4Z0L A;  1Z6C A;  2P26 A;  3F6U L;  1HJ7 A;  1IQG L;  2VWO L;  3KQD L;  3TH3 L;  1EAI C;  2BOK L;  3FCS B;  3N8V A;  2PUQ L;  1TPG A;  5F1A A;  2BZ6 L;  2J95 B;  3FBY A;  1XKA L;  2DDU A;  2KV4 A;  1A3P A;  3ZYG A;  1CCF A;  1AUT L;  2PHB B;  1U8C B;  1UZK A;  1F7M A;  1LQD A;  5CKN A;  3U7U G;  5JBB E;  3ZYI B;  1IQL L;  4G1M B;  3LN0 A;  3BPS E;  4Y7B B;  3KL6 B;  2YGO A;  3CEN L;  2BMG A;  1FAK L;  1LPG A;  2BOH A;  4Y76 B;  2VWL L;  1CCV A;  2VWN L;  4Z0K B;  2BO2 A;  2WPH E;  3NTG A;  3LTF B;  2XBX L;  1BF9 A;  1EMN A;  2YGP A;  5L2Z L;  3QH0 A;  2MHP A;  1HAE A;  1IJQ A;  1CX2 A;  2D1J B;  1HRE A;  1JL9 A;  1IQM L;  1UZQ A;  1WHE A;  2WYJ B;  1G1S A;  2WPL E;  4Z6A L;  3N8W B;  4FM5 A;  1V3X B;  3KQE L;  3BT2 A;  4JYV L;  1KLO A;  4PH9 A;  1IGZ A;  2RHP A;  1ZAQ A; 
#chains in the Genus database with same CATH topology
 5KIR A;  3P5B L;  3Q7D A;  3LN1 A;  1APQ A;  2W2N E;  1LMM A;  2EI6 B;  4M10 A;  1NPE B;  1EQH A;  1HAF A;  2YGQ A;  2FLG A;  4XL1 A;  2B7D L;  1ATE A;  5IKR A;  2P3T A;  1PRH A;  1CQE A;  1NT0 A;  1IQJ L;  4X8U L;  2VVV L;  3KRK A;  1DX5 I;  1V1H A;  1IQH L;  5CIS A;  3TBD A;  5JBC E;  1F0S B;  2VVU L;  1JV2 B;  2Y5G L;  2XBV L;  3IIT B;  1IQN L;  1TLE A;  3FFG L;  1DDX A;  4ISH L;  2VVC K;  3H5C B;  2P3F L;  3U73 A;  3NTB A;  4D0F A;  3GCW E;  4TGF A;  2XC4 L;  3Q3K B;  4ZXX L;  3SOV A;  3QMO A;  4BDX A;  4MMY B;  2CJI B;  4ZXY L;  1MQ6 L;  3HPT A;  4AQT A;  2Y80 B;  3EGF A;  1WU1 B;  2HOX A;  4YT6 L;  1ATB A;  2JKH L;  2Y7Z B;  2FLR L;  2HOR A;  2JJL A;  2EI7 B;  1EZQ B;  1I0U A;  2P93 L;  2W2M E;  1DQB A;  1YGC L;  2P94 L;  4X8T L;  2J4I B;  1DIY A;  3HS6 A;  1IQE L;  1X7A L;  4BTT A;  3HO3 A;  4Y71 B;  3N8W A;  5CKQ A;  4BTI A;  1ATD A;  2KL7 A;  1YUG A;  1YUK B;  4YZU B;  1NZI A;  2WG3 C;  1K37 A;  1QFK L;  1LPZ A;  1PGE A;  4GU4 A;  4RRX A;  1M1X B;  1HCG B;  5IKV A;  2WPK E;  1FAX L;  3N8Z A;  2Y82 B;  1KLJ L;  3CFW A;  4RRZ A;  3NT1 A;  2Y81 B;  5L30 L;  1G2M B;  2BQW A;  1FFM A;  1IGX A;  4CSY A;  1NFU B;  4JZE L;  1WHF A;  2G00 L;  2I9B A;  1EBV A;  3M36 L;  1IOE L;  2P3U A;  4JYU L;  3GIS X;  1G2L B;  1FJS L;  2K2S B;  1EPG A;  1MOX C;  3F1S B;  3SW2 A;  2NPR A;  3HS5 A;  3HO5 A;  2XBW L;  4BXW A;  2EI8 B;  1LMJ A;  1XFE A;  4C16 A;  1F7E A;  3BT1 A;  1FE2 A;  1GK5 A;  2BOX A;  5IKT A;  4RRW A;  1KKE A;  4X8V L;  1EMO A;  2XBY L;  3LIW B;  3SOB B;  1W8B L;  2Y7X B;  4BTU A;  1G1R A;  1YO8 A;  6COX A;  2KNI A;  1PXX A;  1YUF A;  2VRS A;  2WPM E;  1P9J A;  1APO A;  3LAQ A;  1EQG A;  1COU A;  2P3F N;  2WFT A;  2I9A A;  4JZD L;  2FD6 A;  3N8Y B;  2WYG B;  4RRY A;  1N1I A;  1FSB A;  2W3I B;  2VJ3 A;  4Y7A B;  2W2Q E;  1ATA A;  2P95 L;  2VH0 B;  3ENS A;  4RUT A;  2WPJ E;  2Y38 A;  4O02 B;  3MQE A;  1IQF L;  1RFN B;  2OYU P;  2FLB L;  2VWM K;  2F9B L;  4CUF A;  1QIU A;  2UWO B;  2XC0 L;  2M74 A;  1DVA L;  2J94 B;  3ELA L;  4BDW A;  1P0S L;  2OYE P;  1JBU L;  2FZZ L;  5FDQ A;  1O5D L;  2P16 L;  3CA7 A;  1W7X L;  1EPI A;  2W2O E;  4E1G A;  1Z6E L;  3POY A;  1XKB A;  1IOX A;  1UZP A;  3LTG D;  3TK6 B;  2WPI E;  1IVO C;  1UZJ A;  4OTY A;  2J38 B;  1L3Y A;  3OLT A;  1Q4G A;  1NQL B;  2J34 B;  2WZP P;  3N8X A;  4ISI L;  5IKQ A;  4CUD A;  1KSN B;  1F0R B;  1HT8 A;  3V65 B;  4NG9 L;  3N8Y A;  1PFX L;  4XBM A;  4XLW A;  2RA0 L;  2UWL B;  2AYL A;  2MGR A;  3ZYJ B;  1CEJ A;  1OB1 C;  4JZF L;  1U67 A;  1NFY B;  1L5G B;  3KK6 A;  3R05 A;  3M37 L;  4CUE A;  1CVU A;  1N7D A;  3NJP C;  4X8S L;  1B9W A;  4NGA L;  1SZB A;  5CKM A;  5I46 L;  3MDL A;  4LMF A;  2XC5 L;  4RS0 A;  1IQK L;  1MQ5 L;  1KLI L;  3KQB L;  2Q1J B;  2Y5F L;  5F19 A;  5JVY A;  3OLU A;  3CS7 L;  5E8D A;  3S6X A;  1NFW B;  4OTJ A;  2W3K B;  4NA9 L;  4LOR A;  4ZHA B;  2RNL A;  1KIG L;  2UWP B;  2WFX B;  1PTH A;  3SOQ A;  4D90 A;  4D0E A;  1G1Q A;  3KCG L;  3RR3 A;  2PR3 B;  2GD4 A;  1ADX A;  1EPH A;  2BQ7 A;  1EGF A;  2ADX A;  4A94 C;  1URK A;  3TZI A;  3TK5 B;  5JW1 A;  1XDT R;  2W26 B;  3HO4 A;  1IP0 A;  2WG4 B;  5JVZ A;  4ZH8 B;  3LC3 B;  2K2T A;  4O1Z A;  2H9E L;  4M11 A;  1G1T A;  3QCW A;  3HS7 A;  3KQC L;  3TGF A;  5KN5 C;  2P28 B;  1J9C L;  5EGM B;  3LC5 B;  5L2Y L;  1LPK A;  1EPJ A;  1HX2 A;  1LK9 A;  2W86 A;  3V64 C;  4YT7 L;  4MMZ B;  4ZAE B;  3DEM A;  2Y5H L;  4BXS A;  2BSF A;  3ASI A;  1HT5 A;  4Y79 B;  1HRF A;  2J2U B;  3IJE B;  5JB9 E;  2TGF A;  5JB8 E;  1TOZ A;  3PGH A;  1FF7 A;  5COX A;  3K9X A;  3C9A C;  1C5M F;  2VH6 B;  2BOU A;  4Y6D B;  1V1I A;  1NFX B;  1IQI L;  2MGP A;  5JBA E;  2BT7 A;  4COX A;  2W2P E;  1K36 A;  1HZ8 A;  2KB9 A;  3GCX E;  2BQ6 A;  4MMX B;  5K0H B;  4A7I A;  1CVW L;  4Z0L A;  1Z6C A;  2P26 A;  3F6U L;  1HJ7 A;  1IQG L;  2VWO L;  3KQD L;  3TH3 L;  1EAI C;  2BOK L;  3FCS B;  3N8V A;  2PUQ L;  1TPG A;  5F1A A;  2BZ6 L;  2J95 B;  3FBY A;  1XKA L;  2DDU A;  2KV4 A;  1A3P A;  3ZYG A;  1CCF A;  1AUT L;  2PHB B;  1U8C B;  2H9E C;  1UZK A;  1F7M A;  1LQD A;  5CKN A;  3U7U G;  5JBB E;  3ZYI B;  1IQL L;  4G1M B;  3LN0 A;  3BPS E;  4Y7B B;  3KL6 B;  2YGO A;  3CEN L;  2BT8 A;  2BMG A;  1FAK L;  1LPG A;  4GU3 A;  2BOH A;  4Y76 B;  2VWL L;  1CCV A;  2VWN L;  4Z0K B;  2BO2 A;  2WPH E;  3NTG A;  3LTF B;  2XBX L;  1BF9 A;  1EMN A;  2YGP A;  5L2Z L;  3QH0 A;  2MHP A;  1HAE A;  1IJQ A;  1CX2 A;  2D1J B;  1HRE A;  1JL9 A;  1IQM L;  1UZQ A;  1WHE A;  2WYJ B;  1G1S A;  2WPL E;  4Z6A L;  3N8W B;  4FM5 A;  1V3X B;  3KQE L;  3BT2 A;  4JYV L;  1KLO A;  4PH9 A;  1IGZ A;  2RHP A;  1ZAQ A; 
#chains in the Genus database with same CATH homology
 5KIR A;  3P5B L;  3Q7D A;  3LN1 A;  1APQ A;  2W2N E;  1LMM A;  2EI6 B;  4M10 A;  1NPE B;  1EQH A;  1HAF A;  2YGQ A;  2FLG A;  4XL1 A;  2B7D L;  1ATE A;  5IKR A;  2P3T A;  1PRH A;  1CQE A;  1NT0 A;  1IQJ L;  4X8U L;  2VVV L;  3KRK A;  1DX5 I;  1IQH L;  5CIS A;  3TBD A;  5JBC E;  1F0S B;  2VVU L;  1JV2 B;  2Y5G L;  2XBV L;  3IIT B;  1IQN L;  1TLE A;  3FFG L;  1DDX A;  4ISH L;  2VVC K;  3H5C B;  2P3F L;  3U73 A;  3NTB A;  4D0F A;  3GCW E;  4TGF A;  2XC4 L;  3Q3K B;  4ZXX L;  3SOV A;  3QMO A;  4BDX A;  4MMY B;  2CJI B;  4ZXY L;  1MQ6 L;  3HPT A;  4AQT A;  2Y80 B;  3EGF A;  1WU1 B;  4YT6 L;  1ATB A;  2JKH L;  2Y7Z B;  2FLR L;  2EI7 B;  1EZQ B;  1I0U A;  2P93 L;  2W2M E;  1DQB A;  1YGC L;  2P94 L;  4X8T L;  2J4I B;  1DIY A;  3HS6 A;  1IQE L;  1X7A L;  4BTT A;  3HO3 A;  4Y71 B;  3N8W A;  5CKQ A;  4BTI A;  1ATD A;  2KL7 A;  1YUG A;  1YUK B;  4YZU B;  1NZI A;  2WG3 C;  1K37 A;  1QFK L;  1LPZ A;  1PGE A;  4RRX A;  1M1X B;  1HCG B;  5IKV A;  2WPK E;  1FAX L;  3N8Z A;  2Y82 B;  1KLJ L;  3CFW A;  4RRZ A;  3NT1 A;  2Y81 B;  5L30 L;  1G2M B;  2BQW A;  1FFM A;  1IGX A;  4CSY A;  1NFU B;  4JZE L;  1WHF A;  2G00 L;  2I9B A;  1EBV A;  3M36 L;  1IOE L;  2P3U A;  4JYU L;  3GIS X;  1G2L B;  1FJS L;  2K2S B;  1EPG A;  1MOX C;  3F1S B;  3SW2 A;  2NPR A;  3HS5 A;  3HO5 A;  2XBW L;  4BXW A;  2EI8 B;  1LMJ A;  1XFE A;  4C16 A;  1F7E A;  3BT1 A;  1FE2 A;  1GK5 A;  2BOX A;  5IKT A;  4RRW A;  4X8V L;  1EMO A;  2XBY L;  3LIW B;  3SOB B;  1W8B L;  2Y7X B;  4BTU A;  1G1R A;  1YO8 A;  6COX A;  2KNI A;  1PXX A;  1YUF A;  2WPM E;  1P9J A;  1APO A;  3LAQ A;  1EQG A;  1COU A;  2P3F N;  2WFT A;  2I9A A;  4JZD L;  2FD6 A;  3N8Y B;  2WYG B;  4RRY A;  1N1I A;  1FSB A;  2W3I B;  2VJ3 A;  4Y7A B;  2W2Q E;  1ATA A;  2P95 L;  2VH0 B;  3ENS A;  4RUT A;  2WPJ E;  2Y38 A;  4O02 B;  3MQE A;  1IQF L;  1RFN B;  2OYU P;  2FLB L;  2VWM K;  2F9B L;  4CUF A;  2UWO B;  2XC0 L;  2M74 A;  1DVA L;  2J94 B;  3ELA L;  4BDW A;  1P0S L;  2OYE P;  1JBU L;  2FZZ L;  5FDQ A;  1O5D L;  2P16 L;  3CA7 A;  1W7X L;  1EPI A;  2W2O E;  4E1G A;  1Z6E L;  3POY A;  1XKB A;  1IOX A;  1UZP A;  3LTG D;  3TK6 B;  2WPI E;  1IVO C;  1UZJ A;  4OTY A;  2J38 B;  1L3Y A;  3OLT A;  1Q4G A;  1NQL B;  2J34 B;  2WZP P;  3N8X A;  4ISI L;  5IKQ A;  4CUD A;  1KSN B;  1F0R B;  1HT8 A;  3V65 B;  4NG9 L;  3N8Y A;  1PFX L;  4XBM A;  4XLW A;  2RA0 L;  2UWL B;  2AYL A;  2MGR A;  3ZYJ B;  1CEJ A;  1OB1 C;  4JZF L;  1U67 A;  1NFY B;  1L5G B;  3KK6 A;  3R05 A;  3M37 L;  4CUE A;  1CVU A;  1N7D A;  3NJP C;  4X8S L;  1B9W A;  4NGA L;  1SZB A;  5CKM A;  5I46 L;  3MDL A;  4LMF A;  2XC5 L;  4RS0 A;  1IQK L;  1MQ5 L;  1KLI L;  3KQB L;  2Q1J B;  2Y5F L;  5F19 A;  5JVY A;  3OLU A;  3CS7 L;  5E8D A;  3S6X A;  1NFW B;  4OTJ A;  2W3K B;  4NA9 L;  4LOR A;  4ZHA B;  2RNL A;  1KIG L;  2UWP B;  2WFX B;  1PTH A;  3SOQ A;  4D90 A;  4D0E A;  1G1Q A;  3KCG L;  3RR3 A;  2PR3 B;  2GD4 A;  1ADX A;  1EPH A;  2BQ7 A;  1EGF A;  2ADX A;  4A94 C;  1URK A;  3TZI A;  3TK5 B;  5JW1 A;  1XDT R;  2W26 B;  3HO4 A;  1IP0 A;  2WG4 B;  5JVZ A;  4ZH8 B;  3LC3 B;  2K2T A;  4O1Z A;  2H9E L;  4M11 A;  1G1T A;  3QCW A;  3HS7 A;  3KQC L;  3TGF A;  5KN5 C;  2P28 B;  1J9C L;  5EGM B;  3LC5 B;  5L2Y L;  1LPK A;  1EPJ A;  1HX2 A;  2W86 A;  3V64 C;  4YT7 L;  4MMZ B;  4ZAE B;  3DEM A;  2Y5H L;  4BXS A;  3ASI A;  1HT5 A;  4Y79 B;  1HRF A;  2J2U B;  3IJE B;  5JB9 E;  2TGF A;  5JB8 E;  1TOZ A;  3PGH A;  1FF7 A;  5COX A;  3K9X A;  3C9A C;  1C5M F;  2VH6 B;  2BOU A;  4Y6D B;  1NFX B;  1IQI L;  2MGP A;  5JBA E;  4COX A;  2W2P E;  1K36 A;  1HZ8 A;  2KB9 A;  3GCX E;  2BQ6 A;  4MMX B;  5K0H B;  4A7I A;  1CVW L;  4Z0L A;  1Z6C A;  2P26 A;  3F6U L;  1HJ7 A;  1IQG L;  2VWO L;  3KQD L;  3TH3 L;  1EAI C;  2BOK L;  3FCS B;  3N8V A;  2PUQ L;  1TPG A;  5F1A A;  2BZ6 L;  2J95 B;  3FBY A;  1XKA L;  2DDU A;  2KV4 A;  1A3P A;  3ZYG A;  1CCF A;  1AUT L;  2PHB B;  1U8C B;  2H9E C;  1UZK A;  1F7M A;  1LQD A;  5CKN A;  3U7U G;  5JBB E;  3ZYI B;  1IQL L;  4G1M B;  3LN0 A;  3BPS E;  4Y7B B;  3KL6 B;  2YGO A;  3CEN L;  2BMG A;  1FAK L;  1LPG A;  2BOH A;  4Y76 B;  2VWL L;  1CCV A;  2VWN L;  4Z0K B;  2BO2 A;  2WPH E;  3NTG A;  3LTF B;  2XBX L;  1BF9 A;  1EMN A;  2YGP A;  5L2Z L;  3QH0 A;  2MHP A;  1HAE A;  1IJQ A;  1CX2 A;  2D1J B;  1HRE A;  1JL9 A;  1IQM L;  1UZQ A;  1WHE A;  2WYJ B;  1G1S A;  2WPL E;  4Z6A L;  3N8W B;  4FM5 A;  1V3X B;  3KQE L;  3BT2 A;  4JYV L;  1KLO A;  4PH9 A;  1IGZ A;  2RHP A;  1ZAQ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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