2W3IB

Crystal structure of fxa in complex with 4,4-disubstituted pyrrolidine-1,2-dicarboxamide inhibitor 2
Total Genus 12
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
12
sequence length
51
structure length
50
Chain Sequence
LCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTPYPCGKQTLE
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase
source organism Homo sapiens
publication title Exploration of 4,4-Disubstituted Pyrrolidine-1,2-Dicarboxamides as Potent, Orally Active Factor Xa Inhibitors with Extended Duration of Action.
pubmed doi rcsb
molecule keywords COAGULATION FACTOR X, HEAVY CHAIN
total genus 12
structure length 50
sequence length 51
ec nomenclature ec 3.4.21.6: Coagulation factor Xa.
pdb deposition date 2008-11-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF14670 FXa_inhibition Coagulation Factor Xa inhibitory site
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.25.10 Mainly Beta Ribbon Laminin Laminin 2w3iB00
1PGEA 1IQGL 3F6UL 2XBWL 1PTHA 2P26A 3N8YB 2P16L 2W2OE 1ATEA 1PXXA 4OTJA 1YGCL 2JKHL 3Q7DA 1EBVA 2VVVL 2Y7ZB 1HCGB 1KLOA 2WPME 4JYUL 1APQA 1K36A 3FCSB 1IGZA 3N8WA 3LIWB 2P3TA 5CKQA 2P94L 4Y6DB 4RUTA 1G2LB 1EPHA 1IQLL 2WG4B 1G1TA 4G1MB 1N1IA 1BF9A 3SW2A 1EPGA 2EI6B 4COXA 2Y5HL 4PH9A 4MMXB 1UZPA 1DX5I 2YGOA 4ISHL 3R05A 5JB9E 1NT0A 2FLGA 5JB8E 3LAQA 2KB9A 1IQNL 4XBMA 1HZ8A 1OB1C 1FF7A 1CEJA 4Z0KB 2WPJE 2WPHE 1I0UA 1KLJL 2YGPA 2Y80B 3BT2A 1EPIA 1MQ5L 4NGAL 1JV2B 2W2QE 3M36L 5KN5C 1YUGA 3ZYJB 2Q1JB 2NPRA 1W7XL 3GISX 2P95L 1MQ6L 1UZQA 3MQEA 2WG3C 2VH6B 1HT5A 2W3IB 2RHPA 5FDQA 3SOBB 2F9BL 2CJIB 1DQBA 3F1SB 3H5CB 1CQEA 2J38B 1L5GB 5JBAE 1JL9A 2VWOL 3BPSE 4X8UL 3U73A 1YO8A 3ZYIB 1W8BL 4BTUA 1Z6EL 2FZZL 1G1QA 1HX2A 1MOXC 4Z0LA 3KL6B 1FSBA 2W26B 3DEMA 1DVAL 5L2YL 2PHBB 2WPIE 3BT1A 1IP0A 3N8VA 2TGFA 3HS6A 2B7DL 1UZKA 3HS7A 2UWLB 1A3PA 1ADXA 1FAKL 1FJSL 1PRHA 2WFXB 5I46L 4ZXYL 2W2PE 1UZJA 3NT1A 3KRKA 1U8CB 4BTTA 5JVZA 2I9AA 3KK6A 4CUDA 1G2MB 3LN0A 1EAIC 3V64C 1ATAA 3N8XA 4D90A 3U7UG 3FBYA 3MDLA 3P5BL 4JYVL 1NFYB 4D0FA 5JVYA 4BDXA 4E1GA 2OYEP 1AUTL 4Y7AB 2WYGB 2DDUA 4Z6AL 1TPGA 3PGHA 5CISA 3N8WB 1B9WA 1LPGA 2K2TA 5L2ZL 2WPLE 2PR3B 4TGFA 1V3XB 4CUFA 3ENSA 3KQDL 2AYLA 5JW1A 4XLWA 2P3FN 2XC0L 3SOQA 3LTGD 1HRFA 4XL1A 3OLTA 1IQIL 1IJQA 2XC4L 1J9CL 1PFXL 1WHEA 4LORA 1CCFA 3HO3A 2J95B 1P0SL 2BOHA 2G00L 2XBVL 4RRYA 1F7EA 1DDXA 4MMYB 1XDTR 4ZXXL 4CSYA 4CUEA 1HREA 1HT8A 5K0HB 1KLIL 1IVOC 3LTFB 1IQJL 1K37A 5CKNA 3ELAL 4LMFA 5COXA 3HS5A 4C16A 1F7MA 3NJPC 4JZDL 1WU1B 4Y71B 2FLBL 3CA7A 3V65B 2VWLL 2W2NE 2Y5GL 1F0RB 2BQ6A 3CS7L 4RS0A 1CX2A 4D0EA 5IKVA 4O02B 3FFGL 3EGFA 4AQTA 1EPJA 1IGXA 1NQLB 1FE2A 2VVCK 4ZHAB 1Q4GA 3NTBA 2VWNL 4YT7L 2Y5FL 2BOKL 3HO5A 2UWOB 4OTYA 2VWMK 1EGFA 3IJEB 2J34B 2XBXL 2EI7B 1IQML 2BOUA 3TGFA 1TLEA 1YUKB 1CCVA 1EMNA 4JZEL 2BQ7A 1IQEL 2P28B 3TK6B 5CKMA 4JZFL 2VH0B 4M10A 3SOVA 3ZYGA 1F0SB 1U67A 1EMOA 2MGPA 1LMJA 1YUFA 1G1RA 3OLUA 3LC3B 3N8YA 3Q3KB 4NA9L 1COUA 4RRZA 1KIGL 3HPTA 1Z6CA 1WHFA 2WPKE 4X8VL 4BDWA 2K2SB 4O1ZA 4BTIA 1DIYA 4X8TL 1C5MF 2UWPB 2FLRL 2XBYL 3IITB 4BXWA 4Y7BB 4MMZB 2GD4A 2ADXA 3QH0A 2BO2A 2P3FL 1IQHL 4X8SL 1IQKL 2P93L 5EGMB 1HAFA 3ASIA 4ISIL 2Y7XB 4M11A 5IKQA 5L30L 4ZAEB 1IQFL 1LPZA 2WFTA 4A7IA 5E8DA 1EQHA 5F1AA 4BXSA 1NFWB 2RA0L 3N8ZA 1IOEL 1IOXA 2J4IB 3GCXE 2Y81B 1FFMA 2P3UA 1EQGA 5KIRA 1HAEA 3LC5B 1QFKL 1ATDA 4RRWA 5IKRA 3K9XA 1XKAL 3CFWA 5IKTA 2MHPA 3POYA 1XFEA 2OYUP 2XC5L 4ZH8B 2PUQL 3TK5B 2H9EL 2Y82B 1APOA 1NPEB 2W3KB 3KQCL 4YZUB 3NTGA 1SZBA 3GCWE 1O5DL 1G1SA 5JBCE 1HJ7A 1EZQB 1X7AL 2BZ6L 1NFXB 3LN1A 3TBDA 1FAXL 1CVWL 4NG9L 2Y38A 1ATBA 4YT6L 1P9JA 1JBUL 2VVUL 3KQEL 2BQWA 2EI8B 3C9AC 3TZIA 2J2UB 2FD6A 5JBBE 2RNLA 1LQDA 6COXA 3M37L 2BMGA 2J94B 1CVUA 1LPKA 1KSNB 2VJ3A 2MGRA 2D1JB 3KQBL 1NFUB 4FM5A 4RRXA 5F19A 3QMOA 2I9BA 1GK5A 2M74A 2W2ME 2KL7A 3HO4A 1N7DA 1M1XB 1XKBA 3CENL 3TH3L 2KV4A 4Y79B 1TOZA 1RFNB 2BOXA 1L3YA 4Y76B 1NZIA 3KCGL 2WYJB 3QCWA 1ZAQA 1URKA 3RR3A 2W86A
chains in the Genus database with same CATH superfamily
1PGEA 1IQGL 2BT8A 3F6UL 2XBWL 1PTHA 2P26A 3N8YB 2P16L 2W2OE 1ATEA 1PXXA 4OTJA 1YGCL 2JKHL 3Q7DA 1EBVA 2VVVL 2Y7ZB 1HCGB 1KLOA 2WPME 4JYUL 1APQA 1K36A 3FCSB 1IGZA 3N8WA 3LIWB 2P3TA 5CKQA 2P94L 4Y6DB 4RUTA 1G2LB 1EPHA 1IQLL 2WG4B 1G1TA 4G1MB 1N1IA 1BF9A 2H9EC 3SW2A 1EPGA 2EI6B 4COXA 2Y5HL 4PH9A 4MMXB 1UZPA 1DX5I 2YGOA 4ISHL 3R05A 5JB9E 1NT0A 2FLGA 5JB8E 3LAQA 2KB9A 1IQNL 4XBMA 1HZ8A 1OB1C 1FF7A 1CEJA 4Z0KB 2WPJE 2WPHE 4A94C 1I0UA 1KLJL 2YGPA 2Y80B 3BT2A 1V1IA 1EPIA 1MQ5L 4NGAL 1JV2B 2W2QE 3M36L 5KN5C 1YUGA 3ZYJB 2Q1JB 2NPRA 1W7XL 3GISX 2P95L 1MQ6L 1UZQA 3MQEA 2WG3C 1QIUA 2VH6B 1HT5A 2W3IB 2RHPA 5FDQA 1V1HA 3SOBB 2F9BL 2CJIB 1DQBA 3F1SB 3H5CB 2WZPP 1CQEA 2J38B 1L5GB 5JBAE 1JL9A 2VWOL 3BPSE 4X8UL 3U73A 1YO8A 3ZYIB 1W8BL 4BTUA 1Z6EL 2FZZL 1G1QA 1HX2A 1MOXC 4Z0LA 3KL6B 1FSBA 2W26B 3DEMA 1DVAL 5L2YL 1LMMA 2PHBB 2WPIE 3BT1A 1IP0A 3N8VA 2TGFA 3HS6A 2B7DL 1UZKA 3HS7A 2UWLB 1A3PA 1ADXA 1FAKL 1FJSL 1PRHA 2WFXB 5I46L 2BT7A 2W2PE 4ZXYL 1UZJA 3NT1A 3KRKA 1U8CB 4BTTA 5JVZA 2BSFA 2I9AA 3KK6A 4CUDA 1G2MB 3LN0A 1EAIC 3V64C 1ATAA 3N8XA 4D90A 3U7UG 3FBYA 3MDLA 3P5BL 4JYVL 1NFYB 4D0FA 5JVYA 4BDXA 4E1GA 2OYEP 1AUTL 4Y7AB 2WYGB 2DDUA 4Z6AL 1LK9A 1TPGA 3PGHA 5CISA 1B9WA 1LPGA 2K2TA 3N8WB 5L2ZL 2WPLE 2PR3B 4TGFA 1V3XB 4CUFA 3ENSA 3KQDL 2JJLA 2AYLA 5JW1A 4XLWA 2P3FN 2XC0L 2KNIA 3SOQA 3LTGD 1HRFA 4XL1A 3OLTA 1IQIL 1IJQA 2XC4L 1J9CL 1PFXL 1WHEA 4LORA 1CCFA 3HO3A 2J95B 1P0SL 2BOHA 2G00L 2XBVL 4RRYA 1F7EA 1DDXA 4MMYB 1XDTR 4ZXXL 4CSYA 4CUEA 1HREA 1HT8A 5K0HB 1KLIL 1IVOC 3LTFB 1IQJL 1K37A 5CKNA 3ELAL 4LMFA 5COXA 3HS5A 4C16A 1F7MA 3NJPC 4JZDL 1WU1B 4Y71B 2FLBL 3CA7A 3V65B 2VWLL 2W2NE 2Y5GL 1F0RB 2BQ6A 3CS7L 4RS0A 1CX2A 4D0EA 5IKVA 4O02B 3FFGL 3EGFA 4AQTA 1EPJA 1IGXA 1NQLB 1FE2A 2VVCK 4ZHAB 1Q4GA 3NTBA 2VWNL 4YT7L 2Y5FL 2BOKL 1KKEA 3HO5A 2UWOB 4OTYA 2VWMK 1EGFA 3IJEB 2J34B 2XBXL 2EI7B 1IQML 2BOUA 3TGFA 1TLEA 2HORA 1YUKB 1CCVA 1EMNA 4JZEL 2BQ7A 1IQEL 2P28B 3TK6B 5CKMA 4JZFL 2VH0B 4GU4A 4M10A 3SOVA 3ZYGA 1F0SB 1U67A 1EMOA 2MGPA 1LMJA 1YUFA 1G1RA 3OLUA 3LC3B 3N8YA 3Q3KB 4NA9L 1COUA 4RRZA 1KIGL 3HPTA 1Z6CA 1WHFA 2WPKE 4X8VL 4BDWA 2K2SB 4O1ZA 4BTIA 1DIYA 4X8TL 1C5MF 2UWPB 2FLRL 2VRSA 2XBYL 3IITB 4BXWA 4Y7BB 4MMZB 2GD4A 2ADXA 2HOXA 3QH0A 2BO2A 2P3FL 1IQHL 4X8SL 1IQKL 2P93L 5EGMB 1HAFA 3ASIA 4ISIL 2Y7XB 4M11A 5IKQA 5L30L 4ZAEB 1IQFL 1LPZA 2WFTA 4A7IA 5E8DA 1EQHA 5F1AA 4BXSA 1NFWB 2RA0L 3N8ZA 1IOEL 1IOXA 2J4IB 3GCXE 2Y81B 1FFMA 2P3UA 1EQGA 5KIRA 1HAEA 3LC5B 1QFKL 1ATDA 4RRWA 5IKRA 3K9XA 1XKAL 3CFWA 5IKTA 2MHPA 3POYA 1XFEA 2OYUP 2XC5L 4ZH8B 2PUQL 3TK5B 2H9EL 2Y82B 1APOA 1NPEB 2W3KB 3KQCL 4YZUB 3NTGA 1SZBA 3GCWE 1O5DL 1G1SA 5JBCE 1HJ7A 1EZQB 1X7AL 2BZ6L 1NFXB 3LN1A 3TBDA 1FAXL 1CVWL 4NG9L 2Y38A 1ATBA 4YT6L 1P9JA 1JBUL 2VVUL 3KQEL 2BQWA 2EI8B 3C9AC 3TZIA 2J2UB 2FD6A 4GU3A 5JBBE 2RNLA 1LQDA 6COXA 3M37L 2BMGA 2J94B 1CVUA 1LPKA 1KSNB 2VJ3A 2MGRA 2YGQA 2D1JB 3KQBL 1NFUB 4FM5A 4RRXA 5F19A 3QMOA 2I9BA 1GK5A 2M74A 2W2ME 2KL7A 3HO4A 1N7DA 1M1XB 1XKBA 3CENL 3TH3L 2KV4A 4Y79B 1TOZA 1RFNB 2BOXA 1L3YA 4Y76B 1NZIA 3KCGL 2WYJB 3QCWA 1ZAQA 1URKA 3S6XA 3RR3A 2W86A
chains in the Genus database with same CATH topology
1PGEA 1IQGL 3F6UL 2XBWL 1PTHA 2P26A 3N8YB 2P16L 2W2OE 1ATEA 1PXXA 4OTJA 1YGCL 2JKHL 3Q7DA 1EBVA 2VVVL 2Y7ZB 1HCGB 1KLOA 2WPME 4JYUL 1APQA 1K36A 3FCSB 1IGZA 3N8WA 3LIWB 2P3TA 5CKQA 2P94L 4Y6DB 4RUTA 1G2LB 1EPHA 1IQLL 2WG4B 1G1TA 4G1MB 1N1IA 1BF9A 2H9EC 3SW2A 1EPGA 2EI6B 4COXA 2Y5HL 4PH9A 4MMXB 1UZPA 1DX5I 2YGOA 4ISHL 3R05A 5JB9E 1NT0A 2FLGA 5JB8E 3LAQA 2KB9A 1IQNL 4XBMA 1HZ8A 1OB1C 1FF7A 1CEJA 4Z0KB 2WPJE 2WPHE 4A94C 1I0UA 1KLJL 2YGPA 2Y80B 3BT2A 1EPIA 1MQ5L 4NGAL 1JV2B 2W2QE 3M36L 5KN5C 1YUGA 3ZYJB 2Q1JB 2NPRA 1W7XL 3GISX 2P95L 1MQ6L 1UZQA 3MQEA 2WG3C 2VH6B 1HT5A 2W3IB 2RHPA 5FDQA 3SOBB 2F9BL 2CJIB 1DQBA 3F1SB 3H5CB 2WZPP 1CQEA 2J38B 1L5GB 5JBAE 1JL9A 2VWOL 3BPSE 4X8UL 3U73A 1YO8A 3ZYIB 1W8BL 4BTUA 1Z6EL 2FZZL 1G1QA 1HX2A 1MOXC 4Z0LA 3KL6B 1FSBA 2W26B 3DEMA 1DVAL 5L2YL 1LMMA 2PHBB 2WPIE 3BT1A 1IP0A 3N8VA 2TGFA 3HS6A 2B7DL 1UZKA 3HS7A 2UWLB 1A3PA 1ADXA 1FAKL 1FJSL 1PRHA 2WFXB 5I46L 4ZXYL 2W2PE 1UZJA 3NT1A 3KRKA 1U8CB 4BTTA 5JVZA 2I9AA 3KK6A 4CUDA 1G2MB 3LN0A 1EAIC 3V64C 1ATAA 3N8XA 4D90A 3U7UG 3FBYA 3MDLA 3P5BL 4JYVL 1NFYB 4D0FA 5JVYA 4BDXA 4E1GA 2OYEP 1AUTL 4Y7AB 2WYGB 2DDUA 4Z6AL 1TPGA 3PGHA 5CISA 3N8WB 1B9WA 1LPGA 2K2TA 5L2ZL 2WPLE 2PR3B 4TGFA 1V3XB 4CUFA 3ENSA 3KQDL 2AYLA 5JW1A 4XLWA 2P3FN 2XC0L 2KNIA 3SOQA 3LTGD 1HRFA 4XL1A 3OLTA 1IQIL 1IJQA 2XC4L 1J9CL 1PFXL 1WHEA 4LORA 1CCFA 3HO3A 2J95B 1P0SL 2BOHA 2G00L 2XBVL 4RRYA 1F7EA 1DDXA 4MMYB 1XDTR 4ZXXL 4CSYA 4CUEA 1HREA 1HT8A 5K0HB 1KLIL 1IVOC 3LTFB 1IQJL 1K37A 5CKNA 3ELAL 4LMFA 5COXA 3HS5A 4C16A 1F7MA 3NJPC 4JZDL 1WU1B 4Y71B 2FLBL 3CA7A 3V65B 2VWLL 2W2NE 2Y5GL 1F0RB 2BQ6A 3CS7L 4RS0A 1CX2A 4D0EA 5IKVA 4O02B 3FFGL 3EGFA 4AQTA 1EPJA 1IGXA 1NQLB 1FE2A 2VVCK 4ZHAB 1Q4GA 3NTBA 2VWNL 4YT7L 2Y5FL 2BOKL 3HO5A 2UWOB 4OTYA 2VWMK 1EGFA 3IJEB 2J34B 2XBXL 2EI7B 1IQML 2BOUA 3TGFA 1TLEA 1YUKB 1CCVA 1EMNA 4JZEL 2BQ7A 1IQEL 2P28B 3TK6B 5CKMA 4JZFL 2VH0B 4M10A 3SOVA 3ZYGA 1F0SB 1U67A 1EMOA 2MGPA 1LMJA 1YUFA 1G1RA 3OLUA 3LC3B 3N8YA 3Q3KB 4NA9L 1COUA 4RRZA 1KIGL 3HPTA 1Z6CA 1WHFA 2WPKE 4X8VL 4BDWA 2K2SB 4O1ZA 4BTIA 1DIYA 4X8TL 1C5MF 2UWPB 2FLRL 2XBYL 3IITB 4BXWA 4Y7BB 4MMZB 2GD4A 2ADXA 3QH0A 2BO2A 2P3FL 1IQHL 4X8SL 1IQKL 2P93L 5EGMB 1HAFA 3ASIA 4ISIL 2Y7XB 4M11A 5IKQA 5L30L 4ZAEB 1IQFL 1LPZA 2WFTA 4A7IA 5E8DA 1EQHA 5F1AA 4BXSA 1NFWB 2RA0L 3N8ZA 1IOEL 1IOXA 2J4IB 3GCXE 2Y81B 1FFMA 2P3UA 1EQGA 5KIRA 1HAEA 3LC5B 1QFKL 1ATDA 4RRWA 5IKRA 3K9XA 1XKAL 3CFWA 5IKTA 2MHPA 3POYA 1XFEA 2OYUP 2XC5L 4ZH8B 2PUQL 3TK5B 2H9EL 2Y82B 1APOA 1NPEB 2W3KB 3KQCL 4YZUB 3NTGA 1SZBA 3GCWE 1O5DL 1G1SA 5JBCE 1HJ7A 1EZQB 1X7AL 2BZ6L 1NFXB 3LN1A 3TBDA 1FAXL 1CVWL 4NG9L 2Y38A 1ATBA 4YT6L 1P9JA 1JBUL 2VVUL 3KQEL 2BQWA 2EI8B 3C9AC 3TZIA 2J2UB 2FD6A 5JBBE 2RNLA 1LQDA 6COXA 3M37L 2BMGA 2J94B 1CVUA 1LPKA 1KSNB 2VJ3A 2MGRA 2YGQA 2D1JB 3KQBL 1NFUB 4FM5A 4RRXA 5F19A 3QMOA 2I9BA 1GK5A 2M74A 2W2ME 2KL7A 3HO4A 1N7DA 1M1XB 1XKBA 3CENL 3TH3L 2KV4A 4Y79B 1TOZA 1RFNB 2BOXA 1L3YA 4Y76B 1NZIA 3KCGL 2WYJB 3QCWA 1ZAQA 1URKA 3S6XA 3RR3A 2W86A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1PGE A;  1IQG L;  3F6U L;  2XBW L;  1PTH A;  2P26 A;  3N8Y B;  2P16 L;  2W2O E;  1ATE A;  1PXX A;  4OTJ A;  1YGC L;  2JKH L;  3Q7D A;  1EBV A;  2VVV L;  2Y7Z B;  1HCG B;  1KLO A;  2WPM E;  4JYU L;  1APQ A;  1K36 A;  3FCS B;  1IGZ A;  3N8W A;  3LIW B;  2P3T A;  5CKQ A;  2P94 L;  4Y6D B;  4RUT A;  1G2L B;  1EPH A;  1IQL L;  2WG4 B;  1G1T A;  4G1M B;  1N1I A;  1BF9 A;  3SW2 A;  1EPG A;  2EI6 B;  4COX A;  2Y5H L;  4PH9 A;  4MMX B;  1UZP A;  1DX5 I;  2YGO A;  4ISH L;  3R05 A;  5JB9 E;  1NT0 A;  2FLG A;  5JB8 E;  3LAQ A;  2KB9 A;  1IQN L;  4XBM A;  1HZ8 A;  1OB1 C;  1FF7 A;  1CEJ A;  4Z0K B;  2WPJ E;  2WPH E;  1I0U A;  1KLJ L;  2YGP A;  2Y80 B;  3BT2 A;  1EPI A;  1MQ5 L;  4NGA L;  1JV2 B;  2W2Q E;  3M36 L;  5KN5 C;  1YUG A;  3ZYJ B;  2Q1J B;  2NPR A;  1W7X L;  3GIS X;  2P95 L;  1MQ6 L;  1UZQ A;  3MQE A;  2WG3 C;  2VH6 B;  1HT5 A;  2W3I B;  2RHP A;  5FDQ A;  3SOB B;  2F9B L;  2CJI B;  1DQB A;  3F1S B;  3H5C B;  1CQE A;  2J38 B;  1L5G B;  5JBA E;  1JL9 A;  2VWO L;  3BPS E;  4X8U L;  3U73 A;  1YO8 A;  3ZYI B;  1W8B L;  4BTU A;  1Z6E L;  2FZZ L;  1G1Q A;  1HX2 A;  1MOX C;  4Z0L A;  3KL6 B;  1FSB A;  2W26 B;  3DEM A;  1DVA L;  5L2Y L;  2PHB B;  2WPI E;  3BT1 A;  1IP0 A;  3N8V A;  2TGF A;  3HS6 A;  2B7D L;  1UZK A;  3HS7 A;  2UWL B;  1A3P A;  1ADX A;  1FAK L;  1FJS L;  1PRH A;  2WFX B;  5I46 L;  4ZXY L;  2W2P E;  1UZJ A;  3NT1 A;  3KRK A;  1U8C B;  4BTT A;  5JVZ A;  2I9A A;  3KK6 A;  4CUD A;  1G2M B;  3LN0 A;  1EAI C;  3V64 C;  1ATA A;  3N8X A;  4D90 A;  3U7U G;  3FBY A;  3MDL A;  3P5B L;  4JYV L;  1NFY B;  4D0F A;  5JVY A;  4BDX A;  4E1G A;  2OYE P;  1AUT L;  4Y7A B;  2WYG B;  2DDU A;  4Z6A L;  1TPG A;  3PGH A;  5CIS A;  3N8W B;  1B9W A;  1LPG A;  2K2T A;  5L2Z L;  2WPL E;  2PR3 B;  4TGF A;  1V3X B;  4CUF A;  3ENS A;  3KQD L;  2AYL A;  5JW1 A;  4XLW A;  2P3F N;  2XC0 L;  3SOQ A;  3LTG D;  1HRF A;  4XL1 A;  3OLT A;  1IQI L;  1IJQ A;  2XC4 L;  1J9C L;  1PFX L;  1WHE A;  4LOR A;  1CCF A;  3HO3 A;  2J95 B;  1P0S L;  2BOH A;  2G00 L;  2XBV L;  4RRY A;  1F7E A;  1DDX A;  4MMY B;  1XDT R;  4ZXX L;  4CSY A;  4CUE A;  1HRE A;  1HT8 A;  5K0H B;  1KLI L;  1IVO C;  3LTF B;  1IQJ L;  1K37 A;  5CKN A;  3ELA L;  4LMF A;  5COX A;  3HS5 A;  4C16 A;  1F7M A;  3NJP C;  4JZD L;  1WU1 B;  4Y71 B;  2FLB L;  3CA7 A;  3V65 B;  2VWL L;  2W2N E;  2Y5G L;  1F0R B;  2BQ6 A;  3CS7 L;  4RS0 A;  1CX2 A;  4D0E A;  5IKV A;  4O02 B;  3FFG L;  3EGF A;  4AQT A;  1EPJ A;  1IGX A;  1NQL B;  1FE2 A;  2VVC K;  4ZHA B;  1Q4G A;  3NTB A;  2VWN L;  4YT7 L;  2Y5F L;  2BOK L;  3HO5 A;  2UWO B;  4OTY A;  2VWM K;  1EGF A;  3IJE B;  2J34 B;  2XBX L;  2EI7 B;  1IQM L;  2BOU A;  3TGF A;  1TLE A;  1YUK B;  1CCV A;  1EMN A;  4JZE L;  2BQ7 A;  1IQE L;  2P28 B;  3TK6 B;  5CKM A;  4JZF L;  2VH0 B;  4M10 A;  3SOV A;  3ZYG A;  1F0S B;  1U67 A;  1EMO A;  2MGP A;  1LMJ A;  1YUF A;  1G1R A;  3OLU A;  3LC3 B;  3N8Y A;  3Q3K B;  4NA9 L;  1COU A;  4RRZ A;  1KIG L;  3HPT A;  1Z6C A;  1WHF A;  2WPK E;  4X8V L;  4BDW A;  2K2S B;  4O1Z A;  4BTI A;  1DIY A;  4X8T L;  1C5M F;  2UWP B;  2FLR L;  2XBY L;  3IIT B;  4BXW A;  4Y7B B;  4MMZ B;  2GD4 A;  2ADX A;  3QH0 A;  2BO2 A;  2P3F L;  1IQH L;  4X8S L;  1IQK L;  2P93 L;  5EGM B;  1HAF A;  3ASI A;  4ISI L;  2Y7X B;  4M11 A;  5IKQ A;  5L30 L;  4ZAE B;  1IQF L;  1LPZ A;  2WFT A;  4A7I A;  5E8D A;  1EQH A;  5F1A A;  4BXS A;  1NFW B;  2RA0 L;  3N8Z A;  1IOE L;  1IOX A;  2J4I B;  3GCX E;  2Y81 B;  1FFM A;  2P3U A;  1EQG A;  5KIR A;  1HAE A;  3LC5 B;  1QFK L;  1ATD A;  4RRW A;  5IKR A;  3K9X A;  1XKA L;  3CFW A;  5IKT A;  2MHP A;  3POY A;  1XFE A;  2OYU P;  2XC5 L;  4ZH8 B;  2PUQ L;  3TK5 B;  2H9E L;  2Y82 B;  1APO A;  1NPE B;  2W3K B;  3KQC L;  4YZU B;  3NTG A;  1SZB A;  3GCW E;  1O5D L;  1G1S A;  5JBC E;  1HJ7 A;  1EZQ B;  1X7A L;  2BZ6 L;  1NFX B;  3LN1 A;  3TBD A;  1FAX L;  1CVW L;  4NG9 L;  2Y38 A;  1ATB A;  4YT6 L;  1P9J A;  1JBU L;  2VVU L;  3KQE L;  2BQW A;  2EI8 B;  3C9A C;  3TZI A;  2J2U B;  2FD6 A;  5JBB E;  2RNL A;  1LQD A;  6COX A;  3M37 L;  2BMG A;  2J94 B;  1CVU A;  1LPK A;  1KSN B;  2VJ3 A;  2MGR A;  2D1J B;  3KQB L;  1NFU B;  4FM5 A;  4RRX A;  5F19 A;  3QMO A;  2I9B A;  1GK5 A;  2M74 A;  2W2M E;  2KL7 A;  3HO4 A;  1N7D A;  1M1X B;  1XKB A;  3CEN L;  3TH3 L;  2KV4 A;  4Y79 B;  1TOZ A;  1RFN B;  2BOX A;  1L3Y A;  4Y76 B;  1NZI A;  3KCG L;  2WYJ B;  3QCW A;  1ZAQ A;  1URK A;  3RR3 A;  2W86 A; 
#chains in the Genus database with same CATH topology
 1PGE A;  1IQG L;  2BT8 A;  3F6U L;  2XBW L;  1PTH A;  2P26 A;  3N8Y B;  2P16 L;  2W2O E;  1ATE A;  1PXX A;  4OTJ A;  1YGC L;  2JKH L;  3Q7D A;  1EBV A;  2VVV L;  2Y7Z B;  1HCG B;  1KLO A;  2WPM E;  4JYU L;  1APQ A;  1K36 A;  3FCS B;  1IGZ A;  3N8W A;  3LIW B;  2P3T A;  5CKQ A;  2P94 L;  4Y6D B;  4RUT A;  1G2L B;  1EPH A;  1IQL L;  2WG4 B;  1G1T A;  4G1M B;  1N1I A;  1BF9 A;  2H9E C;  3SW2 A;  1EPG A;  2EI6 B;  4COX A;  2Y5H L;  4PH9 A;  4MMX B;  1UZP A;  1DX5 I;  2YGO A;  4ISH L;  3R05 A;  5JB9 E;  1NT0 A;  2FLG A;  5JB8 E;  3LAQ A;  2KB9 A;  1IQN L;  4XBM A;  1HZ8 A;  1OB1 C;  1FF7 A;  1CEJ A;  4Z0K B;  2WPJ E;  2WPH E;  4A94 C;  1I0U A;  1KLJ L;  2YGP A;  2Y80 B;  3BT2 A;  1V1I A;  1EPI A;  1MQ5 L;  4NGA L;  1JV2 B;  2W2Q E;  3M36 L;  5KN5 C;  1YUG A;  3ZYJ B;  2Q1J B;  2NPR A;  1W7X L;  3GIS X;  2P95 L;  1MQ6 L;  1UZQ A;  3MQE A;  2WG3 C;  1QIU A;  2VH6 B;  1HT5 A;  2W3I B;  2RHP A;  5FDQ A;  1V1H A;  3SOB B;  2F9B L;  2CJI B;  1DQB A;  3F1S B;  3H5C B;  2WZP P;  1CQE A;  2J38 B;  1L5G B;  5JBA E;  1JL9 A;  2VWO L;  3BPS E;  4X8U L;  3U73 A;  1YO8 A;  3ZYI B;  1W8B L;  4BTU A;  1Z6E L;  2FZZ L;  1G1Q A;  1HX2 A;  1MOX C;  4Z0L A;  3KL6 B;  1FSB A;  2W26 B;  3DEM A;  1DVA L;  5L2Y L;  1LMM A;  2PHB B;  2WPI E;  3BT1 A;  1IP0 A;  3N8V A;  2TGF A;  3HS6 A;  2B7D L;  1UZK A;  3HS7 A;  2UWL B;  1A3P A;  1ADX A;  1FAK L;  1FJS L;  1PRH A;  2WFX B;  5I46 L;  2BT7 A;  2W2P E;  4ZXY L;  1UZJ A;  3NT1 A;  3KRK A;  1U8C B;  4BTT A;  5JVZ A;  2BSF A;  2I9A A;  3KK6 A;  4CUD A;  1G2M B;  3LN0 A;  1EAI C;  3V64 C;  1ATA A;  3N8X A;  4D90 A;  3U7U G;  3FBY A;  3MDL A;  3P5B L;  4JYV L;  1NFY B;  4D0F A;  5JVY A;  4BDX A;  4E1G A;  2OYE P;  1AUT L;  4Y7A B;  2WYG B;  2DDU A;  4Z6A L;  1LK9 A;  1TPG A;  3PGH A;  5CIS A;  1B9W A;  1LPG A;  2K2T A;  3N8W B;  5L2Z L;  2WPL E;  2PR3 B;  4TGF A;  1V3X B;  4CUF A;  3ENS A;  3KQD L;  2JJL A;  2AYL A;  5JW1 A;  4XLW A;  2P3F N;  2XC0 L;  2KNI A;  3SOQ A;  3LTG D;  1HRF A;  4XL1 A;  3OLT A;  1IQI L;  1IJQ A;  2XC4 L;  1J9C L;  1PFX L;  1WHE A;  4LOR A;  1CCF A;  3HO3 A;  2J95 B;  1P0S L;  2BOH A;  2G00 L;  2XBV L;  4RRY A;  1F7E A;  1DDX A;  4MMY B;  1XDT R;  4ZXX L;  4CSY A;  4CUE A;  1HRE A;  1HT8 A;  5K0H B;  1KLI L;  1IVO C;  3LTF B;  1IQJ L;  1K37 A;  5CKN A;  3ELA L;  4LMF A;  5COX A;  3HS5 A;  4C16 A;  1F7M A;  3NJP C;  4JZD L;  1WU1 B;  4Y71 B;  2FLB L;  3CA7 A;  3V65 B;  2VWL L;  2W2N E;  2Y5G L;  1F0R B;  2BQ6 A;  3CS7 L;  4RS0 A;  1CX2 A;  4D0E A;  5IKV A;  4O02 B;  3FFG L;  3EGF A;  4AQT A;  1EPJ A;  1IGX A;  1NQL B;  1FE2 A;  2VVC K;  4ZHA B;  1Q4G A;  3NTB A;  2VWN L;  4YT7 L;  2Y5F L;  2BOK L;  1KKE A;  3HO5 A;  2UWO B;  4OTY A;  2VWM K;  1EGF A;  3IJE B;  2J34 B;  2XBX L;  2EI7 B;  1IQM L;  2BOU A;  3TGF A;  1TLE A;  2HOR A;  1YUK B;  1CCV A;  1EMN A;  4JZE L;  2BQ7 A;  1IQE L;  2P28 B;  3TK6 B;  5CKM A;  4JZF L;  2VH0 B;  4GU4 A;  4M10 A;  3SOV A;  3ZYG A;  1F0S B;  1U67 A;  1EMO A;  2MGP A;  1LMJ A;  1YUF A;  1G1R A;  3OLU A;  3LC3 B;  3N8Y A;  3Q3K B;  4NA9 L;  1COU A;  4RRZ A;  1KIG L;  3HPT A;  1Z6C A;  1WHF A;  2WPK E;  4X8V L;  4BDW A;  2K2S B;  4O1Z A;  4BTI A;  1DIY A;  4X8T L;  1C5M F;  2UWP B;  2FLR L;  2VRS A;  2XBY L;  3IIT B;  4BXW A;  4Y7B B;  4MMZ B;  2GD4 A;  2ADX A;  2HOX A;  3QH0 A;  2BO2 A;  2P3F L;  1IQH L;  4X8S L;  1IQK L;  2P93 L;  5EGM B;  1HAF A;  3ASI A;  4ISI L;  2Y7X B;  4M11 A;  5IKQ A;  5L30 L;  4ZAE B;  1IQF L;  1LPZ A;  2WFT A;  4A7I A;  5E8D A;  1EQH A;  5F1A A;  4BXS A;  1NFW B;  2RA0 L;  3N8Z A;  1IOE L;  1IOX A;  2J4I B;  3GCX E;  2Y81 B;  1FFM A;  2P3U A;  1EQG A;  5KIR A;  1HAE A;  3LC5 B;  1QFK L;  1ATD A;  4RRW A;  5IKR A;  3K9X A;  1XKA L;  3CFW A;  5IKT A;  2MHP A;  3POY A;  1XFE A;  2OYU P;  2XC5 L;  4ZH8 B;  2PUQ L;  3TK5 B;  2H9E L;  2Y82 B;  1APO A;  1NPE B;  2W3K B;  3KQC L;  4YZU B;  3NTG A;  1SZB A;  3GCW E;  1O5D L;  1G1S A;  5JBC E;  1HJ7 A;  1EZQ B;  1X7A L;  2BZ6 L;  1NFX B;  3LN1 A;  3TBD A;  1FAX L;  1CVW L;  4NG9 L;  2Y38 A;  1ATB A;  4YT6 L;  1P9J A;  1JBU L;  2VVU L;  3KQE L;  2BQW A;  2EI8 B;  3C9A C;  3TZI A;  2J2U B;  2FD6 A;  4GU3 A;  5JBB E;  2RNL A;  1LQD A;  6COX A;  3M37 L;  2BMG A;  2J94 B;  1CVU A;  1LPK A;  1KSN B;  2VJ3 A;  2MGR A;  2YGQ A;  2D1J B;  3KQB L;  1NFU B;  4FM5 A;  4RRX A;  5F19 A;  3QMO A;  2I9B A;  1GK5 A;  2M74 A;  2W2M E;  2KL7 A;  3HO4 A;  1N7D A;  1M1X B;  1XKB A;  3CEN L;  3TH3 L;  2KV4 A;  4Y79 B;  1TOZ A;  1RFN B;  2BOX A;  1L3Y A;  4Y76 B;  1NZI A;  3KCG L;  2WYJ B;  3QCW A;  1ZAQ A;  1URK A;  3S6X A;  3RR3 A;  2W86 A; 
#chains in the Genus database with same CATH homology
 1PGE A;  1IQG L;  3F6U L;  2XBW L;  1PTH A;  2P26 A;  3N8Y B;  2P16 L;  2W2O E;  1ATE A;  1PXX A;  4OTJ A;  1YGC L;  2JKH L;  3Q7D A;  1EBV A;  2VVV L;  2Y7Z B;  1HCG B;  1KLO A;  2WPM E;  4JYU L;  1APQ A;  1K36 A;  3FCS B;  1IGZ A;  3N8W A;  3LIW B;  2P3T A;  5CKQ A;  2P94 L;  4Y6D B;  4RUT A;  1G2L B;  1EPH A;  1IQL L;  2WG4 B;  1G1T A;  4G1M B;  1N1I A;  1BF9 A;  2H9E C;  3SW2 A;  1EPG A;  2EI6 B;  4COX A;  2Y5H L;  4PH9 A;  4MMX B;  1UZP A;  1DX5 I;  2YGO A;  4ISH L;  3R05 A;  5JB9 E;  1NT0 A;  2FLG A;  5JB8 E;  3LAQ A;  2KB9 A;  1IQN L;  4XBM A;  1HZ8 A;  1OB1 C;  1FF7 A;  1CEJ A;  4Z0K B;  2WPJ E;  2WPH E;  4A94 C;  1I0U A;  1KLJ L;  2YGP A;  2Y80 B;  3BT2 A;  1EPI A;  1MQ5 L;  4NGA L;  1JV2 B;  2W2Q E;  3M36 L;  5KN5 C;  1YUG A;  3ZYJ B;  2Q1J B;  2NPR A;  1W7X L;  3GIS X;  2P95 L;  1MQ6 L;  1UZQ A;  3MQE A;  2WG3 C;  2VH6 B;  1HT5 A;  2W3I B;  2RHP A;  5FDQ A;  3SOB B;  2F9B L;  2CJI B;  1DQB A;  3F1S B;  3H5C B;  2WZP P;  1CQE A;  2J38 B;  1L5G B;  5JBA E;  1JL9 A;  2VWO L;  3BPS E;  4X8U L;  3U73 A;  1YO8 A;  3ZYI B;  1W8B L;  4BTU A;  1Z6E L;  2FZZ L;  1G1Q A;  1HX2 A;  1MOX C;  4Z0L A;  3KL6 B;  1FSB A;  2W26 B;  3DEM A;  1DVA L;  5L2Y L;  1LMM A;  2PHB B;  2WPI E;  3BT1 A;  1IP0 A;  3N8V A;  2TGF A;  3HS6 A;  2B7D L;  1UZK A;  3HS7 A;  2UWL B;  1A3P A;  1ADX A;  1FAK L;  1FJS L;  1PRH A;  2WFX B;  5I46 L;  4ZXY L;  2W2P E;  1UZJ A;  3NT1 A;  3KRK A;  1U8C B;  4BTT A;  5JVZ A;  2I9A A;  3KK6 A;  4CUD A;  1G2M B;  3LN0 A;  1EAI C;  3V64 C;  1ATA A;  3N8X A;  4D90 A;  3U7U G;  3FBY A;  3MDL A;  3P5B L;  4JYV L;  1NFY B;  4D0F A;  5JVY A;  4BDX A;  4E1G A;  2OYE P;  1AUT L;  4Y7A B;  2WYG B;  2DDU A;  4Z6A L;  1TPG A;  3PGH A;  5CIS A;  3N8W B;  1B9W A;  1LPG A;  2K2T A;  5L2Z L;  2WPL E;  2PR3 B;  4TGF A;  1V3X B;  4CUF A;  3ENS A;  3KQD L;  2AYL A;  5JW1 A;  4XLW A;  2P3F N;  2XC0 L;  2KNI A;  3SOQ A;  3LTG D;  1HRF A;  4XL1 A;  3OLT A;  1IQI L;  1IJQ A;  2XC4 L;  1J9C L;  1PFX L;  1WHE A;  4LOR A;  1CCF A;  3HO3 A;  2J95 B;  1P0S L;  2BOH A;  2G00 L;  2XBV L;  4RRY A;  1F7E A;  1DDX A;  4MMY B;  1XDT R;  4ZXX L;  4CSY A;  4CUE A;  1HRE A;  1HT8 A;  5K0H B;  1KLI L;  1IVO C;  3LTF B;  1IQJ L;  1K37 A;  5CKN A;  3ELA L;  4LMF A;  5COX A;  3HS5 A;  4C16 A;  1F7M A;  3NJP C;  4JZD L;  1WU1 B;  4Y71 B;  2FLB L;  3CA7 A;  3V65 B;  2VWL L;  2W2N E;  2Y5G L;  1F0R B;  2BQ6 A;  3CS7 L;  4RS0 A;  1CX2 A;  4D0E A;  5IKV A;  4O02 B;  3FFG L;  3EGF A;  4AQT A;  1EPJ A;  1IGX A;  1NQL B;  1FE2 A;  2VVC K;  4ZHA B;  1Q4G A;  3NTB A;  2VWN L;  4YT7 L;  2Y5F L;  2BOK L;  3HO5 A;  2UWO B;  4OTY A;  2VWM K;  1EGF A;  3IJE B;  2J34 B;  2XBX L;  2EI7 B;  1IQM L;  2BOU A;  3TGF A;  1TLE A;  1YUK B;  1CCV A;  1EMN A;  4JZE L;  2BQ7 A;  1IQE L;  2P28 B;  3TK6 B;  5CKM A;  4JZF L;  2VH0 B;  4M10 A;  3SOV A;  3ZYG A;  1F0S B;  1U67 A;  1EMO A;  2MGP A;  1LMJ A;  1YUF A;  1G1R A;  3OLU A;  3LC3 B;  3N8Y A;  3Q3K B;  4NA9 L;  1COU A;  4RRZ A;  1KIG L;  3HPT A;  1Z6C A;  1WHF A;  2WPK E;  4X8V L;  4BDW A;  2K2S B;  4O1Z A;  4BTI A;  1DIY A;  4X8T L;  1C5M F;  2UWP B;  2FLR L;  2XBY L;  3IIT B;  4BXW A;  4Y7B B;  4MMZ B;  2GD4 A;  2ADX A;  3QH0 A;  2BO2 A;  2P3F L;  1IQH L;  4X8S L;  1IQK L;  2P93 L;  5EGM B;  1HAF A;  3ASI A;  4ISI L;  2Y7X B;  4M11 A;  5IKQ A;  5L30 L;  4ZAE B;  1IQF L;  1LPZ A;  2WFT A;  4A7I A;  5E8D A;  1EQH A;  5F1A A;  4BXS A;  1NFW B;  2RA0 L;  3N8Z A;  1IOE L;  1IOX A;  2J4I B;  3GCX E;  2Y81 B;  1FFM A;  2P3U A;  1EQG A;  5KIR A;  1HAE A;  3LC5 B;  1QFK L;  1ATD A;  4RRW A;  5IKR A;  3K9X A;  1XKA L;  3CFW A;  5IKT A;  2MHP A;  3POY A;  1XFE A;  2OYU P;  2XC5 L;  4ZH8 B;  2PUQ L;  3TK5 B;  2H9E L;  2Y82 B;  1APO A;  1NPE B;  2W3K B;  3KQC L;  4YZU B;  3NTG A;  1SZB A;  3GCW E;  1O5D L;  1G1S A;  5JBC E;  1HJ7 A;  1EZQ B;  1X7A L;  2BZ6 L;  1NFX B;  3LN1 A;  3TBD A;  1FAX L;  1CVW L;  4NG9 L;  2Y38 A;  1ATB A;  4YT6 L;  1P9J A;  1JBU L;  2VVU L;  3KQE L;  2BQW A;  2EI8 B;  3C9A C;  3TZI A;  2J2U B;  2FD6 A;  5JBB E;  2RNL A;  1LQD A;  6COX A;  3M37 L;  2BMG A;  2J94 B;  1CVU A;  1LPK A;  1KSN B;  2VJ3 A;  2MGR A;  2YGQ A;  2D1J B;  3KQB L;  1NFU B;  4FM5 A;  4RRX A;  5F19 A;  3QMO A;  2I9B A;  1GK5 A;  2M74 A;  2W2M E;  2KL7 A;  3HO4 A;  1N7D A;  1M1X B;  1XKB A;  3CEN L;  3TH3 L;  2KV4 A;  4Y79 B;  1TOZ A;  1RFN B;  2BOX A;  1L3Y A;  4Y76 B;  1NZI A;  3KCG L;  2WYJ B;  3QCW A;  1ZAQ A;  1URK A;  3S6X A;  3RR3 A;  2W86 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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