2XBWL

Factor xa in complex with a pyrrolidine-3,4-dicarboxylic acid inhibitor
Total Genus 10
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
10
sequence length
50
structure length
50
Chain Sequence
CSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLE
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Discovery of a Factor Xa Inhibitor (3R,4R)-1-(2,2-Difluoro-Ethyl)-Pyrrolidine-3,4-Dicarboxylic Acid 3-[(5-Chloro-Pyridin-2-Yl)-Amide] 4-{[2-Fluoro-4-(2-Oxo-2H-Pyridin-1-Yl)-Phenyl]-Amide} as a Clinical Candidate.
pubmed doi rcsb
molecule tags Blood clotting
source organism Homo sapiens
molecule keywords ACTIVATED FACTOR XA HEAVY CHAIN
total genus 10
structure length 50
sequence length 50
ec nomenclature ec 3.4.21.6: Coagulation factor Xa.
pdb deposition date 2010-04-15

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
L PF14670 FXa_inhibition Coagulation Factor Xa inhibitory site
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.25.10 Mainly Beta Ribbon Laminin Laminin 2xbwL00
4NA9L 1HRFA 1P0SL 3KCGL 1RFNB 4JYUL 3MDLA 1LPZA 2FLBL 4ISIL 4AQTA 2PHBB 2P94L 1DIYA 2UWLB 3PGHA 1KLIL 5JBBE 4BXWA 3N8YB 3LAQA 1HX2A 5JVYA 3OLUA 5IKQA 2W3KB 2VJ3A 3POYA 1UZJA 1CVUA 1Z6CA 2MGRA 2D1JB 5IKRA 4BDWA 5KIRA 2K2SB 1G2LB 5CISA 4M11A 3GCXE 1HT8A 1TLEA 3M36L 1FFMA 4X8TL 2FLGA 2Y38A 2G00L 2J94B 3TK6B 1HREA 3C9AC 3RR3A 1IQNL 1LMJA 3ELAL 2VWMK 3F6UL 3BPSE 1ATAA 5F19A 4E1GA 4Z0LA 2VVVL 1G1SA 4ZXXL 2P16L 4ZH8B 3ASIA 4RS0A 3N8XA 2P3TA 1FF7A 2KL7A 3TBDA 2XBXL 5JB9E 1G2MB 3TGFA 1DX5I 3V65B 1HJ7A 1IQGL 2P3UA 1EPIA 1HCGB 3LC3B 3EGFA 2Y80B 3LC5B 1QFKL 4Y76B 5JBCE 1HZ8A 4D0FA 1P9JA 1IQHL 2P3FL 1WHFA 4A7IA 4G1MB 2VWLL 2XC5L 2W2ME 1IGZA 2WFTA 5L2ZL 4XLWA 1YUGA 1EPGA 2VH6B 1CQEA 3KK6A 1IQIL 3FFGL 4LORA 4O02B 2AYLA 5I46L 3TH3L 1N1IA 1YUFA 1GK5A 3N8WB 2BMGA 2P28B 4COXA 1CVWL 1FJSL 3Q3KB 5COXA 1IQML 5IKTA 4JZEL 1L5GB 5JB8E 3N8ZA 1KSNB 1MQ5L 4CSYA 1IGXA 1Q4GA 4ZXYL 2YGOA 2VVCK 2W2PE 3LTGD 3N8WA 2I9AA 1NT0A 1ZAQA 2I9BA 3ZYIB 4OTJA 3CENL 4CUFA 1LPKA 2W2QE 1U8CB 1OB1C 1EQHA 4Y7AB 2BO2A 1Z6EL 2EI7B 1APOA 2Y5FL 2W26B 3N8VA 1FSBA 1NFUB 5CKNA 1W7XL 2WFXB 5JBAE 1LQDA 4NG9L 1KLOA 2UWOB 4XL1A 2BQWA 1YUKB 1UZQA 4Y7BB 3SOQA 1XFEA 2XBYL 4Y71B 1HAEA 5JW1A 2NPRA 2Y81B 4RRWA 1NPEB 4D90A 3LN1A 2J95B 3CA7A 1UZPA 1K36A 2RHPA 3KL6B 1N7DA 3QH0A 2MGPA 1IQJL 2P93L 2W2NE 3HS5A 2DDUA 1EMNA 2UWPB 1V3XB 2J38B 3R05A 1IOXA 4PH9A 3ZYJB 1L3YA 4OTYA 3V64C 1MQ6L 1DVAL 1M1XB 1PXXA 2VVUL 3KRKA 6COXA 2F9BL 1CCVA 4Y6DB 2EI6B 4JZFL 2XBWL 4Z0KB 1XKAL 4CUDA 2BOUA 4C16A 4X8SL 1F0RB 3FBYA 3FCSB 3HS6A 3KQBL 2WPKE 3NJPC 4X8VL 2VWOL 3KQCL 1YO8A 4XBMA 3HO4A 4TGFA 4X8UL 5K0HB 2J34B 2JKHL 5IKVA 1JL9A 1NFWB 1JV2B 1EPJA 1PGEA 1UZKA 1G1RA 1EBVA 3GCWE 3P5BL 2W86A 2YGPA 2XC4L 1YGCL 4RUTA 2W3IB 1ATDA 4CUEA 1EMOA 2J4IB 3ZYGA 2KV4A 2Q1JB 4ZHAB 1APQA 3HPTA 1XKBA 1JBUL 1F7EA 1URKA 1COUA 1AUTL 1KIGL 3GISX 4YT6L 3TK5B 2W2OE 1ADXA 2RNLA 3KQEL 1CX2A 1O5DL 4FM5A 1EAIC 2FLRL 3NTBA 5E8DA 4O1ZA 4BXSA 3F1SB 3CFWA 1NFYB 1G1QA 3TZIA 4ISHL 2WPHE 2WYGB 2OYEP 2OYUP 4LMFA 1X7AL 1BF9A 1HAFA 2P26A 2WPLE 4BTTA 3HO3A 4Z6AL 3IITB 1IQLL 3QMOA 1I0UA 2K2TA 3ENSA 2H9EL 4BTIA 2VH0B 1EZQB 4MMXB 2FD6A 1PRHA 1FAXL 2BOXA 2PR3B 2B7DL 5L30L 1G1TA 4JYVL 4MMZB 1EGFA 5CKMA 2XC0L 3QCWA 3LIWB 4Y79B 5EGMB 3N8YA 5CKQA 4D0EA 3M37L 4JZDL 3DEMA 1MOXC 2BQ6A 1XDTR 2TGFA 1U67A 4RRYA 2P95L 2Y5HL 5JVZA 2GD4A 2WYJB 1DQBA 2ADXA 4YZUB 3HS7A 3U7UG 1WHEA 4NGAL 5F1AA 5L2YL 4M10A 4RRXA 2FZZL 3LTFB 1PFXL 2M74A 1CCFA 2P3FN 2KB9A 1CEJA 1IJQA 3OLTA 1KLJL 1IQFL 1B9WA 1J9CL 2WPIE 4BDXA 2EI8B 3SOBB 1FAKL 2WG3C 3NTGA 1IOEL 1TPGA 1IQEL 4MMYB 3LN0A 1EQGA 3NT1A 1FE2A 3H5CB 2BOHA 1ATBA 1LPGA 1PTHA 2BQ7A 2Y7XB 1A3PA 2PUQL 3SW2A 1IVOC 1F0SB 4YT7L 1W8BL 1NQLB 1SZBA 4RRZA 1DDXA 3U73A 5KN5C 2WPJE 2WG4B 2VWNL 1TOZA 2XBVL 3Q7DA 2CJIB 2Y82B 1F7MA 4ZAEB 3SOVA 2BOKL 1IQKL 2MHPA 5FDQA 3BT2A 3CS7L 1K37A 1C5MF 2Y7ZB 1HT5A 3BT1A 3HO5A 2RA0L 4BTUA 1IP0A 1NZIA 1WU1B 3MQEA 1EPHA 2J2UB 1ATEA 2Y5GL 1NFXB 3IJEB 3KQDL 2BZ6L 3K9XA 2WPME
chains in the Genus database with same CATH superfamily
4NA9L 1HRFA 1P0SL 3KCGL 1RFNB 4JYUL 3MDLA 1LPZA 2FLBL 4ISIL 4AQTA 2PHBB 2P94L 1DIYA 2H9EC 2UWLB 3PGHA 1KLIL 5JBBE 4BXWA 3N8YB 3LAQA 1HX2A 5JVYA 3OLUA 2WZPP 5IKQA 2W3KB 1V1IA 2VJ3A 3POYA 1UZJA 1CVUA 1Z6CA 2MGRA 2D1JB 5IKRA 4BDWA 5KIRA 2K2SB 1G2LB 5CISA 4M11A 3GCXE 2BSFA 1HT8A 1TLEA 3M36L 1FFMA 4X8TL 2FLGA 4GU4A 2Y38A 2G00L 2J94B 3TK6B 1HREA 3C9AC 3RR3A 1IQNL 1LMJA 3ELAL 2VWMK 3F6UL 1LK9A 3BPSE 1ATAA 5F19A 4E1GA 4Z0LA 2VVVL 1G1SA 4ZXXL 2P16L 4ZH8B 3ASIA 4RS0A 3N8XA 2P3TA 1FF7A 2KL7A 3TBDA 2XBXL 5JB9E 1G2MB 3TGFA 1DX5I 3V65B 1HJ7A 1IQGL 2P3UA 1EPIA 1HCGB 3LC3B 3EGFA 2Y80B 3LC5B 1QFKL 4Y76B 5JBCE 1HZ8A 4D0FA 1P9JA 1IQHL 2P3FL 1WHFA 4A7IA 4G1MB 2HORA 2VWLL 2XC5L 2W2ME 1IGZA 2WFTA 5L2ZL 4XLWA 1YUGA 1EPGA 2VH6B 1CQEA 3KK6A 1IQIL 3FFGL 4LORA 4O02B 2AYLA 5I46L 3TH3L 1N1IA 1YUFA 1GK5A 3N8WB 2BMGA 2P28B 4COXA 1CVWL 1FJSL 3Q3KB 5COXA 1IQML 5IKTA 4JZEL 1L5GB 5JB8E 3N8ZA 1KSNB 1MQ5L 4CSYA 1IGXA 1Q4GA 2BT8A 4ZXYL 2YGOA 2VVCK 2W2PE 3LTGD 3N8WA 2I9AA 1NT0A 1ZAQA 2I9BA 3ZYIB 4OTJA 3CENL 4CUFA 1LPKA 2W2QE 1U8CB 1OB1C 1QIUA 1EQHA 4Y7AB 2BO2A 1Z6EL 2EI7B 1APOA 2Y5FL 2W26B 3N8VA 1FSBA 1NFUB 5CKNA 1W7XL 2WFXB 5JBAE 1LQDA 4NG9L 1KLOA 2UWOB 4XL1A 2BQWA 1YUKB 1UZQA 4Y7BB 3SOQA 1XFEA 2XBYL 4Y71B 1HAEA 5JW1A 2NPRA 2Y81B 4RRWA 1NPEB 4D90A 3LN1A 2J95B 3CA7A 1UZPA 1K36A 3KL6B 1KKEA 2RHPA 1N7DA 3QH0A 2MGPA 1IQJL 2P93L 2W2NE 2YGQA 3HS5A 2DDUA 1EMNA 2UWPB 1V3XB 2J38B 3R05A 1IOXA 4PH9A 3ZYJB 1L3YA 4OTYA 3V64C 1MQ6L 1DVAL 1M1XB 1PXXA 2VVUL 3KRKA 6COXA 4GU3A 2F9BL 1CCVA 4Y6DB 2EI6B 4JZFL 2XBWL 4Z0KB 1XKAL 4CUDA 2BOUA 4C16A 4X8SL 1F0RB 3FBYA 3FCSB 3HS6A 3KQBL 2WPKE 3NJPC 4X8VL 2VWOL 3KQCL 1YO8A 4XBMA 3HO4A 4TGFA 4X8UL 5K0HB 2J34B 2JKHL 5IKVA 1JL9A 1NFWB 1JV2B 1EPJA 1PGEA 2KNIA 3S6XA 1UZKA 2BT7A 1G1RA 1EBVA 3GCWE 3P5BL 2W86A 2YGPA 2XC4L 1YGCL 4RUTA 2W3IB 1ATDA 4CUEA 1EMOA 2J4IB 3ZYGA 2KV4A 2Q1JB 4ZHAB 1APQA 3HPTA 1XKBA 1JBUL 1F7EA 1URKA 1COUA 1AUTL 1KIGL 3GISX 4YT6L 3TK5B 2W2OE 1ADXA 2RNLA 3KQEL 1CX2A 1O5DL 4FM5A 1EAIC 2FLRL 3NTBA 5E8DA 4O1ZA 4BXSA 3F1SB 3CFWA 1NFYB 1G1QA 3TZIA 4ISHL 2WPHE 2WYGB 2OYEP 2OYUP 4LMFA 1X7AL 1BF9A 1HAFA 2P26A 2WPLE 4BTTA 3HO3A 4Z6AL 3IITB 1IQLL 3QMOA 1I0UA 2K2TA 3ENSA 2H9EL 4BTIA 2VH0B 1EZQB 4MMXB 2FD6A 1PRHA 1FAXL 2BOXA 2PR3B 2B7DL 5L30L 1G1TA 4JYVL 4MMZB 1EGFA 5CKMA 2XC0L 3QCWA 3LIWB 4Y79B 5EGMB 3N8YA 5CKQA 4D0EA 3M37L 4JZDL 3DEMA 1MOXC 2BQ6A 1XDTR 2TGFA 1U67A 4RRYA 2P95L 2Y5HL 5JVZA 2GD4A 2WYJB 1DQBA 2ADXA 4YZUB 3HS7A 3U7UG 1WHEA 4NGAL 5F1AA 5L2YL 4M10A 4RRXA 4A94C 2FZZL 3LTFB 1PFXL 2M74A 1CCFA 2P3FN 2KB9A 1CEJA 1IJQA 3OLTA 1KLJL 1IQFL 1B9WA 1J9CL 2WPIE 4BDXA 2EI8B 3SOBB 1FAKL 2WG3C 3NTGA 1IOEL 1TPGA 1IQEL 4MMYB 3LN0A 2HOXA 1EQGA 3NT1A 1FE2A 3H5CB 2BOHA 1ATBA 1LPGA 1PTHA 2BQ7A 2Y7XB 1A3PA 2PUQL 3SW2A 1IVOC 1F0SB 4YT7L 1W8BL 1NQLB 1SZBA 2VRSA 4RRZA 2JJLA 1DDXA 3U73A 5KN5C 2WPJE 2WG4B 2VWNL 1TOZA 2XBVL 3Q7DA 2CJIB 2Y82B 1F7MA 4ZAEB 3SOVA 2BOKL 1IQKL 2MHPA 5FDQA 3BT2A 3CS7L 1K37A 1C5MF 2Y7ZB 1HT5A 3BT1A 3HO5A 1LMMA 2RA0L 1V1HA 4BTUA 1IP0A 1NZIA 1WU1B 3MQEA 1EPHA 2J2UB 1ATEA 2Y5GL 1NFXB 3IJEB 3KQDL 2BZ6L 3K9XA 2WPME
chains in the Genus database with same CATH topology
4NA9L 1HRFA 1P0SL 3KCGL 1RFNB 4JYUL 3MDLA 1LPZA 2FLBL 4ISIL 4AQTA 2PHBB 2P94L 1DIYA 2H9EC 2UWLB 3PGHA 1KLIL 5JBBE 4BXWA 3N8YB 3LAQA 1HX2A 5JVYA 3OLUA 2WZPP 5IKQA 2W3KB 2VJ3A 3POYA 1UZJA 1CVUA 1Z6CA 2MGRA 2D1JB 5IKRA 4BDWA 5KIRA 2K2SB 1G2LB 5CISA 4M11A 3GCXE 1HT8A 1TLEA 3M36L 1FFMA 4X8TL 2FLGA 2Y38A 2G00L 2J94B 3TK6B 1HREA 3C9AC 3RR3A 1IQNL 1LMJA 3ELAL 2VWMK 3F6UL 3BPSE 1ATAA 5F19A 4E1GA 4Z0LA 2VVVL 1G1SA 4ZXXL 2P16L 4ZH8B 3ASIA 4RS0A 3N8XA 2P3TA 1FF7A 2KL7A 3TBDA 2XBXL 5JB9E 1G2MB 3TGFA 1DX5I 3V65B 1HJ7A 1IQGL 2P3UA 1EPIA 1HCGB 3LC3B 3EGFA 2Y80B 3LC5B 1QFKL 4Y76B 5JBCE 1HZ8A 4D0FA 1P9JA 1IQHL 2P3FL 1WHFA 4A7IA 4G1MB 2VWLL 2XC5L 2W2ME 1IGZA 2WFTA 5L2ZL 4XLWA 1YUGA 1EPGA 2VH6B 1CQEA 3KK6A 1IQIL 3FFGL 4LORA 4O02B 2AYLA 5I46L 3TH3L 1N1IA 1YUFA 1GK5A 3N8WB 2BMGA 2P28B 4COXA 1CVWL 1FJSL 3Q3KB 5COXA 1IQML 5IKTA 4JZEL 1L5GB 5JB8E 3N8ZA 1KSNB 1MQ5L 4CSYA 1IGXA 1Q4GA 4ZXYL 2YGOA 2VVCK 2W2PE 3LTGD 3N8WA 2I9AA 1NT0A 1ZAQA 2I9BA 3ZYIB 4OTJA 3CENL 4CUFA 1LPKA 2W2QE 1U8CB 1OB1C 1EQHA 4Y7AB 2BO2A 1Z6EL 2EI7B 1APOA 2Y5FL 2W26B 3N8VA 1FSBA 1NFUB 5CKNA 1W7XL 2WFXB 5JBAE 1LQDA 4NG9L 1KLOA 2UWOB 4XL1A 2BQWA 1YUKB 1UZQA 4Y7BB 3SOQA 1XFEA 2XBYL 4Y71B 1HAEA 5JW1A 2NPRA 2Y81B 4RRWA 1NPEB 4D90A 3LN1A 2J95B 3CA7A 1UZPA 1K36A 2RHPA 3KL6B 1N7DA 3QH0A 2MGPA 1IQJL 2P93L 2W2NE 2YGQA 3HS5A 2DDUA 1EMNA 2UWPB 1V3XB 2J38B 3R05A 1IOXA 4PH9A 3ZYJB 1L3YA 4OTYA 3V64C 1MQ6L 1DVAL 1M1XB 1PXXA 2VVUL 3KRKA 6COXA 2F9BL 1CCVA 4Y6DB 2EI6B 4JZFL 2XBWL 4Z0KB 1XKAL 4CUDA 2BOUA 4C16A 4X8SL 1F0RB 3FBYA 3FCSB 3HS6A 3KQBL 2WPKE 3NJPC 4X8VL 2VWOL 3KQCL 1YO8A 4XBMA 3HO4A 4TGFA 4X8UL 5K0HB 2J34B 2JKHL 5IKVA 1JL9A 1NFWB 1JV2B 1EPJA 1PGEA 2KNIA 3S6XA 1UZKA 1G1RA 1EBVA 3GCWE 3P5BL 2W86A 2YGPA 2XC4L 1YGCL 4RUTA 2W3IB 1ATDA 4CUEA 1EMOA 2J4IB 3ZYGA 2KV4A 2Q1JB 4ZHAB 1APQA 3HPTA 1XKBA 1JBUL 1F7EA 1URKA 1COUA 1AUTL 1KIGL 3GISX 4YT6L 3TK5B 2W2OE 1ADXA 2RNLA 3KQEL 1CX2A 1O5DL 4FM5A 1EAIC 2FLRL 3NTBA 5E8DA 4O1ZA 4BXSA 3F1SB 3CFWA 1NFYB 1G1QA 3TZIA 4ISHL 2WPHE 2WYGB 2OYEP 2OYUP 4LMFA 1X7AL 1BF9A 1HAFA 2P26A 2WPLE 4BTTA 3HO3A 4Z6AL 3IITB 1IQLL 3QMOA 1I0UA 2K2TA 3ENSA 2H9EL 4BTIA 2VH0B 1EZQB 4MMXB 2FD6A 1PRHA 1FAXL 2BOXA 2PR3B 2B7DL 5L30L 1G1TA 4JYVL 4MMZB 1EGFA 5CKMA 2XC0L 3QCWA 3LIWB 4Y79B 5EGMB 3N8YA 5CKQA 4D0EA 3M37L 4JZDL 3DEMA 1MOXC 2BQ6A 1XDTR 2TGFA 1U67A 4RRYA 2P95L 2Y5HL 5JVZA 2GD4A 2WYJB 1DQBA 2ADXA 4YZUB 3HS7A 3U7UG 1WHEA 4NGAL 5F1AA 5L2YL 4M10A 4RRXA 4A94C 2FZZL 3LTFB 1PFXL 2M74A 1CCFA 2P3FN 2KB9A 1CEJA 1IJQA 3OLTA 1KLJL 1IQFL 1B9WA 1J9CL 2WPIE 4BDXA 2EI8B 3SOBB 1FAKL 2WG3C 3NTGA 1IOEL 1TPGA 1IQEL 4MMYB 3LN0A 1EQGA 3NT1A 1FE2A 3H5CB 2BOHA 1ATBA 1LPGA 1PTHA 2BQ7A 2Y7XB 1A3PA 2PUQL 3SW2A 1IVOC 1F0SB 4YT7L 1W8BL 1NQLB 1SZBA 4RRZA 1DDXA 3U73A 5KN5C 2WPJE 2WG4B 2VWNL 1TOZA 2XBVL 3Q7DA 2CJIB 2Y82B 1F7MA 4ZAEB 3SOVA 2BOKL 1IQKL 2MHPA 5FDQA 3BT2A 3CS7L 1K37A 1C5MF 2Y7ZB 1HT5A 3BT1A 3HO5A 1LMMA 2RA0L 4BTUA 1IP0A 1NZIA 1WU1B 3MQEA 1EPHA 2J2UB 1ATEA 2Y5GL 1NFXB 3IJEB 3KQDL 2BZ6L 3K9XA 2WPME
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4NA9 L;  1HRF A;  1P0S L;  3KCG L;  1RFN B;  4JYU L;  3MDL A;  1LPZ A;  2FLB L;  4ISI L;  4AQT A;  2PHB B;  2P94 L;  1DIY A;  2UWL B;  3PGH A;  1KLI L;  5JBB E;  4BXW A;  3N8Y B;  3LAQ A;  1HX2 A;  5JVY A;  3OLU A;  5IKQ A;  2W3K B;  2VJ3 A;  3POY A;  1UZJ A;  1CVU A;  1Z6C A;  2MGR A;  2D1J B;  5IKR A;  4BDW A;  5KIR A;  2K2S B;  1G2L B;  5CIS A;  4M11 A;  3GCX E;  1HT8 A;  1TLE A;  3M36 L;  1FFM A;  4X8T L;  2FLG A;  2Y38 A;  2G00 L;  2J94 B;  3TK6 B;  1HRE A;  3C9A C;  3RR3 A;  1IQN L;  1LMJ A;  3ELA L;  2VWM K;  3F6U L;  3BPS E;  1ATA A;  5F19 A;  4E1G A;  4Z0L A;  2VVV L;  1G1S A;  4ZXX L;  2P16 L;  4ZH8 B;  3ASI A;  4RS0 A;  3N8X A;  2P3T A;  1FF7 A;  2KL7 A;  3TBD A;  2XBX L;  5JB9 E;  1G2M B;  3TGF A;  1DX5 I;  3V65 B;  1HJ7 A;  1IQG L;  2P3U A;  1EPI A;  1HCG B;  3LC3 B;  3EGF A;  2Y80 B;  3LC5 B;  1QFK L;  4Y76 B;  5JBC E;  1HZ8 A;  4D0F A;  1P9J A;  1IQH L;  2P3F L;  1WHF A;  4A7I A;  4G1M B;  2VWL L;  2XC5 L;  2W2M E;  1IGZ A;  2WFT A;  5L2Z L;  4XLW A;  1YUG A;  1EPG A;  2VH6 B;  1CQE A;  3KK6 A;  1IQI L;  3FFG L;  4LOR A;  4O02 B;  2AYL A;  5I46 L;  3TH3 L;  1N1I A;  1YUF A;  1GK5 A;  3N8W B;  2BMG A;  2P28 B;  4COX A;  1CVW L;  1FJS L;  3Q3K B;  5COX A;  1IQM L;  5IKT A;  4JZE L;  1L5G B;  5JB8 E;  3N8Z A;  1KSN B;  1MQ5 L;  4CSY A;  1IGX A;  1Q4G A;  4ZXY L;  2YGO A;  2VVC K;  2W2P E;  3LTG D;  3N8W A;  2I9A A;  1NT0 A;  1ZAQ A;  2I9B A;  3ZYI B;  4OTJ A;  3CEN L;  4CUF A;  1LPK A;  2W2Q E;  1U8C B;  1OB1 C;  1EQH A;  4Y7A B;  2BO2 A;  1Z6E L;  2EI7 B;  1APO A;  2Y5F L;  2W26 B;  3N8V A;  1FSB A;  1NFU B;  5CKN A;  1W7X L;  2WFX B;  5JBA E;  1LQD A;  4NG9 L;  1KLO A;  2UWO B;  4XL1 A;  2BQW A;  1YUK B;  1UZQ A;  4Y7B B;  3SOQ A;  1XFE A;  2XBY L;  4Y71 B;  1HAE A;  5JW1 A;  2NPR A;  2Y81 B;  4RRW A;  1NPE B;  4D90 A;  3LN1 A;  2J95 B;  3CA7 A;  1UZP A;  1K36 A;  2RHP A;  3KL6 B;  1N7D A;  3QH0 A;  2MGP A;  1IQJ L;  2P93 L;  2W2N E;  3HS5 A;  2DDU A;  1EMN A;  2UWP B;  1V3X B;  2J38 B;  3R05 A;  1IOX A;  4PH9 A;  3ZYJ B;  1L3Y A;  4OTY A;  3V64 C;  1MQ6 L;  1DVA L;  1M1X B;  1PXX A;  2VVU L;  3KRK A;  6COX A;  2F9B L;  1CCV A;  4Y6D B;  2EI6 B;  4JZF L;  2XBW L;  4Z0K B;  1XKA L;  4CUD A;  2BOU A;  4C16 A;  4X8S L;  1F0R B;  3FBY A;  3FCS B;  3HS6 A;  3KQB L;  2WPK E;  3NJP C;  4X8V L;  2VWO L;  3KQC L;  1YO8 A;  4XBM A;  3HO4 A;  4TGF A;  4X8U L;  5K0H B;  2J34 B;  2JKH L;  5IKV A;  1JL9 A;  1NFW B;  1JV2 B;  1EPJ A;  1PGE A;  1UZK A;  1G1R A;  1EBV A;  3GCW E;  3P5B L;  2W86 A;  2YGP A;  2XC4 L;  1YGC L;  4RUT A;  2W3I B;  1ATD A;  4CUE A;  1EMO A;  2J4I B;  3ZYG A;  2KV4 A;  2Q1J B;  4ZHA B;  1APQ A;  3HPT A;  1XKB A;  1JBU L;  1F7E A;  1URK A;  1COU A;  1AUT L;  1KIG L;  3GIS X;  4YT6 L;  3TK5 B;  2W2O E;  1ADX A;  2RNL A;  3KQE L;  1CX2 A;  1O5D L;  4FM5 A;  1EAI C;  2FLR L;  3NTB A;  5E8D A;  4O1Z A;  4BXS A;  3F1S B;  3CFW A;  1NFY B;  1G1Q A;  3TZI A;  4ISH L;  2WPH E;  2WYG B;  2OYE P;  2OYU P;  4LMF A;  1X7A L;  1BF9 A;  1HAF A;  2P26 A;  2WPL E;  4BTT A;  3HO3 A;  4Z6A L;  3IIT B;  1IQL L;  3QMO A;  1I0U A;  2K2T A;  3ENS A;  2H9E L;  4BTI A;  2VH0 B;  1EZQ B;  4MMX B;  2FD6 A;  1PRH A;  1FAX L;  2BOX A;  2PR3 B;  2B7D L;  5L30 L;  1G1T A;  4JYV L;  4MMZ B;  1EGF A;  5CKM A;  2XC0 L;  3QCW A;  3LIW B;  4Y79 B;  5EGM B;  3N8Y A;  5CKQ A;  4D0E A;  3M37 L;  4JZD L;  3DEM A;  1MOX C;  2BQ6 A;  1XDT R;  2TGF A;  1U67 A;  4RRY A;  2P95 L;  2Y5H L;  5JVZ A;  2GD4 A;  2WYJ B;  1DQB A;  2ADX A;  4YZU B;  3HS7 A;  3U7U G;  1WHE A;  4NGA L;  5F1A A;  5L2Y L;  4M10 A;  4RRX A;  2FZZ L;  3LTF B;  1PFX L;  2M74 A;  1CCF A;  2P3F N;  2KB9 A;  1CEJ A;  1IJQ A;  3OLT A;  1KLJ L;  1IQF L;  1B9W A;  1J9C L;  2WPI E;  4BDX A;  2EI8 B;  3SOB B;  1FAK L;  2WG3 C;  3NTG A;  1IOE L;  1TPG A;  1IQE L;  4MMY B;  3LN0 A;  1EQG A;  3NT1 A;  1FE2 A;  3H5C B;  2BOH A;  1ATB A;  1LPG A;  1PTH A;  2BQ7 A;  2Y7X B;  1A3P A;  2PUQ L;  3SW2 A;  1IVO C;  1F0S B;  4YT7 L;  1W8B L;  1NQL B;  1SZB A;  4RRZ A;  1DDX A;  3U73 A;  5KN5 C;  2WPJ E;  2WG4 B;  2VWN L;  1TOZ A;  2XBV L;  3Q7D A;  2CJI B;  2Y82 B;  1F7M A;  4ZAE B;  3SOV A;  2BOK L;  1IQK L;  2MHP A;  5FDQ A;  3BT2 A;  3CS7 L;  1K37 A;  1C5M F;  2Y7Z B;  1HT5 A;  3BT1 A;  3HO5 A;  2RA0 L;  4BTU A;  1IP0 A;  1NZI A;  1WU1 B;  3MQE A;  1EPH A;  2J2U B;  1ATE A;  2Y5G L;  1NFX B;  3IJE B;  3KQD L;  2BZ6 L;  3K9X A;  2WPM E; 
#chains in the Genus database with same CATH topology
 4NA9 L;  1HRF A;  1P0S L;  3KCG L;  1RFN B;  4JYU L;  3MDL A;  1LPZ A;  2FLB L;  4ISI L;  4AQT A;  2PHB B;  2P94 L;  1DIY A;  2H9E C;  2UWL B;  3PGH A;  1KLI L;  5JBB E;  4BXW A;  3N8Y B;  3LAQ A;  1HX2 A;  5JVY A;  3OLU A;  2WZP P;  5IKQ A;  2W3K B;  1V1I A;  2VJ3 A;  3POY A;  1UZJ A;  1CVU A;  1Z6C A;  2MGR A;  2D1J B;  5IKR A;  4BDW A;  5KIR A;  2K2S B;  1G2L B;  5CIS A;  4M11 A;  3GCX E;  2BSF A;  1HT8 A;  1TLE A;  3M36 L;  1FFM A;  4X8T L;  2FLG A;  4GU4 A;  2Y38 A;  2G00 L;  2J94 B;  3TK6 B;  1HRE A;  3C9A C;  3RR3 A;  1IQN L;  1LMJ A;  3ELA L;  2VWM K;  3F6U L;  1LK9 A;  3BPS E;  1ATA A;  5F19 A;  4E1G A;  4Z0L A;  2VVV L;  1G1S A;  4ZXX L;  2P16 L;  4ZH8 B;  3ASI A;  4RS0 A;  3N8X A;  2P3T A;  1FF7 A;  2KL7 A;  3TBD A;  2XBX L;  5JB9 E;  1G2M B;  3TGF A;  1DX5 I;  3V65 B;  1HJ7 A;  1IQG L;  2P3U A;  1EPI A;  1HCG B;  3LC3 B;  3EGF A;  2Y80 B;  3LC5 B;  1QFK L;  4Y76 B;  5JBC E;  1HZ8 A;  4D0F A;  1P9J A;  1IQH L;  2P3F L;  1WHF A;  4A7I A;  4G1M B;  2HOR A;  2VWL L;  2XC5 L;  2W2M E;  1IGZ A;  2WFT A;  5L2Z L;  4XLW A;  1YUG A;  1EPG A;  2VH6 B;  1CQE A;  3KK6 A;  1IQI L;  3FFG L;  4LOR A;  4O02 B;  2AYL A;  5I46 L;  3TH3 L;  1N1I A;  1YUF A;  1GK5 A;  3N8W B;  2BMG A;  2P28 B;  4COX A;  1CVW L;  1FJS L;  3Q3K B;  5COX A;  1IQM L;  5IKT A;  4JZE L;  1L5G B;  5JB8 E;  3N8Z A;  1KSN B;  1MQ5 L;  4CSY A;  1IGX A;  1Q4G A;  2BT8 A;  4ZXY L;  2YGO A;  2VVC K;  2W2P E;  3LTG D;  3N8W A;  2I9A A;  1NT0 A;  1ZAQ A;  2I9B A;  3ZYI B;  4OTJ A;  3CEN L;  4CUF A;  1LPK A;  2W2Q E;  1U8C B;  1OB1 C;  1QIU A;  1EQH A;  4Y7A B;  2BO2 A;  1Z6E L;  2EI7 B;  1APO A;  2Y5F L;  2W26 B;  3N8V A;  1FSB A;  1NFU B;  5CKN A;  1W7X L;  2WFX B;  5JBA E;  1LQD A;  4NG9 L;  1KLO A;  2UWO B;  4XL1 A;  2BQW A;  1YUK B;  1UZQ A;  4Y7B B;  3SOQ A;  1XFE A;  2XBY L;  4Y71 B;  1HAE A;  5JW1 A;  2NPR A;  2Y81 B;  4RRW A;  1NPE B;  4D90 A;  3LN1 A;  2J95 B;  3CA7 A;  1UZP A;  1K36 A;  3KL6 B;  1KKE A;  2RHP A;  1N7D A;  3QH0 A;  2MGP A;  1IQJ L;  2P93 L;  2W2N E;  2YGQ A;  3HS5 A;  2DDU A;  1EMN A;  2UWP B;  1V3X B;  2J38 B;  3R05 A;  1IOX A;  4PH9 A;  3ZYJ B;  1L3Y A;  4OTY A;  3V64 C;  1MQ6 L;  1DVA L;  1M1X B;  1PXX A;  2VVU L;  3KRK A;  6COX A;  4GU3 A;  2F9B L;  1CCV A;  4Y6D B;  2EI6 B;  4JZF L;  2XBW L;  4Z0K B;  1XKA L;  4CUD A;  2BOU A;  4C16 A;  4X8S L;  1F0R B;  3FBY A;  3FCS B;  3HS6 A;  3KQB L;  2WPK E;  3NJP C;  4X8V L;  2VWO L;  3KQC L;  1YO8 A;  4XBM A;  3HO4 A;  4TGF A;  4X8U L;  5K0H B;  2J34 B;  2JKH L;  5IKV A;  1JL9 A;  1NFW B;  1JV2 B;  1EPJ A;  1PGE A;  2KNI A;  3S6X A;  1UZK A;  2BT7 A;  1G1R A;  1EBV A;  3GCW E;  3P5B L;  2W86 A;  2YGP A;  2XC4 L;  1YGC L;  4RUT A;  2W3I B;  1ATD A;  4CUE A;  1EMO A;  2J4I B;  3ZYG A;  2KV4 A;  2Q1J B;  4ZHA B;  1APQ A;  3HPT A;  1XKB A;  1JBU L;  1F7E A;  1URK A;  1COU A;  1AUT L;  1KIG L;  3GIS X;  4YT6 L;  3TK5 B;  2W2O E;  1ADX A;  2RNL A;  3KQE L;  1CX2 A;  1O5D L;  4FM5 A;  1EAI C;  2FLR L;  3NTB A;  5E8D A;  4O1Z A;  4BXS A;  3F1S B;  3CFW A;  1NFY B;  1G1Q A;  3TZI A;  4ISH L;  2WPH E;  2WYG B;  2OYE P;  2OYU P;  4LMF A;  1X7A L;  1BF9 A;  1HAF A;  2P26 A;  2WPL E;  4BTT A;  3HO3 A;  4Z6A L;  3IIT B;  1IQL L;  3QMO A;  1I0U A;  2K2T A;  3ENS A;  2H9E L;  4BTI A;  2VH0 B;  1EZQ B;  4MMX B;  2FD6 A;  1PRH A;  1FAX L;  2BOX A;  2PR3 B;  2B7D L;  5L30 L;  1G1T A;  4JYV L;  4MMZ B;  1EGF A;  5CKM A;  2XC0 L;  3QCW A;  3LIW B;  4Y79 B;  5EGM B;  3N8Y A;  5CKQ A;  4D0E A;  3M37 L;  4JZD L;  3DEM A;  1MOX C;  2BQ6 A;  1XDT R;  2TGF A;  1U67 A;  4RRY A;  2P95 L;  2Y5H L;  5JVZ A;  2GD4 A;  2WYJ B;  1DQB A;  2ADX A;  4YZU B;  3HS7 A;  3U7U G;  1WHE A;  4NGA L;  5F1A A;  5L2Y L;  4M10 A;  4RRX A;  4A94 C;  2FZZ L;  3LTF B;  1PFX L;  2M74 A;  1CCF A;  2P3F N;  2KB9 A;  1CEJ A;  1IJQ A;  3OLT A;  1KLJ L;  1IQF L;  1B9W A;  1J9C L;  2WPI E;  4BDX A;  2EI8 B;  3SOB B;  1FAK L;  2WG3 C;  3NTG A;  1IOE L;  1TPG A;  1IQE L;  4MMY B;  3LN0 A;  2HOX A;  1EQG A;  3NT1 A;  1FE2 A;  3H5C B;  2BOH A;  1ATB A;  1LPG A;  1PTH A;  2BQ7 A;  2Y7X B;  1A3P A;  2PUQ L;  3SW2 A;  1IVO C;  1F0S B;  4YT7 L;  1W8B L;  1NQL B;  1SZB A;  2VRS A;  4RRZ A;  2JJL A;  1DDX A;  3U73 A;  5KN5 C;  2WPJ E;  2WG4 B;  2VWN L;  1TOZ A;  2XBV L;  3Q7D A;  2CJI B;  2Y82 B;  1F7M A;  4ZAE B;  3SOV A;  2BOK L;  1IQK L;  2MHP A;  5FDQ A;  3BT2 A;  3CS7 L;  1K37 A;  1C5M F;  2Y7Z B;  1HT5 A;  3BT1 A;  3HO5 A;  1LMM A;  2RA0 L;  1V1H A;  4BTU A;  1IP0 A;  1NZI A;  1WU1 B;  3MQE A;  1EPH A;  2J2U B;  1ATE A;  2Y5G L;  1NFX B;  3IJE B;  3KQD L;  2BZ6 L;  3K9X A;  2WPM E; 
#chains in the Genus database with same CATH homology
 4NA9 L;  1HRF A;  1P0S L;  3KCG L;  1RFN B;  4JYU L;  3MDL A;  1LPZ A;  2FLB L;  4ISI L;  4AQT A;  2PHB B;  2P94 L;  1DIY A;  2H9E C;  2UWL B;  3PGH A;  1KLI L;  5JBB E;  4BXW A;  3N8Y B;  3LAQ A;  1HX2 A;  5JVY A;  3OLU A;  2WZP P;  5IKQ A;  2W3K B;  2VJ3 A;  3POY A;  1UZJ A;  1CVU A;  1Z6C A;  2MGR A;  2D1J B;  5IKR A;  4BDW A;  5KIR A;  2K2S B;  1G2L B;  5CIS A;  4M11 A;  3GCX E;  1HT8 A;  1TLE A;  3M36 L;  1FFM A;  4X8T L;  2FLG A;  2Y38 A;  2G00 L;  2J94 B;  3TK6 B;  1HRE A;  3C9A C;  3RR3 A;  1IQN L;  1LMJ A;  3ELA L;  2VWM K;  3F6U L;  3BPS E;  1ATA A;  5F19 A;  4E1G A;  4Z0L A;  2VVV L;  1G1S A;  4ZXX L;  2P16 L;  4ZH8 B;  3ASI A;  4RS0 A;  3N8X A;  2P3T A;  1FF7 A;  2KL7 A;  3TBD A;  2XBX L;  5JB9 E;  1G2M B;  3TGF A;  1DX5 I;  3V65 B;  1HJ7 A;  1IQG L;  2P3U A;  1EPI A;  1HCG B;  3LC3 B;  3EGF A;  2Y80 B;  3LC5 B;  1QFK L;  4Y76 B;  5JBC E;  1HZ8 A;  4D0F A;  1P9J A;  1IQH L;  2P3F L;  1WHF A;  4A7I A;  4G1M B;  2VWL L;  2XC5 L;  2W2M E;  1IGZ A;  2WFT A;  5L2Z L;  4XLW A;  1YUG A;  1EPG A;  2VH6 B;  1CQE A;  3KK6 A;  1IQI L;  3FFG L;  4LOR A;  4O02 B;  2AYL A;  5I46 L;  3TH3 L;  1N1I A;  1YUF A;  1GK5 A;  3N8W B;  2BMG A;  2P28 B;  4COX A;  1CVW L;  1FJS L;  3Q3K B;  5COX A;  1IQM L;  5IKT A;  4JZE L;  1L5G B;  5JB8 E;  3N8Z A;  1KSN B;  1MQ5 L;  4CSY A;  1IGX A;  1Q4G A;  4ZXY L;  2YGO A;  2VVC K;  2W2P E;  3LTG D;  3N8W A;  2I9A A;  1NT0 A;  1ZAQ A;  2I9B A;  3ZYI B;  4OTJ A;  3CEN L;  4CUF A;  1LPK A;  2W2Q E;  1U8C B;  1OB1 C;  1EQH A;  4Y7A B;  2BO2 A;  1Z6E L;  2EI7 B;  1APO A;  2Y5F L;  2W26 B;  3N8V A;  1FSB A;  1NFU B;  5CKN A;  1W7X L;  2WFX B;  5JBA E;  1LQD A;  4NG9 L;  1KLO A;  2UWO B;  4XL1 A;  2BQW A;  1YUK B;  1UZQ A;  4Y7B B;  3SOQ A;  1XFE A;  2XBY L;  4Y71 B;  1HAE A;  5JW1 A;  2NPR A;  2Y81 B;  4RRW A;  1NPE B;  4D90 A;  3LN1 A;  2J95 B;  3CA7 A;  1UZP A;  1K36 A;  2RHP A;  3KL6 B;  1N7D A;  3QH0 A;  2MGP A;  1IQJ L;  2P93 L;  2W2N E;  2YGQ A;  3HS5 A;  2DDU A;  1EMN A;  2UWP B;  1V3X B;  2J38 B;  3R05 A;  1IOX A;  4PH9 A;  3ZYJ B;  1L3Y A;  4OTY A;  3V64 C;  1MQ6 L;  1DVA L;  1M1X B;  1PXX A;  2VVU L;  3KRK A;  6COX A;  2F9B L;  1CCV A;  4Y6D B;  2EI6 B;  4JZF L;  2XBW L;  4Z0K B;  1XKA L;  4CUD A;  2BOU A;  4C16 A;  4X8S L;  1F0R B;  3FBY A;  3FCS B;  3HS6 A;  3KQB L;  2WPK E;  3NJP C;  4X8V L;  2VWO L;  3KQC L;  1YO8 A;  4XBM A;  3HO4 A;  4TGF A;  4X8U L;  5K0H B;  2J34 B;  2JKH L;  5IKV A;  1JL9 A;  1NFW B;  1JV2 B;  1EPJ A;  1PGE A;  2KNI A;  3S6X A;  1UZK A;  1G1R A;  1EBV A;  3GCW E;  3P5B L;  2W86 A;  2YGP A;  2XC4 L;  1YGC L;  4RUT A;  2W3I B;  1ATD A;  4CUE A;  1EMO A;  2J4I B;  3ZYG A;  2KV4 A;  2Q1J B;  4ZHA B;  1APQ A;  3HPT A;  1XKB A;  1JBU L;  1F7E A;  1URK A;  1COU A;  1AUT L;  1KIG L;  3GIS X;  4YT6 L;  3TK5 B;  2W2O E;  1ADX A;  2RNL A;  3KQE L;  1CX2 A;  1O5D L;  4FM5 A;  1EAI C;  2FLR L;  3NTB A;  5E8D A;  4O1Z A;  4BXS A;  3F1S B;  3CFW A;  1NFY B;  1G1Q A;  3TZI A;  4ISH L;  2WPH E;  2WYG B;  2OYE P;  2OYU P;  4LMF A;  1X7A L;  1BF9 A;  1HAF A;  2P26 A;  2WPL E;  4BTT A;  3HO3 A;  4Z6A L;  3IIT B;  1IQL L;  3QMO A;  1I0U A;  2K2T A;  3ENS A;  2H9E L;  4BTI A;  2VH0 B;  1EZQ B;  4MMX B;  2FD6 A;  1PRH A;  1FAX L;  2BOX A;  2PR3 B;  2B7D L;  5L30 L;  1G1T A;  4JYV L;  4MMZ B;  1EGF A;  5CKM A;  2XC0 L;  3QCW A;  3LIW B;  4Y79 B;  5EGM B;  3N8Y A;  5CKQ A;  4D0E A;  3M37 L;  4JZD L;  3DEM A;  1MOX C;  2BQ6 A;  1XDT R;  2TGF A;  1U67 A;  4RRY A;  2P95 L;  2Y5H L;  5JVZ A;  2GD4 A;  2WYJ B;  1DQB A;  2ADX A;  4YZU B;  3HS7 A;  3U7U G;  1WHE A;  4NGA L;  5F1A A;  5L2Y L;  4M10 A;  4RRX A;  4A94 C;  2FZZ L;  3LTF B;  1PFX L;  2M74 A;  1CCF A;  2P3F N;  2KB9 A;  1CEJ A;  1IJQ A;  3OLT A;  1KLJ L;  1IQF L;  1B9W A;  1J9C L;  2WPI E;  4BDX A;  2EI8 B;  3SOB B;  1FAK L;  2WG3 C;  3NTG A;  1IOE L;  1TPG A;  1IQE L;  4MMY B;  3LN0 A;  1EQG A;  3NT1 A;  1FE2 A;  3H5C B;  2BOH A;  1ATB A;  1LPG A;  1PTH A;  2BQ7 A;  2Y7X B;  1A3P A;  2PUQ L;  3SW2 A;  1IVO C;  1F0S B;  4YT7 L;  1W8B L;  1NQL B;  1SZB A;  4RRZ A;  1DDX A;  3U73 A;  5KN5 C;  2WPJ E;  2WG4 B;  2VWN L;  1TOZ A;  2XBV L;  3Q7D A;  2CJI B;  2Y82 B;  1F7M A;  4ZAE B;  3SOV A;  2BOK L;  1IQK L;  2MHP A;  5FDQ A;  3BT2 A;  3CS7 L;  1K37 A;  1C5M F;  2Y7Z B;  1HT5 A;  3BT1 A;  3HO5 A;  1LMM A;  2RA0 L;  4BTU A;  1IP0 A;  1NZI A;  1WU1 B;  3MQE A;  1EPH A;  2J2U B;  1ATE A;  2Y5G L;  1NFX B;  3IJE B;  3KQD L;  2BZ6 L;  3K9X A;  2WPM E; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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