2B7DL

Factor viia inhibitors: chemical optimization, preclinical pharmacokinetics, pharmacodynamics, and efficacy in a baboon thrombosis model
Total Genus 18
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
18
sequence length
94
structure length
94
Chain Sequence
QCASSPCQNGGSCKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILE
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Factor VIIa inhibitors: Chemical optimization, preclinical pharmacokinetics, pharmacodynamics, and efficacy in an arterial baboon thrombosis model.
pubmed doi rcsb
molecule tags Blood clotting
source organism Homo sapiens
molecule keywords Coagulation factor VII
total genus 18
structure length 94
sequence length 94
ec nomenclature ec 3.4.21.21: Coagulation factor VIIa.
pdb deposition date 2005-10-04

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
L PF00008 EGF EGF-like domain
L PF00594 Gla Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.25.10 Mainly Beta Ribbon Laminin Laminin 2b7dL02
2.10.25.10 Mainly Beta Ribbon Laminin Laminin 2b7dL01
1IOXA 5IKRA 1EMNA 2BOXA 4X8VL 1CVWL 3KCGL 4CSYA 2J95B 1K36A 1XKBA 3QCWA 2H9EL 3LTGD 2PR3B 2FLGA 2XC5L 1DX5I 2G00L 4YT7L 1EPGA 2MGPA 4BTIA 1PTHA 4RUTA 1Z6EL 2P3TA 3N8VA 1IJQA 1TPGA 3KQDL 1P9JA 4BDXA 1IQNL 3CENL 5F1AA 1G2LB 3LC3B 2WFXB 2Y7XB 3SOBB 5IKTA 3LC5B 4RRXA 1ATDA 4ISIL 1ATEA 3K9XA 4D0EA 3Q3KB 2UWOB 2XBVL 1WHFA 3QMOA 1FFMA 4E1GA 2UWLB 1WHEA 3SOVA 1Z6CA 6COXA 3CS7L 2Q1JB 2EI8B 2RHPA 1U67A 3FBYA 2VVCK 3HO5A 1G2MB 1LPKA 1JV2B 4JZDL 3FFGL 1FF7A 3CA7A 3LN1A 4AQTA 5JB8E 1EQHA 2PUQL 4RS0A 1HRFA 1IQFL 4RRYA 3KRKA 2YGOA 5CKQA 1DIYA 1F0SB 1EPIA 2JKHL 4CUDA 2DDUA 2VWOL 1NT0A 4Y7AB 2Y80B 1IQHL 1DQBA 2WPHE 2WFTA 2MHPA 1EPHA 1FSBA 5JB9E 2W2PE 2WPIE 4ISHL 2XBXL 3GCWE 4ZH8B 3LN0A 4RRZA 3NJPC 1UZKA 3TZIA 3OLUA 1FE2A 2TGFA 3N8WA 3M36L 3F6UL 1HZ8A 1V3XB 5EGMB 4TGFA 4BTUA 3IJEB 1ATBA 1YUFA 1K37A 2BZ6L 2WG3C 2XBYL 3BT1A 1IP0A 2WPKE 1IGZA 2UWPB 1UZJA 1B9WA 1L5GB 1I0UA 2W26B 3HO3A 5FDQA 2Y38A 2P3UA 4G1MB 3POYA 4LORA 1IQJL 3HO4A 4YZUB 4JZFL 5L30L 2P26A 1JBUL 1XFEA 1GK5A 1AUTL 2KB9A 2J38B 1PGEA 4Y79B 5F19A 3F1SB 3V65B 1F7MA 4LMFA 2W2OE 2W2NE 2KV4A 1HJ7A 2Y5GL 5JBAE 1KIGL 1UZQA 1KLIL 1EQGA 4D90A 2VVVL 3N8YA 5JVYA 1ZAQA 3QH0A 2MGRA 1PRHA 3U7UG 1U8CB 1MQ6L 1F0RB 3KQEL 1G1TA 1MOXC 1N7DA 3H5CB 3BT2A 1W8BL 2Y7ZB 3ZYJB 5JBCE 2F9BL 2J34B 1BF9A 1PFXL 3LTFB 4JYVL 1FAKL 3P5BL 1G1QA 1CQEA 1O5DL 1IVOC 1N1IA 3HS5A 1URKA 1IGXA 2AYLA 2Y82B 1NFWB 5K0HB 1LPZA 2VWLL 1DDXA 2J94B 4O02B 5KIRA 1YUKB 4Y76B 1KLOA 3SW2A 4BXWA 4Y71B 4ZXYL 3RR3A 4NGAL 2RNLA 5CKNA 1FJSL 1IQKL 4XL1A 4ZHAB 3HS6A 4OTYA 2VJ3A 3ZYGA 3LIWB 1LQDA 3N8ZA 3N8XA 1IQGL 2Y5FL 1EZQB 2XC0L 3NT1A 2BMGA 4MMZB 2D1JB 2KL7A 2EI7B 2W3KB 2K2SB 3SOQA 4Y7BB 1CVUA 1IQEL 3BPSE 1NFUB 1HX2A 1ATAA 3TH3L 2VWMK 2P28B 5L2YL 1CCVA 3ZYIB 4JYUL 2FD6A 4BTTA 3N8WB 4MMYB 2WYJB 1Q4GA 2CJIB 3FCSB 3CFWA 5I46L 5JBBE 2FLBL 4CUFA 3PGHA 1QFKL 2EI6B 4RRWA 3TK5B 1HAFA 3TK6B 1IOEL 1HT5A 4D0FA 1ADXA 3LAQA 5IKQA 3GCXE 1NFYB 4FM5A 1IQML 5IKVA 1FAXL 1W7XL 1TOZA 2P94L 2J2UB 1J9CL 1HT8A 2J4IB 1CEJA 1NFXB 5COXA 1JL9A 4C16A 1CX2A 3HPTA 3MQEA 2I9BA 1LPGA 1RFNB 2WG4B 4BDWA 4PH9A 2P95L 3EGFA 1NPEB 4CUEA 4Y6DB 4Z6AL 3MDLA 3KQCL 2OYEP 2W2QE 1YO8A 2YGPA 1HCGB 3N8YB 1APQA 2BO2A 4XLWA 3NTBA 2WPME 2BQ7A 2NPRA 4COXA 5L2ZL 5CKMA 1XDTR 2WPJE 3C9AC 1NQLB 3HS7A 4O1ZA 3ELAL 1YUGA 2I9AA 2PHBB 3ASIA 3OLTA 2WPLE 2M74A 1C5MF 2GD4A 2W86A 3KQBL 1TLEA 1YGCL 3Q7DA 5KN5C 2BQWA 2OYUP 4ZAEB 2BOKL 2WYGB 2FLRL 1KSNB 1IQIL 1MQ5L 1XKAL 1PXXA 3U73A 2P93L 3M37L 4XBMA 3GISX 2FZZL 4M11A 2Y5HL 2XC4L 4NG9L 5E8DA 2W2ME 1G1SA 2P3FN 2B7DL 1F7EA 5JW1A 1DVAL 4JZEL 1UZPA 4A7IA 4MMXB 5CISA 1HREA 2VH0B 1P0SL 1HAEA 1APOA 3R05A 1IQLL 5JVZA 4BXSA 2BOHA 4X8UL 3NTGA 1NZIA 1LMJA 3ENSA 3TBDA 1EPJA 4X8SL 3KL6B 4ZXXL 1EBVA 2W3IB 4OTJA 2ADXA 3DEMA 4X8TL 4NA9L 3IITB 1SZBA 2P3FL 3KK6A 1KLJL 2Y81B 1G1RA 1L3YA 4Z0KB 1EGFA 2VVUL 1COUA 2VH6B 1M1XB 1WU1B 4YT6L 2VWNL 2BQ6A 2K2TA 3V64C 3TGFA 4M10A 1CCFA 1EMOA 2BOUA 2XBWL 4Z0LA 2P16L 1X7AL 1OB1C 1A3PA 1EAIC 2RA0L
chains in the Genus database with same CATH superfamily
1IOXA 5IKRA 2KNIA 1EMNA 2BOXA 4X8VL 1CVWL 3KCGL 4CSYA 2BT7A 2J95B 1K36A 1XKBA 3QCWA 2H9EL 3LTGD 2PR3B 2FLGA 2XC5L 1DX5I 2G00L 4YT7L 1EPGA 2MGPA 3S6XA 4BTIA 1PTHA 4RUTA 1Z6EL 2P3TA 3N8VA 1IJQA 1TPGA 3KQDL 1P9JA 4A94C 4BDXA 2WZPP 1IQNL 3CENL 5F1AA 1G2LB 2YGQA 1QIUA 3LC3B 2WFXB 2Y7XB 3SOBB 5IKTA 4GU4A 3LC5B 4RRXA 1ATDA 4ISIL 1ATEA 3K9XA 4D0EA 3Q3KB 2UWOB 2BSFA 2XBVL 1WHFA 3QMOA 1FFMA 4E1GA 2UWLB 1WHEA 3SOVA 1Z6CA 6COXA 3CS7L 2Q1JB 2EI8B 2RHPA 1U67A 3FBYA 2VVCK 3HO5A 1G2MB 1LPKA 1JV2B 4JZDL 3FFGL 1FF7A 3CA7A 3LN1A 4AQTA 5JB8E 1EQHA 2PUQL 4RS0A 1HRFA 1IQFL 4RRYA 3KRKA 2YGOA 2H9EC 5CKQA 1DIYA 1F0SB 1EPIA 2JKHL 4CUDA 2DDUA 2VWOL 1NT0A 4Y7AB 2Y80B 1IQHL 1DQBA 2WPHE 2WFTA 2MHPA 1EPHA 1FSBA 5JB9E 2W2PE 2WPIE 4ISHL 2XBXL 3GCWE 4ZH8B 3LN0A 4RRZA 3NJPC 1UZKA 3TZIA 3OLUA 1FE2A 2TGFA 3N8WA 3M36L 3F6UL 1HZ8A 1V3XB 5EGMB 4TGFA 4BTUA 3IJEB 1ATBA 1YUFA 1K37A 2BZ6L 2WG3C 2XBYL 3BT1A 1IP0A 2WPKE 1IGZA 2UWPB 1UZJA 1B9WA 1L5GB 1I0UA 2W26B 3HO3A 5FDQA 2Y38A 2P3UA 4G1MB 3POYA 4LORA 1IQJL 3HO4A 4YZUB 4JZFL 5L30L 2P26A 1JBUL 1XFEA 1GK5A 1AUTL 2KB9A 2J38B 1LMMA 1PGEA 4Y79B 5F19A 3F1SB 3V65B 1F7MA 4LMFA 2W2OE 2W2NE 2KV4A 1HJ7A 2Y5GL 5JBAE 1KIGL 1UZQA 1KLIL 1EQGA 4D90A 2VVVL 3N8YA 5JVYA 1ZAQA 3QH0A 2MGRA 1PRHA 3U7UG 1U8CB 1MQ6L 1F0RB 3KQEL 1G1TA 1MOXC 1N7DA 3H5CB 3BT2A 1W8BL 2Y7ZB 3ZYJB 5JBCE 2F9BL 2J34B 1BF9A 1PFXL 3LTFB 4JYVL 1FAKL 3P5BL 1G1QA 1CQEA 1O5DL 1IVOC 1N1IA 2BT8A 3HS5A 1URKA 1IGXA 2AYLA 2Y82B 1V1IA 1NFWB 5K0HB 1LPZA 2VWLL 1DDXA 2J94B 2HOXA 4GU3A 4O02B 5KIRA 1YUKB 4Y76B 1KLOA 3SW2A 4BXWA 4Y71B 4ZXYL 3RR3A 4NGAL 2RNLA 5CKNA 1FJSL 1IQKL 4XL1A 4ZHAB 3HS6A 4OTYA 2VJ3A 3ZYGA 3LIWB 1LQDA 3N8ZA 3N8XA 1IQGL 2Y5FL 1EZQB 2XC0L 3NT1A 2BMGA 4MMZB 2D1JB 2KL7A 2EI7B 2W3KB 2K2SB 3SOQA 4Y7BB 1CVUA 1IQEL 3BPSE 2HORA 1NFUB 1HX2A 1ATAA 3TH3L 2VWMK 2P28B 5L2YL 1CCVA 1KKEA 3ZYIB 4JYUL 2FD6A 4BTTA 3N8WB 4MMYB 2WYJB 1Q4GA 2CJIB 3FCSB 3CFWA 5I46L 5JBBE 2FLBL 4CUFA 3PGHA 1QFKL 2EI6B 4RRWA 3TK5B 1HAFA 1V1HA 3TK6B 1IOEL 1HT5A 4D0FA 1ADXA 3LAQA 5IKQA 3GCXE 1NFYB 4FM5A 1IQML 5IKVA 1FAXL 1W7XL 1TOZA 2P94L 2J2UB 1J9CL 1HT8A 2J4IB 1CEJA 1NFXB 5COXA 1JL9A 4C16A 1CX2A 3HPTA 3MQEA 2I9BA 1LPGA 2VRSA 1RFNB 2WG4B 4BDWA 4PH9A 2P95L 3EGFA 1NPEB 4CUEA 4Y6DB 4Z6AL 3MDLA 3KQCL 2OYEP 2W2QE 1YO8A 2YGPA 1HCGB 3N8YB 1APQA 2BO2A 4XLWA 3NTBA 2WPME 2BQ7A 2NPRA 4COXA 5L2ZL 5CKMA 1XDTR 2WPJE 3C9AC 1NQLB 3HS7A 4O1ZA 3ELAL 1YUGA 2I9AA 2PHBB 3ASIA 3OLTA 2WPLE 2M74A 1C5MF 2GD4A 2W86A 3KQBL 1TLEA 1YGCL 3Q7DA 5KN5C 2BQWA 2OYUP 4ZAEB 2BOKL 2WYGB 2FLRL 1KSNB 1IQIL 1MQ5L 1XKAL 1PXXA 3U73A 2P93L 3M37L 4XBMA 3GISX 2FZZL 4M11A 2Y5HL 2XC4L 4NG9L 5E8DA 2W2ME 1G1SA 2P3FN 2B7DL 1F7EA 5JW1A 1DVAL 4JZEL 1UZPA 4A7IA 4MMXB 5CISA 1HREA 2VH0B 1P0SL 1HAEA 1APOA 3R05A 1IQLL 5JVZA 4BXSA 2BOHA 4X8UL 3NTGA 1NZIA 1LMJA 3ENSA 3TBDA 1EPJA 4X8SL 3KL6B 4ZXXL 1EBVA 2W3IB 1LK9A 4OTJA 2ADXA 3DEMA 4X8TL 4NA9L 3IITB 1SZBA 2P3FL 3KK6A 1KLJL 2Y81B 1G1RA 1L3YA 4Z0KB 1EGFA 2VVUL 1COUA 2VH6B 1M1XB 1WU1B 4YT6L 2VWNL 2BQ6A 2K2TA 3V64C 3TGFA 4M10A 1CCFA 1EMOA 2BOUA 2XBWL 4Z0LA 2P16L 1X7AL 1OB1C 1A3PA 1EAIC 2RA0L 2JJLA
chains in the Genus database with same CATH topology
1IOXA 5IKRA 2KNIA 1EMNA 2BOXA 4X8VL 1CVWL 3KCGL 4CSYA 2J95B 1K36A 1XKBA 3QCWA 2H9EL 3LTGD 2PR3B 2FLGA 2XC5L 1DX5I 2G00L 4YT7L 1EPGA 2MGPA 3S6XA 4BTIA 1PTHA 4RUTA 1Z6EL 2P3TA 3N8VA 1IJQA 1TPGA 3KQDL 1P9JA 4A94C 4BDXA 2WZPP 1IQNL 3CENL 5F1AA 1G2LB 2YGQA 3LC3B 2WFXB 2Y7XB 3SOBB 5IKTA 3LC5B 4RRXA 1ATDA 4ISIL 1ATEA 3K9XA 4D0EA 3Q3KB 2UWOB 2XBVL 1WHFA 3QMOA 1FFMA 4E1GA 2UWLB 1WHEA 3SOVA 1Z6CA 6COXA 3CS7L 2Q1JB 2EI8B 2RHPA 1U67A 3FBYA 2VVCK 3HO5A 1G2MB 1LPKA 1JV2B 4JZDL 3FFGL 1FF7A 3CA7A 3LN1A 4AQTA 5JB8E 1EQHA 2PUQL 4RS0A 1HRFA 1IQFL 4RRYA 3KRKA 2YGOA 2H9EC 5CKQA 1DIYA 1F0SB 1EPIA 2JKHL 4CUDA 2DDUA 2VWOL 1NT0A 4Y7AB 2Y80B 1IQHL 1DQBA 2WPHE 2WFTA 2MHPA 1EPHA 1FSBA 5JB9E 2W2PE 2WPIE 4ISHL 2XBXL 3GCWE 4ZH8B 3LN0A 4RRZA 3NJPC 1UZKA 3TZIA 3OLUA 1FE2A 2TGFA 3N8WA 3M36L 3F6UL 1HZ8A 1V3XB 5EGMB 4TGFA 4BTUA 3IJEB 1ATBA 1YUFA 1K37A 2BZ6L 2WG3C 2XBYL 3BT1A 1IP0A 2WPKE 1IGZA 2UWPB 1UZJA 1B9WA 1L5GB 1I0UA 2W26B 3HO3A 5FDQA 2Y38A 2P3UA 4G1MB 3POYA 4LORA 1IQJL 3HO4A 4YZUB 4JZFL 5L30L 2P26A 1JBUL 1XFEA 1GK5A 1AUTL 2KB9A 2J38B 1LMMA 1PGEA 4Y79B 5F19A 3F1SB 3V65B 1F7MA 4LMFA 2W2OE 2W2NE 2KV4A 1HJ7A 2Y5GL 5JBAE 1KIGL 1UZQA 1KLIL 1EQGA 4D90A 2VVVL 3N8YA 5JVYA 1ZAQA 3QH0A 2MGRA 1PRHA 3U7UG 1U8CB 1MQ6L 1F0RB 3KQEL 1G1TA 1MOXC 1N7DA 3H5CB 3BT2A 1W8BL 2Y7ZB 3ZYJB 5JBCE 2F9BL 2J34B 1BF9A 1PFXL 3LTFB 4JYVL 1FAKL 3P5BL 1G1QA 1CQEA 1O5DL 1IVOC 1N1IA 3HS5A 1URKA 1IGXA 2AYLA 2Y82B 1NFWB 5K0HB 1LPZA 2VWLL 1DDXA 2J94B 4O02B 5KIRA 1YUKB 4Y76B 1KLOA 3SW2A 4BXWA 4Y71B 4ZXYL 3RR3A 4NGAL 2RNLA 5CKNA 1FJSL 1IQKL 4XL1A 4ZHAB 3HS6A 4OTYA 2VJ3A 3ZYGA 3LIWB 1LQDA 3N8ZA 3N8XA 1IQGL 2Y5FL 1EZQB 2XC0L 3NT1A 2BMGA 4MMZB 2D1JB 2KL7A 2EI7B 2W3KB 2K2SB 3SOQA 4Y7BB 1CVUA 1IQEL 3BPSE 1NFUB 1HX2A 1ATAA 3TH3L 2VWMK 2P28B 5L2YL 1CCVA 3ZYIB 4JYUL 2FD6A 4BTTA 3N8WB 4MMYB 2WYJB 1Q4GA 2CJIB 3FCSB 3CFWA 5I46L 5JBBE 2FLBL 4CUFA 3PGHA 1QFKL 2EI6B 4RRWA 3TK5B 1HAFA 3TK6B 1IOEL 1HT5A 4D0FA 1ADXA 3LAQA 5IKQA 3GCXE 1NFYB 4FM5A 1IQML 5IKVA 1FAXL 1W7XL 1TOZA 2P94L 2J2UB 1J9CL 1HT8A 2J4IB 1CEJA 1NFXB 5COXA 1JL9A 4C16A 1CX2A 3HPTA 3MQEA 2I9BA 1LPGA 1RFNB 2WG4B 4BDWA 4PH9A 2P95L 3EGFA 1NPEB 4CUEA 4Y6DB 4Z6AL 3MDLA 3KQCL 2OYEP 2W2QE 1YO8A 2YGPA 1HCGB 3N8YB 1APQA 2BO2A 4XLWA 3NTBA 2WPME 2BQ7A 2NPRA 4COXA 5L2ZL 5CKMA 1XDTR 2WPJE 3C9AC 1NQLB 3HS7A 4O1ZA 3ELAL 1YUGA 2I9AA 2PHBB 3ASIA 3OLTA 2WPLE 2M74A 1C5MF 2GD4A 2W86A 3KQBL 1TLEA 1YGCL 3Q7DA 5KN5C 2BQWA 2OYUP 4ZAEB 2BOKL 2WYGB 2FLRL 1KSNB 1IQIL 1MQ5L 1XKAL 1PXXA 3U73A 2P93L 3M37L 4XBMA 3GISX 2FZZL 4M11A 2Y5HL 2XC4L 4NG9L 5E8DA 2W2ME 1G1SA 2P3FN 2B7DL 1F7EA 5JW1A 1DVAL 4JZEL 1UZPA 4A7IA 4MMXB 5CISA 1HREA 2VH0B 1P0SL 1HAEA 1APOA 3R05A 1IQLL 5JVZA 4BXSA 2BOHA 4X8UL 3NTGA 1NZIA 1LMJA 3ENSA 3TBDA 1EPJA 4X8SL 3KL6B 4ZXXL 1EBVA 2W3IB 4OTJA 2ADXA 3DEMA 4X8TL 4NA9L 3IITB 1SZBA 2P3FL 3KK6A 1KLJL 2Y81B 1G1RA 1L3YA 4Z0KB 1EGFA 2VVUL 1COUA 2VH6B 1M1XB 1WU1B 4YT6L 2VWNL 2BQ6A 2K2TA 3V64C 3TGFA 4M10A 1CCFA 1EMOA 2BOUA 2XBWL 4Z0LA 2P16L 1X7AL 1OB1C 1A3PA 1EAIC 2RA0L
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1IOX A;  5IKR A;  1EMN A;  2BOX A;  4X8V L;  1CVW L;  3KCG L;  4CSY A;  2J95 B;  1K36 A;  1XKB A;  3QCW A;  2H9E L;  3LTG D;  2PR3 B;  2FLG A;  2XC5 L;  1DX5 I;  2G00 L;  4YT7 L;  1EPG A;  2MGP A;  4BTI A;  1PTH A;  4RUT A;  1Z6E L;  2P3T A;  3N8V A;  1IJQ A;  1TPG A;  3KQD L;  1P9J A;  4BDX A;  1IQN L;  3CEN L;  5F1A A;  1G2L B;  3LC3 B;  2WFX B;  2Y7X B;  3SOB B;  5IKT A;  3LC5 B;  4RRX A;  1ATD A;  4ISI L;  1ATE A;  3K9X A;  4D0E A;  3Q3K B;  2UWO B;  2XBV L;  1WHF A;  3QMO A;  1FFM A;  4E1G A;  2UWL B;  1WHE A;  3SOV A;  1Z6C A;  6COX A;  3CS7 L;  2Q1J B;  2EI8 B;  2RHP A;  1U67 A;  3FBY A;  2VVC K;  3HO5 A;  1G2M B;  1LPK A;  1JV2 B;  4JZD L;  3FFG L;  1FF7 A;  3CA7 A;  3LN1 A;  4AQT A;  5JB8 E;  1EQH A;  2PUQ L;  4RS0 A;  1HRF A;  1IQF L;  4RRY A;  3KRK A;  2YGO A;  5CKQ A;  1DIY A;  1F0S B;  1EPI A;  2JKH L;  4CUD A;  2DDU A;  2VWO L;  1NT0 A;  4Y7A B;  2Y80 B;  1IQH L;  1DQB A;  2WPH E;  2WFT A;  2MHP A;  1EPH A;  1FSB A;  5JB9 E;  2W2P E;  2WPI E;  4ISH L;  2XBX L;  3GCW E;  4ZH8 B;  3LN0 A;  4RRZ A;  3NJP C;  1UZK A;  3TZI A;  3OLU A;  1FE2 A;  2TGF A;  3N8W A;  3M36 L;  3F6U L;  1HZ8 A;  1V3X B;  5EGM B;  4TGF A;  4BTU A;  3IJE B;  1ATB A;  1YUF A;  1K37 A;  2BZ6 L;  2WG3 C;  2XBY L;  3BT1 A;  1IP0 A;  2WPK E;  1IGZ A;  2UWP B;  1UZJ A;  1B9W A;  1L5G B;  1I0U A;  2W26 B;  3HO3 A;  5FDQ A;  2Y38 A;  2P3U A;  4G1M B;  3POY A;  4LOR A;  1IQJ L;  3HO4 A;  4YZU B;  4JZF L;  5L30 L;  2P26 A;  1JBU L;  1XFE A;  1GK5 A;  1AUT L;  2KB9 A;  2J38 B;  1PGE A;  4Y79 B;  5F19 A;  3F1S B;  3V65 B;  1F7M A;  4LMF A;  2W2O E;  2W2N E;  2KV4 A;  1HJ7 A;  2Y5G L;  5JBA E;  1KIG L;  1UZQ A;  1KLI L;  1EQG A;  4D90 A;  2VVV L;  3N8Y A;  5JVY A;  1ZAQ A;  3QH0 A;  2MGR A;  1PRH A;  3U7U G;  1U8C B;  1MQ6 L;  1F0R B;  3KQE L;  1G1T A;  1MOX C;  1N7D A;  3H5C B;  3BT2 A;  1W8B L;  2Y7Z B;  3ZYJ B;  5JBC E;  2F9B L;  2J34 B;  1BF9 A;  1PFX L;  3LTF B;  4JYV L;  1FAK L;  3P5B L;  1G1Q A;  1CQE A;  1O5D L;  1IVO C;  1N1I A;  3HS5 A;  1URK A;  1IGX A;  2AYL A;  2Y82 B;  1NFW B;  5K0H B;  1LPZ A;  2VWL L;  1DDX A;  2J94 B;  4O02 B;  5KIR A;  1YUK B;  4Y76 B;  1KLO A;  3SW2 A;  4BXW A;  4Y71 B;  4ZXY L;  3RR3 A;  4NGA L;  2RNL A;  5CKN A;  1FJS L;  1IQK L;  4XL1 A;  4ZHA B;  3HS6 A;  4OTY A;  2VJ3 A;  3ZYG A;  3LIW B;  1LQD A;  3N8Z A;  3N8X A;  1IQG L;  2Y5F L;  1EZQ B;  2XC0 L;  3NT1 A;  2BMG A;  4MMZ B;  2D1J B;  2KL7 A;  2EI7 B;  2W3K B;  2K2S B;  3SOQ A;  4Y7B B;  1CVU A;  1IQE L;  3BPS E;  1NFU B;  1HX2 A;  1ATA A;  3TH3 L;  2VWM K;  2P28 B;  5L2Y L;  1CCV A;  3ZYI B;  4JYU L;  2FD6 A;  4BTT A;  3N8W B;  4MMY B;  2WYJ B;  1Q4G A;  2CJI B;  3FCS B;  3CFW A;  5I46 L;  5JBB E;  2FLB L;  4CUF A;  3PGH A;  1QFK L;  2EI6 B;  4RRW A;  3TK5 B;  1HAF A;  3TK6 B;  1IOE L;  1HT5 A;  4D0F A;  1ADX A;  3LAQ A;  5IKQ A;  3GCX E;  1NFY B;  4FM5 A;  1IQM L;  5IKV A;  1FAX L;  1W7X L;  1TOZ A;  2P94 L;  2J2U B;  1J9C L;  1HT8 A;  2J4I B;  1CEJ A;  1NFX B;  5COX A;  1JL9 A;  4C16 A;  1CX2 A;  3HPT A;  3MQE A;  2I9B A;  1LPG A;  1RFN B;  2WG4 B;  4BDW A;  4PH9 A;  2P95 L;  3EGF A;  1NPE B;  4CUE A;  4Y6D B;  4Z6A L;  3MDL A;  3KQC L;  2OYE P;  2W2Q E;  1YO8 A;  2YGP A;  1HCG B;  3N8Y B;  1APQ A;  2BO2 A;  4XLW A;  3NTB A;  2WPM E;  2BQ7 A;  2NPR A;  4COX A;  5L2Z L;  5CKM A;  1XDT R;  2WPJ E;  3C9A C;  1NQL B;  3HS7 A;  4O1Z A;  3ELA L;  1YUG A;  2I9A A;  2PHB B;  3ASI A;  3OLT A;  2WPL E;  2M74 A;  1C5M F;  2GD4 A;  2W86 A;  3KQB L;  1TLE A;  1YGC L;  3Q7D A;  5KN5 C;  2BQW A;  2OYU P;  4ZAE B;  2BOK L;  2WYG B;  2FLR L;  1KSN B;  1IQI L;  1MQ5 L;  1XKA L;  1PXX A;  3U73 A;  2P93 L;  3M37 L;  4XBM A;  3GIS X;  2FZZ L;  4M11 A;  2Y5H L;  2XC4 L;  4NG9 L;  5E8D A;  2W2M E;  1G1S A;  2P3F N;  2B7D L;  1F7E A;  5JW1 A;  1DVA L;  4JZE L;  1UZP A;  4A7I A;  4MMX B;  5CIS A;  1HRE A;  2VH0 B;  1P0S L;  1HAE A;  1APO A;  3R05 A;  1IQL L;  5JVZ A;  4BXS A;  2BOH A;  4X8U L;  3NTG A;  1NZI A;  1LMJ A;  3ENS A;  3TBD A;  1EPJ A;  4X8S L;  3KL6 B;  4ZXX L;  1EBV A;  2W3I B;  4OTJ A;  2ADX A;  3DEM A;  4X8T L;  4NA9 L;  3IIT B;  1SZB A;  2P3F L;  3KK6 A;  1KLJ L;  2Y81 B;  1G1R A;  1L3Y A;  4Z0K B;  1EGF A;  2VVU L;  1COU A;  2VH6 B;  1M1X B;  1WU1 B;  4YT6 L;  2VWN L;  2BQ6 A;  2K2T A;  3V64 C;  3TGF A;  4M10 A;  1CCF A;  1EMO A;  2BOU A;  2XBW L;  4Z0L A;  2P16 L;  1X7A L;  1OB1 C;  1A3P A;  1EAI C;  2RA0 L; 
#chains in the Genus database with same CATH topology
 1IOX A;  5IKR A;  2KNI A;  1EMN A;  2BOX A;  4X8V L;  1CVW L;  3KCG L;  4CSY A;  2BT7 A;  2J95 B;  1K36 A;  1XKB A;  3QCW A;  2H9E L;  3LTG D;  2PR3 B;  2FLG A;  2XC5 L;  1DX5 I;  2G00 L;  4YT7 L;  1EPG A;  2MGP A;  3S6X A;  4BTI A;  1PTH A;  4RUT A;  1Z6E L;  2P3T A;  3N8V A;  1IJQ A;  1TPG A;  3KQD L;  1P9J A;  4A94 C;  4BDX A;  2WZP P;  1IQN L;  3CEN L;  5F1A A;  1G2L B;  2YGQ A;  1QIU A;  3LC3 B;  2WFX B;  2Y7X B;  3SOB B;  5IKT A;  4GU4 A;  3LC5 B;  4RRX A;  1ATD A;  4ISI L;  1ATE A;  3K9X A;  4D0E A;  3Q3K B;  2UWO B;  2BSF A;  2XBV L;  1WHF A;  3QMO A;  1FFM A;  4E1G A;  2UWL B;  1WHE A;  3SOV A;  1Z6C A;  6COX A;  3CS7 L;  2Q1J B;  2EI8 B;  2RHP A;  1U67 A;  3FBY A;  2VVC K;  3HO5 A;  1G2M B;  1LPK A;  1JV2 B;  4JZD L;  3FFG L;  1FF7 A;  3CA7 A;  3LN1 A;  4AQT A;  5JB8 E;  1EQH A;  2PUQ L;  4RS0 A;  1HRF A;  1IQF L;  4RRY A;  3KRK A;  2YGO A;  2H9E C;  5CKQ A;  1DIY A;  1F0S B;  1EPI A;  2JKH L;  4CUD A;  2DDU A;  2VWO L;  1NT0 A;  4Y7A B;  2Y80 B;  1IQH L;  1DQB A;  2WPH E;  2WFT A;  2MHP A;  1EPH A;  1FSB A;  5JB9 E;  2W2P E;  2WPI E;  4ISH L;  2XBX L;  3GCW E;  4ZH8 B;  3LN0 A;  4RRZ A;  3NJP C;  1UZK A;  3TZI A;  3OLU A;  1FE2 A;  2TGF A;  3N8W A;  3M36 L;  3F6U L;  1HZ8 A;  1V3X B;  5EGM B;  4TGF A;  4BTU A;  3IJE B;  1ATB A;  1YUF A;  1K37 A;  2BZ6 L;  2WG3 C;  2XBY L;  3BT1 A;  1IP0 A;  2WPK E;  1IGZ A;  2UWP B;  1UZJ A;  1B9W A;  1L5G B;  1I0U A;  2W26 B;  3HO3 A;  5FDQ A;  2Y38 A;  2P3U A;  4G1M B;  3POY A;  4LOR A;  1IQJ L;  3HO4 A;  4YZU B;  4JZF L;  5L30 L;  2P26 A;  1JBU L;  1XFE A;  1GK5 A;  1AUT L;  2KB9 A;  2J38 B;  1LMM A;  1PGE A;  4Y79 B;  5F19 A;  3F1S B;  3V65 B;  1F7M A;  4LMF A;  2W2O E;  2W2N E;  2KV4 A;  1HJ7 A;  2Y5G L;  5JBA E;  1KIG L;  1UZQ A;  1KLI L;  1EQG A;  4D90 A;  2VVV L;  3N8Y A;  5JVY A;  1ZAQ A;  3QH0 A;  2MGR A;  1PRH A;  3U7U G;  1U8C B;  1MQ6 L;  1F0R B;  3KQE L;  1G1T A;  1MOX C;  1N7D A;  3H5C B;  3BT2 A;  1W8B L;  2Y7Z B;  3ZYJ B;  5JBC E;  2F9B L;  2J34 B;  1BF9 A;  1PFX L;  3LTF B;  4JYV L;  1FAK L;  3P5B L;  1G1Q A;  1CQE A;  1O5D L;  1IVO C;  1N1I A;  2BT8 A;  3HS5 A;  1URK A;  1IGX A;  2AYL A;  2Y82 B;  1V1I A;  1NFW B;  5K0H B;  1LPZ A;  2VWL L;  1DDX A;  2J94 B;  2HOX A;  4GU3 A;  4O02 B;  5KIR A;  1YUK B;  4Y76 B;  1KLO A;  3SW2 A;  4BXW A;  4Y71 B;  4ZXY L;  3RR3 A;  4NGA L;  2RNL A;  5CKN A;  1FJS L;  1IQK L;  4XL1 A;  4ZHA B;  3HS6 A;  4OTY A;  2VJ3 A;  3ZYG A;  3LIW B;  1LQD A;  3N8Z A;  3N8X A;  1IQG L;  2Y5F L;  1EZQ B;  2XC0 L;  3NT1 A;  2BMG A;  4MMZ B;  2D1J B;  2KL7 A;  2EI7 B;  2W3K B;  2K2S B;  3SOQ A;  4Y7B B;  1CVU A;  1IQE L;  3BPS E;  2HOR A;  1NFU B;  1HX2 A;  1ATA A;  3TH3 L;  2VWM K;  2P28 B;  5L2Y L;  1CCV A;  1KKE A;  3ZYI B;  4JYU L;  2FD6 A;  4BTT A;  3N8W B;  4MMY B;  2WYJ B;  1Q4G A;  2CJI B;  3FCS B;  3CFW A;  5I46 L;  5JBB E;  2FLB L;  4CUF A;  3PGH A;  1QFK L;  2EI6 B;  4RRW A;  3TK5 B;  1HAF A;  1V1H A;  3TK6 B;  1IOE L;  1HT5 A;  4D0F A;  1ADX A;  3LAQ A;  5IKQ A;  3GCX E;  1NFY B;  4FM5 A;  1IQM L;  5IKV A;  1FAX L;  1W7X L;  1TOZ A;  2P94 L;  2J2U B;  1J9C L;  1HT8 A;  2J4I B;  1CEJ A;  1NFX B;  5COX A;  1JL9 A;  4C16 A;  1CX2 A;  3HPT A;  3MQE A;  2I9B A;  1LPG A;  2VRS A;  1RFN B;  2WG4 B;  4BDW A;  4PH9 A;  2P95 L;  3EGF A;  1NPE B;  4CUE A;  4Y6D B;  4Z6A L;  3MDL A;  3KQC L;  2OYE P;  2W2Q E;  1YO8 A;  2YGP A;  1HCG B;  3N8Y B;  1APQ A;  2BO2 A;  4XLW A;  3NTB A;  2WPM E;  2BQ7 A;  2NPR A;  4COX A;  5L2Z L;  5CKM A;  1XDT R;  2WPJ E;  3C9A C;  1NQL B;  3HS7 A;  4O1Z A;  3ELA L;  1YUG A;  2I9A A;  2PHB B;  3ASI A;  3OLT A;  2WPL E;  2M74 A;  1C5M F;  2GD4 A;  2W86 A;  3KQB L;  1TLE A;  1YGC L;  3Q7D A;  5KN5 C;  2BQW A;  2OYU P;  4ZAE B;  2BOK L;  2WYG B;  2FLR L;  1KSN B;  1IQI L;  1MQ5 L;  1XKA L;  1PXX A;  3U73 A;  2P93 L;  3M37 L;  4XBM A;  3GIS X;  2FZZ L;  4M11 A;  2Y5H L;  2XC4 L;  4NG9 L;  5E8D A;  2W2M E;  1G1S A;  2P3F N;  2B7D L;  1F7E A;  5JW1 A;  1DVA L;  4JZE L;  1UZP A;  4A7I A;  4MMX B;  5CIS A;  1HRE A;  2VH0 B;  1P0S L;  1HAE A;  1APO A;  3R05 A;  1IQL L;  5JVZ A;  4BXS A;  2BOH A;  4X8U L;  3NTG A;  1NZI A;  1LMJ A;  3ENS A;  3TBD A;  1EPJ A;  4X8S L;  3KL6 B;  4ZXX L;  1EBV A;  2W3I B;  1LK9 A;  4OTJ A;  2ADX A;  3DEM A;  4X8T L;  4NA9 L;  3IIT B;  1SZB A;  2P3F L;  3KK6 A;  1KLJ L;  2Y81 B;  1G1R A;  1L3Y A;  4Z0K B;  1EGF A;  2VVU L;  1COU A;  2VH6 B;  1M1X B;  1WU1 B;  4YT6 L;  2VWN L;  2BQ6 A;  2K2T A;  3V64 C;  3TGF A;  4M10 A;  1CCF A;  1EMO A;  2BOU A;  2XBW L;  4Z0L A;  2P16 L;  1X7A L;  1OB1 C;  1A3P A;  1EAI C;  2RA0 L;  2JJL A; 
#chains in the Genus database with same CATH homology
 1IOX A;  5IKR A;  2KNI A;  1EMN A;  2BOX A;  4X8V L;  1CVW L;  3KCG L;  4CSY A;  2J95 B;  1K36 A;  1XKB A;  3QCW A;  2H9E L;  3LTG D;  2PR3 B;  2FLG A;  2XC5 L;  1DX5 I;  2G00 L;  4YT7 L;  1EPG A;  2MGP A;  3S6X A;  4BTI A;  1PTH A;  4RUT A;  1Z6E L;  2P3T A;  3N8V A;  1IJQ A;  1TPG A;  3KQD L;  1P9J A;  4A94 C;  4BDX A;  2WZP P;  1IQN L;  3CEN L;  5F1A A;  1G2L B;  2YGQ A;  3LC3 B;  2WFX B;  2Y7X B;  3SOB B;  5IKT A;  3LC5 B;  4RRX A;  1ATD A;  4ISI L;  1ATE A;  3K9X A;  4D0E A;  3Q3K B;  2UWO B;  2XBV L;  1WHF A;  3QMO A;  1FFM A;  4E1G A;  2UWL B;  1WHE A;  3SOV A;  1Z6C A;  6COX A;  3CS7 L;  2Q1J B;  2EI8 B;  2RHP A;  1U67 A;  3FBY A;  2VVC K;  3HO5 A;  1G2M B;  1LPK A;  1JV2 B;  4JZD L;  3FFG L;  1FF7 A;  3CA7 A;  3LN1 A;  4AQT A;  5JB8 E;  1EQH A;  2PUQ L;  4RS0 A;  1HRF A;  1IQF L;  4RRY A;  3KRK A;  2YGO A;  2H9E C;  5CKQ A;  1DIY A;  1F0S B;  1EPI A;  2JKH L;  4CUD A;  2DDU A;  2VWO L;  1NT0 A;  4Y7A B;  2Y80 B;  1IQH L;  1DQB A;  2WPH E;  2WFT A;  2MHP A;  1EPH A;  1FSB A;  5JB9 E;  2W2P E;  2WPI E;  4ISH L;  2XBX L;  3GCW E;  4ZH8 B;  3LN0 A;  4RRZ A;  3NJP C;  1UZK A;  3TZI A;  3OLU A;  1FE2 A;  2TGF A;  3N8W A;  3M36 L;  3F6U L;  1HZ8 A;  1V3X B;  5EGM B;  4TGF A;  4BTU A;  3IJE B;  1ATB A;  1YUF A;  1K37 A;  2BZ6 L;  2WG3 C;  2XBY L;  3BT1 A;  1IP0 A;  2WPK E;  1IGZ A;  2UWP B;  1UZJ A;  1B9W A;  1L5G B;  1I0U A;  2W26 B;  3HO3 A;  5FDQ A;  2Y38 A;  2P3U A;  4G1M B;  3POY A;  4LOR A;  1IQJ L;  3HO4 A;  4YZU B;  4JZF L;  5L30 L;  2P26 A;  1JBU L;  1XFE A;  1GK5 A;  1AUT L;  2KB9 A;  2J38 B;  1LMM A;  1PGE A;  4Y79 B;  5F19 A;  3F1S B;  3V65 B;  1F7M A;  4LMF A;  2W2O E;  2W2N E;  2KV4 A;  1HJ7 A;  2Y5G L;  5JBA E;  1KIG L;  1UZQ A;  1KLI L;  1EQG A;  4D90 A;  2VVV L;  3N8Y A;  5JVY A;  1ZAQ A;  3QH0 A;  2MGR A;  1PRH A;  3U7U G;  1U8C B;  1MQ6 L;  1F0R B;  3KQE L;  1G1T A;  1MOX C;  1N7D A;  3H5C B;  3BT2 A;  1W8B L;  2Y7Z B;  3ZYJ B;  5JBC E;  2F9B L;  2J34 B;  1BF9 A;  1PFX L;  3LTF B;  4JYV L;  1FAK L;  3P5B L;  1G1Q A;  1CQE A;  1O5D L;  1IVO C;  1N1I A;  3HS5 A;  1URK A;  1IGX A;  2AYL A;  2Y82 B;  1NFW B;  5K0H B;  1LPZ A;  2VWL L;  1DDX A;  2J94 B;  4O02 B;  5KIR A;  1YUK B;  4Y76 B;  1KLO A;  3SW2 A;  4BXW A;  4Y71 B;  4ZXY L;  3RR3 A;  4NGA L;  2RNL A;  5CKN A;  1FJS L;  1IQK L;  4XL1 A;  4ZHA B;  3HS6 A;  4OTY A;  2VJ3 A;  3ZYG A;  3LIW B;  1LQD A;  3N8Z A;  3N8X A;  1IQG L;  2Y5F L;  1EZQ B;  2XC0 L;  3NT1 A;  2BMG A;  4MMZ B;  2D1J B;  2KL7 A;  2EI7 B;  2W3K B;  2K2S B;  3SOQ A;  4Y7B B;  1CVU A;  1IQE L;  3BPS E;  1NFU B;  1HX2 A;  1ATA A;  3TH3 L;  2VWM K;  2P28 B;  5L2Y L;  1CCV A;  3ZYI B;  4JYU L;  2FD6 A;  4BTT A;  3N8W B;  4MMY B;  2WYJ B;  1Q4G A;  2CJI B;  3FCS B;  3CFW A;  5I46 L;  5JBB E;  2FLB L;  4CUF A;  3PGH A;  1QFK L;  2EI6 B;  4RRW A;  3TK5 B;  1HAF A;  3TK6 B;  1IOE L;  1HT5 A;  4D0F A;  1ADX A;  3LAQ A;  5IKQ A;  3GCX E;  1NFY B;  4FM5 A;  1IQM L;  5IKV A;  1FAX L;  1W7X L;  1TOZ A;  2P94 L;  2J2U B;  1J9C L;  1HT8 A;  2J4I B;  1CEJ A;  1NFX B;  5COX A;  1JL9 A;  4C16 A;  1CX2 A;  3HPT A;  3MQE A;  2I9B A;  1LPG A;  1RFN B;  2WG4 B;  4BDW A;  4PH9 A;  2P95 L;  3EGF A;  1NPE B;  4CUE A;  4Y6D B;  4Z6A L;  3MDL A;  3KQC L;  2OYE P;  2W2Q E;  1YO8 A;  2YGP A;  1HCG B;  3N8Y B;  1APQ A;  2BO2 A;  4XLW A;  3NTB A;  2WPM E;  2BQ7 A;  2NPR A;  4COX A;  5L2Z L;  5CKM A;  1XDT R;  2WPJ E;  3C9A C;  1NQL B;  3HS7 A;  4O1Z A;  3ELA L;  1YUG A;  2I9A A;  2PHB B;  3ASI A;  3OLT A;  2WPL E;  2M74 A;  1C5M F;  2GD4 A;  2W86 A;  3KQB L;  1TLE A;  1YGC L;  3Q7D A;  5KN5 C;  2BQW A;  2OYU P;  4ZAE B;  2BOK L;  2WYG B;  2FLR L;  1KSN B;  1IQI L;  1MQ5 L;  1XKA L;  1PXX A;  3U73 A;  2P93 L;  3M37 L;  4XBM A;  3GIS X;  2FZZ L;  4M11 A;  2Y5H L;  2XC4 L;  4NG9 L;  5E8D A;  2W2M E;  1G1S A;  2P3F N;  2B7D L;  1F7E A;  5JW1 A;  1DVA L;  4JZE L;  1UZP A;  4A7I A;  4MMX B;  5CIS A;  1HRE A;  2VH0 B;  1P0S L;  1HAE A;  1APO A;  3R05 A;  1IQL L;  5JVZ A;  4BXS A;  2BOH A;  4X8U L;  3NTG A;  1NZI A;  1LMJ A;  3ENS A;  3TBD A;  1EPJ A;  4X8S L;  3KL6 B;  4ZXX L;  1EBV A;  2W3I B;  4OTJ A;  2ADX A;  3DEM A;  4X8T L;  4NA9 L;  3IIT B;  1SZB A;  2P3F L;  3KK6 A;  1KLJ L;  2Y81 B;  1G1R A;  1L3Y A;  4Z0K B;  1EGF A;  2VVU L;  1COU A;  2VH6 B;  1M1X B;  1WU1 B;  4YT6 L;  2VWN L;  2BQ6 A;  2K2T A;  3V64 C;  3TGF A;  4M10 A;  1CCF A;  1EMO A;  2BOU A;  2XBW L;  4Z0L A;  2P16 L;  1X7A L;  1OB1 C;  1A3P A;  1EAI C;  2RA0 L; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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