2P16L

Factor xa in complex with the inhibitor apixaban (bms-562247) aka 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxo-1-piperidinyl)phenyl)-4,5,6,7-tetrahydro-1h-pyrazolo[3, 4-c]pyridine-3-carboxamide
Total Genus 13
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
13
sequence length
52
structure length
52
Chain Sequence
KLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLE
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Discovery of 1-(4-Methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro- 1H-pyrazolo[3,4-c]pyridine-3-carboxamide (Apixaban, BMS-562247), a Highly Potent, Selective, Efficacious, and Orally Bioavailable Inhibitor of Blood Coagulation Factor Xa.
pubmed doi rcsb
molecule tags Hydrolase
molecule keywords Coagulation factor X (EC 3.4.21.6) (Stuart factor) (Stuart-P
total genus 13
structure length 52
sequence length 52
ec nomenclature ec 3.4.21.6: Coagulation factor Xa.
pdb deposition date 2007-03-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
L PF14670 FXa_inhibition Coagulation Factor Xa inhibitory site
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.25.10 Mainly Beta Ribbon Laminin Laminin 2p16L00
3Q7DA 1A3PA 5K0HB 5E8DA 1LQDA 1FJSL 1Z6CA 3H5CB 1ATEA 1HAEA 3MDLA 1TLEA 1HAFA 4XL1A 1K37A 2P3TA 2P3FL 4ZH8B 2PUQL 2VJ3A 3FFGL 2P3UA 5JVYA 4A7IA 3ZYIB 1FE2A 2TGFA 1EQGA 4FM5A 2P26A 1HRFA 1NFUB 5IKRA 1G1TA 4X8TL 4NG9L 2BZ6L 1FSBA 1DDXA 3V65B 2XC5L 3KCGL 5CISA 1DIYA 1IQFL 2Q1JB 1PXXA 2BO2A 1B9WA 2XC4L 1ATBA 2WPLE 4X8VL 1F7EA 1EQHA 1F7MA 1SZBA 4RRXA 1CCFA 4ZXXL 1KSNB 1LPKA 4Y79B 2OYEP 3BT2A 1K36A 5L2ZL 1BF9A 2H9EL 2VWLL 3R05A 1IQIL 2VWMK 2W2NE 1C5MF 1PGEA 2Y5FL 2WG4B 2I9BA 2RHPA 3HO3A 5CKMA 2VWNL 1G2LB 4CUFA 5COXA 2P3FN 2KL7A 4E1GA 4NA9L 4CUDA 3F6UL 1O5DL 3N8WA 1EMNA 2KB9A 1IQGL 3U7UG 2XBXL 2Y38A 2BQWA 4TGFA 3C9AC 4COXA 4D0FA 1FFMA 4XLWA 1U8CB 5IKTA 1KLOA 1OB1C 4YT6L 1AUTL 2VH6B 3ZYGA 1YO8A 1WHFA 2W2ME 2VVUL 4MMXB 1CCVA 1NFYB 3M36L 4LORA 4ZHAB 3QH0A 2Y80B 1GK5A 2Y5HL 2BQ6A 3GCXE 3RR3A 1NT0A 2I9AA 1JV2B 2BOXA 4YZUB 2ADXA 2WG3C 1COUA 1YUFA 3POYA 3GCWE 4AQTA 3N8VA 1Q4GA 1NPEB 3FBYA 3M37L 2BOHA 4X8UL 1IJQA 3HS5A 3OLTA 4RS0A 3BPSE 2AYLA 1JL9A 1RFNB 1YUGA 2P95L 4BDXA 4Y76B 4Z6AL 1HT5A 2W26B 4JZFL 4BXWA 3LTFB 1DVAL 1WHEA 5I46L 3GISX 4Z0LA 3N8YB 2FZZL 3P5BL 4OTYA 1XFEA 3K9XA 3LTGD 2J94B 3DEMA 1J9CL 4BXSA 1NZIA 2UWLB 1NFWB 1KIGL 2CJIB 2WPJE 5F1AA 1I0UA 2W3KB 1W7XL 2FLBL 2P16L 4M11A 3SOVA 3TK6B 2J4IB 4BTTA 3ELAL 3KQCL 3HS6A 1LPZA 2UWPB 2WPIE 1FAXL 1EMOA 2Y7XB 1TPGA 2EI6B 2YGPA 1MQ5L 1UZQA 5JBCE 3TZIA 1XDTR 1DQBA 1MQ6L 2F9BL 3NT1A 2PHBB 4X8SL 3NTBA 1EBVA 3V64C 1HZ8A 2VVCK 4OTJA 1IOXA 1ADXA 5F19A 1ATDA 3QMOA 4ISIL 5KN5C 4PH9A 1IQKL 2VVVL 1IQJL 2VWOL 3PGHA 3KQDL 1IQLL 2K2TA 4JYUL 2NPRA 2BMGA 3HO5A 2WFXB 3ENSA 2D1JB 2DDUA 2WYJB 1CX2A 4Z0KB 1IQEL 4M10A 2VH0B 2W2QE 1JBUL 2MGPA 6COXA 3FCSB 2J38B 4RRYA 3KRKA 1F0RB 1QFKL 1U67A 1KLJL 5KIRA 1IP0A 2PR3B 2WPHE 1CVWL 1YUKB 1G1QA 2P28B 2FLRL 3LC3B 1FF7A 3LN1A 4G1MB 1UZPA 2B7DL 4RRWA 3CENL 1EPIA 2EI8B 5FDQA 1EGFA 4Y7AB 1G2MB 1W8BL 3BT1A 1IQML 2OYUP 4Y6DB 1PFXL 1CEJA 1IOEL 2UWOB 3TH3L 1IGZA 4RUTA 3LIWB 1EZQB 1N1IA 5IKQA 3IITB 1MOXC 1EAIC 2J2UB 2W2OE 4XBMA 1EPJA 4JZEL 1UZJA 2FLGA 2JKHL 5CKQA 1L5GB 3QCWA 2BOKL 3KQBL 1G1RA 5IKVA 4D90A 3KK6A 1HT8A 1M1XB 3Q3KB 2K2SB 4O02B 2XC0L 1LPGA 3N8WB 1NQLB 4JZDL 2YGOA 4ZXYL 1X7AL 1IGXA 5L30L 2XBWL 4MMYB 1ATAA 1URKA 2Y82B 4D0EA 4YT7L 5JB9E 1HJ7A 3LC5B 4C16A 4CSYA 3SW2A 1EPHA 3U73A 1L3YA 5JB8E 1ZAQA 1WU1B 1XKBA 4O1ZA 1EPGA 1PTHA 1V3XB 2MHPA 2RA0L 1FAKL 3HS7A 3CA7A 3MQEA 3TK5B 2RNLA 1NFXB 4BDWA 3CS7L 1HREA 2M74A 4Y7BB 3TGFA 4BTUA 1IVOC 4MMZB 2XBVL 4Y71B 2KV4A 1P9JA 2P94L 1TOZA 4CUEA 3HPTA 1APQA 3SOBB 4BTIA 1YGCL 1KLIL 5JW1A 2P93L 2BOUA 5CKNA 3KL6B 3LAQA 3TBDA 5JVZA 1DX5I 3SOQA 3N8YA 2BQ7A 3ASIA 1CVUA 3HO4A 1IQNL 1PRHA 2WYGB 5L2YL 3ZYJB 3NJPC 2G00L 5JBBE 3CFWA 1UZKA 2Y5GL 2W3IB 5EGMB 1Z6EL 2EI7B 3F1SB 2Y7ZB 3N8XA 1N7DA 2WFTA 2Y81B 1P0SL 4NGAL 1XKAL 2GD4A 3EGFA 2MGRA 2WPKE 5JBAE 1HX2A 2W86A 2WPME 4JYVL 3NTGA 4ZAEB 3OLUA 1G1SA 3LN0A 4RRZA 2XBYL 3IJEB 3KQEL 1CQEA 2W2PE 1APOA 1IQHL 2J95B 4LMFA 3N8ZA 4ISHL 1HCGB 2J34B 2FD6A 1F0SB 1LMJA
chains in the Genus database with same CATH superfamily
3Q7DA 1A3PA 5K0HB 5E8DA 1LQDA 1FJSL 1Z6CA 3H5CB 1ATEA 1HAEA 3MDLA 1TLEA 1HAFA 4XL1A 1K37A 2P3TA 2P3FL 4ZH8B 2PUQL 2VJ3A 3FFGL 2P3UA 5JVYA 4A7IA 3ZYIB 1FE2A 2TGFA 1EQGA 4FM5A 2P26A 1HRFA 1NFUB 5IKRA 2BT8A 1G1TA 4X8TL 4NG9L 2BZ6L 1FSBA 1DDXA 3V65B 2XC5L 3KCGL 5CISA 4A94C 1DIYA 1IQFL 2Q1JB 1PXXA 2BO2A 1B9WA 2XC4L 1ATBA 2WPLE 4X8VL 1F7EA 1EQHA 1F7MA 1SZBA 4RRXA 1QIUA 1CCFA 4ZXXL 1KSNB 1LPKA 4Y79B 2OYEP 3BT2A 1K36A 5L2ZL 1BF9A 2H9EL 2VWLL 3R05A 1IQIL 2VWMK 2W2NE 1C5MF 1PGEA 2Y5FL 2WG4B 2I9BA 2RHPA 3HO3A 5CKMA 2VWNL 1G2LB 4CUFA 5COXA 2P3FN 2KL7A 4E1GA 4NA9L 4CUDA 3F6UL 1O5DL 3N8WA 1EMNA 2KB9A 1IQGL 3U7UG 2XBXL 2Y38A 2BQWA 4TGFA 3C9AC 4COXA 4D0FA 1FFMA 4XLWA 1U8CB 5IKTA 1KLOA 1OB1C 4YT6L 1AUTL 2VH6B 3ZYGA 1YO8A 1V1HA 1WHFA 2W2ME 2VVUL 4MMXB 1CCVA 1NFYB 3M36L 4LORA 4ZHAB 3QH0A 2Y80B 1GK5A 2Y5HL 2BQ6A 3GCXE 3RR3A 1NT0A 2I9AA 1JV2B 2BOXA 4YZUB 2ADXA 2WG3C 1COUA 1YUFA 3POYA 3GCWE 4AQTA 3N8VA 1Q4GA 1NPEB 3FBYA 3M37L 2BOHA 4X8UL 1IJQA 3HS5A 3OLTA 4RS0A 3BPSE 2AYLA 1JL9A 1RFNB 1YUGA 2P95L 4BDXA 4Y76B 4Z6AL 1HT5A 2W26B 4JZFL 4BXWA 3LTFB 1DVAL 1WHEA 2VRSA 5I46L 3GISX 4Z0LA 3N8YB 2FZZL 3P5BL 4OTYA 1XFEA 3K9XA 3LTGD 2WZPP 2J94B 3DEMA 1J9CL 4BXSA 1NZIA 2UWLB 1NFWB 2BT7A 1KIGL 2CJIB 2WPJE 5F1AA 1I0UA 2W3KB 1W7XL 2FLBL 2P16L 4M11A 3SOVA 3TK6B 2J4IB 4BTTA 3ELAL 3KQCL 3HS6A 1LPZA 2UWPB 2WPIE 1FAXL 1EMOA 2Y7XB 1TPGA 2EI6B 2YGPA 1MQ5L 1UZQA 5JBCE 3TZIA 1XDTR 1DQBA 1MQ6L 2F9BL 3NT1A 2PHBB 4X8SL 3NTBA 1EBVA 3V64C 2KNIA 1HZ8A 2VVCK 4OTJA 1IOXA 1ADXA 5F19A 1ATDA 3QMOA 4ISIL 5KN5C 4PH9A 1IQKL 2VVVL 1IQJL 2VWOL 3PGHA 3KQDL 4GU4A 1IQLL 2K2TA 4JYUL 2NPRA 2BMGA 3HO5A 2WFXB 3ENSA 2D1JB 2DDUA 2WYJB 1CX2A 4Z0KB 2HORA 1LMMA 1IQEL 4M10A 2VH0B 2W2QE 1JBUL 2MGPA 6COXA 3FCSB 2J38B 4RRYA 3KRKA 1F0RB 1QFKL 1U67A 1KLJL 5KIRA 2JJLA 1IP0A 2PR3B 2HOXA 2WPHE 1CVWL 2YGQA 1YUKB 1G1QA 2P28B 2FLRL 3LC3B 1FF7A 3LN1A 4G1MB 1UZPA 2B7DL 4RRWA 3CENL 1EPIA 2EI8B 5FDQA 1EGFA 4Y7AB 1G2MB 1W8BL 3BT1A 1IQML 2OYUP 4Y6DB 1PFXL 1CEJA 1IOEL 2UWOB 3TH3L 1IGZA 4RUTA 3LIWB 1EZQB 1N1IA 5IKQA 3IITB 1MOXC 1EAIC 2J2UB 2W2OE 4XBMA 1EPJA 4JZEL 1UZJA 2FLGA 2JKHL 5CKQA 1L5GB 3QCWA 2BOKL 3KQBL 1G1RA 5IKVA 4D90A 3KK6A 1HT8A 1M1XB 3Q3KB 2K2SB 3S6XA 4O02B 2XC0L 1LPGA 3N8WB 1NQLB 4JZDL 2YGOA 4ZXYL 1X7AL 1IGXA 5L30L 2XBWL 4MMYB 1ATAA 1URKA 2Y82B 4D0EA 4YT7L 5JB9E 2H9EC 1HJ7A 3LC5B 4C16A 4CSYA 3SW2A 1EPHA 3U73A 1L3YA 5JB8E 1ZAQA 1WU1B 1XKBA 4O1ZA 1EPGA 1PTHA 1V3XB 2MHPA 2RA0L 1FAKL 3HS7A 3CA7A 3MQEA 3TK5B 2RNLA 1NFXB 4BDWA 3CS7L 1HREA 2M74A 4Y7BB 3TGFA 2BSFA 4BTUA 1IVOC 4MMZB 2XBVL 4Y71B 2KV4A 1P9JA 2P94L 1TOZA 4CUEA 3HPTA 1APQA 3SOBB 4BTIA 1YGCL 1KLIL 5JW1A 2P93L 2BOUA 5CKNA 3KL6B 3LAQA 3TBDA 5JVZA 1DX5I 3SOQA 3N8YA 2BQ7A 3ASIA 1CVUA 3HO4A 1V1IA 1IQNL 1PRHA 2WYGB 5L2YL 3ZYJB 3NJPC 2G00L 5JBBE 3CFWA 1UZKA 2Y5GL 2W3IB 5EGMB 1Z6EL 2EI7B 3F1SB 2Y7ZB 3N8XA 1N7DA 2WFTA 1LK9A 2Y81B 1KKEA 1P0SL 4NGAL 1XKAL 2GD4A 3EGFA 2MGRA 2WPKE 5JBAE 1HX2A 2W86A 2WPME 4JYVL 3NTGA 4ZAEB 3OLUA 1G1SA 3LN0A 4RRZA 2XBYL 3IJEB 3KQEL 1CQEA 2W2PE 4GU3A 1APOA 1IQHL 2J95B 4LMFA 3N8ZA 4ISHL 1HCGB 2J34B 2FD6A 1F0SB 1LMJA
chains in the Genus database with same CATH topology
3Q7DA 1A3PA 5K0HB 5E8DA 1LQDA 1FJSL 1Z6CA 3H5CB 1ATEA 1HAEA 3MDLA 1TLEA 1HAFA 4XL1A 1K37A 2P3TA 2P3FL 4ZH8B 2PUQL 2VJ3A 3FFGL 2P3UA 5JVYA 4A7IA 3ZYIB 1FE2A 2TGFA 1EQGA 4FM5A 2P26A 1HRFA 1NFUB 5IKRA 1G1TA 4X8TL 4NG9L 2BZ6L 1FSBA 1DDXA 3V65B 2XC5L 3KCGL 5CISA 4A94C 1DIYA 1IQFL 2Q1JB 1PXXA 2BO2A 1B9WA 2XC4L 1ATBA 2WPLE 4X8VL 1F7EA 1EQHA 1F7MA 1SZBA 4RRXA 1CCFA 4ZXXL 1KSNB 1LPKA 4Y79B 2OYEP 3BT2A 1K36A 5L2ZL 1BF9A 2H9EL 2VWLL 3R05A 1IQIL 2VWMK 2W2NE 1C5MF 1PGEA 2Y5FL 2WG4B 2I9BA 2RHPA 3HO3A 5CKMA 2VWNL 1G2LB 4CUFA 5COXA 2P3FN 2KL7A 4E1GA 4NA9L 4CUDA 3F6UL 1O5DL 3N8WA 1EMNA 2KB9A 1IQGL 3U7UG 2XBXL 2Y38A 2BQWA 4TGFA 3C9AC 4COXA 4D0FA 1FFMA 4XLWA 1U8CB 5IKTA 1KLOA 1OB1C 4YT6L 1AUTL 2VH6B 3ZYGA 1YO8A 1WHFA 2W2ME 2VVUL 4MMXB 1CCVA 1NFYB 3M36L 4LORA 4ZHAB 3QH0A 2Y80B 1GK5A 2Y5HL 2BQ6A 3GCXE 3RR3A 1NT0A 2I9AA 1JV2B 2BOXA 4YZUB 2ADXA 2WG3C 1COUA 1YUFA 3POYA 3GCWE 4AQTA 3N8VA 1Q4GA 1NPEB 3FBYA 3M37L 2BOHA 4X8UL 1IJQA 3HS5A 3OLTA 4RS0A 3BPSE 2AYLA 1JL9A 1RFNB 1YUGA 2P95L 4BDXA 4Y76B 4Z6AL 1HT5A 2W26B 4JZFL 4BXWA 3LTFB 1DVAL 1WHEA 5I46L 3GISX 4Z0LA 3N8YB 2FZZL 3P5BL 4OTYA 1XFEA 3K9XA 3LTGD 2WZPP 2J94B 3DEMA 1J9CL 4BXSA 1NZIA 2UWLB 1NFWB 1KIGL 2CJIB 2WPJE 5F1AA 1I0UA 2W3KB 1W7XL 2FLBL 2P16L 4M11A 3SOVA 3TK6B 2J4IB 4BTTA 3ELAL 3KQCL 3HS6A 1LPZA 2UWPB 2WPIE 1FAXL 1EMOA 2Y7XB 1TPGA 2EI6B 2YGPA 1MQ5L 1UZQA 5JBCE 3TZIA 1XDTR 1DQBA 1MQ6L 2F9BL 3NT1A 2PHBB 4X8SL 3NTBA 1EBVA 3V64C 2KNIA 1HZ8A 2VVCK 4OTJA 1IOXA 1ADXA 5F19A 1ATDA 3QMOA 4ISIL 5KN5C 4PH9A 1IQKL 2VVVL 1IQJL 2VWOL 3PGHA 3KQDL 1IQLL 2K2TA 4JYUL 2NPRA 2BMGA 3HO5A 2WFXB 3ENSA 2D1JB 2DDUA 2WYJB 1CX2A 4Z0KB 1LMMA 1IQEL 4M10A 2VH0B 2W2QE 1JBUL 2MGPA 6COXA 3FCSB 2J38B 4RRYA 3KRKA 1F0RB 1QFKL 1U67A 1KLJL 5KIRA 1IP0A 2PR3B 2WPHE 1CVWL 2YGQA 1YUKB 1G1QA 2P28B 2FLRL 3LC3B 1FF7A 3LN1A 4G1MB 1UZPA 2B7DL 4RRWA 3CENL 1EPIA 2EI8B 5FDQA 1EGFA 4Y7AB 1G2MB 1W8BL 3BT1A 1IQML 2OYUP 4Y6DB 1PFXL 1CEJA 1IOEL 2UWOB 3TH3L 1IGZA 4RUTA 3LIWB 1EZQB 1N1IA 5IKQA 3IITB 1MOXC 1EAIC 2J2UB 2W2OE 4XBMA 1EPJA 4JZEL 1UZJA 2FLGA 2JKHL 5CKQA 1L5GB 3QCWA 2BOKL 3KQBL 1G1RA 5IKVA 4D90A 3KK6A 1HT8A 1M1XB 3Q3KB 2K2SB 3S6XA 4O02B 2XC0L 1LPGA 3N8WB 1NQLB 4JZDL 2YGOA 4ZXYL 1X7AL 1IGXA 5L30L 2XBWL 4MMYB 1ATAA 1URKA 2Y82B 4D0EA 4YT7L 5JB9E 2H9EC 1HJ7A 3LC5B 4C16A 4CSYA 3SW2A 1EPHA 3U73A 1L3YA 5JB8E 1ZAQA 1WU1B 1XKBA 4O1ZA 1EPGA 1PTHA 1V3XB 2MHPA 2RA0L 1FAKL 3HS7A 3CA7A 3MQEA 3TK5B 2RNLA 1NFXB 4BDWA 3CS7L 1HREA 2M74A 4Y7BB 3TGFA 4BTUA 1IVOC 4MMZB 2XBVL 4Y71B 2KV4A 1P9JA 2P94L 1TOZA 4CUEA 3HPTA 1APQA 3SOBB 4BTIA 1YGCL 1KLIL 5JW1A 2P93L 2BOUA 5CKNA 3KL6B 3LAQA 3TBDA 5JVZA 1DX5I 3SOQA 3N8YA 2BQ7A 3ASIA 1CVUA 3HO4A 1IQNL 1PRHA 2WYGB 5L2YL 3ZYJB 3NJPC 2G00L 5JBBE 3CFWA 1UZKA 2Y5GL 2W3IB 5EGMB 1Z6EL 2EI7B 3F1SB 2Y7ZB 3N8XA 1N7DA 2WFTA 2Y81B 1P0SL 4NGAL 1XKAL 2GD4A 3EGFA 2MGRA 2WPKE 5JBAE 1HX2A 2W86A 2WPME 4JYVL 3NTGA 4ZAEB 3OLUA 1G1SA 3LN0A 4RRZA 2XBYL 3IJEB 3KQEL 1CQEA 2W2PE 1APOA 1IQHL 2J95B 4LMFA 3N8ZA 4ISHL 1HCGB 2J34B 2FD6A 1F0SB 1LMJA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3Q7D A;  1A3P A;  5K0H B;  5E8D A;  1LQD A;  1FJS L;  1Z6C A;  3H5C B;  1ATE A;  1HAE A;  3MDL A;  1TLE A;  1HAF A;  4XL1 A;  1K37 A;  2P3T A;  2P3F L;  4ZH8 B;  2PUQ L;  2VJ3 A;  3FFG L;  2P3U A;  5JVY A;  4A7I A;  3ZYI B;  1FE2 A;  2TGF A;  1EQG A;  4FM5 A;  2P26 A;  1HRF A;  1NFU B;  5IKR A;  1G1T A;  4X8T L;  4NG9 L;  2BZ6 L;  1FSB A;  1DDX A;  3V65 B;  2XC5 L;  3KCG L;  5CIS A;  1DIY A;  1IQF L;  2Q1J B;  1PXX A;  2BO2 A;  1B9W A;  2XC4 L;  1ATB A;  2WPL E;  4X8V L;  1F7E A;  1EQH A;  1F7M A;  1SZB A;  4RRX A;  1CCF A;  4ZXX L;  1KSN B;  1LPK A;  4Y79 B;  2OYE P;  3BT2 A;  1K36 A;  5L2Z L;  1BF9 A;  2H9E L;  2VWL L;  3R05 A;  1IQI L;  2VWM K;  2W2N E;  1C5M F;  1PGE A;  2Y5F L;  2WG4 B;  2I9B A;  2RHP A;  3HO3 A;  5CKM A;  2VWN L;  1G2L B;  4CUF A;  5COX A;  2P3F N;  2KL7 A;  4E1G A;  4NA9 L;  4CUD A;  3F6U L;  1O5D L;  3N8W A;  1EMN A;  2KB9 A;  1IQG L;  3U7U G;  2XBX L;  2Y38 A;  2BQW A;  4TGF A;  3C9A C;  4COX A;  4D0F A;  1FFM A;  4XLW A;  1U8C B;  5IKT A;  1KLO A;  1OB1 C;  4YT6 L;  1AUT L;  2VH6 B;  3ZYG A;  1YO8 A;  1WHF A;  2W2M E;  2VVU L;  4MMX B;  1CCV A;  1NFY B;  3M36 L;  4LOR A;  4ZHA B;  3QH0 A;  2Y80 B;  1GK5 A;  2Y5H L;  2BQ6 A;  3GCX E;  3RR3 A;  1NT0 A;  2I9A A;  1JV2 B;  2BOX A;  4YZU B;  2ADX A;  2WG3 C;  1COU A;  1YUF A;  3POY A;  3GCW E;  4AQT A;  3N8V A;  1Q4G A;  1NPE B;  3FBY A;  3M37 L;  2BOH A;  4X8U L;  1IJQ A;  3HS5 A;  3OLT A;  4RS0 A;  3BPS E;  2AYL A;  1JL9 A;  1RFN B;  1YUG A;  2P95 L;  4BDX A;  4Y76 B;  4Z6A L;  1HT5 A;  2W26 B;  4JZF L;  4BXW A;  3LTF B;  1DVA L;  1WHE A;  5I46 L;  3GIS X;  4Z0L A;  3N8Y B;  2FZZ L;  3P5B L;  4OTY A;  1XFE A;  3K9X A;  3LTG D;  2J94 B;  3DEM A;  1J9C L;  4BXS A;  1NZI A;  2UWL B;  1NFW B;  1KIG L;  2CJI B;  2WPJ E;  5F1A A;  1I0U A;  2W3K B;  1W7X L;  2FLB L;  2P16 L;  4M11 A;  3SOV A;  3TK6 B;  2J4I B;  4BTT A;  3ELA L;  3KQC L;  3HS6 A;  1LPZ A;  2UWP B;  2WPI E;  1FAX L;  1EMO A;  2Y7X B;  1TPG A;  2EI6 B;  2YGP A;  1MQ5 L;  1UZQ A;  5JBC E;  3TZI A;  1XDT R;  1DQB A;  1MQ6 L;  2F9B L;  3NT1 A;  2PHB B;  4X8S L;  3NTB A;  1EBV A;  3V64 C;  1HZ8 A;  2VVC K;  4OTJ A;  1IOX A;  1ADX A;  5F19 A;  1ATD A;  3QMO A;  4ISI L;  5KN5 C;  4PH9 A;  1IQK L;  2VVV L;  1IQJ L;  2VWO L;  3PGH A;  3KQD L;  1IQL L;  2K2T A;  4JYU L;  2NPR A;  2BMG A;  3HO5 A;  2WFX B;  3ENS A;  2D1J B;  2DDU A;  2WYJ B;  1CX2 A;  4Z0K B;  1IQE L;  4M10 A;  2VH0 B;  2W2Q E;  1JBU L;  2MGP A;  6COX A;  3FCS B;  2J38 B;  4RRY A;  3KRK A;  1F0R B;  1QFK L;  1U67 A;  1KLJ L;  5KIR A;  1IP0 A;  2PR3 B;  2WPH E;  1CVW L;  1YUK B;  1G1Q A;  2P28 B;  2FLR L;  3LC3 B;  1FF7 A;  3LN1 A;  4G1M B;  1UZP A;  2B7D L;  4RRW A;  3CEN L;  1EPI A;  2EI8 B;  5FDQ A;  1EGF A;  4Y7A B;  1G2M B;  1W8B L;  3BT1 A;  1IQM L;  2OYU P;  4Y6D B;  1PFX L;  1CEJ A;  1IOE L;  2UWO B;  3TH3 L;  1IGZ A;  4RUT A;  3LIW B;  1EZQ B;  1N1I A;  5IKQ A;  3IIT B;  1MOX C;  1EAI C;  2J2U B;  2W2O E;  4XBM A;  1EPJ A;  4JZE L;  1UZJ A;  2FLG A;  2JKH L;  5CKQ A;  1L5G B;  3QCW A;  2BOK L;  3KQB L;  1G1R A;  5IKV A;  4D90 A;  3KK6 A;  1HT8 A;  1M1X B;  3Q3K B;  2K2S B;  4O02 B;  2XC0 L;  1LPG A;  3N8W B;  1NQL B;  4JZD L;  2YGO A;  4ZXY L;  1X7A L;  1IGX A;  5L30 L;  2XBW L;  4MMY B;  1ATA A;  1URK A;  2Y82 B;  4D0E A;  4YT7 L;  5JB9 E;  1HJ7 A;  3LC5 B;  4C16 A;  4CSY A;  3SW2 A;  1EPH A;  3U73 A;  1L3Y A;  5JB8 E;  1ZAQ A;  1WU1 B;  1XKB A;  4O1Z A;  1EPG A;  1PTH A;  1V3X B;  2MHP A;  2RA0 L;  1FAK L;  3HS7 A;  3CA7 A;  3MQE A;  3TK5 B;  2RNL A;  1NFX B;  4BDW A;  3CS7 L;  1HRE A;  2M74 A;  4Y7B B;  3TGF A;  4BTU A;  1IVO C;  4MMZ B;  2XBV L;  4Y71 B;  2KV4 A;  1P9J A;  2P94 L;  1TOZ A;  4CUE A;  3HPT A;  1APQ A;  3SOB B;  4BTI A;  1YGC L;  1KLI L;  5JW1 A;  2P93 L;  2BOU A;  5CKN A;  3KL6 B;  3LAQ A;  3TBD A;  5JVZ A;  1DX5 I;  3SOQ A;  3N8Y A;  2BQ7 A;  3ASI A;  1CVU A;  3HO4 A;  1IQN L;  1PRH A;  2WYG B;  5L2Y L;  3ZYJ B;  3NJP C;  2G00 L;  5JBB E;  3CFW A;  1UZK A;  2Y5G L;  2W3I B;  5EGM B;  1Z6E L;  2EI7 B;  3F1S B;  2Y7Z B;  3N8X A;  1N7D A;  2WFT A;  2Y81 B;  1P0S L;  4NGA L;  1XKA L;  2GD4 A;  3EGF A;  2MGR A;  2WPK E;  5JBA E;  1HX2 A;  2W86 A;  2WPM E;  4JYV L;  3NTG A;  4ZAE B;  3OLU A;  1G1S A;  3LN0 A;  4RRZ A;  2XBY L;  3IJE B;  3KQE L;  1CQE A;  2W2P E;  1APO A;  1IQH L;  2J95 B;  4LMF A;  3N8Z A;  4ISH L;  1HCG B;  2J34 B;  2FD6 A;  1F0S B;  1LMJ A; 
#chains in the Genus database with same CATH topology
 3Q7D A;  1A3P A;  5K0H B;  5E8D A;  1LQD A;  1FJS L;  1Z6C A;  3H5C B;  1ATE A;  1HAE A;  3MDL A;  1TLE A;  1HAF A;  4XL1 A;  1K37 A;  2P3T A;  2P3F L;  4ZH8 B;  2PUQ L;  2VJ3 A;  3FFG L;  2P3U A;  5JVY A;  4A7I A;  3ZYI B;  1FE2 A;  2TGF A;  1EQG A;  4FM5 A;  2P26 A;  1HRF A;  1NFU B;  5IKR A;  2BT8 A;  1G1T A;  4X8T L;  4NG9 L;  2BZ6 L;  1FSB A;  1DDX A;  3V65 B;  2XC5 L;  3KCG L;  5CIS A;  4A94 C;  1DIY A;  1IQF L;  2Q1J B;  1PXX A;  2BO2 A;  1B9W A;  2XC4 L;  1ATB A;  2WPL E;  4X8V L;  1F7E A;  1EQH A;  1F7M A;  1SZB A;  4RRX A;  1QIU A;  1CCF A;  4ZXX L;  1KSN B;  1LPK A;  4Y79 B;  2OYE P;  3BT2 A;  1K36 A;  5L2Z L;  1BF9 A;  2H9E L;  2VWL L;  3R05 A;  1IQI L;  2VWM K;  2W2N E;  1C5M F;  1PGE A;  2Y5F L;  2WG4 B;  2I9B A;  2RHP A;  3HO3 A;  5CKM A;  2VWN L;  1G2L B;  4CUF A;  5COX A;  2P3F N;  2KL7 A;  4E1G A;  4NA9 L;  4CUD A;  3F6U L;  1O5D L;  3N8W A;  1EMN A;  2KB9 A;  1IQG L;  3U7U G;  2XBX L;  2Y38 A;  2BQW A;  4TGF A;  3C9A C;  4COX A;  4D0F A;  1FFM A;  4XLW A;  1U8C B;  5IKT A;  1KLO A;  1OB1 C;  4YT6 L;  1AUT L;  2VH6 B;  3ZYG A;  1YO8 A;  1V1H A;  1WHF A;  2W2M E;  2VVU L;  4MMX B;  1CCV A;  1NFY B;  3M36 L;  4LOR A;  4ZHA B;  3QH0 A;  2Y80 B;  1GK5 A;  2Y5H L;  2BQ6 A;  3GCX E;  3RR3 A;  1NT0 A;  2I9A A;  1JV2 B;  2BOX A;  4YZU B;  2ADX A;  2WG3 C;  1COU A;  1YUF A;  3POY A;  3GCW E;  4AQT A;  3N8V A;  1Q4G A;  1NPE B;  3FBY A;  3M37 L;  2BOH A;  4X8U L;  1IJQ A;  3HS5 A;  3OLT A;  4RS0 A;  3BPS E;  2AYL A;  1JL9 A;  1RFN B;  1YUG A;  2P95 L;  4BDX A;  4Y76 B;  4Z6A L;  1HT5 A;  2W26 B;  4JZF L;  4BXW A;  3LTF B;  1DVA L;  1WHE A;  2VRS A;  5I46 L;  3GIS X;  4Z0L A;  3N8Y B;  2FZZ L;  3P5B L;  4OTY A;  1XFE A;  3K9X A;  3LTG D;  2WZP P;  2J94 B;  3DEM A;  1J9C L;  4BXS A;  1NZI A;  2UWL B;  1NFW B;  2BT7 A;  1KIG L;  2CJI B;  2WPJ E;  5F1A A;  1I0U A;  2W3K B;  1W7X L;  2FLB L;  2P16 L;  4M11 A;  3SOV A;  3TK6 B;  2J4I B;  4BTT A;  3ELA L;  3KQC L;  3HS6 A;  1LPZ A;  2UWP B;  2WPI E;  1FAX L;  1EMO A;  2Y7X B;  1TPG A;  2EI6 B;  2YGP A;  1MQ5 L;  1UZQ A;  5JBC E;  3TZI A;  1XDT R;  1DQB A;  1MQ6 L;  2F9B L;  3NT1 A;  2PHB B;  4X8S L;  3NTB A;  1EBV A;  3V64 C;  2KNI A;  1HZ8 A;  2VVC K;  4OTJ A;  1IOX A;  1ADX A;  5F19 A;  1ATD A;  3QMO A;  4ISI L;  5KN5 C;  4PH9 A;  1IQK L;  2VVV L;  1IQJ L;  2VWO L;  3PGH A;  3KQD L;  4GU4 A;  1IQL L;  2K2T A;  4JYU L;  2NPR A;  2BMG A;  3HO5 A;  2WFX B;  3ENS A;  2D1J B;  2DDU A;  2WYJ B;  1CX2 A;  4Z0K B;  2HOR A;  1LMM A;  1IQE L;  4M10 A;  2VH0 B;  2W2Q E;  1JBU L;  2MGP A;  6COX A;  3FCS B;  2J38 B;  4RRY A;  3KRK A;  1F0R B;  1QFK L;  1U67 A;  1KLJ L;  5KIR A;  2JJL A;  1IP0 A;  2PR3 B;  2HOX A;  2WPH E;  1CVW L;  2YGQ A;  1YUK B;  1G1Q A;  2P28 B;  2FLR L;  3LC3 B;  1FF7 A;  3LN1 A;  4G1M B;  1UZP A;  2B7D L;  4RRW A;  3CEN L;  1EPI A;  2EI8 B;  5FDQ A;  1EGF A;  4Y7A B;  1G2M B;  1W8B L;  3BT1 A;  1IQM L;  2OYU P;  4Y6D B;  1PFX L;  1CEJ A;  1IOE L;  2UWO B;  3TH3 L;  1IGZ A;  4RUT A;  3LIW B;  1EZQ B;  1N1I A;  5IKQ A;  3IIT B;  1MOX C;  1EAI C;  2J2U B;  2W2O E;  4XBM A;  1EPJ A;  4JZE L;  1UZJ A;  2FLG A;  2JKH L;  5CKQ A;  1L5G B;  3QCW A;  2BOK L;  3KQB L;  1G1R A;  5IKV A;  4D90 A;  3KK6 A;  1HT8 A;  1M1X B;  3Q3K B;  2K2S B;  3S6X A;  4O02 B;  2XC0 L;  1LPG A;  3N8W B;  1NQL B;  4JZD L;  2YGO A;  4ZXY L;  1X7A L;  1IGX A;  5L30 L;  2XBW L;  4MMY B;  1ATA A;  1URK A;  2Y82 B;  4D0E A;  4YT7 L;  5JB9 E;  2H9E C;  1HJ7 A;  3LC5 B;  4C16 A;  4CSY A;  3SW2 A;  1EPH A;  3U73 A;  1L3Y A;  5JB8 E;  1ZAQ A;  1WU1 B;  1XKB A;  4O1Z A;  1EPG A;  1PTH A;  1V3X B;  2MHP A;  2RA0 L;  1FAK L;  3HS7 A;  3CA7 A;  3MQE A;  3TK5 B;  2RNL A;  1NFX B;  4BDW A;  3CS7 L;  1HRE A;  2M74 A;  4Y7B B;  3TGF A;  2BSF A;  4BTU A;  1IVO C;  4MMZ B;  2XBV L;  4Y71 B;  2KV4 A;  1P9J A;  2P94 L;  1TOZ A;  4CUE A;  3HPT A;  1APQ A;  3SOB B;  4BTI A;  1YGC L;  1KLI L;  5JW1 A;  2P93 L;  2BOU A;  5CKN A;  3KL6 B;  3LAQ A;  3TBD A;  5JVZ A;  1DX5 I;  3SOQ A;  3N8Y A;  2BQ7 A;  3ASI A;  1CVU A;  3HO4 A;  1V1I A;  1IQN L;  1PRH A;  2WYG B;  5L2Y L;  3ZYJ B;  3NJP C;  2G00 L;  5JBB E;  3CFW A;  1UZK A;  2Y5G L;  2W3I B;  5EGM B;  1Z6E L;  2EI7 B;  3F1S B;  2Y7Z B;  3N8X A;  1N7D A;  2WFT A;  1LK9 A;  2Y81 B;  1KKE A;  1P0S L;  4NGA L;  1XKA L;  2GD4 A;  3EGF A;  2MGR A;  2WPK E;  5JBA E;  1HX2 A;  2W86 A;  2WPM E;  4JYV L;  3NTG A;  4ZAE B;  3OLU A;  1G1S A;  3LN0 A;  4RRZ A;  2XBY L;  3IJE B;  3KQE L;  1CQE A;  2W2P E;  4GU3 A;  1APO A;  1IQH L;  2J95 B;  4LMF A;  3N8Z A;  4ISH L;  1HCG B;  2J34 B;  2FD6 A;  1F0S B;  1LMJ A; 
#chains in the Genus database with same CATH homology
 3Q7D A;  1A3P A;  5K0H B;  5E8D A;  1LQD A;  1FJS L;  1Z6C A;  3H5C B;  1ATE A;  1HAE A;  3MDL A;  1TLE A;  1HAF A;  4XL1 A;  1K37 A;  2P3T A;  2P3F L;  4ZH8 B;  2PUQ L;  2VJ3 A;  3FFG L;  2P3U A;  5JVY A;  4A7I A;  3ZYI B;  1FE2 A;  2TGF A;  1EQG A;  4FM5 A;  2P26 A;  1HRF A;  1NFU B;  5IKR A;  1G1T A;  4X8T L;  4NG9 L;  2BZ6 L;  1FSB A;  1DDX A;  3V65 B;  2XC5 L;  3KCG L;  5CIS A;  4A94 C;  1DIY A;  1IQF L;  2Q1J B;  1PXX A;  2BO2 A;  1B9W A;  2XC4 L;  1ATB A;  2WPL E;  4X8V L;  1F7E A;  1EQH A;  1F7M A;  1SZB A;  4RRX A;  1CCF A;  4ZXX L;  1KSN B;  1LPK A;  4Y79 B;  2OYE P;  3BT2 A;  1K36 A;  5L2Z L;  1BF9 A;  2H9E L;  2VWL L;  3R05 A;  1IQI L;  2VWM K;  2W2N E;  1C5M F;  1PGE A;  2Y5F L;  2WG4 B;  2I9B A;  2RHP A;  3HO3 A;  5CKM A;  2VWN L;  1G2L B;  4CUF A;  5COX A;  2P3F N;  2KL7 A;  4E1G A;  4NA9 L;  4CUD A;  3F6U L;  1O5D L;  3N8W A;  1EMN A;  2KB9 A;  1IQG L;  3U7U G;  2XBX L;  2Y38 A;  2BQW A;  4TGF A;  3C9A C;  4COX A;  4D0F A;  1FFM A;  4XLW A;  1U8C B;  5IKT A;  1KLO A;  1OB1 C;  4YT6 L;  1AUT L;  2VH6 B;  3ZYG A;  1YO8 A;  1WHF A;  2W2M E;  2VVU L;  4MMX B;  1CCV A;  1NFY B;  3M36 L;  4LOR A;  4ZHA B;  3QH0 A;  2Y80 B;  1GK5 A;  2Y5H L;  2BQ6 A;  3GCX E;  3RR3 A;  1NT0 A;  2I9A A;  1JV2 B;  2BOX A;  4YZU B;  2ADX A;  2WG3 C;  1COU A;  1YUF A;  3POY A;  3GCW E;  4AQT A;  3N8V A;  1Q4G A;  1NPE B;  3FBY A;  3M37 L;  2BOH A;  4X8U L;  1IJQ A;  3HS5 A;  3OLT A;  4RS0 A;  3BPS E;  2AYL A;  1JL9 A;  1RFN B;  1YUG A;  2P95 L;  4BDX A;  4Y76 B;  4Z6A L;  1HT5 A;  2W26 B;  4JZF L;  4BXW A;  3LTF B;  1DVA L;  1WHE A;  5I46 L;  3GIS X;  4Z0L A;  3N8Y B;  2FZZ L;  3P5B L;  4OTY A;  1XFE A;  3K9X A;  3LTG D;  2WZP P;  2J94 B;  3DEM A;  1J9C L;  4BXS A;  1NZI A;  2UWL B;  1NFW B;  1KIG L;  2CJI B;  2WPJ E;  5F1A A;  1I0U A;  2W3K B;  1W7X L;  2FLB L;  2P16 L;  4M11 A;  3SOV A;  3TK6 B;  2J4I B;  4BTT A;  3ELA L;  3KQC L;  3HS6 A;  1LPZ A;  2UWP B;  2WPI E;  1FAX L;  1EMO A;  2Y7X B;  1TPG A;  2EI6 B;  2YGP A;  1MQ5 L;  1UZQ A;  5JBC E;  3TZI A;  1XDT R;  1DQB A;  1MQ6 L;  2F9B L;  3NT1 A;  2PHB B;  4X8S L;  3NTB A;  1EBV A;  3V64 C;  2KNI A;  1HZ8 A;  2VVC K;  4OTJ A;  1IOX A;  1ADX A;  5F19 A;  1ATD A;  3QMO A;  4ISI L;  5KN5 C;  4PH9 A;  1IQK L;  2VVV L;  1IQJ L;  2VWO L;  3PGH A;  3KQD L;  1IQL L;  2K2T A;  4JYU L;  2NPR A;  2BMG A;  3HO5 A;  2WFX B;  3ENS A;  2D1J B;  2DDU A;  2WYJ B;  1CX2 A;  4Z0K B;  1LMM A;  1IQE L;  4M10 A;  2VH0 B;  2W2Q E;  1JBU L;  2MGP A;  6COX A;  3FCS B;  2J38 B;  4RRY A;  3KRK A;  1F0R B;  1QFK L;  1U67 A;  1KLJ L;  5KIR A;  1IP0 A;  2PR3 B;  2WPH E;  1CVW L;  2YGQ A;  1YUK B;  1G1Q A;  2P28 B;  2FLR L;  3LC3 B;  1FF7 A;  3LN1 A;  4G1M B;  1UZP A;  2B7D L;  4RRW A;  3CEN L;  1EPI A;  2EI8 B;  5FDQ A;  1EGF A;  4Y7A B;  1G2M B;  1W8B L;  3BT1 A;  1IQM L;  2OYU P;  4Y6D B;  1PFX L;  1CEJ A;  1IOE L;  2UWO B;  3TH3 L;  1IGZ A;  4RUT A;  3LIW B;  1EZQ B;  1N1I A;  5IKQ A;  3IIT B;  1MOX C;  1EAI C;  2J2U B;  2W2O E;  4XBM A;  1EPJ A;  4JZE L;  1UZJ A;  2FLG A;  2JKH L;  5CKQ A;  1L5G B;  3QCW A;  2BOK L;  3KQB L;  1G1R A;  5IKV A;  4D90 A;  3KK6 A;  1HT8 A;  1M1X B;  3Q3K B;  2K2S B;  3S6X A;  4O02 B;  2XC0 L;  1LPG A;  3N8W B;  1NQL B;  4JZD L;  2YGO A;  4ZXY L;  1X7A L;  1IGX A;  5L30 L;  2XBW L;  4MMY B;  1ATA A;  1URK A;  2Y82 B;  4D0E A;  4YT7 L;  5JB9 E;  2H9E C;  1HJ7 A;  3LC5 B;  4C16 A;  4CSY A;  3SW2 A;  1EPH A;  3U73 A;  1L3Y A;  5JB8 E;  1ZAQ A;  1WU1 B;  1XKB A;  4O1Z A;  1EPG A;  1PTH A;  1V3X B;  2MHP A;  2RA0 L;  1FAK L;  3HS7 A;  3CA7 A;  3MQE A;  3TK5 B;  2RNL A;  1NFX B;  4BDW A;  3CS7 L;  1HRE A;  2M74 A;  4Y7B B;  3TGF A;  4BTU A;  1IVO C;  4MMZ B;  2XBV L;  4Y71 B;  2KV4 A;  1P9J A;  2P94 L;  1TOZ A;  4CUE A;  3HPT A;  1APQ A;  3SOB B;  4BTI A;  1YGC L;  1KLI L;  5JW1 A;  2P93 L;  2BOU A;  5CKN A;  3KL6 B;  3LAQ A;  3TBD A;  5JVZ A;  1DX5 I;  3SOQ A;  3N8Y A;  2BQ7 A;  3ASI A;  1CVU A;  3HO4 A;  1IQN L;  1PRH A;  2WYG B;  5L2Y L;  3ZYJ B;  3NJP C;  2G00 L;  5JBB E;  3CFW A;  1UZK A;  2Y5G L;  2W3I B;  5EGM B;  1Z6E L;  2EI7 B;  3F1S B;  2Y7Z B;  3N8X A;  1N7D A;  2WFT A;  2Y81 B;  1P0S L;  4NGA L;  1XKA L;  2GD4 A;  3EGF A;  2MGR A;  2WPK E;  5JBA E;  1HX2 A;  2W86 A;  2WPM E;  4JYV L;  3NTG A;  4ZAE B;  3OLU A;  1G1S A;  3LN0 A;  4RRZ A;  2XBY L;  3IJE B;  3KQE L;  1CQE A;  2W2P E;  1APO A;  1IQH L;  2J95 B;  4LMF A;  3N8Z A;  4ISH L;  1HCG B;  2J34 B;  2FD6 A;  1F0S B;  1LMJ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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