2VH6B

Structure and property based design of factor xa inhibitors: pyrrolidin-2-ones with biaryl p4 motifs
Total Genus 12
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
12
sequence length
54
structure length
54
Chain Sequence
TRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLE
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure and Property Based Design of Factor Xa Inhibitors: Pyrrolidin-2-Ones with Biaryl P4 Motifs.
pubmed doi rcsb
molecule tags Hydrolase
molecule keywords ACTIVATED FACTOR XA HEAVY CHAIN
total genus 12
structure length 54
sequence length 54
ec nomenclature ec 3.4.21.6: Coagulation factor Xa.
pdb deposition date 2007-11-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF00008 EGF EGF-like domain
B PF14670 FXa_inhibition Coagulation Factor Xa inhibitory site
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.25.10 Mainly Beta Ribbon Laminin Laminin 2vh6B00
3KQCL 4Y7AB 1FF7A 3NJPC 1EQHA 1EAIC 2WFXB 1LPZA 5L2YL 2P28B 1CCVA 1IVOC 1Z6CA 2KV4A 4YZUB 1EBVA 1WHEA 5COXA 1EQGA 2BOUA 4XL1A 5CISA 2RNLA 1XDTR 1ATAA 1IQJL 3M36L 1G2MB 3K9XA 4O1ZA 4RRWA 4X8UL 4ZXYL 4BTUA 2FD6A 4D90A 3LN1A 2KL7A 3F6UL 3HS6A 3HO3A 4FM5A 4X8TL 2Q1JB 1URKA 4MMZB 4ZAEB 1RFNB 3OLUA 1U8CB 1MQ6L 1FAKL 4PH9A 5F19A 2K2SB 4ISHL 2J34B 3SOVA 1KSNB 1G1TA 1KLIL 3CFWA 3ASIA 2PR3B 1FAXL 5JBCE 2WG3C 2G00L 4LORA 3ZYJB 3N8VA 1EZQB 5JVYA 1PFXL 2WG4B 3TBDA 2Y5HL 1CQEA 1EMNA 2BQWA 1K37A 2P94L 3LC5B 1HJ7A 1G1RA 2WPIE 2MHPA 3KQEL 1DIYA 2WYGB 3BT1A 1FSBA 3FCSB 5F1AA 1W8BL 2M74A 3KL6B 1IQIL 3LAQA 2BOXA 1X7AL 1L5GB 2W2ME 3SW2A 4RS0A 2PUQL 4JYUL 3LTFB 4JYVL 3U7UG 4BTTA 1KLJL 2BMGA 4MMYB 1LPGA 4OTYA 1WU1B 1DDXA 3C9AC 2Y80B 2RHPA 4OTJA 2WPME 2J4IB 3TZIA 1KLOA 3QCWA 1TOZA 1MQ5L 2EI7B 5EGMB 2XC0L 1CCFA 2RA0L 2J94B 1YGCL 2BZ6L 2Y7XB 5IKVA 1NFYB 3R05A 1PTHA 1IQLL 2FLBL 2K2TA 4Y79B 1F0SB 1IQHL 3KQDL 4D0EA 1G1SA 1F7EA 1ZAQA 4M10A 3TH3L 4RRZA 2BQ7A 2KB9A 4RRXA 1HREA 1M1XB 1N1IA 5IKRA 3TK6B 1FFMA 2ADXA 3ZYIB 5JBAE 1I0UA 3H5CB 4G1MB 4XLWA 1YUFA 5KIRA 2VVCK 3HO4A 2OYUP 4NA9L 1FE2A 1HZ8A 2Y7ZB 2B7DL 1NFWB 2P3FL 2CJIB 1NFUB 2FZZL 3IITB 4Y71B 1IQKL 1HT5A 1PRHA 5JVZA 5JBBE 4Z0LA 3QH0A 3KCGL 3ELAL 5L2ZL 4Z0KB 1EPHA 1HAFA 1BF9A 2Y5FL 5CKQA 1B9WA 4NGAL 4X8SL 5IKQA 1NQLB 3CENL 5I46L 4NG9L 2WYJB 1IJQA 2WPJE 2NPRA 3SOQA 1XFEA 1EMOA 3MQEA 1IGXA 4BDXA 1IOXA 2H9EL 2XC4L 2W86A 1UZQA 2W2QE 4XBMA 5JW1A 4BXWA 2I9BA 1FJSL 1F7MA 3NTBA 1CEJA 5K0HB 1N7DA 1EPJA 1MOXC 3TGFA 1DX5I 3CA7A 4Y7BB 1NZIA 2Y82B 1IQML 4ZH8B 4MMXB 3HPTA 4X8VL 5JB9E 1UZPA 2YGPA 2P95L 2VWMK 2EI6B 3BPSE 3N8XA 1ADXA 2UWPB 3LTGD 2VH6B 4BXSA 2F9BL 3GCXE 2WPLE 1NT0A 4M11A 1ATEA 3M37L 2AYLA 1NPEB 1IP0A 2BOKL 1CX2A 2P3TA 3DEMA 2Y38A 4Z6AL 2P93L 4ISIL 2MGRA 2J38B 5CKNA 4YT7L 2W2PE 2VWNL 1UZKA 2W3KB 4ZXXL 1AUTL 1IQEL 2W26B 1PXXA 2P16L 1HAEA 2J2UB 1F0RB 3POYA 2OYEP 1WHFA 3MDLA 2XC5L 2BOHA 1HRFA 3KRKA 4COXA 2D1JB 1HX2A 1IOEL 2W2NE 5L30L 3FBYA 1TLEA 5E8DA 3OLTA 3LIWB 4D0FA 2Y81B 3BT2A 1EPGA 2W3IB 1J9CL 5FDQA 2BO2A 4LMFA 3NT1A 1JL9A 4Y76B 5CKMA 3N8YA 1LMJA 1IQFL 2P3UA 4YT6L 2WPHE 2VWLL 4O02B 1P0SL 2UWOB 2PHBB 1QFKL 2VWOL 4AQTA 1DQBA 5JB8E 4CUEA 3HO5A 5KN5C 1APOA 1Z6EL 2JKHL 3N8ZA 5IKTA 1APQA 2P3FN 3FFGL 2TGFA 3V64C 1Q4GA 4JZDL 3HS5A 1UZJA 3F1SB 1LQDA 2I9AA 4Y6DB 2MGPA 2XBXL 3NTGA 2Y5GL 2P26A 6COXA 1TPGA 2GD4A 1COUA 3P5BL 1IGZA 4C16A 1EPIA 3LC3B 4JZFL 2DDUA 3RR3A 1A3PA 2XBWL 3GCWE 1XKAL 3Q3KB 1GK5A 1P9JA 1PGEA 1U67A 1OB1C 2WFTA 1IQGL 3N8YB 3GISX 4BDWA 3N8WA 3IJEB 2W2OE 2YGOA 1SZBA 3SOBB 1YUKB 2FLRL 2VVUL 2UWLB 1C5MF 1XKBA 2J95B 1L3YA 4JZEL 1YUGA 1HT8A 3LN0A 1KIGL 3KK6A 2BQ6A 2WPKE 4RRYA 2XBVL 4CUDA 3QMOA 1G1QA 3Q7DA 3V65B 3TK5B 4BTIA 1IQNL 1CVWL 1JV2B 2FLGA 2XBYL 4CUFA 3PGHA 4E1GA 3U73A 3EGFA 1ATBA 1JBUL 1HCGB 2VH0B 1DVAL 2VVVL 1V3XB 3ENSA 4A7IA 1NFXB 3KQBL 2EI8B 1YO8A 1K36A 1G2LB 3ZYGA 3HS7A 2VJ3A 1O5DL 4CSYA 4RUTA 4TGFA 1EGFA 1W7XL 1CVUA 4ZHAB 1ATDA 3N8WB 1LPKA 3CS7L
chains in the Genus database with same CATH superfamily
3KQCL 4Y7AB 1FF7A 3NJPC 1EQHA 1EAIC 2WFXB 1LPZA 5L2YL 2P28B 1CCVA 1IVOC 1Z6CA 2KV4A 4YZUB 1EBVA 1WHEA 5COXA 1EQGA 2BOUA 4XL1A 5CISA 2RNLA 1XDTR 1ATAA 1IQJL 3M36L 1G2MB 3K9XA 4O1ZA 4RRWA 4X8UL 4ZXYL 4BTUA 2FD6A 4D90A 3LN1A 2KL7A 3F6UL 3HS6A 3HO3A 4FM5A 4X8TL 2Q1JB 1URKA 4MMZB 4ZAEB 1RFNB 3OLUA 1U8CB 1MQ6L 1FAKL 4PH9A 5F19A 2K2SB 4ISHL 2J34B 3SOVA 1KSNB 1G1TA 1KLIL 3CFWA 3ASIA 4GU3A 2PR3B 2HORA 1FAXL 5JBCE 2WG3C 2G00L 4LORA 3ZYJB 3N8VA 1EZQB 5JVYA 1PFXL 2WG4B 3TBDA 2Y5HL 1CQEA 1EMNA 2BQWA 1K37A 2P94L 3LC5B 1HJ7A 1G1RA 2WPIE 2MHPA 3KQEL 1DIYA 2WYGB 3BT1A 1FSBA 3FCSB 5F1AA 1W8BL 2M74A 1LK9A 3KL6B 1IQIL 3LAQA 2BOXA 1X7AL 1L5GB 2W2ME 3SW2A 4RS0A 2PUQL 4JYUL 3LTFB 4JYVL 3U7UG 4BTTA 2BT8A 1KLJL 2BMGA 4MMYB 1LPGA 4OTYA 1WU1B 3S6XA 1DDXA 3C9AC 2Y80B 2RHPA 4OTJA 2WPME 2J4IB 3TZIA 1KLOA 3QCWA 1TOZA 1MQ5L 2EI7B 5EGMB 2XC0L 1LMMA 1CCFA 2RA0L 2J94B 1YGCL 2BZ6L 2Y7XB 5IKVA 1NFYB 3R05A 2H9EC 1PTHA 1IQLL 2FLBL 2K2TA 4Y79B 1F0SB 1IQHL 3KQDL 4D0EA 1G1SA 1F7EA 1ZAQA 4M10A 3TH3L 4RRZA 2BQ7A 2KB9A 4RRXA 1HREA 1M1XB 1N1IA 5IKRA 3TK6B 1FFMA 2ADXA 3ZYIB 5JBAE 1I0UA 3H5CB 4G1MB 4XLWA 1YUFA 4GU4A 5KIRA 2VVCK 3HO4A 4A94C 2OYUP 4NA9L 1FE2A 1HZ8A 2Y7ZB 2HOXA 2B7DL 1NFWB 2P3FL 2CJIB 1NFUB 2FZZL 3IITB 4Y71B 1IQKL 1HT5A 1PRHA 5JVZA 5JBBE 4Z0LA 3QH0A 3KCGL 3ELAL 5L2ZL 4Z0KB 1EPHA 1HAFA 1BF9A 2Y5FL 5CKQA 1B9WA 4NGAL 4X8SL 5IKQA 1NQLB 3CENL 5I46L 4NG9L 2WYJB 1IJQA 2WPJE 2NPRA 3SOQA 1XFEA 1EMOA 3MQEA 1IGXA 4BDXA 1IOXA 2H9EL 2XC4L 2W86A 1UZQA 2W2QE 4XBMA 5JW1A 4BXWA 2I9BA 1FJSL 1F7MA 3NTBA 1CEJA 5K0HB 1N7DA 1EPJA 1MOXC 3TGFA 1DX5I 3CA7A 4Y7BB 2YGQA 1NZIA 2Y82B 1IQML 4ZH8B 4MMXB 3HPTA 4X8VL 5JB9E 1UZPA 2YGPA 2P95L 2VRSA 2VWMK 2EI6B 3BPSE 3N8XA 1ADXA 2UWPB 3LTGD 2VH6B 4BXSA 2F9BL 3GCXE 2WPLE 1NT0A 4M11A 1ATEA 2BSFA 3M37L 2AYLA 1NPEB 1IP0A 2BOKL 1CX2A 2P3TA 3DEMA 2Y38A 4Z6AL 2P93L 4ISIL 2MGRA 2J38B 5CKNA 4YT7L 2W2PE 2VWNL 1UZKA 2W3KB 4ZXXL 1AUTL 1IQEL 2W26B 1PXXA 2P16L 1HAEA 2J2UB 1F0RB 3POYA 2OYEP 1WHFA 3MDLA 2XC5L 2BOHA 1HRFA 3KRKA 4COXA 2D1JB 1HX2A 1IOEL 2W2NE 5L30L 3FBYA 1TLEA 5E8DA 3OLTA 3LIWB 4D0FA 2Y81B 3BT2A 1EPGA 2W3IB 1J9CL 5FDQA 2BO2A 4LMFA 3NT1A 1JL9A 4Y76B 5CKMA 3N8YA 1LMJA 1IQFL 2P3UA 4YT6L 2WPHE 2VWLL 4O02B 1P0SL 2UWOB 2PHBB 1QFKL 2VWOL 4AQTA 1QIUA 1DQBA 5JB8E 4CUEA 3HO5A 5KN5C 1APOA 1Z6EL 2JKHL 3N8ZA 5IKTA 1APQA 2P3FN 3FFGL 2TGFA 3V64C 1Q4GA 4JZDL 3HS5A 1UZJA 3F1SB 1LQDA 2I9AA 4Y6DB 2MGPA 2XBXL 3NTGA 2Y5GL 2P26A 6COXA 1TPGA 2GD4A 2JJLA 1COUA 3P5BL 1IGZA 4C16A 1EPIA 3LC3B 4JZFL 2DDUA 3RR3A 1A3PA 2XBWL 2KNIA 3GCWE 1XKAL 3Q3KB 1GK5A 1P9JA 1PGEA 1U67A 1OB1C 2WFTA 1IQGL 3N8YB 3GISX 4BDWA 3N8WA 3IJEB 2W2OE 2YGOA 1SZBA 3SOBB 1YUKB 2FLRL 2VVUL 2UWLB 1C5MF 1XKBA 2J95B 1L3YA 4JZEL 1YUGA 1HT8A 3LN0A 1KIGL 1KKEA 3KK6A 2BQ6A 2WPKE 4RRYA 2XBVL 4CUDA 3QMOA 1G1QA 3Q7DA 1V1IA 3V65B 3TK5B 4BTIA 1IQNL 1CVWL 1JV2B 2FLGA 2XBYL 4CUFA 3PGHA 4E1GA 3U73A 3EGFA 1ATBA 1JBUL 1HCGB 2VH0B 1DVAL 2VVVL 1V3XB 3ENSA 4A7IA 1NFXB 3KQBL 2EI8B 1YO8A 1K36A 1G2LB 2WZPP 2BT7A 3ZYGA 3HS7A 2VJ3A 1O5DL 4CSYA 4RUTA 4TGFA 1EGFA 1W7XL 1CVUA 4ZHAB 1V1HA 1ATDA 3N8WB 1LPKA 3CS7L
chains in the Genus database with same CATH topology
3KQCL 4Y7AB 1FF7A 3NJPC 1EQHA 1EAIC 2WFXB 1LPZA 5L2YL 2P28B 1CCVA 1IVOC 1Z6CA 2KV4A 4YZUB 1EBVA 1WHEA 5COXA 1EQGA 2BOUA 4XL1A 5CISA 2RNLA 1XDTR 1ATAA 1IQJL 3M36L 1G2MB 3K9XA 4O1ZA 4RRWA 4X8UL 4ZXYL 4BTUA 2FD6A 4D90A 3LN1A 2KL7A 3F6UL 3HS6A 3HO3A 4FM5A 4X8TL 2Q1JB 1URKA 4MMZB 4ZAEB 1RFNB 3OLUA 1U8CB 1MQ6L 1FAKL 4PH9A 5F19A 2K2SB 4ISHL 2J34B 3SOVA 1KSNB 1G1TA 1KLIL 3CFWA 3ASIA 2PR3B 1FAXL 5JBCE 2WG3C 2G00L 4LORA 3ZYJB 3N8VA 1EZQB 5JVYA 1PFXL 2WG4B 3TBDA 2Y5HL 1CQEA 1EMNA 2BQWA 1K37A 2P94L 3LC5B 1HJ7A 1G1RA 2WPIE 2MHPA 3KQEL 1DIYA 2WYGB 3BT1A 1FSBA 3FCSB 5F1AA 1W8BL 2M74A 3KL6B 1IQIL 3LAQA 2BOXA 1X7AL 1L5GB 2W2ME 3SW2A 4RS0A 2PUQL 4JYUL 3LTFB 4JYVL 3U7UG 4BTTA 1KLJL 2BMGA 4MMYB 1LPGA 4OTYA 1WU1B 3S6XA 1DDXA 3C9AC 2Y80B 2RHPA 4OTJA 2WPME 2J4IB 3TZIA 1KLOA 3QCWA 1TOZA 1MQ5L 2EI7B 5EGMB 2XC0L 1LMMA 1CCFA 2RA0L 2J94B 1YGCL 2BZ6L 2Y7XB 5IKVA 1NFYB 3R05A 2H9EC 1PTHA 1IQLL 2FLBL 2K2TA 4Y79B 1F0SB 1IQHL 3KQDL 4D0EA 1G1SA 1F7EA 1ZAQA 4M10A 3TH3L 4RRZA 2BQ7A 2KB9A 4RRXA 1HREA 1M1XB 1N1IA 5IKRA 3TK6B 1FFMA 2ADXA 3ZYIB 5JBAE 1I0UA 3H5CB 4G1MB 4XLWA 1YUFA 5KIRA 2VVCK 3HO4A 4A94C 2OYUP 4NA9L 1FE2A 1HZ8A 2Y7ZB 2B7DL 1NFWB 2P3FL 2CJIB 1NFUB 2FZZL 3IITB 4Y71B 1IQKL 1HT5A 1PRHA 5JVZA 5JBBE 4Z0LA 3QH0A 3KCGL 3ELAL 5L2ZL 4Z0KB 1EPHA 1HAFA 1BF9A 2Y5FL 5CKQA 1B9WA 4NGAL 4X8SL 5IKQA 1NQLB 3CENL 5I46L 4NG9L 2WYJB 1IJQA 2WPJE 2NPRA 3SOQA 1XFEA 1EMOA 3MQEA 1IGXA 4BDXA 1IOXA 2H9EL 2XC4L 2W86A 1UZQA 2W2QE 4XBMA 5JW1A 4BXWA 2I9BA 1FJSL 1F7MA 3NTBA 1CEJA 5K0HB 1N7DA 1EPJA 1MOXC 3TGFA 1DX5I 3CA7A 4Y7BB 2YGQA 1NZIA 2Y82B 1IQML 4ZH8B 4MMXB 3HPTA 4X8VL 5JB9E 1UZPA 2YGPA 2P95L 2VWMK 2EI6B 3BPSE 3N8XA 1ADXA 2UWPB 3LTGD 2VH6B 4BXSA 2F9BL 3GCXE 2WPLE 1NT0A 4M11A 1ATEA 3M37L 2AYLA 1NPEB 1IP0A 2BOKL 1CX2A 2P3TA 3DEMA 2Y38A 4Z6AL 2P93L 4ISIL 2MGRA 2J38B 5CKNA 4YT7L 2W2PE 2VWNL 1UZKA 2W3KB 4ZXXL 1AUTL 1IQEL 2W26B 1PXXA 2P16L 1HAEA 2J2UB 1F0RB 3POYA 2OYEP 1WHFA 3MDLA 2XC5L 2BOHA 1HRFA 3KRKA 4COXA 2D1JB 1HX2A 1IOEL 2W2NE 5L30L 3FBYA 1TLEA 5E8DA 3OLTA 3LIWB 4D0FA 2Y81B 3BT2A 1EPGA 2W3IB 1J9CL 5FDQA 2BO2A 4LMFA 3NT1A 1JL9A 4Y76B 5CKMA 3N8YA 1LMJA 1IQFL 2P3UA 4YT6L 2WPHE 2VWLL 4O02B 1P0SL 2UWOB 2PHBB 1QFKL 2VWOL 4AQTA 1DQBA 5JB8E 4CUEA 3HO5A 5KN5C 1APOA 1Z6EL 2JKHL 3N8ZA 5IKTA 1APQA 2P3FN 3FFGL 2TGFA 3V64C 1Q4GA 4JZDL 3HS5A 1UZJA 3F1SB 1LQDA 2I9AA 4Y6DB 2MGPA 2XBXL 3NTGA 2Y5GL 2P26A 6COXA 1TPGA 2GD4A 1COUA 3P5BL 1IGZA 4C16A 1EPIA 3LC3B 4JZFL 2DDUA 3RR3A 1A3PA 2XBWL 2KNIA 3GCWE 1XKAL 3Q3KB 1GK5A 1P9JA 1PGEA 1U67A 1OB1C 2WFTA 1IQGL 3N8YB 3GISX 4BDWA 3N8WA 3IJEB 2W2OE 2YGOA 1SZBA 3SOBB 1YUKB 2FLRL 2VVUL 2UWLB 1C5MF 1XKBA 2J95B 1L3YA 4JZEL 1YUGA 1HT8A 3LN0A 1KIGL 3KK6A 2BQ6A 2WPKE 4RRYA 2XBVL 4CUDA 3QMOA 1G1QA 3Q7DA 3V65B 3TK5B 4BTIA 1IQNL 1CVWL 1JV2B 2FLGA 2XBYL 4CUFA 3PGHA 4E1GA 3U73A 3EGFA 1ATBA 1JBUL 1HCGB 2VH0B 1DVAL 2VVVL 1V3XB 3ENSA 4A7IA 1NFXB 3KQBL 2EI8B 1YO8A 1K36A 1G2LB 2WZPP 3ZYGA 3HS7A 2VJ3A 1O5DL 4CSYA 4RUTA 4TGFA 1EGFA 1W7XL 1CVUA 4ZHAB 1ATDA 3N8WB 1LPKA 3CS7L
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3KQC L;  4Y7A B;  1FF7 A;  3NJP C;  1EQH A;  1EAI C;  2WFX B;  1LPZ A;  5L2Y L;  2P28 B;  1CCV A;  1IVO C;  1Z6C A;  2KV4 A;  4YZU B;  1EBV A;  1WHE A;  5COX A;  1EQG A;  2BOU A;  4XL1 A;  5CIS A;  2RNL A;  1XDT R;  1ATA A;  1IQJ L;  3M36 L;  1G2M B;  3K9X A;  4O1Z A;  4RRW A;  4X8U L;  4ZXY L;  4BTU A;  2FD6 A;  4D90 A;  3LN1 A;  2KL7 A;  3F6U L;  3HS6 A;  3HO3 A;  4FM5 A;  4X8T L;  2Q1J B;  1URK A;  4MMZ B;  4ZAE B;  1RFN B;  3OLU A;  1U8C B;  1MQ6 L;  1FAK L;  4PH9 A;  5F19 A;  2K2S B;  4ISH L;  2J34 B;  3SOV A;  1KSN B;  1G1T A;  1KLI L;  3CFW A;  3ASI A;  2PR3 B;  1FAX L;  5JBC E;  2WG3 C;  2G00 L;  4LOR A;  3ZYJ B;  3N8V A;  1EZQ B;  5JVY A;  1PFX L;  2WG4 B;  3TBD A;  2Y5H L;  1CQE A;  1EMN A;  2BQW A;  1K37 A;  2P94 L;  3LC5 B;  1HJ7 A;  1G1R A;  2WPI E;  2MHP A;  3KQE L;  1DIY A;  2WYG B;  3BT1 A;  1FSB A;  3FCS B;  5F1A A;  1W8B L;  2M74 A;  3KL6 B;  1IQI L;  3LAQ A;  2BOX A;  1X7A L;  1L5G B;  2W2M E;  3SW2 A;  4RS0 A;  2PUQ L;  4JYU L;  3LTF B;  4JYV L;  3U7U G;  4BTT A;  1KLJ L;  2BMG A;  4MMY B;  1LPG A;  4OTY A;  1WU1 B;  1DDX A;  3C9A C;  2Y80 B;  2RHP A;  4OTJ A;  2WPM E;  2J4I B;  3TZI A;  1KLO A;  3QCW A;  1TOZ A;  1MQ5 L;  2EI7 B;  5EGM B;  2XC0 L;  1CCF A;  2RA0 L;  2J94 B;  1YGC L;  2BZ6 L;  2Y7X B;  5IKV A;  1NFY B;  3R05 A;  1PTH A;  1IQL L;  2FLB L;  2K2T A;  4Y79 B;  1F0S B;  1IQH L;  3KQD L;  4D0E A;  1G1S A;  1F7E A;  1ZAQ A;  4M10 A;  3TH3 L;  4RRZ A;  2BQ7 A;  2KB9 A;  4RRX A;  1HRE A;  1M1X B;  1N1I A;  5IKR A;  3TK6 B;  1FFM A;  2ADX A;  3ZYI B;  5JBA E;  1I0U A;  3H5C B;  4G1M B;  4XLW A;  1YUF A;  5KIR A;  2VVC K;  3HO4 A;  2OYU P;  4NA9 L;  1FE2 A;  1HZ8 A;  2Y7Z B;  2B7D L;  1NFW B;  2P3F L;  2CJI B;  1NFU B;  2FZZ L;  3IIT B;  4Y71 B;  1IQK L;  1HT5 A;  1PRH A;  5JVZ A;  5JBB E;  4Z0L A;  3QH0 A;  3KCG L;  3ELA L;  5L2Z L;  4Z0K B;  1EPH A;  1HAF A;  1BF9 A;  2Y5F L;  5CKQ A;  1B9W A;  4NGA L;  4X8S L;  5IKQ A;  1NQL B;  3CEN L;  5I46 L;  4NG9 L;  2WYJ B;  1IJQ A;  2WPJ E;  2NPR A;  3SOQ A;  1XFE A;  1EMO A;  3MQE A;  1IGX A;  4BDX A;  1IOX A;  2H9E L;  2XC4 L;  2W86 A;  1UZQ A;  2W2Q E;  4XBM A;  5JW1 A;  4BXW A;  2I9B A;  1FJS L;  1F7M A;  3NTB A;  1CEJ A;  5K0H B;  1N7D A;  1EPJ A;  1MOX C;  3TGF A;  1DX5 I;  3CA7 A;  4Y7B B;  1NZI A;  2Y82 B;  1IQM L;  4ZH8 B;  4MMX B;  3HPT A;  4X8V L;  5JB9 E;  1UZP A;  2YGP A;  2P95 L;  2VWM K;  2EI6 B;  3BPS E;  3N8X A;  1ADX A;  2UWP B;  3LTG D;  2VH6 B;  4BXS A;  2F9B L;  3GCX E;  2WPL E;  1NT0 A;  4M11 A;  1ATE A;  3M37 L;  2AYL A;  1NPE B;  1IP0 A;  2BOK L;  1CX2 A;  2P3T A;  3DEM A;  2Y38 A;  4Z6A L;  2P93 L;  4ISI L;  2MGR A;  2J38 B;  5CKN A;  4YT7 L;  2W2P E;  2VWN L;  1UZK A;  2W3K B;  4ZXX L;  1AUT L;  1IQE L;  2W26 B;  1PXX A;  2P16 L;  1HAE A;  2J2U B;  1F0R B;  3POY A;  2OYE P;  1WHF A;  3MDL A;  2XC5 L;  2BOH A;  1HRF A;  3KRK A;  4COX A;  2D1J B;  1HX2 A;  1IOE L;  2W2N E;  5L30 L;  3FBY A;  1TLE A;  5E8D A;  3OLT A;  3LIW B;  4D0F A;  2Y81 B;  3BT2 A;  1EPG A;  2W3I B;  1J9C L;  5FDQ A;  2BO2 A;  4LMF A;  3NT1 A;  1JL9 A;  4Y76 B;  5CKM A;  3N8Y A;  1LMJ A;  1IQF L;  2P3U A;  4YT6 L;  2WPH E;  2VWL L;  4O02 B;  1P0S L;  2UWO B;  2PHB B;  1QFK L;  2VWO L;  4AQT A;  1DQB A;  5JB8 E;  4CUE A;  3HO5 A;  5KN5 C;  1APO A;  1Z6E L;  2JKH L;  3N8Z A;  5IKT A;  1APQ A;  2P3F N;  3FFG L;  2TGF A;  3V64 C;  1Q4G A;  4JZD L;  3HS5 A;  1UZJ A;  3F1S B;  1LQD A;  2I9A A;  4Y6D B;  2MGP A;  2XBX L;  3NTG A;  2Y5G L;  2P26 A;  6COX A;  1TPG A;  2GD4 A;  1COU A;  3P5B L;  1IGZ A;  4C16 A;  1EPI A;  3LC3 B;  4JZF L;  2DDU A;  3RR3 A;  1A3P A;  2XBW L;  3GCW E;  1XKA L;  3Q3K B;  1GK5 A;  1P9J A;  1PGE A;  1U67 A;  1OB1 C;  2WFT A;  1IQG L;  3N8Y B;  3GIS X;  4BDW A;  3N8W A;  3IJE B;  2W2O E;  2YGO A;  1SZB A;  3SOB B;  1YUK B;  2FLR L;  2VVU L;  2UWL B;  1C5M F;  1XKB A;  2J95 B;  1L3Y A;  4JZE L;  1YUG A;  1HT8 A;  3LN0 A;  1KIG L;  3KK6 A;  2BQ6 A;  2WPK E;  4RRY A;  2XBV L;  4CUD A;  3QMO A;  1G1Q A;  3Q7D A;  3V65 B;  3TK5 B;  4BTI A;  1IQN L;  1CVW L;  1JV2 B;  2FLG A;  2XBY L;  4CUF A;  3PGH A;  4E1G A;  3U73 A;  3EGF A;  1ATB A;  1JBU L;  1HCG B;  2VH0 B;  1DVA L;  2VVV L;  1V3X B;  3ENS A;  4A7I A;  1NFX B;  3KQB L;  2EI8 B;  1YO8 A;  1K36 A;  1G2L B;  3ZYG A;  3HS7 A;  2VJ3 A;  1O5D L;  4CSY A;  4RUT A;  4TGF A;  1EGF A;  1W7X L;  1CVU A;  4ZHA B;  1ATD A;  3N8W B;  1LPK A;  3CS7 L; 
#chains in the Genus database with same CATH topology
 3KQC L;  4Y7A B;  1FF7 A;  3NJP C;  1EQH A;  1EAI C;  2WFX B;  1LPZ A;  5L2Y L;  2P28 B;  1CCV A;  1IVO C;  1Z6C A;  2KV4 A;  4YZU B;  1EBV A;  1WHE A;  5COX A;  1EQG A;  2BOU A;  4XL1 A;  5CIS A;  2RNL A;  1XDT R;  1ATA A;  1IQJ L;  3M36 L;  1G2M B;  3K9X A;  4O1Z A;  4RRW A;  4X8U L;  4ZXY L;  4BTU A;  2FD6 A;  4D90 A;  3LN1 A;  2KL7 A;  3F6U L;  3HS6 A;  3HO3 A;  4FM5 A;  4X8T L;  2Q1J B;  1URK A;  4MMZ B;  4ZAE B;  1RFN B;  3OLU A;  1U8C B;  1MQ6 L;  1FAK L;  4PH9 A;  5F19 A;  2K2S B;  4ISH L;  2J34 B;  3SOV A;  1KSN B;  1G1T A;  1KLI L;  3CFW A;  3ASI A;  4GU3 A;  2PR3 B;  2HOR A;  1FAX L;  5JBC E;  2WG3 C;  2G00 L;  4LOR A;  3ZYJ B;  3N8V A;  1EZQ B;  5JVY A;  1PFX L;  2WG4 B;  3TBD A;  2Y5H L;  1CQE A;  1EMN A;  2BQW A;  1K37 A;  2P94 L;  3LC5 B;  1HJ7 A;  1G1R A;  2WPI E;  2MHP A;  3KQE L;  1DIY A;  2WYG B;  3BT1 A;  1FSB A;  3FCS B;  5F1A A;  1W8B L;  2M74 A;  1LK9 A;  3KL6 B;  1IQI L;  3LAQ A;  2BOX A;  1X7A L;  1L5G B;  2W2M E;  3SW2 A;  4RS0 A;  2PUQ L;  4JYU L;  3LTF B;  4JYV L;  3U7U G;  4BTT A;  2BT8 A;  1KLJ L;  2BMG A;  4MMY B;  1LPG A;  4OTY A;  1WU1 B;  3S6X A;  1DDX A;  3C9A C;  2Y80 B;  2RHP A;  4OTJ A;  2WPM E;  2J4I B;  3TZI A;  1KLO A;  3QCW A;  1TOZ A;  1MQ5 L;  2EI7 B;  5EGM B;  2XC0 L;  1LMM A;  1CCF A;  2RA0 L;  2J94 B;  1YGC L;  2BZ6 L;  2Y7X B;  5IKV A;  1NFY B;  3R05 A;  2H9E C;  1PTH A;  1IQL L;  2FLB L;  2K2T A;  4Y79 B;  1F0S B;  1IQH L;  3KQD L;  4D0E A;  1G1S A;  1F7E A;  1ZAQ A;  4M10 A;  3TH3 L;  4RRZ A;  2BQ7 A;  2KB9 A;  4RRX A;  1HRE A;  1M1X B;  1N1I A;  5IKR A;  3TK6 B;  1FFM A;  2ADX A;  3ZYI B;  5JBA E;  1I0U A;  3H5C B;  4G1M B;  4XLW A;  1YUF A;  4GU4 A;  5KIR A;  2VVC K;  3HO4 A;  4A94 C;  2OYU P;  4NA9 L;  1FE2 A;  1HZ8 A;  2Y7Z B;  2HOX A;  2B7D L;  1NFW B;  2P3F L;  2CJI B;  1NFU B;  2FZZ L;  3IIT B;  4Y71 B;  1IQK L;  1HT5 A;  1PRH A;  5JVZ A;  5JBB E;  4Z0L A;  3QH0 A;  3KCG L;  3ELA L;  5L2Z L;  4Z0K B;  1EPH A;  1HAF A;  1BF9 A;  2Y5F L;  5CKQ A;  1B9W A;  4NGA L;  4X8S L;  5IKQ A;  1NQL B;  3CEN L;  5I46 L;  4NG9 L;  2WYJ B;  1IJQ A;  2WPJ E;  2NPR A;  3SOQ A;  1XFE A;  1EMO A;  3MQE A;  1IGX A;  4BDX A;  1IOX A;  2H9E L;  2XC4 L;  2W86 A;  1UZQ A;  2W2Q E;  4XBM A;  5JW1 A;  4BXW A;  2I9B A;  1FJS L;  1F7M A;  3NTB A;  1CEJ A;  5K0H B;  1N7D A;  1EPJ A;  1MOX C;  3TGF A;  1DX5 I;  3CA7 A;  4Y7B B;  2YGQ A;  1NZI A;  2Y82 B;  1IQM L;  4ZH8 B;  4MMX B;  3HPT A;  4X8V L;  5JB9 E;  1UZP A;  2YGP A;  2P95 L;  2VRS A;  2VWM K;  2EI6 B;  3BPS E;  3N8X A;  1ADX A;  2UWP B;  3LTG D;  2VH6 B;  4BXS A;  2F9B L;  3GCX E;  2WPL E;  1NT0 A;  4M11 A;  1ATE A;  2BSF A;  3M37 L;  2AYL A;  1NPE B;  1IP0 A;  2BOK L;  1CX2 A;  2P3T A;  3DEM A;  2Y38 A;  4Z6A L;  2P93 L;  4ISI L;  2MGR A;  2J38 B;  5CKN A;  4YT7 L;  2W2P E;  2VWN L;  1UZK A;  2W3K B;  4ZXX L;  1AUT L;  1IQE L;  2W26 B;  1PXX A;  2P16 L;  1HAE A;  2J2U B;  1F0R B;  3POY A;  2OYE P;  1WHF A;  3MDL A;  2XC5 L;  2BOH A;  1HRF A;  3KRK A;  4COX A;  2D1J B;  1HX2 A;  1IOE L;  2W2N E;  5L30 L;  3FBY A;  1TLE A;  5E8D A;  3OLT A;  3LIW B;  4D0F A;  2Y81 B;  3BT2 A;  1EPG A;  2W3I B;  1J9C L;  5FDQ A;  2BO2 A;  4LMF A;  3NT1 A;  1JL9 A;  4Y76 B;  5CKM A;  3N8Y A;  1LMJ A;  1IQF L;  2P3U A;  4YT6 L;  2WPH E;  2VWL L;  4O02 B;  1P0S L;  2UWO B;  2PHB B;  1QFK L;  2VWO L;  4AQT A;  1QIU A;  1DQB A;  5JB8 E;  4CUE A;  3HO5 A;  5KN5 C;  1APO A;  1Z6E L;  2JKH L;  3N8Z A;  5IKT A;  1APQ A;  2P3F N;  3FFG L;  2TGF A;  3V64 C;  1Q4G A;  4JZD L;  3HS5 A;  1UZJ A;  3F1S B;  1LQD A;  2I9A A;  4Y6D B;  2MGP A;  2XBX L;  3NTG A;  2Y5G L;  2P26 A;  6COX A;  1TPG A;  2GD4 A;  2JJL A;  1COU A;  3P5B L;  1IGZ A;  4C16 A;  1EPI A;  3LC3 B;  4JZF L;  2DDU A;  3RR3 A;  1A3P A;  2XBW L;  2KNI A;  3GCW E;  1XKA L;  3Q3K B;  1GK5 A;  1P9J A;  1PGE A;  1U67 A;  1OB1 C;  2WFT A;  1IQG L;  3N8Y B;  3GIS X;  4BDW A;  3N8W A;  3IJE B;  2W2O E;  2YGO A;  1SZB A;  3SOB B;  1YUK B;  2FLR L;  2VVU L;  2UWL B;  1C5M F;  1XKB A;  2J95 B;  1L3Y A;  4JZE L;  1YUG A;  1HT8 A;  3LN0 A;  1KIG L;  1KKE A;  3KK6 A;  2BQ6 A;  2WPK E;  4RRY A;  2XBV L;  4CUD A;  3QMO A;  1G1Q A;  3Q7D A;  1V1I A;  3V65 B;  3TK5 B;  4BTI A;  1IQN L;  1CVW L;  1JV2 B;  2FLG A;  2XBY L;  4CUF A;  3PGH A;  4E1G A;  3U73 A;  3EGF A;  1ATB A;  1JBU L;  1HCG B;  2VH0 B;  1DVA L;  2VVV L;  1V3X B;  3ENS A;  4A7I A;  1NFX B;  3KQB L;  2EI8 B;  1YO8 A;  1K36 A;  1G2L B;  2WZP P;  2BT7 A;  3ZYG A;  3HS7 A;  2VJ3 A;  1O5D L;  4CSY A;  4RUT A;  4TGF A;  1EGF A;  1W7X L;  1CVU A;  4ZHA B;  1V1H A;  1ATD A;  3N8W B;  1LPK A;  3CS7 L; 
#chains in the Genus database with same CATH homology
 3KQC L;  4Y7A B;  1FF7 A;  3NJP C;  1EQH A;  1EAI C;  2WFX B;  1LPZ A;  5L2Y L;  2P28 B;  1CCV A;  1IVO C;  1Z6C A;  2KV4 A;  4YZU B;  1EBV A;  1WHE A;  5COX A;  1EQG A;  2BOU A;  4XL1 A;  5CIS A;  2RNL A;  1XDT R;  1ATA A;  1IQJ L;  3M36 L;  1G2M B;  3K9X A;  4O1Z A;  4RRW A;  4X8U L;  4ZXY L;  4BTU A;  2FD6 A;  4D90 A;  3LN1 A;  2KL7 A;  3F6U L;  3HS6 A;  3HO3 A;  4FM5 A;  4X8T L;  2Q1J B;  1URK A;  4MMZ B;  4ZAE B;  1RFN B;  3OLU A;  1U8C B;  1MQ6 L;  1FAK L;  4PH9 A;  5F19 A;  2K2S B;  4ISH L;  2J34 B;  3SOV A;  1KSN B;  1G1T A;  1KLI L;  3CFW A;  3ASI A;  2PR3 B;  1FAX L;  5JBC E;  2WG3 C;  2G00 L;  4LOR A;  3ZYJ B;  3N8V A;  1EZQ B;  5JVY A;  1PFX L;  2WG4 B;  3TBD A;  2Y5H L;  1CQE A;  1EMN A;  2BQW A;  1K37 A;  2P94 L;  3LC5 B;  1HJ7 A;  1G1R A;  2WPI E;  2MHP A;  3KQE L;  1DIY A;  2WYG B;  3BT1 A;  1FSB A;  3FCS B;  5F1A A;  1W8B L;  2M74 A;  3KL6 B;  1IQI L;  3LAQ A;  2BOX A;  1X7A L;  1L5G B;  2W2M E;  3SW2 A;  4RS0 A;  2PUQ L;  4JYU L;  3LTF B;  4JYV L;  3U7U G;  4BTT A;  1KLJ L;  2BMG A;  4MMY B;  1LPG A;  4OTY A;  1WU1 B;  3S6X A;  1DDX A;  3C9A C;  2Y80 B;  2RHP A;  4OTJ A;  2WPM E;  2J4I B;  3TZI A;  1KLO A;  3QCW A;  1TOZ A;  1MQ5 L;  2EI7 B;  5EGM B;  2XC0 L;  1LMM A;  1CCF A;  2RA0 L;  2J94 B;  1YGC L;  2BZ6 L;  2Y7X B;  5IKV A;  1NFY B;  3R05 A;  2H9E C;  1PTH A;  1IQL L;  2FLB L;  2K2T A;  4Y79 B;  1F0S B;  1IQH L;  3KQD L;  4D0E A;  1G1S A;  1F7E A;  1ZAQ A;  4M10 A;  3TH3 L;  4RRZ A;  2BQ7 A;  2KB9 A;  4RRX A;  1HRE A;  1M1X B;  1N1I A;  5IKR A;  3TK6 B;  1FFM A;  2ADX A;  3ZYI B;  5JBA E;  1I0U A;  3H5C B;  4G1M B;  4XLW A;  1YUF A;  5KIR A;  2VVC K;  3HO4 A;  4A94 C;  2OYU P;  4NA9 L;  1FE2 A;  1HZ8 A;  2Y7Z B;  2B7D L;  1NFW B;  2P3F L;  2CJI B;  1NFU B;  2FZZ L;  3IIT B;  4Y71 B;  1IQK L;  1HT5 A;  1PRH A;  5JVZ A;  5JBB E;  4Z0L A;  3QH0 A;  3KCG L;  3ELA L;  5L2Z L;  4Z0K B;  1EPH A;  1HAF A;  1BF9 A;  2Y5F L;  5CKQ A;  1B9W A;  4NGA L;  4X8S L;  5IKQ A;  1NQL B;  3CEN L;  5I46 L;  4NG9 L;  2WYJ B;  1IJQ A;  2WPJ E;  2NPR A;  3SOQ A;  1XFE A;  1EMO A;  3MQE A;  1IGX A;  4BDX A;  1IOX A;  2H9E L;  2XC4 L;  2W86 A;  1UZQ A;  2W2Q E;  4XBM A;  5JW1 A;  4BXW A;  2I9B A;  1FJS L;  1F7M A;  3NTB A;  1CEJ A;  5K0H B;  1N7D A;  1EPJ A;  1MOX C;  3TGF A;  1DX5 I;  3CA7 A;  4Y7B B;  2YGQ A;  1NZI A;  2Y82 B;  1IQM L;  4ZH8 B;  4MMX B;  3HPT A;  4X8V L;  5JB9 E;  1UZP A;  2YGP A;  2P95 L;  2VWM K;  2EI6 B;  3BPS E;  3N8X A;  1ADX A;  2UWP B;  3LTG D;  2VH6 B;  4BXS A;  2F9B L;  3GCX E;  2WPL E;  1NT0 A;  4M11 A;  1ATE A;  3M37 L;  2AYL A;  1NPE B;  1IP0 A;  2BOK L;  1CX2 A;  2P3T A;  3DEM A;  2Y38 A;  4Z6A L;  2P93 L;  4ISI L;  2MGR A;  2J38 B;  5CKN A;  4YT7 L;  2W2P E;  2VWN L;  1UZK A;  2W3K B;  4ZXX L;  1AUT L;  1IQE L;  2W26 B;  1PXX A;  2P16 L;  1HAE A;  2J2U B;  1F0R B;  3POY A;  2OYE P;  1WHF A;  3MDL A;  2XC5 L;  2BOH A;  1HRF A;  3KRK A;  4COX A;  2D1J B;  1HX2 A;  1IOE L;  2W2N E;  5L30 L;  3FBY A;  1TLE A;  5E8D A;  3OLT A;  3LIW B;  4D0F A;  2Y81 B;  3BT2 A;  1EPG A;  2W3I B;  1J9C L;  5FDQ A;  2BO2 A;  4LMF A;  3NT1 A;  1JL9 A;  4Y76 B;  5CKM A;  3N8Y A;  1LMJ A;  1IQF L;  2P3U A;  4YT6 L;  2WPH E;  2VWL L;  4O02 B;  1P0S L;  2UWO B;  2PHB B;  1QFK L;  2VWO L;  4AQT A;  1DQB A;  5JB8 E;  4CUE A;  3HO5 A;  5KN5 C;  1APO A;  1Z6E L;  2JKH L;  3N8Z A;  5IKT A;  1APQ A;  2P3F N;  3FFG L;  2TGF A;  3V64 C;  1Q4G A;  4JZD L;  3HS5 A;  1UZJ A;  3F1S B;  1LQD A;  2I9A A;  4Y6D B;  2MGP A;  2XBX L;  3NTG A;  2Y5G L;  2P26 A;  6COX A;  1TPG A;  2GD4 A;  1COU A;  3P5B L;  1IGZ A;  4C16 A;  1EPI A;  3LC3 B;  4JZF L;  2DDU A;  3RR3 A;  1A3P A;  2XBW L;  2KNI A;  3GCW E;  1XKA L;  3Q3K B;  1GK5 A;  1P9J A;  1PGE A;  1U67 A;  1OB1 C;  2WFT A;  1IQG L;  3N8Y B;  3GIS X;  4BDW A;  3N8W A;  3IJE B;  2W2O E;  2YGO A;  1SZB A;  3SOB B;  1YUK B;  2FLR L;  2VVU L;  2UWL B;  1C5M F;  1XKB A;  2J95 B;  1L3Y A;  4JZE L;  1YUG A;  1HT8 A;  3LN0 A;  1KIG L;  3KK6 A;  2BQ6 A;  2WPK E;  4RRY A;  2XBV L;  4CUD A;  3QMO A;  1G1Q A;  3Q7D A;  3V65 B;  3TK5 B;  4BTI A;  1IQN L;  1CVW L;  1JV2 B;  2FLG A;  2XBY L;  4CUF A;  3PGH A;  4E1G A;  3U73 A;  3EGF A;  1ATB A;  1JBU L;  1HCG B;  2VH0 B;  1DVA L;  2VVV L;  1V3X B;  3ENS A;  4A7I A;  1NFX B;  3KQB L;  2EI8 B;  1YO8 A;  1K36 A;  1G2L B;  2WZP P;  3ZYG A;  3HS7 A;  2VJ3 A;  1O5D L;  4CSY A;  4RUT A;  4TGF A;  1EGF A;  1W7X L;  1CVU A;  4ZHA B;  1ATD A;  3N8W B;  1LPK A;  3CS7 L; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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