2W3KB

Crystal structure of fxa in complex with 4,4-disubstituted pyrrolidine-1,2-dicarboxamide inhibitor 1
Total Genus 11
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
11
sequence length
51
structure length
50
Chain Sequence
LCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTPYPCGKQTLE
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Exploration of 4,4-Disubstituted Pyrrolidine-1,2-Dicarboxamides as Potent, Orally Active Factor Xa Inhibitors with Extended Duration of Action.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords COAGULATION FACTOR X, HEAVY CHAIN
total genus 11
structure length 50
sequence length 51
ec nomenclature ec 3.4.21.6: Coagulation factor Xa.
pdb deposition date 2008-11-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF14670 FXa_inhibition Coagulation Factor Xa inhibitory site
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.25.10 Mainly Beta Ribbon Laminin Laminin 2w3kB00
2VVCK 1L5GB 3KQEL 2P3UA 1ATBA 3LC5B 3OLUA 5L2ZL 3N8YA 4Y71B 1PTHA 4YT7L 3ZYGA 1YUKB 4X8UL 3N8ZA 3Q3KB 1IQIL 4BTTA 2TGFA 1IJQA 2XC4L 1O5DL 2WPIE 1YUFA 1DVAL 2P95L 1IQML 2P93L 4LORA 1W8BL 2XC5L 1KIGL 1CVWL 3CFWA 3HS7A 3N8WB 4LMFA 3DEMA 4FM5A 3TZIA 1LPKA 2WPKE 2K2TA 1M1XB 4ISIL 3KRKA 2BQWA 1L3YA 4XL1A 1XKAL 4X8VL 2Y5GL 4COXA 1ADXA 2YGOA 2KV4A 2RNLA 1WHFA 1DIYA 2I9AA 1G1RA 2W2QE 4Z6AL 1KLJL 3FCSB 4CSYA 1G1QA 4Y79B 4BDWA 2BOXA 3U7UG 5F19A 1UZPA 2P16L 3TK6B 4JZEL 4O02B 2J94B 3QCWA 2WG3C 3U73A 3N8VA 4JZDL 3BPSE 1CQEA 1DDXA 1PFXL 5KN5C 1FJSL 2J34B 1NFUB 1EPJA 3ELAL 3P5BL 2BQ6A 3IITB 1Q4GA 1WHEA 2BOUA 1APOA 3LN1A 1EPGA 1TOZA 2PHBB 3ZYJB 1XFEA 4X8SL 2BOKL 1EMNA 2M74A 2P3FL 3FFGL 2VVUL 3GCXE 1ATEA 1UZQA 4AQTA 4MMZB 4JYUL 1UZJA 1HX2A 2BOHA 1CVUA 5CKQA 1FAKL 2W86A 2RHPA 4M11A 5CKMA 4TGFA 3LN0A 5KIRA 1OB1C 2W2NE 2VH0B 1V3XB 1NT0A 2UWLB 3CS7L 1EAIC 4G1MB 1I0UA 4MMXB 3KL6B 1XKBA 1HAEA 1SZBA 1LQDA 2VVVL 2Q1JB 2ADXA 1TPGA 2Y80B 1IQLL 4BXSA 2PR3B 2J2UB 1P0SL 1HREA 3PGHA 5E8DA 3N8WA 1K37A 4BXWA 2VWNL 3V65B 3LTFB 2XBVL 2NPRA 5CKNA 6COXA 2WFXB 1COUA 3M36L 2J4IB 2Y5FL 4ISHL 3GCWE 1MQ5L 3OLTA 3SOVA 1YUGA 4ZXYL 2H9EL 1ATDA 3M37L 4Y7BB 4CUFA 3GISX 2WPME 4JYVL 1MOXC 1DX5I 3NJPC 2YGPA 1HT5A 2EI8B 2FZZL 2DDUA 3BT2A 3HO3A 4E1GA 3LIWB 3NTBA 5IKVA 2XC0L 5L2YL 4NG9L 3POYA 1G1SA 4RRZA 2K2SB 1LMJA 4NGAL 5JB9E 1NQLB 1IGZA 2WG4B 5CISA 3KQBL 5JW1A 1GK5A 1CCVA 1CEJA 1Z6CA 4ZHAB 4D90A 1X7AL 5IKRA 2P26A 1BF9A 1B9WA 2RA0L 3TGFA 2D1JB 2FLRL 1JV2B 4Z0KB 2G00L 2WPLE 2BQ7A 3CENL 1CCFA 1F0RB 3NT1A 2W2PE 4MMYB 1EGFA 1APQA 2Y82B 1IOEL 4RRXA 4Z0LA 1HRFA 1N7DA 3ZYIB 4C16A 1FE2A 4ZAEB 1IQFL 5EGMB 1IOXA 1AUTL 2W3IB 2FLGA 1IQNL 3H5CB 1JBUL 4OTYA 4YT6L 2VWOL 1NFXB 1PGEA 3TH3L 2UWOB 3EGFA 1KSNB 3TBDA 3R05A 1XDTR 4O1ZA 1NFYB 2OYEP 4CUDA 1PRHA 2W26B 2J95B 2Y38A 1PXXA 2VH6B 3KK6A 2Y5HL 3QH0A 3IJEB 4ZH8B 2Y7ZB 4BTUA 4PH9A 1WU1B 4Y76B 5COXA 4ZXXL 4Y7AB 1HAFA 4JZFL 4XBMA 1G2LB 1EQGA 1IQGL 1IP0A 2EI7B 3ASIA 3MDLA 1IQEL 1IQHL 3HO4A 2Y81B 1EMOA 1LPGA 1U67A 3KQCL 1QFKL 2F9BL 1ZAQA 3KQDL 1F7MA 3CA7A 1CX2A 3NTGA 3HS6A 4RRYA 2FD6A 1C5MF 1MQ6L 2P3FN 4XLWA 2OYUP 2MGPA 2MHPA 2J38B 3SOBB 2BZ6L 4D0FA 1KLIL 1F7EA 1G2MB 5IKQA 1HCGB 1J9CL 1F0SB 1P9JA 2KB9A 1HT8A 3C9AC 1RFNB 4RRWA 3N8YB 5JBAE 1JL9A 2W2OE 3SOQA 2BO2A 4Y6DB 1U8CB 2VWMK 3LTGD 2WYGB 1YO8A 2VJ3A 5F1AA 2EI6B 1FF7A 3FBYA 1FFMA 1LPZA 5IKTA 2XBXL 5I46L 2MGRA 1IQKL 2XBYL 4D0EA 3F6UL 1DQBA 1FSBA 3BT1A 1IVOC 4RUTA 4BDXA 2BMGA 2GD4A 3LAQA 2XBWL 4X8TL 1ATAA 1G1TA 3ENSA 3RR3A 1A3PA 1N1IA 5L30L 4CUEA 2P28B 2P3TA 1TLEA 2B7DL 2WPJE 1EQHA 1HZ8A 1KLOA 3N8XA 3TK5B 1NPEB 4RS0A 5JVZA 1NFWB 4NA9L 1URKA 5JB8E 3V64C 1FAXL 1IGXA 1HJ7A 2FLBL 4M10A 1YGCL 2I9BA 2PUQL 4YZUB 2UWPB 5K0HB 2WYJB 2W3KB 3LC3B 5JBBE 2Y7XB 4BTIA 2P94L 2CJIB 3HS5A 3HPTA 1EPIA 3MQEA 2W2ME 1K36A 1EPHA 3Q7DA 3F1SB 1W7XL 3K9XA 5JVYA 5JBCE 3KCGL 2VWLL 3SW2A 1Z6EL 1UZKA 2KL7A 4A7IA 5FDQA 1NZIA 3QMOA 2WPHE 1EZQB 2WFTA 3HO5A 4OTJA 1IQJL 2AYLA 1EBVA 2JKHL
chains in the Genus database with same CATH superfamily
2VVCK 1L5GB 4GU3A 2HOXA 3KQEL 2P3UA 2KNIA 1ATBA 3LC5B 3OLUA 5L2ZL 3N8YA 4Y71B 1PTHA 4YT7L 3ZYGA 1YUKB 4X8UL 3N8ZA 3Q3KB 1IQIL 4BTTA 2TGFA 2WZPP 1IJQA 2XC4L 1O5DL 3S6XA 2WPIE 1YUFA 1DVAL 2P95L 1IQML 2P93L 4LORA 1W8BL 2XC5L 1KIGL 1CVWL 3CFWA 3HS7A 3N8WB 4LMFA 3DEMA 4FM5A 3TZIA 1LPKA 2WPKE 2K2TA 1M1XB 4ISIL 3KRKA 2BQWA 1L3YA 4XL1A 1XKAL 4X8VL 2Y5GL 4COXA 1ADXA 2YGOA 2KV4A 2RNLA 1WHFA 1DIYA 2I9AA 1G1RA 2BSFA 2W2QE 4Z6AL 1KLJL 3FCSB 4CSYA 1G1QA 4Y79B 4BDWA 2BOXA 3U7UG 5F19A 1UZPA 2P16L 3TK6B 4JZEL 4O02B 2J94B 3QCWA 2WG3C 3U73A 3N8VA 4JZDL 3BPSE 1CQEA 1V1HA 1DDXA 1PFXL 5KN5C 1FJSL 2J34B 1QIUA 1NFUB 1EPJA 3ELAL 3P5BL 2BQ6A 3IITB 1Q4GA 1WHEA 2BOUA 1APOA 3LN1A 1EPGA 1TOZA 2PHBB 3ZYJB 1XFEA 4X8SL 2BOKL 1EMNA 2M74A 2P3FL 3FFGL 2VVUL 3GCXE 1ATEA 1UZQA 4AQTA 4MMZB 4JYUL 1UZJA 1HX2A 2BOHA 1CVUA 5CKQA 1FAKL 2W86A 2RHPA 4M11A 5CKMA 4TGFA 3LN0A 5KIRA 1OB1C 2W2NE 2VH0B 1V3XB 1NT0A 2UWLB 3CS7L 1EAIC 4G1MB 1I0UA 4MMXB 3KL6B 1XKBA 1HAEA 1SZBA 1LQDA 2VVVL 2Q1JB 2ADXA 1TPGA 2Y80B 1IQLL 4BXSA 2PR3B 2YGQA 2J2UB 1P0SL 1HREA 2VRSA 3PGHA 5E8DA 3N8WA 1K37A 4BXWA 2VWNL 3V65B 3LTFB 2XBVL 2NPRA 5CKNA 6COXA 2WFXB 1COUA 3M36L 2J4IB 2Y5FL 4ISHL 3GCWE 1MQ5L 3OLTA 3SOVA 1YUGA 4ZXYL 2H9EL 1ATDA 3M37L 4Y7BB 4CUFA 3GISX 2WPME 4JYVL 1MOXC 1DX5I 3NJPC 2YGPA 4GU4A 1HT5A 2EI8B 2FZZL 2DDUA 3BT2A 3HO3A 4E1GA 3LIWB 3NTBA 5IKVA 2XC0L 5L2YL 4NG9L 3POYA 1G1SA 4RRZA 2K2SB 1LMJA 4NGAL 5JB9E 1NQLB 1IGZA 2WG4B 5CISA 3KQBL 1KKEA 5JW1A 1GK5A 1CCVA 1CEJA 1Z6CA 4ZHAB 4D90A 1X7AL 5IKRA 2P26A 1BF9A 1B9WA 2RA0L 3TGFA 2D1JB 2FLRL 1JV2B 4Z0KB 2G00L 2WPLE 2BQ7A 3CENL 1CCFA 1F0RB 3NT1A 2W2PE 4MMYB 1EGFA 1APQA 2Y82B 1IOEL 4RRXA 4Z0LA 1HRFA 1N7DA 3ZYIB 4C16A 1FE2A 1LK9A 1IQFL 4ZAEB 5EGMB 1IOXA 2H9EC 1AUTL 2W3IB 2FLGA 1IQNL 3H5CB 1JBUL 4OTYA 4YT6L 2VWOL 1NFXB 1PGEA 3TH3L 2UWOB 3EGFA 1KSNB 3TBDA 3R05A 1XDTR 4O1ZA 1NFYB 2OYEP 4CUDA 1PRHA 2W26B 2J95B 2Y38A 1PXXA 2VH6B 3KK6A 2Y5HL 3QH0A 3IJEB 4ZH8B 2Y7ZB 4BTUA 4PH9A 1WU1B 4Y76B 5COXA 4ZXXL 4Y7AB 1HAFA 4JZFL 4XBMA 1G2LB 1EQGA 1IQGL 1IP0A 2EI7B 3ASIA 3MDLA 2BT7A 1IQEL 1IQHL 3HO4A 2Y81B 1EMOA 1LPGA 1U67A 3KQCL 1QFKL 2F9BL 1ZAQA 3KQDL 1F7MA 3CA7A 1CX2A 3NTGA 3HS6A 4RRYA 2FD6A 1C5MF 1MQ6L 2P3FN 4XLWA 2OYUP 2MGPA 2MHPA 2J38B 3SOBB 2BZ6L 4D0FA 1KLIL 1F7EA 1G2MB 5IKQA 1HCGB 1J9CL 1F0SB 1P9JA 2KB9A 1HT8A 3C9AC 1RFNB 4RRWA 3N8YB 5JBAE 1JL9A 2W2OE 3SOQA 2BO2A 4Y6DB 1U8CB 2VWMK 3LTGD 2WYGB 2JJLA 1YO8A 2VJ3A 5F1AA 2EI6B 1FF7A 3FBYA 1FFMA 1LPZA 5IKTA 2XBXL 5I46L 2MGRA 1IQKL 2XBYL 4D0EA 3F6UL 1DQBA 1FSBA 3BT1A 1IVOC 4RUTA 4BDXA 2BT8A 2BMGA 2GD4A 3LAQA 2XBWL 4X8TL 1ATAA 1G1TA 3ENSA 3RR3A 1A3PA 1N1IA 5L30L 4CUEA 2P28B 2P3TA 4A94C 1TLEA 2B7DL 2WPJE 1EQHA 1HZ8A 1KLOA 3N8XA 3TK5B 1NPEB 4RS0A 5JVZA 1NFWB 4NA9L 1URKA 5JB8E 3V64C 1FAXL 1IGXA 1HJ7A 2FLBL 2HORA 4M10A 1V1IA 1YGCL 2I9BA 2PUQL 4YZUB 2UWPB 5K0HB 2WYJB 2W3KB 3LC3B 5JBBE 2Y7XB 4BTIA 2P94L 2CJIB 3HS5A 3HPTA 1EPIA 3MQEA 2W2ME 1K36A 1EPHA 3Q7DA 3F1SB 1W7XL 3K9XA 5JVYA 5JBCE 3KCGL 2VWLL 3SW2A 1Z6EL 1UZKA 2KL7A 4A7IA 5FDQA 1NZIA 3QMOA 2WPHE 1EZQB 2WFTA 3HO5A 4OTJA 1IQJL 1LMMA 2AYLA 1EBVA 2JKHL
chains in the Genus database with same CATH topology
2VVCK 1L5GB 3KQEL 2P3UA 2KNIA 1ATBA 3LC5B 3OLUA 5L2ZL 3N8YA 4Y71B 1PTHA 4YT7L 3ZYGA 1YUKB 4X8UL 3N8ZA 3Q3KB 1IQIL 4BTTA 2TGFA 2WZPP 1IJQA 2XC4L 1O5DL 3S6XA 2WPIE 1YUFA 1DVAL 2P95L 1IQML 2P93L 4LORA 1W8BL 2XC5L 1KIGL 1CVWL 3CFWA 3HS7A 3N8WB 4LMFA 3DEMA 4FM5A 3TZIA 1LPKA 2WPKE 2K2TA 1M1XB 4ISIL 3KRKA 2BQWA 1L3YA 4XL1A 1XKAL 4X8VL 2Y5GL 4COXA 1ADXA 2YGOA 2KV4A 2RNLA 1WHFA 1DIYA 2I9AA 1G1RA 2W2QE 4Z6AL 1KLJL 3FCSB 4CSYA 1G1QA 4Y79B 4BDWA 2BOXA 3U7UG 5F19A 1UZPA 2P16L 3TK6B 4JZEL 4O02B 2J94B 3QCWA 2WG3C 3U73A 3N8VA 4JZDL 3BPSE 1CQEA 1DDXA 1PFXL 5KN5C 1FJSL 2J34B 1NFUB 1EPJA 3ELAL 3P5BL 2BQ6A 3IITB 1Q4GA 1WHEA 2BOUA 1APOA 3LN1A 1EPGA 1TOZA 2PHBB 3ZYJB 1XFEA 4X8SL 2BOKL 1EMNA 2M74A 2P3FL 3FFGL 2VVUL 3GCXE 1ATEA 1UZQA 4AQTA 4MMZB 4JYUL 1UZJA 1HX2A 2BOHA 1CVUA 5CKQA 1FAKL 2W86A 2RHPA 4M11A 5CKMA 4TGFA 3LN0A 5KIRA 1OB1C 2W2NE 2VH0B 1V3XB 1NT0A 2UWLB 3CS7L 1EAIC 4G1MB 1I0UA 4MMXB 3KL6B 1XKBA 1HAEA 1SZBA 1LQDA 2VVVL 2Q1JB 2ADXA 1TPGA 2Y80B 1IQLL 4BXSA 2PR3B 2YGQA 2J2UB 1P0SL 1HREA 3PGHA 5E8DA 3N8WA 1K37A 4BXWA 2VWNL 3V65B 3LTFB 2XBVL 2NPRA 5CKNA 6COXA 2WFXB 1COUA 3M36L 2J4IB 2Y5FL 4ISHL 3GCWE 1MQ5L 3OLTA 3SOVA 1YUGA 4ZXYL 2H9EL 1ATDA 3M37L 4Y7BB 4CUFA 3GISX 2WPME 4JYVL 1MOXC 1DX5I 3NJPC 2YGPA 1HT5A 2EI8B 2FZZL 2DDUA 3BT2A 3HO3A 4E1GA 3LIWB 3NTBA 5IKVA 2XC0L 5L2YL 4NG9L 3POYA 1G1SA 4RRZA 2K2SB 1LMJA 4NGAL 5JB9E 1NQLB 1IGZA 2WG4B 5CISA 3KQBL 5JW1A 1GK5A 1CCVA 1CEJA 1Z6CA 4ZHAB 4D90A 1X7AL 5IKRA 2P26A 1BF9A 1B9WA 2RA0L 3TGFA 2D1JB 2FLRL 1JV2B 4Z0KB 2G00L 2WPLE 2BQ7A 3CENL 1CCFA 1F0RB 3NT1A 2W2PE 4MMYB 1EGFA 1APQA 2Y82B 1IOEL 4RRXA 4Z0LA 1HRFA 1N7DA 3ZYIB 4C16A 1FE2A 4ZAEB 1IQFL 5EGMB 1IOXA 2H9EC 1AUTL 2W3IB 2FLGA 1IQNL 3H5CB 1JBUL 4OTYA 4YT6L 2VWOL 1NFXB 1PGEA 3TH3L 2UWOB 3EGFA 1KSNB 3TBDA 3R05A 1XDTR 4O1ZA 1NFYB 2OYEP 4CUDA 1PRHA 2W26B 2J95B 2Y38A 1PXXA 2VH6B 3KK6A 2Y5HL 3QH0A 3IJEB 4ZH8B 2Y7ZB 4BTUA 4PH9A 1WU1B 4Y76B 5COXA 4ZXXL 4Y7AB 1HAFA 4JZFL 4XBMA 1G2LB 1EQGA 1IQGL 1IP0A 2EI7B 3ASIA 3MDLA 1IQEL 1IQHL 3HO4A 2Y81B 1EMOA 1LPGA 1U67A 3KQCL 1QFKL 2F9BL 1ZAQA 3KQDL 1F7MA 3CA7A 1CX2A 3NTGA 3HS6A 4RRYA 2FD6A 1C5MF 1MQ6L 2P3FN 4XLWA 2OYUP 2MGPA 2MHPA 2J38B 3SOBB 2BZ6L 4D0FA 1KLIL 1F7EA 1G2MB 5IKQA 1HCGB 1J9CL 1F0SB 1P9JA 2KB9A 1HT8A 3C9AC 1RFNB 4RRWA 3N8YB 5JBAE 1JL9A 2W2OE 3SOQA 2BO2A 4Y6DB 1U8CB 2VWMK 3LTGD 2WYGB 1YO8A 2VJ3A 5F1AA 2EI6B 1FF7A 3FBYA 1FFMA 1LPZA 5IKTA 2XBXL 5I46L 2MGRA 1IQKL 2XBYL 4D0EA 3F6UL 1DQBA 1FSBA 3BT1A 1IVOC 4RUTA 4BDXA 2BMGA 2GD4A 3LAQA 2XBWL 4X8TL 1ATAA 1G1TA 3ENSA 3RR3A 1A3PA 1N1IA 5L30L 4CUEA 2P28B 2P3TA 4A94C 1TLEA 2B7DL 2WPJE 1EQHA 1HZ8A 1KLOA 3N8XA 3TK5B 1NPEB 4RS0A 5JVZA 1NFWB 4NA9L 1URKA 5JB8E 3V64C 1FAXL 1IGXA 1HJ7A 2FLBL 4M10A 1YGCL 2I9BA 2PUQL 4YZUB 2UWPB 5K0HB 2WYJB 2W3KB 3LC3B 5JBBE 2Y7XB 4BTIA 2P94L 2CJIB 3HS5A 3HPTA 1EPIA 3MQEA 2W2ME 1K36A 1EPHA 3Q7DA 3F1SB 1W7XL 3K9XA 5JVYA 5JBCE 3KCGL 2VWLL 3SW2A 1Z6EL 1UZKA 2KL7A 4A7IA 5FDQA 1NZIA 3QMOA 2WPHE 1EZQB 2WFTA 3HO5A 4OTJA 1IQJL 1LMMA 2AYLA 1EBVA 2JKHL
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2VVC K;  1L5G B;  3KQE L;  2P3U A;  1ATB A;  3LC5 B;  3OLU A;  5L2Z L;  3N8Y A;  4Y71 B;  1PTH A;  4YT7 L;  3ZYG A;  1YUK B;  4X8U L;  3N8Z A;  3Q3K B;  1IQI L;  4BTT A;  2TGF A;  1IJQ A;  2XC4 L;  1O5D L;  2WPI E;  1YUF A;  1DVA L;  2P95 L;  1IQM L;  2P93 L;  4LOR A;  1W8B L;  2XC5 L;  1KIG L;  1CVW L;  3CFW A;  3HS7 A;  3N8W B;  4LMF A;  3DEM A;  4FM5 A;  3TZI A;  1LPK A;  2WPK E;  2K2T A;  1M1X B;  4ISI L;  3KRK A;  2BQW A;  1L3Y A;  4XL1 A;  1XKA L;  4X8V L;  2Y5G L;  4COX A;  1ADX A;  2YGO A;  2KV4 A;  2RNL A;  1WHF A;  1DIY A;  2I9A A;  1G1R A;  2W2Q E;  4Z6A L;  1KLJ L;  3FCS B;  4CSY A;  1G1Q A;  4Y79 B;  4BDW A;  2BOX A;  3U7U G;  5F19 A;  1UZP A;  2P16 L;  3TK6 B;  4JZE L;  4O02 B;  2J94 B;  3QCW A;  2WG3 C;  3U73 A;  3N8V A;  4JZD L;  3BPS E;  1CQE A;  1DDX A;  1PFX L;  5KN5 C;  1FJS L;  2J34 B;  1NFU B;  1EPJ A;  3ELA L;  3P5B L;  2BQ6 A;  3IIT B;  1Q4G A;  1WHE A;  2BOU A;  1APO A;  3LN1 A;  1EPG A;  1TOZ A;  2PHB B;  3ZYJ B;  1XFE A;  4X8S L;  2BOK L;  1EMN A;  2M74 A;  2P3F L;  3FFG L;  2VVU L;  3GCX E;  1ATE A;  1UZQ A;  4AQT A;  4MMZ B;  4JYU L;  1UZJ A;  1HX2 A;  2BOH A;  1CVU A;  5CKQ A;  1FAK L;  2W86 A;  2RHP A;  4M11 A;  5CKM A;  4TGF A;  3LN0 A;  5KIR A;  1OB1 C;  2W2N E;  2VH0 B;  1V3X B;  1NT0 A;  2UWL B;  3CS7 L;  1EAI C;  4G1M B;  1I0U A;  4MMX B;  3KL6 B;  1XKB A;  1HAE A;  1SZB A;  1LQD A;  2VVV L;  2Q1J B;  2ADX A;  1TPG A;  2Y80 B;  1IQL L;  4BXS A;  2PR3 B;  2J2U B;  1P0S L;  1HRE A;  3PGH A;  5E8D A;  3N8W A;  1K37 A;  4BXW A;  2VWN L;  3V65 B;  3LTF B;  2XBV L;  2NPR A;  5CKN A;  6COX A;  2WFX B;  1COU A;  3M36 L;  2J4I B;  2Y5F L;  4ISH L;  3GCW E;  1MQ5 L;  3OLT A;  3SOV A;  1YUG A;  4ZXY L;  2H9E L;  1ATD A;  3M37 L;  4Y7B B;  4CUF A;  3GIS X;  2WPM E;  4JYV L;  1MOX C;  1DX5 I;  3NJP C;  2YGP A;  1HT5 A;  2EI8 B;  2FZZ L;  2DDU A;  3BT2 A;  3HO3 A;  4E1G A;  3LIW B;  3NTB A;  5IKV A;  2XC0 L;  5L2Y L;  4NG9 L;  3POY A;  1G1S A;  4RRZ A;  2K2S B;  1LMJ A;  4NGA L;  5JB9 E;  1NQL B;  1IGZ A;  2WG4 B;  5CIS A;  3KQB L;  5JW1 A;  1GK5 A;  1CCV A;  1CEJ A;  1Z6C A;  4ZHA B;  4D90 A;  1X7A L;  5IKR A;  2P26 A;  1BF9 A;  1B9W A;  2RA0 L;  3TGF A;  2D1J B;  2FLR L;  1JV2 B;  4Z0K B;  2G00 L;  2WPL E;  2BQ7 A;  3CEN L;  1CCF A;  1F0R B;  3NT1 A;  2W2P E;  4MMY B;  1EGF A;  1APQ A;  2Y82 B;  1IOE L;  4RRX A;  4Z0L A;  1HRF A;  1N7D A;  3ZYI B;  4C16 A;  1FE2 A;  4ZAE B;  1IQF L;  5EGM B;  1IOX A;  1AUT L;  2W3I B;  2FLG A;  1IQN L;  3H5C B;  1JBU L;  4OTY A;  4YT6 L;  2VWO L;  1NFX B;  1PGE A;  3TH3 L;  2UWO B;  3EGF A;  1KSN B;  3TBD A;  3R05 A;  1XDT R;  4O1Z A;  1NFY B;  2OYE P;  4CUD A;  1PRH A;  2W26 B;  2J95 B;  2Y38 A;  1PXX A;  2VH6 B;  3KK6 A;  2Y5H L;  3QH0 A;  3IJE B;  4ZH8 B;  2Y7Z B;  4BTU A;  4PH9 A;  1WU1 B;  4Y76 B;  5COX A;  4ZXX L;  4Y7A B;  1HAF A;  4JZF L;  4XBM A;  1G2L B;  1EQG A;  1IQG L;  1IP0 A;  2EI7 B;  3ASI A;  3MDL A;  1IQE L;  1IQH L;  3HO4 A;  2Y81 B;  1EMO A;  1LPG A;  1U67 A;  3KQC L;  1QFK L;  2F9B L;  1ZAQ A;  3KQD L;  1F7M A;  3CA7 A;  1CX2 A;  3NTG A;  3HS6 A;  4RRY A;  2FD6 A;  1C5M F;  1MQ6 L;  2P3F N;  4XLW A;  2OYU P;  2MGP A;  2MHP A;  2J38 B;  3SOB B;  2BZ6 L;  4D0F A;  1KLI L;  1F7E A;  1G2M B;  5IKQ A;  1HCG B;  1J9C L;  1F0S B;  1P9J A;  2KB9 A;  1HT8 A;  3C9A C;  1RFN B;  4RRW A;  3N8Y B;  5JBA E;  1JL9 A;  2W2O E;  3SOQ A;  2BO2 A;  4Y6D B;  1U8C B;  2VWM K;  3LTG D;  2WYG B;  1YO8 A;  2VJ3 A;  5F1A A;  2EI6 B;  1FF7 A;  3FBY A;  1FFM A;  1LPZ A;  5IKT A;  2XBX L;  5I46 L;  2MGR A;  1IQK L;  2XBY L;  4D0E A;  3F6U L;  1DQB A;  1FSB A;  3BT1 A;  1IVO C;  4RUT A;  4BDX A;  2BMG A;  2GD4 A;  3LAQ A;  2XBW L;  4X8T L;  1ATA A;  1G1T A;  3ENS A;  3RR3 A;  1A3P A;  1N1I A;  5L30 L;  4CUE A;  2P28 B;  2P3T A;  1TLE A;  2B7D L;  2WPJ E;  1EQH A;  1HZ8 A;  1KLO A;  3N8X A;  3TK5 B;  1NPE B;  4RS0 A;  5JVZ A;  1NFW B;  4NA9 L;  1URK A;  5JB8 E;  3V64 C;  1FAX L;  1IGX A;  1HJ7 A;  2FLB L;  4M10 A;  1YGC L;  2I9B A;  2PUQ L;  4YZU B;  2UWP B;  5K0H B;  2WYJ B;  2W3K B;  3LC3 B;  5JBB E;  2Y7X B;  4BTI A;  2P94 L;  2CJI B;  3HS5 A;  3HPT A;  1EPI A;  3MQE A;  2W2M E;  1K36 A;  1EPH A;  3Q7D A;  3F1S B;  1W7X L;  3K9X A;  5JVY A;  5JBC E;  3KCG L;  2VWL L;  3SW2 A;  1Z6E L;  1UZK A;  2KL7 A;  4A7I A;  5FDQ A;  1NZI A;  3QMO A;  2WPH E;  1EZQ B;  2WFT A;  3HO5 A;  4OTJ A;  1IQJ L;  2AYL A;  1EBV A;  2JKH L; 
#chains in the Genus database with same CATH topology
 2VVC K;  1L5G B;  4GU3 A;  2HOX A;  3KQE L;  2P3U A;  2KNI A;  1ATB A;  3LC5 B;  3OLU A;  5L2Z L;  3N8Y A;  4Y71 B;  1PTH A;  4YT7 L;  3ZYG A;  1YUK B;  4X8U L;  3N8Z A;  3Q3K B;  1IQI L;  4BTT A;  2TGF A;  2WZP P;  1IJQ A;  2XC4 L;  1O5D L;  3S6X A;  2WPI E;  1YUF A;  1DVA L;  2P95 L;  1IQM L;  2P93 L;  4LOR A;  1W8B L;  2XC5 L;  1KIG L;  1CVW L;  3CFW A;  3HS7 A;  3N8W B;  4LMF A;  3DEM A;  4FM5 A;  3TZI A;  1LPK A;  2WPK E;  2K2T A;  1M1X B;  4ISI L;  3KRK A;  2BQW A;  1L3Y A;  4XL1 A;  1XKA L;  4X8V L;  2Y5G L;  4COX A;  1ADX A;  2YGO A;  2KV4 A;  2RNL A;  1WHF A;  1DIY A;  2I9A A;  1G1R A;  2BSF A;  2W2Q E;  4Z6A L;  1KLJ L;  3FCS B;  4CSY A;  1G1Q A;  4Y79 B;  4BDW A;  2BOX A;  3U7U G;  5F19 A;  1UZP A;  2P16 L;  3TK6 B;  4JZE L;  4O02 B;  2J94 B;  3QCW A;  2WG3 C;  3U73 A;  3N8V A;  4JZD L;  3BPS E;  1CQE A;  1V1H A;  1DDX A;  1PFX L;  5KN5 C;  1FJS L;  2J34 B;  1QIU A;  1NFU B;  1EPJ A;  3ELA L;  3P5B L;  2BQ6 A;  3IIT B;  1Q4G A;  1WHE A;  2BOU A;  1APO A;  3LN1 A;  1EPG A;  1TOZ A;  2PHB B;  3ZYJ B;  1XFE A;  4X8S L;  2BOK L;  1EMN A;  2M74 A;  2P3F L;  3FFG L;  2VVU L;  3GCX E;  1ATE A;  1UZQ A;  4AQT A;  4MMZ B;  4JYU L;  1UZJ A;  1HX2 A;  2BOH A;  1CVU A;  5CKQ A;  1FAK L;  2W86 A;  2RHP A;  4M11 A;  5CKM A;  4TGF A;  3LN0 A;  5KIR A;  1OB1 C;  2W2N E;  2VH0 B;  1V3X B;  1NT0 A;  2UWL B;  3CS7 L;  1EAI C;  4G1M B;  1I0U A;  4MMX B;  3KL6 B;  1XKB A;  1HAE A;  1SZB A;  1LQD A;  2VVV L;  2Q1J B;  2ADX A;  1TPG A;  2Y80 B;  1IQL L;  4BXS A;  2PR3 B;  2YGQ A;  2J2U B;  1P0S L;  1HRE A;  2VRS A;  3PGH A;  5E8D A;  3N8W A;  1K37 A;  4BXW A;  2VWN L;  3V65 B;  3LTF B;  2XBV L;  2NPR A;  5CKN A;  6COX A;  2WFX B;  1COU A;  3M36 L;  2J4I B;  2Y5F L;  4ISH L;  3GCW E;  1MQ5 L;  3OLT A;  3SOV A;  1YUG A;  4ZXY L;  2H9E L;  1ATD A;  3M37 L;  4Y7B B;  4CUF A;  3GIS X;  2WPM E;  4JYV L;  1MOX C;  1DX5 I;  3NJP C;  2YGP A;  4GU4 A;  1HT5 A;  2EI8 B;  2FZZ L;  2DDU A;  3BT2 A;  3HO3 A;  4E1G A;  3LIW B;  3NTB A;  5IKV A;  2XC0 L;  5L2Y L;  4NG9 L;  3POY A;  1G1S A;  4RRZ A;  2K2S B;  1LMJ A;  4NGA L;  5JB9 E;  1NQL B;  1IGZ A;  2WG4 B;  5CIS A;  3KQB L;  1KKE A;  5JW1 A;  1GK5 A;  1CCV A;  1CEJ A;  1Z6C A;  4ZHA B;  4D90 A;  1X7A L;  5IKR A;  2P26 A;  1BF9 A;  1B9W A;  2RA0 L;  3TGF A;  2D1J B;  2FLR L;  1JV2 B;  4Z0K B;  2G00 L;  2WPL E;  2BQ7 A;  3CEN L;  1CCF A;  1F0R B;  3NT1 A;  2W2P E;  4MMY B;  1EGF A;  1APQ A;  2Y82 B;  1IOE L;  4RRX A;  4Z0L A;  1HRF A;  1N7D A;  3ZYI B;  4C16 A;  1FE2 A;  1LK9 A;  1IQF L;  4ZAE B;  5EGM B;  1IOX A;  2H9E C;  1AUT L;  2W3I B;  2FLG A;  1IQN L;  3H5C B;  1JBU L;  4OTY A;  4YT6 L;  2VWO L;  1NFX B;  1PGE A;  3TH3 L;  2UWO B;  3EGF A;  1KSN B;  3TBD A;  3R05 A;  1XDT R;  4O1Z A;  1NFY B;  2OYE P;  4CUD A;  1PRH A;  2W26 B;  2J95 B;  2Y38 A;  1PXX A;  2VH6 B;  3KK6 A;  2Y5H L;  3QH0 A;  3IJE B;  4ZH8 B;  2Y7Z B;  4BTU A;  4PH9 A;  1WU1 B;  4Y76 B;  5COX A;  4ZXX L;  4Y7A B;  1HAF A;  4JZF L;  4XBM A;  1G2L B;  1EQG A;  1IQG L;  1IP0 A;  2EI7 B;  3ASI A;  3MDL A;  2BT7 A;  1IQE L;  1IQH L;  3HO4 A;  2Y81 B;  1EMO A;  1LPG A;  1U67 A;  3KQC L;  1QFK L;  2F9B L;  1ZAQ A;  3KQD L;  1F7M A;  3CA7 A;  1CX2 A;  3NTG A;  3HS6 A;  4RRY A;  2FD6 A;  1C5M F;  1MQ6 L;  2P3F N;  4XLW A;  2OYU P;  2MGP A;  2MHP A;  2J38 B;  3SOB B;  2BZ6 L;  4D0F A;  1KLI L;  1F7E A;  1G2M B;  5IKQ A;  1HCG B;  1J9C L;  1F0S B;  1P9J A;  2KB9 A;  1HT8 A;  3C9A C;  1RFN B;  4RRW A;  3N8Y B;  5JBA E;  1JL9 A;  2W2O E;  3SOQ A;  2BO2 A;  4Y6D B;  1U8C B;  2VWM K;  3LTG D;  2WYG B;  2JJL A;  1YO8 A;  2VJ3 A;  5F1A A;  2EI6 B;  1FF7 A;  3FBY A;  1FFM A;  1LPZ A;  5IKT A;  2XBX L;  5I46 L;  2MGR A;  1IQK L;  2XBY L;  4D0E A;  3F6U L;  1DQB A;  1FSB A;  3BT1 A;  1IVO C;  4RUT A;  4BDX A;  2BT8 A;  2BMG A;  2GD4 A;  3LAQ A;  2XBW L;  4X8T L;  1ATA A;  1G1T A;  3ENS A;  3RR3 A;  1A3P A;  1N1I A;  5L30 L;  4CUE A;  2P28 B;  2P3T A;  4A94 C;  1TLE A;  2B7D L;  2WPJ E;  1EQH A;  1HZ8 A;  1KLO A;  3N8X A;  3TK5 B;  1NPE B;  4RS0 A;  5JVZ A;  1NFW B;  4NA9 L;  1URK A;  5JB8 E;  3V64 C;  1FAX L;  1IGX A;  1HJ7 A;  2FLB L;  2HOR A;  4M10 A;  1V1I A;  1YGC L;  2I9B A;  2PUQ L;  4YZU B;  2UWP B;  5K0H B;  2WYJ B;  2W3K B;  3LC3 B;  5JBB E;  2Y7X B;  4BTI A;  2P94 L;  2CJI B;  3HS5 A;  3HPT A;  1EPI A;  3MQE A;  2W2M E;  1K36 A;  1EPH A;  3Q7D A;  3F1S B;  1W7X L;  3K9X A;  5JVY A;  5JBC E;  3KCG L;  2VWL L;  3SW2 A;  1Z6E L;  1UZK A;  2KL7 A;  4A7I A;  5FDQ A;  1NZI A;  3QMO A;  2WPH E;  1EZQ B;  2WFT A;  3HO5 A;  4OTJ A;  1IQJ L;  1LMM A;  2AYL A;  1EBV A;  2JKH L; 
#chains in the Genus database with same CATH homology
 2VVC K;  1L5G B;  3KQE L;  2P3U A;  2KNI A;  1ATB A;  3LC5 B;  3OLU A;  5L2Z L;  3N8Y A;  4Y71 B;  1PTH A;  4YT7 L;  3ZYG A;  1YUK B;  4X8U L;  3N8Z A;  3Q3K B;  1IQI L;  4BTT A;  2TGF A;  2WZP P;  1IJQ A;  2XC4 L;  1O5D L;  3S6X A;  2WPI E;  1YUF A;  1DVA L;  2P95 L;  1IQM L;  2P93 L;  4LOR A;  1W8B L;  2XC5 L;  1KIG L;  1CVW L;  3CFW A;  3HS7 A;  3N8W B;  4LMF A;  3DEM A;  4FM5 A;  3TZI A;  1LPK A;  2WPK E;  2K2T A;  1M1X B;  4ISI L;  3KRK A;  2BQW A;  1L3Y A;  4XL1 A;  1XKA L;  4X8V L;  2Y5G L;  4COX A;  1ADX A;  2YGO A;  2KV4 A;  2RNL A;  1WHF A;  1DIY A;  2I9A A;  1G1R A;  2W2Q E;  4Z6A L;  1KLJ L;  3FCS B;  4CSY A;  1G1Q A;  4Y79 B;  4BDW A;  2BOX A;  3U7U G;  5F19 A;  1UZP A;  2P16 L;  3TK6 B;  4JZE L;  4O02 B;  2J94 B;  3QCW A;  2WG3 C;  3U73 A;  3N8V A;  4JZD L;  3BPS E;  1CQE A;  1DDX A;  1PFX L;  5KN5 C;  1FJS L;  2J34 B;  1NFU B;  1EPJ A;  3ELA L;  3P5B L;  2BQ6 A;  3IIT B;  1Q4G A;  1WHE A;  2BOU A;  1APO A;  3LN1 A;  1EPG A;  1TOZ A;  2PHB B;  3ZYJ B;  1XFE A;  4X8S L;  2BOK L;  1EMN A;  2M74 A;  2P3F L;  3FFG L;  2VVU L;  3GCX E;  1ATE A;  1UZQ A;  4AQT A;  4MMZ B;  4JYU L;  1UZJ A;  1HX2 A;  2BOH A;  1CVU A;  5CKQ A;  1FAK L;  2W86 A;  2RHP A;  4M11 A;  5CKM A;  4TGF A;  3LN0 A;  5KIR A;  1OB1 C;  2W2N E;  2VH0 B;  1V3X B;  1NT0 A;  2UWL B;  3CS7 L;  1EAI C;  4G1M B;  1I0U A;  4MMX B;  3KL6 B;  1XKB A;  1HAE A;  1SZB A;  1LQD A;  2VVV L;  2Q1J B;  2ADX A;  1TPG A;  2Y80 B;  1IQL L;  4BXS A;  2PR3 B;  2YGQ A;  2J2U B;  1P0S L;  1HRE A;  3PGH A;  5E8D A;  3N8W A;  1K37 A;  4BXW A;  2VWN L;  3V65 B;  3LTF B;  2XBV L;  2NPR A;  5CKN A;  6COX A;  2WFX B;  1COU A;  3M36 L;  2J4I B;  2Y5F L;  4ISH L;  3GCW E;  1MQ5 L;  3OLT A;  3SOV A;  1YUG A;  4ZXY L;  2H9E L;  1ATD A;  3M37 L;  4Y7B B;  4CUF A;  3GIS X;  2WPM E;  4JYV L;  1MOX C;  1DX5 I;  3NJP C;  2YGP A;  1HT5 A;  2EI8 B;  2FZZ L;  2DDU A;  3BT2 A;  3HO3 A;  4E1G A;  3LIW B;  3NTB A;  5IKV A;  2XC0 L;  5L2Y L;  4NG9 L;  3POY A;  1G1S A;  4RRZ A;  2K2S B;  1LMJ A;  4NGA L;  5JB9 E;  1NQL B;  1IGZ A;  2WG4 B;  5CIS A;  3KQB L;  5JW1 A;  1GK5 A;  1CCV A;  1CEJ A;  1Z6C A;  4ZHA B;  4D90 A;  1X7A L;  5IKR A;  2P26 A;  1BF9 A;  1B9W A;  2RA0 L;  3TGF A;  2D1J B;  2FLR L;  1JV2 B;  4Z0K B;  2G00 L;  2WPL E;  2BQ7 A;  3CEN L;  1CCF A;  1F0R B;  3NT1 A;  2W2P E;  4MMY B;  1EGF A;  1APQ A;  2Y82 B;  1IOE L;  4RRX A;  4Z0L A;  1HRF A;  1N7D A;  3ZYI B;  4C16 A;  1FE2 A;  4ZAE B;  1IQF L;  5EGM B;  1IOX A;  2H9E C;  1AUT L;  2W3I B;  2FLG A;  1IQN L;  3H5C B;  1JBU L;  4OTY A;  4YT6 L;  2VWO L;  1NFX B;  1PGE A;  3TH3 L;  2UWO B;  3EGF A;  1KSN B;  3TBD A;  3R05 A;  1XDT R;  4O1Z A;  1NFY B;  2OYE P;  4CUD A;  1PRH A;  2W26 B;  2J95 B;  2Y38 A;  1PXX A;  2VH6 B;  3KK6 A;  2Y5H L;  3QH0 A;  3IJE B;  4ZH8 B;  2Y7Z B;  4BTU A;  4PH9 A;  1WU1 B;  4Y76 B;  5COX A;  4ZXX L;  4Y7A B;  1HAF A;  4JZF L;  4XBM A;  1G2L B;  1EQG A;  1IQG L;  1IP0 A;  2EI7 B;  3ASI A;  3MDL A;  1IQE L;  1IQH L;  3HO4 A;  2Y81 B;  1EMO A;  1LPG A;  1U67 A;  3KQC L;  1QFK L;  2F9B L;  1ZAQ A;  3KQD L;  1F7M A;  3CA7 A;  1CX2 A;  3NTG A;  3HS6 A;  4RRY A;  2FD6 A;  1C5M F;  1MQ6 L;  2P3F N;  4XLW A;  2OYU P;  2MGP A;  2MHP A;  2J38 B;  3SOB B;  2BZ6 L;  4D0F A;  1KLI L;  1F7E A;  1G2M B;  5IKQ A;  1HCG B;  1J9C L;  1F0S B;  1P9J A;  2KB9 A;  1HT8 A;  3C9A C;  1RFN B;  4RRW A;  3N8Y B;  5JBA E;  1JL9 A;  2W2O E;  3SOQ A;  2BO2 A;  4Y6D B;  1U8C B;  2VWM K;  3LTG D;  2WYG B;  1YO8 A;  2VJ3 A;  5F1A A;  2EI6 B;  1FF7 A;  3FBY A;  1FFM A;  1LPZ A;  5IKT A;  2XBX L;  5I46 L;  2MGR A;  1IQK L;  2XBY L;  4D0E A;  3F6U L;  1DQB A;  1FSB A;  3BT1 A;  1IVO C;  4RUT A;  4BDX A;  2BMG A;  2GD4 A;  3LAQ A;  2XBW L;  4X8T L;  1ATA A;  1G1T A;  3ENS A;  3RR3 A;  1A3P A;  1N1I A;  5L30 L;  4CUE A;  2P28 B;  2P3T A;  4A94 C;  1TLE A;  2B7D L;  2WPJ E;  1EQH A;  1HZ8 A;  1KLO A;  3N8X A;  3TK5 B;  1NPE B;  4RS0 A;  5JVZ A;  1NFW B;  4NA9 L;  1URK A;  5JB8 E;  3V64 C;  1FAX L;  1IGX A;  1HJ7 A;  2FLB L;  4M10 A;  1YGC L;  2I9B A;  2PUQ L;  4YZU B;  2UWP B;  5K0H B;  2WYJ B;  2W3K B;  3LC3 B;  5JBB E;  2Y7X B;  4BTI A;  2P94 L;  2CJI B;  3HS5 A;  3HPT A;  1EPI A;  3MQE A;  2W2M E;  1K36 A;  1EPH A;  3Q7D A;  3F1S B;  1W7X L;  3K9X A;  5JVY A;  5JBC E;  3KCG L;  2VWL L;  3SW2 A;  1Z6E L;  1UZK A;  2KL7 A;  4A7I A;  5FDQ A;  1NZI A;  3QMO A;  2WPH E;  1EZQ B;  2WFT A;  3HO5 A;  4OTJ A;  1IQJ L;  1LMM A;  2AYL A;  1EBV A;  2JKH L; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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