2XBXL

Factor xa in complex with a pyrrolidine-3,4-dicarboxylic acid inhibitor
Total Genus 9
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
9
sequence length
50
structure length
44
Chain Sequence
CSLDNGDCDQFCVVCSCARGYTLADNGKACIPTGPYPCGKQTLE
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Discovery of a Factor Xa Inhibitor (3R,4R)-1-(2,2-Difluoro-Ethyl)-Pyrrolidine-3,4-Dicarboxylic Acid 3-[(5-Chloro-Pyridin-2-Yl)-Amide] 4-{[2-Fluoro-4-(2-Oxo-2H-Pyridin-1-Yl)-Phenyl]-Amide} as a Clinical Candidate.
pubmed doi rcsb
molecule tags Blood clotting
source organism Homo sapiens
molecule keywords ACTIVATED FACTOR XA HEAVY CHAIN
total genus 9
structure length 44
sequence length 50
ec nomenclature ec 3.4.21.6: Coagulation factor Xa.
pdb deposition date 2010-04-15

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
L PF14670 FXa_inhibition Coagulation Factor Xa inhibitory site
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.25.10 Mainly Beta Ribbon Laminin Laminin 2xbxL00
4PH9A 4NG9L 2BOUA 1ATBA 3N8ZA 4YZUB 2P93L 5L2ZL 1N1IA 2MGPA 2W2ME 1YO8A 3SW2A 1WU1B 3QCWA 1C5MF 2OYEP 3CS7L 3TK6B 4CSYA 5FDQA 2XBXL 2D1JB 2TGFA 2P3UA 4Y7BB 4JZFL 5JBCE 1CQEA 3LAQA 1W8BL 1F0RB 2P3FN 2W2PE 2K2TA 3ENSA 3KCGL 3V64C 1LQDA 2Y38A 2Y5GL 1HX2A 3M37L 4NA9L 1CCVA 2Y5HL 5KN5C 1EQGA 3PGHA 1HAFA 4X8TL 1NZIA 3GCXE 1HAEA 4G1MB 1EPJA 2P3TA 3QMOA 4XLWA 2W2QE 4ISIL 5CKNA 1L3YA 1DX5I 2WG3C 3LTFB 1IQML 1PTHA 1CVUA 1K37A 3QH0A 2W86A 1IQIL 1X7AL 1LMJA 3R05A 1NFYB 1URKA 1ADXA 2OYUP 4M10A 3NJPC 4ISHL 2XC4L 1PXXA 2KB9A 3CENL 2UWLB 4Y71B 1NFWB 2VVVL 3OLUA 3SOVA 1MQ6L 1F0SB 1CEJA 1EZQB 3SOQA 1BF9A 2WPLE 2VH6B 2I9BA 4CUDA 2ADXA 1KSNB 5E8DA 3N8XA 4MMYB 2RHPA 2PUQL 4XBMA 3ZYGA 2P94L 3KQBL 1NT0A 2NPRA 1JL9A 3U7UG 1IQLL 2UWOB 2J95B 4RRYA 4BXWA 3BT1A 3TGFA 1G1SA 1IGXA 5EGMB 1EGFA 3OLTA 2J2UB 2Y7XB 1IQKL 3N8WB 1DIYA 2EI8B 4E1GA 4D0FA 4ZXXL 5CKQA 1IQHL 3LC5B 3HS7A 4O1ZA 5CKMA 1EMNA 2BQ6A 1CX2A 2K2SB 2BO2A 3FBYA 1P0SL 2WPIE 2WG4B 3GISX 2I9AA 1FSBA 2KL7A 2W3KB 3HS5A 1U8CB 2VWOL 1KLJL 1DVAL 2PR3B 1WHFA 3N8WA 2PHBB 4OTJA 3BT2A 2CJIB 3DEMA 1IQFL 1K36A 1IQEL 2MGRA 4LMFA 4A7IA 2W3IB 4RRZA 5KIRA 1UZPA 2UWPB 3HO3A 5JVYA 3ASIA 2BOKL 3BPSE 3KQDL 1EBVA 3LC3B 3HPTA 2VH0B 5JVZA 2Y80B 4Z0LA 2XBVL 1KLOA 1IGZA 1G1RA 2VVUL 3FFGL 3MQEA 5I46L 2P16L 4Y79B 1PRHA 1IVOC 1AUTL 1NFUB 1ATEA 1Z6EL 4Y7AB 2Y82B 3Q7DA 1NPEB 2EI7B 1KLIL 3CA7A 4BXSA 4YT6L 1IQNL 3NTBA 1G1TA 5IKTA 4O02B 2P3FL 2FLBL 2J38B 2B7DL 2P95L 3ZYJB 1YUFA 3M36L 3F1SB 3TK5B 2FLRL 1HT5A 2J94B 3C9AC 3F6UL 4X8UL 3IITB 3KL6B 4D0EA 1IOXA 2VJ3A 2FD6A 2XBYL 4LORA 3ELAL 4BDXA 1XKBA 4Y76B 4OTYA 1IP0A 3LIWB 1EMOA 1F7MA 2YGPA 4RRWA 4X8SL 3KK6A 1XFEA 3HS6A 4RRXA 2BOHA 4Z0KB 1PGEA 5F19A 2MHPA 2WYJB 1W7XL 2G00L 3RR3A 1N7DA 1I0UA 3KRKA 3CFWA 1UZKA 2GD4A 4COXA 5IKQA 1TPGA 2H9EL 2W2NE 2RNLA 3TZIA 4NGAL 1B9WA 1RFNB 2Y7ZB 3TBDA 1IQGL 4JZDL 1Z6CA 3HO4A 1APQA 4ZXYL 1L5GB 1TOZA 1DQBA 3HO5A 1XKAL 3KQEL 3V65B 3NT1A 4ZHAB 4BTTA 3FCSB 1DDXA 1HCGB 1FFMA 1KIGL 1CCFA 2DDUA 2Y5FL 1M1XB 4TGFA 4BTIA 1LPZA 2W26B 1EPHA 1G1QA 4MMZB 1Q4GA 2VWLL 2EI6B 1SZBA 5L2YL 1NQLB 5CISA 5K0HB 2RA0L 3ZYIB 6COXA 5JB9E 1YUKB 2JKHL 4D90A 4C16A 1ZAQA 4BDWA 1EPGA 2XBWL 2J34B 5JBAE 2FLGA 2BQWA 3MDLA 3LTGD 2BQ7A 3IJEB 1APOA 1A3PA 2F9BL 1ATDA 1FAKL 1O5DL 1TLEA 5F1AA 1HJ7A 1EPIA 5JB8E 1HZ8A 1G2MB 3N8VA 1UZQA 1F7EA 1COUA 1G2LB 1ATAA 2W2OE 1CVWL 3GCWE 4BTUA 1P9JA 1OB1C 1GK5A 1XDTR 2XC5L 3POYA 4M11A 1HREA 1MQ5L 2YGOA 1LPKA 3N8YB 4JYVL 3P5BL 3K9XA 2AYLA 5COXA 4ZH8B 4YT7L 4AQTA 4XL1A 4Z6AL 1NFXB 4ZAEB 1EQHA 2P26A 2BMGA 2XC0L 3H5CB 4X8VL 1V3XB 1UZJA 2WPJE 2WPME 1JBUL 1IQJL 1IOEL 1HRFA 2P28B 2VVCK 2WFTA 3NTGA 1JV2B 1YUGA 2WPKE 4Y6DB 1LPGA 2J4IB 3N8YA 1HT8A 3LN1A 1FE2A 4JZEL 5L30L 4CUEA 5IKRA 1EAIC 2KV4A 1FJSL 5JW1A 3KQCL 1WHEA 3Q3KB 4JYUL 2VWNL 1FF7A 3SOBB 3LN0A 1QFKL 4FM5A 3U73A 2Q1JB 2Y81B 2FZZL 1U67A 4RUTA 3EGFA 1J9CL 5JBBE 2BOXA 3TH3L 1FAXL 1IJQA 2WYGB 1MOXC 4CUFA 2WPHE 1PFXL 1YGCL 4RS0A 2BZ6L 2M74A 2WFXB 4MMXB 2VWMK 5IKVA
chains in the Genus database with same CATH superfamily
4PH9A 4NG9L 2BOUA 1ATBA 3N8ZA 4YZUB 2P93L 5L2ZL 1N1IA 2MGPA 2W2ME 1YO8A 3SW2A 1WU1B 3QCWA 1C5MF 2OYEP 3CS7L 3TK6B 4CSYA 5FDQA 2XBXL 2D1JB 2TGFA 2P3UA 4Y7BB 4JZFL 5JBCE 1CQEA 3LAQA 1W8BL 1F0RB 2P3FN 2W2PE 2K2TA 2HORA 3ENSA 3KCGL 2YGQA 3V64C 1LQDA 2Y38A 2Y5GL 1HX2A 3M37L 4NA9L 1CCVA 2Y5HL 5KN5C 1EQGA 3PGHA 1HAFA 4X8TL 1NZIA 3GCXE 1HAEA 4G1MB 1EPJA 2P3TA 3QMOA 4XLWA 2W2QE 4ISIL 5CKNA 1L3YA 1DX5I 2WG3C 3LTFB 1IQML 1PTHA 1CVUA 1K37A 3QH0A 2W86A 1IQIL 1LK9A 1X7AL 1LMJA 3R05A 1NFYB 4A94C 1URKA 1ADXA 2OYUP 4M10A 3NJPC 4ISHL 2XC4L 1PXXA 2KB9A 3CENL 2UWLB 4Y71B 1NFWB 2VVVL 3OLUA 3SOVA 1MQ6L 1F0SB 1CEJA 1EZQB 3SOQA 1BF9A 2WPLE 2VH6B 2I9BA 4CUDA 2ADXA 1KSNB 5E8DA 3N8XA 4MMYB 2RHPA 2PUQL 4XBMA 3ZYGA 2P94L 3KQBL 1NT0A 2NPRA 1JL9A 3U7UG 1IQLL 2UWOB 2J95B 4RRYA 4BXWA 3BT1A 3TGFA 2KNIA 1G1SA 1IGXA 5EGMB 1EGFA 3OLTA 2J2UB 2Y7XB 1IQKL 3N8WB 1DIYA 2EI8B 4E1GA 4D0FA 4ZXXL 1LMMA 5CKQA 1IQHL 2HOXA 3LC5B 3HS7A 4O1ZA 5CKMA 1EMNA 2BQ6A 1CX2A 2K2SB 2BO2A 3FBYA 1P0SL 2WPIE 2WG4B 3GISX 2I9AA 1FSBA 2KL7A 2W3KB 3HS5A 3S6XA 1U8CB 2VWOL 1KLJL 1DVAL 2PR3B 1WHFA 2BT8A 3N8WA 2PHBB 4OTJA 3BT2A 2CJIB 3DEMA 1IQFL 1K36A 1IQEL 2MGRA 4LMFA 4A7IA 2W3IB 4RRZA 5KIRA 1UZPA 2UWPB 3HO3A 5JVYA 3ASIA 2BOKL 3BPSE 3KQDL 1EBVA 3LC3B 3HPTA 2VH0B 5JVZA 2Y80B 4Z0LA 2XBVL 1KLOA 1IGZA 1G1RA 2VVUL 3FFGL 3MQEA 5I46L 2P16L 4Y79B 1PRHA 1IVOC 1AUTL 1NFUB 1ATEA 1Z6EL 4Y7AB 2Y82B 3Q7DA 1NPEB 2EI7B 1KLIL 3CA7A 4BXSA 4YT6L 1IQNL 3NTBA 1G1TA 5IKTA 4O02B 2P3FL 2FLBL 2J38B 2B7DL 2P95L 3ZYJB 1YUFA 3M36L 3F1SB 3TK5B 2FLRL 1HT5A 2J94B 3C9AC 3F6UL 4X8UL 3IITB 2VRSA 3KL6B 4D0EA 1IOXA 2VJ3A 2FD6A 2XBYL 4LORA 3ELAL 4BDXA 1XKBA 4Y76B 4OTYA 1IP0A 3LIWB 1EMOA 1F7MA 1QIUA 2YGPA 4RRWA 4X8SL 3KK6A 1XFEA 3HS6A 4RRXA 2BOHA 4Z0KB 1PGEA 5F19A 2MHPA 2WYJB 1W7XL 2G00L 3RR3A 1N7DA 1I0UA 3KRKA 3CFWA 1UZKA 2GD4A 4COXA 5IKQA 1TPGA 2H9EL 2W2NE 2RNLA 3TZIA 4NGAL 1B9WA 1RFNB 2Y7ZB 3TBDA 1IQGL 4JZDL 1Z6CA 3HO4A 1APQA 1V1IA 4ZXYL 1L5GB 1TOZA 1DQBA 3HO5A 1XKAL 3KQEL 3V65B 3NT1A 4ZHAB 4BTTA 3FCSB 1DDXA 1HCGB 1FFMA 1KIGL 1CCFA 2DDUA 2Y5FL 1M1XB 4TGFA 4BTIA 1LPZA 2W26B 1EPHA 1G1QA 4MMZB 1Q4GA 2VWLL 2EI6B 1SZBA 5L2YL 1NQLB 5CISA 5K0HB 2RA0L 3ZYIB 6COXA 5JB9E 1YUKB 2JKHL 4D90A 4C16A 1ZAQA 4BDWA 1EPGA 2XBWL 2J34B 5JBAE 2FLGA 2BQWA 3MDLA 2WZPP 3LTGD 2BQ7A 3IJEB 1APOA 1A3PA 2F9BL 1ATDA 1FAKL 1O5DL 1TLEA 5F1AA 1HJ7A 1EPIA 5JB8E 1HZ8A 1G2MB 2BSFA 4GU4A 3N8VA 1UZQA 1F7EA 1COUA 1G2LB 1ATAA 2W2OE 1CVWL 3GCWE 4BTUA 1P9JA 1OB1C 1GK5A 1XDTR 2XC5L 3POYA 4M11A 1HREA 1MQ5L 2YGOA 1LPKA 3N8YB 1V1HA 4JYVL 3P5BL 3K9XA 2AYLA 5COXA 4ZH8B 4YT7L 4GU3A 4AQTA 4XL1A 4Z6AL 1NFXB 4ZAEB 1EQHA 2P26A 2BMGA 2XC0L 3H5CB 4X8VL 1V3XB 1UZJA 2WPJE 2WPME 1JBUL 1IQJL 2H9EC 1IOEL 1HRFA 2P28B 2VVCK 2WFTA 3NTGA 1JV2B 1YUGA 2WPKE 4Y6DB 1LPGA 2J4IB 3N8YA 1HT8A 3LN1A 2JJLA 1FE2A 4JZEL 5L30L 4CUEA 1KKEA 5IKRA 1EAIC 2KV4A 1FJSL 5JW1A 3KQCL 1WHEA 3Q3KB 4JYUL 2VWNL 1FF7A 3SOBB 3LN0A 1QFKL 4FM5A 3U73A 2Q1JB 2Y81B 2FZZL 1U67A 4RUTA 3EGFA 1J9CL 5JBBE 2BOXA 3TH3L 1FAXL 2BT7A 1IJQA 2WYGB 1MOXC 4CUFA 2WPHE 1PFXL 1YGCL 4RS0A 2BZ6L 2M74A 2WFXB 4MMXB 2VWMK 5IKVA
chains in the Genus database with same CATH topology
4PH9A 4NG9L 2BOUA 1ATBA 3N8ZA 4YZUB 2P93L 5L2ZL 1N1IA 2MGPA 2W2ME 1YO8A 3SW2A 1WU1B 3QCWA 1C5MF 2OYEP 3CS7L 3TK6B 4CSYA 5FDQA 2XBXL 2D1JB 2TGFA 2P3UA 4Y7BB 4JZFL 5JBCE 1CQEA 3LAQA 1W8BL 1F0RB 2P3FN 2W2PE 2K2TA 3ENSA 3KCGL 2YGQA 3V64C 1LQDA 2Y38A 2Y5GL 1HX2A 3M37L 4NA9L 1CCVA 2Y5HL 5KN5C 1EQGA 3PGHA 1HAFA 4X8TL 1NZIA 3GCXE 1HAEA 4G1MB 1EPJA 2P3TA 3QMOA 4XLWA 2W2QE 4ISIL 5CKNA 1L3YA 1DX5I 2WG3C 3LTFB 1IQML 1PTHA 1CVUA 1K37A 3QH0A 2W86A 1IQIL 1X7AL 1LMJA 3R05A 1NFYB 4A94C 1URKA 1ADXA 2OYUP 4M10A 3NJPC 4ISHL 2XC4L 1PXXA 2KB9A 3CENL 2UWLB 4Y71B 1NFWB 2VVVL 3OLUA 3SOVA 1MQ6L 1F0SB 1CEJA 1EZQB 3SOQA 1BF9A 2WPLE 2VH6B 2I9BA 4CUDA 2ADXA 1KSNB 5E8DA 3N8XA 4MMYB 2RHPA 2PUQL 4XBMA 3ZYGA 2P94L 3KQBL 1NT0A 2NPRA 1JL9A 3U7UG 1IQLL 2UWOB 2J95B 4RRYA 4BXWA 3BT1A 3TGFA 2KNIA 1G1SA 1IGXA 5EGMB 1EGFA 3OLTA 2J2UB 2Y7XB 1IQKL 3N8WB 1DIYA 2EI8B 4E1GA 4D0FA 4ZXXL 1LMMA 5CKQA 1IQHL 3LC5B 3HS7A 4O1ZA 5CKMA 1EMNA 2BQ6A 1CX2A 2K2SB 2BO2A 3FBYA 1P0SL 2WPIE 2WG4B 3GISX 2I9AA 1FSBA 2KL7A 2W3KB 3HS5A 3S6XA 1U8CB 2VWOL 1KLJL 1DVAL 2PR3B 1WHFA 3N8WA 2PHBB 4OTJA 3BT2A 2CJIB 3DEMA 1IQFL 1K36A 1IQEL 2MGRA 4LMFA 4A7IA 2W3IB 4RRZA 5KIRA 1UZPA 2UWPB 3HO3A 5JVYA 3ASIA 2BOKL 3BPSE 3KQDL 1EBVA 3LC3B 3HPTA 2VH0B 5JVZA 2Y80B 4Z0LA 2XBVL 1KLOA 1IGZA 1G1RA 2VVUL 3FFGL 3MQEA 5I46L 2P16L 4Y79B 1PRHA 1IVOC 1AUTL 1NFUB 1ATEA 1Z6EL 4Y7AB 2Y82B 3Q7DA 1NPEB 2EI7B 1KLIL 3CA7A 4BXSA 4YT6L 1IQNL 3NTBA 1G1TA 5IKTA 4O02B 2P3FL 2FLBL 2J38B 2B7DL 2P95L 3ZYJB 1YUFA 3M36L 3F1SB 3TK5B 2FLRL 1HT5A 2J94B 3C9AC 3F6UL 4X8UL 3IITB 3KL6B 4D0EA 1IOXA 2VJ3A 2FD6A 2XBYL 4LORA 3ELAL 4BDXA 1XKBA 4Y76B 4OTYA 1IP0A 3LIWB 1EMOA 1F7MA 2YGPA 4RRWA 4X8SL 3KK6A 1XFEA 3HS6A 4RRXA 2BOHA 4Z0KB 1PGEA 5F19A 2MHPA 2WYJB 1W7XL 2G00L 3RR3A 1N7DA 1I0UA 3KRKA 3CFWA 1UZKA 2GD4A 4COXA 5IKQA 1TPGA 2H9EL 2W2NE 2RNLA 3TZIA 4NGAL 1B9WA 1RFNB 2Y7ZB 3TBDA 1IQGL 4JZDL 1Z6CA 3HO4A 1APQA 4ZXYL 1L5GB 1TOZA 1DQBA 3HO5A 1XKAL 3KQEL 3V65B 3NT1A 4ZHAB 4BTTA 3FCSB 1DDXA 1HCGB 1FFMA 1KIGL 1CCFA 2DDUA 2Y5FL 1M1XB 4TGFA 4BTIA 1LPZA 2W26B 1EPHA 1G1QA 4MMZB 1Q4GA 2VWLL 2EI6B 1SZBA 5L2YL 1NQLB 5CISA 5K0HB 2RA0L 3ZYIB 6COXA 5JB9E 1YUKB 2JKHL 4D90A 4C16A 1ZAQA 4BDWA 1EPGA 2XBWL 2J34B 5JBAE 2FLGA 2BQWA 3MDLA 2WZPP 3LTGD 2BQ7A 3IJEB 1APOA 1A3PA 2F9BL 1ATDA 1FAKL 1O5DL 1TLEA 5F1AA 1HJ7A 1EPIA 5JB8E 1HZ8A 1G2MB 3N8VA 1UZQA 1F7EA 1COUA 1G2LB 1ATAA 2W2OE 1CVWL 3GCWE 4BTUA 1P9JA 1OB1C 1GK5A 1XDTR 2XC5L 3POYA 4M11A 1HREA 1MQ5L 2YGOA 1LPKA 3N8YB 4JYVL 3P5BL 3K9XA 2AYLA 5COXA 4ZH8B 4YT7L 4AQTA 4XL1A 4Z6AL 1NFXB 4ZAEB 1EQHA 2P26A 2BMGA 2XC0L 3H5CB 4X8VL 1V3XB 1UZJA 2WPJE 2WPME 1JBUL 1IQJL 2H9EC 1IOEL 1HRFA 2P28B 2VVCK 2WFTA 3NTGA 1JV2B 1YUGA 2WPKE 4Y6DB 1LPGA 2J4IB 3N8YA 1HT8A 3LN1A 1FE2A 4JZEL 5L30L 4CUEA 5IKRA 1EAIC 2KV4A 1FJSL 5JW1A 3KQCL 1WHEA 3Q3KB 4JYUL 2VWNL 1FF7A 3SOBB 3LN0A 1QFKL 4FM5A 3U73A 2Q1JB 2Y81B 2FZZL 1U67A 4RUTA 3EGFA 1J9CL 5JBBE 2BOXA 3TH3L 1FAXL 1IJQA 2WYGB 1MOXC 4CUFA 2WPHE 1PFXL 1YGCL 4RS0A 2BZ6L 2M74A 2WFXB 4MMXB 2VWMK 5IKVA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4PH9 A;  4NG9 L;  2BOU A;  1ATB A;  3N8Z A;  4YZU B;  2P93 L;  5L2Z L;  1N1I A;  2MGP A;  2W2M E;  1YO8 A;  3SW2 A;  1WU1 B;  3QCW A;  1C5M F;  2OYE P;  3CS7 L;  3TK6 B;  4CSY A;  5FDQ A;  2XBX L;  2D1J B;  2TGF A;  2P3U A;  4Y7B B;  4JZF L;  5JBC E;  1CQE A;  3LAQ A;  1W8B L;  1F0R B;  2P3F N;  2W2P E;  2K2T A;  3ENS A;  3KCG L;  3V64 C;  1LQD A;  2Y38 A;  2Y5G L;  1HX2 A;  3M37 L;  4NA9 L;  1CCV A;  2Y5H L;  5KN5 C;  1EQG A;  3PGH A;  1HAF A;  4X8T L;  1NZI A;  3GCX E;  1HAE A;  4G1M B;  1EPJ A;  2P3T A;  3QMO A;  4XLW A;  2W2Q E;  4ISI L;  5CKN A;  1L3Y A;  1DX5 I;  2WG3 C;  3LTF B;  1IQM L;  1PTH A;  1CVU A;  1K37 A;  3QH0 A;  2W86 A;  1IQI L;  1X7A L;  1LMJ A;  3R05 A;  1NFY B;  1URK A;  1ADX A;  2OYU P;  4M10 A;  3NJP C;  4ISH L;  2XC4 L;  1PXX A;  2KB9 A;  3CEN L;  2UWL B;  4Y71 B;  1NFW B;  2VVV L;  3OLU A;  3SOV A;  1MQ6 L;  1F0S B;  1CEJ A;  1EZQ B;  3SOQ A;  1BF9 A;  2WPL E;  2VH6 B;  2I9B A;  4CUD A;  2ADX A;  1KSN B;  5E8D A;  3N8X A;  4MMY B;  2RHP A;  2PUQ L;  4XBM A;  3ZYG A;  2P94 L;  3KQB L;  1NT0 A;  2NPR A;  1JL9 A;  3U7U G;  1IQL L;  2UWO B;  2J95 B;  4RRY A;  4BXW A;  3BT1 A;  3TGF A;  1G1S A;  1IGX A;  5EGM B;  1EGF A;  3OLT A;  2J2U B;  2Y7X B;  1IQK L;  3N8W B;  1DIY A;  2EI8 B;  4E1G A;  4D0F A;  4ZXX L;  5CKQ A;  1IQH L;  3LC5 B;  3HS7 A;  4O1Z A;  5CKM A;  1EMN A;  2BQ6 A;  1CX2 A;  2K2S B;  2BO2 A;  3FBY A;  1P0S L;  2WPI E;  2WG4 B;  3GIS X;  2I9A A;  1FSB A;  2KL7 A;  2W3K B;  3HS5 A;  1U8C B;  2VWO L;  1KLJ L;  1DVA L;  2PR3 B;  1WHF A;  3N8W A;  2PHB B;  4OTJ A;  3BT2 A;  2CJI B;  3DEM A;  1IQF L;  1K36 A;  1IQE L;  2MGR A;  4LMF A;  4A7I A;  2W3I B;  4RRZ A;  5KIR A;  1UZP A;  2UWP B;  3HO3 A;  5JVY A;  3ASI A;  2BOK L;  3BPS E;  3KQD L;  1EBV A;  3LC3 B;  3HPT A;  2VH0 B;  5JVZ A;  2Y80 B;  4Z0L A;  2XBV L;  1KLO A;  1IGZ A;  1G1R A;  2VVU L;  3FFG L;  3MQE A;  5I46 L;  2P16 L;  4Y79 B;  1PRH A;  1IVO C;  1AUT L;  1NFU B;  1ATE A;  1Z6E L;  4Y7A B;  2Y82 B;  3Q7D A;  1NPE B;  2EI7 B;  1KLI L;  3CA7 A;  4BXS A;  4YT6 L;  1IQN L;  3NTB A;  1G1T A;  5IKT A;  4O02 B;  2P3F L;  2FLB L;  2J38 B;  2B7D L;  2P95 L;  3ZYJ B;  1YUF A;  3M36 L;  3F1S B;  3TK5 B;  2FLR L;  1HT5 A;  2J94 B;  3C9A C;  3F6U L;  4X8U L;  3IIT B;  3KL6 B;  4D0E A;  1IOX A;  2VJ3 A;  2FD6 A;  2XBY L;  4LOR A;  3ELA L;  4BDX A;  1XKB A;  4Y76 B;  4OTY A;  1IP0 A;  3LIW B;  1EMO A;  1F7M A;  2YGP A;  4RRW A;  4X8S L;  3KK6 A;  1XFE A;  3HS6 A;  4RRX A;  2BOH A;  4Z0K B;  1PGE A;  5F19 A;  2MHP A;  2WYJ B;  1W7X L;  2G00 L;  3RR3 A;  1N7D A;  1I0U A;  3KRK A;  3CFW A;  1UZK A;  2GD4 A;  4COX A;  5IKQ A;  1TPG A;  2H9E L;  2W2N E;  2RNL A;  3TZI A;  4NGA L;  1B9W A;  1RFN B;  2Y7Z B;  3TBD A;  1IQG L;  4JZD L;  1Z6C A;  3HO4 A;  1APQ A;  4ZXY L;  1L5G B;  1TOZ A;  1DQB A;  3HO5 A;  1XKA L;  3KQE L;  3V65 B;  3NT1 A;  4ZHA B;  4BTT A;  3FCS B;  1DDX A;  1HCG B;  1FFM A;  1KIG L;  1CCF A;  2DDU A;  2Y5F L;  1M1X B;  4TGF A;  4BTI A;  1LPZ A;  2W26 B;  1EPH A;  1G1Q A;  4MMZ B;  1Q4G A;  2VWL L;  2EI6 B;  1SZB A;  5L2Y L;  1NQL B;  5CIS A;  5K0H B;  2RA0 L;  3ZYI B;  6COX A;  5JB9 E;  1YUK B;  2JKH L;  4D90 A;  4C16 A;  1ZAQ A;  4BDW A;  1EPG A;  2XBW L;  2J34 B;  5JBA E;  2FLG A;  2BQW A;  3MDL A;  3LTG D;  2BQ7 A;  3IJE B;  1APO A;  1A3P A;  2F9B L;  1ATD A;  1FAK L;  1O5D L;  1TLE A;  5F1A A;  1HJ7 A;  1EPI A;  5JB8 E;  1HZ8 A;  1G2M B;  3N8V A;  1UZQ A;  1F7E A;  1COU A;  1G2L B;  1ATA A;  2W2O E;  1CVW L;  3GCW E;  4BTU A;  1P9J A;  1OB1 C;  1GK5 A;  1XDT R;  2XC5 L;  3POY A;  4M11 A;  1HRE A;  1MQ5 L;  2YGO A;  1LPK A;  3N8Y B;  4JYV L;  3P5B L;  3K9X A;  2AYL A;  5COX A;  4ZH8 B;  4YT7 L;  4AQT A;  4XL1 A;  4Z6A L;  1NFX B;  4ZAE B;  1EQH A;  2P26 A;  2BMG A;  2XC0 L;  3H5C B;  4X8V L;  1V3X B;  1UZJ A;  2WPJ E;  2WPM E;  1JBU L;  1IQJ L;  1IOE L;  1HRF A;  2P28 B;  2VVC K;  2WFT A;  3NTG A;  1JV2 B;  1YUG A;  2WPK E;  4Y6D B;  1LPG A;  2J4I B;  3N8Y A;  1HT8 A;  3LN1 A;  1FE2 A;  4JZE L;  5L30 L;  4CUE A;  5IKR A;  1EAI C;  2KV4 A;  1FJS L;  5JW1 A;  3KQC L;  1WHE A;  3Q3K B;  4JYU L;  2VWN L;  1FF7 A;  3SOB B;  3LN0 A;  1QFK L;  4FM5 A;  3U73 A;  2Q1J B;  2Y81 B;  2FZZ L;  1U67 A;  4RUT A;  3EGF A;  1J9C L;  5JBB E;  2BOX A;  3TH3 L;  1FAX L;  1IJQ A;  2WYG B;  1MOX C;  4CUF A;  2WPH E;  1PFX L;  1YGC L;  4RS0 A;  2BZ6 L;  2M74 A;  2WFX B;  4MMX B;  2VWM K;  5IKV A; 
#chains in the Genus database with same CATH topology
 4PH9 A;  4NG9 L;  2BOU A;  1ATB A;  3N8Z A;  4YZU B;  2P93 L;  5L2Z L;  1N1I A;  2MGP A;  2W2M E;  1YO8 A;  3SW2 A;  1WU1 B;  3QCW A;  1C5M F;  2OYE P;  3CS7 L;  3TK6 B;  4CSY A;  5FDQ A;  2XBX L;  2D1J B;  2TGF A;  2P3U A;  4Y7B B;  4JZF L;  5JBC E;  1CQE A;  3LAQ A;  1W8B L;  1F0R B;  2P3F N;  2W2P E;  2K2T A;  2HOR A;  3ENS A;  3KCG L;  2YGQ A;  3V64 C;  1LQD A;  2Y38 A;  2Y5G L;  1HX2 A;  3M37 L;  4NA9 L;  1CCV A;  2Y5H L;  5KN5 C;  1EQG A;  3PGH A;  1HAF A;  4X8T L;  1NZI A;  3GCX E;  1HAE A;  4G1M B;  1EPJ A;  2P3T A;  3QMO A;  4XLW A;  2W2Q E;  4ISI L;  5CKN A;  1L3Y A;  1DX5 I;  2WG3 C;  3LTF B;  1IQM L;  1PTH A;  1CVU A;  1K37 A;  3QH0 A;  2W86 A;  1IQI L;  1LK9 A;  1X7A L;  1LMJ A;  3R05 A;  1NFY B;  4A94 C;  1URK A;  1ADX A;  2OYU P;  4M10 A;  3NJP C;  4ISH L;  2XC4 L;  1PXX A;  2KB9 A;  3CEN L;  2UWL B;  4Y71 B;  1NFW B;  2VVV L;  3OLU A;  3SOV A;  1MQ6 L;  1F0S B;  1CEJ A;  1EZQ B;  3SOQ A;  1BF9 A;  2WPL E;  2VH6 B;  2I9B A;  4CUD A;  2ADX A;  1KSN B;  5E8D A;  3N8X A;  4MMY B;  2RHP A;  2PUQ L;  4XBM A;  3ZYG A;  2P94 L;  3KQB L;  1NT0 A;  2NPR A;  1JL9 A;  3U7U G;  1IQL L;  2UWO B;  2J95 B;  4RRY A;  4BXW A;  3BT1 A;  3TGF A;  2KNI A;  1G1S A;  1IGX A;  5EGM B;  1EGF A;  3OLT A;  2J2U B;  2Y7X B;  1IQK L;  3N8W B;  1DIY A;  2EI8 B;  4E1G A;  4D0F A;  4ZXX L;  1LMM A;  5CKQ A;  1IQH L;  2HOX A;  3LC5 B;  3HS7 A;  4O1Z A;  5CKM A;  1EMN A;  2BQ6 A;  1CX2 A;  2K2S B;  2BO2 A;  3FBY A;  1P0S L;  2WPI E;  2WG4 B;  3GIS X;  2I9A A;  1FSB A;  2KL7 A;  2W3K B;  3HS5 A;  3S6X A;  1U8C B;  2VWO L;  1KLJ L;  1DVA L;  2PR3 B;  1WHF A;  2BT8 A;  3N8W A;  2PHB B;  4OTJ A;  3BT2 A;  2CJI B;  3DEM A;  1IQF L;  1K36 A;  1IQE L;  2MGR A;  4LMF A;  4A7I A;  2W3I B;  4RRZ A;  5KIR A;  1UZP A;  2UWP B;  3HO3 A;  5JVY A;  3ASI A;  2BOK L;  3BPS E;  3KQD L;  1EBV A;  3LC3 B;  3HPT A;  2VH0 B;  5JVZ A;  2Y80 B;  4Z0L A;  2XBV L;  1KLO A;  1IGZ A;  1G1R A;  2VVU L;  3FFG L;  3MQE A;  5I46 L;  2P16 L;  4Y79 B;  1PRH A;  1IVO C;  1AUT L;  1NFU B;  1ATE A;  1Z6E L;  4Y7A B;  2Y82 B;  3Q7D A;  1NPE B;  2EI7 B;  1KLI L;  3CA7 A;  4BXS A;  4YT6 L;  1IQN L;  3NTB A;  1G1T A;  5IKT A;  4O02 B;  2P3F L;  2FLB L;  2J38 B;  2B7D L;  2P95 L;  3ZYJ B;  1YUF A;  3M36 L;  3F1S B;  3TK5 B;  2FLR L;  1HT5 A;  2J94 B;  3C9A C;  3F6U L;  4X8U L;  3IIT B;  2VRS A;  3KL6 B;  4D0E A;  1IOX A;  2VJ3 A;  2FD6 A;  2XBY L;  4LOR A;  3ELA L;  4BDX A;  1XKB A;  4Y76 B;  4OTY A;  1IP0 A;  3LIW B;  1EMO A;  1F7M A;  1QIU A;  2YGP A;  4RRW A;  4X8S L;  3KK6 A;  1XFE A;  3HS6 A;  4RRX A;  2BOH A;  4Z0K B;  1PGE A;  5F19 A;  2MHP A;  2WYJ B;  1W7X L;  2G00 L;  3RR3 A;  1N7D A;  1I0U A;  3KRK A;  3CFW A;  1UZK A;  2GD4 A;  4COX A;  5IKQ A;  1TPG A;  2H9E L;  2W2N E;  2RNL A;  3TZI A;  4NGA L;  1B9W A;  1RFN B;  2Y7Z B;  3TBD A;  1IQG L;  4JZD L;  1Z6C A;  3HO4 A;  1APQ A;  1V1I A;  4ZXY L;  1L5G B;  1TOZ A;  1DQB A;  3HO5 A;  1XKA L;  3KQE L;  3V65 B;  3NT1 A;  4ZHA B;  4BTT A;  3FCS B;  1DDX A;  1HCG B;  1FFM A;  1KIG L;  1CCF A;  2DDU A;  2Y5F L;  1M1X B;  4TGF A;  4BTI A;  1LPZ A;  2W26 B;  1EPH A;  1G1Q A;  4MMZ B;  1Q4G A;  2VWL L;  2EI6 B;  1SZB A;  5L2Y L;  1NQL B;  5CIS A;  5K0H B;  2RA0 L;  3ZYI B;  6COX A;  5JB9 E;  1YUK B;  2JKH L;  4D90 A;  4C16 A;  1ZAQ A;  4BDW A;  1EPG A;  2XBW L;  2J34 B;  5JBA E;  2FLG A;  2BQW A;  3MDL A;  2WZP P;  3LTG D;  2BQ7 A;  3IJE B;  1APO A;  1A3P A;  2F9B L;  1ATD A;  1FAK L;  1O5D L;  1TLE A;  5F1A A;  1HJ7 A;  1EPI A;  5JB8 E;  1HZ8 A;  1G2M B;  2BSF A;  4GU4 A;  3N8V A;  1UZQ A;  1F7E A;  1COU A;  1G2L B;  1ATA A;  2W2O E;  1CVW L;  3GCW E;  4BTU A;  1P9J A;  1OB1 C;  1GK5 A;  1XDT R;  2XC5 L;  3POY A;  4M11 A;  1HRE A;  1MQ5 L;  2YGO A;  1LPK A;  3N8Y B;  1V1H A;  4JYV L;  3P5B L;  3K9X A;  2AYL A;  5COX A;  4ZH8 B;  4YT7 L;  4GU3 A;  4AQT A;  4XL1 A;  4Z6A L;  1NFX B;  4ZAE B;  1EQH A;  2P26 A;  2BMG A;  2XC0 L;  3H5C B;  4X8V L;  1V3X B;  1UZJ A;  2WPJ E;  2WPM E;  1JBU L;  1IQJ L;  2H9E C;  1IOE L;  1HRF A;  2P28 B;  2VVC K;  2WFT A;  3NTG A;  1JV2 B;  1YUG A;  2WPK E;  4Y6D B;  1LPG A;  2J4I B;  3N8Y A;  1HT8 A;  3LN1 A;  2JJL A;  1FE2 A;  4JZE L;  5L30 L;  4CUE A;  1KKE A;  5IKR A;  1EAI C;  2KV4 A;  1FJS L;  5JW1 A;  3KQC L;  1WHE A;  3Q3K B;  4JYU L;  2VWN L;  1FF7 A;  3SOB B;  3LN0 A;  1QFK L;  4FM5 A;  3U73 A;  2Q1J B;  2Y81 B;  2FZZ L;  1U67 A;  4RUT A;  3EGF A;  1J9C L;  5JBB E;  2BOX A;  3TH3 L;  1FAX L;  2BT7 A;  1IJQ A;  2WYG B;  1MOX C;  4CUF A;  2WPH E;  1PFX L;  1YGC L;  4RS0 A;  2BZ6 L;  2M74 A;  2WFX B;  4MMX B;  2VWM K;  5IKV A; 
#chains in the Genus database with same CATH homology
 4PH9 A;  4NG9 L;  2BOU A;  1ATB A;  3N8Z A;  4YZU B;  2P93 L;  5L2Z L;  1N1I A;  2MGP A;  2W2M E;  1YO8 A;  3SW2 A;  1WU1 B;  3QCW A;  1C5M F;  2OYE P;  3CS7 L;  3TK6 B;  4CSY A;  5FDQ A;  2XBX L;  2D1J B;  2TGF A;  2P3U A;  4Y7B B;  4JZF L;  5JBC E;  1CQE A;  3LAQ A;  1W8B L;  1F0R B;  2P3F N;  2W2P E;  2K2T A;  3ENS A;  3KCG L;  2YGQ A;  3V64 C;  1LQD A;  2Y38 A;  2Y5G L;  1HX2 A;  3M37 L;  4NA9 L;  1CCV A;  2Y5H L;  5KN5 C;  1EQG A;  3PGH A;  1HAF A;  4X8T L;  1NZI A;  3GCX E;  1HAE A;  4G1M B;  1EPJ A;  2P3T A;  3QMO A;  4XLW A;  2W2Q E;  4ISI L;  5CKN A;  1L3Y A;  1DX5 I;  2WG3 C;  3LTF B;  1IQM L;  1PTH A;  1CVU A;  1K37 A;  3QH0 A;  2W86 A;  1IQI L;  1X7A L;  1LMJ A;  3R05 A;  1NFY B;  4A94 C;  1URK A;  1ADX A;  2OYU P;  4M10 A;  3NJP C;  4ISH L;  2XC4 L;  1PXX A;  2KB9 A;  3CEN L;  2UWL B;  4Y71 B;  1NFW B;  2VVV L;  3OLU A;  3SOV A;  1MQ6 L;  1F0S B;  1CEJ A;  1EZQ B;  3SOQ A;  1BF9 A;  2WPL E;  2VH6 B;  2I9B A;  4CUD A;  2ADX A;  1KSN B;  5E8D A;  3N8X A;  4MMY B;  2RHP A;  2PUQ L;  4XBM A;  3ZYG A;  2P94 L;  3KQB L;  1NT0 A;  2NPR A;  1JL9 A;  3U7U G;  1IQL L;  2UWO B;  2J95 B;  4RRY A;  4BXW A;  3BT1 A;  3TGF A;  2KNI A;  1G1S A;  1IGX A;  5EGM B;  1EGF A;  3OLT A;  2J2U B;  2Y7X B;  1IQK L;  3N8W B;  1DIY A;  2EI8 B;  4E1G A;  4D0F A;  4ZXX L;  1LMM A;  5CKQ A;  1IQH L;  3LC5 B;  3HS7 A;  4O1Z A;  5CKM A;  1EMN A;  2BQ6 A;  1CX2 A;  2K2S B;  2BO2 A;  3FBY A;  1P0S L;  2WPI E;  2WG4 B;  3GIS X;  2I9A A;  1FSB A;  2KL7 A;  2W3K B;  3HS5 A;  3S6X A;  1U8C B;  2VWO L;  1KLJ L;  1DVA L;  2PR3 B;  1WHF A;  3N8W A;  2PHB B;  4OTJ A;  3BT2 A;  2CJI B;  3DEM A;  1IQF L;  1K36 A;  1IQE L;  2MGR A;  4LMF A;  4A7I A;  2W3I B;  4RRZ A;  5KIR A;  1UZP A;  2UWP B;  3HO3 A;  5JVY A;  3ASI A;  2BOK L;  3BPS E;  3KQD L;  1EBV A;  3LC3 B;  3HPT A;  2VH0 B;  5JVZ A;  2Y80 B;  4Z0L A;  2XBV L;  1KLO A;  1IGZ A;  1G1R A;  2VVU L;  3FFG L;  3MQE A;  5I46 L;  2P16 L;  4Y79 B;  1PRH A;  1IVO C;  1AUT L;  1NFU B;  1ATE A;  1Z6E L;  4Y7A B;  2Y82 B;  3Q7D A;  1NPE B;  2EI7 B;  1KLI L;  3CA7 A;  4BXS A;  4YT6 L;  1IQN L;  3NTB A;  1G1T A;  5IKT A;  4O02 B;  2P3F L;  2FLB L;  2J38 B;  2B7D L;  2P95 L;  3ZYJ B;  1YUF A;  3M36 L;  3F1S B;  3TK5 B;  2FLR L;  1HT5 A;  2J94 B;  3C9A C;  3F6U L;  4X8U L;  3IIT B;  3KL6 B;  4D0E A;  1IOX A;  2VJ3 A;  2FD6 A;  2XBY L;  4LOR A;  3ELA L;  4BDX A;  1XKB A;  4Y76 B;  4OTY A;  1IP0 A;  3LIW B;  1EMO A;  1F7M A;  2YGP A;  4RRW A;  4X8S L;  3KK6 A;  1XFE A;  3HS6 A;  4RRX A;  2BOH A;  4Z0K B;  1PGE A;  5F19 A;  2MHP A;  2WYJ B;  1W7X L;  2G00 L;  3RR3 A;  1N7D A;  1I0U A;  3KRK A;  3CFW A;  1UZK A;  2GD4 A;  4COX A;  5IKQ A;  1TPG A;  2H9E L;  2W2N E;  2RNL A;  3TZI A;  4NGA L;  1B9W A;  1RFN B;  2Y7Z B;  3TBD A;  1IQG L;  4JZD L;  1Z6C A;  3HO4 A;  1APQ A;  4ZXY L;  1L5G B;  1TOZ A;  1DQB A;  3HO5 A;  1XKA L;  3KQE L;  3V65 B;  3NT1 A;  4ZHA B;  4BTT A;  3FCS B;  1DDX A;  1HCG B;  1FFM A;  1KIG L;  1CCF A;  2DDU A;  2Y5F L;  1M1X B;  4TGF A;  4BTI A;  1LPZ A;  2W26 B;  1EPH A;  1G1Q A;  4MMZ B;  1Q4G A;  2VWL L;  2EI6 B;  1SZB A;  5L2Y L;  1NQL B;  5CIS A;  5K0H B;  2RA0 L;  3ZYI B;  6COX A;  5JB9 E;  1YUK B;  2JKH L;  4D90 A;  4C16 A;  1ZAQ A;  4BDW A;  1EPG A;  2XBW L;  2J34 B;  5JBA E;  2FLG A;  2BQW A;  3MDL A;  2WZP P;  3LTG D;  2BQ7 A;  3IJE B;  1APO A;  1A3P A;  2F9B L;  1ATD A;  1FAK L;  1O5D L;  1TLE A;  5F1A A;  1HJ7 A;  1EPI A;  5JB8 E;  1HZ8 A;  1G2M B;  3N8V A;  1UZQ A;  1F7E A;  1COU A;  1G2L B;  1ATA A;  2W2O E;  1CVW L;  3GCW E;  4BTU A;  1P9J A;  1OB1 C;  1GK5 A;  1XDT R;  2XC5 L;  3POY A;  4M11 A;  1HRE A;  1MQ5 L;  2YGO A;  1LPK A;  3N8Y B;  4JYV L;  3P5B L;  3K9X A;  2AYL A;  5COX A;  4ZH8 B;  4YT7 L;  4AQT A;  4XL1 A;  4Z6A L;  1NFX B;  4ZAE B;  1EQH A;  2P26 A;  2BMG A;  2XC0 L;  3H5C B;  4X8V L;  1V3X B;  1UZJ A;  2WPJ E;  2WPM E;  1JBU L;  1IQJ L;  2H9E C;  1IOE L;  1HRF A;  2P28 B;  2VVC K;  2WFT A;  3NTG A;  1JV2 B;  1YUG A;  2WPK E;  4Y6D B;  1LPG A;  2J4I B;  3N8Y A;  1HT8 A;  3LN1 A;  1FE2 A;  4JZE L;  5L30 L;  4CUE A;  5IKR A;  1EAI C;  2KV4 A;  1FJS L;  5JW1 A;  3KQC L;  1WHE A;  3Q3K B;  4JYU L;  2VWN L;  1FF7 A;  3SOB B;  3LN0 A;  1QFK L;  4FM5 A;  3U73 A;  2Q1J B;  2Y81 B;  2FZZ L;  1U67 A;  4RUT A;  3EGF A;  1J9C L;  5JBB E;  2BOX A;  3TH3 L;  1FAX L;  1IJQ A;  2WYG B;  1MOX C;  4CUF A;  2WPH E;  1PFX L;  1YGC L;  4RS0 A;  2BZ6 L;  2M74 A;  2WFX B;  4MMX B;  2VWM K;  5IKV A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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