2XC0L

Factor xa in complex with a pyrrolidine-3,4-dicarboxylic acid inhibitor
Total Genus 9
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
9
sequence length
50
structure length
44
Chain Sequence
CSLDNGDCDQFCVVCSCARGYTLADNGKACIPTGPYPCGKQTLE
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Discovery of a Factor Xa Inhibitor (3R,4R)-1-(2,2-Difluoro-Ethyl)-Pyrrolidine-3,4-Dicarboxylic Acid 3-[(5-Chloro-Pyridin-2-Yl)-Amide] 4-{[2-Fluoro-4-(2-Oxo-2H-Pyridin-1-Yl)-Phenyl]-Amide} as a Clinical Candidate.
pubmed doi rcsb
molecule tags Blood clotting
source organism Homo sapiens
molecule keywords ACTIVATED FACTOR XA HEAVY CHAIN
total genus 9
structure length 44
sequence length 50
ec nomenclature ec 3.4.21.6: Coagulation factor Xa.
pdb deposition date 2010-04-15

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
L PF14670 FXa_inhibition Coagulation Factor Xa inhibitory site
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.25.10 Mainly Beta Ribbon Laminin Laminin 2xc0L00
2P3UA 3KL6B 5IKRA 3KQBL 1AUTL 1WHEA 2J38B 1MQ6L 4Y7AB 1EGFA 4JYVL 5FDQA 4XBMA 4XLWA 1HRFA 1HCGB 4Y79B 1NQLB 4PH9A 1HZ8A 4AQTA 2Y7ZB 1TPGA 1HAEA 1BF9A 2PR3B 2FZZL 4Y76B 2XBXL 1UZQA 4CUDA 3EGFA 2XC0L 2P94L 2FLGA 3HO3A 4D0EA 3LTGD 2EI6B 4MMYB 1IOEL 1CCFA 4X8VL 1IQIL 4LORA 1XFEA 1J9CL 3LN1A 3CFWA 1EPIA 2Y5FL 1NZIA 2Y7XB 1IJQA 3TZIA 1FAXL 2W2QE 2P28B 4YT7L 3GCWE 2W3KB 1HJ7A 3TBDA 3KK6A 1MQ5L 4C16A 5K0HB 1PTHA 2J4IB 1EPGA 1EMNA 5IKVA 3KCGL 4NG9L 3ASIA 1CEJA 1IQJL 3RR3A 2P16L 3TK6B 2WFXB 2WPME 3C9AC 4JZFL 1EQGA 1NFUB 4Z0KB 1HT5A 4MMZB 2J34B 1IOXA 1EZQB 1JBUL 2WPHE 4RRWA 3N8VA 1IQHL 4X8UL 3HS6A 2UWLB 5CISA 2D1JB 2BOUA 3BT1A 1JL9A 3POYA 5I46L 1ADXA 1HAFA 2J2UB 4ZXXL 3OLTA 3GISX 3KRKA 2W2PE 6COXA 1EPJA 3N8WB 3LIWB 1YGCL 1KLOA 3R05A 1C5MF 2KB9A 1APOA 1UZKA 2VVUL 3NTGA 2XC4L 2WPLE 1FJSL 1KSNB 1DIYA 3CA7A 1ATAA 2MGPA 2VVVL 1XKBA 1I0UA 1UZJA 4RS0A 3LTFB 2BOHA 2J95B 3P5BL 4YZUB 1IQEL 1FAKL 1QFKL 2AYLA 1IQGL 1KIGL 1K37A 1CX2A 2OYEP 2VWLL 1G1QA 1F7MA 2NPRA 1HT8A 3HO4A 4E1GA 3DEMA 1EQHA 3LAQA 2W2OE 3Q7DA 4CUEA 5F19A 2MGRA 3CS7L 2XC5L 1K36A 2VWNL 1ATDA 2K2TA 2M74A 1V3XB 3LC5B 1KLIL 2Y81B 4BDXA 1L3YA 2WYJB 1IQML 1W7XL 1G1RA 4NGAL 3TGFA 2P3TA 2BOXA 4BDWA 5KN5C 3FBYA 3KQDL 4M10A 1TLEA 3N8XA 4M11A 1B9WA 2FLBL 4Y7BB 1Z6EL 4ZHAB 3OLUA 4Z0LA 1CCVA 4COXA 2VH0B 5JVYA 1LPZA 3SW2A 3SOQA 2XBYL 1SZBA 2BQ6A 2RNLA 2YGOA 2EI8B 1L5GB 2UWOB 3N8WA 2JKHL 3U7UG 3NTBA 4OTYA 3M36L 3TK5B 2MHPA 3NT1A 4D90A 1RFNB 1IQNL 5KIRA 2BMGA 3FCSB 1COUA 3ENSA 1IQLL 1URKA 1YUKB 1LPGA 4RUTA 4Y6DB 1N1IA 5EGMB 4ISIL 3GCXE 4D0FA 3SOVA 4RRZA 2EI7B 2PUQL 3N8YB 3ZYJB 4MMXB 1OB1C 3ZYIB 1LPKA 4BTTA 1U67A 1ATEA 4LMFA 1JV2B 2DDUA 3LC3B 1DDXA 2WPIE 4CSYA 3H5CB 3U73A 2F9BL 2WG3C 5L2YL 1F0RB 2Y82B 2ADXA 2B7DL 5IKTA 2P93L 1G1TA 2VJ3A 2P3FL 1YUGA 1NFWB 2W2ME 2K2SB 1W8BL 2P3FN 2RA0L 1O5DL 1F7EA 1G2LB 1U8CB 5JB8E 3K9XA 5JBAE 3IJEB 4ZXYL 1NFXB 1WHFA 4BTIA 3FFGL 3BPSE 2VWMK 5JBBE 4A7IA 1IGZA 1ATBA 3SOBB 4JYUL 4O02B 2J94B 2W3IB 3F1SB 2W2NE 1IP0A 4JZEL 2YGPA 3HS7A 3CENL 1NT0A 5E8DA 5JB9E 4TGFA 1DVAL 4XL1A 1IGXA 1WU1B 1X7AL 2P95L 5CKMA 1XDTR 2VVCK 1XKAL 1A3PA 2WG4B 1P0SL 1LQDA 3PGHA 3HPTA 2I9AA 1APQA 4YT6L 2WFTA 1F0SB 4X8TL 3KQEL 4Z6AL 3IITB 3N8YA 2BO2A 2BZ6L 2XBWL 1G1SA 1ZAQA 2KV4A 1NFYB 1Z6CA 4RRXA 4BXWA 4O1ZA 2Y80B 4G1MB 2P26A 2BOKL 1PGEA 3LN0A 2Q1JB 5COXA 1P9JA 3NJPC 4ISHL 4ZAEB 1HX2A 3ELAL 3HO5A 2BQWA 2G00L 1IQKL 1G2MB 2WPKE 3QCWA 2I9BA 2W86A 3F6UL 2Y38A 2PHBB 2RHPA 3QMOA 2FLRL 1EBVA 2XBVL 2Y5GL 1IVOC 3Q3KB 1Q4GA 2BQ7A 5CKNA 1FSBA 3TH3L 5L2ZL 4Y71B 3N8ZA 2CJIB 3HS5A 1LMJA 4RRYA 1NPEB 1PXXA 2WPJE 2FD6A 1IQFL 1DX5I 1EAIC 2KL7A 4FM5A 5L30L 4CUFA 2OYUP 2Y5HL 2UWPB 4X8SL 1KLJL 2VH6B 4NA9L 1TOZA 3MQEA 4BXSA 5JBCE 1N7DA 2W26B 4OTJA 2H9EL 4BTUA 5JVZA 1YO8A 2TGFA 1M1XB 2WYGB 1DQBA 1PRHA 1YUFA 3QH0A 3V64C 1CQEA 2VWOL 1PFXL 1UZPA 1CVWL 2GD4A 3M37L 1EMOA 3BT2A 4ZH8B 1FF7A 1FE2A 5CKQA 1EPHA 1MOXC 3ZYGA 1GK5A 1CVUA 4JZDL 5F1AA 1HREA 3MDLA 5JW1A 3KQCL 5IKQA 3V65B 1FFMA
chains in the Genus database with same CATH superfamily
2P3UA 3KL6B 5IKRA 3KQBL 1AUTL 1QIUA 1WHEA 2J38B 1MQ6L 4Y7AB 1EGFA 4JYVL 5FDQA 4XBMA 4XLWA 1HRFA 1HCGB 4Y79B 1NQLB 4PH9A 1HZ8A 4AQTA 2Y7ZB 1TPGA 1HAEA 1BF9A 2PR3B 2FZZL 4Y76B 2XBXL 1UZQA 4CUDA 3EGFA 2XC0L 2P94L 2FLGA 3HO3A 4D0EA 3LTGD 2EI6B 4MMYB 1IOEL 1CCFA 4X8VL 1IQIL 4LORA 1XFEA 1J9CL 3LN1A 3CFWA 1EPIA 2Y5FL 1NZIA 2Y7XB 1IJQA 3TZIA 1FAXL 2W2QE 2P28B 4YT7L 3GCWE 2W3KB 1HJ7A 3TBDA 3KK6A 1MQ5L 4C16A 5K0HB 1PTHA 2J4IB 1EPGA 1EMNA 5IKVA 3KCGL 4NG9L 3ASIA 1CEJA 1IQJL 3RR3A 2P16L 3TK6B 2WFXB 2WPME 3C9AC 4JZFL 1EQGA 1NFUB 4Z0KB 1LK9A 1HT5A 4MMZB 2J34B 1IOXA 1EZQB 1JBUL 2WPHE 4RRWA 3N8VA 1IQHL 4X8UL 3HS6A 2UWLB 5CISA 2D1JB 2BOUA 3BT1A 1JL9A 3POYA 5I46L 1ADXA 1HAFA 2J2UB 4ZXXL 3OLTA 3GISX 3KRKA 2W2PE 6COXA 1EPJA 3N8WB 3LIWB 1YGCL 1KLOA 3R05A 1C5MF 2KB9A 1APOA 1UZKA 2VVUL 3NTGA 2XC4L 2WPLE 1FJSL 1V1HA 1KSNB 1DIYA 3CA7A 1ATAA 2VVVL 2MGPA 1XKBA 1I0UA 1UZJA 4RS0A 3LTFB 2BOHA 2J95B 3P5BL 4YZUB 1IQEL 1FAKL 1QFKL 2AYLA 1IQGL 1KIGL 1K37A 1CX2A 2OYEP 2VWLL 1G1QA 1F7MA 2NPRA 1HT8A 3HO4A 4A94C 4E1GA 3DEMA 1EQHA 3LAQA 2W2OE 3Q7DA 4CUEA 5F19A 2MGRA 3CS7L 2XC5L 1K36A 2VWNL 2H9EC 1ATDA 2K2TA 2M74A 1V3XB 3LC5B 1KLIL 2Y81B 2VRSA 4BDXA 1L3YA 2WYJB 1IQML 1W7XL 1G1RA 4NGAL 3TGFA 2P3TA 2BOXA 4BDWA 5KN5C 3FBYA 3KQDL 4M10A 1TLEA 3N8XA 4M11A 1B9WA 2FLBL 4Y7BB 1Z6EL 4ZHAB 3OLUA 4GU4A 4Z0LA 1CCVA 1LMMA 4COXA 2VH0B 2WZPP 5JVYA 1LPZA 3SW2A 3SOQA 2XBYL 1SZBA 2BQ6A 2RNLA 2YGOA 2EI8B 1L5GB 2UWOB 1V1IA 3N8WA 2JKHL 3U7UG 3NTBA 4OTYA 3M36L 3TK5B 2MHPA 3NT1A 4D90A 1RFNB 1IQNL 5KIRA 2BMGA 3FCSB 1COUA 3ENSA 1IQLL 1URKA 1YUKB 1LPGA 2BT7A 4RUTA 4Y6DB 1N1IA 5EGMB 4ISIL 3GCXE 4D0FA 3SOVA 4RRZA 2EI7B 2PUQL 3N8YB 3ZYJB 4MMXB 1OB1C 3ZYIB 1LPKA 4BTTA 1U67A 1ATEA 4LMFA 1JV2B 2DDUA 3LC3B 1DDXA 2WPIE 4CSYA 3H5CB 3U73A 2F9BL 2WG3C 5L2YL 1F0RB 2Y82B 2ADXA 2B7DL 5IKTA 2P93L 1G1TA 2VJ3A 2P3FL 1YUGA 1NFWB 2W2ME 2K2SB 1W8BL 2P3FN 2RA0L 1O5DL 1F7EA 1G2LB 1U8CB 5JB8E 3K9XA 5JBAE 3IJEB 4ZXYL 1NFXB 1WHFA 4BTIA 3FFGL 3BPSE 2VWMK 5JBBE 4A7IA 1IGZA 1ATBA 3SOBB 4JYUL 4O02B 2J94B 2W3IB 3F1SB 2W2NE 1IP0A 4JZEL 2YGPA 3HS7A 3CENL 1NT0A 5E8DA 5JB9E 4TGFA 1DVAL 4XL1A 1IGXA 1WU1B 1X7AL 2P95L 5CKMA 1XDTR 2VVCK 1XKAL 1A3PA 2WG4B 1P0SL 1LQDA 3PGHA 3HPTA 2I9AA 1APQA 4YT6L 2WFTA 2KNIA 1F0SB 4X8TL 3KQEL 4Z6AL 3IITB 3N8YA 2HOXA 2BO2A 2BZ6L 2XBWL 1G1SA 1ZAQA 2KV4A 1NFYB 1Z6CA 4RRXA 4BXWA 4O1ZA 2Y80B 4G1MB 2P26A 2BOKL 1PGEA 3LN0A 2Q1JB 5COXA 1P9JA 3NJPC 4ISHL 4ZAEB 1HX2A 3ELAL 3HO5A 2BQWA 2G00L 1IQKL 1G2MB 2WPKE 3QCWA 2I9BA 2W86A 3F6UL 2Y38A 2PHBB 2RHPA 3QMOA 2FLRL 1EBVA 2XBVL 2Y5GL 1IVOC 3Q3KB 1Q4GA 2BQ7A 5CKNA 1FSBA 3TH3L 5L2ZL 2JJLA 4Y71B 3N8ZA 2CJIB 3HS5A 1LMJA 4RRYA 1KKEA 1NPEB 1PXXA 2WPJE 2FD6A 1IQFL 2YGQA 1DX5I 1EAIC 2KL7A 4FM5A 5L30L 4CUFA 2OYUP 2BT8A 2Y5HL 4GU3A 2UWPB 4X8SL 1KLJL 2BSFA 2VH6B 4NA9L 1TOZA 3MQEA 4BXSA 5JBCE 1N7DA 2W26B 4OTJA 2H9EL 4BTUA 5JVZA 1YO8A 2TGFA 1M1XB 2WYGB 1DQBA 1PRHA 1YUFA 3QH0A 3V64C 1CQEA 2VWOL 1PFXL 1UZPA 1CVWL 2GD4A 3M37L 1EMOA 3BT2A 4ZH8B 1FF7A 1FE2A 5CKQA 1EPHA 1MOXC 3ZYGA 1GK5A 1CVUA 4JZDL 3S6XA 5F1AA 2HORA 1HREA 3MDLA 5JW1A 3KQCL 5IKQA 3V65B 1FFMA
chains in the Genus database with same CATH topology
2P3UA 3KL6B 5IKRA 3KQBL 1AUTL 1WHEA 2J38B 1MQ6L 4Y7AB 1EGFA 4JYVL 5FDQA 4XBMA 4XLWA 1HRFA 1HCGB 4Y79B 1NQLB 4PH9A 1HZ8A 4AQTA 2Y7ZB 1TPGA 1HAEA 1BF9A 2PR3B 2FZZL 4Y76B 2XBXL 1UZQA 4CUDA 3EGFA 2XC0L 2P94L 2FLGA 3HO3A 4D0EA 3LTGD 2EI6B 4MMYB 1IOEL 1CCFA 4X8VL 1IQIL 4LORA 1XFEA 1J9CL 3LN1A 3CFWA 1EPIA 2Y5FL 1NZIA 2Y7XB 1IJQA 3TZIA 1FAXL 2W2QE 2P28B 4YT7L 3GCWE 2W3KB 1HJ7A 3TBDA 3KK6A 1MQ5L 4C16A 5K0HB 1PTHA 2J4IB 1EPGA 1EMNA 5IKVA 3KCGL 4NG9L 3ASIA 1CEJA 1IQJL 3RR3A 2P16L 3TK6B 2WFXB 2WPME 3C9AC 4JZFL 1EQGA 1NFUB 4Z0KB 1HT5A 4MMZB 2J34B 1IOXA 1EZQB 1JBUL 2WPHE 4RRWA 3N8VA 1IQHL 4X8UL 3HS6A 2UWLB 5CISA 2D1JB 2BOUA 3BT1A 1JL9A 3POYA 5I46L 1ADXA 1HAFA 2J2UB 4ZXXL 3OLTA 3GISX 3KRKA 2W2PE 6COXA 1EPJA 3N8WB 3LIWB 1YGCL 1KLOA 3R05A 1C5MF 2KB9A 1APOA 1UZKA 2VVUL 3NTGA 2XC4L 2WPLE 1FJSL 1KSNB 1DIYA 3CA7A 1ATAA 2MGPA 2VVVL 1XKBA 1I0UA 1UZJA 4RS0A 3LTFB 2BOHA 2J95B 3P5BL 4YZUB 1IQEL 1FAKL 1QFKL 2AYLA 1IQGL 1KIGL 1K37A 1CX2A 2OYEP 2VWLL 1G1QA 1F7MA 2NPRA 1HT8A 3HO4A 4A94C 4E1GA 3DEMA 1EQHA 3LAQA 2W2OE 3Q7DA 4CUEA 5F19A 2MGRA 3CS7L 2XC5L 1K36A 2VWNL 2H9EC 1ATDA 2K2TA 2M74A 1V3XB 3LC5B 1KLIL 2Y81B 4BDXA 1L3YA 2WYJB 1IQML 1W7XL 1G1RA 4NGAL 3TGFA 2P3TA 2BOXA 4BDWA 5KN5C 3FBYA 3KQDL 4M10A 1TLEA 3N8XA 4M11A 1B9WA 2FLBL 4Y7BB 1Z6EL 4ZHAB 3OLUA 4Z0LA 1CCVA 1LMMA 4COXA 2VH0B 2WZPP 5JVYA 1LPZA 3SW2A 3SOQA 2XBYL 1SZBA 2BQ6A 2RNLA 2YGOA 2EI8B 1L5GB 2UWOB 3N8WA 2JKHL 3U7UG 3NTBA 4OTYA 3M36L 3TK5B 2MHPA 3NT1A 4D90A 1RFNB 1IQNL 5KIRA 2BMGA 3FCSB 1COUA 3ENSA 1IQLL 1URKA 1YUKB 1LPGA 4RUTA 4Y6DB 1N1IA 5EGMB 4ISIL 3GCXE 4D0FA 3SOVA 4RRZA 2EI7B 2PUQL 3N8YB 3ZYJB 4MMXB 1OB1C 3ZYIB 1LPKA 4BTTA 1U67A 1ATEA 4LMFA 1JV2B 2DDUA 3LC3B 1DDXA 2WPIE 4CSYA 3H5CB 3U73A 2F9BL 2WG3C 5L2YL 1F0RB 2Y82B 2ADXA 2B7DL 5IKTA 2P93L 1G1TA 2VJ3A 2P3FL 1YUGA 1NFWB 2W2ME 2K2SB 1W8BL 2P3FN 2RA0L 1O5DL 1F7EA 1G2LB 1U8CB 5JB8E 3K9XA 5JBAE 3IJEB 4ZXYL 1NFXB 1WHFA 4BTIA 3FFGL 3BPSE 2VWMK 5JBBE 4A7IA 1IGZA 1ATBA 3SOBB 4JYUL 4O02B 2J94B 2W3IB 3F1SB 2W2NE 1IP0A 4JZEL 2YGPA 3HS7A 3CENL 1NT0A 5E8DA 5JB9E 4TGFA 1DVAL 4XL1A 1IGXA 1WU1B 1X7AL 2P95L 5CKMA 1XDTR 2VVCK 1XKAL 1A3PA 2WG4B 1P0SL 1LQDA 3PGHA 3HPTA 2I9AA 1APQA 4YT6L 2WFTA 2KNIA 1F0SB 4X8TL 3KQEL 4Z6AL 3IITB 3N8YA 2BO2A 2BZ6L 2XBWL 1G1SA 1ZAQA 2KV4A 1NFYB 1Z6CA 4RRXA 4BXWA 4O1ZA 2Y80B 4G1MB 2P26A 2BOKL 1PGEA 3LN0A 2Q1JB 5COXA 1P9JA 3NJPC 4ISHL 4ZAEB 1HX2A 3ELAL 3HO5A 2BQWA 2G00L 1IQKL 1G2MB 2WPKE 3QCWA 2I9BA 2W86A 3F6UL 2Y38A 2PHBB 2RHPA 3QMOA 2FLRL 1EBVA 2XBVL 2Y5GL 1IVOC 3Q3KB 1Q4GA 2BQ7A 5CKNA 1FSBA 3TH3L 5L2ZL 4Y71B 3N8ZA 2CJIB 3HS5A 1LMJA 4RRYA 1NPEB 1PXXA 2WPJE 2FD6A 1IQFL 2YGQA 1DX5I 1EAIC 2KL7A 4FM5A 5L30L 4CUFA 2OYUP 2Y5HL 2UWPB 4X8SL 1KLJL 2VH6B 4NA9L 1TOZA 3MQEA 4BXSA 5JBCE 1N7DA 2W26B 4OTJA 2H9EL 4BTUA 5JVZA 1YO8A 2TGFA 1M1XB 2WYGB 1DQBA 1PRHA 1YUFA 3QH0A 3V64C 1CQEA 2VWOL 1PFXL 1UZPA 1CVWL 2GD4A 3M37L 1EMOA 3BT2A 4ZH8B 1FF7A 1FE2A 5CKQA 1EPHA 1MOXC 3ZYGA 1GK5A 1CVUA 4JZDL 3S6XA 5F1AA 1HREA 3MDLA 5JW1A 3KQCL 5IKQA 3V65B 1FFMA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2P3U A;  3KL6 B;  5IKR A;  3KQB L;  1AUT L;  1WHE A;  2J38 B;  1MQ6 L;  4Y7A B;  1EGF A;  4JYV L;  5FDQ A;  4XBM A;  4XLW A;  1HRF A;  1HCG B;  4Y79 B;  1NQL B;  4PH9 A;  1HZ8 A;  4AQT A;  2Y7Z B;  1TPG A;  1HAE A;  1BF9 A;  2PR3 B;  2FZZ L;  4Y76 B;  2XBX L;  1UZQ A;  4CUD A;  3EGF A;  2XC0 L;  2P94 L;  2FLG A;  3HO3 A;  4D0E A;  3LTG D;  2EI6 B;  4MMY B;  1IOE L;  1CCF A;  4X8V L;  1IQI L;  4LOR A;  1XFE A;  1J9C L;  3LN1 A;  3CFW A;  1EPI A;  2Y5F L;  1NZI A;  2Y7X B;  1IJQ A;  3TZI A;  1FAX L;  2W2Q E;  2P28 B;  4YT7 L;  3GCW E;  2W3K B;  1HJ7 A;  3TBD A;  3KK6 A;  1MQ5 L;  4C16 A;  5K0H B;  1PTH A;  2J4I B;  1EPG A;  1EMN A;  5IKV A;  3KCG L;  4NG9 L;  3ASI A;  1CEJ A;  1IQJ L;  3RR3 A;  2P16 L;  3TK6 B;  2WFX B;  2WPM E;  3C9A C;  4JZF L;  1EQG A;  1NFU B;  4Z0K B;  1HT5 A;  4MMZ B;  2J34 B;  1IOX A;  1EZQ B;  1JBU L;  2WPH E;  4RRW A;  3N8V A;  1IQH L;  4X8U L;  3HS6 A;  2UWL B;  5CIS A;  2D1J B;  2BOU A;  3BT1 A;  1JL9 A;  3POY A;  5I46 L;  1ADX A;  1HAF A;  2J2U B;  4ZXX L;  3OLT A;  3GIS X;  3KRK A;  2W2P E;  6COX A;  1EPJ A;  3N8W B;  3LIW B;  1YGC L;  1KLO A;  3R05 A;  1C5M F;  2KB9 A;  1APO A;  1UZK A;  2VVU L;  3NTG A;  2XC4 L;  2WPL E;  1FJS L;  1KSN B;  1DIY A;  3CA7 A;  1ATA A;  2MGP A;  2VVV L;  1XKB A;  1I0U A;  1UZJ A;  4RS0 A;  3LTF B;  2BOH A;  2J95 B;  3P5B L;  4YZU B;  1IQE L;  1FAK L;  1QFK L;  2AYL A;  1IQG L;  1KIG L;  1K37 A;  1CX2 A;  2OYE P;  2VWL L;  1G1Q A;  1F7M A;  2NPR A;  1HT8 A;  3HO4 A;  4E1G A;  3DEM A;  1EQH A;  3LAQ A;  2W2O E;  3Q7D A;  4CUE A;  5F19 A;  2MGR A;  3CS7 L;  2XC5 L;  1K36 A;  2VWN L;  1ATD A;  2K2T A;  2M74 A;  1V3X B;  3LC5 B;  1KLI L;  2Y81 B;  4BDX A;  1L3Y A;  2WYJ B;  1IQM L;  1W7X L;  1G1R A;  4NGA L;  3TGF A;  2P3T A;  2BOX A;  4BDW A;  5KN5 C;  3FBY A;  3KQD L;  4M10 A;  1TLE A;  3N8X A;  4M11 A;  1B9W A;  2FLB L;  4Y7B B;  1Z6E L;  4ZHA B;  3OLU A;  4Z0L A;  1CCV A;  4COX A;  2VH0 B;  5JVY A;  1LPZ A;  3SW2 A;  3SOQ A;  2XBY L;  1SZB A;  2BQ6 A;  2RNL A;  2YGO A;  2EI8 B;  1L5G B;  2UWO B;  3N8W A;  2JKH L;  3U7U G;  3NTB A;  4OTY A;  3M36 L;  3TK5 B;  2MHP A;  3NT1 A;  4D90 A;  1RFN B;  1IQN L;  5KIR A;  2BMG A;  3FCS B;  1COU A;  3ENS A;  1IQL L;  1URK A;  1YUK B;  1LPG A;  4RUT A;  4Y6D B;  1N1I A;  5EGM B;  4ISI L;  3GCX E;  4D0F A;  3SOV A;  4RRZ A;  2EI7 B;  2PUQ L;  3N8Y B;  3ZYJ B;  4MMX B;  1OB1 C;  3ZYI B;  1LPK A;  4BTT A;  1U67 A;  1ATE A;  4LMF A;  1JV2 B;  2DDU A;  3LC3 B;  1DDX A;  2WPI E;  4CSY A;  3H5C B;  3U73 A;  2F9B L;  2WG3 C;  5L2Y L;  1F0R B;  2Y82 B;  2ADX A;  2B7D L;  5IKT A;  2P93 L;  1G1T A;  2VJ3 A;  2P3F L;  1YUG A;  1NFW B;  2W2M E;  2K2S B;  1W8B L;  2P3F N;  2RA0 L;  1O5D L;  1F7E A;  1G2L B;  1U8C B;  5JB8 E;  3K9X A;  5JBA E;  3IJE B;  4ZXY L;  1NFX B;  1WHF A;  4BTI A;  3FFG L;  3BPS E;  2VWM K;  5JBB E;  4A7I A;  1IGZ A;  1ATB A;  3SOB B;  4JYU L;  4O02 B;  2J94 B;  2W3I B;  3F1S B;  2W2N E;  1IP0 A;  4JZE L;  2YGP A;  3HS7 A;  3CEN L;  1NT0 A;  5E8D A;  5JB9 E;  4TGF A;  1DVA L;  4XL1 A;  1IGX A;  1WU1 B;  1X7A L;  2P95 L;  5CKM A;  1XDT R;  2VVC K;  1XKA L;  1A3P A;  2WG4 B;  1P0S L;  1LQD A;  3PGH A;  3HPT A;  2I9A A;  1APQ A;  4YT6 L;  2WFT A;  1F0S B;  4X8T L;  3KQE L;  4Z6A L;  3IIT B;  3N8Y A;  2BO2 A;  2BZ6 L;  2XBW L;  1G1S A;  1ZAQ A;  2KV4 A;  1NFY B;  1Z6C A;  4RRX A;  4BXW A;  4O1Z A;  2Y80 B;  4G1M B;  2P26 A;  2BOK L;  1PGE A;  3LN0 A;  2Q1J B;  5COX A;  1P9J A;  3NJP C;  4ISH L;  4ZAE B;  1HX2 A;  3ELA L;  3HO5 A;  2BQW A;  2G00 L;  1IQK L;  1G2M B;  2WPK E;  3QCW A;  2I9B A;  2W86 A;  3F6U L;  2Y38 A;  2PHB B;  2RHP A;  3QMO A;  2FLR L;  1EBV A;  2XBV L;  2Y5G L;  1IVO C;  3Q3K B;  1Q4G A;  2BQ7 A;  5CKN A;  1FSB A;  3TH3 L;  5L2Z L;  4Y71 B;  3N8Z A;  2CJI B;  3HS5 A;  1LMJ A;  4RRY A;  1NPE B;  1PXX A;  2WPJ E;  2FD6 A;  1IQF L;  1DX5 I;  1EAI C;  2KL7 A;  4FM5 A;  5L30 L;  4CUF A;  2OYU P;  2Y5H L;  2UWP B;  4X8S L;  1KLJ L;  2VH6 B;  4NA9 L;  1TOZ A;  3MQE A;  4BXS A;  5JBC E;  1N7D A;  2W26 B;  4OTJ A;  2H9E L;  4BTU A;  5JVZ A;  1YO8 A;  2TGF A;  1M1X B;  2WYG B;  1DQB A;  1PRH A;  1YUF A;  3QH0 A;  3V64 C;  1CQE A;  2VWO L;  1PFX L;  1UZP A;  1CVW L;  2GD4 A;  3M37 L;  1EMO A;  3BT2 A;  4ZH8 B;  1FF7 A;  1FE2 A;  5CKQ A;  1EPH A;  1MOX C;  3ZYG A;  1GK5 A;  1CVU A;  4JZD L;  5F1A A;  1HRE A;  3MDL A;  5JW1 A;  3KQC L;  5IKQ A;  3V65 B;  1FFM A; 
#chains in the Genus database with same CATH topology
 2P3U A;  3KL6 B;  5IKR A;  3KQB L;  1AUT L;  1QIU A;  1WHE A;  2J38 B;  1MQ6 L;  4Y7A B;  1EGF A;  4JYV L;  5FDQ A;  4XBM A;  4XLW A;  1HRF A;  1HCG B;  4Y79 B;  1NQL B;  4PH9 A;  1HZ8 A;  4AQT A;  2Y7Z B;  1TPG A;  1HAE A;  1BF9 A;  2PR3 B;  2FZZ L;  4Y76 B;  2XBX L;  1UZQ A;  4CUD A;  3EGF A;  2XC0 L;  2P94 L;  2FLG A;  3HO3 A;  4D0E A;  3LTG D;  2EI6 B;  4MMY B;  1IOE L;  1CCF A;  4X8V L;  1IQI L;  4LOR A;  1XFE A;  1J9C L;  3LN1 A;  3CFW A;  1EPI A;  2Y5F L;  1NZI A;  2Y7X B;  1IJQ A;  3TZI A;  1FAX L;  2W2Q E;  2P28 B;  4YT7 L;  3GCW E;  2W3K B;  1HJ7 A;  3TBD A;  3KK6 A;  1MQ5 L;  4C16 A;  5K0H B;  1PTH A;  2J4I B;  1EPG A;  1EMN A;  5IKV A;  3KCG L;  4NG9 L;  3ASI A;  1CEJ A;  1IQJ L;  3RR3 A;  2P16 L;  3TK6 B;  2WFX B;  2WPM E;  3C9A C;  4JZF L;  1EQG A;  1NFU B;  4Z0K B;  1LK9 A;  1HT5 A;  4MMZ B;  2J34 B;  1IOX A;  1EZQ B;  1JBU L;  2WPH E;  4RRW A;  3N8V A;  1IQH L;  4X8U L;  3HS6 A;  2UWL B;  5CIS A;  2D1J B;  2BOU A;  3BT1 A;  1JL9 A;  3POY A;  5I46 L;  1ADX A;  1HAF A;  2J2U B;  4ZXX L;  3OLT A;  3GIS X;  3KRK A;  2W2P E;  6COX A;  1EPJ A;  3N8W B;  3LIW B;  1YGC L;  1KLO A;  3R05 A;  1C5M F;  2KB9 A;  1APO A;  1UZK A;  2VVU L;  3NTG A;  2XC4 L;  2WPL E;  1FJS L;  1V1H A;  1KSN B;  1DIY A;  3CA7 A;  1ATA A;  2VVV L;  2MGP A;  1XKB A;  1I0U A;  1UZJ A;  4RS0 A;  3LTF B;  2BOH A;  2J95 B;  3P5B L;  4YZU B;  1IQE L;  1FAK L;  1QFK L;  2AYL A;  1IQG L;  1KIG L;  1K37 A;  1CX2 A;  2OYE P;  2VWL L;  1G1Q A;  1F7M A;  2NPR A;  1HT8 A;  3HO4 A;  4A94 C;  4E1G A;  3DEM A;  1EQH A;  3LAQ A;  2W2O E;  3Q7D A;  4CUE A;  5F19 A;  2MGR A;  3CS7 L;  2XC5 L;  1K36 A;  2VWN L;  2H9E C;  1ATD A;  2K2T A;  2M74 A;  1V3X B;  3LC5 B;  1KLI L;  2Y81 B;  2VRS A;  4BDX A;  1L3Y A;  2WYJ B;  1IQM L;  1W7X L;  1G1R A;  4NGA L;  3TGF A;  2P3T A;  2BOX A;  4BDW A;  5KN5 C;  3FBY A;  3KQD L;  4M10 A;  1TLE A;  3N8X A;  4M11 A;  1B9W A;  2FLB L;  4Y7B B;  1Z6E L;  4ZHA B;  3OLU A;  4GU4 A;  4Z0L A;  1CCV A;  1LMM A;  4COX A;  2VH0 B;  2WZP P;  5JVY A;  1LPZ A;  3SW2 A;  3SOQ A;  2XBY L;  1SZB A;  2BQ6 A;  2RNL A;  2YGO A;  2EI8 B;  1L5G B;  2UWO B;  1V1I A;  3N8W A;  2JKH L;  3U7U G;  3NTB A;  4OTY A;  3M36 L;  3TK5 B;  2MHP A;  3NT1 A;  4D90 A;  1RFN B;  1IQN L;  5KIR A;  2BMG A;  3FCS B;  1COU A;  3ENS A;  1IQL L;  1URK A;  1YUK B;  1LPG A;  2BT7 A;  4RUT A;  4Y6D B;  1N1I A;  5EGM B;  4ISI L;  3GCX E;  4D0F A;  3SOV A;  4RRZ A;  2EI7 B;  2PUQ L;  3N8Y B;  3ZYJ B;  4MMX B;  1OB1 C;  3ZYI B;  1LPK A;  4BTT A;  1U67 A;  1ATE A;  4LMF A;  1JV2 B;  2DDU A;  3LC3 B;  1DDX A;  2WPI E;  4CSY A;  3H5C B;  3U73 A;  2F9B L;  2WG3 C;  5L2Y L;  1F0R B;  2Y82 B;  2ADX A;  2B7D L;  5IKT A;  2P93 L;  1G1T A;  2VJ3 A;  2P3F L;  1YUG A;  1NFW B;  2W2M E;  2K2S B;  1W8B L;  2P3F N;  2RA0 L;  1O5D L;  1F7E A;  1G2L B;  1U8C B;  5JB8 E;  3K9X A;  5JBA E;  3IJE B;  4ZXY L;  1NFX B;  1WHF A;  4BTI A;  3FFG L;  3BPS E;  2VWM K;  5JBB E;  4A7I A;  1IGZ A;  1ATB A;  3SOB B;  4JYU L;  4O02 B;  2J94 B;  2W3I B;  3F1S B;  2W2N E;  1IP0 A;  4JZE L;  2YGP A;  3HS7 A;  3CEN L;  1NT0 A;  5E8D A;  5JB9 E;  4TGF A;  1DVA L;  4XL1 A;  1IGX A;  1WU1 B;  1X7A L;  2P95 L;  5CKM A;  1XDT R;  2VVC K;  1XKA L;  1A3P A;  2WG4 B;  1P0S L;  1LQD A;  3PGH A;  3HPT A;  2I9A A;  1APQ A;  4YT6 L;  2WFT A;  2KNI A;  1F0S B;  4X8T L;  3KQE L;  4Z6A L;  3IIT B;  3N8Y A;  2HOX A;  2BO2 A;  2BZ6 L;  2XBW L;  1G1S A;  1ZAQ A;  2KV4 A;  1NFY B;  1Z6C A;  4RRX A;  4BXW A;  4O1Z A;  2Y80 B;  4G1M B;  2P26 A;  2BOK L;  1PGE A;  3LN0 A;  2Q1J B;  5COX A;  1P9J A;  3NJP C;  4ISH L;  4ZAE B;  1HX2 A;  3ELA L;  3HO5 A;  2BQW A;  2G00 L;  1IQK L;  1G2M B;  2WPK E;  3QCW A;  2I9B A;  2W86 A;  3F6U L;  2Y38 A;  2PHB B;  2RHP A;  3QMO A;  2FLR L;  1EBV A;  2XBV L;  2Y5G L;  1IVO C;  3Q3K B;  1Q4G A;  2BQ7 A;  5CKN A;  1FSB A;  3TH3 L;  5L2Z L;  2JJL A;  4Y71 B;  3N8Z A;  2CJI B;  3HS5 A;  1LMJ A;  4RRY A;  1KKE A;  1NPE B;  1PXX A;  2WPJ E;  2FD6 A;  1IQF L;  2YGQ A;  1DX5 I;  1EAI C;  2KL7 A;  4FM5 A;  5L30 L;  4CUF A;  2OYU P;  2BT8 A;  2Y5H L;  4GU3 A;  2UWP B;  4X8S L;  1KLJ L;  2BSF A;  2VH6 B;  4NA9 L;  1TOZ A;  3MQE A;  4BXS A;  5JBC E;  1N7D A;  2W26 B;  4OTJ A;  2H9E L;  4BTU A;  5JVZ A;  1YO8 A;  2TGF A;  1M1X B;  2WYG B;  1DQB A;  1PRH A;  1YUF A;  3QH0 A;  3V64 C;  1CQE A;  2VWO L;  1PFX L;  1UZP A;  1CVW L;  2GD4 A;  3M37 L;  1EMO A;  3BT2 A;  4ZH8 B;  1FF7 A;  1FE2 A;  5CKQ A;  1EPH A;  1MOX C;  3ZYG A;  1GK5 A;  1CVU A;  4JZD L;  3S6X A;  5F1A A;  2HOR A;  1HRE A;  3MDL A;  5JW1 A;  3KQC L;  5IKQ A;  3V65 B;  1FFM A; 
#chains in the Genus database with same CATH homology
 2P3U A;  3KL6 B;  5IKR A;  3KQB L;  1AUT L;  1WHE A;  2J38 B;  1MQ6 L;  4Y7A B;  1EGF A;  4JYV L;  5FDQ A;  4XBM A;  4XLW A;  1HRF A;  1HCG B;  4Y79 B;  1NQL B;  4PH9 A;  1HZ8 A;  4AQT A;  2Y7Z B;  1TPG A;  1HAE A;  1BF9 A;  2PR3 B;  2FZZ L;  4Y76 B;  2XBX L;  1UZQ A;  4CUD A;  3EGF A;  2XC0 L;  2P94 L;  2FLG A;  3HO3 A;  4D0E A;  3LTG D;  2EI6 B;  4MMY B;  1IOE L;  1CCF A;  4X8V L;  1IQI L;  4LOR A;  1XFE A;  1J9C L;  3LN1 A;  3CFW A;  1EPI A;  2Y5F L;  1NZI A;  2Y7X B;  1IJQ A;  3TZI A;  1FAX L;  2W2Q E;  2P28 B;  4YT7 L;  3GCW E;  2W3K B;  1HJ7 A;  3TBD A;  3KK6 A;  1MQ5 L;  4C16 A;  5K0H B;  1PTH A;  2J4I B;  1EPG A;  1EMN A;  5IKV A;  3KCG L;  4NG9 L;  3ASI A;  1CEJ A;  1IQJ L;  3RR3 A;  2P16 L;  3TK6 B;  2WFX B;  2WPM E;  3C9A C;  4JZF L;  1EQG A;  1NFU B;  4Z0K B;  1HT5 A;  4MMZ B;  2J34 B;  1IOX A;  1EZQ B;  1JBU L;  2WPH E;  4RRW A;  3N8V A;  1IQH L;  4X8U L;  3HS6 A;  2UWL B;  5CIS A;  2D1J B;  2BOU A;  3BT1 A;  1JL9 A;  3POY A;  5I46 L;  1ADX A;  1HAF A;  2J2U B;  4ZXX L;  3OLT A;  3GIS X;  3KRK A;  2W2P E;  6COX A;  1EPJ A;  3N8W B;  3LIW B;  1YGC L;  1KLO A;  3R05 A;  1C5M F;  2KB9 A;  1APO A;  1UZK A;  2VVU L;  3NTG A;  2XC4 L;  2WPL E;  1FJS L;  1KSN B;  1DIY A;  3CA7 A;  1ATA A;  2MGP A;  2VVV L;  1XKB A;  1I0U A;  1UZJ A;  4RS0 A;  3LTF B;  2BOH A;  2J95 B;  3P5B L;  4YZU B;  1IQE L;  1FAK L;  1QFK L;  2AYL A;  1IQG L;  1KIG L;  1K37 A;  1CX2 A;  2OYE P;  2VWL L;  1G1Q A;  1F7M A;  2NPR A;  1HT8 A;  3HO4 A;  4A94 C;  4E1G A;  3DEM A;  1EQH A;  3LAQ A;  2W2O E;  3Q7D A;  4CUE A;  5F19 A;  2MGR A;  3CS7 L;  2XC5 L;  1K36 A;  2VWN L;  2H9E C;  1ATD A;  2K2T A;  2M74 A;  1V3X B;  3LC5 B;  1KLI L;  2Y81 B;  4BDX A;  1L3Y A;  2WYJ B;  1IQM L;  1W7X L;  1G1R A;  4NGA L;  3TGF A;  2P3T A;  2BOX A;  4BDW A;  5KN5 C;  3FBY A;  3KQD L;  4M10 A;  1TLE A;  3N8X A;  4M11 A;  1B9W A;  2FLB L;  4Y7B B;  1Z6E L;  4ZHA B;  3OLU A;  4Z0L A;  1CCV A;  1LMM A;  4COX A;  2VH0 B;  2WZP P;  5JVY A;  1LPZ A;  3SW2 A;  3SOQ A;  2XBY L;  1SZB A;  2BQ6 A;  2RNL A;  2YGO A;  2EI8 B;  1L5G B;  2UWO B;  3N8W A;  2JKH L;  3U7U G;  3NTB A;  4OTY A;  3M36 L;  3TK5 B;  2MHP A;  3NT1 A;  4D90 A;  1RFN B;  1IQN L;  5KIR A;  2BMG A;  3FCS B;  1COU A;  3ENS A;  1IQL L;  1URK A;  1YUK B;  1LPG A;  4RUT A;  4Y6D B;  1N1I A;  5EGM B;  4ISI L;  3GCX E;  4D0F A;  3SOV A;  4RRZ A;  2EI7 B;  2PUQ L;  3N8Y B;  3ZYJ B;  4MMX B;  1OB1 C;  3ZYI B;  1LPK A;  4BTT A;  1U67 A;  1ATE A;  4LMF A;  1JV2 B;  2DDU A;  3LC3 B;  1DDX A;  2WPI E;  4CSY A;  3H5C B;  3U73 A;  2F9B L;  2WG3 C;  5L2Y L;  1F0R B;  2Y82 B;  2ADX A;  2B7D L;  5IKT A;  2P93 L;  1G1T A;  2VJ3 A;  2P3F L;  1YUG A;  1NFW B;  2W2M E;  2K2S B;  1W8B L;  2P3F N;  2RA0 L;  1O5D L;  1F7E A;  1G2L B;  1U8C B;  5JB8 E;  3K9X A;  5JBA E;  3IJE B;  4ZXY L;  1NFX B;  1WHF A;  4BTI A;  3FFG L;  3BPS E;  2VWM K;  5JBB E;  4A7I A;  1IGZ A;  1ATB A;  3SOB B;  4JYU L;  4O02 B;  2J94 B;  2W3I B;  3F1S B;  2W2N E;  1IP0 A;  4JZE L;  2YGP A;  3HS7 A;  3CEN L;  1NT0 A;  5E8D A;  5JB9 E;  4TGF A;  1DVA L;  4XL1 A;  1IGX A;  1WU1 B;  1X7A L;  2P95 L;  5CKM A;  1XDT R;  2VVC K;  1XKA L;  1A3P A;  2WG4 B;  1P0S L;  1LQD A;  3PGH A;  3HPT A;  2I9A A;  1APQ A;  4YT6 L;  2WFT A;  2KNI A;  1F0S B;  4X8T L;  3KQE L;  4Z6A L;  3IIT B;  3N8Y A;  2BO2 A;  2BZ6 L;  2XBW L;  1G1S A;  1ZAQ A;  2KV4 A;  1NFY B;  1Z6C A;  4RRX A;  4BXW A;  4O1Z A;  2Y80 B;  4G1M B;  2P26 A;  2BOK L;  1PGE A;  3LN0 A;  2Q1J B;  5COX A;  1P9J A;  3NJP C;  4ISH L;  4ZAE B;  1HX2 A;  3ELA L;  3HO5 A;  2BQW A;  2G00 L;  1IQK L;  1G2M B;  2WPK E;  3QCW A;  2I9B A;  2W86 A;  3F6U L;  2Y38 A;  2PHB B;  2RHP A;  3QMO A;  2FLR L;  1EBV A;  2XBV L;  2Y5G L;  1IVO C;  3Q3K B;  1Q4G A;  2BQ7 A;  5CKN A;  1FSB A;  3TH3 L;  5L2Z L;  4Y71 B;  3N8Z A;  2CJI B;  3HS5 A;  1LMJ A;  4RRY A;  1NPE B;  1PXX A;  2WPJ E;  2FD6 A;  1IQF L;  2YGQ A;  1DX5 I;  1EAI C;  2KL7 A;  4FM5 A;  5L30 L;  4CUF A;  2OYU P;  2Y5H L;  2UWP B;  4X8S L;  1KLJ L;  2VH6 B;  4NA9 L;  1TOZ A;  3MQE A;  4BXS A;  5JBC E;  1N7D A;  2W26 B;  4OTJ A;  2H9E L;  4BTU A;  5JVZ A;  1YO8 A;  2TGF A;  1M1X B;  2WYG B;  1DQB A;  1PRH A;  1YUF A;  3QH0 A;  3V64 C;  1CQE A;  2VWO L;  1PFX L;  1UZP A;  1CVW L;  2GD4 A;  3M37 L;  1EMO A;  3BT2 A;  4ZH8 B;  1FF7 A;  1FE2 A;  5CKQ A;  1EPH A;  1MOX C;  3ZYG A;  1GK5 A;  1CVU A;  4JZD L;  3S6X A;  5F1A A;  1HRE A;  3MDL A;  5JW1 A;  3KQC L;  5IKQ A;  3V65 B;  1FFM A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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