3KL6B

Discovery of tetrahydropyrimidin-2(1h)-one derivative tak-442: a potent, selective and orally active factor xa inhibitor
Total Genus 12
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
12
sequence length
50
structure length
50
Chain Sequence
KLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQT
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Discovery of a tetrahydropyrimidin-2(1H)-one derivative (TAK-442) as a potent, selective, and orally active factor Xa inhibitor.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Coagulation Factor X heavy chain
total genus 12
structure length 50
sequence length 50
ec nomenclature ec 3.4.21.6: Coagulation factor Xa.
pdb deposition date 2009-11-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF14670 FXa_inhibition Coagulation Factor Xa inhibitory site
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.25.10 Mainly Beta Ribbon Laminin Laminin 3kl6B00
4ZAEB 1P0SL 3ZYGA 3SOVA 3NT1A 3Q7DA 4C16A 3N8XA 2P94L 2WG4B 3BPSE 3MQEA 1EQHA 2Q1JB 1PFXL 4X8VL 1IQIL 3H5CB 4ZHAB 1NQLB 2RNLA 3IJEB 4RRXA 5CKMA 2MGPA 3R05A 1U67A 3GISX 3N8VA 4JZDL 2VVUL 4CSYA 2Y38A 1DVAL 3U7UG 1RFNB 2BMGA 1AUTL 1PGEA 4ZXXL 2VWMK 2WFTA 1SZBA 4OTJA 2W2NE 2PHBB 2UWPB 5L2YL 5JW1A 2ADXA 3LIWB 1U8CB 1NFWB 4LORA 4M10A 3F6UL 2BQ7A 2WYGB 3LC5B 1CCVA 1IGZA 3LC3B 5IKRA 1NFUB 1KLIL 2P16L 2W2QE 1F7MA 5JB8E 4Y6DB 4BDXA 1PTHA 2OYUP 2XBWL 3CENL 5L30L 1NFYB 5JVYA 1G2MB 3LN0A 2BOHA 2W3KB 5JBCE 1MQ5L 2VJ3A 2K2SB 3TH3L 2P3FL 3LN1A 1L5GB 3HPTA 4Y7BB 3HO5A 3POYA 1HREA 3BT2A 5JBBE 1HAEA 3IITB 4O1ZA 1K36A 2XBVL 2W3IB 1HZ8A 5F1AA 3GCXE 1G1TA 4XL1A 2J94B 2EI7B 1IOXA 2PUQL 3N8WB 1N1IA 1IQJL 1W7XL 4Y79B 2BQ6A 2KB9A 4Y76B 1APQA 2W86A 4BTTA 1PXXA 3FCSB 1URKA 5KIRA 5K0HB 2BOXA 2F9BL 4BXSA 1ATEA 3HS6A 3ASIA 4E1GA 5JVZA 3V64C 4Y7AB 2M74A 3QH0A 4CUDA 3U73A 2D1JB 1F0RB 1IQKL 1ATAA 1UZQA 2TGFA 3QCWA 2RHPA 3C9AC 3TK5B 2WG3C 1WHFA 2WPHE 5CKQA 4YZUB 4MMXB 2P3UA 3OLTA 5JB9E 1XFEA 1IQHL 1IJQA 2UWLB 1IQFL 4LMFA 2KL7A 3KQEL 4BDWA 4RRZA 1FAXL 4COXA 1G2LB 1COUA 2BOKL 4MMYB 5EGMB 1YGCL 1X7AL 1C5MF 1NFXB 2J95B 4Z0KB 3ZYJB 1QFKL 2WPME 2XC4L 1ATBA 3CS7L 3NTGA 4D0FA 1EGFA 3M37L 1EQGA 1CVWL 2W26B 1LPGA 3LTFB 4A7IA 1BF9A 1FAKL 3ELAL 3SOBB 1DDXA 1HX2A 1LPZA 3SW2A 4BTUA 5COXA 1EPIA 4BTIA 4X8SL 3MDLA 2VH0B 2EI6B 3M36L 4O02B 1G1RA 2XBXL 3HO3A 1KLJL 1DIYA 1KLOA 2G00L 4G1MB 1KSNB 3N8WA 1EMOA 1V3XB 1WHEA 3F1SB 1LQDA 1CQEA 3KCGL 4PH9A 1XDTR 1LPKA 1YO8A 1JV2B 1G1SA 2P3TA 1IQGL 1DQBA 1IQLL 2J34B 2JKHL 3CA7A 1IQEL 1EPJA 3TK6B 2P93L 2J2UB 1EPGA 1EMNA 5KN5C 3FFGL 3K9XA 4Z6AL 1NPEB 1GK5A 2MHPA 3EGFA 1HJ7A 1NZIA 1IVOC 3KRKA 4RRWA 3N8YB 4YT7L 1Z6CA 2XC0L 4RS0A 2YGOA 5IKVA 3V65B 1J9CL 3RR3A 1FJSL 1UZPA 2DDUA 1IQML 5IKTA 1IOEL 1YUFA 2BOUA 3KL6B 2MGRA 1TPGA 1EBVA 3NJPC 2BO2A 3NTBA 3HS5A 1F7EA 2XBYL 2W2ME 1HAFA 4CUFA 3OLUA 2NPRA 2RA0L 2Y81B 1UZJA 2B7DL 2GD4A 1B9WA 2VH6B 1M1XB 1PRHA 4Z0LA 2VWOL 1KIGL 3HS7A 4NG9L 4JZEL 1EPHA 1WU1B 3P5BL 2J4IB 4ZXYL 4ZH8B 1Z6EL 2I9BA 3QMOA 4D90A 3HO4A 2Y5HL 2Y5FL 1HT8A 2WYJB 2WPKE 3TGFA 2BZ6L 2Y7ZB 1HRFA 3KK6A 4BXWA 1YUGA 2UWOB 1ADXA 2P3FN 1EAIC 1TOZA 1MQ6L 2XC5L 4FM5A 1I0UA 1CEJA 2Y5GL 2EI8B 4JZFL 4M11A 1XKAL 5IKQA 5FDQA 1UZKA 2VWLL 1ATDA 2FLGA 1L3YA 2WPIE 4AQTA 5L2ZL 1NT0A 2FD6A 1DX5I 1F0SB 2FZZL 4TGFA 3N8YA 1G1QA 2WFXB 4Y71B 5F19A 6COXA 4RUTA 2W2OE 2FLBL 3LTGD 2Y80B 2KV4A 1FSBA 1FFMA 3GCWE 2YGPA 3TZIA 5CKNA 2J38B 1FF7A 1W8BL 2P95L 1LMJA 1Q4GA 2VWNL 5E8DA 1A3PA 3KQCL 2W2PE 4X8UL 4XLWA 1CVUA 3Q3KB 2PR3B 2AYLA 2FLRL 3FBYA 1FE2A 1EZQB 1P9JA 5I46L 4RRYA 4OTYA 4X8TL 1OB1C 2VVCK 3LAQA 4ISHL 1N7DA 4NA9L 3KQDL 1IQNL 1K37A 4MMZB 2VVVL 3PGHA 1ZAQA 2Y7XB 4YT6L 3SOQA 1CX2A 4JYVL 3ZYIB 2P26A 4ISIL 1O5DL 4JYUL 5CISA 1YUKB 2Y82B 1MOXC 1JBUL 3KQBL 2I9AA 1IGXA 3BT1A 3CFWA 1TLEA 1JL9A 2WPJE 1XKBA 1IP0A 4D0EA 2CJIB 3TBDA 4XBMA 2OYEP 4CUEA 3DEMA 1HT5A 2K2TA 4NGAL 1CCFA 1HCGB 3ENSA 1APOA 2WPLE 5JBAE 3N8ZA 2H9EL 2P28B 2BQWA
chains in the Genus database with same CATH superfamily
4ZAEB 1P0SL 3ZYGA 3SOVA 3NT1A 3Q7DA 4C16A 3N8XA 2P94L 2WG4B 3BPSE 3MQEA 1EQHA 2Q1JB 1PFXL 4X8VL 1IQIL 3H5CB 4ZHAB 1NQLB 2RNLA 3IJEB 4RRXA 5CKMA 2MGPA 3R05A 1U67A 3GISX 3N8VA 4JZDL 2VVUL 4CSYA 2Y38A 1DVAL 3U7UG 1RFNB 2BMGA 1AUTL 1PGEA 4ZXXL 2VWMK 2WFTA 1SZBA 4OTJA 2W2NE 2PHBB 2UWPB 5L2YL 5JW1A 2ADXA 3LIWB 1U8CB 1NFWB 4LORA 4M10A 3F6UL 2BQ7A 2WYGB 2BT7A 3LC5B 1CCVA 1IGZA 3LC3B 5IKRA 1NFUB 1KLIL 2P16L 2W2QE 1F7MA 5JB8E 4Y6DB 4BDXA 1PTHA 2OYUP 2XBWL 3CENL 5L30L 1NFYB 5JVYA 1G2MB 3LN0A 2BOHA 2W3KB 5JBCE 1MQ5L 2VJ3A 2K2SB 3TH3L 2P3FL 3LN1A 1L5GB 3HPTA 4Y7BB 3HO5A 3POYA 1HREA 3BT2A 5JBBE 1HAEA 3IITB 4O1ZA 1K36A 2XBVL 2W3IB 1HZ8A 5F1AA 3GCXE 1G1TA 4XL1A 2J94B 2EI7B 1IOXA 2PUQL 3N8WB 1N1IA 1IQJL 1W7XL 4Y79B 2BQ6A 2KB9A 4Y76B 1APQA 2W86A 4BTTA 1PXXA 3FCSB 1URKA 5KIRA 5K0HB 2BOXA 2F9BL 4BXSA 4A94C 3HS6A 1ATEA 3ASIA 4E1GA 5JVZA 3V64C 4Y7AB 2M74A 3QH0A 4CUDA 3U73A 2D1JB 1F0RB 1IQKL 1ATAA 1UZQA 2TGFA 3QCWA 2RHPA 3C9AC 3TK5B 2WG3C 1WHFA 2WPHE 5CKQA 4YZUB 4MMXB 2P3UA 3OLTA 5JB9E 1XFEA 1IQHL 1IJQA 2UWLB 1IQFL 4LMFA 2KL7A 3KQEL 4BDWA 4RRZA 1FAXL 4COXA 1G2LB 1COUA 2BOKL 4MMYB 5EGMB 1YGCL 1X7AL 1C5MF 1NFXB 2J95B 4Z0KB 3ZYJB 1QFKL 2WPME 2XC4L 1ATBA 3CS7L 3NTGA 4D0FA 1EGFA 3M37L 1EQGA 1CVWL 2W26B 1LPGA 3LTFB 4A7IA 1BF9A 1FAKL 3ELAL 3SOBB 1DDXA 1HX2A 2H9EC 1LPZA 3SW2A 4BTUA 5COXA 1EPIA 4BTIA 4X8SL 3MDLA 2VH0B 2EI6B 3M36L 4O02B 1G1RA 2XBXL 3HO3A 1KLJL 1DIYA 1KLOA 2G00L 4G1MB 1KSNB 3N8WA 1EMOA 1V3XB 1WHEA 3F1SB 1LQDA 1CQEA 3KCGL 4PH9A 1XDTR 1LPKA 1YO8A 1JV2B 1G1SA 2P3TA 1IQGL 1DQBA 1IQLL 2J34B 2JKHL 3CA7A 1IQEL 1EPJA 3TK6B 2P93L 2J2UB 1EPGA 1EMNA 5KN5C 3FFGL 3K9XA 4Z6AL 1NPEB 1GK5A 2MHPA 3EGFA 1HJ7A 1NZIA 1IVOC 3KRKA 4RRWA 3N8YB 4YT7L 1Z6CA 2XC0L 4RS0A 2YGOA 5IKVA 3V65B 1J9CL 3RR3A 4GU4A 1FJSL 1UZPA 2DDUA 1IQML 1QIUA 5IKTA 1IOEL 1YUFA 2BOUA 3KL6B 2MGRA 1TPGA 1EBVA 3NJPC 2BO2A 3NTBA 3HS5A 1F7EA 2XBYL 2W2ME 1HAFA 3S6XA 4CUFA 3OLUA 2NPRA 2RA0L 2Y81B 1UZJA 2B7DL 2GD4A 1B9WA 2VH6B 1M1XB 1PRHA 4Z0LA 2VWOL 1KIGL 3HS7A 4NG9L 4JZEL 1EPHA 1WU1B 3P5BL 2J4IB 4ZXYL 4ZH8B 1Z6EL 2I9BA 3QMOA 4D90A 3HO4A 2Y5HL 2HORA 2Y5FL 1HT8A 2WYJB 2WPKE 3TGFA 2BZ6L 2Y7ZB 1HRFA 3KK6A 2BT8A 4BXWA 1YUGA 2UWOB 1ADXA 2P3FN 1EAIC 1TOZA 1MQ6L 2XC5L 1KKEA 4FM5A 1I0UA 1CEJA 2Y5GL 2EI8B 4JZFL 4M11A 1XKAL 5IKQA 5FDQA 1UZKA 2VWLL 1ATDA 2FLGA 1L3YA 2WPIE 4AQTA 5L2ZL 1NT0A 2FD6A 1DX5I 1F0SB 2FZZL 4TGFA 3N8YA 1G1QA 2WFXB 4Y71B 5F19A 6COXA 4RUTA 2VRSA 2W2OE 2FLBL 2WZPP 3LTGD 2Y80B 2KV4A 2HOXA 1FSBA 1FFMA 3GCWE 2YGPA 3TZIA 2JJLA 5CKNA 2J38B 1FF7A 1W8BL 2P95L 1LMJA 1Q4GA 2VWNL 5E8DA 1A3PA 3KQCL 2W2PE 4X8UL 4XLWA 1CVUA 3Q3KB 2PR3B 2AYLA 2FLRL 3FBYA 1FE2A 1EZQB 1P9JA 5I46L 4RRYA 4OTYA 4X8TL 1OB1C 1V1HA 2VVCK 3LAQA 4ISHL 1N7DA 4NA9L 3KQDL 1IQNL 1K37A 4MMZB 2VVVL 3PGHA 1ZAQA 2Y7XB 4YT6L 3SOQA 1CX2A 4JYVL 3ZYIB 2P26A 4ISIL 1O5DL 4JYUL 5CISA 1YUKB 2YGQA 2Y82B 1MOXC 1JBUL 3KQBL 2I9AA 1IGXA 3BT1A 3CFWA 2KNIA 1LMMA 1TLEA 1JL9A 2WPJE 1V1IA 1XKBA 1IP0A 1LK9A 4D0EA 2CJIB 3TBDA 4XBMA 2OYEP 4CUEA 3DEMA 2BSFA 1HT5A 2K2TA 4GU3A 4NGAL 1CCFA 1HCGB 3ENSA 1APOA 2WPLE 5JBAE 3N8ZA 2H9EL 2P28B 2BQWA
chains in the Genus database with same CATH topology
4ZAEB 1P0SL 3ZYGA 3SOVA 3NT1A 3Q7DA 4C16A 3N8XA 2P94L 2WG4B 3BPSE 3MQEA 1EQHA 2Q1JB 1PFXL 4X8VL 1IQIL 3H5CB 4ZHAB 1NQLB 2RNLA 3IJEB 4RRXA 5CKMA 2MGPA 3R05A 1U67A 3GISX 3N8VA 4JZDL 2VVUL 4CSYA 2Y38A 1DVAL 3U7UG 1RFNB 2BMGA 1AUTL 1PGEA 4ZXXL 2VWMK 2WFTA 1SZBA 4OTJA 2W2NE 2PHBB 2UWPB 5L2YL 5JW1A 2ADXA 3LIWB 1U8CB 1NFWB 4LORA 4M10A 3F6UL 2BQ7A 2WYGB 3LC5B 1CCVA 1IGZA 3LC3B 5IKRA 1NFUB 1KLIL 2P16L 2W2QE 1F7MA 5JB8E 4Y6DB 4BDXA 1PTHA 2OYUP 2XBWL 3CENL 5L30L 1NFYB 5JVYA 1G2MB 3LN0A 2BOHA 2W3KB 5JBCE 1MQ5L 2VJ3A 2K2SB 3TH3L 2P3FL 3LN1A 1L5GB 3HPTA 4Y7BB 3HO5A 3POYA 1HREA 3BT2A 5JBBE 1HAEA 3IITB 4O1ZA 1K36A 2XBVL 2W3IB 1HZ8A 5F1AA 3GCXE 1G1TA 4XL1A 2J94B 2EI7B 1IOXA 2PUQL 3N8WB 1N1IA 1IQJL 1W7XL 4Y79B 2BQ6A 2KB9A 4Y76B 1APQA 2W86A 4BTTA 1PXXA 3FCSB 1URKA 5KIRA 5K0HB 2BOXA 2F9BL 4BXSA 4A94C 3HS6A 1ATEA 3ASIA 4E1GA 5JVZA 3V64C 4Y7AB 2M74A 3QH0A 4CUDA 3U73A 2D1JB 1F0RB 1IQKL 1ATAA 1UZQA 2TGFA 3QCWA 2RHPA 3C9AC 3TK5B 2WG3C 1WHFA 2WPHE 5CKQA 4YZUB 4MMXB 2P3UA 3OLTA 5JB9E 1XFEA 1IQHL 1IJQA 2UWLB 1IQFL 4LMFA 2KL7A 3KQEL 4BDWA 4RRZA 1FAXL 4COXA 1G2LB 1COUA 2BOKL 4MMYB 5EGMB 1YGCL 1X7AL 1C5MF 1NFXB 2J95B 4Z0KB 3ZYJB 1QFKL 2WPME 2XC4L 1ATBA 3CS7L 3NTGA 4D0FA 1EGFA 3M37L 1EQGA 1CVWL 2W26B 1LPGA 3LTFB 4A7IA 1BF9A 1FAKL 3ELAL 3SOBB 1DDXA 1HX2A 2H9EC 1LPZA 3SW2A 4BTUA 5COXA 1EPIA 4BTIA 4X8SL 3MDLA 2VH0B 2EI6B 3M36L 4O02B 1G1RA 2XBXL 3HO3A 1KLJL 1DIYA 1KLOA 2G00L 4G1MB 1KSNB 3N8WA 1EMOA 1V3XB 1WHEA 3F1SB 1LQDA 1CQEA 3KCGL 4PH9A 1XDTR 1LPKA 1YO8A 1JV2B 1G1SA 2P3TA 1IQGL 1DQBA 1IQLL 2J34B 2JKHL 3CA7A 1IQEL 1EPJA 3TK6B 2P93L 2J2UB 1EPGA 1EMNA 5KN5C 3FFGL 3K9XA 4Z6AL 1NPEB 1GK5A 2MHPA 3EGFA 1HJ7A 1NZIA 1IVOC 3KRKA 4RRWA 3N8YB 4YT7L 1Z6CA 2XC0L 4RS0A 2YGOA 5IKVA 3V65B 1J9CL 3RR3A 1FJSL 1UZPA 2DDUA 1IQML 5IKTA 1IOEL 1YUFA 2BOUA 3KL6B 2MGRA 1TPGA 1EBVA 3NJPC 2BO2A 3NTBA 3HS5A 1F7EA 2XBYL 2W2ME 1HAFA 3S6XA 4CUFA 3OLUA 2NPRA 2RA0L 2Y81B 1UZJA 2B7DL 2GD4A 1B9WA 2VH6B 1M1XB 1PRHA 4Z0LA 2VWOL 1KIGL 3HS7A 4NG9L 4JZEL 1EPHA 1WU1B 3P5BL 2J4IB 4ZXYL 4ZH8B 1Z6EL 2I9BA 3QMOA 4D90A 3HO4A 2Y5HL 2Y5FL 1HT8A 2WYJB 2WPKE 3TGFA 2BZ6L 2Y7ZB 1HRFA 3KK6A 4BXWA 1YUGA 2UWOB 1ADXA 2P3FN 1EAIC 1TOZA 1MQ6L 2XC5L 4FM5A 1I0UA 1CEJA 2Y5GL 2EI8B 4JZFL 4M11A 1XKAL 5IKQA 5FDQA 1UZKA 2VWLL 1ATDA 2FLGA 1L3YA 2WPIE 4AQTA 5L2ZL 1NT0A 2FD6A 1DX5I 1F0SB 2FZZL 4TGFA 3N8YA 1G1QA 2WFXB 4Y71B 5F19A 6COXA 4RUTA 2W2OE 2FLBL 2WZPP 3LTGD 2Y80B 2KV4A 1FSBA 1FFMA 3GCWE 2YGPA 3TZIA 5CKNA 2J38B 1FF7A 1W8BL 2P95L 1LMJA 1Q4GA 2VWNL 5E8DA 1A3PA 3KQCL 2W2PE 4X8UL 4XLWA 1CVUA 3Q3KB 2PR3B 2AYLA 2FLRL 3FBYA 1FE2A 1EZQB 1P9JA 5I46L 4RRYA 4OTYA 4X8TL 1OB1C 2VVCK 3LAQA 4ISHL 1N7DA 4NA9L 3KQDL 1IQNL 1K37A 4MMZB 2VVVL 3PGHA 1ZAQA 2Y7XB 4YT6L 3SOQA 1CX2A 4JYVL 3ZYIB 2P26A 4ISIL 1O5DL 4JYUL 5CISA 1YUKB 2YGQA 2Y82B 1MOXC 1JBUL 3KQBL 2I9AA 1IGXA 3BT1A 3CFWA 2KNIA 1LMMA 1TLEA 1JL9A 2WPJE 1XKBA 1IP0A 4D0EA 2CJIB 3TBDA 4XBMA 2OYEP 4CUEA 3DEMA 1HT5A 2K2TA 4NGAL 1CCFA 1HCGB 3ENSA 1APOA 2WPLE 5JBAE 3N8ZA 2H9EL 2P28B 2BQWA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4ZAE B;  1P0S L;  3ZYG A;  3SOV A;  3NT1 A;  3Q7D A;  4C16 A;  3N8X A;  2P94 L;  2WG4 B;  3BPS E;  3MQE A;  1EQH A;  2Q1J B;  1PFX L;  4X8V L;  1IQI L;  3H5C B;  4ZHA B;  1NQL B;  2RNL A;  3IJE B;  4RRX A;  5CKM A;  2MGP A;  3R05 A;  1U67 A;  3GIS X;  3N8V A;  4JZD L;  2VVU L;  4CSY A;  2Y38 A;  1DVA L;  3U7U G;  1RFN B;  2BMG A;  1AUT L;  1PGE A;  4ZXX L;  2VWM K;  2WFT A;  1SZB A;  4OTJ A;  2W2N E;  2PHB B;  2UWP B;  5L2Y L;  5JW1 A;  2ADX A;  3LIW B;  1U8C B;  1NFW B;  4LOR A;  4M10 A;  3F6U L;  2BQ7 A;  2WYG B;  3LC5 B;  1CCV A;  1IGZ A;  3LC3 B;  5IKR A;  1NFU B;  1KLI L;  2P16 L;  2W2Q E;  1F7M A;  5JB8 E;  4Y6D B;  4BDX A;  1PTH A;  2OYU P;  2XBW L;  3CEN L;  5L30 L;  1NFY B;  5JVY A;  1G2M B;  3LN0 A;  2BOH A;  2W3K B;  5JBC E;  1MQ5 L;  2VJ3 A;  2K2S B;  3TH3 L;  2P3F L;  3LN1 A;  1L5G B;  3HPT A;  4Y7B B;  3HO5 A;  3POY A;  1HRE A;  3BT2 A;  5JBB E;  1HAE A;  3IIT B;  4O1Z A;  1K36 A;  2XBV L;  2W3I B;  1HZ8 A;  5F1A A;  3GCX E;  1G1T A;  4XL1 A;  2J94 B;  2EI7 B;  1IOX A;  2PUQ L;  3N8W B;  1N1I A;  1IQJ L;  1W7X L;  4Y79 B;  2BQ6 A;  2KB9 A;  4Y76 B;  1APQ A;  2W86 A;  4BTT A;  1PXX A;  3FCS B;  1URK A;  5KIR A;  5K0H B;  2BOX A;  2F9B L;  4BXS A;  1ATE A;  3HS6 A;  3ASI A;  4E1G A;  5JVZ A;  3V64 C;  4Y7A B;  2M74 A;  3QH0 A;  4CUD A;  3U73 A;  2D1J B;  1F0R B;  1IQK L;  1ATA A;  1UZQ A;  2TGF A;  3QCW A;  2RHP A;  3C9A C;  3TK5 B;  2WG3 C;  1WHF A;  2WPH E;  5CKQ A;  4YZU B;  4MMX B;  2P3U A;  3OLT A;  5JB9 E;  1XFE A;  1IQH L;  1IJQ A;  2UWL B;  1IQF L;  4LMF A;  2KL7 A;  3KQE L;  4BDW A;  4RRZ A;  1FAX L;  4COX A;  1G2L B;  1COU A;  2BOK L;  4MMY B;  5EGM B;  1YGC L;  1X7A L;  1C5M F;  1NFX B;  2J95 B;  4Z0K B;  3ZYJ B;  1QFK L;  2WPM E;  2XC4 L;  1ATB A;  3CS7 L;  3NTG A;  4D0F A;  1EGF A;  3M37 L;  1EQG A;  1CVW L;  2W26 B;  1LPG A;  3LTF B;  4A7I A;  1BF9 A;  1FAK L;  3ELA L;  3SOB B;  1DDX A;  1HX2 A;  1LPZ A;  3SW2 A;  4BTU A;  5COX A;  1EPI A;  4BTI A;  4X8S L;  3MDL A;  2VH0 B;  2EI6 B;  3M36 L;  4O02 B;  1G1R A;  2XBX L;  3HO3 A;  1KLJ L;  1DIY A;  1KLO A;  2G00 L;  4G1M B;  1KSN B;  3N8W A;  1EMO A;  1V3X B;  1WHE A;  3F1S B;  1LQD A;  1CQE A;  3KCG L;  4PH9 A;  1XDT R;  1LPK A;  1YO8 A;  1JV2 B;  1G1S A;  2P3T A;  1IQG L;  1DQB A;  1IQL L;  2J34 B;  2JKH L;  3CA7 A;  1IQE L;  1EPJ A;  3TK6 B;  2P93 L;  2J2U B;  1EPG A;  1EMN A;  5KN5 C;  3FFG L;  3K9X A;  4Z6A L;  1NPE B;  1GK5 A;  2MHP A;  3EGF A;  1HJ7 A;  1NZI A;  1IVO C;  3KRK A;  4RRW A;  3N8Y B;  4YT7 L;  1Z6C A;  2XC0 L;  4RS0 A;  2YGO A;  5IKV A;  3V65 B;  1J9C L;  3RR3 A;  1FJS L;  1UZP A;  2DDU A;  1IQM L;  5IKT A;  1IOE L;  1YUF A;  2BOU A;  3KL6 B;  2MGR A;  1TPG A;  1EBV A;  3NJP C;  2BO2 A;  3NTB A;  3HS5 A;  1F7E A;  2XBY L;  2W2M E;  1HAF A;  4CUF A;  3OLU A;  2NPR A;  2RA0 L;  2Y81 B;  1UZJ A;  2B7D L;  2GD4 A;  1B9W A;  2VH6 B;  1M1X B;  1PRH A;  4Z0L A;  2VWO L;  1KIG L;  3HS7 A;  4NG9 L;  4JZE L;  1EPH A;  1WU1 B;  3P5B L;  2J4I B;  4ZXY L;  4ZH8 B;  1Z6E L;  2I9B A;  3QMO A;  4D90 A;  3HO4 A;  2Y5H L;  2Y5F L;  1HT8 A;  2WYJ B;  2WPK E;  3TGF A;  2BZ6 L;  2Y7Z B;  1HRF A;  3KK6 A;  4BXW A;  1YUG A;  2UWO B;  1ADX A;  2P3F N;  1EAI C;  1TOZ A;  1MQ6 L;  2XC5 L;  4FM5 A;  1I0U A;  1CEJ A;  2Y5G L;  2EI8 B;  4JZF L;  4M11 A;  1XKA L;  5IKQ A;  5FDQ A;  1UZK A;  2VWL L;  1ATD A;  2FLG A;  1L3Y A;  2WPI E;  4AQT A;  5L2Z L;  1NT0 A;  2FD6 A;  1DX5 I;  1F0S B;  2FZZ L;  4TGF A;  3N8Y A;  1G1Q A;  2WFX B;  4Y71 B;  5F19 A;  6COX A;  4RUT A;  2W2O E;  2FLB L;  3LTG D;  2Y80 B;  2KV4 A;  1FSB A;  1FFM A;  3GCW E;  2YGP A;  3TZI A;  5CKN A;  2J38 B;  1FF7 A;  1W8B L;  2P95 L;  1LMJ A;  1Q4G A;  2VWN L;  5E8D A;  1A3P A;  3KQC L;  2W2P E;  4X8U L;  4XLW A;  1CVU A;  3Q3K B;  2PR3 B;  2AYL A;  2FLR L;  3FBY A;  1FE2 A;  1EZQ B;  1P9J A;  5I46 L;  4RRY A;  4OTY A;  4X8T L;  1OB1 C;  2VVC K;  3LAQ A;  4ISH L;  1N7D A;  4NA9 L;  3KQD L;  1IQN L;  1K37 A;  4MMZ B;  2VVV L;  3PGH A;  1ZAQ A;  2Y7X B;  4YT6 L;  3SOQ A;  1CX2 A;  4JYV L;  3ZYI B;  2P26 A;  4ISI L;  1O5D L;  4JYU L;  5CIS A;  1YUK B;  2Y82 B;  1MOX C;  1JBU L;  3KQB L;  2I9A A;  1IGX A;  3BT1 A;  3CFW A;  1TLE A;  1JL9 A;  2WPJ E;  1XKB A;  1IP0 A;  4D0E A;  2CJI B;  3TBD A;  4XBM A;  2OYE P;  4CUE A;  3DEM A;  1HT5 A;  2K2T A;  4NGA L;  1CCF A;  1HCG B;  3ENS A;  1APO A;  2WPL E;  5JBA E;  3N8Z A;  2H9E L;  2P28 B;  2BQW A; 
#chains in the Genus database with same CATH topology
 4ZAE B;  1P0S L;  3ZYG A;  3SOV A;  3NT1 A;  3Q7D A;  4C16 A;  3N8X A;  2P94 L;  2WG4 B;  3BPS E;  3MQE A;  1EQH A;  2Q1J B;  1PFX L;  4X8V L;  1IQI L;  3H5C B;  4ZHA B;  1NQL B;  2RNL A;  3IJE B;  4RRX A;  5CKM A;  2MGP A;  3R05 A;  1U67 A;  3GIS X;  3N8V A;  4JZD L;  2VVU L;  4CSY A;  2Y38 A;  1DVA L;  3U7U G;  1RFN B;  2BMG A;  1AUT L;  1PGE A;  4ZXX L;  2VWM K;  2WFT A;  1SZB A;  4OTJ A;  2W2N E;  2PHB B;  2UWP B;  5L2Y L;  5JW1 A;  2ADX A;  3LIW B;  1U8C B;  1NFW B;  4LOR A;  4M10 A;  3F6U L;  2BQ7 A;  2WYG B;  2BT7 A;  3LC5 B;  1CCV A;  1IGZ A;  3LC3 B;  5IKR A;  1NFU B;  1KLI L;  2P16 L;  2W2Q E;  1F7M A;  5JB8 E;  4Y6D B;  4BDX A;  1PTH A;  2OYU P;  2XBW L;  3CEN L;  5L30 L;  1NFY B;  5JVY A;  1G2M B;  3LN0 A;  2BOH A;  2W3K B;  5JBC E;  1MQ5 L;  2VJ3 A;  2K2S B;  3TH3 L;  2P3F L;  3LN1 A;  1L5G B;  3HPT A;  4Y7B B;  3HO5 A;  3POY A;  1HRE A;  3BT2 A;  5JBB E;  1HAE A;  3IIT B;  4O1Z A;  1K36 A;  2XBV L;  2W3I B;  1HZ8 A;  5F1A A;  3GCX E;  1G1T A;  4XL1 A;  2J94 B;  2EI7 B;  1IOX A;  2PUQ L;  3N8W B;  1N1I A;  1IQJ L;  1W7X L;  4Y79 B;  2BQ6 A;  2KB9 A;  4Y76 B;  1APQ A;  2W86 A;  4BTT A;  1PXX A;  3FCS B;  1URK A;  5KIR A;  5K0H B;  2BOX A;  2F9B L;  4BXS A;  4A94 C;  3HS6 A;  1ATE A;  3ASI A;  4E1G A;  5JVZ A;  3V64 C;  4Y7A B;  2M74 A;  3QH0 A;  4CUD A;  3U73 A;  2D1J B;  1F0R B;  1IQK L;  1ATA A;  1UZQ A;  2TGF A;  3QCW A;  2RHP A;  3C9A C;  3TK5 B;  2WG3 C;  1WHF A;  2WPH E;  5CKQ A;  4YZU B;  4MMX B;  2P3U A;  3OLT A;  5JB9 E;  1XFE A;  1IQH L;  1IJQ A;  2UWL B;  1IQF L;  4LMF A;  2KL7 A;  3KQE L;  4BDW A;  4RRZ A;  1FAX L;  4COX A;  1G2L B;  1COU A;  2BOK L;  4MMY B;  5EGM B;  1YGC L;  1X7A L;  1C5M F;  1NFX B;  2J95 B;  4Z0K B;  3ZYJ B;  1QFK L;  2WPM E;  2XC4 L;  1ATB A;  3CS7 L;  3NTG A;  4D0F A;  1EGF A;  3M37 L;  1EQG A;  1CVW L;  2W26 B;  1LPG A;  3LTF B;  4A7I A;  1BF9 A;  1FAK L;  3ELA L;  3SOB B;  1DDX A;  1HX2 A;  2H9E C;  1LPZ A;  3SW2 A;  4BTU A;  5COX A;  1EPI A;  4BTI A;  4X8S L;  3MDL A;  2VH0 B;  2EI6 B;  3M36 L;  4O02 B;  1G1R A;  2XBX L;  3HO3 A;  1KLJ L;  1DIY A;  1KLO A;  2G00 L;  4G1M B;  1KSN B;  3N8W A;  1EMO A;  1V3X B;  1WHE A;  3F1S B;  1LQD A;  1CQE A;  3KCG L;  4PH9 A;  1XDT R;  1LPK A;  1YO8 A;  1JV2 B;  1G1S A;  2P3T A;  1IQG L;  1DQB A;  1IQL L;  2J34 B;  2JKH L;  3CA7 A;  1IQE L;  1EPJ A;  3TK6 B;  2P93 L;  2J2U B;  1EPG A;  1EMN A;  5KN5 C;  3FFG L;  3K9X A;  4Z6A L;  1NPE B;  1GK5 A;  2MHP A;  3EGF A;  1HJ7 A;  1NZI A;  1IVO C;  3KRK A;  4RRW A;  3N8Y B;  4YT7 L;  1Z6C A;  2XC0 L;  4RS0 A;  2YGO A;  5IKV A;  3V65 B;  1J9C L;  3RR3 A;  4GU4 A;  1FJS L;  1UZP A;  2DDU A;  1IQM L;  1QIU A;  5IKT A;  1IOE L;  1YUF A;  2BOU A;  3KL6 B;  2MGR A;  1TPG A;  1EBV A;  3NJP C;  2BO2 A;  3NTB A;  3HS5 A;  1F7E A;  2XBY L;  2W2M E;  1HAF A;  3S6X A;  4CUF A;  3OLU A;  2NPR A;  2RA0 L;  2Y81 B;  1UZJ A;  2B7D L;  2GD4 A;  1B9W A;  2VH6 B;  1M1X B;  1PRH A;  4Z0L A;  2VWO L;  1KIG L;  3HS7 A;  4NG9 L;  4JZE L;  1EPH A;  1WU1 B;  3P5B L;  2J4I B;  4ZXY L;  4ZH8 B;  1Z6E L;  2I9B A;  3QMO A;  4D90 A;  3HO4 A;  2Y5H L;  2HOR A;  2Y5F L;  1HT8 A;  2WYJ B;  2WPK E;  3TGF A;  2BZ6 L;  2Y7Z B;  1HRF A;  3KK6 A;  2BT8 A;  4BXW A;  1YUG A;  2UWO B;  1ADX A;  2P3F N;  1EAI C;  1TOZ A;  1MQ6 L;  2XC5 L;  1KKE A;  4FM5 A;  1I0U A;  1CEJ A;  2Y5G L;  2EI8 B;  4JZF L;  4M11 A;  1XKA L;  5IKQ A;  5FDQ A;  1UZK A;  2VWL L;  1ATD A;  2FLG A;  1L3Y A;  2WPI E;  4AQT A;  5L2Z L;  1NT0 A;  2FD6 A;  1DX5 I;  1F0S B;  2FZZ L;  4TGF A;  3N8Y A;  1G1Q A;  2WFX B;  4Y71 B;  5F19 A;  6COX A;  4RUT A;  2VRS A;  2W2O E;  2FLB L;  2WZP P;  3LTG D;  2Y80 B;  2KV4 A;  2HOX A;  1FSB A;  1FFM A;  3GCW E;  2YGP A;  3TZI A;  2JJL A;  5CKN A;  2J38 B;  1FF7 A;  1W8B L;  2P95 L;  1LMJ A;  1Q4G A;  2VWN L;  5E8D A;  1A3P A;  3KQC L;  2W2P E;  4X8U L;  4XLW A;  1CVU A;  3Q3K B;  2PR3 B;  2AYL A;  2FLR L;  3FBY A;  1FE2 A;  1EZQ B;  1P9J A;  5I46 L;  4RRY A;  4OTY A;  4X8T L;  1OB1 C;  1V1H A;  2VVC K;  3LAQ A;  4ISH L;  1N7D A;  4NA9 L;  3KQD L;  1IQN L;  1K37 A;  4MMZ B;  2VVV L;  3PGH A;  1ZAQ A;  2Y7X B;  4YT6 L;  3SOQ A;  1CX2 A;  4JYV L;  3ZYI B;  2P26 A;  4ISI L;  1O5D L;  4JYU L;  5CIS A;  1YUK B;  2YGQ A;  2Y82 B;  1MOX C;  1JBU L;  3KQB L;  2I9A A;  1IGX A;  3BT1 A;  3CFW A;  2KNI A;  1LMM A;  1TLE A;  1JL9 A;  2WPJ E;  1V1I A;  1XKB A;  1IP0 A;  1LK9 A;  4D0E A;  2CJI B;  3TBD A;  4XBM A;  2OYE P;  4CUE A;  3DEM A;  2BSF A;  1HT5 A;  2K2T A;  4GU3 A;  4NGA L;  1CCF A;  1HCG B;  3ENS A;  1APO A;  2WPL E;  5JBA E;  3N8Z A;  2H9E L;  2P28 B;  2BQW A; 
#chains in the Genus database with same CATH homology
 4ZAE B;  1P0S L;  3ZYG A;  3SOV A;  3NT1 A;  3Q7D A;  4C16 A;  3N8X A;  2P94 L;  2WG4 B;  3BPS E;  3MQE A;  1EQH A;  2Q1J B;  1PFX L;  4X8V L;  1IQI L;  3H5C B;  4ZHA B;  1NQL B;  2RNL A;  3IJE B;  4RRX A;  5CKM A;  2MGP A;  3R05 A;  1U67 A;  3GIS X;  3N8V A;  4JZD L;  2VVU L;  4CSY A;  2Y38 A;  1DVA L;  3U7U G;  1RFN B;  2BMG A;  1AUT L;  1PGE A;  4ZXX L;  2VWM K;  2WFT A;  1SZB A;  4OTJ A;  2W2N E;  2PHB B;  2UWP B;  5L2Y L;  5JW1 A;  2ADX A;  3LIW B;  1U8C B;  1NFW B;  4LOR A;  4M10 A;  3F6U L;  2BQ7 A;  2WYG B;  3LC5 B;  1CCV A;  1IGZ A;  3LC3 B;  5IKR A;  1NFU B;  1KLI L;  2P16 L;  2W2Q E;  1F7M A;  5JB8 E;  4Y6D B;  4BDX A;  1PTH A;  2OYU P;  2XBW L;  3CEN L;  5L30 L;  1NFY B;  5JVY A;  1G2M B;  3LN0 A;  2BOH A;  2W3K B;  5JBC E;  1MQ5 L;  2VJ3 A;  2K2S B;  3TH3 L;  2P3F L;  3LN1 A;  1L5G B;  3HPT A;  4Y7B B;  3HO5 A;  3POY A;  1HRE A;  3BT2 A;  5JBB E;  1HAE A;  3IIT B;  4O1Z A;  1K36 A;  2XBV L;  2W3I B;  1HZ8 A;  5F1A A;  3GCX E;  1G1T A;  4XL1 A;  2J94 B;  2EI7 B;  1IOX A;  2PUQ L;  3N8W B;  1N1I A;  1IQJ L;  1W7X L;  4Y79 B;  2BQ6 A;  2KB9 A;  4Y76 B;  1APQ A;  2W86 A;  4BTT A;  1PXX A;  3FCS B;  1URK A;  5KIR A;  5K0H B;  2BOX A;  2F9B L;  4BXS A;  4A94 C;  3HS6 A;  1ATE A;  3ASI A;  4E1G A;  5JVZ A;  3V64 C;  4Y7A B;  2M74 A;  3QH0 A;  4CUD A;  3U73 A;  2D1J B;  1F0R B;  1IQK L;  1ATA A;  1UZQ A;  2TGF A;  3QCW A;  2RHP A;  3C9A C;  3TK5 B;  2WG3 C;  1WHF A;  2WPH E;  5CKQ A;  4YZU B;  4MMX B;  2P3U A;  3OLT A;  5JB9 E;  1XFE A;  1IQH L;  1IJQ A;  2UWL B;  1IQF L;  4LMF A;  2KL7 A;  3KQE L;  4BDW A;  4RRZ A;  1FAX L;  4COX A;  1G2L B;  1COU A;  2BOK L;  4MMY B;  5EGM B;  1YGC L;  1X7A L;  1C5M F;  1NFX B;  2J95 B;  4Z0K B;  3ZYJ B;  1QFK L;  2WPM E;  2XC4 L;  1ATB A;  3CS7 L;  3NTG A;  4D0F A;  1EGF A;  3M37 L;  1EQG A;  1CVW L;  2W26 B;  1LPG A;  3LTF B;  4A7I A;  1BF9 A;  1FAK L;  3ELA L;  3SOB B;  1DDX A;  1HX2 A;  2H9E C;  1LPZ A;  3SW2 A;  4BTU A;  5COX A;  1EPI A;  4BTI A;  4X8S L;  3MDL A;  2VH0 B;  2EI6 B;  3M36 L;  4O02 B;  1G1R A;  2XBX L;  3HO3 A;  1KLJ L;  1DIY A;  1KLO A;  2G00 L;  4G1M B;  1KSN B;  3N8W A;  1EMO A;  1V3X B;  1WHE A;  3F1S B;  1LQD A;  1CQE A;  3KCG L;  4PH9 A;  1XDT R;  1LPK A;  1YO8 A;  1JV2 B;  1G1S A;  2P3T A;  1IQG L;  1DQB A;  1IQL L;  2J34 B;  2JKH L;  3CA7 A;  1IQE L;  1EPJ A;  3TK6 B;  2P93 L;  2J2U B;  1EPG A;  1EMN A;  5KN5 C;  3FFG L;  3K9X A;  4Z6A L;  1NPE B;  1GK5 A;  2MHP A;  3EGF A;  1HJ7 A;  1NZI A;  1IVO C;  3KRK A;  4RRW A;  3N8Y B;  4YT7 L;  1Z6C A;  2XC0 L;  4RS0 A;  2YGO A;  5IKV A;  3V65 B;  1J9C L;  3RR3 A;  1FJS L;  1UZP A;  2DDU A;  1IQM L;  5IKT A;  1IOE L;  1YUF A;  2BOU A;  3KL6 B;  2MGR A;  1TPG A;  1EBV A;  3NJP C;  2BO2 A;  3NTB A;  3HS5 A;  1F7E A;  2XBY L;  2W2M E;  1HAF A;  3S6X A;  4CUF A;  3OLU A;  2NPR A;  2RA0 L;  2Y81 B;  1UZJ A;  2B7D L;  2GD4 A;  1B9W A;  2VH6 B;  1M1X B;  1PRH A;  4Z0L A;  2VWO L;  1KIG L;  3HS7 A;  4NG9 L;  4JZE L;  1EPH A;  1WU1 B;  3P5B L;  2J4I B;  4ZXY L;  4ZH8 B;  1Z6E L;  2I9B A;  3QMO A;  4D90 A;  3HO4 A;  2Y5H L;  2Y5F L;  1HT8 A;  2WYJ B;  2WPK E;  3TGF A;  2BZ6 L;  2Y7Z B;  1HRF A;  3KK6 A;  4BXW A;  1YUG A;  2UWO B;  1ADX A;  2P3F N;  1EAI C;  1TOZ A;  1MQ6 L;  2XC5 L;  4FM5 A;  1I0U A;  1CEJ A;  2Y5G L;  2EI8 B;  4JZF L;  4M11 A;  1XKA L;  5IKQ A;  5FDQ A;  1UZK A;  2VWL L;  1ATD A;  2FLG A;  1L3Y A;  2WPI E;  4AQT A;  5L2Z L;  1NT0 A;  2FD6 A;  1DX5 I;  1F0S B;  2FZZ L;  4TGF A;  3N8Y A;  1G1Q A;  2WFX B;  4Y71 B;  5F19 A;  6COX A;  4RUT A;  2W2O E;  2FLB L;  2WZP P;  3LTG D;  2Y80 B;  2KV4 A;  1FSB A;  1FFM A;  3GCW E;  2YGP A;  3TZI A;  5CKN A;  2J38 B;  1FF7 A;  1W8B L;  2P95 L;  1LMJ A;  1Q4G A;  2VWN L;  5E8D A;  1A3P A;  3KQC L;  2W2P E;  4X8U L;  4XLW A;  1CVU A;  3Q3K B;  2PR3 B;  2AYL A;  2FLR L;  3FBY A;  1FE2 A;  1EZQ B;  1P9J A;  5I46 L;  4RRY A;  4OTY A;  4X8T L;  1OB1 C;  2VVC K;  3LAQ A;  4ISH L;  1N7D A;  4NA9 L;  3KQD L;  1IQN L;  1K37 A;  4MMZ B;  2VVV L;  3PGH A;  1ZAQ A;  2Y7X B;  4YT6 L;  3SOQ A;  1CX2 A;  4JYV L;  3ZYI B;  2P26 A;  4ISI L;  1O5D L;  4JYU L;  5CIS A;  1YUK B;  2YGQ A;  2Y82 B;  1MOX C;  1JBU L;  3KQB L;  2I9A A;  1IGX A;  3BT1 A;  3CFW A;  2KNI A;  1LMM A;  1TLE A;  1JL9 A;  2WPJ E;  1XKB A;  1IP0 A;  4D0E A;  2CJI B;  3TBD A;  4XBM A;  2OYE P;  4CUE A;  3DEM A;  1HT5 A;  2K2T A;  4NGA L;  1CCF A;  1HCG B;  3ENS A;  1APO A;  2WPL E;  5JBA E;  3N8Z A;  2H9E L;  2P28 B;  2BQW A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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