3U7UG

Crystal structure of extracellular region of human epidermal growth factor receptor 4 in complex with neuregulin-1 beta
Total Genus 8
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
8
sequence length
52
structure length
50
Chain Sequence
SHLVKCAEKEKTFCVNGGECFMVKDLPSRYLCKCPNEFTGDRCQNYVMAS
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title A single ligand is sufficient to activate EGFR dimers.
pubmed doi rcsb
molecule tags Transferase/transferase regulator
source organism Homo sapiens
molecule keywords Receptor tyrosine-protein kinase erbB-4
total genus 8
structure length 50
sequence length 52
chains with identical sequence H, I, J, K, L
ec nomenclature
pdb deposition date 2011-10-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
G PF00008 EGF EGF-like domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.25.10 Mainly Beta Ribbon Laminin Laminin 3u7uG00
2J95B 1C5MF 4BTUA 3KQBL 1F0SB 4OTYA 1IQKL 3BT1A 2WFTA 1L5GB 2W2PE 1YO8A 3CS7L 3KQCL 5IKRA 2I9BA 4TGFA 3EGFA 2P95L 1IQEL 1FAKL 1DVAL 2DDUA 4A7IA 1G2LB 1IP0A 4Y6DB 2BQ6A 1CEJA 2FZZL 2J38B 2VVUL 2W3KB 1V3XB 1F0RB 4ISIL 3LC3B 2FD6A 1FE2A 4BDWA 1W7XL 1HAFA 5L30L 2XBXL 3ELAL 4PH9A 1L3YA 1IQJL 1ADXA 3FBYA 5JW1A 1XKBA 2B7DL 1HT5A 3P5BL 2CJIB 1COUA 4YT6L 2FLBL 2RA0L 2BOXA 2WYJB 2Y7ZB 5L2YL 2WPME 3N8WA 1IJQA 1W8BL 4MMZB 1GK5A 4JZDL 2W26B 5JBBE 2W2ME 4Y7BB 3TK6B 1IOXA 1DQBA 3LAQA 2VH6B 1CCVA 4C16A 1O5DL 2RHPA 2UWPB 3N8VA 3FFGL 2BMGA 3HS6A 2P3UA 3DEMA 4RUTA 1IQFL 2KL7A 3LC5B 4NG9L 2VWOL 1OB1C 3ZYJB 2W3IB 1APQA 3F6UL 5JBAE 2BQWA 2KB9A 2XC0L 4G1MB 4ZXYL 1F7MA 3NTBA 4RRWA 3NT1A 1YUKB 1IOEL 3GCWE 3TK5B 1FF7A 2G00L 4RRZA 1Q4GA 4JYVL 1ATDA 1DDXA 1M1XB 1QFKL 4JYUL 4COXA 3HS7A 5JVYA 4X8TL 4X8SL 2EI6B 4Z0KB 4JZEL 2WFXB 1RFNB 4MMYB 3HPTA 2P16L 2Y7XB 4ZH8B 2OYEP 1UZPA 4Z0LA 1ATEA 2AYLA 3RR3A 1JBUL 2MHPA 1TPGA 1NT0A 3GISX 1IQLL 1G1QA 2BZ6L 2VWMK 3M37L 5F19A 4ISHL 2P28B 1EQHA 3C9AC 1IQIL 1NFUB 3BPSE 3FCSB 4XL1A 1P9JA 5IKVA 5IKQA 1Z6EL 3QMOA 2XBWL 3LN1A 1PGEA 5I46L 3TGFA 1PFXL 1APOA 1A3PA 1CCFA 2VWNL 3MQEA 1U8CB 1IGXA 1X7AL 4YZUB 2Q1JB 6COXA 1ATAA 2BQ7A 1WHEA 2VVCK 1UZQA 1IQHL 1KLOA 1XDTR 3SW2A 3CENL 2WPIE 1URKA 5JBCE 3HS5A 2VH0B 2VWLL 5EGMB 1IQNL 3KRKA 2W2QE 4LMFA 4Y71B 3N8ZA 1HX2A 1HRFA 1K37A 2P93L 3ZYIB 1CQEA 2GD4A 4CUEA 1EPGA 1FSBA 2ADXA 1IQGL 2BOUA 4MMXB 2FLRL 4LORA 2P26A 4RRYA 3CA7A 2XBYL 1IVOC 3Q7DA 3SOQA 3KCGL 1LMJA 2KV4A 2J94B 1WHFA 4ZAEB 2EI8B 4O1ZA 1LPKA 2WPKE 1HT8A 2F9BL 1TOZA 2JKHL 1MQ6L 2TGFA 1NQLB 2NPRA 1G1RA 3KL6B 1EBVA 4CUFA 1XFEA 2K2TA 3N8YA 1AUTL 3N8WB 3H5CB 4RS0A 5F1AA 1EAIC 1J9CL 3MDLA 3SOVA 2WPJE 1G1TA 2VVVL 4M10A 4CUDA 5E8DA 1UZJA 1Z6CA 2P94L 4D0FA 3LTGD 2OYUP 1HREA 5KIRA 3ENSA 1EQGA 4D0EA 4BDXA 4E1GA 2BOHA 3IITB 4Y76B 2WPHE 3TH3L 2J4IB 1KLJL 1I0UA 2XC5L 1G1SA 2MGRA 1U67A 1LPZA 1EGFA 4X8VL 4D90A 5K0HB 3N8YB 5CISA 3SOBB 3U73A 3V65B 1MQ5L 1SZBA 3Q3KB 2WG3C 1LQDA 3KQDL 5JB8E 1NZIA 1IGZA 5CKQA 1JL9A 3TBDA 1NFXB 2UWOB 3ZYGA 1EPIA 2Y38A 3GCXE 1CVWL 3K9XA 5JB9E 2PHBB 4Y7AB 2J2UB 1LPGA 2D1JB 5JVZA 1EPJA 4AQTA 3POYA 3ASIA 2PR3B 2BOKL 2M74A 1FAXL 3NJPC 4M11A 4RRXA 3HO4A 1HJ7A 2P3FL 1P0SL 1EZQB 1N1IA 1K36A 1B9WA 1N7DA 4BTIA 4X8UL 4CSYA 5CKNA 2RNLA 4NA9L 4Y79B 1F7EA 1WU1B 2XBVL 1PRHA 1ZAQA 4Z6AL 5FDQA 3HO3A 2MGPA 3QCWA 3N8XA 3F1SB 2Y5GL 1XKAL 5KN5C 3LN0A 2P3FN 1EMNA 3OLUA 2FLGA 3BT2A 1FFMA 1JV2B 2H9EL 2P3TA 5COXA 3QH0A 2Y81B 1KIGL 2J34B 1PXXA 1YGCL 4JZFL 1YUGA 4XLWA 2PUQL 4BXWA 1ATBA 4BTTA 2I9AA 1NFYB 4ZXXL 3IJEB 3CFWA 1UZKA 1TLEA 2Y5FL 2YGOA 2YGPA 2Y80B 1KSNB 2VJ3A 3R05A 2W2OE 3LTFB 4O02B 1NFWB 5CKMA 1FJSL 2WG4B 4FM5A 4BXSA 1PTHA 1KLIL 1DX5I 3U7UG 1HCGB 1HZ8A 4OTJA 4NGAL 3NTGA 2W2NE 1BF9A 3V64C 1YUFA 1G2MB 5L2ZL 3M36L 2Y82B 2WYGB 5IKTA 2XC4L 1HAEA 3TZIA 1MOXC 1CVUA 2K2SB 2EI7B 1EPHA 2WPLE 2W86A 1NPEB 4XBMA 2UWLB 3PGHA 4YT7L 2BO2A 1IQML 1DIYA 3KQEL 3KK6A 1CX2A 4ZHAB 1EMOA 3OLTA 2Y5HL 3HO5A 3LIWB
chains in the Genus database with same CATH superfamily
2J95B 1C5MF 4BTUA 3KQBL 1F0SB 4OTYA 1IQKL 3BT1A 2WFTA 1L5GB 2W2PE 1YO8A 3CS7L 3KQCL 5IKRA 2I9BA 4TGFA 3EGFA 4GU4A 2P95L 4GU3A 1IQEL 1FAKL 1DVAL 2DDUA 4A7IA 1G2LB 1IP0A 4Y6DB 2BQ6A 1CEJA 2FZZL 2J38B 2VVUL 2W3KB 1V3XB 1F0RB 4ISIL 3LC3B 2FD6A 2BSFA 1FE2A 4BDWA 1W7XL 1HAFA 5L30L 2XBXL 3ELAL 4PH9A 1L3YA 1IQJL 1ADXA 3FBYA 5JW1A 1XKBA 2B7DL 1HT5A 3P5BL 2CJIB 1COUA 4YT6L 2FLBL 2RA0L 2BOXA 2WYJB 2Y7ZB 2KNIA 5L2YL 2WPME 3N8WA 1IJQA 1W8BL 4MMZB 1GK5A 4JZDL 2W26B 5JBBE 2W2ME 4Y7BB 3TK6B 1IOXA 1DQBA 3LAQA 2VH6B 1CCVA 4C16A 1O5DL 2RHPA 2UWPB 3N8VA 3FFGL 2BMGA 3HS6A 2P3UA 3DEMA 4RUTA 1IQFL 2KL7A 3LC5B 4NG9L 2VWOL 1OB1C 3ZYJB 2W3IB 1APQA 3F6UL 5JBAE 2BQWA 2KB9A 2XC0L 4G1MB 4A94C 4ZXYL 1F7MA 3NTBA 4RRWA 3NT1A 1YUKB 2YGQA 1IOEL 3GCWE 3TK5B 1FF7A 2G00L 4RRZA 1Q4GA 4JYVL 1ATDA 1DDXA 1M1XB 1QFKL 4JYUL 4COXA 3HS7A 2JJLA 5JVYA 4X8TL 4X8SL 2EI6B 4Z0KB 4JZEL 2WFXB 1RFNB 4MMYB 3HPTA 2P16L 2Y7XB 4ZH8B 2OYEP 1UZPA 4Z0LA 1ATEA 2AYLA 3RR3A 1JBUL 2MHPA 1TPGA 1NT0A 3GISX 1IQLL 1G1QA 2BZ6L 2VWMK 3M37L 5F19A 4ISHL 2P28B 1EQHA 3C9AC 1IQIL 1NFUB 3BPSE 1V1IA 1LMMA 3FCSB 4XL1A 1P9JA 5IKVA 5IKQA 1Z6EL 3QMOA 2XBWL 3LN1A 1PGEA 5I46L 3TGFA 1PFXL 1APOA 1QIUA 1A3PA 1CCFA 2VWNL 3MQEA 1U8CB 1IGXA 1X7AL 4YZUB 2Q1JB 6COXA 1ATAA 2BQ7A 1WHEA 2VVCK 1UZQA 1IQHL 1KLOA 1XDTR 3SW2A 3CENL 2WPIE 1URKA 5JBCE 3HS5A 2VH0B 2VWLL 5EGMB 1IQNL 3KRKA 2W2QE 4LMFA 4Y71B 3N8ZA 1HX2A 1HRFA 1K37A 2P93L 3ZYIB 1CQEA 2GD4A 4CUEA 1EPGA 1FSBA 2ADXA 1IQGL 2HOXA 2BOUA 4MMXB 2FLRL 4LORA 2P26A 4RRYA 3CA7A 2XBYL 1IVOC 3Q7DA 2H9EC 3KCGL 3SOQA 1LMJA 2KV4A 2J94B 1WHFA 4ZAEB 2EI8B 4O1ZA 1LPKA 2WPKE 1HT8A 2F9BL 1TOZA 2JKHL 1MQ6L 2TGFA 1NQLB 2NPRA 1G1RA 3KL6B 1EBVA 2HORA 4CUFA 1XFEA 2K2TA 3N8YA 1AUTL 3N8WB 3H5CB 4RS0A 5F1AA 1EAIC 1J9CL 3MDLA 3SOVA 2WPJE 1G1TA 2VVVL 4M10A 4CUDA 5E8DA 1UZJA 1Z6CA 2P94L 4D0FA 3LTGD 2OYUP 1HREA 5KIRA 2BT7A 3ENSA 1KKEA 1EQGA 4D0EA 4BDXA 4E1GA 2BOHA 3IITB 4Y76B 2WPHE 3TH3L 2J4IB 1KLJL 1I0UA 2XC5L 1G1SA 2MGRA 1U67A 1LPZA 1EGFA 4X8VL 4D90A 5K0HB 2VRSA 3N8YB 5CISA 3SOBB 3U73A 3V65B 1MQ5L 1SZBA 3Q3KB 2WG3C 1LQDA 3KQDL 5JB8E 1NZIA 1IGZA 5CKQA 1JL9A 3TBDA 1NFXB 2UWOB 3ZYGA 1EPIA 2Y38A 3GCXE 1CVWL 3K9XA 5JB9E 2PHBB 4Y7AB 2J2UB 1LPGA 2D1JB 5JVZA 1EPJA 4AQTA 3POYA 3ASIA 2PR3B 2BOKL 2M74A 1FAXL 3NJPC 4M11A 4RRXA 3HO4A 1HJ7A 2P3FL 1P0SL 1EZQB 1N1IA 1K36A 1B9WA 1N7DA 4BTIA 1LK9A 4X8UL 4CSYA 5CKNA 2WZPP 2RNLA 4NA9L 4Y79B 1F7EA 1WU1B 2XBVL 1PRHA 1ZAQA 4Z6AL 5FDQA 3HO3A 2MGPA 3QCWA 3N8XA 3F1SB 2Y5GL 1XKAL 5KN5C 3LN0A 2P3FN 1EMNA 3OLUA 2FLGA 3BT2A 1FFMA 1JV2B 2H9EL 2P3TA 5COXA 3QH0A 2Y81B 1KIGL 2J34B 1PXXA 1YGCL 4JZFL 1YUGA 3S6XA 4XLWA 2PUQL 4BXWA 1ATBA 4BTTA 2I9AA 1NFYB 4ZXXL 3IJEB 3CFWA 1UZKA 1TLEA 2Y5FL 2YGOA 2YGPA 2Y80B 1KSNB 2VJ3A 3R05A 2W2OE 2BT8A 3LTFB 4O02B 1NFWB 5CKMA 1FJSL 2WG4B 4FM5A 4BXSA 1PTHA 1KLIL 1DX5I 3U7UG 1HCGB 1HZ8A 4OTJA 4NGAL 3NTGA 2W2NE 1BF9A 3V64C 1YUFA 1G2MB 5L2ZL 3M36L 2Y82B 1V1HA 2WYGB 5IKTA 2XC4L 1HAEA 3TZIA 1MOXC 1CVUA 2K2SB 2EI7B 1EPHA 2WPLE 2W86A 1NPEB 4XBMA 2UWLB 3PGHA 4YT7L 2BO2A 1IQML 1DIYA 3KQEL 3KK6A 1CX2A 4ZHAB 1EMOA 3OLTA 2Y5HL 3HO5A 3LIWB
chains in the Genus database with same CATH topology
2J95B 1C5MF 4BTUA 3KQBL 1F0SB 4OTYA 1IQKL 3BT1A 2WFTA 1L5GB 2W2PE 1YO8A 3CS7L 3KQCL 5IKRA 2I9BA 4TGFA 3EGFA 2P95L 1IQEL 1FAKL 1DVAL 2DDUA 4A7IA 1G2LB 1IP0A 4Y6DB 2BQ6A 1CEJA 2FZZL 2J38B 2VVUL 2W3KB 1V3XB 1F0RB 4ISIL 3LC3B 2FD6A 1FE2A 4BDWA 1W7XL 1HAFA 5L30L 2XBXL 3ELAL 4PH9A 1L3YA 1IQJL 1ADXA 3FBYA 5JW1A 1XKBA 2B7DL 1HT5A 3P5BL 2CJIB 1COUA 4YT6L 2FLBL 2RA0L 2BOXA 2WYJB 2Y7ZB 2KNIA 5L2YL 2WPME 3N8WA 1IJQA 1W8BL 4MMZB 1GK5A 4JZDL 2W26B 5JBBE 2W2ME 4Y7BB 3TK6B 1IOXA 1DQBA 3LAQA 2VH6B 1CCVA 4C16A 1O5DL 2RHPA 2UWPB 3N8VA 3FFGL 2BMGA 3HS6A 2P3UA 3DEMA 4RUTA 1IQFL 2KL7A 3LC5B 4NG9L 2VWOL 1OB1C 3ZYJB 2W3IB 1APQA 3F6UL 5JBAE 2BQWA 2KB9A 2XC0L 4G1MB 4A94C 4ZXYL 1F7MA 3NTBA 4RRWA 3NT1A 1YUKB 2YGQA 1IOEL 3GCWE 3TK5B 1FF7A 2G00L 4RRZA 1Q4GA 4JYVL 1ATDA 1DDXA 1M1XB 1QFKL 4JYUL 4COXA 3HS7A 5JVYA 4X8TL 4X8SL 2EI6B 4Z0KB 4JZEL 2WFXB 1RFNB 4MMYB 3HPTA 2P16L 2Y7XB 4ZH8B 2OYEP 1UZPA 4Z0LA 1ATEA 2AYLA 3RR3A 1JBUL 2MHPA 1TPGA 1NT0A 3GISX 1IQLL 1G1QA 2BZ6L 2VWMK 3M37L 5F19A 4ISHL 2P28B 1EQHA 3C9AC 1IQIL 1NFUB 3BPSE 1LMMA 3FCSB 4XL1A 1P9JA 5IKVA 5IKQA 1Z6EL 3QMOA 2XBWL 3LN1A 1PGEA 5I46L 3TGFA 1PFXL 1APOA 1A3PA 1CCFA 2VWNL 3MQEA 1U8CB 1IGXA 1X7AL 4YZUB 2Q1JB 6COXA 1ATAA 2BQ7A 1WHEA 2VVCK 1UZQA 1IQHL 1KLOA 1XDTR 3SW2A 3CENL 2WPIE 1URKA 5JBCE 3HS5A 2VH0B 2VWLL 5EGMB 1IQNL 3KRKA 2W2QE 4LMFA 4Y71B 3N8ZA 1HX2A 1HRFA 1K37A 2P93L 3ZYIB 1CQEA 2GD4A 4CUEA 1EPGA 1FSBA 2ADXA 1IQGL 2BOUA 4MMXB 2FLRL 4LORA 2P26A 4RRYA 3CA7A 2XBYL 1IVOC 3Q7DA 2H9EC 3KCGL 3SOQA 1LMJA 2KV4A 2J94B 1WHFA 4ZAEB 2EI8B 4O1ZA 1LPKA 2WPKE 1HT8A 2F9BL 1TOZA 2JKHL 1MQ6L 2TGFA 1NQLB 2NPRA 1G1RA 3KL6B 1EBVA 4CUFA 1XFEA 2K2TA 3N8YA 1AUTL 3N8WB 3H5CB 4RS0A 5F1AA 1EAIC 1J9CL 3MDLA 3SOVA 2WPJE 1G1TA 2VVVL 4M10A 4CUDA 5E8DA 1UZJA 1Z6CA 2P94L 4D0FA 3LTGD 2OYUP 1HREA 5KIRA 3ENSA 1EQGA 4D0EA 4BDXA 4E1GA 2BOHA 3IITB 4Y76B 2WPHE 3TH3L 2J4IB 1KLJL 1I0UA 2XC5L 1G1SA 2MGRA 1U67A 1LPZA 1EGFA 4X8VL 4D90A 5K0HB 3N8YB 5CISA 3SOBB 3U73A 3V65B 1MQ5L 1SZBA 3Q3KB 2WG3C 1LQDA 3KQDL 5JB8E 1NZIA 1IGZA 5CKQA 1JL9A 3TBDA 1NFXB 2UWOB 3ZYGA 1EPIA 2Y38A 3GCXE 1CVWL 3K9XA 5JB9E 2PHBB 4Y7AB 2J2UB 1LPGA 2D1JB 5JVZA 1EPJA 4AQTA 3POYA 3ASIA 2PR3B 2BOKL 2M74A 1FAXL 3NJPC 4M11A 4RRXA 3HO4A 1HJ7A 2P3FL 1P0SL 1EZQB 1N1IA 1K36A 1B9WA 1N7DA 4BTIA 4X8UL 4CSYA 5CKNA 2WZPP 2RNLA 4NA9L 4Y79B 1F7EA 1WU1B 2XBVL 1PRHA 1ZAQA 4Z6AL 5FDQA 3HO3A 2MGPA 3QCWA 3N8XA 3F1SB 2Y5GL 1XKAL 5KN5C 3LN0A 2P3FN 1EMNA 3OLUA 2FLGA 3BT2A 1FFMA 1JV2B 2H9EL 2P3TA 5COXA 3QH0A 2Y81B 1KIGL 2J34B 1PXXA 1YGCL 4JZFL 1YUGA 3S6XA 4XLWA 2PUQL 4BXWA 1ATBA 4BTTA 2I9AA 1NFYB 4ZXXL 3IJEB 3CFWA 1UZKA 1TLEA 2Y5FL 2YGOA 2YGPA 2Y80B 1KSNB 2VJ3A 3R05A 2W2OE 3LTFB 4O02B 1NFWB 5CKMA 1FJSL 2WG4B 4FM5A 4BXSA 1PTHA 1KLIL 1DX5I 3U7UG 1HCGB 1HZ8A 4OTJA 4NGAL 3NTGA 2W2NE 1BF9A 3V64C 1YUFA 1G2MB 5L2ZL 3M36L 2Y82B 2WYGB 5IKTA 2XC4L 1HAEA 3TZIA 1MOXC 1CVUA 2K2SB 2EI7B 1EPHA 2WPLE 2W86A 1NPEB 4XBMA 2UWLB 3PGHA 4YT7L 2BO2A 1IQML 1DIYA 3KQEL 3KK6A 1CX2A 4ZHAB 1EMOA 3OLTA 2Y5HL 3HO5A 3LIWB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2J95 B;  1C5M F;  4BTU A;  3KQB L;  1F0S B;  4OTY A;  1IQK L;  3BT1 A;  2WFT A;  1L5G B;  2W2P E;  1YO8 A;  3CS7 L;  3KQC L;  5IKR A;  2I9B A;  4TGF A;  3EGF A;  2P95 L;  1IQE L;  1FAK L;  1DVA L;  2DDU A;  4A7I A;  1G2L B;  1IP0 A;  4Y6D B;  2BQ6 A;  1CEJ A;  2FZZ L;  2J38 B;  2VVU L;  2W3K B;  1V3X B;  1F0R B;  4ISI L;  3LC3 B;  2FD6 A;  1FE2 A;  4BDW A;  1W7X L;  1HAF A;  5L30 L;  2XBX L;  3ELA L;  4PH9 A;  1L3Y A;  1IQJ L;  1ADX A;  3FBY A;  5JW1 A;  1XKB A;  2B7D L;  1HT5 A;  3P5B L;  2CJI B;  1COU A;  4YT6 L;  2FLB L;  2RA0 L;  2BOX A;  2WYJ B;  2Y7Z B;  5L2Y L;  2WPM E;  3N8W A;  1IJQ A;  1W8B L;  4MMZ B;  1GK5 A;  4JZD L;  2W26 B;  5JBB E;  2W2M E;  4Y7B B;  3TK6 B;  1IOX A;  1DQB A;  3LAQ A;  2VH6 B;  1CCV A;  4C16 A;  1O5D L;  2RHP A;  2UWP B;  3N8V A;  3FFG L;  2BMG A;  3HS6 A;  2P3U A;  3DEM A;  4RUT A;  1IQF L;  2KL7 A;  3LC5 B;  4NG9 L;  2VWO L;  1OB1 C;  3ZYJ B;  2W3I B;  1APQ A;  3F6U L;  5JBA E;  2BQW A;  2KB9 A;  2XC0 L;  4G1M B;  4ZXY L;  1F7M A;  3NTB A;  4RRW A;  3NT1 A;  1YUK B;  1IOE L;  3GCW E;  3TK5 B;  1FF7 A;  2G00 L;  4RRZ A;  1Q4G A;  4JYV L;  1ATD A;  1DDX A;  1M1X B;  1QFK L;  4JYU L;  4COX A;  3HS7 A;  5JVY A;  4X8T L;  4X8S L;  2EI6 B;  4Z0K B;  4JZE L;  2WFX B;  1RFN B;  4MMY B;  3HPT A;  2P16 L;  2Y7X B;  4ZH8 B;  2OYE P;  1UZP A;  4Z0L A;  1ATE A;  2AYL A;  3RR3 A;  1JBU L;  2MHP A;  1TPG A;  1NT0 A;  3GIS X;  1IQL L;  1G1Q A;  2BZ6 L;  2VWM K;  3M37 L;  5F19 A;  4ISH L;  2P28 B;  1EQH A;  3C9A C;  1IQI L;  1NFU B;  3BPS E;  3FCS B;  4XL1 A;  1P9J A;  5IKV A;  5IKQ A;  1Z6E L;  3QMO A;  2XBW L;  3LN1 A;  1PGE A;  5I46 L;  3TGF A;  1PFX L;  1APO A;  1A3P A;  1CCF A;  2VWN L;  3MQE A;  1U8C B;  1IGX A;  1X7A L;  4YZU B;  2Q1J B;  6COX A;  1ATA A;  2BQ7 A;  1WHE A;  2VVC K;  1UZQ A;  1IQH L;  1KLO A;  1XDT R;  3SW2 A;  3CEN L;  2WPI E;  1URK A;  5JBC E;  3HS5 A;  2VH0 B;  2VWL L;  5EGM B;  1IQN L;  3KRK A;  2W2Q E;  4LMF A;  4Y71 B;  3N8Z A;  1HX2 A;  1HRF A;  1K37 A;  2P93 L;  3ZYI B;  1CQE A;  2GD4 A;  4CUE A;  1EPG A;  1FSB A;  2ADX A;  1IQG L;  2BOU A;  4MMX B;  2FLR L;  4LOR A;  2P26 A;  4RRY A;  3CA7 A;  2XBY L;  1IVO C;  3Q7D A;  3SOQ A;  3KCG L;  1LMJ A;  2KV4 A;  2J94 B;  1WHF A;  4ZAE B;  2EI8 B;  4O1Z A;  1LPK A;  2WPK E;  1HT8 A;  2F9B L;  1TOZ A;  2JKH L;  1MQ6 L;  2TGF A;  1NQL B;  2NPR A;  1G1R A;  3KL6 B;  1EBV A;  4CUF A;  1XFE A;  2K2T A;  3N8Y A;  1AUT L;  3N8W B;  3H5C B;  4RS0 A;  5F1A A;  1EAI C;  1J9C L;  3MDL A;  3SOV A;  2WPJ E;  1G1T A;  2VVV L;  4M10 A;  4CUD A;  5E8D A;  1UZJ A;  1Z6C A;  2P94 L;  4D0F A;  3LTG D;  2OYU P;  1HRE A;  5KIR A;  3ENS A;  1EQG A;  4D0E A;  4BDX A;  4E1G A;  2BOH A;  3IIT B;  4Y76 B;  2WPH E;  3TH3 L;  2J4I B;  1KLJ L;  1I0U A;  2XC5 L;  1G1S A;  2MGR A;  1U67 A;  1LPZ A;  1EGF A;  4X8V L;  4D90 A;  5K0H B;  3N8Y B;  5CIS A;  3SOB B;  3U73 A;  3V65 B;  1MQ5 L;  1SZB A;  3Q3K B;  2WG3 C;  1LQD A;  3KQD L;  5JB8 E;  1NZI A;  1IGZ A;  5CKQ A;  1JL9 A;  3TBD A;  1NFX B;  2UWO B;  3ZYG A;  1EPI A;  2Y38 A;  3GCX E;  1CVW L;  3K9X A;  5JB9 E;  2PHB B;  4Y7A B;  2J2U B;  1LPG A;  2D1J B;  5JVZ A;  1EPJ A;  4AQT A;  3POY A;  3ASI A;  2PR3 B;  2BOK L;  2M74 A;  1FAX L;  3NJP C;  4M11 A;  4RRX A;  3HO4 A;  1HJ7 A;  2P3F L;  1P0S L;  1EZQ B;  1N1I A;  1K36 A;  1B9W A;  1N7D A;  4BTI A;  4X8U L;  4CSY A;  5CKN A;  2RNL A;  4NA9 L;  4Y79 B;  1F7E A;  1WU1 B;  2XBV L;  1PRH A;  1ZAQ A;  4Z6A L;  5FDQ A;  3HO3 A;  2MGP A;  3QCW A;  3N8X A;  3F1S B;  2Y5G L;  1XKA L;  5KN5 C;  3LN0 A;  2P3F N;  1EMN A;  3OLU A;  2FLG A;  3BT2 A;  1FFM A;  1JV2 B;  2H9E L;  2P3T A;  5COX A;  3QH0 A;  2Y81 B;  1KIG L;  2J34 B;  1PXX A;  1YGC L;  4JZF L;  1YUG A;  4XLW A;  2PUQ L;  4BXW A;  1ATB A;  4BTT A;  2I9A A;  1NFY B;  4ZXX L;  3IJE B;  3CFW A;  1UZK A;  1TLE A;  2Y5F L;  2YGO A;  2YGP A;  2Y80 B;  1KSN B;  2VJ3 A;  3R05 A;  2W2O E;  3LTF B;  4O02 B;  1NFW B;  5CKM A;  1FJS L;  2WG4 B;  4FM5 A;  4BXS A;  1PTH A;  1KLI L;  1DX5 I;  3U7U G;  1HCG B;  1HZ8 A;  4OTJ A;  4NGA L;  3NTG A;  2W2N E;  1BF9 A;  3V64 C;  1YUF A;  1G2M B;  5L2Z L;  3M36 L;  2Y82 B;  2WYG B;  5IKT A;  2XC4 L;  1HAE A;  3TZI A;  1MOX C;  1CVU A;  2K2S B;  2EI7 B;  1EPH A;  2WPL E;  2W86 A;  1NPE B;  4XBM A;  2UWL B;  3PGH A;  4YT7 L;  2BO2 A;  1IQM L;  1DIY A;  3KQE L;  3KK6 A;  1CX2 A;  4ZHA B;  1EMO A;  3OLT A;  2Y5H L;  3HO5 A;  3LIW B; 
#chains in the Genus database with same CATH topology
 2J95 B;  1C5M F;  4BTU A;  3KQB L;  1F0S B;  4OTY A;  1IQK L;  3BT1 A;  2WFT A;  1L5G B;  2W2P E;  1YO8 A;  3CS7 L;  3KQC L;  5IKR A;  2I9B A;  4TGF A;  3EGF A;  4GU4 A;  2P95 L;  4GU3 A;  1IQE L;  1FAK L;  1DVA L;  2DDU A;  4A7I A;  1G2L B;  1IP0 A;  4Y6D B;  2BQ6 A;  1CEJ A;  2FZZ L;  2J38 B;  2VVU L;  2W3K B;  1V3X B;  1F0R B;  4ISI L;  3LC3 B;  2FD6 A;  2BSF A;  1FE2 A;  4BDW A;  1W7X L;  1HAF A;  5L30 L;  2XBX L;  3ELA L;  4PH9 A;  1L3Y A;  1IQJ L;  1ADX A;  3FBY A;  5JW1 A;  1XKB A;  2B7D L;  1HT5 A;  3P5B L;  2CJI B;  1COU A;  4YT6 L;  2FLB L;  2RA0 L;  2BOX A;  2WYJ B;  2Y7Z B;  2KNI A;  5L2Y L;  2WPM E;  3N8W A;  1IJQ A;  1W8B L;  4MMZ B;  1GK5 A;  4JZD L;  2W26 B;  5JBB E;  2W2M E;  4Y7B B;  3TK6 B;  1IOX A;  1DQB A;  3LAQ A;  2VH6 B;  1CCV A;  4C16 A;  1O5D L;  2RHP A;  2UWP B;  3N8V A;  3FFG L;  2BMG A;  3HS6 A;  2P3U A;  3DEM A;  4RUT A;  1IQF L;  2KL7 A;  3LC5 B;  4NG9 L;  2VWO L;  1OB1 C;  3ZYJ B;  2W3I B;  1APQ A;  3F6U L;  5JBA E;  2BQW A;  2KB9 A;  2XC0 L;  4G1M B;  4A94 C;  4ZXY L;  1F7M A;  3NTB A;  4RRW A;  3NT1 A;  1YUK B;  2YGQ A;  1IOE L;  3GCW E;  3TK5 B;  1FF7 A;  2G00 L;  4RRZ A;  1Q4G A;  4JYV L;  1ATD A;  1DDX A;  1M1X B;  1QFK L;  4JYU L;  4COX A;  3HS7 A;  2JJL A;  5JVY A;  4X8T L;  4X8S L;  2EI6 B;  4Z0K B;  4JZE L;  2WFX B;  1RFN B;  4MMY B;  3HPT A;  2P16 L;  2Y7X B;  4ZH8 B;  2OYE P;  1UZP A;  4Z0L A;  1ATE A;  2AYL A;  3RR3 A;  1JBU L;  2MHP A;  1TPG A;  1NT0 A;  3GIS X;  1IQL L;  1G1Q A;  2BZ6 L;  2VWM K;  3M37 L;  5F19 A;  4ISH L;  2P28 B;  1EQH A;  3C9A C;  1IQI L;  1NFU B;  3BPS E;  1V1I A;  1LMM A;  3FCS B;  4XL1 A;  1P9J A;  5IKV A;  5IKQ A;  1Z6E L;  3QMO A;  2XBW L;  3LN1 A;  1PGE A;  5I46 L;  3TGF A;  1PFX L;  1APO A;  1QIU A;  1A3P A;  1CCF A;  2VWN L;  3MQE A;  1U8C B;  1IGX A;  1X7A L;  4YZU B;  2Q1J B;  6COX A;  1ATA A;  2BQ7 A;  1WHE A;  2VVC K;  1UZQ A;  1IQH L;  1KLO A;  1XDT R;  3SW2 A;  3CEN L;  2WPI E;  1URK A;  5JBC E;  3HS5 A;  2VH0 B;  2VWL L;  5EGM B;  1IQN L;  3KRK A;  2W2Q E;  4LMF A;  4Y71 B;  3N8Z A;  1HX2 A;  1HRF A;  1K37 A;  2P93 L;  3ZYI B;  1CQE A;  2GD4 A;  4CUE A;  1EPG A;  1FSB A;  2ADX A;  1IQG L;  2HOX A;  2BOU A;  4MMX B;  2FLR L;  4LOR A;  2P26 A;  4RRY A;  3CA7 A;  2XBY L;  1IVO C;  3Q7D A;  2H9E C;  3KCG L;  3SOQ A;  1LMJ A;  2KV4 A;  2J94 B;  1WHF A;  4ZAE B;  2EI8 B;  4O1Z A;  1LPK A;  2WPK E;  1HT8 A;  2F9B L;  1TOZ A;  2JKH L;  1MQ6 L;  2TGF A;  1NQL B;  2NPR A;  1G1R A;  3KL6 B;  1EBV A;  2HOR A;  4CUF A;  1XFE A;  2K2T A;  3N8Y A;  1AUT L;  3N8W B;  3H5C B;  4RS0 A;  5F1A A;  1EAI C;  1J9C L;  3MDL A;  3SOV A;  2WPJ E;  1G1T A;  2VVV L;  4M10 A;  4CUD A;  5E8D A;  1UZJ A;  1Z6C A;  2P94 L;  4D0F A;  3LTG D;  2OYU P;  1HRE A;  5KIR A;  2BT7 A;  3ENS A;  1KKE A;  1EQG A;  4D0E A;  4BDX A;  4E1G A;  2BOH A;  3IIT B;  4Y76 B;  2WPH E;  3TH3 L;  2J4I B;  1KLJ L;  1I0U A;  2XC5 L;  1G1S A;  2MGR A;  1U67 A;  1LPZ A;  1EGF A;  4X8V L;  4D90 A;  5K0H B;  2VRS A;  3N8Y B;  5CIS A;  3SOB B;  3U73 A;  3V65 B;  1MQ5 L;  1SZB A;  3Q3K B;  2WG3 C;  1LQD A;  3KQD L;  5JB8 E;  1NZI A;  1IGZ A;  5CKQ A;  1JL9 A;  3TBD A;  1NFX B;  2UWO B;  3ZYG A;  1EPI A;  2Y38 A;  3GCX E;  1CVW L;  3K9X A;  5JB9 E;  2PHB B;  4Y7A B;  2J2U B;  1LPG A;  2D1J B;  5JVZ A;  1EPJ A;  4AQT A;  3POY A;  3ASI A;  2PR3 B;  2BOK L;  2M74 A;  1FAX L;  3NJP C;  4M11 A;  4RRX A;  3HO4 A;  1HJ7 A;  2P3F L;  1P0S L;  1EZQ B;  1N1I A;  1K36 A;  1B9W A;  1N7D A;  4BTI A;  1LK9 A;  4X8U L;  4CSY A;  5CKN A;  2WZP P;  2RNL A;  4NA9 L;  4Y79 B;  1F7E A;  1WU1 B;  2XBV L;  1PRH A;  1ZAQ A;  4Z6A L;  5FDQ A;  3HO3 A;  2MGP A;  3QCW A;  3N8X A;  3F1S B;  2Y5G L;  1XKA L;  5KN5 C;  3LN0 A;  2P3F N;  1EMN A;  3OLU A;  2FLG A;  3BT2 A;  1FFM A;  1JV2 B;  2H9E L;  2P3T A;  5COX A;  3QH0 A;  2Y81 B;  1KIG L;  2J34 B;  1PXX A;  1YGC L;  4JZF L;  1YUG A;  3S6X A;  4XLW A;  2PUQ L;  4BXW A;  1ATB A;  4BTT A;  2I9A A;  1NFY B;  4ZXX L;  3IJE B;  3CFW A;  1UZK A;  1TLE A;  2Y5F L;  2YGO A;  2YGP A;  2Y80 B;  1KSN B;  2VJ3 A;  3R05 A;  2W2O E;  2BT8 A;  3LTF B;  4O02 B;  1NFW B;  5CKM A;  1FJS L;  2WG4 B;  4FM5 A;  4BXS A;  1PTH A;  1KLI L;  1DX5 I;  3U7U G;  1HCG B;  1HZ8 A;  4OTJ A;  4NGA L;  3NTG A;  2W2N E;  1BF9 A;  3V64 C;  1YUF A;  1G2M B;  5L2Z L;  3M36 L;  2Y82 B;  1V1H A;  2WYG B;  5IKT A;  2XC4 L;  1HAE A;  3TZI A;  1MOX C;  1CVU A;  2K2S B;  2EI7 B;  1EPH A;  2WPL E;  2W86 A;  1NPE B;  4XBM A;  2UWL B;  3PGH A;  4YT7 L;  2BO2 A;  1IQM L;  1DIY A;  3KQE L;  3KK6 A;  1CX2 A;  4ZHA B;  1EMO A;  3OLT A;  2Y5H L;  3HO5 A;  3LIW B; 
#chains in the Genus database with same CATH homology
 2J95 B;  1C5M F;  4BTU A;  3KQB L;  1F0S B;  4OTY A;  1IQK L;  3BT1 A;  2WFT A;  1L5G B;  2W2P E;  1YO8 A;  3CS7 L;  3KQC L;  5IKR A;  2I9B A;  4TGF A;  3EGF A;  2P95 L;  1IQE L;  1FAK L;  1DVA L;  2DDU A;  4A7I A;  1G2L B;  1IP0 A;  4Y6D B;  2BQ6 A;  1CEJ A;  2FZZ L;  2J38 B;  2VVU L;  2W3K B;  1V3X B;  1F0R B;  4ISI L;  3LC3 B;  2FD6 A;  1FE2 A;  4BDW A;  1W7X L;  1HAF A;  5L30 L;  2XBX L;  3ELA L;  4PH9 A;  1L3Y A;  1IQJ L;  1ADX A;  3FBY A;  5JW1 A;  1XKB A;  2B7D L;  1HT5 A;  3P5B L;  2CJI B;  1COU A;  4YT6 L;  2FLB L;  2RA0 L;  2BOX A;  2WYJ B;  2Y7Z B;  2KNI A;  5L2Y L;  2WPM E;  3N8W A;  1IJQ A;  1W8B L;  4MMZ B;  1GK5 A;  4JZD L;  2W26 B;  5JBB E;  2W2M E;  4Y7B B;  3TK6 B;  1IOX A;  1DQB A;  3LAQ A;  2VH6 B;  1CCV A;  4C16 A;  1O5D L;  2RHP A;  2UWP B;  3N8V A;  3FFG L;  2BMG A;  3HS6 A;  2P3U A;  3DEM A;  4RUT A;  1IQF L;  2KL7 A;  3LC5 B;  4NG9 L;  2VWO L;  1OB1 C;  3ZYJ B;  2W3I B;  1APQ A;  3F6U L;  5JBA E;  2BQW A;  2KB9 A;  2XC0 L;  4G1M B;  4A94 C;  4ZXY L;  1F7M A;  3NTB A;  4RRW A;  3NT1 A;  1YUK B;  2YGQ A;  1IOE L;  3GCW E;  3TK5 B;  1FF7 A;  2G00 L;  4RRZ A;  1Q4G A;  4JYV L;  1ATD A;  1DDX A;  1M1X B;  1QFK L;  4JYU L;  4COX A;  3HS7 A;  5JVY A;  4X8T L;  4X8S L;  2EI6 B;  4Z0K B;  4JZE L;  2WFX B;  1RFN B;  4MMY B;  3HPT A;  2P16 L;  2Y7X B;  4ZH8 B;  2OYE P;  1UZP A;  4Z0L A;  1ATE A;  2AYL A;  3RR3 A;  1JBU L;  2MHP A;  1TPG A;  1NT0 A;  3GIS X;  1IQL L;  1G1Q A;  2BZ6 L;  2VWM K;  3M37 L;  5F19 A;  4ISH L;  2P28 B;  1EQH A;  3C9A C;  1IQI L;  1NFU B;  3BPS E;  1LMM A;  3FCS B;  4XL1 A;  1P9J A;  5IKV A;  5IKQ A;  1Z6E L;  3QMO A;  2XBW L;  3LN1 A;  1PGE A;  5I46 L;  3TGF A;  1PFX L;  1APO A;  1A3P A;  1CCF A;  2VWN L;  3MQE A;  1U8C B;  1IGX A;  1X7A L;  4YZU B;  2Q1J B;  6COX A;  1ATA A;  2BQ7 A;  1WHE A;  2VVC K;  1UZQ A;  1IQH L;  1KLO A;  1XDT R;  3SW2 A;  3CEN L;  2WPI E;  1URK A;  5JBC E;  3HS5 A;  2VH0 B;  2VWL L;  5EGM B;  1IQN L;  3KRK A;  2W2Q E;  4LMF A;  4Y71 B;  3N8Z A;  1HX2 A;  1HRF A;  1K37 A;  2P93 L;  3ZYI B;  1CQE A;  2GD4 A;  4CUE A;  1EPG A;  1FSB A;  2ADX A;  1IQG L;  2BOU A;  4MMX B;  2FLR L;  4LOR A;  2P26 A;  4RRY A;  3CA7 A;  2XBY L;  1IVO C;  3Q7D A;  2H9E C;  3KCG L;  3SOQ A;  1LMJ A;  2KV4 A;  2J94 B;  1WHF A;  4ZAE B;  2EI8 B;  4O1Z A;  1LPK A;  2WPK E;  1HT8 A;  2F9B L;  1TOZ A;  2JKH L;  1MQ6 L;  2TGF A;  1NQL B;  2NPR A;  1G1R A;  3KL6 B;  1EBV A;  4CUF A;  1XFE A;  2K2T A;  3N8Y A;  1AUT L;  3N8W B;  3H5C B;  4RS0 A;  5F1A A;  1EAI C;  1J9C L;  3MDL A;  3SOV A;  2WPJ E;  1G1T A;  2VVV L;  4M10 A;  4CUD A;  5E8D A;  1UZJ A;  1Z6C A;  2P94 L;  4D0F A;  3LTG D;  2OYU P;  1HRE A;  5KIR A;  3ENS A;  1EQG A;  4D0E A;  4BDX A;  4E1G A;  2BOH A;  3IIT B;  4Y76 B;  2WPH E;  3TH3 L;  2J4I B;  1KLJ L;  1I0U A;  2XC5 L;  1G1S A;  2MGR A;  1U67 A;  1LPZ A;  1EGF A;  4X8V L;  4D90 A;  5K0H B;  3N8Y B;  5CIS A;  3SOB B;  3U73 A;  3V65 B;  1MQ5 L;  1SZB A;  3Q3K B;  2WG3 C;  1LQD A;  3KQD L;  5JB8 E;  1NZI A;  1IGZ A;  5CKQ A;  1JL9 A;  3TBD A;  1NFX B;  2UWO B;  3ZYG A;  1EPI A;  2Y38 A;  3GCX E;  1CVW L;  3K9X A;  5JB9 E;  2PHB B;  4Y7A B;  2J2U B;  1LPG A;  2D1J B;  5JVZ A;  1EPJ A;  4AQT A;  3POY A;  3ASI A;  2PR3 B;  2BOK L;  2M74 A;  1FAX L;  3NJP C;  4M11 A;  4RRX A;  3HO4 A;  1HJ7 A;  2P3F L;  1P0S L;  1EZQ B;  1N1I A;  1K36 A;  1B9W A;  1N7D A;  4BTI A;  4X8U L;  4CSY A;  5CKN A;  2WZP P;  2RNL A;  4NA9 L;  4Y79 B;  1F7E A;  1WU1 B;  2XBV L;  1PRH A;  1ZAQ A;  4Z6A L;  5FDQ A;  3HO3 A;  2MGP A;  3QCW A;  3N8X A;  3F1S B;  2Y5G L;  1XKA L;  5KN5 C;  3LN0 A;  2P3F N;  1EMN A;  3OLU A;  2FLG A;  3BT2 A;  1FFM A;  1JV2 B;  2H9E L;  2P3T A;  5COX A;  3QH0 A;  2Y81 B;  1KIG L;  2J34 B;  1PXX A;  1YGC L;  4JZF L;  1YUG A;  3S6X A;  4XLW A;  2PUQ L;  4BXW A;  1ATB A;  4BTT A;  2I9A A;  1NFY B;  4ZXX L;  3IJE B;  3CFW A;  1UZK A;  1TLE A;  2Y5F L;  2YGO A;  2YGP A;  2Y80 B;  1KSN B;  2VJ3 A;  3R05 A;  2W2O E;  3LTF B;  4O02 B;  1NFW B;  5CKM A;  1FJS L;  2WG4 B;  4FM5 A;  4BXS A;  1PTH A;  1KLI L;  1DX5 I;  3U7U G;  1HCG B;  1HZ8 A;  4OTJ A;  4NGA L;  3NTG A;  2W2N E;  1BF9 A;  3V64 C;  1YUF A;  1G2M B;  5L2Z L;  3M36 L;  2Y82 B;  2WYG B;  5IKT A;  2XC4 L;  1HAE A;  3TZI A;  1MOX C;  1CVU A;  2K2S B;  2EI7 B;  1EPH A;  2WPL E;  2W86 A;  1NPE B;  4XBM A;  2UWL B;  3PGH A;  4YT7 L;  2BO2 A;  1IQM L;  1DIY A;  3KQE L;  3KK6 A;  1CX2 A;  4ZHA B;  1EMO A;  3OLT A;  2Y5H L;  3HO5 A;  3LIW B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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