4ISHL

Structure of factor viia in complex with the inhibitor bms-593214 also known as 2'-[(6r,6ar,11br)-2-carbamimidoyl-6,6a,7,11b-tetrahydro-5h-indeno[2,1-c]quinolin-6-yl]-5'-hydroxy-4'-methoxybiphenyl-4-carboxylic acid
Total Genus 12
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
12
sequence length
55
structure length
55
Chain Sequence
ICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILEKR
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Discovery and gram-scale synthesis of BMS-593214, a potent, selective FVIIa inhibitor.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Homo sapiens
molecule keywords Factor VII heavy chain
total genus 12
structure length 55
sequence length 55
ec nomenclature ec 3.4.21.21: Coagulation factor VIIa.
pdb deposition date 2013-01-16
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.25.10 Mainly Beta Ribbon Laminin Laminin 4ishL00
1NT0A 4RRYA 2MGRA 3LN0A 1Z6EL 3QH0A 4XL1A 2BZ6L 1MOXC 2KV4A 2VH6B 1EPGA 1MQ6L 1U8CB 2RHPA 4D90A 2W3IB 4CUFA 3KQEL 4ZAEB 1XKAL 2KB9A 1OB1C 2J95B 3KCGL 3F6UL 3N8VA 3BPSE 3BT1A 3N8WB 3P5BL 5CKQA 3POYA 1IQML 3R05A 1UZKA 2UWLB 2AYLA 3Q7DA 4JZFL 1NFXB 1HZ8A 1LMJA 2OYEP 4ISHL 1G1QA 2Y7ZB 2PR3B 2P3TA 2I9AA 3K9XA 1L3YA 1W7XL 3KK6A 1EGFA 3BT2A 3NT1A 1ZAQA 1AUTL 1C5MF 5KN5C 4CSYA 2MGPA 1CX2A 5JVZA 4JYVL 1IQKL 2XC0L 3HO5A 2MHPA 2Y5GL 3ZYIB 2WG3C 1ATBA 3N8YA 5JVYA 1V3XB 2Y81B 3GCXE 2XBYL 1HAEA 2Y80B 2Y82B 1CEJA 4A7IA 1ADXA 5IKRA 2WYGB 4X8TL 4ISIL 1EQGA 1GK5A 4RUTA 4Z0LA 2VH0B 1PFXL 3IJEB 1ATEA 1U67A 2XBXL 4NGAL 2BOHA 1P0SL 1IQEL 4Y79B 1DVAL 4NG9L 2BMGA 1ATAA 1HRFA 1F0SB 2W26B 5IKQA 4BTTA 3LC5B 4COXA 3HPTA 1YGCL 1IVOC 1YUFA 3KRKA 1UZJA 1I0UA 5FDQA 3N8WA 4CUDA 1B9WA 2P28B 2BO2A 3LTFB 3N8XA 1K36A 2F9BL 4OTJA 3LAQA 4MMZB 2FZZL 2W2OE 2P95L 2W86A 3SOVA 3CA7A 3HO3A 3TK6B 2W2PE 2J2UB 3V65B 5L30L 1IGXA 2NPRA 3HO4A 4JZDL 1IQJL 1IOXA 3GCWE 1YUGA 5F19A 2WFXB 1M1XB 2M74A 3DEMA 4MMXB 6COXA 1N7DA 1JBUL 3NTBA 2CJIB 3ZYGA 4CUEA 5JB8E 4RS0A 1FE2A 3FFGL 4TGFA 1N1IA 3U7UG 4JZEL 1F7EA 3M36L 1APQA 1UZPA 1IGZA 2BOUA 2H9EL 4ZHAB 1HCGB 1FSBA 2WG4B 4RRXA 1W8BL 4M10A 2XBVL 4BXWA 1NFWB 3TK5B 1EMOA 1G2MB 2P3FN 1NPEB 1APOA 5JBAE 2TGFA 4OTYA 2PHBB 1HT5A 1YUKB 1JL9A 1NFUB 4O02B 4AQTA 1UZQA 3CFWA 3RR3A 4BTIA 4C16A 1FAXL 3HS5A 3LN1A 1LPGA 3KL6B 5JBBE 3FBYA 2WPKE 1YO8A 1IQNL 3IITB 4BXSA 3MQEA 4BDWA 4X8SL 2EI7B 5I46L 1KLOA 5E8DA 2VVVL 1CVWL 3SOBB 2WFTA 1URKA 1RFNB 1FAKL 1EAIC 1LPKA 2VVCK 2Y5HL 2RA0L 2XC4L 3HS7A 3C9AC 4LMFA 3TZIA 3TH3L 4YT6L 1JV2B 4X8UL 4G1MB 4Y7BB 2J34B 4YZUB 2D1JB 5JW1A 1EBVA 2FLGA 4Z6AL 2G00L 1IQGL 1DDXA 2I9BA 2Q1JB 4FM5A 3SOQA 2WYJB 2BOKL 3Q3KB 2ADXA 1COUA 1ATDA 3ASIA 3N8ZA 1XDTR 1G1SA 2KL7A 2J38B 1NQLB 1EZQB 1NZIA 1DQBA 4E1GA 3NTGA 5EGMB 1DIYA 1KSNB 2VVUL 2DDUA 1FJSL 2W2ME 1G2LB 2VJ3A 4X8VL 1EPIA 2J4IB 4BDXA 1HREA 3SW2A 1TPGA 4D0EA 1A3PA 1IJQA 1EPHA 1WHFA 1SZBA 3CS7L 5CKNA 2W2NE 4M11A 2EI6B 3LTGD 4ZXYL 3H5CB 4PH9A 1EPJA 1G1TA 4Z0KB 4RRWA 3MDLA 3KQDL 2P3UA 3FCSB 1EQHA 3KQBL 1L5GB 2P94L 2P16L 2WPJE 2Y38A 2BQ7A 3V64C 2XC5L 1HX2A 3GISX 3ELAL 2K2SB 2GD4A 1TLEA 2W2QE 2VWMK 1WHEA 1BF9A 1EMNA 3CENL 3ENSA 1PRHA 2WPIE 2P93L 3PGHA 1CVUA 2OYUP 1X7AL 4BTUA 3TGFA 2FD6A 1CCVA 3NJPC 4Y71B 4D0FA 2P26A 3M37L 4YT7L 4LORA 1J9CL 1XFEA 5CISA 3HS6A 1XKBA 2WPHE 1QFKL 1O5DL 4Y7AB 1HAFA 2BOXA 2B7DL 3LC3B 1TOZA 1HJ7A 2VWLL 2XBWL 1F7MA 3QMOA 1NFYB 2YGOA 4Y6DB 4XLWA 1KIGL 1PXXA 2UWPB 2Y5FL 5KIRA 1IOEL 1MQ5L 3LIWB 4JYUL 1LPZA 1P9JA 1F0RB 1CCFA 3QCWA 1IQIL 1KLJL 1K37A 3ZYJB 2VWOL 4ZH8B 2K2TA 3OLUA 2P3FL 5IKTA 4ZXXL 2BQ6A 1HT8A 2BQWA 2UWOB 5L2ZL 1IQLL 1IQHL 2W3KB 5F1AA 2FLRL 1CQEA 2WPLE 5K0HB 1LQDA 2RNLA 5CKMA 2EI8B 4Y76B 4XBMA 1WU1B 2YGPA 5JBCE 2Y7XB 1KLIL 4MMYB 1G1RA 5JB9E 3TBDA 1PGEA 1Q4GA 5IKVA 1IP0A 4RRZA 1FFMA 4O1ZA 1DX5I 2J94B 1IQFL 3N8YB 1PTHA 1Z6CA 2FLBL 2JKHL 2WPME 2PUQL 2VWNL 5L2YL 3U73A 3EGFA 5COXA 3KQCL 3F1SB 3OLTA 4NA9L 1FF7A
chains in the Genus database with same CATH superfamily
1NT0A 4RRYA 2MGRA 3LN0A 1Z6EL 3QH0A 4XL1A 2BZ6L 1MOXC 2KV4A 2VH6B 1EPGA 1MQ6L 1U8CB 2RHPA 4D90A 2W3IB 4CUFA 3KQEL 4ZAEB 1XKAL 2KB9A 1OB1C 2J95B 3KCGL 3F6UL 3N8VA 3BPSE 3BT1A 4A94C 3N8WB 3P5BL 5CKQA 3POYA 1IQML 3R05A 1UZKA 2UWLB 2AYLA 3Q7DA 4JZFL 1NFXB 1HZ8A 1LMJA 2OYEP 4ISHL 1G1QA 2Y7ZB 2PR3B 2P3TA 2I9AA 3K9XA 1L3YA 1W7XL 3KK6A 1EGFA 3BT2A 3NT1A 1ZAQA 1AUTL 1C5MF 5KN5C 4CSYA 2MGPA 1CX2A 5JVZA 4JYVL 1IQKL 2XC0L 3HO5A 2MHPA 2H9EC 2Y5GL 3ZYIB 2WG3C 1ATBA 3N8YA 5JVYA 1V3XB 2Y81B 3GCXE 2XBYL 1HAEA 2Y80B 2Y82B 1CEJA 4A7IA 1ADXA 5IKRA 2WYGB 4X8TL 4ISIL 1EQGA 1GK5A 4RUTA 4Z0LA 2VH0B 1QIUA 2HOXA 1PFXL 2KNIA 3IJEB 1ATEA 1U67A 2XBXL 4NGAL 2BOHA 1P0SL 1IQEL 4Y79B 1DVAL 4NG9L 2BMGA 1ATAA 1HRFA 1F0SB 2W26B 5IKQA 4BTTA 3LC5B 4COXA 3HPTA 1YGCL 1IVOC 1YUFA 3KRKA 1UZJA 1I0UA 5FDQA 3N8WA 4CUDA 1B9WA 2P28B 2BO2A 3LTFB 3N8XA 1K36A 2F9BL 4OTJA 3LAQA 4MMZB 2FZZL 2W2OE 2P95L 2W86A 3SOVA 3CA7A 3HO3A 3TK6B 2W2PE 2J2UB 3V65B 5L30L 1IGXA 2NPRA 3HO4A 2WZPP 4JZDL 1IQJL 1IOXA 3GCWE 1YUGA 5F19A 2WFXB 1M1XB 2M74A 3DEMA 4MMXB 6COXA 1KKEA 1N7DA 1JBUL 3NTBA 2CJIB 3ZYGA 4CUEA 5JB8E 4RS0A 1FE2A 3FFGL 4TGFA 1N1IA 3U7UG 4JZEL 1F7EA 3M36L 1APQA 1UZPA 1IGZA 2BOUA 2H9EL 4ZHAB 1HCGB 1FSBA 2WG4B 2BSFA 4RRXA 1W8BL 4M10A 2XBVL 4BXWA 1NFWB 3TK5B 1EMOA 1G2MB 2P3FN 1NPEB 1APOA 5JBAE 2TGFA 4OTYA 2PHBB 1HT5A 1V1IA 1YUKB 1JL9A 1NFUB 4O02B 4AQTA 1UZQA 3CFWA 3RR3A 4BTIA 4C16A 1FAXL 3HS5A 3LN1A 1LPGA 3KL6B 5JBBE 3FBYA 2WPKE 1YO8A 1IQNL 2VRSA 3IITB 4BXSA 3MQEA 4BDWA 4X8SL 2EI7B 5I46L 1KLOA 5E8DA 2VVVL 1CVWL 3SOBB 2WFTA 1URKA 1RFNB 1FAKL 1EAIC 1LPKA 2VVCK 2Y5HL 2RA0L 4GU4A 2XC4L 3HS7A 3C9AC 4LMFA 3TZIA 3TH3L 4YT6L 1JV2B 4X8UL 4G1MB 4Y7BB 2J34B 4YZUB 2D1JB 5JW1A 1EBVA 2FLGA 4Z6AL 2G00L 1IQGL 1DDXA 2I9BA 2Q1JB 4FM5A 3SOQA 2WYJB 2BOKL 3Q3KB 2ADXA 1COUA 1ATDA 3ASIA 3N8ZA 1XDTR 1G1SA 2KL7A 2J38B 1NQLB 1EZQB 1NZIA 1DQBA 4E1GA 3NTGA 5EGMB 1DIYA 1KSNB 2VVUL 2DDUA 1LK9A 1FJSL 2W2ME 1G2LB 2VJ3A 4X8VL 1EPIA 2J4IB 4BDXA 1HREA 3SW2A 1TPGA 4D0EA 1A3PA 1IJQA 1EPHA 1WHFA 1SZBA 3CS7L 5CKNA 1V1HA 2W2NE 4M11A 2EI6B 2HORA 3LTGD 4ZXYL 3H5CB 4PH9A 4GU3A 1EPJA 1G1TA 4Z0KB 4RRWA 3MDLA 3KQDL 2P3UA 3FCSB 1LMMA 1EQHA 3KQBL 1L5GB 2P94L 2P16L 2BT8A 2WPJE 2Y38A 2BQ7A 3V64C 2XC5L 1HX2A 3GISX 3ELAL 2K2SB 2GD4A 1TLEA 2W2QE 2VWMK 1WHEA 1BF9A 1EMNA 3CENL 3ENSA 1PRHA 2WPIE 2P93L 3PGHA 1CVUA 2OYUP 1X7AL 4BTUA 3TGFA 2FD6A 1CCVA 3NJPC 4Y71B 4D0FA 2P26A 3M37L 4YT7L 4LORA 1J9CL 1XFEA 5CISA 3HS6A 1XKBA 2WPHE 1QFKL 1O5DL 4Y7AB 1HAFA 2JJLA 2BOXA 2B7DL 3LC3B 1TOZA 1HJ7A 2VWLL 2XBWL 1F7MA 3QMOA 1NFYB 2YGOA 4Y6DB 4XLWA 1KIGL 1PXXA 2UWPB 2Y5FL 5KIRA 1IOEL 1MQ5L 3LIWB 4JYUL 1LPZA 1P9JA 3S6XA 1F0RB 1CCFA 3QCWA 1IQIL 1KLJL 1K37A 3ZYJB 2VWOL 4ZH8B 2K2TA 3OLUA 2P3FL 5IKTA 4ZXXL 2BQ6A 1HT8A 2BQWA 2UWOB 2BT7A 5L2ZL 1IQLL 1IQHL 2W3KB 5F1AA 2FLRL 1CQEA 2WPLE 5K0HB 1LQDA 2RNLA 5CKMA 2EI8B 4Y76B 4XBMA 1WU1B 2YGPA 5JBCE 2Y7XB 1KLIL 4MMYB 1G1RA 5JB9E 3TBDA 1PGEA 1Q4GA 5IKVA 1IP0A 4RRZA 1FFMA 4O1ZA 1DX5I 2J94B 1IQFL 3N8YB 1PTHA 1Z6CA 2FLBL 2JKHL 2YGQA 2WPME 2PUQL 2VWNL 5L2YL 3U73A 3EGFA 5COXA 3KQCL 3F1SB 3OLTA 4NA9L 1FF7A
chains in the Genus database with same CATH topology
1NT0A 4RRYA 2MGRA 3LN0A 1Z6EL 3QH0A 4XL1A 2BZ6L 1MOXC 2KV4A 2VH6B 1EPGA 1MQ6L 1U8CB 2RHPA 4D90A 2W3IB 4CUFA 3KQEL 4ZAEB 1XKAL 2KB9A 1OB1C 2J95B 3KCGL 3F6UL 3N8VA 3BPSE 3BT1A 4A94C 3N8WB 3P5BL 5CKQA 3POYA 1IQML 3R05A 1UZKA 2UWLB 2AYLA 3Q7DA 4JZFL 1NFXB 1HZ8A 1LMJA 2OYEP 4ISHL 1G1QA 2Y7ZB 2PR3B 2P3TA 2I9AA 3K9XA 1L3YA 1W7XL 3KK6A 1EGFA 3BT2A 3NT1A 1ZAQA 1AUTL 1C5MF 5KN5C 4CSYA 2MGPA 1CX2A 5JVZA 4JYVL 1IQKL 2XC0L 3HO5A 2MHPA 2H9EC 2Y5GL 3ZYIB 2WG3C 1ATBA 3N8YA 5JVYA 1V3XB 2Y81B 3GCXE 2XBYL 1HAEA 2Y80B 2Y82B 1CEJA 4A7IA 1ADXA 5IKRA 2WYGB 4X8TL 4ISIL 1EQGA 1GK5A 4RUTA 4Z0LA 2VH0B 1PFXL 2KNIA 3IJEB 1ATEA 1U67A 2XBXL 4NGAL 2BOHA 1P0SL 1IQEL 4Y79B 1DVAL 4NG9L 2BMGA 1ATAA 1HRFA 1F0SB 2W26B 5IKQA 4BTTA 3LC5B 4COXA 3HPTA 1YGCL 1IVOC 1YUFA 3KRKA 1UZJA 1I0UA 5FDQA 3N8WA 4CUDA 1B9WA 2P28B 2BO2A 3LTFB 3N8XA 1K36A 2F9BL 4OTJA 3LAQA 4MMZB 2FZZL 2W2OE 2P95L 2W86A 3SOVA 3CA7A 3HO3A 3TK6B 2W2PE 2J2UB 3V65B 5L30L 1IGXA 2NPRA 3HO4A 2WZPP 4JZDL 1IQJL 1IOXA 3GCWE 1YUGA 5F19A 2WFXB 1M1XB 2M74A 3DEMA 4MMXB 6COXA 1N7DA 1JBUL 3NTBA 2CJIB 3ZYGA 4CUEA 5JB8E 4RS0A 1FE2A 3FFGL 4TGFA 1N1IA 3U7UG 4JZEL 1F7EA 3M36L 1APQA 1UZPA 1IGZA 2BOUA 2H9EL 4ZHAB 1HCGB 1FSBA 2WG4B 4RRXA 1W8BL 4M10A 2XBVL 4BXWA 1NFWB 3TK5B 1EMOA 1G2MB 2P3FN 1NPEB 1APOA 5JBAE 2TGFA 4OTYA 2PHBB 1HT5A 1YUKB 1JL9A 1NFUB 4O02B 4AQTA 1UZQA 3CFWA 3RR3A 4BTIA 4C16A 1FAXL 3HS5A 3LN1A 1LPGA 3KL6B 5JBBE 3FBYA 2WPKE 1YO8A 1IQNL 3IITB 4BXSA 3MQEA 4BDWA 4X8SL 2EI7B 5I46L 1KLOA 5E8DA 2VVVL 1CVWL 3SOBB 2WFTA 1URKA 1RFNB 1FAKL 1EAIC 1LPKA 2VVCK 2Y5HL 2RA0L 2XC4L 3HS7A 3C9AC 4LMFA 3TZIA 3TH3L 4YT6L 1JV2B 4X8UL 4G1MB 4Y7BB 2J34B 4YZUB 2D1JB 5JW1A 1EBVA 2FLGA 4Z6AL 2G00L 1IQGL 1DDXA 2I9BA 2Q1JB 4FM5A 3SOQA 2WYJB 2BOKL 3Q3KB 2ADXA 1COUA 1ATDA 3ASIA 3N8ZA 1XDTR 1G1SA 2KL7A 2J38B 1NQLB 1EZQB 1NZIA 1DQBA 4E1GA 3NTGA 5EGMB 1DIYA 1KSNB 2VVUL 2DDUA 1FJSL 2W2ME 1G2LB 2VJ3A 4X8VL 1EPIA 2J4IB 4BDXA 1HREA 3SW2A 1TPGA 4D0EA 1A3PA 1IJQA 1EPHA 1WHFA 1SZBA 3CS7L 5CKNA 2W2NE 4M11A 2EI6B 3LTGD 4ZXYL 3H5CB 4PH9A 1EPJA 1G1TA 4Z0KB 4RRWA 3MDLA 3KQDL 2P3UA 3FCSB 1LMMA 1EQHA 3KQBL 1L5GB 2P94L 2P16L 2WPJE 2Y38A 2BQ7A 3V64C 2XC5L 1HX2A 3GISX 3ELAL 2K2SB 2GD4A 1TLEA 2W2QE 2VWMK 1WHEA 1BF9A 1EMNA 3CENL 3ENSA 1PRHA 2WPIE 2P93L 3PGHA 1CVUA 2OYUP 1X7AL 4BTUA 3TGFA 2FD6A 1CCVA 3NJPC 4Y71B 4D0FA 2P26A 3M37L 4YT7L 4LORA 1J9CL 1XFEA 5CISA 3HS6A 1XKBA 2WPHE 1QFKL 1O5DL 4Y7AB 1HAFA 2BOXA 2B7DL 3LC3B 1TOZA 1HJ7A 2VWLL 2XBWL 1F7MA 3QMOA 1NFYB 2YGOA 4Y6DB 4XLWA 1KIGL 1PXXA 2UWPB 2Y5FL 5KIRA 1IOEL 1MQ5L 3LIWB 4JYUL 1LPZA 1P9JA 3S6XA 1F0RB 1CCFA 3QCWA 1IQIL 1KLJL 1K37A 3ZYJB 2VWOL 4ZH8B 2K2TA 3OLUA 2P3FL 5IKTA 4ZXXL 2BQ6A 1HT8A 2BQWA 2UWOB 5L2ZL 1IQLL 1IQHL 2W3KB 5F1AA 2FLRL 1CQEA 2WPLE 5K0HB 1LQDA 2RNLA 5CKMA 2EI8B 4Y76B 4XBMA 1WU1B 2YGPA 5JBCE 2Y7XB 1KLIL 4MMYB 1G1RA 5JB9E 3TBDA 1PGEA 1Q4GA 5IKVA 1IP0A 4RRZA 1FFMA 4O1ZA 1DX5I 2J94B 1IQFL 3N8YB 1PTHA 1Z6CA 2FLBL 2JKHL 2YGQA 2WPME 2PUQL 2VWNL 5L2YL 3U73A 3EGFA 5COXA 3KQCL 3F1SB 3OLTA 4NA9L 1FF7A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1NT0 A;  4RRY A;  2MGR A;  3LN0 A;  1Z6E L;  3QH0 A;  4XL1 A;  2BZ6 L;  1MOX C;  2KV4 A;  2VH6 B;  1EPG A;  1MQ6 L;  1U8C B;  2RHP A;  4D90 A;  2W3I B;  4CUF A;  3KQE L;  4ZAE B;  1XKA L;  2KB9 A;  1OB1 C;  2J95 B;  3KCG L;  3F6U L;  3N8V A;  3BPS E;  3BT1 A;  3N8W B;  3P5B L;  5CKQ A;  3POY A;  1IQM L;  3R05 A;  1UZK A;  2UWL B;  2AYL A;  3Q7D A;  4JZF L;  1NFX B;  1HZ8 A;  1LMJ A;  2OYE P;  4ISH L;  1G1Q A;  2Y7Z B;  2PR3 B;  2P3T A;  2I9A A;  3K9X A;  1L3Y A;  1W7X L;  3KK6 A;  1EGF A;  3BT2 A;  3NT1 A;  1ZAQ A;  1AUT L;  1C5M F;  5KN5 C;  4CSY A;  2MGP A;  1CX2 A;  5JVZ A;  4JYV L;  1IQK L;  2XC0 L;  3HO5 A;  2MHP A;  2Y5G L;  3ZYI B;  2WG3 C;  1ATB A;  3N8Y A;  5JVY A;  1V3X B;  2Y81 B;  3GCX E;  2XBY L;  1HAE A;  2Y80 B;  2Y82 B;  1CEJ A;  4A7I A;  1ADX A;  5IKR A;  2WYG B;  4X8T L;  4ISI L;  1EQG A;  1GK5 A;  4RUT A;  4Z0L A;  2VH0 B;  1PFX L;  3IJE B;  1ATE A;  1U67 A;  2XBX L;  4NGA L;  2BOH A;  1P0S L;  1IQE L;  4Y79 B;  1DVA L;  4NG9 L;  2BMG A;  1ATA A;  1HRF A;  1F0S B;  2W26 B;  5IKQ A;  4BTT A;  3LC5 B;  4COX A;  3HPT A;  1YGC L;  1IVO C;  1YUF A;  3KRK A;  1UZJ A;  1I0U A;  5FDQ A;  3N8W A;  4CUD A;  1B9W A;  2P28 B;  2BO2 A;  3LTF B;  3N8X A;  1K36 A;  2F9B L;  4OTJ A;  3LAQ A;  4MMZ B;  2FZZ L;  2W2O E;  2P95 L;  2W86 A;  3SOV A;  3CA7 A;  3HO3 A;  3TK6 B;  2W2P E;  2J2U B;  3V65 B;  5L30 L;  1IGX A;  2NPR A;  3HO4 A;  4JZD L;  1IQJ L;  1IOX A;  3GCW E;  1YUG A;  5F19 A;  2WFX B;  1M1X B;  2M74 A;  3DEM A;  4MMX B;  6COX A;  1N7D A;  1JBU L;  3NTB A;  2CJI B;  3ZYG A;  4CUE A;  5JB8 E;  4RS0 A;  1FE2 A;  3FFG L;  4TGF A;  1N1I A;  3U7U G;  4JZE L;  1F7E A;  3M36 L;  1APQ A;  1UZP A;  1IGZ A;  2BOU A;  2H9E L;  4ZHA B;  1HCG B;  1FSB A;  2WG4 B;  4RRX A;  1W8B L;  4M10 A;  2XBV L;  4BXW A;  1NFW B;  3TK5 B;  1EMO A;  1G2M B;  2P3F N;  1NPE B;  1APO A;  5JBA E;  2TGF A;  4OTY A;  2PHB B;  1HT5 A;  1YUK B;  1JL9 A;  1NFU B;  4O02 B;  4AQT A;  1UZQ A;  3CFW A;  3RR3 A;  4BTI A;  4C16 A;  1FAX L;  3HS5 A;  3LN1 A;  1LPG A;  3KL6 B;  5JBB E;  3FBY A;  2WPK E;  1YO8 A;  1IQN L;  3IIT B;  4BXS A;  3MQE A;  4BDW A;  4X8S L;  2EI7 B;  5I46 L;  1KLO A;  5E8D A;  2VVV L;  1CVW L;  3SOB B;  2WFT A;  1URK A;  1RFN B;  1FAK L;  1EAI C;  1LPK A;  2VVC K;  2Y5H L;  2RA0 L;  2XC4 L;  3HS7 A;  3C9A C;  4LMF A;  3TZI A;  3TH3 L;  4YT6 L;  1JV2 B;  4X8U L;  4G1M B;  4Y7B B;  2J34 B;  4YZU B;  2D1J B;  5JW1 A;  1EBV A;  2FLG A;  4Z6A L;  2G00 L;  1IQG L;  1DDX A;  2I9B A;  2Q1J B;  4FM5 A;  3SOQ A;  2WYJ B;  2BOK L;  3Q3K B;  2ADX A;  1COU A;  1ATD A;  3ASI A;  3N8Z A;  1XDT R;  1G1S A;  2KL7 A;  2J38 B;  1NQL B;  1EZQ B;  1NZI A;  1DQB A;  4E1G A;  3NTG A;  5EGM B;  1DIY A;  1KSN B;  2VVU L;  2DDU A;  1FJS L;  2W2M E;  1G2L B;  2VJ3 A;  4X8V L;  1EPI A;  2J4I B;  4BDX A;  1HRE A;  3SW2 A;  1TPG A;  4D0E A;  1A3P A;  1IJQ A;  1EPH A;  1WHF A;  1SZB A;  3CS7 L;  5CKN A;  2W2N E;  4M11 A;  2EI6 B;  3LTG D;  4ZXY L;  3H5C B;  4PH9 A;  1EPJ A;  1G1T A;  4Z0K B;  4RRW A;  3MDL A;  3KQD L;  2P3U A;  3FCS B;  1EQH A;  3KQB L;  1L5G B;  2P94 L;  2P16 L;  2WPJ E;  2Y38 A;  2BQ7 A;  3V64 C;  2XC5 L;  1HX2 A;  3GIS X;  3ELA L;  2K2S B;  2GD4 A;  1TLE A;  2W2Q E;  2VWM K;  1WHE A;  1BF9 A;  1EMN A;  3CEN L;  3ENS A;  1PRH A;  2WPI E;  2P93 L;  3PGH A;  1CVU A;  2OYU P;  1X7A L;  4BTU A;  3TGF A;  2FD6 A;  1CCV A;  3NJP C;  4Y71 B;  4D0F A;  2P26 A;  3M37 L;  4YT7 L;  4LOR A;  1J9C L;  1XFE A;  5CIS A;  3HS6 A;  1XKB A;  2WPH E;  1QFK L;  1O5D L;  4Y7A B;  1HAF A;  2BOX A;  2B7D L;  3LC3 B;  1TOZ A;  1HJ7 A;  2VWL L;  2XBW L;  1F7M A;  3QMO A;  1NFY B;  2YGO A;  4Y6D B;  4XLW A;  1KIG L;  1PXX A;  2UWP B;  2Y5F L;  5KIR A;  1IOE L;  1MQ5 L;  3LIW B;  4JYU L;  1LPZ A;  1P9J A;  1F0R B;  1CCF A;  3QCW A;  1IQI L;  1KLJ L;  1K37 A;  3ZYJ B;  2VWO L;  4ZH8 B;  2K2T A;  3OLU A;  2P3F L;  5IKT A;  4ZXX L;  2BQ6 A;  1HT8 A;  2BQW A;  2UWO B;  5L2Z L;  1IQL L;  1IQH L;  2W3K B;  5F1A A;  2FLR L;  1CQE A;  2WPL E;  5K0H B;  1LQD A;  2RNL A;  5CKM A;  2EI8 B;  4Y76 B;  4XBM A;  1WU1 B;  2YGP A;  5JBC E;  2Y7X B;  1KLI L;  4MMY B;  1G1R A;  5JB9 E;  3TBD A;  1PGE A;  1Q4G A;  5IKV A;  1IP0 A;  4RRZ A;  1FFM A;  4O1Z A;  1DX5 I;  2J94 B;  1IQF L;  3N8Y B;  1PTH A;  1Z6C A;  2FLB L;  2JKH L;  2WPM E;  2PUQ L;  2VWN L;  5L2Y L;  3U73 A;  3EGF A;  5COX A;  3KQC L;  3F1S B;  3OLT A;  4NA9 L;  1FF7 A; 
#chains in the Genus database with same CATH topology
 1NT0 A;  4RRY A;  2MGR A;  3LN0 A;  1Z6E L;  3QH0 A;  4XL1 A;  2BZ6 L;  1MOX C;  2KV4 A;  2VH6 B;  1EPG A;  1MQ6 L;  1U8C B;  2RHP A;  4D90 A;  2W3I B;  4CUF A;  3KQE L;  4ZAE B;  1XKA L;  2KB9 A;  1OB1 C;  2J95 B;  3KCG L;  3F6U L;  3N8V A;  3BPS E;  3BT1 A;  4A94 C;  3N8W B;  3P5B L;  5CKQ A;  3POY A;  1IQM L;  3R05 A;  1UZK A;  2UWL B;  2AYL A;  3Q7D A;  4JZF L;  1NFX B;  1HZ8 A;  1LMJ A;  2OYE P;  4ISH L;  1G1Q A;  2Y7Z B;  2PR3 B;  2P3T A;  2I9A A;  3K9X A;  1L3Y A;  1W7X L;  3KK6 A;  1EGF A;  3BT2 A;  3NT1 A;  1ZAQ A;  1AUT L;  1C5M F;  5KN5 C;  4CSY A;  2MGP A;  1CX2 A;  5JVZ A;  4JYV L;  1IQK L;  2XC0 L;  3HO5 A;  2MHP A;  2H9E C;  2Y5G L;  3ZYI B;  2WG3 C;  1ATB A;  3N8Y A;  5JVY A;  1V3X B;  2Y81 B;  3GCX E;  2XBY L;  1HAE A;  2Y80 B;  2Y82 B;  1CEJ A;  4A7I A;  1ADX A;  5IKR A;  2WYG B;  4X8T L;  4ISI L;  1EQG A;  1GK5 A;  4RUT A;  4Z0L A;  2VH0 B;  1QIU A;  2HOX A;  1PFX L;  2KNI A;  3IJE B;  1ATE A;  1U67 A;  2XBX L;  4NGA L;  2BOH A;  1P0S L;  1IQE L;  4Y79 B;  1DVA L;  4NG9 L;  2BMG A;  1ATA A;  1HRF A;  1F0S B;  2W26 B;  5IKQ A;  4BTT A;  3LC5 B;  4COX A;  3HPT A;  1YGC L;  1IVO C;  1YUF A;  3KRK A;  1UZJ A;  1I0U A;  5FDQ A;  3N8W A;  4CUD A;  1B9W A;  2P28 B;  2BO2 A;  3LTF B;  3N8X A;  1K36 A;  2F9B L;  4OTJ A;  3LAQ A;  4MMZ B;  2FZZ L;  2W2O E;  2P95 L;  2W86 A;  3SOV A;  3CA7 A;  3HO3 A;  3TK6 B;  2W2P E;  2J2U B;  3V65 B;  5L30 L;  1IGX A;  2NPR A;  3HO4 A;  2WZP P;  4JZD L;  1IQJ L;  1IOX A;  3GCW E;  1YUG A;  5F19 A;  2WFX B;  1M1X B;  2M74 A;  3DEM A;  4MMX B;  6COX A;  1KKE A;  1N7D A;  1JBU L;  3NTB A;  2CJI B;  3ZYG A;  4CUE A;  5JB8 E;  4RS0 A;  1FE2 A;  3FFG L;  4TGF A;  1N1I A;  3U7U G;  4JZE L;  1F7E A;  3M36 L;  1APQ A;  1UZP A;  1IGZ A;  2BOU A;  2H9E L;  4ZHA B;  1HCG B;  1FSB A;  2WG4 B;  2BSF A;  4RRX A;  1W8B L;  4M10 A;  2XBV L;  4BXW A;  1NFW B;  3TK5 B;  1EMO A;  1G2M B;  2P3F N;  1NPE B;  1APO A;  5JBA E;  2TGF A;  4OTY A;  2PHB B;  1HT5 A;  1V1I A;  1YUK B;  1JL9 A;  1NFU B;  4O02 B;  4AQT A;  1UZQ A;  3CFW A;  3RR3 A;  4BTI A;  4C16 A;  1FAX L;  3HS5 A;  3LN1 A;  1LPG A;  3KL6 B;  5JBB E;  3FBY A;  2WPK E;  1YO8 A;  1IQN L;  2VRS A;  3IIT B;  4BXS A;  3MQE A;  4BDW A;  4X8S L;  2EI7 B;  5I46 L;  1KLO A;  5E8D A;  2VVV L;  1CVW L;  3SOB B;  2WFT A;  1URK A;  1RFN B;  1FAK L;  1EAI C;  1LPK A;  2VVC K;  2Y5H L;  2RA0 L;  4GU4 A;  2XC4 L;  3HS7 A;  3C9A C;  4LMF A;  3TZI A;  3TH3 L;  4YT6 L;  1JV2 B;  4X8U L;  4G1M B;  4Y7B B;  2J34 B;  4YZU B;  2D1J B;  5JW1 A;  1EBV A;  2FLG A;  4Z6A L;  2G00 L;  1IQG L;  1DDX A;  2I9B A;  2Q1J B;  4FM5 A;  3SOQ A;  2WYJ B;  2BOK L;  3Q3K B;  2ADX A;  1COU A;  1ATD A;  3ASI A;  3N8Z A;  1XDT R;  1G1S A;  2KL7 A;  2J38 B;  1NQL B;  1EZQ B;  1NZI A;  1DQB A;  4E1G A;  3NTG A;  5EGM B;  1DIY A;  1KSN B;  2VVU L;  2DDU A;  1LK9 A;  1FJS L;  2W2M E;  1G2L B;  2VJ3 A;  4X8V L;  1EPI A;  2J4I B;  4BDX A;  1HRE A;  3SW2 A;  1TPG A;  4D0E A;  1A3P A;  1IJQ A;  1EPH A;  1WHF A;  1SZB A;  3CS7 L;  5CKN A;  1V1H A;  2W2N E;  4M11 A;  2EI6 B;  2HOR A;  3LTG D;  4ZXY L;  3H5C B;  4PH9 A;  4GU3 A;  1EPJ A;  1G1T A;  4Z0K B;  4RRW A;  3MDL A;  3KQD L;  2P3U A;  3FCS B;  1LMM A;  1EQH A;  3KQB L;  1L5G B;  2P94 L;  2P16 L;  2BT8 A;  2WPJ E;  2Y38 A;  2BQ7 A;  3V64 C;  2XC5 L;  1HX2 A;  3GIS X;  3ELA L;  2K2S B;  2GD4 A;  1TLE A;  2W2Q E;  2VWM K;  1WHE A;  1BF9 A;  1EMN A;  3CEN L;  3ENS A;  1PRH A;  2WPI E;  2P93 L;  3PGH A;  1CVU A;  2OYU P;  1X7A L;  4BTU A;  3TGF A;  2FD6 A;  1CCV A;  3NJP C;  4Y71 B;  4D0F A;  2P26 A;  3M37 L;  4YT7 L;  4LOR A;  1J9C L;  1XFE A;  5CIS A;  3HS6 A;  1XKB A;  2WPH E;  1QFK L;  1O5D L;  4Y7A B;  1HAF A;  2JJL A;  2BOX A;  2B7D L;  3LC3 B;  1TOZ A;  1HJ7 A;  2VWL L;  2XBW L;  1F7M A;  3QMO A;  1NFY B;  2YGO A;  4Y6D B;  4XLW A;  1KIG L;  1PXX A;  2UWP B;  2Y5F L;  5KIR A;  1IOE L;  1MQ5 L;  3LIW B;  4JYU L;  1LPZ A;  1P9J A;  3S6X A;  1F0R B;  1CCF A;  3QCW A;  1IQI L;  1KLJ L;  1K37 A;  3ZYJ B;  2VWO L;  4ZH8 B;  2K2T A;  3OLU A;  2P3F L;  5IKT A;  4ZXX L;  2BQ6 A;  1HT8 A;  2BQW A;  2UWO B;  2BT7 A;  5L2Z L;  1IQL L;  1IQH L;  2W3K B;  5F1A A;  2FLR L;  1CQE A;  2WPL E;  5K0H B;  1LQD A;  2RNL A;  5CKM A;  2EI8 B;  4Y76 B;  4XBM A;  1WU1 B;  2YGP A;  5JBC E;  2Y7X B;  1KLI L;  4MMY B;  1G1R A;  5JB9 E;  3TBD A;  1PGE A;  1Q4G A;  5IKV A;  1IP0 A;  4RRZ A;  1FFM A;  4O1Z A;  1DX5 I;  2J94 B;  1IQF L;  3N8Y B;  1PTH A;  1Z6C A;  2FLB L;  2JKH L;  2YGQ A;  2WPM E;  2PUQ L;  2VWN L;  5L2Y L;  3U73 A;  3EGF A;  5COX A;  3KQC L;  3F1S B;  3OLT A;  4NA9 L;  1FF7 A; 
#chains in the Genus database with same CATH homology
 1NT0 A;  4RRY A;  2MGR A;  3LN0 A;  1Z6E L;  3QH0 A;  4XL1 A;  2BZ6 L;  1MOX C;  2KV4 A;  2VH6 B;  1EPG A;  1MQ6 L;  1U8C B;  2RHP A;  4D90 A;  2W3I B;  4CUF A;  3KQE L;  4ZAE B;  1XKA L;  2KB9 A;  1OB1 C;  2J95 B;  3KCG L;  3F6U L;  3N8V A;  3BPS E;  3BT1 A;  4A94 C;  3N8W B;  3P5B L;  5CKQ A;  3POY A;  1IQM L;  3R05 A;  1UZK A;  2UWL B;  2AYL A;  3Q7D A;  4JZF L;  1NFX B;  1HZ8 A;  1LMJ A;  2OYE P;  4ISH L;  1G1Q A;  2Y7Z B;  2PR3 B;  2P3T A;  2I9A A;  3K9X A;  1L3Y A;  1W7X L;  3KK6 A;  1EGF A;  3BT2 A;  3NT1 A;  1ZAQ A;  1AUT L;  1C5M F;  5KN5 C;  4CSY A;  2MGP A;  1CX2 A;  5JVZ A;  4JYV L;  1IQK L;  2XC0 L;  3HO5 A;  2MHP A;  2H9E C;  2Y5G L;  3ZYI B;  2WG3 C;  1ATB A;  3N8Y A;  5JVY A;  1V3X B;  2Y81 B;  3GCX E;  2XBY L;  1HAE A;  2Y80 B;  2Y82 B;  1CEJ A;  4A7I A;  1ADX A;  5IKR A;  2WYG B;  4X8T L;  4ISI L;  1EQG A;  1GK5 A;  4RUT A;  4Z0L A;  2VH0 B;  1PFX L;  2KNI A;  3IJE B;  1ATE A;  1U67 A;  2XBX L;  4NGA L;  2BOH A;  1P0S L;  1IQE L;  4Y79 B;  1DVA L;  4NG9 L;  2BMG A;  1ATA A;  1HRF A;  1F0S B;  2W26 B;  5IKQ A;  4BTT A;  3LC5 B;  4COX A;  3HPT A;  1YGC L;  1IVO C;  1YUF A;  3KRK A;  1UZJ A;  1I0U A;  5FDQ A;  3N8W A;  4CUD A;  1B9W A;  2P28 B;  2BO2 A;  3LTF B;  3N8X A;  1K36 A;  2F9B L;  4OTJ A;  3LAQ A;  4MMZ B;  2FZZ L;  2W2O E;  2P95 L;  2W86 A;  3SOV A;  3CA7 A;  3HO3 A;  3TK6 B;  2W2P E;  2J2U B;  3V65 B;  5L30 L;  1IGX A;  2NPR A;  3HO4 A;  2WZP P;  4JZD L;  1IQJ L;  1IOX A;  3GCW E;  1YUG A;  5F19 A;  2WFX B;  1M1X B;  2M74 A;  3DEM A;  4MMX B;  6COX A;  1N7D A;  1JBU L;  3NTB A;  2CJI B;  3ZYG A;  4CUE A;  5JB8 E;  4RS0 A;  1FE2 A;  3FFG L;  4TGF A;  1N1I A;  3U7U G;  4JZE L;  1F7E A;  3M36 L;  1APQ A;  1UZP A;  1IGZ A;  2BOU A;  2H9E L;  4ZHA B;  1HCG B;  1FSB A;  2WG4 B;  4RRX A;  1W8B L;  4M10 A;  2XBV L;  4BXW A;  1NFW B;  3TK5 B;  1EMO A;  1G2M B;  2P3F N;  1NPE B;  1APO A;  5JBA E;  2TGF A;  4OTY A;  2PHB B;  1HT5 A;  1YUK B;  1JL9 A;  1NFU B;  4O02 B;  4AQT A;  1UZQ A;  3CFW A;  3RR3 A;  4BTI A;  4C16 A;  1FAX L;  3HS5 A;  3LN1 A;  1LPG A;  3KL6 B;  5JBB E;  3FBY A;  2WPK E;  1YO8 A;  1IQN L;  3IIT B;  4BXS A;  3MQE A;  4BDW A;  4X8S L;  2EI7 B;  5I46 L;  1KLO A;  5E8D A;  2VVV L;  1CVW L;  3SOB B;  2WFT A;  1URK A;  1RFN B;  1FAK L;  1EAI C;  1LPK A;  2VVC K;  2Y5H L;  2RA0 L;  2XC4 L;  3HS7 A;  3C9A C;  4LMF A;  3TZI A;  3TH3 L;  4YT6 L;  1JV2 B;  4X8U L;  4G1M B;  4Y7B B;  2J34 B;  4YZU B;  2D1J B;  5JW1 A;  1EBV A;  2FLG A;  4Z6A L;  2G00 L;  1IQG L;  1DDX A;  2I9B A;  2Q1J B;  4FM5 A;  3SOQ A;  2WYJ B;  2BOK L;  3Q3K B;  2ADX A;  1COU A;  1ATD A;  3ASI A;  3N8Z A;  1XDT R;  1G1S A;  2KL7 A;  2J38 B;  1NQL B;  1EZQ B;  1NZI A;  1DQB A;  4E1G A;  3NTG A;  5EGM B;  1DIY A;  1KSN B;  2VVU L;  2DDU A;  1FJS L;  2W2M E;  1G2L B;  2VJ3 A;  4X8V L;  1EPI A;  2J4I B;  4BDX A;  1HRE A;  3SW2 A;  1TPG A;  4D0E A;  1A3P A;  1IJQ A;  1EPH A;  1WHF A;  1SZB A;  3CS7 L;  5CKN A;  2W2N E;  4M11 A;  2EI6 B;  3LTG D;  4ZXY L;  3H5C B;  4PH9 A;  1EPJ A;  1G1T A;  4Z0K B;  4RRW A;  3MDL A;  3KQD L;  2P3U A;  3FCS B;  1LMM A;  1EQH A;  3KQB L;  1L5G B;  2P94 L;  2P16 L;  2WPJ E;  2Y38 A;  2BQ7 A;  3V64 C;  2XC5 L;  1HX2 A;  3GIS X;  3ELA L;  2K2S B;  2GD4 A;  1TLE A;  2W2Q E;  2VWM K;  1WHE A;  1BF9 A;  1EMN A;  3CEN L;  3ENS A;  1PRH A;  2WPI E;  2P93 L;  3PGH A;  1CVU A;  2OYU P;  1X7A L;  4BTU A;  3TGF A;  2FD6 A;  1CCV A;  3NJP C;  4Y71 B;  4D0F A;  2P26 A;  3M37 L;  4YT7 L;  4LOR A;  1J9C L;  1XFE A;  5CIS A;  3HS6 A;  1XKB A;  2WPH E;  1QFK L;  1O5D L;  4Y7A B;  1HAF A;  2BOX A;  2B7D L;  3LC3 B;  1TOZ A;  1HJ7 A;  2VWL L;  2XBW L;  1F7M A;  3QMO A;  1NFY B;  2YGO A;  4Y6D B;  4XLW A;  1KIG L;  1PXX A;  2UWP B;  2Y5F L;  5KIR A;  1IOE L;  1MQ5 L;  3LIW B;  4JYU L;  1LPZ A;  1P9J A;  3S6X A;  1F0R B;  1CCF A;  3QCW A;  1IQI L;  1KLJ L;  1K37 A;  3ZYJ B;  2VWO L;  4ZH8 B;  2K2T A;  3OLU A;  2P3F L;  5IKT A;  4ZXX L;  2BQ6 A;  1HT8 A;  2BQW A;  2UWO B;  5L2Z L;  1IQL L;  1IQH L;  2W3K B;  5F1A A;  2FLR L;  1CQE A;  2WPL E;  5K0H B;  1LQD A;  2RNL A;  5CKM A;  2EI8 B;  4Y76 B;  4XBM A;  1WU1 B;  2YGP A;  5JBC E;  2Y7X B;  1KLI L;  4MMY B;  1G1R A;  5JB9 E;  3TBD A;  1PGE A;  1Q4G A;  5IKV A;  1IP0 A;  4RRZ A;  1FFM A;  4O1Z A;  1DX5 I;  2J94 B;  1IQF L;  3N8Y B;  1PTH A;  1Z6C A;  2FLB L;  2JKH L;  2YGQ A;  2WPM E;  2PUQ L;  2VWN L;  5L2Y L;  3U73 A;  3EGF A;  5COX A;  3KQC L;  3F1S B;  3OLT A;  4NA9 L;  1FF7 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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