4X8TL

Factor viia in complex with the inhibitor 7-chloro-3,4-dihydroisoquinolin-1(2h)-one
Total Genus 12
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
12
sequence length
55
structure length
55
Chain Sequence
ICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILEKR
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Discovery of Novel P1 Groups for Coagulation Factor VIIa Inhibition Using Fragment-Based Screening.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Homo sapiens
molecule keywords Factor VIIa (Heavy Chain)
total genus 12
structure length 55
sequence length 55
ec nomenclature ec 3.4.21.21: Coagulation factor VIIa.
pdb deposition date 2014-12-10
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.25.10 Mainly Beta Ribbon Laminin Laminin 4x8tL00
1CVWL 3PGHA 1L5GB 1PGEA 3LC5B 2FLRL 1KLIL 1CCVA 1QFKL 3QMOA 2M74A 1UZKA 2W2PE 1NT0A 3CS7L 2W2OE 4D90A 1IQHL 3HO4A 1HRFA 2YGOA 5JVZA 3KK6A 4JYUL 1NFYB 2D1JB 5COXA 4ISIL 6COXA 5KIRA 3ZYIB 1CEJA 1UZPA 1ATBA 4RUTA 2B7DL 2XBXL 1UZJA 3FFGL 1WU1B 4ISHL 5I46L 3N8VA 3LTGD 1G1TA 5CISA 1C5MF 2YGPA 2VVCK 2WG3C 3BT1A 5EGMB 1YO8A 5JB8E 4NGAL 1APOA 3FBYA 4ZXYL 1HCGB 5CKMA 1O5DL 4BTIA 2J38B 2J4IB 2RNLA 3IJEB 4Y71B 2VH6B 2Y38A 1IOXA 2K2TA 4Z0KB 1WHFA 2W2ME 1LPKA 3ENSA 3TBDA 3OLUA 4X8UL 3H5CB 1HJ7A 2Y7XB 1P0SL 2H9EL 4M10A 4JYVL 1EPIA 4O02B 1IQKL 1EMOA 2Q1JB 1FE2A 1NFXB 3GISX 3POYA 4BTUA 4XL1A 3NJPC 1IQJL 3CENL 2P3UA 4E1GA 2WYGB 1IGXA 3FCSB 2W26B 3Q3KB 1JBUL 4MMYB 3N8WB 1DDXA 5L30L 1IQML 1EGFA 1URKA 1DVAL 2Y5GL 4RS0A 4BDWA 2Y7ZB 3GCWE 1DIYA 1JV2B 3LTFB 4YZUB 1ADXA 5JW1A 1YGCL 1KLOA 2P16L 3TK5B 3CFWA 1K37A 1IQNL 2Y5HL 4CUDA 2Y82B 1YUKB 2UWOB 1EPGA 1G1RA 3MQEA 1LPZA 4X8TL 5IKTA 1GK5A 1G2MB 2G00L 3MDLA 2XC5L 4Y7AB 2XBYL 1EQGA 1Z6CA 3ZYJB 5K0HB 3K9XA 3QCWA 5F1AA 2UWPB 1KIGL 2RA0L 1ZAQA 3SOQA 4RRZA 3ELAL 3N8YA 1NFUB 4ZHAB 5JBBE 5JVYA 5L2ZL 4Y7BB 4C16A 5IKVA 5F19A 1HZ8A 1AUTL 1XKAL 2RHPA 4ZH8B 2XC0L 4YT7L 1YUFA 2WPKE 1IJQA 2WFXB 2W3IB 2PUQL 2WPJE 2FD6A 1IQIL 2Y80B 5E8DA 1IQGL 1G2LB 2J2UB 2OYEP 1F7EA 3N8ZA 4JZFL 4FM5A 3QH0A 1FFMA 2XBVL 3HO5A 1TOZA 1EPJA 3IITB 2P3FL 2WPHE 4BDXA 3TGFA 4TGFA 1U67A 3N8YB 1NZIA 2FLBL 4X8VL 1XFEA 1HT5A 2I9BA 2FZZL 3NT1A 1HT8A 2PR3B 1JL9A 3F1SB 5JBCE 3SOVA 2VWOL 2BOHA 3NTBA 4JZDL 1FAKL 1ATDA 5CKQA 3TZIA 3Q7DA 2KB9A 1COUA 1EAIC 3BT2A 4BXWA 5CKNA 1OB1C 1EPHA 2EI6B 1V3XB 1FF7A 1F7MA 1PRHA 2WYJB 5JB9E 4YT6L 2VVVL 3KRKA 3LN1A 3GCXE 2K2SB 4XLWA 1FJSL 2BQ6A 1KLJL 2F9BL 4M11A 3SW2A 1MOXC 4CSYA 2VH0B 2DDUA 1CVUA 4Z0LA 1TLEA 3ASIA 2BO2A 3KQEL 1A3PA 1X7AL 3M37L 1G1SA 3BPSE 1K36A 2W86A 1LMJA 1ATEA 3U7UG 1SZBA 1HAFA 4JZEL 3LN0A 2BZ6L 3ZYGA 5IKQA 1W8BL 3HS6A 1IQLL 2KV4A 1IGZA 5IKRA 3V64C 3LIWB 1FAXL 2OYUP 3N8XA 1G1QA 1WHEA 4OTJA 1KSNB 1XDTR 4MMZB 1XKBA 3R05A 1IQEL 1IVOC 3DEMA 4Z6AL 1LPGA 4AQTA 1J9CL 1IQFL 3TH3L 2JKHL 1P9JA 4NG9L 1N1IA 3HS7A 1F0SB 5L2YL 1NPEB 2VWMK 3F6UL 4Y76B 1EQHA 2FLGA 2AYLA 2MHPA 2W2NE 4ZXXL 4RRYA 3KL6B 1FSBA 1N7DA 3HO3A 1UZQA 4BTTA 2EI8B 2VVUL 2BOUA 2WFTA 1BF9A 3SOBB 4O1ZA 3KCGL 3KQCL 2J95B 2VWNL 2WPME 4BXSA 2Y81B 1DX5I 1HX2A 1EZQB 1LQDA 2WPIE 2PHBB 2J34B 1EBVA 4CUEA 4PH9A 1CX2A 4NA9L 1W7XL 1Q4GA 4RRXA 1I0UA 2BOXA 1TPGA 2KL7A 1YUGA 3M36L 1Z6EL 1MQ6L 4LMFA 1PXXA 3V65B 2XBWL 1F0RB 3N8WA 4OTYA 1RFNB 4D0FA 3KQDL 2MGRA 2BQ7A 3LAQA 2BMGA 2MGPA 3RR3A 2BOKL 1ATAA 2NPRA 3C9AC 2UWLB 4CUFA 1APQA 4XBMA 3LC3B 2P3TA 1PTHA 1MQ5L 2VWLL 2W2QE 1NQLB 2GD4A 4A7IA 1IOEL 2EI7B 4Y6DB 1HAEA 4MMXB 1L3YA 2VJ3A 5KN5C 3EGFA 3HS5A 1IP0A 3P5BL 1HREA 3NTGA 1DQBA 2P3FN 2ADXA 4ZAEB 1M1XB 2I9AA 5FDQA 2BQWA 4G1MB 1B9WA 2CJIB 2WPLE 2XC4L 4COXA 1CCFA 2P94L 2P26A 1CQEA 2Y5FL 3U73A 2J94B 4X8SL 3HPTA 2WG4B 4RRWA 2P93L 2P28B 2W3KB 4D0EA 3KQBL 1U8CB 1PFXL 1NFWB 1EMNA 4LORA 2TGFA 3TK6B 3CA7A 4Y79B 5JBAE 3OLTA 2P95L
chains in the Genus database with same CATH superfamily
1CVWL 3PGHA 1L5GB 1PGEA 3LC5B 2FLRL 1KLIL 1CCVA 1QFKL 3QMOA 2M74A 1UZKA 2W2PE 1NT0A 3CS7L 2W2OE 1KKEA 4D90A 1IQHL 3HO4A 1HRFA 2YGOA 5JVZA 3KK6A 4JYUL 1NFYB 2D1JB 5COXA 4ISIL 6COXA 5KIRA 3ZYIB 1CEJA 1UZPA 1ATBA 4RUTA 2B7DL 2XBXL 1UZJA 3FFGL 1WU1B 4ISHL 5I46L 3N8VA 3LTGD 1G1TA 5CISA 1C5MF 3S6XA 2YGPA 2VVCK 2WG3C 3BT1A 5EGMB 1YO8A 5JB8E 4NGAL 1APOA 3FBYA 2HOXA 4ZXYL 1HCGB 5CKMA 1O5DL 4BTIA 2J38B 2J4IB 2RNLA 3IJEB 2BT7A 4Y71B 2VH6B 2Y38A 1IOXA 2K2TA 4Z0KB 1WHFA 2W2ME 1LPKA 3ENSA 3TBDA 3OLUA 4X8UL 3H5CB 1HJ7A 2Y7XB 1P0SL 2H9EL 4M10A 4JYVL 1EPIA 4O02B 1IQKL 1EMOA 2Q1JB 1FE2A 1NFXB 3GISX 3POYA 4BTUA 4XL1A 3NJPC 2HORA 1IQJL 3CENL 2P3UA 4E1GA 2WYGB 1IGXA 3FCSB 2W26B 3Q3KB 4GU4A 1JBUL 4MMYB 3N8WB 1DDXA 5L30L 1IQML 1EGFA 1URKA 1DVAL 2Y5GL 4RS0A 4BDWA 2Y7ZB 3GCWE 1DIYA 2BT8A 1JV2B 3LTFB 4YZUB 1ADXA 5JW1A 1YGCL 1KLOA 2P16L 3TK5B 3CFWA 1K37A 1IQNL 2Y5HL 4CUDA 2Y82B 4GU3A 1YUKB 2UWOB 1EPGA 1G1RA 3MQEA 1LK9A 1LPZA 4X8TL 5IKTA 1GK5A 1G2MB 2G00L 3MDLA 2XC5L 4Y7AB 2XBYL 1V1IA 1EQGA 1Z6CA 3ZYJB 5K0HB 3K9XA 3QCWA 5F1AA 2UWPB 1KIGL 2RA0L 1ZAQA 3SOQA 4RRZA 3ELAL 3N8YA 1NFUB 4ZHAB 5JBBE 5JVYA 5L2ZL 4Y7BB 4C16A 5IKVA 5F19A 1HZ8A 1AUTL 1XKAL 2RHPA 4ZH8B 2XC0L 4YT7L 1YUFA 2WPKE 1QIUA 1IJQA 2WFXB 2W3IB 2PUQL 2WPJE 2FD6A 1IQIL 2Y80B 5E8DA 1IQGL 1G2LB 2J2UB 2OYEP 1F7EA 3N8ZA 4JZFL 4FM5A 3QH0A 1FFMA 2XBVL 3HO5A 1TOZA 1EPJA 3IITB 2P3FL 2WPHE 4BDXA 3TGFA 4TGFA 1U67A 3N8YB 1NZIA 2FLBL 4X8VL 1XFEA 1HT5A 2I9BA 2FZZL 3NT1A 1HT8A 2PR3B 1JL9A 3F1SB 5JBCE 1V1HA 3SOVA 2VWOL 2BOHA 3NTBA 4JZDL 1FAKL 1ATDA 5CKQA 3TZIA 3Q7DA 2KB9A 1COUA 1EAIC 3BT2A 4BXWA 5CKNA 1OB1C 1EPHA 2EI6B 1V3XB 1FF7A 1F7MA 1PRHA 2WYJB 5JB9E 4YT6L 2VVVL 3KRKA 3LN1A 3GCXE 2K2SB 4XLWA 1FJSL 2BQ6A 1KLJL 2F9BL 4M11A 3SW2A 1MOXC 4CSYA 2VH0B 2DDUA 1CVUA 4Z0LA 1TLEA 3ASIA 2BO2A 3KQEL 1A3PA 1X7AL 3M37L 2JJLA 1G1SA 3BPSE 1K36A 2W86A 1LMJA 1ATEA 3U7UG 1SZBA 1HAFA 4JZEL 3LN0A 2BZ6L 3ZYGA 5IKQA 1W8BL 3HS6A 1IQLL 2KV4A 1IGZA 5IKRA 3V64C 3LIWB 2YGQA 1FAXL 2OYUP 3N8XA 1G1QA 1WHEA 4OTJA 1KSNB 1XDTR 4MMZB 1XKBA 3R05A 1IQEL 1IVOC 3DEMA 4Z6AL 1LPGA 4AQTA 1J9CL 1IQFL 3TH3L 2JKHL 1P9JA 4NG9L 1N1IA 3HS7A 1F0SB 5L2YL 2H9EC 1NPEB 2VWMK 3F6UL 4Y76B 1EQHA 2FLGA 2AYLA 2MHPA 2W2NE 4ZXXL 4RRYA 3KL6B 1FSBA 1N7DA 3HO3A 1UZQA 4BTTA 2EI8B 2VVUL 2KNIA 2BOUA 2WFTA 1BF9A 3SOBB 4O1ZA 3KCGL 3KQCL 2J95B 2VWNL 2WPME 4BXSA 2Y81B 1DX5I 1HX2A 1EZQB 2WZPP 1LQDA 2WPIE 2PHBB 2J34B 1EBVA 4CUEA 4PH9A 1CX2A 4NA9L 1W7XL 1Q4GA 4RRXA 1I0UA 2BOXA 1TPGA 2KL7A 1YUGA 3M36L 1Z6EL 1MQ6L 4LMFA 1PXXA 3V65B 2XBWL 1F0RB 3N8WA 4OTYA 1RFNB 4D0FA 3KQDL 2MGRA 2BSFA 2BQ7A 3LAQA 2BMGA 2MGPA 3RR3A 2BOKL 1ATAA 2NPRA 3C9AC 2UWLB 4CUFA 1APQA 4XBMA 3LC3B 2P3TA 1PTHA 1MQ5L 2VWLL 2W2QE 1NQLB 2GD4A 4A7IA 1IOEL 2EI7B 4Y6DB 1HAEA 4MMXB 1L3YA 2VJ3A 5KN5C 3EGFA 3HS5A 1IP0A 3P5BL 1HREA 3NTGA 1DQBA 2P3FN 2ADXA 4ZAEB 1M1XB 2I9AA 5FDQA 2BQWA 4G1MB 1B9WA 2CJIB 2WPLE 2XC4L 4COXA 1CCFA 2P94L 2P26A 1CQEA 2Y5FL 3U73A 2J94B 4X8SL 3HPTA 2WG4B 4RRWA 4A94C 2P93L 2P28B 2W3KB 2VRSA 4D0EA 3KQBL 1U8CB 1PFXL 1NFWB 1LMMA 1EMNA 4LORA 2TGFA 3TK6B 3CA7A 4Y79B 5JBAE 3OLTA 2P95L
chains in the Genus database with same CATH topology
1CVWL 3PGHA 1L5GB 1PGEA 3LC5B 2FLRL 1KLIL 1CCVA 1QFKL 3QMOA 2M74A 1UZKA 2W2PE 1NT0A 3CS7L 2W2OE 4D90A 1IQHL 3HO4A 1HRFA 2YGOA 5JVZA 3KK6A 4JYUL 1NFYB 2D1JB 5COXA 4ISIL 6COXA 5KIRA 3ZYIB 1CEJA 1UZPA 1ATBA 4RUTA 2B7DL 2XBXL 1UZJA 3FFGL 1WU1B 4ISHL 5I46L 3N8VA 3LTGD 1G1TA 5CISA 1C5MF 3S6XA 2YGPA 2VVCK 2WG3C 3BT1A 5EGMB 1YO8A 5JB8E 4NGAL 1APOA 3FBYA 4ZXYL 1HCGB 5CKMA 1O5DL 4BTIA 2J38B 2J4IB 2RNLA 3IJEB 4Y71B 2VH6B 2Y38A 1IOXA 2K2TA 4Z0KB 1WHFA 2W2ME 1LPKA 3ENSA 3TBDA 3OLUA 4X8UL 3H5CB 1HJ7A 2Y7XB 1P0SL 2H9EL 4M10A 4JYVL 1EPIA 4O02B 1IQKL 1EMOA 2Q1JB 1FE2A 1NFXB 3GISX 3POYA 4BTUA 4XL1A 3NJPC 1IQJL 3CENL 2P3UA 4E1GA 2WYGB 1IGXA 3FCSB 2W26B 3Q3KB 1JBUL 4MMYB 3N8WB 1DDXA 5L30L 1IQML 1EGFA 1URKA 1DVAL 2Y5GL 4RS0A 4BDWA 2Y7ZB 3GCWE 1DIYA 1JV2B 3LTFB 4YZUB 1ADXA 5JW1A 1YGCL 1KLOA 2P16L 3TK5B 3CFWA 1K37A 1IQNL 2Y5HL 4CUDA 2Y82B 1YUKB 2UWOB 1EPGA 1G1RA 3MQEA 1LPZA 4X8TL 5IKTA 1GK5A 1G2MB 2G00L 3MDLA 2XC5L 4Y7AB 2XBYL 1EQGA 1Z6CA 3ZYJB 5K0HB 3K9XA 3QCWA 5F1AA 2UWPB 1KIGL 2RA0L 1ZAQA 3SOQA 4RRZA 3ELAL 3N8YA 1NFUB 4ZHAB 5JBBE 5JVYA 5L2ZL 4Y7BB 4C16A 5IKVA 5F19A 1HZ8A 1AUTL 1XKAL 2RHPA 4ZH8B 2XC0L 4YT7L 1YUFA 2WPKE 1IJQA 2WFXB 2W3IB 2PUQL 2WPJE 2FD6A 1IQIL 2Y80B 5E8DA 1IQGL 1G2LB 2J2UB 2OYEP 1F7EA 3N8ZA 4JZFL 4FM5A 3QH0A 1FFMA 2XBVL 3HO5A 1TOZA 1EPJA 3IITB 2P3FL 2WPHE 4BDXA 3TGFA 4TGFA 1U67A 3N8YB 1NZIA 2FLBL 4X8VL 1XFEA 1HT5A 2I9BA 2FZZL 3NT1A 1HT8A 2PR3B 1JL9A 3F1SB 5JBCE 3SOVA 2VWOL 2BOHA 3NTBA 4JZDL 1FAKL 1ATDA 5CKQA 3TZIA 3Q7DA 2KB9A 1COUA 1EAIC 3BT2A 4BXWA 5CKNA 1OB1C 1EPHA 2EI6B 1V3XB 1FF7A 1F7MA 1PRHA 2WYJB 5JB9E 4YT6L 2VVVL 3KRKA 3LN1A 3GCXE 2K2SB 4XLWA 1FJSL 2BQ6A 1KLJL 2F9BL 4M11A 3SW2A 1MOXC 4CSYA 2VH0B 2DDUA 1CVUA 4Z0LA 1TLEA 3ASIA 2BO2A 3KQEL 1A3PA 1X7AL 3M37L 1G1SA 3BPSE 1K36A 2W86A 1LMJA 1ATEA 3U7UG 1SZBA 1HAFA 4JZEL 3LN0A 2BZ6L 3ZYGA 5IKQA 1W8BL 3HS6A 1IQLL 2KV4A 1IGZA 5IKRA 3V64C 3LIWB 2YGQA 1FAXL 2OYUP 3N8XA 1G1QA 1WHEA 4OTJA 1KSNB 1XDTR 4MMZB 1XKBA 3R05A 1IQEL 1IVOC 3DEMA 4Z6AL 1LPGA 4AQTA 1J9CL 1IQFL 3TH3L 2JKHL 1P9JA 4NG9L 1N1IA 3HS7A 1F0SB 5L2YL 2H9EC 1NPEB 2VWMK 3F6UL 4Y76B 1EQHA 2FLGA 2AYLA 2MHPA 2W2NE 4ZXXL 4RRYA 3KL6B 1FSBA 1N7DA 3HO3A 1UZQA 4BTTA 2EI8B 2VVUL 2KNIA 2BOUA 2WFTA 1BF9A 3SOBB 4O1ZA 3KCGL 3KQCL 2J95B 2VWNL 2WPME 4BXSA 2Y81B 1DX5I 1HX2A 1EZQB 2WZPP 1LQDA 2WPIE 2PHBB 2J34B 1EBVA 4CUEA 4PH9A 1CX2A 4NA9L 1W7XL 1Q4GA 4RRXA 1I0UA 2BOXA 1TPGA 2KL7A 1YUGA 3M36L 1Z6EL 1MQ6L 4LMFA 1PXXA 3V65B 2XBWL 1F0RB 3N8WA 4OTYA 1RFNB 4D0FA 3KQDL 2MGRA 2BQ7A 3LAQA 2BMGA 2MGPA 3RR3A 2BOKL 1ATAA 2NPRA 3C9AC 2UWLB 4CUFA 1APQA 4XBMA 3LC3B 2P3TA 1PTHA 1MQ5L 2VWLL 2W2QE 1NQLB 2GD4A 4A7IA 1IOEL 2EI7B 4Y6DB 1HAEA 4MMXB 1L3YA 2VJ3A 5KN5C 3EGFA 3HS5A 1IP0A 3P5BL 1HREA 3NTGA 1DQBA 2P3FN 2ADXA 4ZAEB 1M1XB 2I9AA 5FDQA 2BQWA 4G1MB 1B9WA 2CJIB 2WPLE 2XC4L 4COXA 1CCFA 2P94L 2P26A 1CQEA 2Y5FL 3U73A 2J94B 4X8SL 3HPTA 2WG4B 4RRWA 4A94C 2P93L 2P28B 2W3KB 4D0EA 3KQBL 1U8CB 1PFXL 1NFWB 1LMMA 1EMNA 4LORA 2TGFA 3TK6B 3CA7A 4Y79B 5JBAE 3OLTA 2P95L
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1CVW L;  3PGH A;  1L5G B;  1PGE A;  3LC5 B;  2FLR L;  1KLI L;  1CCV A;  1QFK L;  3QMO A;  2M74 A;  1UZK A;  2W2P E;  1NT0 A;  3CS7 L;  2W2O E;  4D90 A;  1IQH L;  3HO4 A;  1HRF A;  2YGO A;  5JVZ A;  3KK6 A;  4JYU L;  1NFY B;  2D1J B;  5COX A;  4ISI L;  6COX A;  5KIR A;  3ZYI B;  1CEJ A;  1UZP A;  1ATB A;  4RUT A;  2B7D L;  2XBX L;  1UZJ A;  3FFG L;  1WU1 B;  4ISH L;  5I46 L;  3N8V A;  3LTG D;  1G1T A;  5CIS A;  1C5M F;  2YGP A;  2VVC K;  2WG3 C;  3BT1 A;  5EGM B;  1YO8 A;  5JB8 E;  4NGA L;  1APO A;  3FBY A;  4ZXY L;  1HCG B;  5CKM A;  1O5D L;  4BTI A;  2J38 B;  2J4I B;  2RNL A;  3IJE B;  4Y71 B;  2VH6 B;  2Y38 A;  1IOX A;  2K2T A;  4Z0K B;  1WHF A;  2W2M E;  1LPK A;  3ENS A;  3TBD A;  3OLU A;  4X8U L;  3H5C B;  1HJ7 A;  2Y7X B;  1P0S L;  2H9E L;  4M10 A;  4JYV L;  1EPI A;  4O02 B;  1IQK L;  1EMO A;  2Q1J B;  1FE2 A;  1NFX B;  3GIS X;  3POY A;  4BTU A;  4XL1 A;  3NJP C;  1IQJ L;  3CEN L;  2P3U A;  4E1G A;  2WYG B;  1IGX A;  3FCS B;  2W26 B;  3Q3K B;  1JBU L;  4MMY B;  3N8W B;  1DDX A;  5L30 L;  1IQM L;  1EGF A;  1URK A;  1DVA L;  2Y5G L;  4RS0 A;  4BDW A;  2Y7Z B;  3GCW E;  1DIY A;  1JV2 B;  3LTF B;  4YZU B;  1ADX A;  5JW1 A;  1YGC L;  1KLO A;  2P16 L;  3TK5 B;  3CFW A;  1K37 A;  1IQN L;  2Y5H L;  4CUD A;  2Y82 B;  1YUK B;  2UWO B;  1EPG A;  1G1R A;  3MQE A;  1LPZ A;  4X8T L;  5IKT A;  1GK5 A;  1G2M B;  2G00 L;  3MDL A;  2XC5 L;  4Y7A B;  2XBY L;  1EQG A;  1Z6C A;  3ZYJ B;  5K0H B;  3K9X A;  3QCW A;  5F1A A;  2UWP B;  1KIG L;  2RA0 L;  1ZAQ A;  3SOQ A;  4RRZ A;  3ELA L;  3N8Y A;  1NFU B;  4ZHA B;  5JBB E;  5JVY A;  5L2Z L;  4Y7B B;  4C16 A;  5IKV A;  5F19 A;  1HZ8 A;  1AUT L;  1XKA L;  2RHP A;  4ZH8 B;  2XC0 L;  4YT7 L;  1YUF A;  2WPK E;  1IJQ A;  2WFX B;  2W3I B;  2PUQ L;  2WPJ E;  2FD6 A;  1IQI L;  2Y80 B;  5E8D A;  1IQG L;  1G2L B;  2J2U B;  2OYE P;  1F7E A;  3N8Z A;  4JZF L;  4FM5 A;  3QH0 A;  1FFM A;  2XBV L;  3HO5 A;  1TOZ A;  1EPJ A;  3IIT B;  2P3F L;  2WPH E;  4BDX A;  3TGF A;  4TGF A;  1U67 A;  3N8Y B;  1NZI A;  2FLB L;  4X8V L;  1XFE A;  1HT5 A;  2I9B A;  2FZZ L;  3NT1 A;  1HT8 A;  2PR3 B;  1JL9 A;  3F1S B;  5JBC E;  3SOV A;  2VWO L;  2BOH A;  3NTB A;  4JZD L;  1FAK L;  1ATD A;  5CKQ A;  3TZI A;  3Q7D A;  2KB9 A;  1COU A;  1EAI C;  3BT2 A;  4BXW A;  5CKN A;  1OB1 C;  1EPH A;  2EI6 B;  1V3X B;  1FF7 A;  1F7M A;  1PRH A;  2WYJ B;  5JB9 E;  4YT6 L;  2VVV L;  3KRK A;  3LN1 A;  3GCX E;  2K2S B;  4XLW A;  1FJS L;  2BQ6 A;  1KLJ L;  2F9B L;  4M11 A;  3SW2 A;  1MOX C;  4CSY A;  2VH0 B;  2DDU A;  1CVU A;  4Z0L A;  1TLE A;  3ASI A;  2BO2 A;  3KQE L;  1A3P A;  1X7A L;  3M37 L;  1G1S A;  3BPS E;  1K36 A;  2W86 A;  1LMJ A;  1ATE A;  3U7U G;  1SZB A;  1HAF A;  4JZE L;  3LN0 A;  2BZ6 L;  3ZYG A;  5IKQ A;  1W8B L;  3HS6 A;  1IQL L;  2KV4 A;  1IGZ A;  5IKR A;  3V64 C;  3LIW B;  1FAX L;  2OYU P;  3N8X A;  1G1Q A;  1WHE A;  4OTJ A;  1KSN B;  1XDT R;  4MMZ B;  1XKB A;  3R05 A;  1IQE L;  1IVO C;  3DEM A;  4Z6A L;  1LPG A;  4AQT A;  1J9C L;  1IQF L;  3TH3 L;  2JKH L;  1P9J A;  4NG9 L;  1N1I A;  3HS7 A;  1F0S B;  5L2Y L;  1NPE B;  2VWM K;  3F6U L;  4Y76 B;  1EQH A;  2FLG A;  2AYL A;  2MHP A;  2W2N E;  4ZXX L;  4RRY A;  3KL6 B;  1FSB A;  1N7D A;  3HO3 A;  1UZQ A;  4BTT A;  2EI8 B;  2VVU L;  2BOU A;  2WFT A;  1BF9 A;  3SOB B;  4O1Z A;  3KCG L;  3KQC L;  2J95 B;  2VWN L;  2WPM E;  4BXS A;  2Y81 B;  1DX5 I;  1HX2 A;  1EZQ B;  1LQD A;  2WPI E;  2PHB B;  2J34 B;  1EBV A;  4CUE A;  4PH9 A;  1CX2 A;  4NA9 L;  1W7X L;  1Q4G A;  4RRX A;  1I0U A;  2BOX A;  1TPG A;  2KL7 A;  1YUG A;  3M36 L;  1Z6E L;  1MQ6 L;  4LMF A;  1PXX A;  3V65 B;  2XBW L;  1F0R B;  3N8W A;  4OTY A;  1RFN B;  4D0F A;  3KQD L;  2MGR A;  2BQ7 A;  3LAQ A;  2BMG A;  2MGP A;  3RR3 A;  2BOK L;  1ATA A;  2NPR A;  3C9A C;  2UWL B;  4CUF A;  1APQ A;  4XBM A;  3LC3 B;  2P3T A;  1PTH A;  1MQ5 L;  2VWL L;  2W2Q E;  1NQL B;  2GD4 A;  4A7I A;  1IOE L;  2EI7 B;  4Y6D B;  1HAE A;  4MMX B;  1L3Y A;  2VJ3 A;  5KN5 C;  3EGF A;  3HS5 A;  1IP0 A;  3P5B L;  1HRE A;  3NTG A;  1DQB A;  2P3F N;  2ADX A;  4ZAE B;  1M1X B;  2I9A A;  5FDQ A;  2BQW A;  4G1M B;  1B9W A;  2CJI B;  2WPL E;  2XC4 L;  4COX A;  1CCF A;  2P94 L;  2P26 A;  1CQE A;  2Y5F L;  3U73 A;  2J94 B;  4X8S L;  3HPT A;  2WG4 B;  4RRW A;  2P93 L;  2P28 B;  2W3K B;  4D0E A;  3KQB L;  1U8C B;  1PFX L;  1NFW B;  1EMN A;  4LOR A;  2TGF A;  3TK6 B;  3CA7 A;  4Y79 B;  5JBA E;  3OLT A;  2P95 L; 
#chains in the Genus database with same CATH topology
 1CVW L;  3PGH A;  1L5G B;  1PGE A;  3LC5 B;  2FLR L;  1KLI L;  1CCV A;  1QFK L;  3QMO A;  2M74 A;  1UZK A;  2W2P E;  1NT0 A;  3CS7 L;  2W2O E;  1KKE A;  4D90 A;  1IQH L;  3HO4 A;  1HRF A;  2YGO A;  5JVZ A;  3KK6 A;  4JYU L;  1NFY B;  2D1J B;  5COX A;  4ISI L;  6COX A;  5KIR A;  3ZYI B;  1CEJ A;  1UZP A;  1ATB A;  4RUT A;  2B7D L;  2XBX L;  1UZJ A;  3FFG L;  1WU1 B;  4ISH L;  5I46 L;  3N8V A;  3LTG D;  1G1T A;  5CIS A;  1C5M F;  3S6X A;  2YGP A;  2VVC K;  2WG3 C;  3BT1 A;  5EGM B;  1YO8 A;  5JB8 E;  4NGA L;  1APO A;  3FBY A;  2HOX A;  4ZXY L;  1HCG B;  5CKM A;  1O5D L;  4BTI A;  2J38 B;  2J4I B;  2RNL A;  3IJE B;  2BT7 A;  4Y71 B;  2VH6 B;  2Y38 A;  1IOX A;  2K2T A;  4Z0K B;  1WHF A;  2W2M E;  1LPK A;  3ENS A;  3TBD A;  3OLU A;  4X8U L;  3H5C B;  1HJ7 A;  2Y7X B;  1P0S L;  2H9E L;  4M10 A;  4JYV L;  1EPI A;  4O02 B;  1IQK L;  1EMO A;  2Q1J B;  1FE2 A;  1NFX B;  3GIS X;  3POY A;  4BTU A;  4XL1 A;  3NJP C;  2HOR A;  1IQJ L;  3CEN L;  2P3U A;  4E1G A;  2WYG B;  1IGX A;  3FCS B;  2W26 B;  3Q3K B;  4GU4 A;  1JBU L;  4MMY B;  3N8W B;  1DDX A;  5L30 L;  1IQM L;  1EGF A;  1URK A;  1DVA L;  2Y5G L;  4RS0 A;  4BDW A;  2Y7Z B;  3GCW E;  1DIY A;  2BT8 A;  1JV2 B;  3LTF B;  4YZU B;  1ADX A;  5JW1 A;  1YGC L;  1KLO A;  2P16 L;  3TK5 B;  3CFW A;  1K37 A;  1IQN L;  2Y5H L;  4CUD A;  2Y82 B;  4GU3 A;  1YUK B;  2UWO B;  1EPG A;  1G1R A;  3MQE A;  1LK9 A;  1LPZ A;  4X8T L;  5IKT A;  1GK5 A;  1G2M B;  2G00 L;  3MDL A;  2XC5 L;  4Y7A B;  2XBY L;  1V1I A;  1EQG A;  1Z6C A;  3ZYJ B;  5K0H B;  3K9X A;  3QCW A;  5F1A A;  2UWP B;  1KIG L;  2RA0 L;  1ZAQ A;  3SOQ A;  4RRZ A;  3ELA L;  3N8Y A;  1NFU B;  4ZHA B;  5JBB E;  5JVY A;  5L2Z L;  4Y7B B;  4C16 A;  5IKV A;  5F19 A;  1HZ8 A;  1AUT L;  1XKA L;  2RHP A;  4ZH8 B;  2XC0 L;  4YT7 L;  1YUF A;  2WPK E;  1QIU A;  1IJQ A;  2WFX B;  2W3I B;  2PUQ L;  2WPJ E;  2FD6 A;  1IQI L;  2Y80 B;  5E8D A;  1IQG L;  1G2L B;  2J2U B;  2OYE P;  1F7E A;  3N8Z A;  4JZF L;  4FM5 A;  3QH0 A;  1FFM A;  2XBV L;  3HO5 A;  1TOZ A;  1EPJ A;  3IIT B;  2P3F L;  2WPH E;  4BDX A;  3TGF A;  4TGF A;  1U67 A;  3N8Y B;  1NZI A;  2FLB L;  4X8V L;  1XFE A;  1HT5 A;  2I9B A;  2FZZ L;  3NT1 A;  1HT8 A;  2PR3 B;  1JL9 A;  3F1S B;  5JBC E;  1V1H A;  3SOV A;  2VWO L;  2BOH A;  3NTB A;  4JZD L;  1FAK L;  1ATD A;  5CKQ A;  3TZI A;  3Q7D A;  2KB9 A;  1COU A;  1EAI C;  3BT2 A;  4BXW A;  5CKN A;  1OB1 C;  1EPH A;  2EI6 B;  1V3X B;  1FF7 A;  1F7M A;  1PRH A;  2WYJ B;  5JB9 E;  4YT6 L;  2VVV L;  3KRK A;  3LN1 A;  3GCX E;  2K2S B;  4XLW A;  1FJS L;  2BQ6 A;  1KLJ L;  2F9B L;  4M11 A;  3SW2 A;  1MOX C;  4CSY A;  2VH0 B;  2DDU A;  1CVU A;  4Z0L A;  1TLE A;  3ASI A;  2BO2 A;  3KQE L;  1A3P A;  1X7A L;  3M37 L;  2JJL A;  1G1S A;  3BPS E;  1K36 A;  2W86 A;  1LMJ A;  1ATE A;  3U7U G;  1SZB A;  1HAF A;  4JZE L;  3LN0 A;  2BZ6 L;  3ZYG A;  5IKQ A;  1W8B L;  3HS6 A;  1IQL L;  2KV4 A;  1IGZ A;  5IKR A;  3V64 C;  3LIW B;  2YGQ A;  1FAX L;  2OYU P;  3N8X A;  1G1Q A;  1WHE A;  4OTJ A;  1KSN B;  1XDT R;  4MMZ B;  1XKB A;  3R05 A;  1IQE L;  1IVO C;  3DEM A;  4Z6A L;  1LPG A;  4AQT A;  1J9C L;  1IQF L;  3TH3 L;  2JKH L;  1P9J A;  4NG9 L;  1N1I A;  3HS7 A;  1F0S B;  5L2Y L;  2H9E C;  1NPE B;  2VWM K;  3F6U L;  4Y76 B;  1EQH A;  2FLG A;  2AYL A;  2MHP A;  2W2N E;  4ZXX L;  4RRY A;  3KL6 B;  1FSB A;  1N7D A;  3HO3 A;  1UZQ A;  4BTT A;  2EI8 B;  2VVU L;  2KNI A;  2BOU A;  2WFT A;  1BF9 A;  3SOB B;  4O1Z A;  3KCG L;  3KQC L;  2J95 B;  2VWN L;  2WPM E;  4BXS A;  2Y81 B;  1DX5 I;  1HX2 A;  1EZQ B;  2WZP P;  1LQD A;  2WPI E;  2PHB B;  2J34 B;  1EBV A;  4CUE A;  4PH9 A;  1CX2 A;  4NA9 L;  1W7X L;  1Q4G A;  4RRX A;  1I0U A;  2BOX A;  1TPG A;  2KL7 A;  1YUG A;  3M36 L;  1Z6E L;  1MQ6 L;  4LMF A;  1PXX A;  3V65 B;  2XBW L;  1F0R B;  3N8W A;  4OTY A;  1RFN B;  4D0F A;  3KQD L;  2MGR A;  2BSF A;  2BQ7 A;  3LAQ A;  2BMG A;  2MGP A;  3RR3 A;  2BOK L;  1ATA A;  2NPR A;  3C9A C;  2UWL B;  4CUF A;  1APQ A;  4XBM A;  3LC3 B;  2P3T A;  1PTH A;  1MQ5 L;  2VWL L;  2W2Q E;  1NQL B;  2GD4 A;  4A7I A;  1IOE L;  2EI7 B;  4Y6D B;  1HAE A;  4MMX B;  1L3Y A;  2VJ3 A;  5KN5 C;  3EGF A;  3HS5 A;  1IP0 A;  3P5B L;  1HRE A;  3NTG A;  1DQB A;  2P3F N;  2ADX A;  4ZAE B;  1M1X B;  2I9A A;  5FDQ A;  2BQW A;  4G1M B;  1B9W A;  2CJI B;  2WPL E;  2XC4 L;  4COX A;  1CCF A;  2P94 L;  2P26 A;  1CQE A;  2Y5F L;  3U73 A;  2J94 B;  4X8S L;  3HPT A;  2WG4 B;  4RRW A;  4A94 C;  2P93 L;  2P28 B;  2W3K B;  2VRS A;  4D0E A;  3KQB L;  1U8C B;  1PFX L;  1NFW B;  1LMM A;  1EMN A;  4LOR A;  2TGF A;  3TK6 B;  3CA7 A;  4Y79 B;  5JBA E;  3OLT A;  2P95 L; 
#chains in the Genus database with same CATH homology
 1CVW L;  3PGH A;  1L5G B;  1PGE A;  3LC5 B;  2FLR L;  1KLI L;  1CCV A;  1QFK L;  3QMO A;  2M74 A;  1UZK A;  2W2P E;  1NT0 A;  3CS7 L;  2W2O E;  4D90 A;  1IQH L;  3HO4 A;  1HRF A;  2YGO A;  5JVZ A;  3KK6 A;  4JYU L;  1NFY B;  2D1J B;  5COX A;  4ISI L;  6COX A;  5KIR A;  3ZYI B;  1CEJ A;  1UZP A;  1ATB A;  4RUT A;  2B7D L;  2XBX L;  1UZJ A;  3FFG L;  1WU1 B;  4ISH L;  5I46 L;  3N8V A;  3LTG D;  1G1T A;  5CIS A;  1C5M F;  3S6X A;  2YGP A;  2VVC K;  2WG3 C;  3BT1 A;  5EGM B;  1YO8 A;  5JB8 E;  4NGA L;  1APO A;  3FBY A;  4ZXY L;  1HCG B;  5CKM A;  1O5D L;  4BTI A;  2J38 B;  2J4I B;  2RNL A;  3IJE B;  4Y71 B;  2VH6 B;  2Y38 A;  1IOX A;  2K2T A;  4Z0K B;  1WHF A;  2W2M E;  1LPK A;  3ENS A;  3TBD A;  3OLU A;  4X8U L;  3H5C B;  1HJ7 A;  2Y7X B;  1P0S L;  2H9E L;  4M10 A;  4JYV L;  1EPI A;  4O02 B;  1IQK L;  1EMO A;  2Q1J B;  1FE2 A;  1NFX B;  3GIS X;  3POY A;  4BTU A;  4XL1 A;  3NJP C;  1IQJ L;  3CEN L;  2P3U A;  4E1G A;  2WYG B;  1IGX A;  3FCS B;  2W26 B;  3Q3K B;  1JBU L;  4MMY B;  3N8W B;  1DDX A;  5L30 L;  1IQM L;  1EGF A;  1URK A;  1DVA L;  2Y5G L;  4RS0 A;  4BDW A;  2Y7Z B;  3GCW E;  1DIY A;  1JV2 B;  3LTF B;  4YZU B;  1ADX A;  5JW1 A;  1YGC L;  1KLO A;  2P16 L;  3TK5 B;  3CFW A;  1K37 A;  1IQN L;  2Y5H L;  4CUD A;  2Y82 B;  1YUK B;  2UWO B;  1EPG A;  1G1R A;  3MQE A;  1LPZ A;  4X8T L;  5IKT A;  1GK5 A;  1G2M B;  2G00 L;  3MDL A;  2XC5 L;  4Y7A B;  2XBY L;  1EQG A;  1Z6C A;  3ZYJ B;  5K0H B;  3K9X A;  3QCW A;  5F1A A;  2UWP B;  1KIG L;  2RA0 L;  1ZAQ A;  3SOQ A;  4RRZ A;  3ELA L;  3N8Y A;  1NFU B;  4ZHA B;  5JBB E;  5JVY A;  5L2Z L;  4Y7B B;  4C16 A;  5IKV A;  5F19 A;  1HZ8 A;  1AUT L;  1XKA L;  2RHP A;  4ZH8 B;  2XC0 L;  4YT7 L;  1YUF A;  2WPK E;  1IJQ A;  2WFX B;  2W3I B;  2PUQ L;  2WPJ E;  2FD6 A;  1IQI L;  2Y80 B;  5E8D A;  1IQG L;  1G2L B;  2J2U B;  2OYE P;  1F7E A;  3N8Z A;  4JZF L;  4FM5 A;  3QH0 A;  1FFM A;  2XBV L;  3HO5 A;  1TOZ A;  1EPJ A;  3IIT B;  2P3F L;  2WPH E;  4BDX A;  3TGF A;  4TGF A;  1U67 A;  3N8Y B;  1NZI A;  2FLB L;  4X8V L;  1XFE A;  1HT5 A;  2I9B A;  2FZZ L;  3NT1 A;  1HT8 A;  2PR3 B;  1JL9 A;  3F1S B;  5JBC E;  3SOV A;  2VWO L;  2BOH A;  3NTB A;  4JZD L;  1FAK L;  1ATD A;  5CKQ A;  3TZI A;  3Q7D A;  2KB9 A;  1COU A;  1EAI C;  3BT2 A;  4BXW A;  5CKN A;  1OB1 C;  1EPH A;  2EI6 B;  1V3X B;  1FF7 A;  1F7M A;  1PRH A;  2WYJ B;  5JB9 E;  4YT6 L;  2VVV L;  3KRK A;  3LN1 A;  3GCX E;  2K2S B;  4XLW A;  1FJS L;  2BQ6 A;  1KLJ L;  2F9B L;  4M11 A;  3SW2 A;  1MOX C;  4CSY A;  2VH0 B;  2DDU A;  1CVU A;  4Z0L A;  1TLE A;  3ASI A;  2BO2 A;  3KQE L;  1A3P A;  1X7A L;  3M37 L;  1G1S A;  3BPS E;  1K36 A;  2W86 A;  1LMJ A;  1ATE A;  3U7U G;  1SZB A;  1HAF A;  4JZE L;  3LN0 A;  2BZ6 L;  3ZYG A;  5IKQ A;  1W8B L;  3HS6 A;  1IQL L;  2KV4 A;  1IGZ A;  5IKR A;  3V64 C;  3LIW B;  2YGQ A;  1FAX L;  2OYU P;  3N8X A;  1G1Q A;  1WHE A;  4OTJ A;  1KSN B;  1XDT R;  4MMZ B;  1XKB A;  3R05 A;  1IQE L;  1IVO C;  3DEM A;  4Z6A L;  1LPG A;  4AQT A;  1J9C L;  1IQF L;  3TH3 L;  2JKH L;  1P9J A;  4NG9 L;  1N1I A;  3HS7 A;  1F0S B;  5L2Y L;  2H9E C;  1NPE B;  2VWM K;  3F6U L;  4Y76 B;  1EQH A;  2FLG A;  2AYL A;  2MHP A;  2W2N E;  4ZXX L;  4RRY A;  3KL6 B;  1FSB A;  1N7D A;  3HO3 A;  1UZQ A;  4BTT A;  2EI8 B;  2VVU L;  2KNI A;  2BOU A;  2WFT A;  1BF9 A;  3SOB B;  4O1Z A;  3KCG L;  3KQC L;  2J95 B;  2VWN L;  2WPM E;  4BXS A;  2Y81 B;  1DX5 I;  1HX2 A;  1EZQ B;  2WZP P;  1LQD A;  2WPI E;  2PHB B;  2J34 B;  1EBV A;  4CUE A;  4PH9 A;  1CX2 A;  4NA9 L;  1W7X L;  1Q4G A;  4RRX A;  1I0U A;  2BOX A;  1TPG A;  2KL7 A;  1YUG A;  3M36 L;  1Z6E L;  1MQ6 L;  4LMF A;  1PXX A;  3V65 B;  2XBW L;  1F0R B;  3N8W A;  4OTY A;  1RFN B;  4D0F A;  3KQD L;  2MGR A;  2BQ7 A;  3LAQ A;  2BMG A;  2MGP A;  3RR3 A;  2BOK L;  1ATA A;  2NPR A;  3C9A C;  2UWL B;  4CUF A;  1APQ A;  4XBM A;  3LC3 B;  2P3T A;  1PTH A;  1MQ5 L;  2VWL L;  2W2Q E;  1NQL B;  2GD4 A;  4A7I A;  1IOE L;  2EI7 B;  4Y6D B;  1HAE A;  4MMX B;  1L3Y A;  2VJ3 A;  5KN5 C;  3EGF A;  3HS5 A;  1IP0 A;  3P5B L;  1HRE A;  3NTG A;  1DQB A;  2P3F N;  2ADX A;  4ZAE B;  1M1X B;  2I9A A;  5FDQ A;  2BQW A;  4G1M B;  1B9W A;  2CJI B;  2WPL E;  2XC4 L;  4COX A;  1CCF A;  2P94 L;  2P26 A;  1CQE A;  2Y5F L;  3U73 A;  2J94 B;  4X8S L;  3HPT A;  2WG4 B;  4RRW A;  4A94 C;  2P93 L;  2P28 B;  2W3K B;  4D0E A;  3KQB L;  1U8C B;  1PFX L;  1NFW B;  1LMM A;  1EMN A;  4LOR A;  2TGF A;  3TK6 B;  3CA7 A;  4Y79 B;  5JBA E;  3OLT A;  2P95 L; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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