4Z0KB

Rapid development of two factor ixa inhibitors from hit to lead
Total Genus 12
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
12
sequence length
55
structure length
55
Chain Sequence
DVTCNIKNGRCEQFCKNSADNKVVCSCTEGYRLAENQKSCEPAVPFPCGRVSVSQ
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Rapid development of two factor IXa inhibitors from hit to lead.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Homo sapiens
molecule keywords Coagulation factor IX
total genus 12
structure length 55
sequence length 55
ec nomenclature ec 3.4.21.22: Coagulation factor IXa.
pdb deposition date 2015-03-26

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF14670 FXa_inhibition Coagulation Factor Xa inhibitory site
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.25.10 Mainly Beta Ribbon Laminin Laminin 4z0kB00
4ISIL 3Q3KB 2MGPA 1IQML 4X8VL 2CJIB 1F7EA 2XBWL 1AUTL 3ZYGA 4ZXYL 3QH0A 1EPIA 3N8ZA 1HZ8A 2W2QE 1KSNB 1XKBA 4MMYB 1YGCL 1M1XB 3RR3A 2P94L 4ZAEB 3M37L 1CCFA 3IJEB 2P3UA 2WYGB 4M11A 1G1RA 1IGXA 1HX2A 2JKHL 3ZYJB 3OLUA 2Y5HL 1C5MF 1UZQA 3HO3A 5L30L 1I0UA 1JV2B 2WYJB 1EMNA 3KL6B 1EPHA 2WPLE 2FD6A 1ADXA 3PGHA 1N7DA 3HS7A 2WPJE 3CFWA 2J94B 1FAXL 2I9AA 3H5CB 2W2PE 3U73A 1HAFA 1QFKL 1V3XB 2XC5L 1TLEA 2G00L 4JYVL 2W2NE 6COXA 1FFMA 5E8DA 2BQ7A 2MGRA 4ZHAB 3GCWE 1HAEA 3HS6A 3POYA 1IQJL 2P3FN 1NFUB 1X7AL 1UZPA 4Z0LA 1DDXA 3N8YB 4LMFA 4YT6L 1FF7A 5F19A 4BTUA 2FZZL 4X8SL 5JBBE 1PTHA 1KIGL 4ISHL 1TOZA 2EI7B 2P3FL 2WPHE 4Z0KB 1MQ6L 3NJPC 4JZDL 2WG3C 3KQDL 1HCGB 1IVOC 1KLJL 3KK6A 1EAIC 2XBVL 4XL1A 2P16L 2WG4B 3BPSE 1DIYA 4TGFA 2P95L 3K9XA 4A7IA 4RRXA 1IQGL 1CEJA 3N8VA 3MQEA 2Y81B 1CCVA 3HS5A 1K36A 3FFGL 2P26A 2K2TA 1Z6EL 1MQ5L 1CQEA 2YGPA 3TK5B 4BTTA 3SOQA 1APOA 2VWOL 1IQEL 1KLIL 1IOXA 1IQHL 2P93L 1EMOA 3C9AC 3LN1A 3ENSA 1IQFL 5L2YL 5COXA 4XBMA 2J2UB 4Y79B 2NPRA 2W26B 3KQEL 4OTJA 1O5DL 1DX5I 1NQLB 2MHPA 2Q1JB 2BQWA 4G1MB 4Y71B 5JVYA 1IQNL 1COUA 2FLRL 2Y38A 5CISA 2F9BL 5K0HB 4RUTA 2OYEP 2VJ3A 4RS0A 1N1IA 1EBVA 3LTGD 1URKA 5CKMA 4YZUB 2UWLB 2WPME 1HJ7A 2W2ME 4D0EA 5KIRA 2BO2A 5JBAE 3ELAL 2FLBL 2RNLA 1G1TA 1PGEA 4NG9L 4CUFA 2W3KB 3CS7L 5IKQA 2VVUL 2BZ6L 2WPKE 1LPZA 2KB9A 1HRFA 4ZH8B 2RA0L 2BMGA 1G2MB 5CKQA 3KQBL 4RRYA 4JZFL 3HO4A 3V64C 4NGAL 3NT1A 2DDUA 4RRZA 5JW1A 3GCXE 4MMZB 3LN0A 2W3IB 3Q7DA 2XBXL 3U7UG 2BOHA 2YGOA 1HT5A 3SW2A 2P28B 1U67A 2VWMK 1UZJA 1XDTR 1IQKL 3SOBB 2BOKL 4CUDA 5CKNA 2VH6B 4BXSA 5IKTA 2Y5FL 2XC4L 1EZQB 2D1JB 1B9WA 5JBCE 1ATAA 1L3YA 1EQHA 1YUGA 2UWPB 3LC3B 2EI6B 2XBYL 2J95B 2BOXA 1FAKL 1A3PA 4XLWA 1CVWL 2VWLL 3HO5A 1L5GB 2KL7A 1ATDA 2FLGA 1XKAL 1P9JA 1ATBA 2I9BA 2WFTA 3BT1A 1ATEA 1JBUL 2VVVL 1RFNB 2VH0B 2Y7XB 4Y7BB 3R05A 2J34B 2TGFA 1LPKA 1Z6CA 3TH3L 5FDQA 4JYUL 2Y80B 1Q4GA 1IOEL 4AQTA 3OLTA 1WU1B 4O1ZA 4MMXB 1KLOA 2PUQL 1IP0A 1DQBA 3GISX 4BXWA 4X8TL 1IGZA 5KN5C 3TBDA 4E1GA 5JVZA 1F7MA 5F1AA 1NZIA 1EQGA 3F6UL 2B7DL 2Y7ZB 3QMOA 3ZYIB 2KV4A 2Y82B 2VVCK 1YUKB 2VWNL 4Y76B 1NFXB 5L2ZL 1HT8A 1F0SB 2BQ6A 1U8CB 1CX2A 1EPJA 4PH9A 2RHPA 3N8WB 5IKRA 1FJSL 1G1QA 3TZIA 1K37A 4D90A 4NA9L 2K2SB 4LORA 4YT7L 3TGFA 3TK6B 4CSYA 1P0SL 1G2LB 4CUEA 3V65B 3LC5B 1LQDA 1W7XL 5I46L 2XC0L 3N8XA 5JB8E 1WHEA 5EGMB 2WFXB 1IQIL 3BT2A 3HPTA 2J4IB 4RRWA 4Y6DB 2WPIE 3KRKA 5JB9E 1UZKA 1XFEA 1J9CL 4M10A 1PXXA 4COXA 3NTBA 3FBYA 2H9EL 2ADXA 1APQA 1DVAL 3IITB 3MDLA 1NFYB 1CVUA 1FSBA 2GD4A 3N8WA 2BOUA 4Y7AB 1W8BL 4JZEL 4C16A 1MOXC 1EPGA 1FE2A 1HREA 1OB1C 1LMJA 4BDWA 2PHBB 3M36L 2W86A 3NTGA 1YUFA 3F1SB 4X8UL 5IKVA 1GK5A 1SZBA 1NFWB 2P3TA 1JL9A 3ASIA 1PFXL 1PRHA 2PR3B 2AYLA 1TPGA 2OYUP 1F0RB 1LPGA 2M74A 3DEMA 3LAQA 4D0FA 4BDXA 2EI8B 2W2OE 1YO8A 4FM5A 2UWOB 3KCGL 4BTIA 2Y5GL 1IJQA 2J38B 3KQCL 3LIWB 3QCWA 1BF9A 1G1SA 1ZAQA 4Z6AL 1NPEB 4OTYA 3CA7A 1IQLL 3CENL 4O02B 4ZXXL 3SOVA 1NT0A 3P5BL 3LTFB 3EGFA 3N8YA 1EGFA 1WHFA 3FCSB
chains in the Genus database with same CATH superfamily
4ISIL 3Q3KB 2MGPA 1IQML 4X8VL 2CJIB 1F7EA 2XBWL 1AUTL 3ZYGA 4ZXYL 3QH0A 1EPIA 3N8ZA 1HZ8A 2W2QE 1KSNB 1XKBA 4MMYB 1YGCL 1M1XB 3RR3A 2P94L 4ZAEB 3M37L 1CCFA 3IJEB 2P3UA 2WYGB 4M11A 1G1RA 1IGXA 1HX2A 2JKHL 3ZYJB 3OLUA 2Y5HL 1C5MF 1UZQA 3HO3A 5L30L 1I0UA 1JV2B 2WYJB 1EMNA 3KL6B 1EPHA 2WPLE 2FD6A 1ADXA 3PGHA 1N7DA 3HS7A 2WPJE 3CFWA 2J94B 1FAXL 2BT7A 2I9AA 3H5CB 2W2PE 3U73A 1HAFA 1QFKL 1V3XB 2XC5L 1TLEA 2BT8A 2G00L 4JYVL 2W2NE 6COXA 1FFMA 5E8DA 2BQ7A 2MGRA 4ZHAB 3GCWE 1HAEA 3HS6A 3POYA 1IQJL 2P3FN 1NFUB 1X7AL 1UZPA 4Z0LA 1DDXA 3N8YB 4LMFA 4YT6L 1FF7A 5F19A 4BTUA 2FZZL 4X8SL 5JBBE 1PTHA 1KIGL 4ISHL 1TOZA 2EI7B 2P3FL 2WPHE 4Z0KB 1MQ6L 3NJPC 4JZDL 2WG3C 3KQDL 1HCGB 4GU4A 1IVOC 1KLJL 3KK6A 1EAIC 2XBVL 4XL1A 2P16L 2WG4B 3BPSE 1DIYA 4TGFA 2P95L 3K9XA 4A7IA 4RRXA 1IQGL 1CEJA 3N8VA 3MQEA 2Y81B 1CCVA 3HS5A 1K36A 3FFGL 2P26A 2K2TA 1Z6EL 3S6XA 1MQ5L 1CQEA 2YGPA 3TK5B 4BTTA 3SOQA 1APOA 2VWOL 1IQEL 1KLIL 1IOXA 1IQHL 2P93L 2YGQA 1EMOA 3C9AC 3LN1A 3ENSA 1LK9A 1IQFL 5L2YL 5COXA 4XBMA 2J2UB 4Y79B 2NPRA 2W26B 3KQEL 4OTJA 1O5DL 1DX5I 1NQLB 2MHPA 2Q1JB 2BQWA 4G1MB 4Y71B 5JVYA 1IQNL 1COUA 2FLRL 2Y38A 5CISA 2F9BL 5K0HB 4RUTA 2OYEP 2VJ3A 4RS0A 1N1IA 1EBVA 3LTGD 1URKA 5CKMA 4YZUB 2UWLB 2WPME 1HJ7A 2W2ME 4D0EA 5KIRA 2BO2A 5JBAE 3ELAL 2FLBL 2RNLA 1G1TA 1PGEA 4NG9L 4CUFA 2W3KB 3CS7L 5IKQA 2VVUL 2BZ6L 2WPKE 1LPZA 2KB9A 1HRFA 4ZH8B 2RA0L 2BMGA 1G2MB 5CKQA 3KQBL 4RRYA 4JZFL 3HO4A 3V64C 4NGAL 3NT1A 4A94C 2DDUA 4RRZA 5JW1A 3GCXE 4MMZB 3LN0A 2W3IB 3Q7DA 2XBXL 3U7UG 2BOHA 2YGOA 1HT5A 3SW2A 2P28B 1U67A 2VWMK 1UZJA 1XDTR 1IQKL 3SOBB 2BOKL 4CUDA 2HORA 5CKNA 2VH6B 4BXSA 5IKTA 2Y5FL 2XC4L 1EZQB 2D1JB 1B9WA 5JBCE 1ATAA 1L3YA 1EQHA 1YUGA 2UWPB 3LC3B 2EI6B 2XBYL 2J95B 2BOXA 1FAKL 1A3PA 4XLWA 1CVWL 2VWLL 3HO5A 1L5GB 2KL7A 1ATDA 2FLGA 1XKAL 1P9JA 1ATBA 2I9BA 2WFTA 3BT1A 1ATEA 1JBUL 2VVVL 1RFNB 4GU3A 2VH0B 2Y7XB 4Y7BB 3R05A 2J34B 1KKEA 2TGFA 1LPKA 1Z6CA 3TH3L 5FDQA 4JYUL 2Y80B 1Q4GA 2WZPP 1IOEL 4AQTA 3OLTA 1WU1B 4O1ZA 4MMXB 1KLOA 2PUQL 1IP0A 1V1HA 1DQBA 3GISX 4BXWA 4X8TL 1IGZA 5KN5C 3TBDA 4E1GA 5JVZA 1F7MA 5F1AA 1NZIA 1EQGA 3F6UL 2VRSA 1V1IA 2B7DL 2Y7ZB 3QMOA 3ZYIB 2KV4A 2Y82B 2VVCK 1YUKB 2VWNL 4Y76B 1NFXB 5L2ZL 1HT8A 1F0SB 2JJLA 2BQ6A 1LMMA 1U8CB 1CX2A 1EPJA 4PH9A 2RHPA 3N8WB 5IKRA 1FJSL 1G1QA 3TZIA 1K37A 4D90A 4NA9L 2K2SB 4LORA 4YT7L 3TGFA 3TK6B 4CSYA 1P0SL 1G2LB 4CUEA 2BSFA 3V65B 3LC5B 1LQDA 1W7XL 5I46L 2XC0L 3N8XA 5JB8E 1WHEA 5EGMB 2WFXB 1IQIL 2H9EC 3BT2A 3HPTA 2J4IB 4RRWA 4Y6DB 2WPIE 3KRKA 5JB9E 1UZKA 1XFEA 1J9CL 4M10A 1PXXA 4COXA 3NTBA 3FBYA 2H9EL 1QIUA 2ADXA 1APQA 1DVAL 3IITB 3MDLA 1NFYB 1CVUA 1FSBA 2GD4A 3N8WA 2BOUA 4Y7AB 1W8BL 4JZEL 4C16A 1MOXC 1EPGA 1FE2A 1HREA 1OB1C 1LMJA 4BDWA 2PHBB 3M36L 2W86A 3NTGA 1YUFA 3F1SB 4X8UL 5IKVA 1GK5A 1SZBA 1NFWB 2P3TA 1JL9A 3ASIA 1PFXL 1PRHA 2PR3B 2AYLA 1TPGA 2OYUP 1F0RB 1LPGA 2M74A 3DEMA 3LAQA 4D0FA 4BDXA 2EI8B 2W2OE 1YO8A 4FM5A 2UWOB 3KCGL 4BTIA 2KNIA 2Y5GL 1IJQA 2J38B 3KQCL 3LIWB 3QCWA 1BF9A 1G1SA 1ZAQA 4Z6AL 1NPEB 4OTYA 3CA7A 1IQLL 3CENL 4O02B 4ZXXL 3SOVA 1NT0A 3P5BL 3LTFB 2HOXA 3EGFA 3N8YA 1EGFA 1WHFA 3FCSB
chains in the Genus database with same CATH topology
4ISIL 3Q3KB 2MGPA 1IQML 4X8VL 2CJIB 1F7EA 2XBWL 1AUTL 3ZYGA 4ZXYL 3QH0A 1EPIA 3N8ZA 1HZ8A 2W2QE 1KSNB 1XKBA 4MMYB 1YGCL 1M1XB 3RR3A 2P94L 4ZAEB 3M37L 1CCFA 3IJEB 2P3UA 2WYGB 4M11A 1G1RA 1IGXA 1HX2A 2JKHL 3ZYJB 3OLUA 2Y5HL 1C5MF 1UZQA 3HO3A 5L30L 1I0UA 1JV2B 2WYJB 1EMNA 3KL6B 1EPHA 2WPLE 2FD6A 1ADXA 3PGHA 1N7DA 3HS7A 2WPJE 3CFWA 2J94B 1FAXL 2I9AA 3H5CB 2W2PE 3U73A 1HAFA 1QFKL 1V3XB 2XC5L 1TLEA 2G00L 4JYVL 2W2NE 6COXA 1FFMA 5E8DA 2BQ7A 2MGRA 4ZHAB 3GCWE 1HAEA 3HS6A 3POYA 1IQJL 2P3FN 1NFUB 1X7AL 1UZPA 4Z0LA 1DDXA 3N8YB 4LMFA 4YT6L 1FF7A 5F19A 4BTUA 2FZZL 4X8SL 5JBBE 1PTHA 1KIGL 4ISHL 1TOZA 2EI7B 2P3FL 2WPHE 4Z0KB 1MQ6L 3NJPC 4JZDL 2WG3C 3KQDL 1HCGB 1IVOC 1KLJL 3KK6A 1EAIC 2XBVL 4XL1A 2P16L 2WG4B 3BPSE 1DIYA 4TGFA 2P95L 3K9XA 4A7IA 4RRXA 1IQGL 1CEJA 3N8VA 3MQEA 2Y81B 1CCVA 3HS5A 1K36A 3FFGL 2P26A 2K2TA 1Z6EL 3S6XA 1MQ5L 1CQEA 2YGPA 3TK5B 4BTTA 3SOQA 1APOA 2VWOL 1IQEL 1KLIL 1IOXA 1IQHL 2P93L 2YGQA 1EMOA 3C9AC 3LN1A 3ENSA 1IQFL 5L2YL 5COXA 4XBMA 2J2UB 4Y79B 2NPRA 2W26B 3KQEL 4OTJA 1O5DL 1DX5I 1NQLB 2MHPA 2Q1JB 2BQWA 4G1MB 4Y71B 5JVYA 1IQNL 1COUA 2FLRL 2Y38A 5CISA 2F9BL 5K0HB 4RUTA 2OYEP 2VJ3A 4RS0A 1N1IA 1EBVA 3LTGD 1URKA 5CKMA 4YZUB 2UWLB 2WPME 1HJ7A 2W2ME 4D0EA 5KIRA 2BO2A 5JBAE 3ELAL 2FLBL 2RNLA 1G1TA 1PGEA 4NG9L 4CUFA 2W3KB 3CS7L 5IKQA 2VVUL 2BZ6L 2WPKE 1LPZA 2KB9A 1HRFA 4ZH8B 2RA0L 2BMGA 1G2MB 5CKQA 3KQBL 4RRYA 4JZFL 3HO4A 3V64C 4NGAL 3NT1A 4A94C 2DDUA 4RRZA 5JW1A 3GCXE 4MMZB 3LN0A 2W3IB 3Q7DA 2XBXL 3U7UG 2BOHA 2YGOA 1HT5A 3SW2A 2P28B 1U67A 2VWMK 1UZJA 1XDTR 1IQKL 3SOBB 2BOKL 4CUDA 5CKNA 2VH6B 4BXSA 5IKTA 2Y5FL 2XC4L 1EZQB 2D1JB 1B9WA 5JBCE 1ATAA 1L3YA 1EQHA 1YUGA 2UWPB 3LC3B 2EI6B 2XBYL 2J95B 2BOXA 1FAKL 1A3PA 4XLWA 1CVWL 2VWLL 3HO5A 1L5GB 2KL7A 1ATDA 2FLGA 1XKAL 1P9JA 1ATBA 2I9BA 2WFTA 3BT1A 1ATEA 1JBUL 2VVVL 1RFNB 2VH0B 2Y7XB 4Y7BB 3R05A 2J34B 2TGFA 1LPKA 1Z6CA 3TH3L 5FDQA 4JYUL 2Y80B 1Q4GA 2WZPP 1IOEL 4AQTA 3OLTA 1WU1B 4O1ZA 4MMXB 1KLOA 2PUQL 1IP0A 1DQBA 3GISX 4BXWA 4X8TL 1IGZA 5KN5C 3TBDA 4E1GA 5JVZA 1F7MA 5F1AA 1NZIA 1EQGA 3F6UL 2B7DL 2Y7ZB 3QMOA 3ZYIB 2KV4A 2Y82B 2VVCK 1YUKB 2VWNL 4Y76B 1NFXB 5L2ZL 1HT8A 1F0SB 2BQ6A 1LMMA 1U8CB 1CX2A 1EPJA 4PH9A 2RHPA 3N8WB 5IKRA 1FJSL 1G1QA 3TZIA 1K37A 4D90A 4NA9L 2K2SB 4LORA 4YT7L 3TGFA 3TK6B 4CSYA 1P0SL 1G2LB 4CUEA 3V65B 3LC5B 1LQDA 1W7XL 5I46L 2XC0L 3N8XA 5JB8E 1WHEA 5EGMB 2WFXB 1IQIL 2H9EC 3BT2A 3HPTA 2J4IB 4RRWA 4Y6DB 2WPIE 3KRKA 5JB9E 1UZKA 1XFEA 1J9CL 4M10A 1PXXA 4COXA 3NTBA 3FBYA 2H9EL 2ADXA 1APQA 1DVAL 3IITB 3MDLA 1NFYB 1CVUA 1FSBA 2GD4A 3N8WA 2BOUA 4Y7AB 1W8BL 4JZEL 4C16A 1MOXC 1EPGA 1FE2A 1HREA 1OB1C 1LMJA 4BDWA 2PHBB 3M36L 2W86A 3NTGA 1YUFA 3F1SB 4X8UL 5IKVA 1GK5A 1SZBA 1NFWB 2P3TA 1JL9A 3ASIA 1PFXL 1PRHA 2PR3B 2AYLA 1TPGA 2OYUP 1F0RB 1LPGA 2M74A 3DEMA 3LAQA 4D0FA 4BDXA 2EI8B 2W2OE 1YO8A 4FM5A 2UWOB 3KCGL 4BTIA 2KNIA 2Y5GL 1IJQA 2J38B 3KQCL 3LIWB 3QCWA 1BF9A 1G1SA 1ZAQA 4Z6AL 1NPEB 4OTYA 3CA7A 1IQLL 3CENL 4O02B 4ZXXL 3SOVA 1NT0A 3P5BL 3LTFB 3EGFA 3N8YA 1EGFA 1WHFA 3FCSB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4ISI L;  3Q3K B;  2MGP A;  1IQM L;  4X8V L;  2CJI B;  1F7E A;  2XBW L;  1AUT L;  3ZYG A;  4ZXY L;  3QH0 A;  1EPI A;  3N8Z A;  1HZ8 A;  2W2Q E;  1KSN B;  1XKB A;  4MMY B;  1YGC L;  1M1X B;  3RR3 A;  2P94 L;  4ZAE B;  3M37 L;  1CCF A;  3IJE B;  2P3U A;  2WYG B;  4M11 A;  1G1R A;  1IGX A;  1HX2 A;  2JKH L;  3ZYJ B;  3OLU A;  2Y5H L;  1C5M F;  1UZQ A;  3HO3 A;  5L30 L;  1I0U A;  1JV2 B;  2WYJ B;  1EMN A;  3KL6 B;  1EPH A;  2WPL E;  2FD6 A;  1ADX A;  3PGH A;  1N7D A;  3HS7 A;  2WPJ E;  3CFW A;  2J94 B;  1FAX L;  2I9A A;  3H5C B;  2W2P E;  3U73 A;  1HAF A;  1QFK L;  1V3X B;  2XC5 L;  1TLE A;  2G00 L;  4JYV L;  2W2N E;  6COX A;  1FFM A;  5E8D A;  2BQ7 A;  2MGR A;  4ZHA B;  3GCW E;  1HAE A;  3HS6 A;  3POY A;  1IQJ L;  2P3F N;  1NFU B;  1X7A L;  1UZP A;  4Z0L A;  1DDX A;  3N8Y B;  4LMF A;  4YT6 L;  1FF7 A;  5F19 A;  4BTU A;  2FZZ L;  4X8S L;  5JBB E;  1PTH A;  1KIG L;  4ISH L;  1TOZ A;  2EI7 B;  2P3F L;  2WPH E;  4Z0K B;  1MQ6 L;  3NJP C;  4JZD L;  2WG3 C;  3KQD L;  1HCG B;  1IVO C;  1KLJ L;  3KK6 A;  1EAI C;  2XBV L;  4XL1 A;  2P16 L;  2WG4 B;  3BPS E;  1DIY A;  4TGF A;  2P95 L;  3K9X A;  4A7I A;  4RRX A;  1IQG L;  1CEJ A;  3N8V A;  3MQE A;  2Y81 B;  1CCV A;  3HS5 A;  1K36 A;  3FFG L;  2P26 A;  2K2T A;  1Z6E L;  1MQ5 L;  1CQE A;  2YGP A;  3TK5 B;  4BTT A;  3SOQ A;  1APO A;  2VWO L;  1IQE L;  1KLI L;  1IOX A;  1IQH L;  2P93 L;  1EMO A;  3C9A C;  3LN1 A;  3ENS A;  1IQF L;  5L2Y L;  5COX A;  4XBM A;  2J2U B;  4Y79 B;  2NPR A;  2W26 B;  3KQE L;  4OTJ A;  1O5D L;  1DX5 I;  1NQL B;  2MHP A;  2Q1J B;  2BQW A;  4G1M B;  4Y71 B;  5JVY A;  1IQN L;  1COU A;  2FLR L;  2Y38 A;  5CIS A;  2F9B L;  5K0H B;  4RUT A;  2OYE P;  2VJ3 A;  4RS0 A;  1N1I A;  1EBV A;  3LTG D;  1URK A;  5CKM A;  4YZU B;  2UWL B;  2WPM E;  1HJ7 A;  2W2M E;  4D0E A;  5KIR A;  2BO2 A;  5JBA E;  3ELA L;  2FLB L;  2RNL A;  1G1T A;  1PGE A;  4NG9 L;  4CUF A;  2W3K B;  3CS7 L;  5IKQ A;  2VVU L;  2BZ6 L;  2WPK E;  1LPZ A;  2KB9 A;  1HRF A;  4ZH8 B;  2RA0 L;  2BMG A;  1G2M B;  5CKQ A;  3KQB L;  4RRY A;  4JZF L;  3HO4 A;  3V64 C;  4NGA L;  3NT1 A;  2DDU A;  4RRZ A;  5JW1 A;  3GCX E;  4MMZ B;  3LN0 A;  2W3I B;  3Q7D A;  2XBX L;  3U7U G;  2BOH A;  2YGO A;  1HT5 A;  3SW2 A;  2P28 B;  1U67 A;  2VWM K;  1UZJ A;  1XDT R;  1IQK L;  3SOB B;  2BOK L;  4CUD A;  5CKN A;  2VH6 B;  4BXS A;  5IKT A;  2Y5F L;  2XC4 L;  1EZQ B;  2D1J B;  1B9W A;  5JBC E;  1ATA A;  1L3Y A;  1EQH A;  1YUG A;  2UWP B;  3LC3 B;  2EI6 B;  2XBY L;  2J95 B;  2BOX A;  1FAK L;  1A3P A;  4XLW A;  1CVW L;  2VWL L;  3HO5 A;  1L5G B;  2KL7 A;  1ATD A;  2FLG A;  1XKA L;  1P9J A;  1ATB A;  2I9B A;  2WFT A;  3BT1 A;  1ATE A;  1JBU L;  2VVV L;  1RFN B;  2VH0 B;  2Y7X B;  4Y7B B;  3R05 A;  2J34 B;  2TGF A;  1LPK A;  1Z6C A;  3TH3 L;  5FDQ A;  4JYU L;  2Y80 B;  1Q4G A;  1IOE L;  4AQT A;  3OLT A;  1WU1 B;  4O1Z A;  4MMX B;  1KLO A;  2PUQ L;  1IP0 A;  1DQB A;  3GIS X;  4BXW A;  4X8T L;  1IGZ A;  5KN5 C;  3TBD A;  4E1G A;  5JVZ A;  1F7M A;  5F1A A;  1NZI A;  1EQG A;  3F6U L;  2B7D L;  2Y7Z B;  3QMO A;  3ZYI B;  2KV4 A;  2Y82 B;  2VVC K;  1YUK B;  2VWN L;  4Y76 B;  1NFX B;  5L2Z L;  1HT8 A;  1F0S B;  2BQ6 A;  1U8C B;  1CX2 A;  1EPJ A;  4PH9 A;  2RHP A;  3N8W B;  5IKR A;  1FJS L;  1G1Q A;  3TZI A;  1K37 A;  4D90 A;  4NA9 L;  2K2S B;  4LOR A;  4YT7 L;  3TGF A;  3TK6 B;  4CSY A;  1P0S L;  1G2L B;  4CUE A;  3V65 B;  3LC5 B;  1LQD A;  1W7X L;  5I46 L;  2XC0 L;  3N8X A;  5JB8 E;  1WHE A;  5EGM B;  2WFX B;  1IQI L;  3BT2 A;  3HPT A;  2J4I B;  4RRW A;  4Y6D B;  2WPI E;  3KRK A;  5JB9 E;  1UZK A;  1XFE A;  1J9C L;  4M10 A;  1PXX A;  4COX A;  3NTB A;  3FBY A;  2H9E L;  2ADX A;  1APQ A;  1DVA L;  3IIT B;  3MDL A;  1NFY B;  1CVU A;  1FSB A;  2GD4 A;  3N8W A;  2BOU A;  4Y7A B;  1W8B L;  4JZE L;  4C16 A;  1MOX C;  1EPG A;  1FE2 A;  1HRE A;  1OB1 C;  1LMJ A;  4BDW A;  2PHB B;  3M36 L;  2W86 A;  3NTG A;  1YUF A;  3F1S B;  4X8U L;  5IKV A;  1GK5 A;  1SZB A;  1NFW B;  2P3T A;  1JL9 A;  3ASI A;  1PFX L;  1PRH A;  2PR3 B;  2AYL A;  1TPG A;  2OYU P;  1F0R B;  1LPG A;  2M74 A;  3DEM A;  3LAQ A;  4D0F A;  4BDX A;  2EI8 B;  2W2O E;  1YO8 A;  4FM5 A;  2UWO B;  3KCG L;  4BTI A;  2Y5G L;  1IJQ A;  2J38 B;  3KQC L;  3LIW B;  3QCW A;  1BF9 A;  1G1S A;  1ZAQ A;  4Z6A L;  1NPE B;  4OTY A;  3CA7 A;  1IQL L;  3CEN L;  4O02 B;  4ZXX L;  3SOV A;  1NT0 A;  3P5B L;  3LTF B;  3EGF A;  3N8Y A;  1EGF A;  1WHF A;  3FCS B; 
#chains in the Genus database with same CATH topology
 4ISI L;  3Q3K B;  2MGP A;  1IQM L;  4X8V L;  2CJI B;  1F7E A;  2XBW L;  1AUT L;  3ZYG A;  4ZXY L;  3QH0 A;  1EPI A;  3N8Z A;  1HZ8 A;  2W2Q E;  1KSN B;  1XKB A;  4MMY B;  1YGC L;  1M1X B;  3RR3 A;  2P94 L;  4ZAE B;  3M37 L;  1CCF A;  3IJE B;  2P3U A;  2WYG B;  4M11 A;  1G1R A;  1IGX A;  1HX2 A;  2JKH L;  3ZYJ B;  3OLU A;  2Y5H L;  1C5M F;  1UZQ A;  3HO3 A;  5L30 L;  1I0U A;  1JV2 B;  2WYJ B;  1EMN A;  3KL6 B;  1EPH A;  2WPL E;  2FD6 A;  1ADX A;  3PGH A;  1N7D A;  3HS7 A;  2WPJ E;  3CFW A;  2J94 B;  1FAX L;  2BT7 A;  2I9A A;  3H5C B;  2W2P E;  3U73 A;  1HAF A;  1QFK L;  1V3X B;  2XC5 L;  1TLE A;  2BT8 A;  2G00 L;  4JYV L;  2W2N E;  6COX A;  1FFM A;  5E8D A;  2BQ7 A;  2MGR A;  4ZHA B;  3GCW E;  1HAE A;  3HS6 A;  3POY A;  1IQJ L;  2P3F N;  1NFU B;  1X7A L;  1UZP A;  4Z0L A;  1DDX A;  3N8Y B;  4LMF A;  4YT6 L;  1FF7 A;  5F19 A;  4BTU A;  2FZZ L;  4X8S L;  5JBB E;  1PTH A;  1KIG L;  4ISH L;  1TOZ A;  2EI7 B;  2P3F L;  2WPH E;  4Z0K B;  1MQ6 L;  3NJP C;  4JZD L;  2WG3 C;  3KQD L;  1HCG B;  4GU4 A;  1IVO C;  1KLJ L;  3KK6 A;  1EAI C;  2XBV L;  4XL1 A;  2P16 L;  2WG4 B;  3BPS E;  1DIY A;  4TGF A;  2P95 L;  3K9X A;  4A7I A;  4RRX A;  1IQG L;  1CEJ A;  3N8V A;  3MQE A;  2Y81 B;  1CCV A;  3HS5 A;  1K36 A;  3FFG L;  2P26 A;  2K2T A;  1Z6E L;  3S6X A;  1MQ5 L;  1CQE A;  2YGP A;  3TK5 B;  4BTT A;  3SOQ A;  1APO A;  2VWO L;  1IQE L;  1KLI L;  1IOX A;  1IQH L;  2P93 L;  2YGQ A;  1EMO A;  3C9A C;  3LN1 A;  3ENS A;  1LK9 A;  1IQF L;  5L2Y L;  5COX A;  4XBM A;  2J2U B;  4Y79 B;  2NPR A;  2W26 B;  3KQE L;  4OTJ A;  1O5D L;  1DX5 I;  1NQL B;  2MHP A;  2Q1J B;  2BQW A;  4G1M B;  4Y71 B;  5JVY A;  1IQN L;  1COU A;  2FLR L;  2Y38 A;  5CIS A;  2F9B L;  5K0H B;  4RUT A;  2OYE P;  2VJ3 A;  4RS0 A;  1N1I A;  1EBV A;  3LTG D;  1URK A;  5CKM A;  4YZU B;  2UWL B;  2WPM E;  1HJ7 A;  2W2M E;  4D0E A;  5KIR A;  2BO2 A;  5JBA E;  3ELA L;  2FLB L;  2RNL A;  1G1T A;  1PGE A;  4NG9 L;  4CUF A;  2W3K B;  3CS7 L;  5IKQ A;  2VVU L;  2BZ6 L;  2WPK E;  1LPZ A;  2KB9 A;  1HRF A;  4ZH8 B;  2RA0 L;  2BMG A;  1G2M B;  5CKQ A;  3KQB L;  4RRY A;  4JZF L;  3HO4 A;  3V64 C;  4NGA L;  3NT1 A;  4A94 C;  2DDU A;  4RRZ A;  5JW1 A;  3GCX E;  4MMZ B;  3LN0 A;  2W3I B;  3Q7D A;  2XBX L;  3U7U G;  2BOH A;  2YGO A;  1HT5 A;  3SW2 A;  2P28 B;  1U67 A;  2VWM K;  1UZJ A;  1XDT R;  1IQK L;  3SOB B;  2BOK L;  4CUD A;  2HOR A;  5CKN A;  2VH6 B;  4BXS A;  5IKT A;  2Y5F L;  2XC4 L;  1EZQ B;  2D1J B;  1B9W A;  5JBC E;  1ATA A;  1L3Y A;  1EQH A;  1YUG A;  2UWP B;  3LC3 B;  2EI6 B;  2XBY L;  2J95 B;  2BOX A;  1FAK L;  1A3P A;  4XLW A;  1CVW L;  2VWL L;  3HO5 A;  1L5G B;  2KL7 A;  1ATD A;  2FLG A;  1XKA L;  1P9J A;  1ATB A;  2I9B A;  2WFT A;  3BT1 A;  1ATE A;  1JBU L;  2VVV L;  1RFN B;  4GU3 A;  2VH0 B;  2Y7X B;  4Y7B B;  3R05 A;  2J34 B;  1KKE A;  2TGF A;  1LPK A;  1Z6C A;  3TH3 L;  5FDQ A;  4JYU L;  2Y80 B;  1Q4G A;  2WZP P;  1IOE L;  4AQT A;  3OLT A;  1WU1 B;  4O1Z A;  4MMX B;  1KLO A;  2PUQ L;  1IP0 A;  1V1H A;  1DQB A;  3GIS X;  4BXW A;  4X8T L;  1IGZ A;  5KN5 C;  3TBD A;  4E1G A;  5JVZ A;  1F7M A;  5F1A A;  1NZI A;  1EQG A;  3F6U L;  2VRS A;  1V1I A;  2B7D L;  2Y7Z B;  3QMO A;  3ZYI B;  2KV4 A;  2Y82 B;  2VVC K;  1YUK B;  2VWN L;  4Y76 B;  1NFX B;  5L2Z L;  1HT8 A;  1F0S B;  2JJL A;  2BQ6 A;  1LMM A;  1U8C B;  1CX2 A;  1EPJ A;  4PH9 A;  2RHP A;  3N8W B;  5IKR A;  1FJS L;  1G1Q A;  3TZI A;  1K37 A;  4D90 A;  4NA9 L;  2K2S B;  4LOR A;  4YT7 L;  3TGF A;  3TK6 B;  4CSY A;  1P0S L;  1G2L B;  4CUE A;  2BSF A;  3V65 B;  3LC5 B;  1LQD A;  1W7X L;  5I46 L;  2XC0 L;  3N8X A;  5JB8 E;  1WHE A;  5EGM B;  2WFX B;  1IQI L;  2H9E C;  3BT2 A;  3HPT A;  2J4I B;  4RRW A;  4Y6D B;  2WPI E;  3KRK A;  5JB9 E;  1UZK A;  1XFE A;  1J9C L;  4M10 A;  1PXX A;  4COX A;  3NTB A;  3FBY A;  2H9E L;  1QIU A;  2ADX A;  1APQ A;  1DVA L;  3IIT B;  3MDL A;  1NFY B;  1CVU A;  1FSB A;  2GD4 A;  3N8W A;  2BOU A;  4Y7A B;  1W8B L;  4JZE L;  4C16 A;  1MOX C;  1EPG A;  1FE2 A;  1HRE A;  1OB1 C;  1LMJ A;  4BDW A;  2PHB B;  3M36 L;  2W86 A;  3NTG A;  1YUF A;  3F1S B;  4X8U L;  5IKV A;  1GK5 A;  1SZB A;  1NFW B;  2P3T A;  1JL9 A;  3ASI A;  1PFX L;  1PRH A;  2PR3 B;  2AYL A;  1TPG A;  2OYU P;  1F0R B;  1LPG A;  2M74 A;  3DEM A;  3LAQ A;  4D0F A;  4BDX A;  2EI8 B;  2W2O E;  1YO8 A;  4FM5 A;  2UWO B;  3KCG L;  4BTI A;  2KNI A;  2Y5G L;  1IJQ A;  2J38 B;  3KQC L;  3LIW B;  3QCW A;  1BF9 A;  1G1S A;  1ZAQ A;  4Z6A L;  1NPE B;  4OTY A;  3CA7 A;  1IQL L;  3CEN L;  4O02 B;  4ZXX L;  3SOV A;  1NT0 A;  3P5B L;  3LTF B;  2HOX A;  3EGF A;  3N8Y A;  1EGF A;  1WHF A;  3FCS B; 
#chains in the Genus database with same CATH homology
 4ISI L;  3Q3K B;  2MGP A;  1IQM L;  4X8V L;  2CJI B;  1F7E A;  2XBW L;  1AUT L;  3ZYG A;  4ZXY L;  3QH0 A;  1EPI A;  3N8Z A;  1HZ8 A;  2W2Q E;  1KSN B;  1XKB A;  4MMY B;  1YGC L;  1M1X B;  3RR3 A;  2P94 L;  4ZAE B;  3M37 L;  1CCF A;  3IJE B;  2P3U A;  2WYG B;  4M11 A;  1G1R A;  1IGX A;  1HX2 A;  2JKH L;  3ZYJ B;  3OLU A;  2Y5H L;  1C5M F;  1UZQ A;  3HO3 A;  5L30 L;  1I0U A;  1JV2 B;  2WYJ B;  1EMN A;  3KL6 B;  1EPH A;  2WPL E;  2FD6 A;  1ADX A;  3PGH A;  1N7D A;  3HS7 A;  2WPJ E;  3CFW A;  2J94 B;  1FAX L;  2I9A A;  3H5C B;  2W2P E;  3U73 A;  1HAF A;  1QFK L;  1V3X B;  2XC5 L;  1TLE A;  2G00 L;  4JYV L;  2W2N E;  6COX A;  1FFM A;  5E8D A;  2BQ7 A;  2MGR A;  4ZHA B;  3GCW E;  1HAE A;  3HS6 A;  3POY A;  1IQJ L;  2P3F N;  1NFU B;  1X7A L;  1UZP A;  4Z0L A;  1DDX A;  3N8Y B;  4LMF A;  4YT6 L;  1FF7 A;  5F19 A;  4BTU A;  2FZZ L;  4X8S L;  5JBB E;  1PTH A;  1KIG L;  4ISH L;  1TOZ A;  2EI7 B;  2P3F L;  2WPH E;  4Z0K B;  1MQ6 L;  3NJP C;  4JZD L;  2WG3 C;  3KQD L;  1HCG B;  1IVO C;  1KLJ L;  3KK6 A;  1EAI C;  2XBV L;  4XL1 A;  2P16 L;  2WG4 B;  3BPS E;  1DIY A;  4TGF A;  2P95 L;  3K9X A;  4A7I A;  4RRX A;  1IQG L;  1CEJ A;  3N8V A;  3MQE A;  2Y81 B;  1CCV A;  3HS5 A;  1K36 A;  3FFG L;  2P26 A;  2K2T A;  1Z6E L;  3S6X A;  1MQ5 L;  1CQE A;  2YGP A;  3TK5 B;  4BTT A;  3SOQ A;  1APO A;  2VWO L;  1IQE L;  1KLI L;  1IOX A;  1IQH L;  2P93 L;  2YGQ A;  1EMO A;  3C9A C;  3LN1 A;  3ENS A;  1IQF L;  5L2Y L;  5COX A;  4XBM A;  2J2U B;  4Y79 B;  2NPR A;  2W26 B;  3KQE L;  4OTJ A;  1O5D L;  1DX5 I;  1NQL B;  2MHP A;  2Q1J B;  2BQW A;  4G1M B;  4Y71 B;  5JVY A;  1IQN L;  1COU A;  2FLR L;  2Y38 A;  5CIS A;  2F9B L;  5K0H B;  4RUT A;  2OYE P;  2VJ3 A;  4RS0 A;  1N1I A;  1EBV A;  3LTG D;  1URK A;  5CKM A;  4YZU B;  2UWL B;  2WPM E;  1HJ7 A;  2W2M E;  4D0E A;  5KIR A;  2BO2 A;  5JBA E;  3ELA L;  2FLB L;  2RNL A;  1G1T A;  1PGE A;  4NG9 L;  4CUF A;  2W3K B;  3CS7 L;  5IKQ A;  2VVU L;  2BZ6 L;  2WPK E;  1LPZ A;  2KB9 A;  1HRF A;  4ZH8 B;  2RA0 L;  2BMG A;  1G2M B;  5CKQ A;  3KQB L;  4RRY A;  4JZF L;  3HO4 A;  3V64 C;  4NGA L;  3NT1 A;  4A94 C;  2DDU A;  4RRZ A;  5JW1 A;  3GCX E;  4MMZ B;  3LN0 A;  2W3I B;  3Q7D A;  2XBX L;  3U7U G;  2BOH A;  2YGO A;  1HT5 A;  3SW2 A;  2P28 B;  1U67 A;  2VWM K;  1UZJ A;  1XDT R;  1IQK L;  3SOB B;  2BOK L;  4CUD A;  5CKN A;  2VH6 B;  4BXS A;  5IKT A;  2Y5F L;  2XC4 L;  1EZQ B;  2D1J B;  1B9W A;  5JBC E;  1ATA A;  1L3Y A;  1EQH A;  1YUG A;  2UWP B;  3LC3 B;  2EI6 B;  2XBY L;  2J95 B;  2BOX A;  1FAK L;  1A3P A;  4XLW A;  1CVW L;  2VWL L;  3HO5 A;  1L5G B;  2KL7 A;  1ATD A;  2FLG A;  1XKA L;  1P9J A;  1ATB A;  2I9B A;  2WFT A;  3BT1 A;  1ATE A;  1JBU L;  2VVV L;  1RFN B;  2VH0 B;  2Y7X B;  4Y7B B;  3R05 A;  2J34 B;  2TGF A;  1LPK A;  1Z6C A;  3TH3 L;  5FDQ A;  4JYU L;  2Y80 B;  1Q4G A;  2WZP P;  1IOE L;  4AQT A;  3OLT A;  1WU1 B;  4O1Z A;  4MMX B;  1KLO A;  2PUQ L;  1IP0 A;  1DQB A;  3GIS X;  4BXW A;  4X8T L;  1IGZ A;  5KN5 C;  3TBD A;  4E1G A;  5JVZ A;  1F7M A;  5F1A A;  1NZI A;  1EQG A;  3F6U L;  2B7D L;  2Y7Z B;  3QMO A;  3ZYI B;  2KV4 A;  2Y82 B;  2VVC K;  1YUK B;  2VWN L;  4Y76 B;  1NFX B;  5L2Z L;  1HT8 A;  1F0S B;  2BQ6 A;  1LMM A;  1U8C B;  1CX2 A;  1EPJ A;  4PH9 A;  2RHP A;  3N8W B;  5IKR A;  1FJS L;  1G1Q A;  3TZI A;  1K37 A;  4D90 A;  4NA9 L;  2K2S B;  4LOR A;  4YT7 L;  3TGF A;  3TK6 B;  4CSY A;  1P0S L;  1G2L B;  4CUE A;  3V65 B;  3LC5 B;  1LQD A;  1W7X L;  5I46 L;  2XC0 L;  3N8X A;  5JB8 E;  1WHE A;  5EGM B;  2WFX B;  1IQI L;  2H9E C;  3BT2 A;  3HPT A;  2J4I B;  4RRW A;  4Y6D B;  2WPI E;  3KRK A;  5JB9 E;  1UZK A;  1XFE A;  1J9C L;  4M10 A;  1PXX A;  4COX A;  3NTB A;  3FBY A;  2H9E L;  2ADX A;  1APQ A;  1DVA L;  3IIT B;  3MDL A;  1NFY B;  1CVU A;  1FSB A;  2GD4 A;  3N8W A;  2BOU A;  4Y7A B;  1W8B L;  4JZE L;  4C16 A;  1MOX C;  1EPG A;  1FE2 A;  1HRE A;  1OB1 C;  1LMJ A;  4BDW A;  2PHB B;  3M36 L;  2W86 A;  3NTG A;  1YUF A;  3F1S B;  4X8U L;  5IKV A;  1GK5 A;  1SZB A;  1NFW B;  2P3T A;  1JL9 A;  3ASI A;  1PFX L;  1PRH A;  2PR3 B;  2AYL A;  1TPG A;  2OYU P;  1F0R B;  1LPG A;  2M74 A;  3DEM A;  3LAQ A;  4D0F A;  4BDX A;  2EI8 B;  2W2O E;  1YO8 A;  4FM5 A;  2UWO B;  3KCG L;  4BTI A;  2KNI A;  2Y5G L;  1IJQ A;  2J38 B;  3KQC L;  3LIW B;  3QCW A;  1BF9 A;  1G1S A;  1ZAQ A;  4Z6A L;  1NPE B;  4OTY A;  3CA7 A;  1IQL L;  3CEN L;  4O02 B;  4ZXX L;  3SOV A;  1NT0 A;  3P5B L;  3LTF B;  3EGF A;  3N8Y A;  1EGF A;  1WHF A;  3FCS B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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