5L2YL

Factor viia in complex with the inhibitor 1-[(2r,15r)-2-[(1-amino-4-fluoroisoquinolin-6-yl)amino]-4,15,20-trimethyl-3,12-dioxo-13-oxa-4,11-diazatricyclo[14.2.2.1~6,10~]henicosa-1(18),6,8,10(21),16,19-hexaen-7-yl] cyclobutane-1-carboxylic acid
Total Genus 12
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
12
sequence length
55
structure length
55
Chain Sequence
ICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILEKR
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Synthesis and P1' SAR exploration of potent macrocyclic tissue factor-factor VIIa inhibitors.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Homo sapiens
molecule keywords Coagulation factor VII (Heavy Chain)
total genus 12
structure length 55
sequence length 55
ec nomenclature ec 3.4.21.21: Coagulation factor VIIa.
pdb deposition date 2016-08-02
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.25.10 Mainly Beta Ribbon Laminin Laminin 5l2yL00
4MMXB 1X7AL 1MOXC 2Y38A 3H5CB 1N7DA 2VWMK 5CISA 5JBAE 3SOVA 3NT1A 1EBVA 1K37A 1TOZA 4ZXXL 2J2UB 4G1MB 1HCGB 2Y7XB 2VVCK 3SOBB 1LPKA 2I9BA 1CCFA 2WPKE 3R05A 4LORA 3N8ZA 1G1TA 2Y81B 3CS7L 1NFYB 2XBYL 3V65B 3HPTA 5IKVA 1O5DL 2BZ6L 2ADXA 2P95L 4Y7AB 2G00L 4M11A 4ZAEB 1YUKB 4X8UL 5JVZA 2UWPB 2J94B 1PGEA 3TK5B 3FFGL 4Z0KB 3SOQA 2VJ3A 2JKHL 2BOXA 3ZYIB 5FDQA 1EPGA 2RHPA 4NG9L 1IGZA 4BXSA 1UZPA 2P93L 5KIRA 1WHEA 5JB9E 2FLBL 4BDWA 2P3UA 2BMGA 2MGPA 4AQTA 1U8CB 1ATBA 3U7UG 2W2ME 1DVAL 2MHPA 3KQCL 1ZAQA 3P5BL 1ATDA 1IQKL 3TZIA 1C5MF 3KK6A 1HT8A 1APQA 3HO4A 1NPEB 2CJIB 2FLRL 3POYA 2WFXB 1DQBA 1NQLB 1N1IA 1HREA 2KB9A 2P94L 2FZZL 3PGHA 1EQHA 3BT1A 3ENSA 1APOA 5E8DA 4XLWA 1KLIL 3KRKA 2WPLE 3HO5A 1ADXA 4M10A 1EPHA 4CUFA 5JBBE 2W3IB 4XBMA 1NT0A 2Y82B 1IQLL 1RFNB 1CVUA 1UZJA 1DIYA 2BOHA 1PFXL 3QH0A 4Y71B 1YO8A 1JBUL 2Y5GL 1IQJL 1G2MB 3N8VA 3V64C 1TLEA 2KV4A 3KQEL 3GCXE 1QFKL 1DDXA 3N8XA 1LPZA 2WYGB 4OTJA 2B7DL 3QCWA 4RUTA 1B9WA 5CKNA 2F9BL 5JBCE 2VWLL 1FAXL 2W26B 2OYEP 3KQBL 3N8WA 1Z6CA 1EPIA 3TH3L 3SW2A 2UWOB 4X8VL 4XL1A 3TBDA 1P0SL 5L2YL 4Y79B 4BTUA 1F0SB 2PR3B 5L30L 3F1SB 2Y5FL 2PHBB 1IQGL 3LN0A 4D0FA 2H9EL 4BXWA 4Y7BB 4CUDA 1MQ5L 3N8YA 1F7EA 5JW1A 2M74A 2RNLA 2W86A 2OYUP 3TK6B 2WPME 1FE2A 2BOKL 1BF9A 1PXXA 3HO3A 3FCSB 1EMOA 2WFTA 4RRWA 1WU1B 3OLTA 1IP0A 1J9CL 1IVOC 1IGXA 1XFEA 1HT5A 3N8WB 2XBVL 2J95B 2VH0B 1KLJL 2Y80B 1PRHA 3IJEB 3HS7A 1M1XB 4OTYA 1Z6EL 2WPHE 2WYJB 4Z0LA 1W7XL 3C9AC 2Y5HL 3LIWB 2PUQL 4Y6DB 4E1GA 3N8YB 3GISX 1ATEA 1KLOA 4CUEA 2XC5L 1OB1C 3BPSE 3CENL 1IQNL 3LC5B 2BOUA 2DDUA 2BO2A 1DX5I 5F19A 1FSBA 1YUGA 2D1JB 3FBYA 3KL6B 4RRXA 4O02B 1IQHL 3Q3KB 5IKRA 2MGRA 1YGCL 3LC3B 4MMZB 3U73A 2W2QE 1FF7A 2NPRA 1FAKL 5K0HB 4RRZA 1FFMA 1HX2A 1A3PA 2VWOL 3M37L 3KQDL 3MQEA 1EMNA 1WHFA 2EI6B 2KL7A 1U67A 1LMJA 1IJQA 3EGFA 1L5GB 1Q4GA 1F0RB 2XC4L 5KN5C 1EAIC 3F6UL 1IQML 2BQWA 4Y76B 1XKBA 3GCWE 5JVYA 2EI7B 2WG3C 4YT6L 3Q7DA 4YT7L 1EGFA 3CFWA 3TGFA 2VVVL 1ATAA 4RS0A 5CKMA 4X8TL 1SZBA 4NA9L 1G1QA 2AYLA 4YZUB 1NZIA 3RR3A 1HRFA 1G1SA 1G1RA 2XC0L 1IOEL 1NFWB 2TGFA 4ISHL 4RRYA 4BDXA 1KSNB 4NGAL 1HJ7A 3IITB 3BT2A 2P3FN 2W3KB 2UWLB 1XKAL 2W2OE 3QMOA 5CKQA 2W2NE 4TGFA 1XDTR 2GD4A 3HS5A 1CQEA 1TPGA 2YGOA 2RA0L 1EZQB 2K2TA 2YGPA 1JV2B 4MMYB 2WG4B 2P16L 1MQ6L 1KIGL 4D0EA 3DEMA 3NTBA 1GK5A 4BTTA 3HS6A 4BTIA 5IKTA 2J38B 3CA7A 1UZKA 2WPJE 1EQGA 1JL9A 2FLGA 1CX2A 3LAQA 2EI8B 4Z6AL 1FJSL 2Y7ZB 4JZFL 4PH9A 3OLUA 1IQIL 1HAEA 1HAFA 1LPGA 1LQDA 3ELAL 2BQ6A 2I9AA 1L3YA 1I0UA 1NFUB 1EPJA 1PTHA 4X8SL 4D90A 2P3TA 1UZQA 1IOXA 2WPIE 1V3XB 3LTFB 3NJPC 1G2LB 3KCGL 5F1AA 2J4IB 2J34B 3LTGD 4ZHAB 2P26A 3ZYGA 4FM5A 1F7MA 1K36A 1HZ8A 1IQEL 5COXA 3MDLA 4JYUL 2K2SB 3ASIA 3M36L 4JYVL 2P28B 4JZEL 4CSYA 4A7IA 1CEJA 3ZYJB 5IKQA 1CCVA 3K9XA 1COUA 5I46L 4LMFA 2XBXL 4ISIL 1P9JA 2Q1JB 2VWNL 5JB8E 1URKA 2P3FL 2BQ7A 2XBWL 5EGMB 1YUFA 4ZXYL 5L2ZL 2VH6B 6COXA 2VVUL 1NFXB 1W8BL 1AUTL 4JZDL 4ZH8B 1IQFL 2W2PE 4COXA 3LN1A 3NTGA 4C16A 1CVWL 4O1ZA 2FD6A
chains in the Genus database with same CATH superfamily
4MMXB 1X7AL 1MOXC 2Y38A 3H5CB 1N7DA 2VWMK 5CISA 5JBAE 3SOVA 2HORA 3NT1A 1EBVA 1K37A 1TOZA 4ZXXL 2J2UB 4G1MB 1HCGB 2Y7XB 2VVCK 3SOBB 1LPKA 2I9BA 1CCFA 2WPKE 3R05A 4LORA 3N8ZA 1G1TA 2Y81B 3CS7L 1NFYB 2XBYL 3V65B 3HPTA 5IKVA 1O5DL 2BZ6L 2ADXA 2P95L 4Y7AB 2G00L 4M11A 4ZAEB 1YUKB 4X8UL 5JVZA 2UWPB 2J94B 1PGEA 3TK5B 3FFGL 4Z0KB 3SOQA 2VJ3A 2JKHL 2BOXA 3ZYIB 5FDQA 1EPGA 2RHPA 4NG9L 1IGZA 4BXSA 1UZPA 2P93L 5KIRA 1WHEA 5JB9E 2FLBL 1KKEA 4BDWA 2P3UA 2BMGA 2MGPA 4AQTA 1U8CB 1ATBA 3U7UG 2W2ME 1DVAL 2MHPA 3KQCL 1ZAQA 3P5BL 1ATDA 1V1IA 1IQKL 2BT8A 3TZIA 1C5MF 3KK6A 1HT8A 1APQA 3HO4A 1NPEB 2CJIB 2FLRL 3POYA 2WFXB 1DQBA 1NQLB 1N1IA 1HREA 2KB9A 2P94L 2FZZL 3PGHA 1EQHA 3BT1A 3ENSA 1APOA 5E8DA 4XLWA 1KLIL 4GU4A 3KRKA 2WPLE 3HO5A 1ADXA 4M10A 1EPHA 4CUFA 5JBBE 2W3IB 4XBMA 1NT0A 2Y82B 1IQLL 1RFNB 1CVUA 1UZJA 1DIYA 2BOHA 1PFXL 3QH0A 4Y71B 1YO8A 4GU3A 1JBUL 2Y5GL 1IQJL 1G2MB 3N8VA 3V64C 1TLEA 2KV4A 3KQEL 3GCXE 1QFKL 1DDXA 3N8XA 1LPZA 2WYGB 4OTJA 2B7DL 3QCWA 4RUTA 1B9WA 5CKNA 2F9BL 5JBCE 2VWLL 1FAXL 2W26B 2OYEP 3KQBL 3N8WA 1Z6CA 1EPIA 3TH3L 3SW2A 2UWOB 4X8VL 4XL1A 3TBDA 1P0SL 5L2YL 4Y79B 4BTUA 1F0SB 2PR3B 5L30L 3F1SB 2Y5FL 2PHBB 1IQGL 3LN0A 4D0FA 2H9EL 4BXWA 4Y7BB 4CUDA 1MQ5L 3N8YA 1F7EA 5JW1A 2M74A 2RNLA 2W86A 2OYUP 3TK6B 2WPME 2BT7A 1FE2A 2BOKL 1BF9A 1PXXA 3HO3A 3FCSB 1EMOA 2WFTA 4RRWA 1WU1B 3OLTA 1IP0A 1J9CL 1IVOC 1IGXA 1XFEA 1HT5A 3N8WB 2XBVL 1LMMA 2J95B 2VH0B 1KLJL 2Y80B 1PRHA 3IJEB 3HS7A 1M1XB 4OTYA 1Z6EL 2WPHE 2WYJB 4Z0LA 1W7XL 3C9AC 2Y5HL 3LIWB 2PUQL 4Y6DB 4E1GA 3N8YB 3GISX 1ATEA 1KLOA 4CUEA 2XC5L 1OB1C 3BPSE 3CENL 1IQNL 3LC5B 2BOUA 2VRSA 2DDUA 2BO2A 1DX5I 5F19A 2JJLA 1FSBA 1YUGA 2D1JB 3FBYA 3KL6B 4RRXA 4O02B 1IQHL 3Q3KB 5IKRA 2MGRA 2WZPP 1YGCL 3LC3B 4MMZB 3U73A 2W2QE 1FF7A 2NPRA 1FAKL 5K0HB 4RRZA 1FFMA 1HX2A 1A3PA 2VWOL 3M37L 3KQDL 3MQEA 1EMNA 1WHFA 2EI6B 2KL7A 1U67A 1QIUA 1LMJA 1IJQA 3EGFA 1L5GB 2KNIA 1Q4GA 1F0RB 2XC4L 5KN5C 1EAIC 3F6UL 1IQML 2BQWA 4Y76B 1XKBA 3GCWE 5JVYA 2EI7B 2WG3C 4YT6L 3Q7DA 4YT7L 1EGFA 3CFWA 3TGFA 2VVVL 1ATAA 4RS0A 5CKMA 4X8TL 1SZBA 4NA9L 1G1QA 2AYLA 4YZUB 1NZIA 3RR3A 1HRFA 1G1SA 1G1RA 2XC0L 1IOEL 1NFWB 2TGFA 2BSFA 4ISHL 4RRYA 4BDXA 1KSNB 4NGAL 1HJ7A 3IITB 3BT2A 2P3FN 2W3KB 2UWLB 1XKAL 2W2OE 3QMOA 5CKQA 2W2NE 4TGFA 1XDTR 2GD4A 3HS5A 1CQEA 1TPGA 2YGOA 2RA0L 1EZQB 2K2TA 2YGPA 1JV2B 4MMYB 2WG4B 2P16L 1MQ6L 1KIGL 4D0EA 3DEMA 3NTBA 1GK5A 4BTTA 3HS6A 4BTIA 5IKTA 2J38B 3CA7A 1UZKA 2WPJE 1EQGA 1JL9A 2FLGA 1CX2A 3LAQA 2EI8B 4Z6AL 1FJSL 2Y7ZB 4JZFL 4PH9A 3OLUA 1IQIL 1HAEA 3S6XA 1HAFA 1LPGA 1LQDA 3ELAL 2BQ6A 2I9AA 1L3YA 1I0UA 2YGQA 1NFUB 1EPJA 1PTHA 4X8SL 4A94C 4D90A 2P3TA 1UZQA 1IOXA 1LK9A 2WPIE 1V3XB 3LTFB 3NJPC 1G2LB 3KCGL 5F1AA 2J4IB 2J34B 3LTGD 4ZHAB 2P26A 1V1HA 3ZYGA 4FM5A 1F7MA 1K36A 1HZ8A 1IQEL 5COXA 3MDLA 4JYUL 2K2SB 3ASIA 3M36L 4JYVL 2P28B 4JZEL 4CSYA 4A7IA 1CEJA 2H9EC 3ZYJB 5IKQA 1CCVA 3K9XA 1COUA 5I46L 4LMFA 2XBXL 4ISIL 1P9JA 2Q1JB 2VWNL 5JB8E 1URKA 2P3FL 2BQ7A 2XBWL 2HOXA 5EGMB 1YUFA 4ZXYL 5L2ZL 2VH6B 6COXA 2VVUL 1NFXB 1W8BL 1AUTL 4JZDL 4ZH8B 1IQFL 2W2PE 4COXA 3LN1A 3NTGA 4C16A 1CVWL 4O1ZA 2FD6A
chains in the Genus database with same CATH topology
4MMXB 1X7AL 1MOXC 2Y38A 3H5CB 1N7DA 2VWMK 5CISA 5JBAE 3SOVA 3NT1A 1EBVA 1K37A 1TOZA 4ZXXL 2J2UB 4G1MB 1HCGB 2Y7XB 2VVCK 3SOBB 1LPKA 2I9BA 1CCFA 2WPKE 3R05A 4LORA 3N8ZA 1G1TA 2Y81B 3CS7L 1NFYB 2XBYL 3V65B 3HPTA 5IKVA 1O5DL 2BZ6L 2ADXA 2P95L 4Y7AB 2G00L 4M11A 4ZAEB 1YUKB 4X8UL 5JVZA 2UWPB 2J94B 1PGEA 3TK5B 3FFGL 4Z0KB 3SOQA 2VJ3A 2JKHL 2BOXA 3ZYIB 5FDQA 1EPGA 2RHPA 4NG9L 1IGZA 4BXSA 1UZPA 2P93L 5KIRA 1WHEA 5JB9E 2FLBL 4BDWA 2P3UA 2BMGA 2MGPA 4AQTA 1U8CB 1ATBA 3U7UG 2W2ME 1DVAL 2MHPA 3KQCL 1ZAQA 3P5BL 1ATDA 1IQKL 3TZIA 1C5MF 3KK6A 1HT8A 1APQA 3HO4A 1NPEB 2CJIB 2FLRL 3POYA 2WFXB 1DQBA 1NQLB 1N1IA 1HREA 2KB9A 2P94L 2FZZL 3PGHA 1EQHA 3BT1A 3ENSA 1APOA 5E8DA 4XLWA 1KLIL 3KRKA 2WPLE 3HO5A 1ADXA 4M10A 1EPHA 4CUFA 5JBBE 2W3IB 4XBMA 1NT0A 2Y82B 1IQLL 1RFNB 1CVUA 1UZJA 1DIYA 2BOHA 1PFXL 3QH0A 4Y71B 1YO8A 1JBUL 2Y5GL 1IQJL 1G2MB 3N8VA 3V64C 1TLEA 2KV4A 3KQEL 3GCXE 1QFKL 1DDXA 3N8XA 1LPZA 2WYGB 4OTJA 2B7DL 3QCWA 4RUTA 1B9WA 5CKNA 2F9BL 5JBCE 2VWLL 1FAXL 2W26B 2OYEP 3KQBL 3N8WA 1Z6CA 1EPIA 3TH3L 3SW2A 2UWOB 4X8VL 4XL1A 3TBDA 1P0SL 5L2YL 4Y79B 4BTUA 1F0SB 2PR3B 5L30L 3F1SB 2Y5FL 2PHBB 1IQGL 3LN0A 4D0FA 2H9EL 4BXWA 4Y7BB 4CUDA 1MQ5L 3N8YA 1F7EA 5JW1A 2M74A 2RNLA 2W86A 2OYUP 3TK6B 2WPME 1FE2A 2BOKL 1BF9A 1PXXA 3HO3A 3FCSB 1EMOA 2WFTA 4RRWA 1WU1B 3OLTA 1IP0A 1J9CL 1IVOC 1IGXA 1XFEA 1HT5A 3N8WB 2XBVL 1LMMA 2J95B 2VH0B 1KLJL 2Y80B 1PRHA 3IJEB 3HS7A 1M1XB 4OTYA 1Z6EL 2WPHE 2WYJB 4Z0LA 1W7XL 3C9AC 2Y5HL 3LIWB 2PUQL 4Y6DB 4E1GA 3N8YB 3GISX 1ATEA 1KLOA 4CUEA 2XC5L 1OB1C 3BPSE 3CENL 1IQNL 3LC5B 2BOUA 2DDUA 2BO2A 1DX5I 5F19A 1FSBA 1YUGA 2D1JB 3FBYA 3KL6B 4RRXA 4O02B 1IQHL 3Q3KB 5IKRA 2MGRA 2WZPP 1YGCL 3LC3B 4MMZB 3U73A 2W2QE 1FF7A 2NPRA 1FAKL 5K0HB 4RRZA 1FFMA 1HX2A 1A3PA 2VWOL 3M37L 3KQDL 3MQEA 1EMNA 1WHFA 2EI6B 2KL7A 1U67A 1LMJA 1IJQA 3EGFA 1L5GB 2KNIA 1Q4GA 1F0RB 2XC4L 5KN5C 1EAIC 3F6UL 1IQML 2BQWA 4Y76B 1XKBA 3GCWE 5JVYA 2EI7B 2WG3C 4YT6L 3Q7DA 4YT7L 1EGFA 3CFWA 3TGFA 2VVVL 1ATAA 4RS0A 5CKMA 4X8TL 1SZBA 4NA9L 1G1QA 2AYLA 4YZUB 1NZIA 3RR3A 1HRFA 1G1SA 1G1RA 2XC0L 1IOEL 1NFWB 2TGFA 4ISHL 4RRYA 4BDXA 1KSNB 4NGAL 1HJ7A 3IITB 3BT2A 2P3FN 2W3KB 2UWLB 1XKAL 2W2OE 3QMOA 5CKQA 2W2NE 4TGFA 1XDTR 2GD4A 3HS5A 1CQEA 1TPGA 2YGOA 2RA0L 1EZQB 2K2TA 2YGPA 1JV2B 4MMYB 2WG4B 2P16L 1MQ6L 1KIGL 4D0EA 3DEMA 3NTBA 1GK5A 4BTTA 3HS6A 4BTIA 5IKTA 2J38B 3CA7A 1UZKA 2WPJE 1EQGA 1JL9A 2FLGA 1CX2A 3LAQA 2EI8B 4Z6AL 1FJSL 2Y7ZB 4JZFL 4PH9A 3OLUA 1IQIL 1HAEA 3S6XA 1HAFA 1LPGA 1LQDA 3ELAL 2BQ6A 2I9AA 1L3YA 1I0UA 2YGQA 1NFUB 1EPJA 1PTHA 4X8SL 4A94C 4D90A 2P3TA 1UZQA 1IOXA 2WPIE 1V3XB 3LTFB 3NJPC 1G2LB 3KCGL 5F1AA 2J4IB 2J34B 3LTGD 4ZHAB 2P26A 3ZYGA 4FM5A 1F7MA 1K36A 1HZ8A 1IQEL 5COXA 3MDLA 4JYUL 2K2SB 3ASIA 3M36L 4JYVL 2P28B 4JZEL 4CSYA 4A7IA 1CEJA 2H9EC 3ZYJB 5IKQA 1CCVA 3K9XA 1COUA 5I46L 4LMFA 2XBXL 4ISIL 1P9JA 2Q1JB 2VWNL 5JB8E 1URKA 2P3FL 2BQ7A 2XBWL 5EGMB 1YUFA 4ZXYL 5L2ZL 2VH6B 6COXA 2VVUL 1NFXB 1W8BL 1AUTL 4JZDL 4ZH8B 1IQFL 2W2PE 4COXA 3LN1A 3NTGA 4C16A 1CVWL 4O1ZA 2FD6A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4MMX B;  1X7A L;  1MOX C;  2Y38 A;  3H5C B;  1N7D A;  2VWM K;  5CIS A;  5JBA E;  3SOV A;  3NT1 A;  1EBV A;  1K37 A;  1TOZ A;  4ZXX L;  2J2U B;  4G1M B;  1HCG B;  2Y7X B;  2VVC K;  3SOB B;  1LPK A;  2I9B A;  1CCF A;  2WPK E;  3R05 A;  4LOR A;  3N8Z A;  1G1T A;  2Y81 B;  3CS7 L;  1NFY B;  2XBY L;  3V65 B;  3HPT A;  5IKV A;  1O5D L;  2BZ6 L;  2ADX A;  2P95 L;  4Y7A B;  2G00 L;  4M11 A;  4ZAE B;  1YUK B;  4X8U L;  5JVZ A;  2UWP B;  2J94 B;  1PGE A;  3TK5 B;  3FFG L;  4Z0K B;  3SOQ A;  2VJ3 A;  2JKH L;  2BOX A;  3ZYI B;  5FDQ A;  1EPG A;  2RHP A;  4NG9 L;  1IGZ A;  4BXS A;  1UZP A;  2P93 L;  5KIR A;  1WHE A;  5JB9 E;  2FLB L;  4BDW A;  2P3U A;  2BMG A;  2MGP A;  4AQT A;  1U8C B;  1ATB A;  3U7U G;  2W2M E;  1DVA L;  2MHP A;  3KQC L;  1ZAQ A;  3P5B L;  1ATD A;  1IQK L;  3TZI A;  1C5M F;  3KK6 A;  1HT8 A;  1APQ A;  3HO4 A;  1NPE B;  2CJI B;  2FLR L;  3POY A;  2WFX B;  1DQB A;  1NQL B;  1N1I A;  1HRE A;  2KB9 A;  2P94 L;  2FZZ L;  3PGH A;  1EQH A;  3BT1 A;  3ENS A;  1APO A;  5E8D A;  4XLW A;  1KLI L;  3KRK A;  2WPL E;  3HO5 A;  1ADX A;  4M10 A;  1EPH A;  4CUF A;  5JBB E;  2W3I B;  4XBM A;  1NT0 A;  2Y82 B;  1IQL L;  1RFN B;  1CVU A;  1UZJ A;  1DIY A;  2BOH A;  1PFX L;  3QH0 A;  4Y71 B;  1YO8 A;  1JBU L;  2Y5G L;  1IQJ L;  1G2M B;  3N8V A;  3V64 C;  1TLE A;  2KV4 A;  3KQE L;  3GCX E;  1QFK L;  1DDX A;  3N8X A;  1LPZ A;  2WYG B;  4OTJ A;  2B7D L;  3QCW A;  4RUT A;  1B9W A;  5CKN A;  2F9B L;  5JBC E;  2VWL L;  1FAX L;  2W26 B;  2OYE P;  3KQB L;  3N8W A;  1Z6C A;  1EPI A;  3TH3 L;  3SW2 A;  2UWO B;  4X8V L;  4XL1 A;  3TBD A;  1P0S L;  5L2Y L;  4Y79 B;  4BTU A;  1F0S B;  2PR3 B;  5L30 L;  3F1S B;  2Y5F L;  2PHB B;  1IQG L;  3LN0 A;  4D0F A;  2H9E L;  4BXW A;  4Y7B B;  4CUD A;  1MQ5 L;  3N8Y A;  1F7E A;  5JW1 A;  2M74 A;  2RNL A;  2W86 A;  2OYU P;  3TK6 B;  2WPM E;  1FE2 A;  2BOK L;  1BF9 A;  1PXX A;  3HO3 A;  3FCS B;  1EMO A;  2WFT A;  4RRW A;  1WU1 B;  3OLT A;  1IP0 A;  1J9C L;  1IVO C;  1IGX A;  1XFE A;  1HT5 A;  3N8W B;  2XBV L;  2J95 B;  2VH0 B;  1KLJ L;  2Y80 B;  1PRH A;  3IJE B;  3HS7 A;  1M1X B;  4OTY A;  1Z6E L;  2WPH E;  2WYJ B;  4Z0L A;  1W7X L;  3C9A C;  2Y5H L;  3LIW B;  2PUQ L;  4Y6D B;  4E1G A;  3N8Y B;  3GIS X;  1ATE A;  1KLO A;  4CUE A;  2XC5 L;  1OB1 C;  3BPS E;  3CEN L;  1IQN L;  3LC5 B;  2BOU A;  2DDU A;  2BO2 A;  1DX5 I;  5F19 A;  1FSB A;  1YUG A;  2D1J B;  3FBY A;  3KL6 B;  4RRX A;  4O02 B;  1IQH L;  3Q3K B;  5IKR A;  2MGR A;  1YGC L;  3LC3 B;  4MMZ B;  3U73 A;  2W2Q E;  1FF7 A;  2NPR A;  1FAK L;  5K0H B;  4RRZ A;  1FFM A;  1HX2 A;  1A3P A;  2VWO L;  3M37 L;  3KQD L;  3MQE A;  1EMN A;  1WHF A;  2EI6 B;  2KL7 A;  1U67 A;  1LMJ A;  1IJQ A;  3EGF A;  1L5G B;  1Q4G A;  1F0R B;  2XC4 L;  5KN5 C;  1EAI C;  3F6U L;  1IQM L;  2BQW A;  4Y76 B;  1XKB A;  3GCW E;  5JVY A;  2EI7 B;  2WG3 C;  4YT6 L;  3Q7D A;  4YT7 L;  1EGF A;  3CFW A;  3TGF A;  2VVV L;  1ATA A;  4RS0 A;  5CKM A;  4X8T L;  1SZB A;  4NA9 L;  1G1Q A;  2AYL A;  4YZU B;  1NZI A;  3RR3 A;  1HRF A;  1G1S A;  1G1R A;  2XC0 L;  1IOE L;  1NFW B;  2TGF A;  4ISH L;  4RRY A;  4BDX A;  1KSN B;  4NGA L;  1HJ7 A;  3IIT B;  3BT2 A;  2P3F N;  2W3K B;  2UWL B;  1XKA L;  2W2O E;  3QMO A;  5CKQ A;  2W2N E;  4TGF A;  1XDT R;  2GD4 A;  3HS5 A;  1CQE A;  1TPG A;  2YGO A;  2RA0 L;  1EZQ B;  2K2T A;  2YGP A;  1JV2 B;  4MMY B;  2WG4 B;  2P16 L;  1MQ6 L;  1KIG L;  4D0E A;  3DEM A;  3NTB A;  1GK5 A;  4BTT A;  3HS6 A;  4BTI A;  5IKT A;  2J38 B;  3CA7 A;  1UZK A;  2WPJ E;  1EQG A;  1JL9 A;  2FLG A;  1CX2 A;  3LAQ A;  2EI8 B;  4Z6A L;  1FJS L;  2Y7Z B;  4JZF L;  4PH9 A;  3OLU A;  1IQI L;  1HAE A;  1HAF A;  1LPG A;  1LQD A;  3ELA L;  2BQ6 A;  2I9A A;  1L3Y A;  1I0U A;  1NFU B;  1EPJ A;  1PTH A;  4X8S L;  4D90 A;  2P3T A;  1UZQ A;  1IOX A;  2WPI E;  1V3X B;  3LTF B;  3NJP C;  1G2L B;  3KCG L;  5F1A A;  2J4I B;  2J34 B;  3LTG D;  4ZHA B;  2P26 A;  3ZYG A;  4FM5 A;  1F7M A;  1K36 A;  1HZ8 A;  1IQE L;  5COX A;  3MDL A;  4JYU L;  2K2S B;  3ASI A;  3M36 L;  4JYV L;  2P28 B;  4JZE L;  4CSY A;  4A7I A;  1CEJ A;  3ZYJ B;  5IKQ A;  1CCV A;  3K9X A;  1COU A;  5I46 L;  4LMF A;  2XBX L;  4ISI L;  1P9J A;  2Q1J B;  2VWN L;  5JB8 E;  1URK A;  2P3F L;  2BQ7 A;  2XBW L;  5EGM B;  1YUF A;  4ZXY L;  5L2Z L;  2VH6 B;  6COX A;  2VVU L;  1NFX B;  1W8B L;  1AUT L;  4JZD L;  4ZH8 B;  1IQF L;  2W2P E;  4COX A;  3LN1 A;  3NTG A;  4C16 A;  1CVW L;  4O1Z A;  2FD6 A; 
#chains in the Genus database with same CATH topology
 4MMX B;  1X7A L;  1MOX C;  2Y38 A;  3H5C B;  1N7D A;  2VWM K;  5CIS A;  5JBA E;  3SOV A;  2HOR A;  3NT1 A;  1EBV A;  1K37 A;  1TOZ A;  4ZXX L;  2J2U B;  4G1M B;  1HCG B;  2Y7X B;  2VVC K;  3SOB B;  1LPK A;  2I9B A;  1CCF A;  2WPK E;  3R05 A;  4LOR A;  3N8Z A;  1G1T A;  2Y81 B;  3CS7 L;  1NFY B;  2XBY L;  3V65 B;  3HPT A;  5IKV A;  1O5D L;  2BZ6 L;  2ADX A;  2P95 L;  4Y7A B;  2G00 L;  4M11 A;  4ZAE B;  1YUK B;  4X8U L;  5JVZ A;  2UWP B;  2J94 B;  1PGE A;  3TK5 B;  3FFG L;  4Z0K B;  3SOQ A;  2VJ3 A;  2JKH L;  2BOX A;  3ZYI B;  5FDQ A;  1EPG A;  2RHP A;  4NG9 L;  1IGZ A;  4BXS A;  1UZP A;  2P93 L;  5KIR A;  1WHE A;  5JB9 E;  2FLB L;  1KKE A;  4BDW A;  2P3U A;  2BMG A;  2MGP A;  4AQT A;  1U8C B;  1ATB A;  3U7U G;  2W2M E;  1DVA L;  2MHP A;  3KQC L;  1ZAQ A;  3P5B L;  1ATD A;  1V1I A;  1IQK L;  2BT8 A;  3TZI A;  1C5M F;  3KK6 A;  1HT8 A;  1APQ A;  3HO4 A;  1NPE B;  2CJI B;  2FLR L;  3POY A;  2WFX B;  1DQB A;  1NQL B;  1N1I A;  1HRE A;  2KB9 A;  2P94 L;  2FZZ L;  3PGH A;  1EQH A;  3BT1 A;  3ENS A;  1APO A;  5E8D A;  4XLW A;  1KLI L;  4GU4 A;  3KRK A;  2WPL E;  3HO5 A;  1ADX A;  4M10 A;  1EPH A;  4CUF A;  5JBB E;  2W3I B;  4XBM A;  1NT0 A;  2Y82 B;  1IQL L;  1RFN B;  1CVU A;  1UZJ A;  1DIY A;  2BOH A;  1PFX L;  3QH0 A;  4Y71 B;  1YO8 A;  4GU3 A;  1JBU L;  2Y5G L;  1IQJ L;  1G2M B;  3N8V A;  3V64 C;  1TLE A;  2KV4 A;  3KQE L;  3GCX E;  1QFK L;  1DDX A;  3N8X A;  1LPZ A;  2WYG B;  4OTJ A;  2B7D L;  3QCW A;  4RUT A;  1B9W A;  5CKN A;  2F9B L;  5JBC E;  2VWL L;  1FAX L;  2W26 B;  2OYE P;  3KQB L;  3N8W A;  1Z6C A;  1EPI A;  3TH3 L;  3SW2 A;  2UWO B;  4X8V L;  4XL1 A;  3TBD A;  1P0S L;  5L2Y L;  4Y79 B;  4BTU A;  1F0S B;  2PR3 B;  5L30 L;  3F1S B;  2Y5F L;  2PHB B;  1IQG L;  3LN0 A;  4D0F A;  2H9E L;  4BXW A;  4Y7B B;  4CUD A;  1MQ5 L;  3N8Y A;  1F7E A;  5JW1 A;  2M74 A;  2RNL A;  2W86 A;  2OYU P;  3TK6 B;  2WPM E;  2BT7 A;  1FE2 A;  2BOK L;  1BF9 A;  1PXX A;  3HO3 A;  3FCS B;  1EMO A;  2WFT A;  4RRW A;  1WU1 B;  3OLT A;  1IP0 A;  1J9C L;  1IVO C;  1IGX A;  1XFE A;  1HT5 A;  3N8W B;  2XBV L;  1LMM A;  2J95 B;  2VH0 B;  1KLJ L;  2Y80 B;  1PRH A;  3IJE B;  3HS7 A;  1M1X B;  4OTY A;  1Z6E L;  2WPH E;  2WYJ B;  4Z0L A;  1W7X L;  3C9A C;  2Y5H L;  3LIW B;  2PUQ L;  4Y6D B;  4E1G A;  3N8Y B;  3GIS X;  1ATE A;  1KLO A;  4CUE A;  2XC5 L;  1OB1 C;  3BPS E;  3CEN L;  1IQN L;  3LC5 B;  2BOU A;  2VRS A;  2DDU A;  2BO2 A;  1DX5 I;  5F19 A;  2JJL A;  1FSB A;  1YUG A;  2D1J B;  3FBY A;  3KL6 B;  4RRX A;  4O02 B;  1IQH L;  3Q3K B;  5IKR A;  2MGR A;  2WZP P;  1YGC L;  3LC3 B;  4MMZ B;  3U73 A;  2W2Q E;  1FF7 A;  2NPR A;  1FAK L;  5K0H B;  4RRZ A;  1FFM A;  1HX2 A;  1A3P A;  2VWO L;  3M37 L;  3KQD L;  3MQE A;  1EMN A;  1WHF A;  2EI6 B;  2KL7 A;  1U67 A;  1QIU A;  1LMJ A;  1IJQ A;  3EGF A;  1L5G B;  2KNI A;  1Q4G A;  1F0R B;  2XC4 L;  5KN5 C;  1EAI C;  3F6U L;  1IQM L;  2BQW A;  4Y76 B;  1XKB A;  3GCW E;  5JVY A;  2EI7 B;  2WG3 C;  4YT6 L;  3Q7D A;  4YT7 L;  1EGF A;  3CFW A;  3TGF A;  2VVV L;  1ATA A;  4RS0 A;  5CKM A;  4X8T L;  1SZB A;  4NA9 L;  1G1Q A;  2AYL A;  4YZU B;  1NZI A;  3RR3 A;  1HRF A;  1G1S A;  1G1R A;  2XC0 L;  1IOE L;  1NFW B;  2TGF A;  2BSF A;  4ISH L;  4RRY A;  4BDX A;  1KSN B;  4NGA L;  1HJ7 A;  3IIT B;  3BT2 A;  2P3F N;  2W3K B;  2UWL B;  1XKA L;  2W2O E;  3QMO A;  5CKQ A;  2W2N E;  4TGF A;  1XDT R;  2GD4 A;  3HS5 A;  1CQE A;  1TPG A;  2YGO A;  2RA0 L;  1EZQ B;  2K2T A;  2YGP A;  1JV2 B;  4MMY B;  2WG4 B;  2P16 L;  1MQ6 L;  1KIG L;  4D0E A;  3DEM A;  3NTB A;  1GK5 A;  4BTT A;  3HS6 A;  4BTI A;  5IKT A;  2J38 B;  3CA7 A;  1UZK A;  2WPJ E;  1EQG A;  1JL9 A;  2FLG A;  1CX2 A;  3LAQ A;  2EI8 B;  4Z6A L;  1FJS L;  2Y7Z B;  4JZF L;  4PH9 A;  3OLU A;  1IQI L;  1HAE A;  3S6X A;  1HAF A;  1LPG A;  1LQD A;  3ELA L;  2BQ6 A;  2I9A A;  1L3Y A;  1I0U A;  2YGQ A;  1NFU B;  1EPJ A;  1PTH A;  4X8S L;  4A94 C;  4D90 A;  2P3T A;  1UZQ A;  1IOX A;  1LK9 A;  2WPI E;  1V3X B;  3LTF B;  3NJP C;  1G2L B;  3KCG L;  5F1A A;  2J4I B;  2J34 B;  3LTG D;  4ZHA B;  2P26 A;  1V1H A;  3ZYG A;  4FM5 A;  1F7M A;  1K36 A;  1HZ8 A;  1IQE L;  5COX A;  3MDL A;  4JYU L;  2K2S B;  3ASI A;  3M36 L;  4JYV L;  2P28 B;  4JZE L;  4CSY A;  4A7I A;  1CEJ A;  2H9E C;  3ZYJ B;  5IKQ A;  1CCV A;  3K9X A;  1COU A;  5I46 L;  4LMF A;  2XBX L;  4ISI L;  1P9J A;  2Q1J B;  2VWN L;  5JB8 E;  1URK A;  2P3F L;  2BQ7 A;  2XBW L;  2HOX A;  5EGM B;  1YUF A;  4ZXY L;  5L2Z L;  2VH6 B;  6COX A;  2VVU L;  1NFX B;  1W8B L;  1AUT L;  4JZD L;  4ZH8 B;  1IQF L;  2W2P E;  4COX A;  3LN1 A;  3NTG A;  4C16 A;  1CVW L;  4O1Z A;  2FD6 A; 
#chains in the Genus database with same CATH homology
 4MMX B;  1X7A L;  1MOX C;  2Y38 A;  3H5C B;  1N7D A;  2VWM K;  5CIS A;  5JBA E;  3SOV A;  3NT1 A;  1EBV A;  1K37 A;  1TOZ A;  4ZXX L;  2J2U B;  4G1M B;  1HCG B;  2Y7X B;  2VVC K;  3SOB B;  1LPK A;  2I9B A;  1CCF A;  2WPK E;  3R05 A;  4LOR A;  3N8Z A;  1G1T A;  2Y81 B;  3CS7 L;  1NFY B;  2XBY L;  3V65 B;  3HPT A;  5IKV A;  1O5D L;  2BZ6 L;  2ADX A;  2P95 L;  4Y7A B;  2G00 L;  4M11 A;  4ZAE B;  1YUK B;  4X8U L;  5JVZ A;  2UWP B;  2J94 B;  1PGE A;  3TK5 B;  3FFG L;  4Z0K B;  3SOQ A;  2VJ3 A;  2JKH L;  2BOX A;  3ZYI B;  5FDQ A;  1EPG A;  2RHP A;  4NG9 L;  1IGZ A;  4BXS A;  1UZP A;  2P93 L;  5KIR A;  1WHE A;  5JB9 E;  2FLB L;  4BDW A;  2P3U A;  2BMG A;  2MGP A;  4AQT A;  1U8C B;  1ATB A;  3U7U G;  2W2M E;  1DVA L;  2MHP A;  3KQC L;  1ZAQ A;  3P5B L;  1ATD A;  1IQK L;  3TZI A;  1C5M F;  3KK6 A;  1HT8 A;  1APQ A;  3HO4 A;  1NPE B;  2CJI B;  2FLR L;  3POY A;  2WFX B;  1DQB A;  1NQL B;  1N1I A;  1HRE A;  2KB9 A;  2P94 L;  2FZZ L;  3PGH A;  1EQH A;  3BT1 A;  3ENS A;  1APO A;  5E8D A;  4XLW A;  1KLI L;  3KRK A;  2WPL E;  3HO5 A;  1ADX A;  4M10 A;  1EPH A;  4CUF A;  5JBB E;  2W3I B;  4XBM A;  1NT0 A;  2Y82 B;  1IQL L;  1RFN B;  1CVU A;  1UZJ A;  1DIY A;  2BOH A;  1PFX L;  3QH0 A;  4Y71 B;  1YO8 A;  1JBU L;  2Y5G L;  1IQJ L;  1G2M B;  3N8V A;  3V64 C;  1TLE A;  2KV4 A;  3KQE L;  3GCX E;  1QFK L;  1DDX A;  3N8X A;  1LPZ A;  2WYG B;  4OTJ A;  2B7D L;  3QCW A;  4RUT A;  1B9W A;  5CKN A;  2F9B L;  5JBC E;  2VWL L;  1FAX L;  2W26 B;  2OYE P;  3KQB L;  3N8W A;  1Z6C A;  1EPI A;  3TH3 L;  3SW2 A;  2UWO B;  4X8V L;  4XL1 A;  3TBD A;  1P0S L;  5L2Y L;  4Y79 B;  4BTU A;  1F0S B;  2PR3 B;  5L30 L;  3F1S B;  2Y5F L;  2PHB B;  1IQG L;  3LN0 A;  4D0F A;  2H9E L;  4BXW A;  4Y7B B;  4CUD A;  1MQ5 L;  3N8Y A;  1F7E A;  5JW1 A;  2M74 A;  2RNL A;  2W86 A;  2OYU P;  3TK6 B;  2WPM E;  1FE2 A;  2BOK L;  1BF9 A;  1PXX A;  3HO3 A;  3FCS B;  1EMO A;  2WFT A;  4RRW A;  1WU1 B;  3OLT A;  1IP0 A;  1J9C L;  1IVO C;  1IGX A;  1XFE A;  1HT5 A;  3N8W B;  2XBV L;  1LMM A;  2J95 B;  2VH0 B;  1KLJ L;  2Y80 B;  1PRH A;  3IJE B;  3HS7 A;  1M1X B;  4OTY A;  1Z6E L;  2WPH E;  2WYJ B;  4Z0L A;  1W7X L;  3C9A C;  2Y5H L;  3LIW B;  2PUQ L;  4Y6D B;  4E1G A;  3N8Y B;  3GIS X;  1ATE A;  1KLO A;  4CUE A;  2XC5 L;  1OB1 C;  3BPS E;  3CEN L;  1IQN L;  3LC5 B;  2BOU A;  2DDU A;  2BO2 A;  1DX5 I;  5F19 A;  1FSB A;  1YUG A;  2D1J B;  3FBY A;  3KL6 B;  4RRX A;  4O02 B;  1IQH L;  3Q3K B;  5IKR A;  2MGR A;  2WZP P;  1YGC L;  3LC3 B;  4MMZ B;  3U73 A;  2W2Q E;  1FF7 A;  2NPR A;  1FAK L;  5K0H B;  4RRZ A;  1FFM A;  1HX2 A;  1A3P A;  2VWO L;  3M37 L;  3KQD L;  3MQE A;  1EMN A;  1WHF A;  2EI6 B;  2KL7 A;  1U67 A;  1LMJ A;  1IJQ A;  3EGF A;  1L5G B;  2KNI A;  1Q4G A;  1F0R B;  2XC4 L;  5KN5 C;  1EAI C;  3F6U L;  1IQM L;  2BQW A;  4Y76 B;  1XKB A;  3GCW E;  5JVY A;  2EI7 B;  2WG3 C;  4YT6 L;  3Q7D A;  4YT7 L;  1EGF A;  3CFW A;  3TGF A;  2VVV L;  1ATA A;  4RS0 A;  5CKM A;  4X8T L;  1SZB A;  4NA9 L;  1G1Q A;  2AYL A;  4YZU B;  1NZI A;  3RR3 A;  1HRF A;  1G1S A;  1G1R A;  2XC0 L;  1IOE L;  1NFW B;  2TGF A;  4ISH L;  4RRY A;  4BDX A;  1KSN B;  4NGA L;  1HJ7 A;  3IIT B;  3BT2 A;  2P3F N;  2W3K B;  2UWL B;  1XKA L;  2W2O E;  3QMO A;  5CKQ A;  2W2N E;  4TGF A;  1XDT R;  2GD4 A;  3HS5 A;  1CQE A;  1TPG A;  2YGO A;  2RA0 L;  1EZQ B;  2K2T A;  2YGP A;  1JV2 B;  4MMY B;  2WG4 B;  2P16 L;  1MQ6 L;  1KIG L;  4D0E A;  3DEM A;  3NTB A;  1GK5 A;  4BTT A;  3HS6 A;  4BTI A;  5IKT A;  2J38 B;  3CA7 A;  1UZK A;  2WPJ E;  1EQG A;  1JL9 A;  2FLG A;  1CX2 A;  3LAQ A;  2EI8 B;  4Z6A L;  1FJS L;  2Y7Z B;  4JZF L;  4PH9 A;  3OLU A;  1IQI L;  1HAE A;  3S6X A;  1HAF A;  1LPG A;  1LQD A;  3ELA L;  2BQ6 A;  2I9A A;  1L3Y A;  1I0U A;  2YGQ A;  1NFU B;  1EPJ A;  1PTH A;  4X8S L;  4A94 C;  4D90 A;  2P3T A;  1UZQ A;  1IOX A;  2WPI E;  1V3X B;  3LTF B;  3NJP C;  1G2L B;  3KCG L;  5F1A A;  2J4I B;  2J34 B;  3LTG D;  4ZHA B;  2P26 A;  3ZYG A;  4FM5 A;  1F7M A;  1K36 A;  1HZ8 A;  1IQE L;  5COX A;  3MDL A;  4JYU L;  2K2S B;  3ASI A;  3M36 L;  4JYV L;  2P28 B;  4JZE L;  4CSY A;  4A7I A;  1CEJ A;  2H9E C;  3ZYJ B;  5IKQ A;  1CCV A;  3K9X A;  1COU A;  5I46 L;  4LMF A;  2XBX L;  4ISI L;  1P9J A;  2Q1J B;  2VWN L;  5JB8 E;  1URK A;  2P3F L;  2BQ7 A;  2XBW L;  5EGM B;  1YUF A;  4ZXY L;  5L2Z L;  2VH6 B;  6COX A;  2VVU L;  1NFX B;  1W8B L;  1AUT L;  4JZD L;  4ZH8 B;  1IQF L;  2W2P E;  4COX A;  3LN1 A;  3NTG A;  4C16 A;  1CVW L;  4O1Z A;  2FD6 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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