5EGMB

Development of a novel tricyclic class of potent and selective fixa inhibitors
Total Genus 11
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
11
sequence length
54
structure length
54
Chain Sequence
VTCNIKNGRCEQFCKNSADNKVVCSCTEGYRLAENQKSCEPAVPFPCGRVSVSQ
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Development of a novel tricyclic class of potent and selective FIXa inhibitors.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Homo sapiens
molecule keywords Coagulation factor IX
total genus 11
structure length 54
sequence length 54
ec nomenclature ec 3.4.21.22: Coagulation factor IXa.
pdb deposition date 2015-10-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF14670 FXa_inhibition Coagulation Factor Xa inhibitory site
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.25.10 Mainly Beta Ribbon Laminin Laminin 5egmB00
3ENSA 2PUQL 2VWNL 1GK5A 4G1MB 1IQFL 5L2YL 2VH6B 1ATAA 4PH9A 3H5CB 2P3FL 3R05A 1ATBA 4XL1A 1B9WA 2BQWA 3TZIA 3KQDL 3OLUA 1EPHA 3SOBB 1HT8A 4M10A 5I46L 1MQ6L 2FLBL 4X8UL 3CS7L 1LPGA 1WHFA 3N8YA 2OYUP 2P16L 2J4IB 3N8WA 2BMGA 4M11A 1OB1C 3LAQA 3ASIA 1IQLL 1NFYB 1EMOA 1IQKL 1EQGA 2EI6B 4ZHAB 4ZH8B 3F6UL 3KL6B 2WPKE 3KRKA 2BQ6A 1RFNB 2AYLA 1FFMA 1DIYA 2WG4B 1NFWB 2P94L 5CISA 2I9AA 1IQGL 2EI7B 4LMFA 5EGMB 3LN1A 1HX2A 3CFWA 2KV4A 4CUEA 2WYJB 1UZJA 4MMXB 5KIRA 1XFEA 1BF9A 2CJIB 3NJPC 3IJEB 1G2MB 1ZAQA 2UWOB 3HO5A 3N8YB 1G1RA 4TGFA 2VVVL 3U73A 3N8WB 4MMYB 1CCVA 1KSNB 4AQTA 2XBXL 4BDWA 5FDQA 4X8SL 2XBVL 1U67A 1CQEA 3OLTA 1QFKL 2W2NE 3HO4A 5IKTA 1COUA 5JB8E 4COXA 6COXA 2YGOA 5JBCE 4CSYA 2BZ6L 3GCWE 2PHBB 5COXA 1HJ7A 1ADXA 2Y5GL 1K36A 1HAFA 3M37L 4X8TL 2WYGB 1N1IA 1Z6EL 1G2LB 1W7XL 5JBBE 1IJQA 2UWLB 3PGHA 2I9BA 3IITB 2W2OE 1HREA 1UZKA 1Q4GA 4NA9L 1IQHL 3FFGL 4JYVL 2P28B 4XLWA 4RRWA 1XKAL 3BT2A 2BQ7A 1DX5I 5CKMA 3GCXE 4Z6AL 4Y7BB 1I0UA 5IKQA 3LIWB 4CUFA 2W3KB 2WG3C 3KK6A 1HZ8A 1EGFA 1URKA 4ZAEB 2G00L 2GD4A 2VWMK 3QCWA 3KCGL 2Y7ZB 3MDLA 3NT1A 2J2UB 2MGRA 2XC4L 4JZEL 1APOA 4JZFL 1NQLB 1A3PA 5KN5C 3V64C 3KQBL 1XKBA 1IP0A 3K9XA 4CUDA 1IQIL 1YUKB 2WPME 5JVZA 1K37A 1IQNL 4D0EA 2K2SB 2VWOL 3KQCL 1IQJL 4O02B 1EQHA 1P9JA 3U7UG 1NFXB 2W86A 2BOXA 1UZQA 1F0SB 4XBMA 5JBAE 1V3XB 1KIGL 3F1SB 1KLOA 1EPIA 1M1XB 3HS5A 2W26B 4YT6L 3LC5B 2WPLE 4Z0KB 2P3TA 3C9AC 2WPJE 4Y6DB 1IGXA 5IKVA 3GISX 1C5MF 4RRYA 1LMJA 2J95B 3KQEL 1PXXA 4RS0A 4JZDL 4NG9L 3LN0A 3LTFB 1G1SA 1EBVA 3TK5B 1O5DL 4C16A 1F7EA 3BT1A 3QMOA 2FZZL 2P3UA 5IKRA 3POYA 2TGFA 1IQEL 2VJ3A 2WFXB 4NGAL 4ISHL 1XDTR 3ZYGA 2W2PE 1EPGA 2MGPA 2FD6A 2W2QE 1LPZA 5E8DA 4BTTA 1PGEA 2P93L 2W2ME 3N8XA 3HO3A 2YGPA 2VVUL 4RRXA 4Y71B 2WFTA 1CEJA 2FLRL 4FM5A 1IVOC 2M74A 2EI8B 1HCGB 2WPIE 2Y7XB 1APQA 3Q3KB 1FJSL 2VVCK 4RUTA 2PR3B 1ATEA 2NPRA 1CCFA 1KLJL 3LTGD 2D1JB 3SW2A 2K2TA 2XBYL 4Y7AB 2P3FN 1W8BL 3NTGA 1EPJA 1TLEA 1L3YA 1DDXA 5JW1A 4ZXXL 1NPEB 2BO2A 1FF7A 1DQBA 1HAEA 2MHPA 2P26A 1YGCL 4YZUB 4LORA 2KL7A 5CKQA 3N8VA 1JV2B 2XBWL 1JL9A 1FE2A 2Y5FL 4OTYA 2Y38A 1HT5A 3Q7DA 1ATDA 1IQML 3TK6B 3MQEA 1NZIA 4BXSA 3FCSB 3ELAL 1KLIL 1WHEA 2J94B 3ZYIB 1MQ5L 3NTBA 3RR3A 1FSBA 1SZBA 5L2ZL 1NFUB 5JB9E 2ADXA 2J38B 2BOUA 3LC3B 2KB9A 2P95L 5F19A 3TH3L 4BTUA 1IGZA 1CVWL 3SOQA 3TBDA 2BOHA 3DEMA 5JVYA 1EZQB 1N7DA 3TGFA 2Y82B 3P5BL 5L30L 1FAKL 2F9BL 2XC5L 2RHPA 3ZYJB 1L5GB 1DVAL 5CKNA 4Y79B 3M36L 1P0SL 2VWLL 2J34B 2B7DL 2Y5HL 2WPHE 1X7AL 4D90A 4O1ZA 1MOXC 5K0HB 3BPSE 4ISIL 1HRFA 3EGFA 4RRZA 3SOVA 4JYUL 4X8VL 4OTJA 1PRHA 1LPKA 2Y81B 1YO8A 2XC0L 4E1GA 1IOEL 2OYEP 3HPTA 4A7IA 3HS6A 1F7MA 3CA7A 3N8ZA 2VH0B 1UZPA 3FBYA 1TOZA 5F1AA 1IOXA 1EMNA 2H9EL 4BXWA 1YUFA 1JBUL 1NT0A 4YT7L 1F0RB 2DDUA 3HS7A 3QH0A 1Z6CA 1EAIC 1PFXL 1AUTL 1PTHA 1CVUA 2W3IB 4D0FA 4BTIA 2UWPB 3V65B 4ZXYL 1G1TA 1WU1B 4Y76B 1U8CB 1G1QA 1YUGA 4Z0LA 1TPGA 4BDXA 2Y80B 3CENL 1FAXL 2FLGA 4MMZB 2JKHL 1CX2A 2BOKL 2RNLA 2Q1JB 1J9CL 2RA0L 1LQDA
chains in the Genus database with same CATH superfamily
3ENSA 2PUQL 2VWNL 1GK5A 4G1MB 1IQFL 5L2YL 2VH6B 1ATAA 4PH9A 3H5CB 2P3FL 3R05A 2YGQA 2HORA 1ATBA 4XL1A 1B9WA 2BQWA 3TZIA 3KQDL 3OLUA 1EPHA 3SOBB 1HT8A 4M10A 5I46L 1MQ6L 2FLBL 4X8UL 2H9EC 3CS7L 1LPGA 1WHFA 3N8YA 2OYUP 2P16L 2J4IB 3N8WA 2BMGA 4M11A 1OB1C 3LAQA 3ASIA 1IQLL 1NFYB 1EMOA 1IQKL 1EQGA 2EI6B 4ZHAB 4ZH8B 3F6UL 3KL6B 2WPKE 3KRKA 2BQ6A 1RFNB 2AYLA 1FFMA 1DIYA 2WG4B 1NFWB 2P94L 5CISA 2WZPP 2I9AA 1IQGL 2EI7B 4LMFA 5EGMB 2BSFA 3LN1A 1HX2A 3CFWA 2KV4A 4CUEA 2WYJB 1UZJA 4MMXB 5KIRA 1XFEA 1BF9A 2CJIB 3NJPC 3IJEB 1G2MB 1ZAQA 2UWOB 3HO5A 3N8YB 1G1RA 4TGFA 2VVVL 3U73A 3N8WB 4MMYB 1CCVA 1KSNB 4AQTA 2XBXL 4BDWA 5FDQA 4X8SL 2XBVL 1U67A 1CQEA 3OLTA 1QFKL 2W2NE 3HO4A 5IKTA 1COUA 5JB8E 4COXA 6COXA 2YGOA 5JBCE 4CSYA 2BZ6L 3GCWE 2PHBB 5COXA 1HJ7A 1ADXA 2Y5GL 1K36A 1HAFA 3M37L 4X8TL 2WYGB 1N1IA 1Z6EL 2HOXA 1G2LB 1W7XL 5JBBE 1IJQA 2UWLB 3PGHA 2I9BA 3IITB 2W2OE 4GU3A 1HREA 1UZKA 1Q4GA 4NA9L 1IQHL 3FFGL 4JYVL 2P28B 4XLWA 4RRWA 1XKAL 3BT2A 2BQ7A 1DX5I 5CKMA 3GCXE 4Z6AL 4Y7BB 1I0UA 5IKQA 3LIWB 4CUFA 2W3KB 2WG3C 3KK6A 1HZ8A 1EGFA 1URKA 4ZAEB 2G00L 2GD4A 2VWMK 3QCWA 3KCGL 2Y7ZB 3MDLA 3NT1A 2J2UB 2JJLA 2MGRA 2XC4L 4JZEL 1APOA 4JZFL 2VRSA 1NQLB 1A3PA 5KN5C 1V1HA 3V64C 3KQBL 4GU4A 1XKBA 1IP0A 3K9XA 4CUDA 1IQIL 1YUKB 2WPME 5JVZA 1K37A 1IQNL 4D0EA 2K2SB 2VWOL 3KQCL 1IQJL 4O02B 1EQHA 1P9JA 1LMMA 3U7UG 1NFXB 2W86A 1LK9A 2BOXA 1UZQA 1F0SB 2KNIA 4XBMA 2BT7A 5JBAE 1V3XB 1KIGL 3F1SB 1KLOA 1EPIA 1M1XB 3HS5A 2W26B 4YT6L 3LC5B 2WPLE 4Z0KB 2P3TA 3C9AC 2WPJE 4Y6DB 1IGXA 5IKVA 3GISX 1C5MF 4RRYA 1LMJA 2J95B 3KQEL 1PXXA 4RS0A 4JZDL 4NG9L 3LN0A 3LTFB 1G1SA 1EBVA 3TK5B 1O5DL 4C16A 1F7EA 3BT1A 3QMOA 2FZZL 2P3UA 5IKRA 3POYA 3S6XA 2TGFA 1IQEL 2BT8A 2VJ3A 2WFXB 4NGAL 4ISHL 1XDTR 3ZYGA 2W2PE 1EPGA 2MGPA 1KKEA 2FD6A 2W2QE 1LPZA 5E8DA 4BTTA 1PGEA 2P93L 2W2ME 3N8XA 3HO3A 2YGPA 2VVUL 4RRXA 1QIUA 4Y71B 2WFTA 1CEJA 2FLRL 4FM5A 1IVOC 2M74A 2EI8B 1HCGB 2WPIE 2Y7XB 1APQA 3Q3KB 1FJSL 2VVCK 4RUTA 2PR3B 1ATEA 2NPRA 1CCFA 1KLJL 3LTGD 2D1JB 3SW2A 2K2TA 2XBYL 4Y7AB 2P3FN 1W8BL 3NTGA 1EPJA 1TLEA 1L3YA 1DDXA 5JW1A 4ZXXL 1NPEB 2BO2A 1FF7A 1DQBA 1HAEA 2MHPA 2P26A 1YGCL 4YZUB 4LORA 2KL7A 5CKQA 3N8VA 1V1IA 1JV2B 2XBWL 1JL9A 1FE2A 2Y5FL 4OTYA 2Y38A 1HT5A 3Q7DA 1ATDA 1IQML 3TK6B 3MQEA 1NZIA 4BXSA 3FCSB 3ELAL 1KLIL 1WHEA 2J94B 3ZYIB 1MQ5L 3NTBA 3RR3A 1FSBA 1SZBA 5L2ZL 1NFUB 5JB9E 2ADXA 2J38B 2BOUA 3LC3B 2KB9A 2P95L 5F19A 3TH3L 4BTUA 1IGZA 1CVWL 3SOQA 3TBDA 2BOHA 3DEMA 5JVYA 1EZQB 1N7DA 3TGFA 2Y82B 3P5BL 5L30L 1FAKL 2F9BL 2XC5L 2RHPA 3ZYJB 1L5GB 1DVAL 5CKNA 4Y79B 3M36L 1P0SL 2VWLL 2J34B 2B7DL 2Y5HL 2WPHE 1X7AL 4D90A 4O1ZA 1MOXC 5K0HB 3BPSE 4ISIL 1HRFA 3EGFA 4RRZA 3SOVA 4JYUL 4X8VL 4OTJA 1PRHA 1LPKA 2Y81B 1YO8A 2XC0L 4E1GA 1IOEL 2OYEP 3HPTA 4A7IA 3HS6A 1F7MA 3CA7A 3N8ZA 2VH0B 1UZPA 3FBYA 1TOZA 5F1AA 1IOXA 1EMNA 2H9EL 4BXWA 1YUFA 1JBUL 1NT0A 4YT7L 1F0RB 2DDUA 4A94C 3HS7A 3QH0A 1Z6CA 1EAIC 1PFXL 1AUTL 1PTHA 1CVUA 2W3IB 4D0FA 4BTIA 2UWPB 3V65B 4ZXYL 1G1TA 1WU1B 4Y76B 1U8CB 1G1QA 1YUGA 4Z0LA 1TPGA 4BDXA 2Y80B 3CENL 1FAXL 2FLGA 4MMZB 2JKHL 1CX2A 2BOKL 2RNLA 2Q1JB 1J9CL 2RA0L 1LQDA
chains in the Genus database with same CATH topology
3ENSA 2PUQL 2VWNL 1GK5A 4G1MB 1IQFL 5L2YL 2VH6B 1ATAA 4PH9A 3H5CB 2P3FL 3R05A 2YGQA 1ATBA 4XL1A 1B9WA 2BQWA 3TZIA 3KQDL 3OLUA 1EPHA 3SOBB 1HT8A 4M10A 5I46L 1MQ6L 2FLBL 4X8UL 2H9EC 3CS7L 1LPGA 1WHFA 3N8YA 2OYUP 2P16L 2J4IB 3N8WA 2BMGA 4M11A 1OB1C 3LAQA 3ASIA 1IQLL 1NFYB 1EMOA 1IQKL 1EQGA 2EI6B 4ZHAB 4ZH8B 3F6UL 3KL6B 2WPKE 3KRKA 2BQ6A 1RFNB 2AYLA 1FFMA 1DIYA 2WG4B 1NFWB 2P94L 5CISA 2WZPP 2I9AA 1IQGL 2EI7B 4LMFA 5EGMB 3LN1A 1HX2A 3CFWA 2KV4A 4CUEA 2WYJB 1UZJA 4MMXB 5KIRA 1XFEA 1BF9A 2CJIB 3NJPC 3IJEB 1G2MB 1ZAQA 2UWOB 3HO5A 3N8YB 1G1RA 4TGFA 2VVVL 3U73A 3N8WB 4MMYB 1CCVA 1KSNB 4AQTA 2XBXL 4BDWA 5FDQA 4X8SL 2XBVL 1U67A 1CQEA 3OLTA 1QFKL 2W2NE 3HO4A 5IKTA 1COUA 5JB8E 4COXA 6COXA 2YGOA 5JBCE 4CSYA 2BZ6L 3GCWE 2PHBB 5COXA 1HJ7A 1ADXA 2Y5GL 1K36A 1HAFA 3M37L 4X8TL 2WYGB 1N1IA 1Z6EL 1G2LB 1W7XL 5JBBE 1IJQA 2UWLB 3PGHA 2I9BA 3IITB 2W2OE 1HREA 1UZKA 1Q4GA 4NA9L 1IQHL 3FFGL 4JYVL 2P28B 4XLWA 4RRWA 1XKAL 3BT2A 2BQ7A 1DX5I 5CKMA 3GCXE 4Z6AL 4Y7BB 1I0UA 5IKQA 3LIWB 4CUFA 2W3KB 2WG3C 3KK6A 1HZ8A 1EGFA 1URKA 4ZAEB 2G00L 2GD4A 2VWMK 3QCWA 3KCGL 2Y7ZB 3MDLA 3NT1A 2J2UB 2MGRA 2XC4L 4JZEL 1APOA 4JZFL 1NQLB 1A3PA 5KN5C 3V64C 3KQBL 1XKBA 1IP0A 3K9XA 4CUDA 1IQIL 1YUKB 2WPME 5JVZA 1K37A 1IQNL 4D0EA 2K2SB 2VWOL 3KQCL 1IQJL 4O02B 1EQHA 1P9JA 1LMMA 3U7UG 1NFXB 2W86A 2BOXA 1UZQA 1F0SB 2KNIA 4XBMA 5JBAE 1V3XB 1KIGL 3F1SB 1KLOA 1EPIA 1M1XB 3HS5A 2W26B 4YT6L 3LC5B 2WPLE 4Z0KB 2P3TA 3C9AC 2WPJE 4Y6DB 1IGXA 5IKVA 3GISX 1C5MF 4RRYA 1LMJA 2J95B 3KQEL 1PXXA 4RS0A 4JZDL 4NG9L 3LN0A 3LTFB 1G1SA 1EBVA 3TK5B 1O5DL 4C16A 1F7EA 3BT1A 3QMOA 2FZZL 2P3UA 5IKRA 3POYA 3S6XA 2TGFA 1IQEL 2VJ3A 2WFXB 4NGAL 4ISHL 1XDTR 3ZYGA 2W2PE 1EPGA 2MGPA 2FD6A 2W2QE 1LPZA 5E8DA 4BTTA 1PGEA 2P93L 2W2ME 3N8XA 3HO3A 2YGPA 2VVUL 4RRXA 4Y71B 2WFTA 1CEJA 2FLRL 4FM5A 1IVOC 2M74A 2EI8B 1HCGB 2WPIE 2Y7XB 1APQA 3Q3KB 1FJSL 2VVCK 4RUTA 2PR3B 1ATEA 2NPRA 1CCFA 1KLJL 3LTGD 2D1JB 3SW2A 2K2TA 2XBYL 4Y7AB 2P3FN 1W8BL 3NTGA 1EPJA 1TLEA 1L3YA 1DDXA 5JW1A 4ZXXL 1NPEB 2BO2A 1FF7A 1DQBA 1HAEA 2MHPA 2P26A 1YGCL 4YZUB 4LORA 2KL7A 5CKQA 3N8VA 1JV2B 2XBWL 1JL9A 1FE2A 2Y5FL 4OTYA 2Y38A 1HT5A 3Q7DA 1ATDA 1IQML 3TK6B 3MQEA 1NZIA 4BXSA 3FCSB 3ELAL 1KLIL 1WHEA 2J94B 3ZYIB 1MQ5L 3NTBA 3RR3A 1FSBA 1SZBA 5L2ZL 1NFUB 5JB9E 2ADXA 2J38B 2BOUA 3LC3B 2KB9A 2P95L 5F19A 3TH3L 4BTUA 1IGZA 1CVWL 3SOQA 3TBDA 2BOHA 3DEMA 5JVYA 1EZQB 1N7DA 3TGFA 2Y82B 3P5BL 5L30L 1FAKL 2F9BL 2XC5L 2RHPA 3ZYJB 1L5GB 1DVAL 5CKNA 4Y79B 3M36L 1P0SL 2VWLL 2J34B 2B7DL 2Y5HL 2WPHE 1X7AL 4D90A 4O1ZA 1MOXC 5K0HB 3BPSE 4ISIL 1HRFA 3EGFA 4RRZA 3SOVA 4JYUL 4X8VL 4OTJA 1PRHA 1LPKA 2Y81B 1YO8A 2XC0L 4E1GA 1IOEL 2OYEP 3HPTA 4A7IA 3HS6A 1F7MA 3CA7A 3N8ZA 2VH0B 1UZPA 3FBYA 1TOZA 5F1AA 1IOXA 1EMNA 2H9EL 4BXWA 1YUFA 1JBUL 1NT0A 4YT7L 1F0RB 2DDUA 4A94C 3HS7A 3QH0A 1Z6CA 1EAIC 1PFXL 1AUTL 1PTHA 1CVUA 2W3IB 4D0FA 4BTIA 2UWPB 3V65B 4ZXYL 1G1TA 1WU1B 4Y76B 1U8CB 1G1QA 1YUGA 4Z0LA 1TPGA 4BDXA 2Y80B 3CENL 1FAXL 2FLGA 4MMZB 2JKHL 1CX2A 2BOKL 2RNLA 2Q1JB 1J9CL 2RA0L 1LQDA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3ENS A;  2PUQ L;  2VWN L;  1GK5 A;  4G1M B;  1IQF L;  5L2Y L;  2VH6 B;  1ATA A;  4PH9 A;  3H5C B;  2P3F L;  3R05 A;  1ATB A;  4XL1 A;  1B9W A;  2BQW A;  3TZI A;  3KQD L;  3OLU A;  1EPH A;  3SOB B;  1HT8 A;  4M10 A;  5I46 L;  1MQ6 L;  2FLB L;  4X8U L;  3CS7 L;  1LPG A;  1WHF A;  3N8Y A;  2OYU P;  2P16 L;  2J4I B;  3N8W A;  2BMG A;  4M11 A;  1OB1 C;  3LAQ A;  3ASI A;  1IQL L;  1NFY B;  1EMO A;  1IQK L;  1EQG A;  2EI6 B;  4ZHA B;  4ZH8 B;  3F6U L;  3KL6 B;  2WPK E;  3KRK A;  2BQ6 A;  1RFN B;  2AYL A;  1FFM A;  1DIY A;  2WG4 B;  1NFW B;  2P94 L;  5CIS A;  2I9A A;  1IQG L;  2EI7 B;  4LMF A;  5EGM B;  3LN1 A;  1HX2 A;  3CFW A;  2KV4 A;  4CUE A;  2WYJ B;  1UZJ A;  4MMX B;  5KIR A;  1XFE A;  1BF9 A;  2CJI B;  3NJP C;  3IJE B;  1G2M B;  1ZAQ A;  2UWO B;  3HO5 A;  3N8Y B;  1G1R A;  4TGF A;  2VVV L;  3U73 A;  3N8W B;  4MMY B;  1CCV A;  1KSN B;  4AQT A;  2XBX L;  4BDW A;  5FDQ A;  4X8S L;  2XBV L;  1U67 A;  1CQE A;  3OLT A;  1QFK L;  2W2N E;  3HO4 A;  5IKT A;  1COU A;  5JB8 E;  4COX A;  6COX A;  2YGO A;  5JBC E;  4CSY A;  2BZ6 L;  3GCW E;  2PHB B;  5COX A;  1HJ7 A;  1ADX A;  2Y5G L;  1K36 A;  1HAF A;  3M37 L;  4X8T L;  2WYG B;  1N1I A;  1Z6E L;  1G2L B;  1W7X L;  5JBB E;  1IJQ A;  2UWL B;  3PGH A;  2I9B A;  3IIT B;  2W2O E;  1HRE A;  1UZK A;  1Q4G A;  4NA9 L;  1IQH L;  3FFG L;  4JYV L;  2P28 B;  4XLW A;  4RRW A;  1XKA L;  3BT2 A;  2BQ7 A;  1DX5 I;  5CKM A;  3GCX E;  4Z6A L;  4Y7B B;  1I0U A;  5IKQ A;  3LIW B;  4CUF A;  2W3K B;  2WG3 C;  3KK6 A;  1HZ8 A;  1EGF A;  1URK A;  4ZAE B;  2G00 L;  2GD4 A;  2VWM K;  3QCW A;  3KCG L;  2Y7Z B;  3MDL A;  3NT1 A;  2J2U B;  2MGR A;  2XC4 L;  4JZE L;  1APO A;  4JZF L;  1NQL B;  1A3P A;  5KN5 C;  3V64 C;  3KQB L;  1XKB A;  1IP0 A;  3K9X A;  4CUD A;  1IQI L;  1YUK B;  2WPM E;  5JVZ A;  1K37 A;  1IQN L;  4D0E A;  2K2S B;  2VWO L;  3KQC L;  1IQJ L;  4O02 B;  1EQH A;  1P9J A;  3U7U G;  1NFX B;  2W86 A;  2BOX A;  1UZQ A;  1F0S B;  4XBM A;  5JBA E;  1V3X B;  1KIG L;  3F1S B;  1KLO A;  1EPI A;  1M1X B;  3HS5 A;  2W26 B;  4YT6 L;  3LC5 B;  2WPL E;  4Z0K B;  2P3T A;  3C9A C;  2WPJ E;  4Y6D B;  1IGX A;  5IKV A;  3GIS X;  1C5M F;  4RRY A;  1LMJ A;  2J95 B;  3KQE L;  1PXX A;  4RS0 A;  4JZD L;  4NG9 L;  3LN0 A;  3LTF B;  1G1S A;  1EBV A;  3TK5 B;  1O5D L;  4C16 A;  1F7E A;  3BT1 A;  3QMO A;  2FZZ L;  2P3U A;  5IKR A;  3POY A;  2TGF A;  1IQE L;  2VJ3 A;  2WFX B;  4NGA L;  4ISH L;  1XDT R;  3ZYG A;  2W2P E;  1EPG A;  2MGP A;  2FD6 A;  2W2Q E;  1LPZ A;  5E8D A;  4BTT A;  1PGE A;  2P93 L;  2W2M E;  3N8X A;  3HO3 A;  2YGP A;  2VVU L;  4RRX A;  4Y71 B;  2WFT A;  1CEJ A;  2FLR L;  4FM5 A;  1IVO C;  2M74 A;  2EI8 B;  1HCG B;  2WPI E;  2Y7X B;  1APQ A;  3Q3K B;  1FJS L;  2VVC K;  4RUT A;  2PR3 B;  1ATE A;  2NPR A;  1CCF A;  1KLJ L;  3LTG D;  2D1J B;  3SW2 A;  2K2T A;  2XBY L;  4Y7A B;  2P3F N;  1W8B L;  3NTG A;  1EPJ A;  1TLE A;  1L3Y A;  1DDX A;  5JW1 A;  4ZXX L;  1NPE B;  2BO2 A;  1FF7 A;  1DQB A;  1HAE A;  2MHP A;  2P26 A;  1YGC L;  4YZU B;  4LOR A;  2KL7 A;  5CKQ A;  3N8V A;  1JV2 B;  2XBW L;  1JL9 A;  1FE2 A;  2Y5F L;  4OTY A;  2Y38 A;  1HT5 A;  3Q7D A;  1ATD A;  1IQM L;  3TK6 B;  3MQE A;  1NZI A;  4BXS A;  3FCS B;  3ELA L;  1KLI L;  1WHE A;  2J94 B;  3ZYI B;  1MQ5 L;  3NTB A;  3RR3 A;  1FSB A;  1SZB A;  5L2Z L;  1NFU B;  5JB9 E;  2ADX A;  2J38 B;  2BOU A;  3LC3 B;  2KB9 A;  2P95 L;  5F19 A;  3TH3 L;  4BTU A;  1IGZ A;  1CVW L;  3SOQ A;  3TBD A;  2BOH A;  3DEM A;  5JVY A;  1EZQ B;  1N7D A;  3TGF A;  2Y82 B;  3P5B L;  5L30 L;  1FAK L;  2F9B L;  2XC5 L;  2RHP A;  3ZYJ B;  1L5G B;  1DVA L;  5CKN A;  4Y79 B;  3M36 L;  1P0S L;  2VWL L;  2J34 B;  2B7D L;  2Y5H L;  2WPH E;  1X7A L;  4D90 A;  4O1Z A;  1MOX C;  5K0H B;  3BPS E;  4ISI L;  1HRF A;  3EGF A;  4RRZ A;  3SOV A;  4JYU L;  4X8V L;  4OTJ A;  1PRH A;  1LPK A;  2Y81 B;  1YO8 A;  2XC0 L;  4E1G A;  1IOE L;  2OYE P;  3HPT A;  4A7I A;  3HS6 A;  1F7M A;  3CA7 A;  3N8Z A;  2VH0 B;  1UZP A;  3FBY A;  1TOZ A;  5F1A A;  1IOX A;  1EMN A;  2H9E L;  4BXW A;  1YUF A;  1JBU L;  1NT0 A;  4YT7 L;  1F0R B;  2DDU A;  3HS7 A;  3QH0 A;  1Z6C A;  1EAI C;  1PFX L;  1AUT L;  1PTH A;  1CVU A;  2W3I B;  4D0F A;  4BTI A;  2UWP B;  3V65 B;  4ZXY L;  1G1T A;  1WU1 B;  4Y76 B;  1U8C B;  1G1Q A;  1YUG A;  4Z0L A;  1TPG A;  4BDX A;  2Y80 B;  3CEN L;  1FAX L;  2FLG A;  4MMZ B;  2JKH L;  1CX2 A;  2BOK L;  2RNL A;  2Q1J B;  1J9C L;  2RA0 L;  1LQD A; 
#chains in the Genus database with same CATH topology
 3ENS A;  2PUQ L;  2VWN L;  1GK5 A;  4G1M B;  1IQF L;  5L2Y L;  2VH6 B;  1ATA A;  4PH9 A;  3H5C B;  2P3F L;  3R05 A;  2YGQ A;  2HOR A;  1ATB A;  4XL1 A;  1B9W A;  2BQW A;  3TZI A;  3KQD L;  3OLU A;  1EPH A;  3SOB B;  1HT8 A;  4M10 A;  5I46 L;  1MQ6 L;  2FLB L;  4X8U L;  2H9E C;  3CS7 L;  1LPG A;  1WHF A;  3N8Y A;  2OYU P;  2P16 L;  2J4I B;  3N8W A;  2BMG A;  4M11 A;  1OB1 C;  3LAQ A;  3ASI A;  1IQL L;  1NFY B;  1EMO A;  1IQK L;  1EQG A;  2EI6 B;  4ZHA B;  4ZH8 B;  3F6U L;  3KL6 B;  2WPK E;  3KRK A;  2BQ6 A;  1RFN B;  2AYL A;  1FFM A;  1DIY A;  2WG4 B;  1NFW B;  2P94 L;  5CIS A;  2WZP P;  2I9A A;  1IQG L;  2EI7 B;  4LMF A;  5EGM B;  2BSF A;  3LN1 A;  1HX2 A;  3CFW A;  2KV4 A;  4CUE A;  2WYJ B;  1UZJ A;  4MMX B;  5KIR A;  1XFE A;  1BF9 A;  2CJI B;  3NJP C;  3IJE B;  1G2M B;  1ZAQ A;  2UWO B;  3HO5 A;  3N8Y B;  1G1R A;  4TGF A;  2VVV L;  3U73 A;  3N8W B;  4MMY B;  1CCV A;  1KSN B;  4AQT A;  2XBX L;  4BDW A;  5FDQ A;  4X8S L;  2XBV L;  1U67 A;  1CQE A;  3OLT A;  1QFK L;  2W2N E;  3HO4 A;  5IKT A;  1COU A;  5JB8 E;  4COX A;  6COX A;  2YGO A;  5JBC E;  4CSY A;  2BZ6 L;  3GCW E;  2PHB B;  5COX A;  1HJ7 A;  1ADX A;  2Y5G L;  1K36 A;  1HAF A;  3M37 L;  4X8T L;  2WYG B;  1N1I A;  1Z6E L;  2HOX A;  1G2L B;  1W7X L;  5JBB E;  1IJQ A;  2UWL B;  3PGH A;  2I9B A;  3IIT B;  2W2O E;  4GU3 A;  1HRE A;  1UZK A;  1Q4G A;  4NA9 L;  1IQH L;  3FFG L;  4JYV L;  2P28 B;  4XLW A;  4RRW A;  1XKA L;  3BT2 A;  2BQ7 A;  1DX5 I;  5CKM A;  3GCX E;  4Z6A L;  4Y7B B;  1I0U A;  5IKQ A;  3LIW B;  4CUF A;  2W3K B;  2WG3 C;  3KK6 A;  1HZ8 A;  1EGF A;  1URK A;  4ZAE B;  2G00 L;  2GD4 A;  2VWM K;  3QCW A;  3KCG L;  2Y7Z B;  3MDL A;  3NT1 A;  2J2U B;  2JJL A;  2MGR A;  2XC4 L;  4JZE L;  1APO A;  4JZF L;  2VRS A;  1NQL B;  1A3P A;  5KN5 C;  1V1H A;  3V64 C;  3KQB L;  4GU4 A;  1XKB A;  1IP0 A;  3K9X A;  4CUD A;  1IQI L;  1YUK B;  2WPM E;  5JVZ A;  1K37 A;  1IQN L;  4D0E A;  2K2S B;  2VWO L;  3KQC L;  1IQJ L;  4O02 B;  1EQH A;  1P9J A;  1LMM A;  3U7U G;  1NFX B;  2W86 A;  1LK9 A;  2BOX A;  1UZQ A;  1F0S B;  2KNI A;  4XBM A;  2BT7 A;  5JBA E;  1V3X B;  1KIG L;  3F1S B;  1KLO A;  1EPI A;  1M1X B;  3HS5 A;  2W26 B;  4YT6 L;  3LC5 B;  2WPL E;  4Z0K B;  2P3T A;  3C9A C;  2WPJ E;  4Y6D B;  1IGX A;  5IKV A;  3GIS X;  1C5M F;  4RRY A;  1LMJ A;  2J95 B;  3KQE L;  1PXX A;  4RS0 A;  4JZD L;  4NG9 L;  3LN0 A;  3LTF B;  1G1S A;  1EBV A;  3TK5 B;  1O5D L;  4C16 A;  1F7E A;  3BT1 A;  3QMO A;  2FZZ L;  2P3U A;  5IKR A;  3POY A;  3S6X A;  2TGF A;  1IQE L;  2BT8 A;  2VJ3 A;  2WFX B;  4NGA L;  4ISH L;  1XDT R;  3ZYG A;  2W2P E;  1EPG A;  2MGP A;  1KKE A;  2FD6 A;  2W2Q E;  1LPZ A;  5E8D A;  4BTT A;  1PGE A;  2P93 L;  2W2M E;  3N8X A;  3HO3 A;  2YGP A;  2VVU L;  4RRX A;  1QIU A;  4Y71 B;  2WFT A;  1CEJ A;  2FLR L;  4FM5 A;  1IVO C;  2M74 A;  2EI8 B;  1HCG B;  2WPI E;  2Y7X B;  1APQ A;  3Q3K B;  1FJS L;  2VVC K;  4RUT A;  2PR3 B;  1ATE A;  2NPR A;  1CCF A;  1KLJ L;  3LTG D;  2D1J B;  3SW2 A;  2K2T A;  2XBY L;  4Y7A B;  2P3F N;  1W8B L;  3NTG A;  1EPJ A;  1TLE A;  1L3Y A;  1DDX A;  5JW1 A;  4ZXX L;  1NPE B;  2BO2 A;  1FF7 A;  1DQB A;  1HAE A;  2MHP A;  2P26 A;  1YGC L;  4YZU B;  4LOR A;  2KL7 A;  5CKQ A;  3N8V A;  1V1I A;  1JV2 B;  2XBW L;  1JL9 A;  1FE2 A;  2Y5F L;  4OTY A;  2Y38 A;  1HT5 A;  3Q7D A;  1ATD A;  1IQM L;  3TK6 B;  3MQE A;  1NZI A;  4BXS A;  3FCS B;  3ELA L;  1KLI L;  1WHE A;  2J94 B;  3ZYI B;  1MQ5 L;  3NTB A;  3RR3 A;  1FSB A;  1SZB A;  5L2Z L;  1NFU B;  5JB9 E;  2ADX A;  2J38 B;  2BOU A;  3LC3 B;  2KB9 A;  2P95 L;  5F19 A;  3TH3 L;  4BTU A;  1IGZ A;  1CVW L;  3SOQ A;  3TBD A;  2BOH A;  3DEM A;  5JVY A;  1EZQ B;  1N7D A;  3TGF A;  2Y82 B;  3P5B L;  5L30 L;  1FAK L;  2F9B L;  2XC5 L;  2RHP A;  3ZYJ B;  1L5G B;  1DVA L;  5CKN A;  4Y79 B;  3M36 L;  1P0S L;  2VWL L;  2J34 B;  2B7D L;  2Y5H L;  2WPH E;  1X7A L;  4D90 A;  4O1Z A;  1MOX C;  5K0H B;  3BPS E;  4ISI L;  1HRF A;  3EGF A;  4RRZ A;  3SOV A;  4JYU L;  4X8V L;  4OTJ A;  1PRH A;  1LPK A;  2Y81 B;  1YO8 A;  2XC0 L;  4E1G A;  1IOE L;  2OYE P;  3HPT A;  4A7I A;  3HS6 A;  1F7M A;  3CA7 A;  3N8Z A;  2VH0 B;  1UZP A;  3FBY A;  1TOZ A;  5F1A A;  1IOX A;  1EMN A;  2H9E L;  4BXW A;  1YUF A;  1JBU L;  1NT0 A;  4YT7 L;  1F0R B;  2DDU A;  4A94 C;  3HS7 A;  3QH0 A;  1Z6C A;  1EAI C;  1PFX L;  1AUT L;  1PTH A;  1CVU A;  2W3I B;  4D0F A;  4BTI A;  2UWP B;  3V65 B;  4ZXY L;  1G1T A;  1WU1 B;  4Y76 B;  1U8C B;  1G1Q A;  1YUG A;  4Z0L A;  1TPG A;  4BDX A;  2Y80 B;  3CEN L;  1FAX L;  2FLG A;  4MMZ B;  2JKH L;  1CX2 A;  2BOK L;  2RNL A;  2Q1J B;  1J9C L;  2RA0 L;  1LQD A; 
#chains in the Genus database with same CATH homology
 3ENS A;  2PUQ L;  2VWN L;  1GK5 A;  4G1M B;  1IQF L;  5L2Y L;  2VH6 B;  1ATA A;  4PH9 A;  3H5C B;  2P3F L;  3R05 A;  2YGQ A;  1ATB A;  4XL1 A;  1B9W A;  2BQW A;  3TZI A;  3KQD L;  3OLU A;  1EPH A;  3SOB B;  1HT8 A;  4M10 A;  5I46 L;  1MQ6 L;  2FLB L;  4X8U L;  2H9E C;  3CS7 L;  1LPG A;  1WHF A;  3N8Y A;  2OYU P;  2P16 L;  2J4I B;  3N8W A;  2BMG A;  4M11 A;  1OB1 C;  3LAQ A;  3ASI A;  1IQL L;  1NFY B;  1EMO A;  1IQK L;  1EQG A;  2EI6 B;  4ZHA B;  4ZH8 B;  3F6U L;  3KL6 B;  2WPK E;  3KRK A;  2BQ6 A;  1RFN B;  2AYL A;  1FFM A;  1DIY A;  2WG4 B;  1NFW B;  2P94 L;  5CIS A;  2WZP P;  2I9A A;  1IQG L;  2EI7 B;  4LMF A;  5EGM B;  3LN1 A;  1HX2 A;  3CFW A;  2KV4 A;  4CUE A;  2WYJ B;  1UZJ A;  4MMX B;  5KIR A;  1XFE A;  1BF9 A;  2CJI B;  3NJP C;  3IJE B;  1G2M B;  1ZAQ A;  2UWO B;  3HO5 A;  3N8Y B;  1G1R A;  4TGF A;  2VVV L;  3U73 A;  3N8W B;  4MMY B;  1CCV A;  1KSN B;  4AQT A;  2XBX L;  4BDW A;  5FDQ A;  4X8S L;  2XBV L;  1U67 A;  1CQE A;  3OLT A;  1QFK L;  2W2N E;  3HO4 A;  5IKT A;  1COU A;  5JB8 E;  4COX A;  6COX A;  2YGO A;  5JBC E;  4CSY A;  2BZ6 L;  3GCW E;  2PHB B;  5COX A;  1HJ7 A;  1ADX A;  2Y5G L;  1K36 A;  1HAF A;  3M37 L;  4X8T L;  2WYG B;  1N1I A;  1Z6E L;  1G2L B;  1W7X L;  5JBB E;  1IJQ A;  2UWL B;  3PGH A;  2I9B A;  3IIT B;  2W2O E;  1HRE A;  1UZK A;  1Q4G A;  4NA9 L;  1IQH L;  3FFG L;  4JYV L;  2P28 B;  4XLW A;  4RRW A;  1XKA L;  3BT2 A;  2BQ7 A;  1DX5 I;  5CKM A;  3GCX E;  4Z6A L;  4Y7B B;  1I0U A;  5IKQ A;  3LIW B;  4CUF A;  2W3K B;  2WG3 C;  3KK6 A;  1HZ8 A;  1EGF A;  1URK A;  4ZAE B;  2G00 L;  2GD4 A;  2VWM K;  3QCW A;  3KCG L;  2Y7Z B;  3MDL A;  3NT1 A;  2J2U B;  2MGR A;  2XC4 L;  4JZE L;  1APO A;  4JZF L;  1NQL B;  1A3P A;  5KN5 C;  3V64 C;  3KQB L;  1XKB A;  1IP0 A;  3K9X A;  4CUD A;  1IQI L;  1YUK B;  2WPM E;  5JVZ A;  1K37 A;  1IQN L;  4D0E A;  2K2S B;  2VWO L;  3KQC L;  1IQJ L;  4O02 B;  1EQH A;  1P9J A;  1LMM A;  3U7U G;  1NFX B;  2W86 A;  2BOX A;  1UZQ A;  1F0S B;  2KNI A;  4XBM A;  5JBA E;  1V3X B;  1KIG L;  3F1S B;  1KLO A;  1EPI A;  1M1X B;  3HS5 A;  2W26 B;  4YT6 L;  3LC5 B;  2WPL E;  4Z0K B;  2P3T A;  3C9A C;  2WPJ E;  4Y6D B;  1IGX A;  5IKV A;  3GIS X;  1C5M F;  4RRY A;  1LMJ A;  2J95 B;  3KQE L;  1PXX A;  4RS0 A;  4JZD L;  4NG9 L;  3LN0 A;  3LTF B;  1G1S A;  1EBV A;  3TK5 B;  1O5D L;  4C16 A;  1F7E A;  3BT1 A;  3QMO A;  2FZZ L;  2P3U A;  5IKR A;  3POY A;  3S6X A;  2TGF A;  1IQE L;  2VJ3 A;  2WFX B;  4NGA L;  4ISH L;  1XDT R;  3ZYG A;  2W2P E;  1EPG A;  2MGP A;  2FD6 A;  2W2Q E;  1LPZ A;  5E8D A;  4BTT A;  1PGE A;  2P93 L;  2W2M E;  3N8X A;  3HO3 A;  2YGP A;  2VVU L;  4RRX A;  4Y71 B;  2WFT A;  1CEJ A;  2FLR L;  4FM5 A;  1IVO C;  2M74 A;  2EI8 B;  1HCG B;  2WPI E;  2Y7X B;  1APQ A;  3Q3K B;  1FJS L;  2VVC K;  4RUT A;  2PR3 B;  1ATE A;  2NPR A;  1CCF A;  1KLJ L;  3LTG D;  2D1J B;  3SW2 A;  2K2T A;  2XBY L;  4Y7A B;  2P3F N;  1W8B L;  3NTG A;  1EPJ A;  1TLE A;  1L3Y A;  1DDX A;  5JW1 A;  4ZXX L;  1NPE B;  2BO2 A;  1FF7 A;  1DQB A;  1HAE A;  2MHP A;  2P26 A;  1YGC L;  4YZU B;  4LOR A;  2KL7 A;  5CKQ A;  3N8V A;  1JV2 B;  2XBW L;  1JL9 A;  1FE2 A;  2Y5F L;  4OTY A;  2Y38 A;  1HT5 A;  3Q7D A;  1ATD A;  1IQM L;  3TK6 B;  3MQE A;  1NZI A;  4BXS A;  3FCS B;  3ELA L;  1KLI L;  1WHE A;  2J94 B;  3ZYI B;  1MQ5 L;  3NTB A;  3RR3 A;  1FSB A;  1SZB A;  5L2Z L;  1NFU B;  5JB9 E;  2ADX A;  2J38 B;  2BOU A;  3LC3 B;  2KB9 A;  2P95 L;  5F19 A;  3TH3 L;  4BTU A;  1IGZ A;  1CVW L;  3SOQ A;  3TBD A;  2BOH A;  3DEM A;  5JVY A;  1EZQ B;  1N7D A;  3TGF A;  2Y82 B;  3P5B L;  5L30 L;  1FAK L;  2F9B L;  2XC5 L;  2RHP A;  3ZYJ B;  1L5G B;  1DVA L;  5CKN A;  4Y79 B;  3M36 L;  1P0S L;  2VWL L;  2J34 B;  2B7D L;  2Y5H L;  2WPH E;  1X7A L;  4D90 A;  4O1Z A;  1MOX C;  5K0H B;  3BPS E;  4ISI L;  1HRF A;  3EGF A;  4RRZ A;  3SOV A;  4JYU L;  4X8V L;  4OTJ A;  1PRH A;  1LPK A;  2Y81 B;  1YO8 A;  2XC0 L;  4E1G A;  1IOE L;  2OYE P;  3HPT A;  4A7I A;  3HS6 A;  1F7M A;  3CA7 A;  3N8Z A;  2VH0 B;  1UZP A;  3FBY A;  1TOZ A;  5F1A A;  1IOX A;  1EMN A;  2H9E L;  4BXW A;  1YUF A;  1JBU L;  1NT0 A;  4YT7 L;  1F0R B;  2DDU A;  4A94 C;  3HS7 A;  3QH0 A;  1Z6C A;  1EAI C;  1PFX L;  1AUT L;  1PTH A;  1CVU A;  2W3I B;  4D0F A;  4BTI A;  2UWP B;  3V65 B;  4ZXY L;  1G1T A;  1WU1 B;  4Y76 B;  1U8C B;  1G1Q A;  1YUG A;  4Z0L A;  1TPG A;  4BDX A;  2Y80 B;  3CEN L;  1FAX L;  2FLG A;  4MMZ B;  2JKH L;  1CX2 A;  2BOK L;  2RNL A;  2Q1J B;  1J9C L;  2RA0 L;  1LQD A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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