5L2YL

Factor viia in complex with the inhibitor 1-[(2r,15r)-2-[(1-amino-4-fluoroisoquinolin-6-yl)amino]-4,15,20-trimethyl-3,12-dioxo-13-oxa-4,11-diazatricyclo[14.2.2.1~6,10~]henicosa-1(18),6,8,10(21),16,19-hexaen-7-yl] cyclobutane-1-carboxylic acid
Total Genus 12
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
12
sequence length
55
structure length
55
Chain Sequence
ICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILEKR
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Synthesis and P1' SAR exploration of potent macrocyclic tissue factor-factor VIIa inhibitors.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Homo sapiens
molecule keywords Coagulation factor VII (Heavy Chain)
total genus 12
structure length 55
sequence length 55
ec nomenclature ec 3.4.21.21: Coagulation factor VIIa.
pdb deposition date 2016-08-02
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.25.10 Mainly Beta Ribbon Laminin Laminin 5l2yL00
3KQDL 5I46L 1YGCL 1EGFA 1TOZA 3N8WB 1X7AL 3RR3A 2WPIE 4Z0LA 1NFWB 1W8BL 1IGXA 2WPHE 3GCXE 2BOHA 2BQWA 2P3UA 2W2ME 1LQDA 2FLGA 1BF9A 2PHBB 3U7UG 1NFYB 2B7DL 3LN1A 2BQ7A 5IKQA 1G1SA 2RHPA 1IQHL 1IJQA 3GCWE 1TPGA 2J2UB 2WG3C 4MMXB 2W86A 4COXA 2GD4A 1EQHA 1FE2A 1FSBA 1EPIA 4Z6AL 2VH0B 4ZXXL 1MQ5L 2XC0L 3CFWA 1IOXA 5CKQA 1G1QA 3HS5A 4Y7BB 5E8DA 4JZFL 2MGRA 3ZYJB 2RNLA 2WYGB 5L30L 2P26A 1APQA 2Y80B 1IQIL 3TK6B 1IGZA 5JVYA 1OB1C 3HO3A 1YUKB 3FCSB 1HRFA 3HO5A 2Y82B 3ELAL 4O1ZA 3N8XA 4BXWA 2ADXA 1KLOA 1F0RB 1RFNB 4M10A 1PGEA 3EGFA 4CUFA 2JKHL 2FD6A 4YT6L 4BTIA 5CISA 1O5DL 4CSYA 5KIRA 1HCGB 5JBAE 2P28B 1AUTL 3Q3KB 3NT1A 2W2QE 2I9AA 1L3YA 1ATEA 1KLJL 4NA9L 3LIWB 1HAFA 3BPSE 1EQGA 1K37A 1HAEA 2WPLE 4ZH8B 1SZBA 2EI6B 1PRHA 1ATDA 1G1RA 1TLEA 4BXSA 2NPRA 4JZDL 1HREA 3P5BL 2BOXA 1LMJA 2J95B 2KL7A 5JB9E 4BTTA 5JVZA 3QCWA 4YZUB 3NTBA 3POYA 1EPJA 4M11A 3ENSA 1EMNA 2P94L 2Q1JB 2VVVL 2VVUL 2WPJE 1KIGL 4JZEL 5CKMA 5IKVA 1V3XB 5JB8E 5L2ZL 1MOXC 1W7XL 3H5CB 2BMGA 2BZ6L 2VWLL 1F7MA 1LPZA 1P9JA 1PXXA 1IQEL 1IOEL 2XC5L 3F6UL 4BDWA 4ZHAB 4RRXA 1JBUL 2F9BL 1KSNB 1ATBA 1UZQA 1F0SB 5JBBE 3M37L 1XKAL 1CCVA 1NFUB 1Q4GA 2MGPA 1MQ6L 2P3TA 1CEJA 1ZAQA 1XFEA 2YGPA 1JL9A 5KN5C 3TGFA 4Y6DB 1Z6CA 3LC5B 4JYUL 1IP0A 2WFXB 1EPHA 3F1SB 3QMOA 3PGHA 2BOUA 4Y76B 3FBYA 3LTGD 3LTFB 4ISHL 3CS7L 3BT1A 2Y5FL 3HO4A 1JV2B 4TGFA 2Y81B 4XBMA 1DVAL 1IQLL 4RUTA 1IQNL 2P3FL 4C16A 3SOQA 3SOBB 1C5MF 3K9XA 3N8ZA 4A7IA 1B9WA 2XBYL 2VWNL 4RRWA 4Y71B 4X8TL 2BOKL 5COXA 1L5GB 3NTGA 1HT5A 3TBDA 3QH0A 1DX5I 1IQGL 4LORA 3GISX 2XBXL 5EGMB 2P93L 2Y7XB 5F19A 4BDXA 1A3PA 4X8VL 1EPGA 3Q7DA 4YT7L 2VH6B 6COXA 1G1TA 1IQFL 4RS0A 2MHPA 1I0UA 1CX2A 3V64C 3KQEL 1YUFA 4AQTA 2Y5HL 1KLIL 1EZQB 2FLBL 2K2TA 3N8VA 3CENL 1WU1B 2VWOL 4JYVL 3IITB 4LMFA 4Y79B 1J9CL 2VVCK 3KL6B 3M36L 4OTYA 1M1XB 2P3FN 5L2YL 3U73A 1LPKA 2W2NE 1XKBA 4G1MB 1NZIA 1DDXA 1CCFA 3TK5B 4NGAL 2P16L 5IKTA 1DIYA 2Y5GL 1Z6EL 4MMZB 4FM5A 1G2LB 2J4IB 4ZXYL 3CA7A 2OYUP 2WPKE 2WYJB 1U67A 3TH3L 2WFTA 1WHFA 1QFKL 4X8SL 1FFMA 2CJIB 3IJEB 4RRYA 2D1JB 3OLTA 1EAIC 2TGFA 3DEMA 4PH9A 1GK5A 2VJ3A 2Y7ZB 5F1AA 2J94B 2W3KB 2FZZL 2BO2A 1U8CB 2M74A 1NT0A 2BQ6A 4CUDA 1FAKL 3OLUA 1URKA 3HS7A 3ZYGA 2PUQL 1FF7A 2WG4B 3KRKA 5IKRA 5JW1A 3SW2A 4Y7AB 4D0EA 4O02B 5CKNA 5JBCE 1IVOC 3HS6A 1HJ7A 5K0HB 4OTJA 2FLRL 1NQLB 4X8UL 1IQML 1PTHA 3N8YA 1PFXL 2UWLB 2KB9A 2WPME 1K36A 3HPTA 1IQJL 2W26B 4ZAEB 2PR3B 1CVUA 3R05A 3LN0A 2DDUA 1EBVA 4MMYB 3KQBL 2P95L 3MDLA 3NJPC 2W3IB 1YO8A 1XDTR 3ASIA 2J34B 4Z0KB 2XC4L 4E1GA 1HZ8A 2J38B 3MQEA 1CQEA 2G00L 4XL1A 2RA0L 3TZIA 1N1IA 1NPEB 3FFGL 3N8WA 1FJSL 3LC3B 3KCGL 3BT2A 1FAXL 4CUEA 2W2PE 2H9EL 1EMOA 4BTUA 1APOA 1WHEA 2K2SB 2AYLA 2I9BA 1P0SL 1UZPA 4NG9L 1LPGA 2OYEP 1HT8A 1N7DA 2UWOB 3ZYIB 2UWPB 2KV4A 2Y38A 1G2MB 3N8YB 1NFXB 1CVWL 4ISIL 3LAQA 3KQCL 4D0FA 1ATAA 4RRZA 3V65B 2XBVL 2YGOA 1ADXA 1UZJA 4D90A 1COUA 1HX2A 3C9AC 2W2OE 2EI7B 2XBWL 1UZKA 4XLWA 2EI8B 1DQBA 1YUGA 2VWMK 1F7EA 3KK6A 5FDQA 3SOVA 1IQKL
chains in the Genus database with same CATH superfamily
3KQDL 5I46L 1YGCL 1EGFA 1TOZA 3N8WB 1X7AL 3RR3A 2WPIE 4Z0LA 4GU3A 1NFWB 1W8BL 1IGXA 2WPHE 3GCXE 2BOHA 2BQWA 2P3UA 2W2ME 1LQDA 2FLGA 1BF9A 1LMMA 2PHBB 3U7UG 1NFYB 2B7DL 1V1IA 3LN1A 2BQ7A 5IKQA 1G1SA 2RHPA 1IQHL 1IJQA 3GCWE 1TPGA 2J2UB 2WG3C 4MMXB 2W86A 4COXA 2GD4A 1EQHA 1FE2A 1FSBA 1EPIA 4Z6AL 2VH0B 4ZXXL 1MQ5L 2XC0L 3CFWA 1IOXA 5CKQA 1G1QA 3HS5A 4Y7BB 5E8DA 4JZFL 2MGRA 3ZYJB 2RNLA 2WYGB 5L30L 2P26A 1APQA 2Y80B 1IQIL 3TK6B 1IGZA 5JVYA 1OB1C 3HO3A 1YUKB 3FCSB 1HRFA 3HO5A 2Y82B 3ELAL 4O1ZA 3N8XA 4BXWA 2ADXA 1KLOA 1F0RB 1RFNB 4M10A 1PGEA 3EGFA 4CUFA 2JKHL 2FD6A 4YT6L 4BTIA 5CISA 1O5DL 4CSYA 5KIRA 1HCGB 5JBAE 2P28B 1AUTL 3Q3KB 3NT1A 2W2QE 1LK9A 2I9AA 1L3YA 1ATEA 1KLJL 4NA9L 3LIWB 3S6XA 1HAFA 3BPSE 1EQGA 1K37A 1HAEA 2WPLE 4ZH8B 1SZBA 2EI6B 1PRHA 1ATDA 1G1RA 4GU4A 1TLEA 4BXSA 2NPRA 4JZDL 1HREA 3P5BL 2BOXA 1LMJA 2J95B 2KL7A 5JB9E 4BTTA 5JVZA 3QCWA 4YZUB 3NTBA 3POYA 1EPJA 4M11A 3ENSA 1EMNA 2P94L 2Q1JB 2VVVL 2VVUL 2WPJE 1KIGL 2VRSA 4JZEL 5CKMA 5IKVA 1V3XB 5JB8E 5L2ZL 1MOXC 1W7XL 3H5CB 2BMGA 2BZ6L 2VWLL 1F7MA 1LPZA 1P9JA 1PXXA 1IQEL 1IOEL 2XC5L 3F6UL 4BDWA 4ZHAB 2JJLA 4RRXA 1JBUL 2F9BL 1KSNB 1KKEA 1ATBA 1UZQA 1F0SB 5JBBE 3M37L 1XKAL 1CCVA 1NFUB 1Q4GA 2MGPA 1MQ6L 2P3TA 1CEJA 1ZAQA 1XFEA 2YGPA 1JL9A 5KN5C 3TGFA 4Y6DB 1Z6CA 3LC5B 4JYUL 1IP0A 2WFXB 1EPHA 3F1SB 3QMOA 3PGHA 2BOUA 4Y76B 3FBYA 3LTGD 3LTFB 4ISHL 3CS7L 3BT1A 2Y5FL 3HO4A 1JV2B 4TGFA 2Y81B 4XBMA 1DVAL 4A94C 1IQLL 4RUTA 1IQNL 2P3FL 4C16A 3SOQA 3SOBB 1C5MF 3K9XA 3N8ZA 4A7IA 1B9WA 2XBYL 2VWNL 4RRWA 4Y71B 4X8TL 2BOKL 5COXA 1L5GB 3NTGA 1HT5A 2BT8A 3TBDA 3QH0A 1DX5I 1IQGL 4LORA 3GISX 2XBXL 5EGMB 2P93L 2Y7XB 5F19A 4BDXA 1A3PA 4X8VL 1EPGA 3Q7DA 4YT7L 2VH6B 6COXA 1G1TA 1IQFL 4RS0A 2MHPA 1I0UA 1CX2A 3V64C 3KQEL 1YUFA 4AQTA 2Y5HL 1KLIL 1EZQB 2FLBL 2K2TA 3N8VA 3CENL 1WU1B 2VWOL 4JYVL 3IITB 4LMFA 4Y79B 1J9CL 2VVCK 1V1HA 1QIUA 3KL6B 3M36L 4OTYA 1M1XB 2P3FN 5L2YL 3U73A 1LPKA 2W2NE 1XKBA 4G1MB 1NZIA 1DDXA 1CCFA 2KNIA 3TK5B 4NGAL 2P16L 5IKTA 1DIYA 2Y5GL 1Z6EL 4MMZB 4FM5A 2HORA 1G2LB 2J4IB 4ZXYL 3CA7A 2OYUP 2WPKE 2WYJB 1U67A 2YGQA 3TH3L 2WFTA 1WHFA 1QFKL 4X8SL 1FFMA 2CJIB 3IJEB 4RRYA 2D1JB 3OLTA 1EAIC 2TGFA 3DEMA 4PH9A 1GK5A 2VJ3A 2Y7ZB 5F1AA 2J94B 2W3KB 2FZZL 2BO2A 1U8CB 2M74A 1NT0A 2BQ6A 4CUDA 1FAKL 3OLUA 1URKA 3HS7A 3ZYGA 2PUQL 1FF7A 2WG4B 3KRKA 5IKRA 5JW1A 3SW2A 4Y7AB 4D0EA 4O02B 5CKNA 5JBCE 1IVOC 3HS6A 1HJ7A 5K0HB 4OTJA 2FLRL 1NQLB 4X8UL 1IQML 1PTHA 3N8YA 1PFXL 2UWLB 2KB9A 2WPME 1K36A 3HPTA 1IQJL 2W26B 4ZAEB 2PR3B 1CVUA 3R05A 3LN0A 2DDUA 1EBVA 2WZPP 4MMYB 3KQBL 2P95L 3MDLA 3NJPC 2W3IB 1YO8A 1XDTR 3ASIA 2J34B 4Z0KB 2XC4L 4E1GA 1HZ8A 2J38B 3MQEA 1CQEA 2G00L 4XL1A 2RA0L 3TZIA 1N1IA 1NPEB 3FFGL 3N8WA 1FJSL 2BT7A 3LC3B 3KCGL 3BT2A 1FAXL 4CUEA 2W2PE 2H9EL 1EMOA 4BTUA 1APOA 1WHEA 2H9EC 2K2SB 2AYLA 2I9BA 1P0SL 1UZPA 4NG9L 1LPGA 2BSFA 2OYEP 1HT8A 1N7DA 2UWOB 3ZYIB 2UWPB 2KV4A 2Y38A 1G2MB 3N8YB 1NFXB 1CVWL 4ISIL 3LAQA 3KQCL 4D0FA 1ATAA 4RRZA 3V65B 2XBVL 2YGOA 1ADXA 1UZJA 4D90A 1COUA 1HX2A 3C9AC 2W2OE 2EI7B 2XBWL 1UZKA 4XLWA 2EI8B 1DQBA 1YUGA 2VWMK 1F7EA 3KK6A 5FDQA 3SOVA 2HOXA 1IQKL
chains in the Genus database with same CATH topology
3KQDL 5I46L 1YGCL 1EGFA 1TOZA 3N8WB 1X7AL 3RR3A 2WPIE 4Z0LA 1NFWB 1W8BL 1IGXA 2WPHE 3GCXE 2BOHA 2BQWA 2P3UA 2W2ME 1LQDA 2FLGA 1BF9A 1LMMA 2PHBB 3U7UG 1NFYB 2B7DL 3LN1A 2BQ7A 5IKQA 1G1SA 2RHPA 1IQHL 1IJQA 3GCWE 1TPGA 2J2UB 2WG3C 4MMXB 2W86A 4COXA 2GD4A 1EQHA 1FE2A 1FSBA 1EPIA 4Z6AL 2VH0B 4ZXXL 1MQ5L 2XC0L 3CFWA 1IOXA 5CKQA 1G1QA 3HS5A 4Y7BB 5E8DA 4JZFL 2MGRA 3ZYJB 2RNLA 2WYGB 5L30L 2P26A 1APQA 2Y80B 1IQIL 3TK6B 1IGZA 5JVYA 1OB1C 3HO3A 1YUKB 3FCSB 1HRFA 3HO5A 2Y82B 3ELAL 4O1ZA 3N8XA 4BXWA 2ADXA 1KLOA 1F0RB 1RFNB 4M10A 1PGEA 3EGFA 4CUFA 2JKHL 2FD6A 4YT6L 4BTIA 5CISA 1O5DL 4CSYA 5KIRA 1HCGB 5JBAE 2P28B 1AUTL 3Q3KB 3NT1A 2W2QE 2I9AA 1L3YA 1ATEA 1KLJL 4NA9L 3LIWB 3S6XA 1HAFA 3BPSE 1EQGA 1K37A 1HAEA 2WPLE 4ZH8B 1SZBA 2EI6B 1PRHA 1ATDA 1G1RA 1TLEA 4BXSA 2NPRA 4JZDL 1HREA 3P5BL 2BOXA 1LMJA 2J95B 2KL7A 5JB9E 4BTTA 5JVZA 3QCWA 4YZUB 3NTBA 3POYA 1EPJA 4M11A 3ENSA 1EMNA 2P94L 2Q1JB 2VVVL 2VVUL 2WPJE 1KIGL 4JZEL 5CKMA 5IKVA 1V3XB 5JB8E 5L2ZL 1MOXC 1W7XL 3H5CB 2BMGA 2BZ6L 2VWLL 1F7MA 1LPZA 1P9JA 1PXXA 1IQEL 1IOEL 2XC5L 3F6UL 4BDWA 4ZHAB 4RRXA 1JBUL 2F9BL 1KSNB 1ATBA 1UZQA 1F0SB 5JBBE 3M37L 1XKAL 1CCVA 1NFUB 1Q4GA 2MGPA 1MQ6L 2P3TA 1CEJA 1ZAQA 1XFEA 2YGPA 1JL9A 5KN5C 3TGFA 4Y6DB 1Z6CA 3LC5B 4JYUL 1IP0A 2WFXB 1EPHA 3F1SB 3QMOA 3PGHA 2BOUA 4Y76B 3FBYA 3LTGD 3LTFB 4ISHL 3CS7L 3BT1A 2Y5FL 3HO4A 1JV2B 4TGFA 2Y81B 4XBMA 1DVAL 4A94C 1IQLL 4RUTA 1IQNL 2P3FL 4C16A 3SOQA 3SOBB 1C5MF 3K9XA 3N8ZA 4A7IA 1B9WA 2XBYL 2VWNL 4RRWA 4Y71B 4X8TL 2BOKL 5COXA 1L5GB 3NTGA 1HT5A 3TBDA 3QH0A 1DX5I 1IQGL 4LORA 3GISX 2XBXL 5EGMB 2P93L 2Y7XB 5F19A 4BDXA 1A3PA 4X8VL 1EPGA 3Q7DA 4YT7L 2VH6B 6COXA 1G1TA 1IQFL 4RS0A 2MHPA 1I0UA 1CX2A 3V64C 3KQEL 1YUFA 4AQTA 2Y5HL 1KLIL 1EZQB 2FLBL 2K2TA 3N8VA 3CENL 1WU1B 2VWOL 4JYVL 3IITB 4LMFA 4Y79B 1J9CL 2VVCK 3KL6B 3M36L 4OTYA 1M1XB 2P3FN 5L2YL 3U73A 1LPKA 2W2NE 1XKBA 4G1MB 1NZIA 1DDXA 1CCFA 2KNIA 3TK5B 4NGAL 2P16L 5IKTA 1DIYA 2Y5GL 1Z6EL 4MMZB 4FM5A 1G2LB 2J4IB 4ZXYL 3CA7A 2OYUP 2WPKE 2WYJB 1U67A 2YGQA 3TH3L 2WFTA 1WHFA 1QFKL 4X8SL 1FFMA 2CJIB 3IJEB 4RRYA 2D1JB 3OLTA 1EAIC 2TGFA 3DEMA 4PH9A 1GK5A 2VJ3A 2Y7ZB 5F1AA 2J94B 2W3KB 2FZZL 2BO2A 1U8CB 2M74A 1NT0A 2BQ6A 4CUDA 1FAKL 3OLUA 1URKA 3HS7A 3ZYGA 2PUQL 1FF7A 2WG4B 3KRKA 5IKRA 5JW1A 3SW2A 4Y7AB 4D0EA 4O02B 5CKNA 5JBCE 1IVOC 3HS6A 1HJ7A 5K0HB 4OTJA 2FLRL 1NQLB 4X8UL 1IQML 1PTHA 3N8YA 1PFXL 2UWLB 2KB9A 2WPME 1K36A 3HPTA 1IQJL 2W26B 4ZAEB 2PR3B 1CVUA 3R05A 3LN0A 2DDUA 1EBVA 2WZPP 4MMYB 3KQBL 2P95L 3MDLA 3NJPC 2W3IB 1YO8A 1XDTR 3ASIA 2J34B 4Z0KB 2XC4L 4E1GA 1HZ8A 2J38B 3MQEA 1CQEA 2G00L 4XL1A 2RA0L 3TZIA 1N1IA 1NPEB 3FFGL 3N8WA 1FJSL 3LC3B 3KCGL 3BT2A 1FAXL 4CUEA 2W2PE 2H9EL 1EMOA 4BTUA 1APOA 1WHEA 2H9EC 2K2SB 2AYLA 2I9BA 1P0SL 1UZPA 4NG9L 1LPGA 2OYEP 1HT8A 1N7DA 2UWOB 3ZYIB 2UWPB 2KV4A 2Y38A 1G2MB 3N8YB 1NFXB 1CVWL 4ISIL 3LAQA 3KQCL 4D0FA 1ATAA 4RRZA 3V65B 2XBVL 2YGOA 1ADXA 1UZJA 4D90A 1COUA 1HX2A 3C9AC 2W2OE 2EI7B 2XBWL 1UZKA 4XLWA 2EI8B 1DQBA 1YUGA 2VWMK 1F7EA 3KK6A 5FDQA 3SOVA 1IQKL
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3KQD L;  5I46 L;  1YGC L;  1EGF A;  1TOZ A;  3N8W B;  1X7A L;  3RR3 A;  2WPI E;  4Z0L A;  1NFW B;  1W8B L;  1IGX A;  2WPH E;  3GCX E;  2BOH A;  2BQW A;  2P3U A;  2W2M E;  1LQD A;  2FLG A;  1BF9 A;  2PHB B;  3U7U G;  1NFY B;  2B7D L;  3LN1 A;  2BQ7 A;  5IKQ A;  1G1S A;  2RHP A;  1IQH L;  1IJQ A;  3GCW E;  1TPG A;  2J2U B;  2WG3 C;  4MMX B;  2W86 A;  4COX A;  2GD4 A;  1EQH A;  1FE2 A;  1FSB A;  1EPI A;  4Z6A L;  2VH0 B;  4ZXX L;  1MQ5 L;  2XC0 L;  3CFW A;  1IOX A;  5CKQ A;  1G1Q A;  3HS5 A;  4Y7B B;  5E8D A;  4JZF L;  2MGR A;  3ZYJ B;  2RNL A;  2WYG B;  5L30 L;  2P26 A;  1APQ A;  2Y80 B;  1IQI L;  3TK6 B;  1IGZ A;  5JVY A;  1OB1 C;  3HO3 A;  1YUK B;  3FCS B;  1HRF A;  3HO5 A;  2Y82 B;  3ELA L;  4O1Z A;  3N8X A;  4BXW A;  2ADX A;  1KLO A;  1F0R B;  1RFN B;  4M10 A;  1PGE A;  3EGF A;  4CUF A;  2JKH L;  2FD6 A;  4YT6 L;  4BTI A;  5CIS A;  1O5D L;  4CSY A;  5KIR A;  1HCG B;  5JBA E;  2P28 B;  1AUT L;  3Q3K B;  3NT1 A;  2W2Q E;  2I9A A;  1L3Y A;  1ATE A;  1KLJ L;  4NA9 L;  3LIW B;  1HAF A;  3BPS E;  1EQG A;  1K37 A;  1HAE A;  2WPL E;  4ZH8 B;  1SZB A;  2EI6 B;  1PRH A;  1ATD A;  1G1R A;  1TLE A;  4BXS A;  2NPR A;  4JZD L;  1HRE A;  3P5B L;  2BOX A;  1LMJ A;  2J95 B;  2KL7 A;  5JB9 E;  4BTT A;  5JVZ A;  3QCW A;  4YZU B;  3NTB A;  3POY A;  1EPJ A;  4M11 A;  3ENS A;  1EMN A;  2P94 L;  2Q1J B;  2VVV L;  2VVU L;  2WPJ E;  1KIG L;  4JZE L;  5CKM A;  5IKV A;  1V3X B;  5JB8 E;  5L2Z L;  1MOX C;  1W7X L;  3H5C B;  2BMG A;  2BZ6 L;  2VWL L;  1F7M A;  1LPZ A;  1P9J A;  1PXX A;  1IQE L;  1IOE L;  2XC5 L;  3F6U L;  4BDW A;  4ZHA B;  4RRX A;  1JBU L;  2F9B L;  1KSN B;  1ATB A;  1UZQ A;  1F0S B;  5JBB E;  3M37 L;  1XKA L;  1CCV A;  1NFU B;  1Q4G A;  2MGP A;  1MQ6 L;  2P3T A;  1CEJ A;  1ZAQ A;  1XFE A;  2YGP A;  1JL9 A;  5KN5 C;  3TGF A;  4Y6D B;  1Z6C A;  3LC5 B;  4JYU L;  1IP0 A;  2WFX B;  1EPH A;  3F1S B;  3QMO A;  3PGH A;  2BOU A;  4Y76 B;  3FBY A;  3LTG D;  3LTF B;  4ISH L;  3CS7 L;  3BT1 A;  2Y5F L;  3HO4 A;  1JV2 B;  4TGF A;  2Y81 B;  4XBM A;  1DVA L;  1IQL L;  4RUT A;  1IQN L;  2P3F L;  4C16 A;  3SOQ A;  3SOB B;  1C5M F;  3K9X A;  3N8Z A;  4A7I A;  1B9W A;  2XBY L;  2VWN L;  4RRW A;  4Y71 B;  4X8T L;  2BOK L;  5COX A;  1L5G B;  3NTG A;  1HT5 A;  3TBD A;  3QH0 A;  1DX5 I;  1IQG L;  4LOR A;  3GIS X;  2XBX L;  5EGM B;  2P93 L;  2Y7X B;  5F19 A;  4BDX A;  1A3P A;  4X8V L;  1EPG A;  3Q7D A;  4YT7 L;  2VH6 B;  6COX A;  1G1T A;  1IQF L;  4RS0 A;  2MHP A;  1I0U A;  1CX2 A;  3V64 C;  3KQE L;  1YUF A;  4AQT A;  2Y5H L;  1KLI L;  1EZQ B;  2FLB L;  2K2T A;  3N8V A;  3CEN L;  1WU1 B;  2VWO L;  4JYV L;  3IIT B;  4LMF A;  4Y79 B;  1J9C L;  2VVC K;  3KL6 B;  3M36 L;  4OTY A;  1M1X B;  2P3F N;  5L2Y L;  3U73 A;  1LPK A;  2W2N E;  1XKB A;  4G1M B;  1NZI A;  1DDX A;  1CCF A;  3TK5 B;  4NGA L;  2P16 L;  5IKT A;  1DIY A;  2Y5G L;  1Z6E L;  4MMZ B;  4FM5 A;  1G2L B;  2J4I B;  4ZXY L;  3CA7 A;  2OYU P;  2WPK E;  2WYJ B;  1U67 A;  3TH3 L;  2WFT A;  1WHF A;  1QFK L;  4X8S L;  1FFM A;  2CJI B;  3IJE B;  4RRY A;  2D1J B;  3OLT A;  1EAI C;  2TGF A;  3DEM A;  4PH9 A;  1GK5 A;  2VJ3 A;  2Y7Z B;  5F1A A;  2J94 B;  2W3K B;  2FZZ L;  2BO2 A;  1U8C B;  2M74 A;  1NT0 A;  2BQ6 A;  4CUD A;  1FAK L;  3OLU A;  1URK A;  3HS7 A;  3ZYG A;  2PUQ L;  1FF7 A;  2WG4 B;  3KRK A;  5IKR A;  5JW1 A;  3SW2 A;  4Y7A B;  4D0E A;  4O02 B;  5CKN A;  5JBC E;  1IVO C;  3HS6 A;  1HJ7 A;  5K0H B;  4OTJ A;  2FLR L;  1NQL B;  4X8U L;  1IQM L;  1PTH A;  3N8Y A;  1PFX L;  2UWL B;  2KB9 A;  2WPM E;  1K36 A;  3HPT A;  1IQJ L;  2W26 B;  4ZAE B;  2PR3 B;  1CVU A;  3R05 A;  3LN0 A;  2DDU A;  1EBV A;  4MMY B;  3KQB L;  2P95 L;  3MDL A;  3NJP C;  2W3I B;  1YO8 A;  1XDT R;  3ASI A;  2J34 B;  4Z0K B;  2XC4 L;  4E1G A;  1HZ8 A;  2J38 B;  3MQE A;  1CQE A;  2G00 L;  4XL1 A;  2RA0 L;  3TZI A;  1N1I A;  1NPE B;  3FFG L;  3N8W A;  1FJS L;  3LC3 B;  3KCG L;  3BT2 A;  1FAX L;  4CUE A;  2W2P E;  2H9E L;  1EMO A;  4BTU A;  1APO A;  1WHE A;  2K2S B;  2AYL A;  2I9B A;  1P0S L;  1UZP A;  4NG9 L;  1LPG A;  2OYE P;  1HT8 A;  1N7D A;  2UWO B;  3ZYI B;  2UWP B;  2KV4 A;  2Y38 A;  1G2M B;  3N8Y B;  1NFX B;  1CVW L;  4ISI L;  3LAQ A;  3KQC L;  4D0F A;  1ATA A;  4RRZ A;  3V65 B;  2XBV L;  2YGO A;  1ADX A;  1UZJ A;  4D90 A;  1COU A;  1HX2 A;  3C9A C;  2W2O E;  2EI7 B;  2XBW L;  1UZK A;  4XLW A;  2EI8 B;  1DQB A;  1YUG A;  2VWM K;  1F7E A;  3KK6 A;  5FDQ A;  3SOV A;  1IQK L; 
#chains in the Genus database with same CATH topology
 3KQD L;  5I46 L;  1YGC L;  1EGF A;  1TOZ A;  3N8W B;  1X7A L;  3RR3 A;  2WPI E;  4Z0L A;  4GU3 A;  1NFW B;  1W8B L;  1IGX A;  2WPH E;  3GCX E;  2BOH A;  2BQW A;  2P3U A;  2W2M E;  1LQD A;  2FLG A;  1BF9 A;  1LMM A;  2PHB B;  3U7U G;  1NFY B;  2B7D L;  1V1I A;  3LN1 A;  2BQ7 A;  5IKQ A;  1G1S A;  2RHP A;  1IQH L;  1IJQ A;  3GCW E;  1TPG A;  2J2U B;  2WG3 C;  4MMX B;  2W86 A;  4COX A;  2GD4 A;  1EQH A;  1FE2 A;  1FSB A;  1EPI A;  4Z6A L;  2VH0 B;  4ZXX L;  1MQ5 L;  2XC0 L;  3CFW A;  1IOX A;  5CKQ A;  1G1Q A;  3HS5 A;  4Y7B B;  5E8D A;  4JZF L;  2MGR A;  3ZYJ B;  2RNL A;  2WYG B;  5L30 L;  2P26 A;  1APQ A;  2Y80 B;  1IQI L;  3TK6 B;  1IGZ A;  5JVY A;  1OB1 C;  3HO3 A;  1YUK B;  3FCS B;  1HRF A;  3HO5 A;  2Y82 B;  3ELA L;  4O1Z A;  3N8X A;  4BXW A;  2ADX A;  1KLO A;  1F0R B;  1RFN B;  4M10 A;  1PGE A;  3EGF A;  4CUF A;  2JKH L;  2FD6 A;  4YT6 L;  4BTI A;  5CIS A;  1O5D L;  4CSY A;  5KIR A;  1HCG B;  5JBA E;  2P28 B;  1AUT L;  3Q3K B;  3NT1 A;  2W2Q E;  1LK9 A;  2I9A A;  1L3Y A;  1ATE A;  1KLJ L;  4NA9 L;  3LIW B;  3S6X A;  1HAF A;  3BPS E;  1EQG A;  1K37 A;  1HAE A;  2WPL E;  4ZH8 B;  1SZB A;  2EI6 B;  1PRH A;  1ATD A;  1G1R A;  4GU4 A;  1TLE A;  4BXS A;  2NPR A;  4JZD L;  1HRE A;  3P5B L;  2BOX A;  1LMJ A;  2J95 B;  2KL7 A;  5JB9 E;  4BTT A;  5JVZ A;  3QCW A;  4YZU B;  3NTB A;  3POY A;  1EPJ A;  4M11 A;  3ENS A;  1EMN A;  2P94 L;  2Q1J B;  2VVV L;  2VVU L;  2WPJ E;  1KIG L;  2VRS A;  4JZE L;  5CKM A;  5IKV A;  1V3X B;  5JB8 E;  5L2Z L;  1MOX C;  1W7X L;  3H5C B;  2BMG A;  2BZ6 L;  2VWL L;  1F7M A;  1LPZ A;  1P9J A;  1PXX A;  1IQE L;  1IOE L;  2XC5 L;  3F6U L;  4BDW A;  4ZHA B;  2JJL A;  4RRX A;  1JBU L;  2F9B L;  1KSN B;  1KKE A;  1ATB A;  1UZQ A;  1F0S B;  5JBB E;  3M37 L;  1XKA L;  1CCV A;  1NFU B;  1Q4G A;  2MGP A;  1MQ6 L;  2P3T A;  1CEJ A;  1ZAQ A;  1XFE A;  2YGP A;  1JL9 A;  5KN5 C;  3TGF A;  4Y6D B;  1Z6C A;  3LC5 B;  4JYU L;  1IP0 A;  2WFX B;  1EPH A;  3F1S B;  3QMO A;  3PGH A;  2BOU A;  4Y76 B;  3FBY A;  3LTG D;  3LTF B;  4ISH L;  3CS7 L;  3BT1 A;  2Y5F L;  3HO4 A;  1JV2 B;  4TGF A;  2Y81 B;  4XBM A;  1DVA L;  4A94 C;  1IQL L;  4RUT A;  1IQN L;  2P3F L;  4C16 A;  3SOQ A;  3SOB B;  1C5M F;  3K9X A;  3N8Z A;  4A7I A;  1B9W A;  2XBY L;  2VWN L;  4RRW A;  4Y71 B;  4X8T L;  2BOK L;  5COX A;  1L5G B;  3NTG A;  1HT5 A;  2BT8 A;  3TBD A;  3QH0 A;  1DX5 I;  1IQG L;  4LOR A;  3GIS X;  2XBX L;  5EGM B;  2P93 L;  2Y7X B;  5F19 A;  4BDX A;  1A3P A;  4X8V L;  1EPG A;  3Q7D A;  4YT7 L;  2VH6 B;  6COX A;  1G1T A;  1IQF L;  4RS0 A;  2MHP A;  1I0U A;  1CX2 A;  3V64 C;  3KQE L;  1YUF A;  4AQT A;  2Y5H L;  1KLI L;  1EZQ B;  2FLB L;  2K2T A;  3N8V A;  3CEN L;  1WU1 B;  2VWO L;  4JYV L;  3IIT B;  4LMF A;  4Y79 B;  1J9C L;  2VVC K;  1V1H A;  1QIU A;  3KL6 B;  3M36 L;  4OTY A;  1M1X B;  2P3F N;  5L2Y L;  3U73 A;  1LPK A;  2W2N E;  1XKB A;  4G1M B;  1NZI A;  1DDX A;  1CCF A;  2KNI A;  3TK5 B;  4NGA L;  2P16 L;  5IKT A;  1DIY A;  2Y5G L;  1Z6E L;  4MMZ B;  4FM5 A;  2HOR A;  1G2L B;  2J4I B;  4ZXY L;  3CA7 A;  2OYU P;  2WPK E;  2WYJ B;  1U67 A;  2YGQ A;  3TH3 L;  2WFT A;  1WHF A;  1QFK L;  4X8S L;  1FFM A;  2CJI B;  3IJE B;  4RRY A;  2D1J B;  3OLT A;  1EAI C;  2TGF A;  3DEM A;  4PH9 A;  1GK5 A;  2VJ3 A;  2Y7Z B;  5F1A A;  2J94 B;  2W3K B;  2FZZ L;  2BO2 A;  1U8C B;  2M74 A;  1NT0 A;  2BQ6 A;  4CUD A;  1FAK L;  3OLU A;  1URK A;  3HS7 A;  3ZYG A;  2PUQ L;  1FF7 A;  2WG4 B;  3KRK A;  5IKR A;  5JW1 A;  3SW2 A;  4Y7A B;  4D0E A;  4O02 B;  5CKN A;  5JBC E;  1IVO C;  3HS6 A;  1HJ7 A;  5K0H B;  4OTJ A;  2FLR L;  1NQL B;  4X8U L;  1IQM L;  1PTH A;  3N8Y A;  1PFX L;  2UWL B;  2KB9 A;  2WPM E;  1K36 A;  3HPT A;  1IQJ L;  2W26 B;  4ZAE B;  2PR3 B;  1CVU A;  3R05 A;  3LN0 A;  2DDU A;  1EBV A;  2WZP P;  4MMY B;  3KQB L;  2P95 L;  3MDL A;  3NJP C;  2W3I B;  1YO8 A;  1XDT R;  3ASI A;  2J34 B;  4Z0K B;  2XC4 L;  4E1G A;  1HZ8 A;  2J38 B;  3MQE A;  1CQE A;  2G00 L;  4XL1 A;  2RA0 L;  3TZI A;  1N1I A;  1NPE B;  3FFG L;  3N8W A;  1FJS L;  2BT7 A;  3LC3 B;  3KCG L;  3BT2 A;  1FAX L;  4CUE A;  2W2P E;  2H9E L;  1EMO A;  4BTU A;  1APO A;  1WHE A;  2H9E C;  2K2S B;  2AYL A;  2I9B A;  1P0S L;  1UZP A;  4NG9 L;  1LPG A;  2BSF A;  2OYE P;  1HT8 A;  1N7D A;  2UWO B;  3ZYI B;  2UWP B;  2KV4 A;  2Y38 A;  1G2M B;  3N8Y B;  1NFX B;  1CVW L;  4ISI L;  3LAQ A;  3KQC L;  4D0F A;  1ATA A;  4RRZ A;  3V65 B;  2XBV L;  2YGO A;  1ADX A;  1UZJ A;  4D90 A;  1COU A;  1HX2 A;  3C9A C;  2W2O E;  2EI7 B;  2XBW L;  1UZK A;  4XLW A;  2EI8 B;  1DQB A;  1YUG A;  2VWM K;  1F7E A;  3KK6 A;  5FDQ A;  3SOV A;  2HOX A;  1IQK L; 
#chains in the Genus database with same CATH homology
 3KQD L;  5I46 L;  1YGC L;  1EGF A;  1TOZ A;  3N8W B;  1X7A L;  3RR3 A;  2WPI E;  4Z0L A;  1NFW B;  1W8B L;  1IGX A;  2WPH E;  3GCX E;  2BOH A;  2BQW A;  2P3U A;  2W2M E;  1LQD A;  2FLG A;  1BF9 A;  1LMM A;  2PHB B;  3U7U G;  1NFY B;  2B7D L;  3LN1 A;  2BQ7 A;  5IKQ A;  1G1S A;  2RHP A;  1IQH L;  1IJQ A;  3GCW E;  1TPG A;  2J2U B;  2WG3 C;  4MMX B;  2W86 A;  4COX A;  2GD4 A;  1EQH A;  1FE2 A;  1FSB A;  1EPI A;  4Z6A L;  2VH0 B;  4ZXX L;  1MQ5 L;  2XC0 L;  3CFW A;  1IOX A;  5CKQ A;  1G1Q A;  3HS5 A;  4Y7B B;  5E8D A;  4JZF L;  2MGR A;  3ZYJ B;  2RNL A;  2WYG B;  5L30 L;  2P26 A;  1APQ A;  2Y80 B;  1IQI L;  3TK6 B;  1IGZ A;  5JVY A;  1OB1 C;  3HO3 A;  1YUK B;  3FCS B;  1HRF A;  3HO5 A;  2Y82 B;  3ELA L;  4O1Z A;  3N8X A;  4BXW A;  2ADX A;  1KLO A;  1F0R B;  1RFN B;  4M10 A;  1PGE A;  3EGF A;  4CUF A;  2JKH L;  2FD6 A;  4YT6 L;  4BTI A;  5CIS A;  1O5D L;  4CSY A;  5KIR A;  1HCG B;  5JBA E;  2P28 B;  1AUT L;  3Q3K B;  3NT1 A;  2W2Q E;  2I9A A;  1L3Y A;  1ATE A;  1KLJ L;  4NA9 L;  3LIW B;  3S6X A;  1HAF A;  3BPS E;  1EQG A;  1K37 A;  1HAE A;  2WPL E;  4ZH8 B;  1SZB A;  2EI6 B;  1PRH A;  1ATD A;  1G1R A;  1TLE A;  4BXS A;  2NPR A;  4JZD L;  1HRE A;  3P5B L;  2BOX A;  1LMJ A;  2J95 B;  2KL7 A;  5JB9 E;  4BTT A;  5JVZ A;  3QCW A;  4YZU B;  3NTB A;  3POY A;  1EPJ A;  4M11 A;  3ENS A;  1EMN A;  2P94 L;  2Q1J B;  2VVV L;  2VVU L;  2WPJ E;  1KIG L;  4JZE L;  5CKM A;  5IKV A;  1V3X B;  5JB8 E;  5L2Z L;  1MOX C;  1W7X L;  3H5C B;  2BMG A;  2BZ6 L;  2VWL L;  1F7M A;  1LPZ A;  1P9J A;  1PXX A;  1IQE L;  1IOE L;  2XC5 L;  3F6U L;  4BDW A;  4ZHA B;  4RRX A;  1JBU L;  2F9B L;  1KSN B;  1ATB A;  1UZQ A;  1F0S B;  5JBB E;  3M37 L;  1XKA L;  1CCV A;  1NFU B;  1Q4G A;  2MGP A;  1MQ6 L;  2P3T A;  1CEJ A;  1ZAQ A;  1XFE A;  2YGP A;  1JL9 A;  5KN5 C;  3TGF A;  4Y6D B;  1Z6C A;  3LC5 B;  4JYU L;  1IP0 A;  2WFX B;  1EPH A;  3F1S B;  3QMO A;  3PGH A;  2BOU A;  4Y76 B;  3FBY A;  3LTG D;  3LTF B;  4ISH L;  3CS7 L;  3BT1 A;  2Y5F L;  3HO4 A;  1JV2 B;  4TGF A;  2Y81 B;  4XBM A;  1DVA L;  4A94 C;  1IQL L;  4RUT A;  1IQN L;  2P3F L;  4C16 A;  3SOQ A;  3SOB B;  1C5M F;  3K9X A;  3N8Z A;  4A7I A;  1B9W A;  2XBY L;  2VWN L;  4RRW A;  4Y71 B;  4X8T L;  2BOK L;  5COX A;  1L5G B;  3NTG A;  1HT5 A;  3TBD A;  3QH0 A;  1DX5 I;  1IQG L;  4LOR A;  3GIS X;  2XBX L;  5EGM B;  2P93 L;  2Y7X B;  5F19 A;  4BDX A;  1A3P A;  4X8V L;  1EPG A;  3Q7D A;  4YT7 L;  2VH6 B;  6COX A;  1G1T A;  1IQF L;  4RS0 A;  2MHP A;  1I0U A;  1CX2 A;  3V64 C;  3KQE L;  1YUF A;  4AQT A;  2Y5H L;  1KLI L;  1EZQ B;  2FLB L;  2K2T A;  3N8V A;  3CEN L;  1WU1 B;  2VWO L;  4JYV L;  3IIT B;  4LMF A;  4Y79 B;  1J9C L;  2VVC K;  3KL6 B;  3M36 L;  4OTY A;  1M1X B;  2P3F N;  5L2Y L;  3U73 A;  1LPK A;  2W2N E;  1XKB A;  4G1M B;  1NZI A;  1DDX A;  1CCF A;  2KNI A;  3TK5 B;  4NGA L;  2P16 L;  5IKT A;  1DIY A;  2Y5G L;  1Z6E L;  4MMZ B;  4FM5 A;  1G2L B;  2J4I B;  4ZXY L;  3CA7 A;  2OYU P;  2WPK E;  2WYJ B;  1U67 A;  2YGQ A;  3TH3 L;  2WFT A;  1WHF A;  1QFK L;  4X8S L;  1FFM A;  2CJI B;  3IJE B;  4RRY A;  2D1J B;  3OLT A;  1EAI C;  2TGF A;  3DEM A;  4PH9 A;  1GK5 A;  2VJ3 A;  2Y7Z B;  5F1A A;  2J94 B;  2W3K B;  2FZZ L;  2BO2 A;  1U8C B;  2M74 A;  1NT0 A;  2BQ6 A;  4CUD A;  1FAK L;  3OLU A;  1URK A;  3HS7 A;  3ZYG A;  2PUQ L;  1FF7 A;  2WG4 B;  3KRK A;  5IKR A;  5JW1 A;  3SW2 A;  4Y7A B;  4D0E A;  4O02 B;  5CKN A;  5JBC E;  1IVO C;  3HS6 A;  1HJ7 A;  5K0H B;  4OTJ A;  2FLR L;  1NQL B;  4X8U L;  1IQM L;  1PTH A;  3N8Y A;  1PFX L;  2UWL B;  2KB9 A;  2WPM E;  1K36 A;  3HPT A;  1IQJ L;  2W26 B;  4ZAE B;  2PR3 B;  1CVU A;  3R05 A;  3LN0 A;  2DDU A;  1EBV A;  2WZP P;  4MMY B;  3KQB L;  2P95 L;  3MDL A;  3NJP C;  2W3I B;  1YO8 A;  1XDT R;  3ASI A;  2J34 B;  4Z0K B;  2XC4 L;  4E1G A;  1HZ8 A;  2J38 B;  3MQE A;  1CQE A;  2G00 L;  4XL1 A;  2RA0 L;  3TZI A;  1N1I A;  1NPE B;  3FFG L;  3N8W A;  1FJS L;  3LC3 B;  3KCG L;  3BT2 A;  1FAX L;  4CUE A;  2W2P E;  2H9E L;  1EMO A;  4BTU A;  1APO A;  1WHE A;  2H9E C;  2K2S B;  2AYL A;  2I9B A;  1P0S L;  1UZP A;  4NG9 L;  1LPG A;  2OYE P;  1HT8 A;  1N7D A;  2UWO B;  3ZYI B;  2UWP B;  2KV4 A;  2Y38 A;  1G2M B;  3N8Y B;  1NFX B;  1CVW L;  4ISI L;  3LAQ A;  3KQC L;  4D0F A;  1ATA A;  4RRZ A;  3V65 B;  2XBV L;  2YGO A;  1ADX A;  1UZJ A;  4D90 A;  1COU A;  1HX2 A;  3C9A C;  2W2O E;  2EI7 B;  2XBW L;  1UZK A;  4XLW A;  2EI8 B;  1DQB A;  1YUG A;  2VWM K;  1F7E A;  3KK6 A;  5FDQ A;  3SOV A;  1IQK L; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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