5L2ZL

Factor viia in complex with the inhibitor 1-[(2r,15r)-2-[(1-amino-4-fluoroisoquinolin-6-yl)amino]-4,15,17-trimethyl-3,12-dioxo-13-oxa-4,11-diazatricyclo[14.2.2.1~6,10~]henicosa-1(18),6(21),7,9,16,19-hexaen-7-yl]cyclohexane-1-carboxylic acid
Total Genus 13
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
13
sequence length
58
structure length
58
Chain Sequence
DQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILEKR
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Synthesis and P1' SAR exploration of potent macrocyclic tissue factor-factor VIIa inhibitors.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Homo sapiens
molecule keywords Coagulation factor VII (Heavy Chain)
total genus 13
structure length 58
sequence length 58
ec nomenclature ec 3.4.21.21: Coagulation factor VIIa.
pdb deposition date 2016-08-02
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.25.10 Mainly Beta Ribbon Laminin Laminin 5l2zL00
4Z0KB 1ZAQA 2WPLE 1F7MA 4ZXYL 2UWOB 1DDXA 1NFUB 1PGEA 2J34B 2J38B 2D1JB 2RNLA 5CISA 2RA0L 1IGXA 1G2LB 3LC5B 4AQTA 4MMYB 4Z6AL 1G1TA 2WYJB 3ZYGA 1IVOC 2P3TA 1M1XB 2FLGA 1L3YA 2MHPA 4RUTA 5I46L 2VWOL 2XC5L 2WYGB 1HT5A 3HO3A 4YT7L 1HJ7A 5FDQA 3HO5A 1XKBA 2BMGA 3RR3A 1PRHA 1CCFA 2WPME 5CKQA 3C9AC 4LORA 3GCXE 1EQGA 3DEMA 2W3IB 5JB9E 1B9WA 1GK5A 2YGOA 3N8WB 1XFEA 4M10A 3N8YA 4CSYA 3CENL 1G2MB 2DDUA 2WFXB 2P3UA 4X8SL 1SZBA 4CUFA 2G00L 4X8VL 1F0SB 1TLEA 5JW1A 2VWNL 4MMXB 1ATAA 4M11A 1APQA 1NFYB 2P3FL 2J95B 3K9XA 4BDXA 2K2TA 4CUEA 4JZFL 1X7AL 1EMOA 1ATDA 1TOZA 1HZ8A 4BXSA 5E8DA 3ENSA 1EPHA 1DVAL 1IOEL 2FLRL 1Q4GA 2W2OE 2W86A 4ZAEB 3U7UG 4RS0A 4Y6DB 3KCGL 3TK6B 1IQLL 2H9EL 2XBWL 2VH0B 5EGMB 1MQ6L 1Z6EL 2VVUL 1IP0A 1O5DL 1K36A 4Z0LA 1LPGA 2FLBL 2J4IB 5JB8E 3BT2A 4XLWA 3SW2A 1DIYA 3GISX 1TPGA 1NT0A 1XKAL 2VVVL 2P95L 2WPJE 3TZIA 1YO8A 4FM5A 5JBBE 5L2YL 2XBYL 3LC3B 4NG9L 1MQ5L 3SOBB 2ADXA 2BZ6L 1JBUL 2BQ6A 4JZDL 3FFGL 2OYUP 3TGFA 4JZEL 3HPTA 2KV4A 2BOHA 3CA7A 3N8ZA 2W26B 1FJSL 1PXXA 1HT8A 2MGRA 3LIWB 4OTYA 2UWLB 1PTHA 1UZKA 5IKRA 4D90A 1I0UA 2RHPA 1CEJA 2W2NE 1LPKA 1FAXL 4RRYA 1OB1C 2W2ME 1YUKB 3HS6A 1KIGL 3V65B 4YZUB 1NFXB 4PH9A 2P93L 1WHFA 2I9AA 3MQEA 1COUA 4D0FA 1UZPA 4CUDA 2Q1JB 4OTJA 3V64C 2AYLA 2XC0L 2Y5HL 2BOUA 3QMOA 1W8BL 1EBVA 4X8TL 4RRZA 1AUTL 4XBMA 1HAFA 1Z6CA 3EGFA 2EI7B 2CJIB 2P94L 2VH6B 1IQJL 1IGZA 4BTTA 2P16L 2FD6A 4Y7BB 2XBXL 1V3XB 3KQBL 4TGFA 4BTUA 1EQHA 1LPZA 1APOA 3NTBA 3KK6A 1MOXC 2F9BL 3KRKA 4RRXA 5L30L 1W7XL 3NJPC 1PFXL 1UZQA 3N8VA 1G1SA 1FSBA 5IKVA 1YUGA 1IJQA 1IQEL 2EI6B 3OLTA 5CKNA 2K2SB 1CVUA 5F1AA 1FAKL 1IQNL 1KLJL 4BDWA 2PHBB 1G1RA 1NQLB 3MDLA 2OYEP 2WG3C 4JYUL 2Y7ZB 4XL1A 1CVWL 3POYA 1EAIC 3ASIA 4Y79B 3GCWE 3N8WA 1IQKL 1J9CL 4NA9L 3ZYJB 4ZHAB 2Y82B 2XBVL 1IQHL 3SOVA 1L5GB 1KLIL 2JKHL 1CQEA 3OLUA 2J94B 1XDTR 1RFNB 4NGAL 2EI8B 3IJEB 3SOQA 3FCSB 1HRFA 1YGCL 3HS5A 1U8CB 5JBAE 1LQDA 4D0EA 1HX2A 5KIRA 1QFKL 2UWPB 1YUFA 4YT6L 3NT1A 2Y5GL 1EZQB 5IKTA 1N7DA 1UZJA 3M36L 3KQEL 4O1ZA 3N8YB 1A3PA 1P0SL 3CFWA 1N1IA 1EPIA 5JBCE 5COXA 5JVYA 3KQDL 5CKMA 2WPKE 3QCWA 2Y7XB 3U73A 4ISIL 1U67A 3BPSE 3N8XA 4RRWA 4X8UL 1KLOA 3KL6B 1KSNB 5IKQA 2P28B 3QH0A 1HAEA 2BQWA 4A7IA 3F6UL 2VWLL 1HCGB 1P9JA 2WPIE 5K0HB 3CS7L 2I9BA 2GD4A 2W3KB 3ELAL 4MMZB 2P3FN 2YGPA 3H5CB 2BOKL 3HO4A 1JL9A 1URKA 3R05A 2PUQL 4BXWA 2PR3B 2Y80B 1K37A 2VWMK 1EPJA 2Y5FL 4COXA 4ISHL 1DX5I 4BTIA 5JVZA 2Y38A 2WFTA 2BQ7A 4O02B 2XC4L 3LN0A 3TH3L 5L2ZL 1CX2A 1WHEA 1G1QA 1IQIL 4ZXXL 3LTGD 3Q7DA 2FZZL 3P5BL 2VJ3A 1FFMA 1F0RB 3IITB 6COXA 1IQGL 2VVCK 2W2PE 1EPGA 3ZYIB 1IOXA 3M37L 1CCVA 1ATEA 5F19A 2TGFA 1DQBA 4C16A 2J2UB 1FF7A 1IQFL 4ZH8B 3Q3KB 1C5MF 1EMNA 3LTFB 3PGHA 1NPEB 1FE2A 2KB9A 4E1GA 4Y7AB 2NPRA 2BO2A 2W2QE 1NFWB 3NTGA 5KN5C 2BOXA 2MGPA 4LMFA 3BT1A 3FBYA 1F7EA 3LAQA 3F1SB 1NZIA 2M74A 1HREA 1LMJA 2KL7A 3HS7A 2B7DL 4Y71B 1ADXA 3KQCL 1BF9A 4JYVL 4G1MB 1ATBA 2WPHE 1IQML 2WG4B 3TK5B 1EGFA 3LN1A 1WU1B 2Y81B 4Y76B 2P26A 3TBDA 1JV2B
chains in the Genus database with same CATH superfamily
4Z0KB 1ZAQA 2WPLE 1F7MA 4ZXYL 2UWOB 1DDXA 1NFUB 2YGQA 1PGEA 2J34B 2J38B 2D1JB 2RNLA 5CISA 2RA0L 1IGXA 1G2LB 3LC5B 4AQTA 4MMYB 4Z6AL 1G1TA 2WYJB 3ZYGA 1IVOC 2P3TA 1M1XB 2FLGA 1L3YA 2MHPA 1LK9A 4RUTA 5I46L 2VWOL 2XC5L 2WYGB 1HT5A 3HO3A 4YT7L 4GU4A 1HJ7A 5FDQA 3HO5A 1XKBA 2BMGA 3RR3A 1PRHA 1CCFA 2WPME 5CKQA 3C9AC 4LORA 3GCXE 1EQGA 3DEMA 2W3IB 5JB9E 1B9WA 1GK5A 2YGOA 3N8WB 1XFEA 4M10A 3N8YA 4CSYA 3CENL 1G2MB 2DDUA 2WFXB 2P3UA 4X8SL 1SZBA 4CUFA 2G00L 4X8VL 1F0SB 1TLEA 1V1IA 5JW1A 2VWNL 4MMXB 1QIUA 1ATAA 4M11A 1APQA 1NFYB 2BT8A 2P3FL 2J95B 3K9XA 4BDXA 2K2TA 4CUEA 4JZFL 1X7AL 1EMOA 1ATDA 1TOZA 1HZ8A 4BXSA 5E8DA 3ENSA 1EPHA 1DVAL 1IOEL 2FLRL 1Q4GA 2W2OE 2W86A 4ZAEB 3U7UG 4RS0A 4Y6DB 3KCGL 3TK6B 2HOXA 1IQLL 2H9EL 2XBWL 2VH0B 5EGMB 1MQ6L 1Z6EL 2VVUL 1IP0A 1O5DL 1K36A 4Z0LA 1LPGA 2FLBL 2J4IB 5JB8E 3BT2A 1KKEA 4XLWA 3SW2A 1DIYA 3GISX 1TPGA 1NT0A 1XKAL 2VVVL 2P95L 2WPJE 2BT7A 3TZIA 1YO8A 4FM5A 5JBBE 5L2YL 2XBYL 3LC3B 4NG9L 1MQ5L 3SOBB 2ADXA 4A94C 2BZ6L 1JBUL 2BQ6A 4JZDL 3FFGL 2OYUP 3TGFA 4JZEL 3HPTA 2KV4A 2BOHA 3CA7A 3N8ZA 2W26B 1FJSL 1PXXA 1HT8A 2MGRA 3LIWB 1V1HA 4OTYA 2UWLB 1PTHA 1UZKA 5IKRA 4D90A 1I0UA 2RHPA 1CEJA 2W2NE 1LPKA 1FAXL 4RRYA 1OB1C 2W2ME 1YUKB 3HS6A 1KIGL 3V65B 4YZUB 1NFXB 4PH9A 2P93L 1WHFA 2I9AA 3MQEA 1COUA 2JJLA 4D0FA 1UZPA 4CUDA 2WZPP 2Q1JB 4OTJA 3V64C 2AYLA 2XC0L 2Y5HL 2BOUA 3QMOA 1W8BL 1EBVA 4X8TL 4RRZA 1AUTL 4XBMA 1HAFA 1Z6CA 3EGFA 2EI7B 2CJIB 2P94L 2VH6B 1IQJL 1IGZA 4BTTA 2P16L 2FD6A 4Y7BB 2XBXL 1V3XB 3KQBL 4TGFA 4BTUA 1EQHA 1LPZA 1APOA 3KK6A 3NTBA 1MOXC 2F9BL 3KRKA 4RRXA 5L30L 1W7XL 3NJPC 1PFXL 1UZQA 3N8VA 1G1SA 1FSBA 5IKVA 1YUGA 1IJQA 1IQEL 2EI6B 3OLTA 3S6XA 5CKNA 2K2SB 1CVUA 5F1AA 1FAKL 1IQNL 1KLJL 4BDWA 2PHBB 1G1RA 1NQLB 3MDLA 2OYEP 2WG3C 4JYUL 2Y7ZB 4XL1A 1CVWL 3POYA 1EAIC 3ASIA 4Y79B 3GCWE 2VRSA 3N8WA 1IQKL 1J9CL 4NA9L 3ZYJB 4ZHAB 2Y82B 2XBVL 1IQHL 3SOVA 1L5GB 1KLIL 2JKHL 1CQEA 3OLUA 2J94B 1XDTR 1RFNB 4NGAL 2EI8B 3IJEB 3SOQA 3FCSB 1HRFA 1YGCL 3HS5A 1U8CB 5JBAE 1LQDA 4D0EA 1HX2A 5KIRA 1QFKL 2UWPB 1YUFA 4YT6L 3NT1A 2Y5GL 1EZQB 5IKTA 1N7DA 1UZJA 3M36L 3KQEL 4O1ZA 3N8YB 1A3PA 1P0SL 3CFWA 1N1IA 1EPIA 5JBCE 5COXA 5JVYA 2HORA 4GU3A 3KQDL 5CKMA 2WPKE 3QCWA 2Y7XB 3U73A 4ISIL 1U67A 3BPSE 3N8XA 4RRWA 4X8UL 1KLOA 3KL6B 1KSNB 5IKQA 2P28B 3QH0A 1HAEA 2BQWA 4A7IA 3F6UL 2VWLL 1HCGB 1P9JA 2WPIE 5K0HB 3CS7L 2I9BA 2GD4A 2W3KB 3ELAL 4MMZB 2P3FN 2YGPA 3H5CB 2BOKL 3HO4A 1JL9A 1URKA 3R05A 2PUQL 4BXWA 2PR3B 2Y80B 1K37A 2VWMK 1EPJA 2Y5FL 4COXA 4ISHL 1DX5I 4BTIA 5JVZA 2Y38A 2WFTA 2BQ7A 4O02B 2XC4L 3LN0A 3TH3L 5L2ZL 1CX2A 1WHEA 1G1QA 1IQIL 4ZXXL 3LTGD 3Q7DA 2FZZL 3P5BL 2VJ3A 1FFMA 1F0RB 3IITB 6COXA 1IQGL 2VVCK 2W2PE 1EPGA 3ZYIB 1IOXA 2KNIA 3M37L 1CCVA 1ATEA 5F19A 2TGFA 1DQBA 4C16A 2J2UB 1FF7A 1IQFL 4ZH8B 3Q3KB 1C5MF 1EMNA 3LTFB 3PGHA 1NPEB 1FE2A 2KB9A 4E1GA 4Y7AB 2NPRA 2BO2A 2W2QE 1NFWB 3NTGA 5KN5C 2BOXA 2MGPA 4LMFA 1LMMA 2H9EC 3BT1A 3FBYA 1F7EA 3LAQA 3F1SB 1NZIA 2M74A 1HREA 1LMJA 2KL7A 3HS7A 2B7DL 4Y71B 1ADXA 3KQCL 1BF9A 4JYVL 4G1MB 1ATBA 2WPHE 1IQML 2WG4B 3TK5B 1EGFA 3LN1A 1WU1B 2Y81B 4Y76B 2BSFA 2P26A 3TBDA 1JV2B
chains in the Genus database with same CATH topology
4Z0KB 1ZAQA 2WPLE 1F7MA 4ZXYL 2UWOB 1DDXA 1NFUB 2YGQA 1PGEA 2J34B 2J38B 2D1JB 2RNLA 5CISA 2RA0L 1IGXA 1G2LB 3LC5B 4AQTA 4MMYB 4Z6AL 1G1TA 2WYJB 3ZYGA 1IVOC 2P3TA 1M1XB 2FLGA 1L3YA 2MHPA 4RUTA 5I46L 2VWOL 2XC5L 2WYGB 1HT5A 3HO3A 4YT7L 1HJ7A 5FDQA 3HO5A 1XKBA 2BMGA 3RR3A 1PRHA 1CCFA 2WPME 5CKQA 3C9AC 4LORA 3GCXE 1EQGA 3DEMA 2W3IB 5JB9E 1B9WA 1GK5A 2YGOA 3N8WB 1XFEA 4M10A 3N8YA 4CSYA 3CENL 1G2MB 2DDUA 2WFXB 2P3UA 4X8SL 1SZBA 4CUFA 2G00L 4X8VL 1F0SB 1TLEA 5JW1A 2VWNL 4MMXB 1ATAA 4M11A 1APQA 1NFYB 2P3FL 2J95B 3K9XA 4BDXA 2K2TA 4CUEA 4JZFL 1X7AL 1EMOA 1ATDA 1TOZA 1HZ8A 4BXSA 5E8DA 3ENSA 1EPHA 1DVAL 1IOEL 2FLRL 1Q4GA 2W2OE 2W86A 4ZAEB 3U7UG 4RS0A 4Y6DB 3KCGL 3TK6B 1IQLL 2H9EL 2XBWL 2VH0B 5EGMB 1MQ6L 1Z6EL 2VVUL 1IP0A 1O5DL 1K36A 4Z0LA 1LPGA 2FLBL 2J4IB 5JB8E 3BT2A 4XLWA 3SW2A 1DIYA 3GISX 1TPGA 1NT0A 1XKAL 2VVVL 2P95L 2WPJE 3TZIA 1YO8A 4FM5A 5JBBE 5L2YL 2XBYL 3LC3B 4NG9L 1MQ5L 3SOBB 2ADXA 4A94C 2BZ6L 1JBUL 2BQ6A 4JZDL 3FFGL 2OYUP 3TGFA 4JZEL 3HPTA 2KV4A 2BOHA 3CA7A 3N8ZA 2W26B 1FJSL 1PXXA 1HT8A 2MGRA 3LIWB 4OTYA 2UWLB 1PTHA 1UZKA 5IKRA 4D90A 1I0UA 2RHPA 1CEJA 2W2NE 1LPKA 1FAXL 4RRYA 1OB1C 2W2ME 1YUKB 3HS6A 1KIGL 3V65B 4YZUB 1NFXB 4PH9A 2P93L 1WHFA 2I9AA 3MQEA 1COUA 4D0FA 1UZPA 4CUDA 2WZPP 2Q1JB 4OTJA 3V64C 2AYLA 2XC0L 2Y5HL 2BOUA 3QMOA 1W8BL 1EBVA 4X8TL 4RRZA 1AUTL 4XBMA 1HAFA 1Z6CA 3EGFA 2EI7B 2CJIB 2P94L 2VH6B 1IQJL 1IGZA 4BTTA 2P16L 2FD6A 4Y7BB 2XBXL 1V3XB 3KQBL 4TGFA 4BTUA 1EQHA 1LPZA 1APOA 3KK6A 3NTBA 1MOXC 2F9BL 3KRKA 4RRXA 5L30L 1W7XL 3NJPC 1PFXL 1UZQA 3N8VA 1G1SA 1FSBA 5IKVA 1YUGA 1IJQA 1IQEL 2EI6B 3OLTA 3S6XA 5CKNA 2K2SB 1CVUA 5F1AA 1FAKL 1IQNL 1KLJL 4BDWA 2PHBB 1G1RA 1NQLB 3MDLA 2OYEP 2WG3C 4JYUL 2Y7ZB 4XL1A 1CVWL 3POYA 1EAIC 3ASIA 4Y79B 3GCWE 3N8WA 1IQKL 1J9CL 4NA9L 3ZYJB 4ZHAB 2Y82B 2XBVL 1IQHL 3SOVA 1L5GB 1KLIL 2JKHL 1CQEA 3OLUA 2J94B 1XDTR 1RFNB 4NGAL 2EI8B 3IJEB 3SOQA 3FCSB 1HRFA 1YGCL 3HS5A 1U8CB 5JBAE 1LQDA 4D0EA 1HX2A 5KIRA 1QFKL 2UWPB 1YUFA 4YT6L 3NT1A 2Y5GL 1EZQB 5IKTA 1N7DA 1UZJA 3M36L 3KQEL 4O1ZA 3N8YB 1A3PA 1P0SL 3CFWA 1N1IA 1EPIA 5JBCE 5COXA 5JVYA 3KQDL 5CKMA 2WPKE 3QCWA 2Y7XB 3U73A 4ISIL 1U67A 3BPSE 3N8XA 4RRWA 4X8UL 1KLOA 3KL6B 1KSNB 5IKQA 2P28B 3QH0A 1HAEA 2BQWA 4A7IA 3F6UL 2VWLL 1HCGB 1P9JA 2WPIE 5K0HB 3CS7L 2I9BA 2GD4A 2W3KB 3ELAL 4MMZB 2P3FN 2YGPA 3H5CB 2BOKL 3HO4A 1JL9A 1URKA 3R05A 2PUQL 4BXWA 2PR3B 2Y80B 1K37A 2VWMK 1EPJA 2Y5FL 4COXA 4ISHL 1DX5I 4BTIA 5JVZA 2Y38A 2WFTA 2BQ7A 4O02B 2XC4L 3LN0A 3TH3L 5L2ZL 1CX2A 1WHEA 1G1QA 1IQIL 4ZXXL 3LTGD 3Q7DA 2FZZL 3P5BL 2VJ3A 1FFMA 1F0RB 3IITB 6COXA 1IQGL 2VVCK 2W2PE 1EPGA 3ZYIB 1IOXA 2KNIA 3M37L 1CCVA 1ATEA 5F19A 2TGFA 1DQBA 4C16A 2J2UB 1FF7A 1IQFL 4ZH8B 3Q3KB 1C5MF 1EMNA 3LTFB 3PGHA 1NPEB 1FE2A 2KB9A 4E1GA 4Y7AB 2NPRA 2BO2A 2W2QE 1NFWB 3NTGA 5KN5C 2BOXA 2MGPA 4LMFA 1LMMA 2H9EC 3BT1A 3FBYA 1F7EA 3LAQA 3F1SB 1NZIA 2M74A 1HREA 1LMJA 2KL7A 3HS7A 2B7DL 4Y71B 1ADXA 3KQCL 1BF9A 4JYVL 4G1MB 1ATBA 2WPHE 1IQML 2WG4B 3TK5B 1EGFA 3LN1A 1WU1B 2Y81B 4Y76B 2P26A 3TBDA 1JV2B
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4Z0K B;  1ZAQ A;  2WPL E;  1F7M A;  4ZXY L;  2UWO B;  1DDX A;  1NFU B;  1PGE A;  2J34 B;  2J38 B;  2D1J B;  2RNL A;  5CIS A;  2RA0 L;  1IGX A;  1G2L B;  3LC5 B;  4AQT A;  4MMY B;  4Z6A L;  1G1T A;  2WYJ B;  3ZYG A;  1IVO C;  2P3T A;  1M1X B;  2FLG A;  1L3Y A;  2MHP A;  4RUT A;  5I46 L;  2VWO L;  2XC5 L;  2WYG B;  1HT5 A;  3HO3 A;  4YT7 L;  1HJ7 A;  5FDQ A;  3HO5 A;  1XKB A;  2BMG A;  3RR3 A;  1PRH A;  1CCF A;  2WPM E;  5CKQ A;  3C9A C;  4LOR A;  3GCX E;  1EQG A;  3DEM A;  2W3I B;  5JB9 E;  1B9W A;  1GK5 A;  2YGO A;  3N8W B;  1XFE A;  4M10 A;  3N8Y A;  4CSY A;  3CEN L;  1G2M B;  2DDU A;  2WFX B;  2P3U A;  4X8S L;  1SZB A;  4CUF A;  2G00 L;  4X8V L;  1F0S B;  1TLE A;  5JW1 A;  2VWN L;  4MMX B;  1ATA A;  4M11 A;  1APQ A;  1NFY B;  2P3F L;  2J95 B;  3K9X A;  4BDX A;  2K2T A;  4CUE A;  4JZF L;  1X7A L;  1EMO A;  1ATD A;  1TOZ A;  1HZ8 A;  4BXS A;  5E8D A;  3ENS A;  1EPH A;  1DVA L;  1IOE L;  2FLR L;  1Q4G A;  2W2O E;  2W86 A;  4ZAE B;  3U7U G;  4RS0 A;  4Y6D B;  3KCG L;  3TK6 B;  1IQL L;  2H9E L;  2XBW L;  2VH0 B;  5EGM B;  1MQ6 L;  1Z6E L;  2VVU L;  1IP0 A;  1O5D L;  1K36 A;  4Z0L A;  1LPG A;  2FLB L;  2J4I B;  5JB8 E;  3BT2 A;  4XLW A;  3SW2 A;  1DIY A;  3GIS X;  1TPG A;  1NT0 A;  1XKA L;  2VVV L;  2P95 L;  2WPJ E;  3TZI A;  1YO8 A;  4FM5 A;  5JBB E;  5L2Y L;  2XBY L;  3LC3 B;  4NG9 L;  1MQ5 L;  3SOB B;  2ADX A;  2BZ6 L;  1JBU L;  2BQ6 A;  4JZD L;  3FFG L;  2OYU P;  3TGF A;  4JZE L;  3HPT A;  2KV4 A;  2BOH A;  3CA7 A;  3N8Z A;  2W26 B;  1FJS L;  1PXX A;  1HT8 A;  2MGR A;  3LIW B;  4OTY A;  2UWL B;  1PTH A;  1UZK A;  5IKR A;  4D90 A;  1I0U A;  2RHP A;  1CEJ A;  2W2N E;  1LPK A;  1FAX L;  4RRY A;  1OB1 C;  2W2M E;  1YUK B;  3HS6 A;  1KIG L;  3V65 B;  4YZU B;  1NFX B;  4PH9 A;  2P93 L;  1WHF A;  2I9A A;  3MQE A;  1COU A;  4D0F A;  1UZP A;  4CUD A;  2Q1J B;  4OTJ A;  3V64 C;  2AYL A;  2XC0 L;  2Y5H L;  2BOU A;  3QMO A;  1W8B L;  1EBV A;  4X8T L;  4RRZ A;  1AUT L;  4XBM A;  1HAF A;  1Z6C A;  3EGF A;  2EI7 B;  2CJI B;  2P94 L;  2VH6 B;  1IQJ L;  1IGZ A;  4BTT A;  2P16 L;  2FD6 A;  4Y7B B;  2XBX L;  1V3X B;  3KQB L;  4TGF A;  4BTU A;  1EQH A;  1LPZ A;  1APO A;  3NTB A;  3KK6 A;  1MOX C;  2F9B L;  3KRK A;  4RRX A;  5L30 L;  1W7X L;  3NJP C;  1PFX L;  1UZQ A;  3N8V A;  1G1S A;  1FSB A;  5IKV A;  1YUG A;  1IJQ A;  1IQE L;  2EI6 B;  3OLT A;  5CKN A;  2K2S B;  1CVU A;  5F1A A;  1FAK L;  1IQN L;  1KLJ L;  4BDW A;  2PHB B;  1G1R A;  1NQL B;  3MDL A;  2OYE P;  2WG3 C;  4JYU L;  2Y7Z B;  4XL1 A;  1CVW L;  3POY A;  1EAI C;  3ASI A;  4Y79 B;  3GCW E;  3N8W A;  1IQK L;  1J9C L;  4NA9 L;  3ZYJ B;  4ZHA B;  2Y82 B;  2XBV L;  1IQH L;  3SOV A;  1L5G B;  1KLI L;  2JKH L;  1CQE A;  3OLU A;  2J94 B;  1XDT R;  1RFN B;  4NGA L;  2EI8 B;  3IJE B;  3SOQ A;  3FCS B;  1HRF A;  1YGC L;  3HS5 A;  1U8C B;  5JBA E;  1LQD A;  4D0E A;  1HX2 A;  5KIR A;  1QFK L;  2UWP B;  1YUF A;  4YT6 L;  3NT1 A;  2Y5G L;  1EZQ B;  5IKT A;  1N7D A;  1UZJ A;  3M36 L;  3KQE L;  4O1Z A;  3N8Y B;  1A3P A;  1P0S L;  3CFW A;  1N1I A;  1EPI A;  5JBC E;  5COX A;  5JVY A;  3KQD L;  5CKM A;  2WPK E;  3QCW A;  2Y7X B;  3U73 A;  4ISI L;  1U67 A;  3BPS E;  3N8X A;  4RRW A;  4X8U L;  1KLO A;  3KL6 B;  1KSN B;  5IKQ A;  2P28 B;  3QH0 A;  1HAE A;  2BQW A;  4A7I A;  3F6U L;  2VWL L;  1HCG B;  1P9J A;  2WPI E;  5K0H B;  3CS7 L;  2I9B A;  2GD4 A;  2W3K B;  3ELA L;  4MMZ B;  2P3F N;  2YGP A;  3H5C B;  2BOK L;  3HO4 A;  1JL9 A;  1URK A;  3R05 A;  2PUQ L;  4BXW A;  2PR3 B;  2Y80 B;  1K37 A;  2VWM K;  1EPJ A;  2Y5F L;  4COX A;  4ISH L;  1DX5 I;  4BTI A;  5JVZ A;  2Y38 A;  2WFT A;  2BQ7 A;  4O02 B;  2XC4 L;  3LN0 A;  3TH3 L;  5L2Z L;  1CX2 A;  1WHE A;  1G1Q A;  1IQI L;  4ZXX L;  3LTG D;  3Q7D A;  2FZZ L;  3P5B L;  2VJ3 A;  1FFM A;  1F0R B;  3IIT B;  6COX A;  1IQG L;  2VVC K;  2W2P E;  1EPG A;  3ZYI B;  1IOX A;  3M37 L;  1CCV A;  1ATE A;  5F19 A;  2TGF A;  1DQB A;  4C16 A;  2J2U B;  1FF7 A;  1IQF L;  4ZH8 B;  3Q3K B;  1C5M F;  1EMN A;  3LTF B;  3PGH A;  1NPE B;  1FE2 A;  2KB9 A;  4E1G A;  4Y7A B;  2NPR A;  2BO2 A;  2W2Q E;  1NFW B;  3NTG A;  5KN5 C;  2BOX A;  2MGP A;  4LMF A;  3BT1 A;  3FBY A;  1F7E A;  3LAQ A;  3F1S B;  1NZI A;  2M74 A;  1HRE A;  1LMJ A;  2KL7 A;  3HS7 A;  2B7D L;  4Y71 B;  1ADX A;  3KQC L;  1BF9 A;  4JYV L;  4G1M B;  1ATB A;  2WPH E;  1IQM L;  2WG4 B;  3TK5 B;  1EGF A;  3LN1 A;  1WU1 B;  2Y81 B;  4Y76 B;  2P26 A;  3TBD A;  1JV2 B; 
#chains in the Genus database with same CATH topology
 4Z0K B;  1ZAQ A;  2WPL E;  1F7M A;  4ZXY L;  2UWO B;  1DDX A;  1NFU B;  2YGQ A;  1PGE A;  2J34 B;  2J38 B;  2D1J B;  2RNL A;  5CIS A;  2RA0 L;  1IGX A;  1G2L B;  3LC5 B;  4AQT A;  4MMY B;  4Z6A L;  1G1T A;  2WYJ B;  3ZYG A;  1IVO C;  2P3T A;  1M1X B;  2FLG A;  1L3Y A;  2MHP A;  1LK9 A;  4RUT A;  5I46 L;  2VWO L;  2XC5 L;  2WYG B;  1HT5 A;  3HO3 A;  4YT7 L;  4GU4 A;  1HJ7 A;  5FDQ A;  3HO5 A;  1XKB A;  2BMG A;  3RR3 A;  1PRH A;  1CCF A;  2WPM E;  5CKQ A;  3C9A C;  4LOR A;  3GCX E;  1EQG A;  3DEM A;  2W3I B;  5JB9 E;  1B9W A;  1GK5 A;  2YGO A;  3N8W B;  1XFE A;  4M10 A;  3N8Y A;  4CSY A;  3CEN L;  1G2M B;  2DDU A;  2WFX B;  2P3U A;  4X8S L;  1SZB A;  4CUF A;  2G00 L;  4X8V L;  1F0S B;  1TLE A;  1V1I A;  5JW1 A;  2VWN L;  4MMX B;  1QIU A;  1ATA A;  4M11 A;  1APQ A;  1NFY B;  2BT8 A;  2P3F L;  2J95 B;  3K9X A;  4BDX A;  2K2T A;  4CUE A;  4JZF L;  1X7A L;  1EMO A;  1ATD A;  1TOZ A;  1HZ8 A;  4BXS A;  5E8D A;  3ENS A;  1EPH A;  1DVA L;  1IOE L;  2FLR L;  1Q4G A;  2W2O E;  2W86 A;  4ZAE B;  3U7U G;  4RS0 A;  4Y6D B;  3KCG L;  3TK6 B;  2HOX A;  1IQL L;  2H9E L;  2XBW L;  2VH0 B;  5EGM B;  1MQ6 L;  1Z6E L;  2VVU L;  1IP0 A;  1O5D L;  1K36 A;  4Z0L A;  1LPG A;  2FLB L;  2J4I B;  5JB8 E;  3BT2 A;  1KKE A;  4XLW A;  3SW2 A;  1DIY A;  3GIS X;  1TPG A;  1NT0 A;  1XKA L;  2VVV L;  2P95 L;  2WPJ E;  2BT7 A;  3TZI A;  1YO8 A;  4FM5 A;  5JBB E;  5L2Y L;  2XBY L;  3LC3 B;  4NG9 L;  1MQ5 L;  3SOB B;  2ADX A;  4A94 C;  2BZ6 L;  1JBU L;  2BQ6 A;  4JZD L;  3FFG L;  2OYU P;  3TGF A;  4JZE L;  3HPT A;  2KV4 A;  2BOH A;  3CA7 A;  3N8Z A;  2W26 B;  1FJS L;  1PXX A;  1HT8 A;  2MGR A;  3LIW B;  1V1H A;  4OTY A;  2UWL B;  1PTH A;  1UZK A;  5IKR A;  4D90 A;  1I0U A;  2RHP A;  1CEJ A;  2W2N E;  1LPK A;  1FAX L;  4RRY A;  1OB1 C;  2W2M E;  1YUK B;  3HS6 A;  1KIG L;  3V65 B;  4YZU B;  1NFX B;  4PH9 A;  2P93 L;  1WHF A;  2I9A A;  3MQE A;  1COU A;  2JJL A;  4D0F A;  1UZP A;  4CUD A;  2WZP P;  2Q1J B;  4OTJ A;  3V64 C;  2AYL A;  2XC0 L;  2Y5H L;  2BOU A;  3QMO A;  1W8B L;  1EBV A;  4X8T L;  4RRZ A;  1AUT L;  4XBM A;  1HAF A;  1Z6C A;  3EGF A;  2EI7 B;  2CJI B;  2P94 L;  2VH6 B;  1IQJ L;  1IGZ A;  4BTT A;  2P16 L;  2FD6 A;  4Y7B B;  2XBX L;  1V3X B;  3KQB L;  4TGF A;  4BTU A;  1EQH A;  1LPZ A;  1APO A;  3KK6 A;  3NTB A;  1MOX C;  2F9B L;  3KRK A;  4RRX A;  5L30 L;  1W7X L;  3NJP C;  1PFX L;  1UZQ A;  3N8V A;  1G1S A;  1FSB A;  5IKV A;  1YUG A;  1IJQ A;  1IQE L;  2EI6 B;  3OLT A;  3S6X A;  5CKN A;  2K2S B;  1CVU A;  5F1A A;  1FAK L;  1IQN L;  1KLJ L;  4BDW A;  2PHB B;  1G1R A;  1NQL B;  3MDL A;  2OYE P;  2WG3 C;  4JYU L;  2Y7Z B;  4XL1 A;  1CVW L;  3POY A;  1EAI C;  3ASI A;  4Y79 B;  3GCW E;  2VRS A;  3N8W A;  1IQK L;  1J9C L;  4NA9 L;  3ZYJ B;  4ZHA B;  2Y82 B;  2XBV L;  1IQH L;  3SOV A;  1L5G B;  1KLI L;  2JKH L;  1CQE A;  3OLU A;  2J94 B;  1XDT R;  1RFN B;  4NGA L;  2EI8 B;  3IJE B;  3SOQ A;  3FCS B;  1HRF A;  1YGC L;  3HS5 A;  1U8C B;  5JBA E;  1LQD A;  4D0E A;  1HX2 A;  5KIR A;  1QFK L;  2UWP B;  1YUF A;  4YT6 L;  3NT1 A;  2Y5G L;  1EZQ B;  5IKT A;  1N7D A;  1UZJ A;  3M36 L;  3KQE L;  4O1Z A;  3N8Y B;  1A3P A;  1P0S L;  3CFW A;  1N1I A;  1EPI A;  5JBC E;  5COX A;  5JVY A;  2HOR A;  4GU3 A;  3KQD L;  5CKM A;  2WPK E;  3QCW A;  2Y7X B;  3U73 A;  4ISI L;  1U67 A;  3BPS E;  3N8X A;  4RRW A;  4X8U L;  1KLO A;  3KL6 B;  1KSN B;  5IKQ A;  2P28 B;  3QH0 A;  1HAE A;  2BQW A;  4A7I A;  3F6U L;  2VWL L;  1HCG B;  1P9J A;  2WPI E;  5K0H B;  3CS7 L;  2I9B A;  2GD4 A;  2W3K B;  3ELA L;  4MMZ B;  2P3F N;  2YGP A;  3H5C B;  2BOK L;  3HO4 A;  1JL9 A;  1URK A;  3R05 A;  2PUQ L;  4BXW A;  2PR3 B;  2Y80 B;  1K37 A;  2VWM K;  1EPJ A;  2Y5F L;  4COX A;  4ISH L;  1DX5 I;  4BTI A;  5JVZ A;  2Y38 A;  2WFT A;  2BQ7 A;  4O02 B;  2XC4 L;  3LN0 A;  3TH3 L;  5L2Z L;  1CX2 A;  1WHE A;  1G1Q A;  1IQI L;  4ZXX L;  3LTG D;  3Q7D A;  2FZZ L;  3P5B L;  2VJ3 A;  1FFM A;  1F0R B;  3IIT B;  6COX A;  1IQG L;  2VVC K;  2W2P E;  1EPG A;  3ZYI B;  1IOX A;  2KNI A;  3M37 L;  1CCV A;  1ATE A;  5F19 A;  2TGF A;  1DQB A;  4C16 A;  2J2U B;  1FF7 A;  1IQF L;  4ZH8 B;  3Q3K B;  1C5M F;  1EMN A;  3LTF B;  3PGH A;  1NPE B;  1FE2 A;  2KB9 A;  4E1G A;  4Y7A B;  2NPR A;  2BO2 A;  2W2Q E;  1NFW B;  3NTG A;  5KN5 C;  2BOX A;  2MGP A;  4LMF A;  1LMM A;  2H9E C;  3BT1 A;  3FBY A;  1F7E A;  3LAQ A;  3F1S B;  1NZI A;  2M74 A;  1HRE A;  1LMJ A;  2KL7 A;  3HS7 A;  2B7D L;  4Y71 B;  1ADX A;  3KQC L;  1BF9 A;  4JYV L;  4G1M B;  1ATB A;  2WPH E;  1IQM L;  2WG4 B;  3TK5 B;  1EGF A;  3LN1 A;  1WU1 B;  2Y81 B;  4Y76 B;  2BSF A;  2P26 A;  3TBD A;  1JV2 B; 
#chains in the Genus database with same CATH homology
 4Z0K B;  1ZAQ A;  2WPL E;  1F7M A;  4ZXY L;  2UWO B;  1DDX A;  1NFU B;  2YGQ A;  1PGE A;  2J34 B;  2J38 B;  2D1J B;  2RNL A;  5CIS A;  2RA0 L;  1IGX A;  1G2L B;  3LC5 B;  4AQT A;  4MMY B;  4Z6A L;  1G1T A;  2WYJ B;  3ZYG A;  1IVO C;  2P3T A;  1M1X B;  2FLG A;  1L3Y A;  2MHP A;  4RUT A;  5I46 L;  2VWO L;  2XC5 L;  2WYG B;  1HT5 A;  3HO3 A;  4YT7 L;  1HJ7 A;  5FDQ A;  3HO5 A;  1XKB A;  2BMG A;  3RR3 A;  1PRH A;  1CCF A;  2WPM E;  5CKQ A;  3C9A C;  4LOR A;  3GCX E;  1EQG A;  3DEM A;  2W3I B;  5JB9 E;  1B9W A;  1GK5 A;  2YGO A;  3N8W B;  1XFE A;  4M10 A;  3N8Y A;  4CSY A;  3CEN L;  1G2M B;  2DDU A;  2WFX B;  2P3U A;  4X8S L;  1SZB A;  4CUF A;  2G00 L;  4X8V L;  1F0S B;  1TLE A;  5JW1 A;  2VWN L;  4MMX B;  1ATA A;  4M11 A;  1APQ A;  1NFY B;  2P3F L;  2J95 B;  3K9X A;  4BDX A;  2K2T A;  4CUE A;  4JZF L;  1X7A L;  1EMO A;  1ATD A;  1TOZ A;  1HZ8 A;  4BXS A;  5E8D A;  3ENS A;  1EPH A;  1DVA L;  1IOE L;  2FLR L;  1Q4G A;  2W2O E;  2W86 A;  4ZAE B;  3U7U G;  4RS0 A;  4Y6D B;  3KCG L;  3TK6 B;  1IQL L;  2H9E L;  2XBW L;  2VH0 B;  5EGM B;  1MQ6 L;  1Z6E L;  2VVU L;  1IP0 A;  1O5D L;  1K36 A;  4Z0L A;  1LPG A;  2FLB L;  2J4I B;  5JB8 E;  3BT2 A;  4XLW A;  3SW2 A;  1DIY A;  3GIS X;  1TPG A;  1NT0 A;  1XKA L;  2VVV L;  2P95 L;  2WPJ E;  3TZI A;  1YO8 A;  4FM5 A;  5JBB E;  5L2Y L;  2XBY L;  3LC3 B;  4NG9 L;  1MQ5 L;  3SOB B;  2ADX A;  4A94 C;  2BZ6 L;  1JBU L;  2BQ6 A;  4JZD L;  3FFG L;  2OYU P;  3TGF A;  4JZE L;  3HPT A;  2KV4 A;  2BOH A;  3CA7 A;  3N8Z A;  2W26 B;  1FJS L;  1PXX A;  1HT8 A;  2MGR A;  3LIW B;  4OTY A;  2UWL B;  1PTH A;  1UZK A;  5IKR A;  4D90 A;  1I0U A;  2RHP A;  1CEJ A;  2W2N E;  1LPK A;  1FAX L;  4RRY A;  1OB1 C;  2W2M E;  1YUK B;  3HS6 A;  1KIG L;  3V65 B;  4YZU B;  1NFX B;  4PH9 A;  2P93 L;  1WHF A;  2I9A A;  3MQE A;  1COU A;  4D0F A;  1UZP A;  4CUD A;  2WZP P;  2Q1J B;  4OTJ A;  3V64 C;  2AYL A;  2XC0 L;  2Y5H L;  2BOU A;  3QMO A;  1W8B L;  1EBV A;  4X8T L;  4RRZ A;  1AUT L;  4XBM A;  1HAF A;  1Z6C A;  3EGF A;  2EI7 B;  2CJI B;  2P94 L;  2VH6 B;  1IQJ L;  1IGZ A;  4BTT A;  2P16 L;  2FD6 A;  4Y7B B;  2XBX L;  1V3X B;  3KQB L;  4TGF A;  4BTU A;  1EQH A;  1LPZ A;  1APO A;  3KK6 A;  3NTB A;  1MOX C;  2F9B L;  3KRK A;  4RRX A;  5L30 L;  1W7X L;  3NJP C;  1PFX L;  1UZQ A;  3N8V A;  1G1S A;  1FSB A;  5IKV A;  1YUG A;  1IJQ A;  1IQE L;  2EI6 B;  3OLT A;  3S6X A;  5CKN A;  2K2S B;  1CVU A;  5F1A A;  1FAK L;  1IQN L;  1KLJ L;  4BDW A;  2PHB B;  1G1R A;  1NQL B;  3MDL A;  2OYE P;  2WG3 C;  4JYU L;  2Y7Z B;  4XL1 A;  1CVW L;  3POY A;  1EAI C;  3ASI A;  4Y79 B;  3GCW E;  3N8W A;  1IQK L;  1J9C L;  4NA9 L;  3ZYJ B;  4ZHA B;  2Y82 B;  2XBV L;  1IQH L;  3SOV A;  1L5G B;  1KLI L;  2JKH L;  1CQE A;  3OLU A;  2J94 B;  1XDT R;  1RFN B;  4NGA L;  2EI8 B;  3IJE B;  3SOQ A;  3FCS B;  1HRF A;  1YGC L;  3HS5 A;  1U8C B;  5JBA E;  1LQD A;  4D0E A;  1HX2 A;  5KIR A;  1QFK L;  2UWP B;  1YUF A;  4YT6 L;  3NT1 A;  2Y5G L;  1EZQ B;  5IKT A;  1N7D A;  1UZJ A;  3M36 L;  3KQE L;  4O1Z A;  3N8Y B;  1A3P A;  1P0S L;  3CFW A;  1N1I A;  1EPI A;  5JBC E;  5COX A;  5JVY A;  3KQD L;  5CKM A;  2WPK E;  3QCW A;  2Y7X B;  3U73 A;  4ISI L;  1U67 A;  3BPS E;  3N8X A;  4RRW A;  4X8U L;  1KLO A;  3KL6 B;  1KSN B;  5IKQ A;  2P28 B;  3QH0 A;  1HAE A;  2BQW A;  4A7I A;  3F6U L;  2VWL L;  1HCG B;  1P9J A;  2WPI E;  5K0H B;  3CS7 L;  2I9B A;  2GD4 A;  2W3K B;  3ELA L;  4MMZ B;  2P3F N;  2YGP A;  3H5C B;  2BOK L;  3HO4 A;  1JL9 A;  1URK A;  3R05 A;  2PUQ L;  4BXW A;  2PR3 B;  2Y80 B;  1K37 A;  2VWM K;  1EPJ A;  2Y5F L;  4COX A;  4ISH L;  1DX5 I;  4BTI A;  5JVZ A;  2Y38 A;  2WFT A;  2BQ7 A;  4O02 B;  2XC4 L;  3LN0 A;  3TH3 L;  5L2Z L;  1CX2 A;  1WHE A;  1G1Q A;  1IQI L;  4ZXX L;  3LTG D;  3Q7D A;  2FZZ L;  3P5B L;  2VJ3 A;  1FFM A;  1F0R B;  3IIT B;  6COX A;  1IQG L;  2VVC K;  2W2P E;  1EPG A;  3ZYI B;  1IOX A;  2KNI A;  3M37 L;  1CCV A;  1ATE A;  5F19 A;  2TGF A;  1DQB A;  4C16 A;  2J2U B;  1FF7 A;  1IQF L;  4ZH8 B;  3Q3K B;  1C5M F;  1EMN A;  3LTF B;  3PGH A;  1NPE B;  1FE2 A;  2KB9 A;  4E1G A;  4Y7A B;  2NPR A;  2BO2 A;  2W2Q E;  1NFW B;  3NTG A;  5KN5 C;  2BOX A;  2MGP A;  4LMF A;  1LMM A;  2H9E C;  3BT1 A;  3FBY A;  1F7E A;  3LAQ A;  3F1S B;  1NZI A;  2M74 A;  1HRE A;  1LMJ A;  2KL7 A;  3HS7 A;  2B7D L;  4Y71 B;  1ADX A;  3KQC L;  1BF9 A;  4JYV L;  4G1M B;  1ATB A;  2WPH E;  1IQM L;  2WG4 B;  3TK5 B;  1EGF A;  3LN1 A;  1WU1 B;  2Y81 B;  4Y76 B;  2P26 A;  3TBD A;  1JV2 B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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