2V5OA

Structure of human igf2r domains 11-14
Total Genus 112
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
112
sequence length
613
structure length
604
Chain Sequence
CQVTNPSTGHLFDLSSLSGRAGFTAAYSEKGLVYMSICGENENCPPGVGACFGQTRISVGKANKRLRYVDQVLQLVYKDGSPCPSKSGLSYKSVISFVCRPEAGPTNRPMLISLDKQTCTLFFSWHTPLACEQATECSVRNGSSIVDLSPLIHRTGGYEAYDESTNPDFYINICQPLNPMHAVPCPAGAAVCKVPIDGPPIDIGRVAGPPILNPIANEIYLNFESSTPCLADNYTSLIAFHCKRGVSMGTPKLLRTSECDFVFEWETPVVCPDEVRMDGCTLTDEQLLYSFNLSSLSTSTFKVTRDSRTYSVGVCTFAVGPEQGGCKDGGVCLLSGTKGASFGRLQSMKLDYRHQDEAVVLSYVNGDRCPPETDDGVPCVFPFIFNGKSYEECIIESRAKLWCSTTADYDRDHEWGFCRHSNSYRTSSIIFKCDEDEDIGRPQVFSEVRGCDVTFEWKTKVVCPPKKLECKFVQKHKTYDLRLLSSLTGSWSLVHNGVSYYINLCQKIYKGPLGCSERASICRRTTTGDVQVLGLVHTQKLGVIGDKVVVTYSKGYPCGGNKTASSVIELTCTKTVGRPAFKRFDIDSCTYYFSWDSRAACAVK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structure and Functional Analysis of the Igf-II/Igf2R Interaction
pubmed doi rcsb
molecule tags Receptor
source organism Homo sapiens
molecule keywords CATION-INDEPENDENT MANNOSE-6-PHOSPHATE RECEPTOR
total genus 112
structure length 604
sequence length 613
ec nomenclature
pdb deposition date 2007-07-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00040 fn2 Fibronectin type II domain
A PF00878 CIMR Cation-independent mannose-6-phosphate receptor repeat
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.10.10 Mainly Beta Ribbon Seminal Fluid Protein PDC-109 (Domain B) Fibronectin, type II, collagen-binding 2v5oA04
2.70.130.10 Mainly Beta Distorted Sandwich Cation-dependent Mannose-6-phosphate Receptor; Chain A Mannose-6-phosphate receptor binding domain 2v5oA01
2.70.130.10 Mainly Beta Distorted Sandwich Cation-dependent Mannose-6-phosphate Receptor; Chain A Mannose-6-phosphate receptor binding domain 2v5oA05
2.70.130.10 Mainly Beta Distorted Sandwich Cation-dependent Mannose-6-phosphate Receptor; Chain A Mannose-6-phosphate receptor binding domain 2v5oA03
2.70.130.10 Mainly Beta Distorted Sandwich Cation-dependent Mannose-6-phosphate Receptor; Chain A Mannose-6-phosphate receptor binding domain 2v5oA02
1H8PA 3K42A 2L21A 1E88A 3AIHA 2V5OA 1M6PA 2N1HA 2L2GA 1Q25A 1GP0A 2M6TA 2FN2A 3MQLA 3CY4A 2L2AA 1KEOA 2CNJD 1GXDA 2KVAA 1E8BA 2LLAA 4XQMA 1GP3A 1L6JA 2V5NA 2M68A 2RL7A 5IEIA 2RL8A 2LVXA 3K43A 1SYOA 1E6FA 1CXWA 1C39A 2KVBA 1J7MA 3K41A 2L29A 1GQBA 1KS0A 2RLBA 1CK7A 1QO6A 3M7PA 1SZ0A 1PDCA 1EAKA 2RL9A
chains in the Genus database with same CATH superfamily
1OGBA 3K42A 1YU1A 3WX7A 3N3FA 3WD0A 2V5OA 4Z2LA 1GP0A 2M6TA 3CY4A 1W1VA 1KEOA 2CNJD 1GXDA 2XD1A 4OJLA 4XQMA 4IJEA 2Y2NA 3K43A 1OGGA 3HONA 4IBDA 2Y2GA 1CXWA 2Y2MA 4TX8A 4OJ6A 3WD2A 4IBBA 3L25A 2Y2LA 1H0GA 1J7MA 4OJ5A 4GH9A 1QO6A 1PDCA 3L26A 3KS4A 1W1PA 4Z2GA 4IBKA 2Y2PA 4HMEA 4OUIA 1Q25A 2FN2A 3L2AA 1GOIA 1E8BA 4LG2A 4IBJA 2Y2IA 2RL8A 4MB3A 4NZ4A 1E6FA 1E6RA 1GPFA 1ED7A 4QNLA 1C39A 4IBGA 4NZ3A 1E6PA 1KS0A 1YUEA 2Y2QA 3WD1A 3AIHA 1M6PA 2N1HA 2L2GA 5BPVA 4Z2IA 2L2AA 3L27A 4Z2HA 4IJFA 1W1YA 3L28A 2KVAA 2LLAA 1L6JA 2JE5A 4Z2KA 4NYUA 5IEIA 1YU2A 1W1TA 4NZ5A 4GHLA 4NYYA 4HMDA 2FFFB 3K41A 1O6IA 1UR9A 2L29A 4IBFA 1GQBA 1CK7A 1UR8A 4Z2JA 4OJOA 3HSHA 4MB4A 2Y2JA 1E15A 1H8PA 1E6ZA 1EAKA 3WD4A 2L21A 2D49A 1H0IA 3L29A 1E88A 4MB5A 4GHAA 2Y2HA 3MQLA 2JCHA 4OJPA 3FKEA 1GP3A 2RTSA 2V5NA 2M68A 2RL7A 4IBCA 2LVXA 4IBEA 1SYOA 1YU0A 4NZ1A 2XD5A 1YU4A 2IOUA 3WD3A 2KVBA 1E6NA 2Y2KA 2UWXA 4HMCA 2Y2OA 4NY2A 1YU3A 2BG1A 2RLBA 3M7PA 3KS8A 1AIWA 4IBIA 1SZ0A 2RL9A
chains in the Genus database with same CATH topology
1H8PA 3K42A 2L21A 1E88A 3AIHA 2V5OA 1M6PA 2N1HA 2L2GA 1Q25A 1GP0A 2M6TA 2FN2A 3MQLA 3CY4A 2L2AA 1KEOA 2CNJD 1GXDA 2KVAA 1E8BA 2LLAA 4XQMA 1GP3A 1L6JA 2V5NA 2M68A 2RL7A 5IEIA 2RL8A 2LVXA 3K43A 1SYOA 1E6FA 1CXWA 1C39A 2KVBA 1J7MA 3K41A 2L29A 1GQBA 1KS0A 2RLBA 1CK7A 1QO6A 3M7PA 1SZ0A 1PDCA 1EAKA 2RL9A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1H8P A;  3K42 A;  2L21 A;  1E88 A;  3AIH A;  2V5O A;  1M6P A;  2N1H A;  2L2G A;  1Q25 A;  1GP0 A;  2M6T A;  2FN2 A;  3MQL A;  3CY4 A;  2L2A A;  1KEO A;  2CNJ D;  1GXD A;  2KVA A;  1E8B A;  2LLA A;  4XQM A;  1GP3 A;  1L6J A;  2V5N A;  2M68 A;  2RL7 A;  5IEI A;  2RL8 A;  2LVX A;  3K43 A;  1SYO A;  1E6F A;  1CXW A;  1C39 A;  2KVB A;  1J7M A;  3K41 A;  2L29 A;  1GQB A;  1KS0 A;  2RLB A;  1CK7 A;  1QO6 A;  3M7P A;  1SZ0 A;  1PDC A;  1EAK A;  2RL9 A; 
#chains in the Genus database with same CATH topology
 1OGB A;  3K42 A;  1YU1 A;  3WX7 A;  3N3F A;  3WD0 A;  2V5O A;  4Z2L A;  1GP0 A;  2M6T A;  3CY4 A;  1W1V A;  1KEO A;  2CNJ D;  1GXD A;  2XD1 A;  4OJL A;  4XQM A;  4IJE A;  2Y2N A;  3K43 A;  1OGG A;  3HON A;  4IBD A;  2Y2G A;  1CXW A;  2Y2M A;  4TX8 A;  4OJ6 A;  3WD2 A;  4IBB A;  3L25 A;  2Y2L A;  1H0G A;  1J7M A;  4OJ5 A;  4GH9 A;  1QO6 A;  1PDC A;  3L26 A;  3KS4 A;  1W1P A;  4Z2G A;  4IBK A;  2Y2P A;  4HME A;  4OUI A;  1Q25 A;  2FN2 A;  3L2A A;  1GOI A;  1E8B A;  4LG2 A;  4IBJ A;  2Y2I A;  2RL8 A;  4MB3 A;  4NZ4 A;  1E6F A;  1E6R A;  1GPF A;  1ED7 A;  4QNL A;  1C39 A;  4IBG A;  4NZ3 A;  1E6P A;  1KS0 A;  1YUE A;  2Y2Q A;  3WD1 A;  3AIH A;  1M6P A;  2N1H A;  2L2G A;  5BPV A;  4Z2I A;  2L2A A;  3L27 A;  4Z2H A;  4IJF A;  1W1Y A;  3L28 A;  2KVA A;  2LLA A;  1L6J A;  2JE5 A;  4Z2K A;  4NYU A;  5IEI A;  1YU2 A;  1W1T A;  4NZ5 A;  4GHL A;  4NYY A;  4HMD A;  2FFF B;  3K41 A;  1O6I A;  1UR9 A;  2L29 A;  4IBF A;  1GQB A;  1CK7 A;  1UR8 A;  4Z2J A;  4OJO A;  3HSH A;  4MB4 A;  2Y2J A;  1E15 A;  1H8P A;  1E6Z A;  1EAK A;  3WD4 A;  2L21 A;  2D49 A;  1H0I A;  3L29 A;  1E88 A;  4MB5 A;  4GHA A;  2Y2H A;  3MQL A;  2JCH A;  4OJP A;  3FKE A;  1GP3 A;  2RTS A;  2V5N A;  2M68 A;  2RL7 A;  4IBC A;  2LVX A;  4IBE A;  1SYO A;  1YU0 A;  4NZ1 A;  2XD5 A;  1YU4 A;  2IOU A;  3WD3 A;  2KVB A;  1E6N A;  2Y2K A;  2UWX A;  4HMC A;  2Y2O A;  4NY2 A;  1YU3 A;  2BG1 A;  2RLB A;  3M7P A;  3KS8 A;  1AIW A;  4IBI A;  1SZ0 A;  2RL9 A; 
#chains in the Genus database with same CATH homology
 1H8P A;  3K42 A;  2L21 A;  1E88 A;  3AIH A;  2V5O A;  1M6P A;  2N1H A;  2L2G A;  1Q25 A;  1GP0 A;  2M6T A;  2FN2 A;  3MQL A;  3CY4 A;  2L2A A;  1KEO A;  2CNJ D;  1GXD A;  2KVA A;  1E8B A;  2LLA A;  4XQM A;  1GP3 A;  1L6J A;  2V5N A;  2M68 A;  2RL7 A;  5IEI A;  2RL8 A;  2LVX A;  3K43 A;  1SYO A;  1E6F A;  1CXW A;  1C39 A;  2KVB A;  1J7M A;  3K41 A;  2L29 A;  1GQB A;  1KS0 A;  2RLB A;  1CK7 A;  1QO6 A;  3M7P A;  1SZ0 A;  1PDC A;  1EAK A;  2RL9 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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