2V5OA

Structure of human igf2r domains 11-14
Total Genus 112
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
112
sequence length
613
structure length
604
Chain Sequence
CQVTNPSTGHLFDLSSLSGRAGFTAAYSEKGLVYMSICGENENCPPGVGACFGQTRISVGKANKRLRYVDQVLQLVYKDGSPCPSKSGLSYKSVISFVCRPEAGPTNRPMLISLDKQTCTLFFSWHTPLACEQATECSVRNGSSIVDLSPLIHRTGGYEAYDESTNPDFYINICQPLNPMHAVPCPAGAAVCKVPIDGPPIDIGRVAGPPILNPIANEIYLNFESSTPCLADNYTSLIAFHCKRGVSMGTPKLLRTSECDFVFEWETPVVCPDEVRMDGCTLTDEQLLYSFNLSSLSTSTFKVTRDSRTYSVGVCTFAVGPEQGGCKDGGVCLLSGTKGASFGRLQSMKLDYRHQDEAVVLSYVNGDRCPPETDDGVPCVFPFIFNGKSYEECIIESRAKLWCSTTADYDRDHEWGFCRHSNSYRTSSIIFKCDEDEDIGRPQVFSEVRGCDVTFEWKTKVVCPPKKLECKFVQKHKTYDLRLLSSLTGSWSLVHNGVSYYINLCQKIYKGPLGCSERASICRRTTTGDVQVLGLVHTQKLGVIGDKVVVTYSKGYPCGGNKTASSVIELTCTKTVGRPAFKRFDIDSCTYYFSWDSRAACAVK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structure and Functional Analysis of the Igf-II/Igf2R Interaction
pubmed doi rcsb
molecule tags Receptor
source organism Homo sapiens
molecule keywords CATION-INDEPENDENT MANNOSE-6-PHOSPHATE RECEPTOR
total genus 112
structure length 604
sequence length 613
ec nomenclature
pdb deposition date 2007-07-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00040 fn2 Fibronectin type II domain
A PF00878 CIMR Cation-independent mannose-6-phosphate receptor repeat
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.10.10 Mainly Beta Ribbon Seminal Fluid Protein PDC-109 (Domain B) Fibronectin, type II, collagen-binding 2v5oA04
2.70.130.10 Mainly Beta Distorted Sandwich Cation-dependent Mannose-6-phosphate Receptor; Chain A Mannose-6-phosphate receptor binding domain 2v5oA01
2.70.130.10 Mainly Beta Distorted Sandwich Cation-dependent Mannose-6-phosphate Receptor; Chain A Mannose-6-phosphate receptor binding domain 2v5oA05
2.70.130.10 Mainly Beta Distorted Sandwich Cation-dependent Mannose-6-phosphate Receptor; Chain A Mannose-6-phosphate receptor binding domain 2v5oA03
2.70.130.10 Mainly Beta Distorted Sandwich Cation-dependent Mannose-6-phosphate Receptor; Chain A Mannose-6-phosphate receptor binding domain 2v5oA02
3K42A 1H8PA 5IEIA 1C39A 3MQLA 2FN2A 1QO6A 2L21A 1GQBA 1SZ0A 3K41A 1KEOA 1GXDA 2RL9A 2M68A 1SYOA 3AIHA 1CK7A 2KVAA 3K43A 2M6TA 4XQMA 2L2AA 1E8BA 1E6FA 2V5OA 1KS0A 1Q25A 2L2GA 1M6PA 2KVBA 2N1HA 2V5NA 1EAKA 3CY4A 2RL8A 1E88A 1PDCA 1L6JA 3M7PA 1J7MA 1GP0A 2LLAA 2L29A 2CNJD 1GP3A 2RL7A 1CXWA 2LVXA 2RLBA
chains in the Genus database with same CATH superfamily
1AIWA 5IEIA 2FN2A 2L21A 1YU0A 1E6ZA 1SZ0A 1KEOA 1UR9A 2Y2QA 1W1YA 2XD5A 3HSHA 2Y2GA 1CK7A 4XQMA 4NYUA 2L2GA 2Y2JA 1M6PA 4Z2LA 4IBJA 4OJ5A 4OJ6A 2Y2NA 4IJEA 1PDCA 1J7MA 4HMCA 4Z2GA 3N3FA 5BPVA 4HMDA 3KS8A 3L28A 3K42A 1H8PA 4Z2HA 1YU1A 4LG2A 3WD2A 3K41A 4IBCA 3WD1A 2JCHA 3AIHA 1E6NA 2L2AA 4NY2A 1Q25A 3HONA 1H0GA 1E15A 4GH9A 2KVBA 4QNLA 2UWXA 4IBEA 2Y2KA 3M7PA 2Y2HA 2CNJD 3L26A 4IBFA 2RL7A 4NZ5A 4NZ3A 1ED7A 2Y2MA 1GPFA 3L2AA 4IJFA 4NZ4A 1OGGA 1W1TA 1GXDA 4IBKA 1SYOA 4TX8A 4MB4A 1W1VA 1E6PA 4OJLA 3L27A 2Y2IA 4MB5A 3L25A 1YUEA 2Y2PA 3KS4A 4OJPA 1UR8A 2IOUA 3L29A 2N1HA 4GHAA 3CY4A 2RL8A 1E88A 3WD4A 1L6JA 1GP0A 4Z2KA 4IBIA 1GP3A 4IBGA 2RTSA 3WD3A 4Z2JA 2LVXA 2RLBA 1C39A 3MQLA 1QO6A 3WX7A 4HMEA 4NZ1A 2FFFB 4IBBA 1GOIA 4MB3A 1GQBA 3FKEA 2Y2OA 2RL9A 2M68A 3WD0A 4IBDA 2KVAA 3K43A 2M6TA 4GHLA 2Y2LA 1E8BA 1O6IA 4NYYA 2D49A 1E6RA 2V5OA 4Z2IA 2BG1A 1KS0A 1E6FA 1OGBA 1W1PA 2V5NA 1EAKA 4OJOA 1YU4A 2LLAA 4OUIA 1YU2A 2JE5A 2L29A 1YU3A 1H0IA 1CXWA 2XD1A
chains in the Genus database with same CATH topology
3K42A 1H8PA 5IEIA 1C39A 3MQLA 2FN2A 1QO6A 2L21A 1GQBA 1SZ0A 3K41A 1KEOA 1GXDA 2RL9A 2M68A 1SYOA 3AIHA 1CK7A 2KVAA 3K43A 2M6TA 4XQMA 2L2AA 1E8BA 1E6FA 2V5OA 1KS0A 1Q25A 2L2GA 1M6PA 2KVBA 2N1HA 2V5NA 1EAKA 3CY4A 2RL8A 1E88A 1PDCA 1L6JA 3M7PA 1J7MA 1GP0A 2LLAA 2L29A 2CNJD 1GP3A 2RL7A 1CXWA 2LVXA 2RLBA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3K42 A;  1H8P A;  5IEI A;  1C39 A;  3MQL A;  2FN2 A;  1QO6 A;  2L21 A;  1GQB A;  1SZ0 A;  3K41 A;  1KEO A;  1GXD A;  2RL9 A;  2M68 A;  1SYO A;  3AIH A;  1CK7 A;  2KVA A;  3K43 A;  2M6T A;  4XQM A;  2L2A A;  1E8B A;  1E6F A;  2V5O A;  1KS0 A;  1Q25 A;  2L2G A;  1M6P A;  2KVB A;  2N1H A;  2V5N A;  1EAK A;  3CY4 A;  2RL8 A;  1E88 A;  1PDC A;  1L6J A;  3M7P A;  1J7M A;  1GP0 A;  2LLA A;  2L29 A;  2CNJ D;  1GP3 A;  2RL7 A;  1CXW A;  2LVX A;  2RLB A; 
#chains in the Genus database with same CATH topology
 1AIW A;  5IEI A;  2FN2 A;  2L21 A;  1YU0 A;  1E6Z A;  1SZ0 A;  1KEO A;  1UR9 A;  2Y2Q A;  1W1Y A;  2XD5 A;  3HSH A;  2Y2G A;  1CK7 A;  4XQM A;  4NYU A;  2L2G A;  2Y2J A;  1M6P A;  4Z2L A;  4IBJ A;  4OJ5 A;  4OJ6 A;  2Y2N A;  4IJE A;  1PDC A;  1J7M A;  4HMC A;  4Z2G A;  3N3F A;  5BPV A;  4HMD A;  3KS8 A;  3L28 A;  3K42 A;  1H8P A;  4Z2H A;  1YU1 A;  4LG2 A;  3WD2 A;  3K41 A;  4IBC A;  3WD1 A;  2JCH A;  3AIH A;  1E6N A;  2L2A A;  4NY2 A;  1Q25 A;  3HON A;  1H0G A;  1E15 A;  4GH9 A;  2KVB A;  4QNL A;  2UWX A;  4IBE A;  2Y2K A;  3M7P A;  2Y2H A;  2CNJ D;  3L26 A;  4IBF A;  2RL7 A;  4NZ5 A;  4NZ3 A;  1ED7 A;  2Y2M A;  1GPF A;  3L2A A;  4IJF A;  4NZ4 A;  1OGG A;  1W1T A;  1GXD A;  4IBK A;  1SYO A;  4TX8 A;  4MB4 A;  1W1V A;  1E6P A;  4OJL A;  3L27 A;  2Y2I A;  4MB5 A;  3L25 A;  1YUE A;  2Y2P A;  3KS4 A;  4OJP A;  1UR8 A;  2IOU A;  3L29 A;  2N1H A;  4GHA A;  3CY4 A;  2RL8 A;  1E88 A;  3WD4 A;  1L6J A;  1GP0 A;  4Z2K A;  4IBI A;  1GP3 A;  4IBG A;  2RTS A;  3WD3 A;  4Z2J A;  2LVX A;  2RLB A;  1C39 A;  3MQL A;  1QO6 A;  3WX7 A;  4HME A;  4NZ1 A;  2FFF B;  4IBB A;  1GOI A;  4MB3 A;  1GQB A;  3FKE A;  2Y2O A;  2RL9 A;  2M68 A;  3WD0 A;  4IBD A;  2KVA A;  3K43 A;  2M6T A;  4GHL A;  2Y2L A;  1E8B A;  1O6I A;  4NYY A;  2D49 A;  1E6R A;  2V5O A;  4Z2I A;  2BG1 A;  1KS0 A;  1E6F A;  1OGB A;  1W1P A;  2V5N A;  1EAK A;  4OJO A;  1YU4 A;  2LLA A;  4OUI A;  1YU2 A;  2JE5 A;  2L29 A;  1YU3 A;  1H0I A;  1CXW A;  2XD1 A; 
#chains in the Genus database with same CATH homology
 3K42 A;  1H8P A;  5IEI A;  1C39 A;  3MQL A;  2FN2 A;  1QO6 A;  2L21 A;  1GQB A;  1SZ0 A;  3K41 A;  1KEO A;  1GXD A;  2RL9 A;  2M68 A;  1SYO A;  3AIH A;  1CK7 A;  2KVA A;  3K43 A;  2M6T A;  4XQM A;  2L2A A;  1E8B A;  1E6F A;  2V5O A;  1KS0 A;  1Q25 A;  2L2G A;  1M6P A;  2KVB A;  2N1H A;  2V5N A;  1EAK A;  3CY4 A;  2RL8 A;  1E88 A;  1PDC A;  1L6J A;  3M7P A;  1J7M A;  1GP0 A;  2LLA A;  2L29 A;  2CNJ D;  1GP3 A;  2RL7 A;  1CXW A;  2LVX A;  2RLB A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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