1H3IA

Crystal structure of the histone methyltransferase set7/9
Total Genus 71
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
71
sequence length
293
structure length
293
Chain Sequence
FFFDGSTLEGYYVDDALQGQGVYTYEDGGVLQGTYVDGELNGPAQEYDTDGRLIFKGQYKDNIRHGVCWIYYPDGGSLVGEVNEDGEMTGEKIAYVYPDERTALYGKFIDGEMIEGKLATLMSTEEGRPHFELMPGNSVYHFDKSTSSCISTNALLPDPYESERVYVAESLISSAGEGLFSKVAVGPNTVMSFYNGVRITHQEVDSRDWALNGNTLSLDEETVIDVPEPYNHVSKYCASLGHKANHSFTPNCIYDMFVHPRFGPIKCIRTLRAVEADEELTVAYGYDHSPPGK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Transferase
molecule keywords HISTONE H3 LYSINE 4 SPECIFIC METHYLTRANSFERASE
publication title Crystal Structure and Functional Analysis of the Histone Methyltransferase Set7/9
pubmed doi rcsb
source organism Homo sapiens
total genus 71
structure length 293
sequence length 293
chains with identical sequence B
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2002-09-04

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF02493 MORN MORN repeat
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.20.110.10 Mainly Beta Single Sheet Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain 1h3iA01
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 1h3iA02
3MEKA 4WUYA 4RZ0A 3RU0A 4BUPA 3RAYA 1O9SA 4O30A 5JJ0A 4MI0A 5KJKA 3OXFA 3KMAA 2JV0A 4O6FA 3M59A 3IHXA 5F5EA 3SWCA 3M5AA 3M58A 5JIYA 3S7DA 4MI5A 3BO5A 5TTFA 3OXGA 4NJ5A 3TG4A 2BQZA 4H12A 3S7BA 5CPRB 5ARGA 5KJNA 3KMTA 2RFIA 5ARFA 3HNAA 3DB5A 4Z4PA 1N3JA 4QEOA 4YNPA 5CCLA 3OPEA 3PDNA 4I51A 4YPAA 5AYFA 3M57A 3VUZA 1N6AA 4C1QA 3QWPA 4E47A 3MO5A 4JLGA 3DALA 3F9ZA 1XQHA 3M54A 2W5ZA 1ML9A 5T0KA 3RQ4A 3CBOA 3VV0A 4IJ8A 4NVQA 4FMUA 3TG5A 2F69A 3MO0A 5HQ8A 5JHNA 1MT6A 4J83A 4AU7A 1MUFA 5T0MA 5KJLA 3RJWA 3M56A 5EG2A 3S7JA 5F6LA 3CBPA 5HI7A 5EX3A 5KJMA 2R3AA 1PEGA 1H3IA 3OOIA 3S8PA 2IGQA 2QPWA 3M53A 5F6KC 3SW9A 2O8JA 5LSZA 4YPUA 3K5KA 4J7FA 3EP0A 3F9XA 1ZKKA 3KMJA 4YPEA 3MO2A 5LSXA 3N71A 3RIBA 3S7FA 1N6CA 4LDGA 5TEGA 4YNDA 3FPDA 5JINA 3F9YA 4IJDA 4QENA 3CBMA 4QEPA 5F59A 3OS5A 3OXLA 1MVXA 2G46A 5T5GA 4YNMA 3QWWA 5EX0A 3M55A 5CCMA 1MVHA 4J7IA 3QWVA 3F9WA 4J8OA 5TH7A 4JDSA 2W5YA
chains in the Genus database with same CATH superfamily
3MEKA 4WUYA 4RZ0A 3RU0A 4BUPA 3RAYA 1O9SA 4O30A 5JJ0A 4MI0A 5KJKA 3OXFA 3KMAA 2JV0A 4O6FA 3M59A 3IHXA 5F5EA 3SWCA 3M5AA 3M58A 5JIYA 3S7DA 4MI5A 3BO5A 5TTFA 3OXGA 4NJ5A 3TG4A 2BQZA 4H12A 3S7BA 5CPRB 5ARGA 5KJNA 3KMTA 2RFIA 5ARFA 3HNAA 3DB5A 4Z4PA 1N3JA 4QEOA 4YNPA 5CCLA 3OPEA 3PDNA 4I51A 4YPAA 5AYFA 3M57A 3VUZA 1N6AA 4C1QA 3QWPA 4E47A 3MO5A 4JLGA 3DALA 3F9ZA 1XQHA 3M54A 2W5ZA 1ML9A 5T0KA 3RQ4A 3CBOA 3VV0A 4IJ8A 4NVQA 4FMUA 3TG5A 2F69A 3MO0A 5HQ8A 5JHNA 1MT6A 4J83A 4AU7A 1MUFA 5T0MA 5KJLA 3RJWA 3M56A 5EG2A 3S7JA 5F6LA 3CBPA 5HI7A 5EX3A 5KJMA 2R3AA 1PEGA 1H3IA 3OOIA 3S8PA 2IGQA 2QPWA 3M53A 5F6KC 3SW9A 2O8JA 5LSZA 4YPUA 3K5KA 4J7FA 3EP0A 3F9XA 1ZKKA 3KMJA 4YPEA 3MO2A 5LSXA 3N71A 3RIBA 3S7FA 1N6CA 4LDGA 5TEGA 4YNDA 3FPDA 5JINA 3F9YA 4IJDA 4QENA 3CBMA 4QEPA 5F59A 3OS5A 3OXLA 1MVXA 2G46A 5T5GA 4YNMA 3QWWA 5EX0A 3M55A 5CCMA 1MVHA 4J7IA 3QWVA 3F9WA 4J8OA 5TH7A 4JDSA 2W5YA
chains in the Genus database with same CATH topology
3MEKA 4WUYA 4RZ0A 3RU0A 4BUPA 3RAYA 1O9SA 4O30A 5JJ0A 4MI0A 5KJKA 3OXFA 3KMAA 2JV0A 4O6FA 3M59A 3IHXA 5F5EA 3SWCA 3M5AA 3M58A 5JIYA 3S7DA 4MI5A 3BO5A 5TTFA 3OXGA 4NJ5A 3TG4A 2BQZA 4H12A 3S7BA 5CPRB 5ARGA 5KJNA 3KMTA 2RFIA 5ARFA 3HNAA 3DB5A 4Z4PA 1N3JA 4QEOA 4YNPA 5CCLA 3OPEA 3PDNA 4I51A 4YPAA 5AYFA 3M57A 3VUZA 1N6AA 4C1QA 3QWPA 4E47A 3MO5A 4JLGA 3DALA 3F9ZA 1XQHA 3M54A 2W5ZA 1ML9A 5T0KA 3RQ4A 3CBOA 3VV0A 4IJ8A 4NVQA 4FMUA 3TG5A 2F69A 3MO0A 5HQ8A 5JHNA 1MT6A 4J83A 4AU7A 1MUFA 5T0MA 5KJLA 3RJWA 3M56A 5EG2A 3S7JA 5F6LA 3CBPA 5HI7A 5EX3A 5KJMA 2R3AA 1PEGA 1H3IA 3OOIA 3S8PA 2IGQA 2QPWA 3M53A 5F6KC 3SW9A 2O8JA 5LSZA 4YPUA 3K5KA 4J7FA 3EP0A 3F9XA 1ZKKA 3KMJA 4YPEA 3MO2A 5LSXA 3N71A 3RIBA 3S7FA 1N6CA 4LDGA 5TEGA 4YNDA 3FPDA 5JINA 3F9YA 4IJDA 4QENA 3CBMA 4QEPA 5F59A 3OS5A 3OXLA 1MVXA 2G46A 5T5GA 4YNMA 3QWWA 5EX0A 3M55A 5CCMA 1MVHA 4J7IA 3QWVA 3F9WA 4J8OA 5TH7A 4JDSA 2W5YA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3MEK A;  4WUY A;  4RZ0 A;  3RU0 A;  4BUP A;  3RAY A;  1O9S A;  4O30 A;  5JJ0 A;  4MI0 A;  5KJK A;  3OXF A;  3KMA A;  2JV0 A;  4O6F A;  3M59 A;  3IHX A;  5F5E A;  3SWC A;  3M5A A;  3M58 A;  5JIY A;  3S7D A;  4MI5 A;  3BO5 A;  5TTF A;  3OXG A;  4NJ5 A;  3TG4 A;  2BQZ A;  4H12 A;  3S7B A;  5CPR B;  5ARG A;  5KJN A;  3KMT A;  2RFI A;  5ARF A;  3HNA A;  3DB5 A;  4Z4P A;  1N3J A;  4QEO A;  4YNP A;  5CCL A;  3OPE A;  3PDN A;  4I51 A;  4YPA A;  5AYF A;  3M57 A;  3VUZ A;  1N6A A;  4C1Q A;  3QWP A;  4E47 A;  3MO5 A;  4JLG A;  3DAL A;  3F9Z A;  1XQH A;  3M54 A;  2W5Z A;  1ML9 A;  5T0K A;  3RQ4 A;  3CBO A;  3VV0 A;  4IJ8 A;  4NVQ A;  4FMU A;  3TG5 A;  2F69 A;  3MO0 A;  5HQ8 A;  5JHN A;  1MT6 A;  4J83 A;  4AU7 A;  1MUF A;  5T0M A;  5KJL A;  3RJW A;  3M56 A;  5EG2 A;  3S7J A;  5F6L A;  3CBP A;  5HI7 A;  5EX3 A;  5KJM A;  2R3A A;  1PEG A;  1H3I A;  3OOI A;  3S8P A;  2IGQ A;  2QPW A;  3M53 A;  5F6K C;  3SW9 A;  2O8J A;  5LSZ A;  4YPU A;  3K5K A;  4J7F A;  3EP0 A;  3F9X A;  1ZKK A;  3KMJ A;  4YPE A;  3MO2 A;  5LSX A;  3N71 A;  3RIB A;  3S7F A;  1N6C A;  4LDG A;  5TEG A;  4YND A;  3FPD A;  5JIN A;  3F9Y A;  4IJD A;  4QEN A;  3CBM A;  4QEP A;  5F59 A;  3OS5 A;  3OXL A;  1MVX A;  2G46 A;  5T5G A;  4YNM A;  3QWW A;  5EX0 A;  3M55 A;  5CCM A;  1MVH A;  4J7I A;  3QWV A;  3F9W A;  4J8O A;  5TH7 A;  4JDS A;  2W5Y A; 
#chains in the Genus database with same CATH topology
 3MEK A;  4WUY A;  4RZ0 A;  3RU0 A;  4BUP A;  3RAY A;  1O9S A;  4O30 A;  5JJ0 A;  4MI0 A;  5KJK A;  3OXF A;  3KMA A;  2JV0 A;  4O6F A;  3M59 A;  3IHX A;  5F5E A;  3SWC A;  3M5A A;  3M58 A;  5JIY A;  3S7D A;  4MI5 A;  3BO5 A;  5TTF A;  3OXG A;  4NJ5 A;  3TG4 A;  2BQZ A;  4H12 A;  3S7B A;  5CPR B;  5ARG A;  5KJN A;  3KMT A;  2RFI A;  5ARF A;  3HNA A;  3DB5 A;  4Z4P A;  1N3J A;  4QEO A;  4YNP A;  5CCL A;  3OPE A;  3PDN A;  4I51 A;  4YPA A;  5AYF A;  3M57 A;  3VUZ A;  1N6A A;  4C1Q A;  3QWP A;  4E47 A;  3MO5 A;  4JLG A;  3DAL A;  3F9Z A;  1XQH A;  3M54 A;  2W5Z A;  1ML9 A;  5T0K A;  3RQ4 A;  3CBO A;  3VV0 A;  4IJ8 A;  4NVQ A;  4FMU A;  3TG5 A;  2F69 A;  3MO0 A;  5HQ8 A;  5JHN A;  1MT6 A;  4J83 A;  4AU7 A;  1MUF A;  5T0M A;  5KJL A;  3RJW A;  3M56 A;  5EG2 A;  3S7J A;  5F6L A;  3CBP A;  5HI7 A;  5EX3 A;  5KJM A;  2R3A A;  1PEG A;  1H3I A;  3OOI A;  3S8P A;  2IGQ A;  2QPW A;  3M53 A;  5F6K C;  3SW9 A;  2O8J A;  5LSZ A;  4YPU A;  3K5K A;  4J7F A;  3EP0 A;  3F9X A;  1ZKK A;  3KMJ A;  4YPE A;  3MO2 A;  5LSX A;  3N71 A;  3RIB A;  3S7F A;  1N6C A;  4LDG A;  5TEG A;  4YND A;  3FPD A;  5JIN A;  3F9Y A;  4IJD A;  4QEN A;  3CBM A;  4QEP A;  5F59 A;  3OS5 A;  3OXL A;  1MVX A;  2G46 A;  5T5G A;  4YNM A;  3QWW A;  5EX0 A;  3M55 A;  5CCM A;  1MVH A;  4J7I A;  3QWV A;  3F9W A;  4J8O A;  5TH7 A;  4JDS A;  2W5Y A; 
#chains in the Genus database with same CATH homology
 3MEK A;  4WUY A;  4RZ0 A;  3RU0 A;  4BUP A;  3RAY A;  1O9S A;  4O30 A;  5JJ0 A;  4MI0 A;  5KJK A;  3OXF A;  3KMA A;  2JV0 A;  4O6F A;  3M59 A;  3IHX A;  5F5E A;  3SWC A;  3M5A A;  3M58 A;  5JIY A;  3S7D A;  4MI5 A;  3BO5 A;  5TTF A;  3OXG A;  4NJ5 A;  3TG4 A;  2BQZ A;  4H12 A;  3S7B A;  5CPR B;  5ARG A;  5KJN A;  3KMT A;  2RFI A;  5ARF A;  3HNA A;  3DB5 A;  4Z4P A;  1N3J A;  4QEO A;  4YNP A;  5CCL A;  3OPE A;  3PDN A;  4I51 A;  4YPA A;  5AYF A;  3M57 A;  3VUZ A;  1N6A A;  4C1Q A;  3QWP A;  4E47 A;  3MO5 A;  4JLG A;  3DAL A;  3F9Z A;  1XQH A;  3M54 A;  2W5Z A;  1ML9 A;  5T0K A;  3RQ4 A;  3CBO A;  3VV0 A;  4IJ8 A;  4NVQ A;  4FMU A;  3TG5 A;  2F69 A;  3MO0 A;  5HQ8 A;  5JHN A;  1MT6 A;  4J83 A;  4AU7 A;  1MUF A;  5T0M A;  5KJL A;  3RJW A;  3M56 A;  5EG2 A;  3S7J A;  5F6L A;  3CBP A;  5HI7 A;  5EX3 A;  5KJM A;  2R3A A;  1PEG A;  1H3I A;  3OOI A;  3S8P A;  2IGQ A;  2QPW A;  3M53 A;  5F6K C;  3SW9 A;  2O8J A;  5LSZ A;  4YPU A;  3K5K A;  4J7F A;  3EP0 A;  3F9X A;  1ZKK A;  3KMJ A;  4YPE A;  3MO2 A;  5LSX A;  3N71 A;  3RIB A;  3S7F A;  1N6C A;  4LDG A;  5TEG A;  4YND A;  3FPD A;  5JIN A;  3F9Y A;  4IJD A;  4QEN A;  3CBM A;  4QEP A;  5F59 A;  3OS5 A;  3OXL A;  1MVX A;  2G46 A;  5T5G A;  4YNM A;  3QWW A;  5EX0 A;  3M55 A;  5CCM A;  1MVH A;  4J7I A;  3QWV A;  3F9W A;  4J8O A;  5TH7 A;  4JDS A;  2W5Y A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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