4NVQA

Human g9a in complex with inhibitor a-366
Total Genus 70
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
70
sequence length
272
structure length
267
Chain Sequence
IRTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSYFTCQCGSEKCKHSAEAIALEQS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Transferase/transferase inhibitor
molecule keywords Histone-lysine N-methyltransferase EHMT2
publication title Discovery and development of potent and selective inhibitors of histone methyltransferase g9a.
pubmed doi rcsb
source organism Homo sapiens
total genus 70
structure length 267
sequence length 272
chains with identical sequence B
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2013-12-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF05033 Pre-SET Pre-SET motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 4nvqA00
4LDGA 5EX0A 4YNDA 3MO2A 3DALA 5JINA 3S7FA 3IHXA 5TH7A 3VV0A 5T5GA 4QEPA 2F69A 4O30A 4YPAA 2QPWA 5F5EA 2W5YA 3S7DA 4NVQA 3QWWA 4YPEA 3OOIA 3FPDA 2JV0A 3PDNA 4QENA 4JLGA 3RQ4A 4FMUA 4BUPA 4J7IA 4YNMA 5HI7A 1O9SA 5ARGA 3OS5A 4J8OA 3RU0A 4JDSA 3M54A 3KMAA 1N3JA 3M57A 4O6FA 4MI5A 3SW9A 5JJ0A 4MI0A 4WUYA 3TG5A 1MVHA 1XQHA 4RZ0A 3QWPA 2RFIA 5AYFA 3S7BA 5JIYA 3RJWA 3F9XA 5F59A 3MO0A 4I51A 5LSXA 3M5AA 3QWVA 1MT6A 5KJNA 5EG2A 3HNAA 3KMJA 5JHNA 4H12A 3M56A 3M53A 1N6CA 3KMTA 2BQZA 5ARFA 3DB5A 5CCLA 5CPRB 2IGQA 2G46A 2R3AA 5T0KA 5EX3A 3CBPA 3OXFA 5KJKA 4YPUA 3S8PA 1PEGA 3K5KA 3CBOA 5TEGA 3VUZA 3RAYA 1ZKKA 3F9ZA 3MEKA 5F6KC 4NJ5A 3CBMA 2O8JA 4AU7A 4J7FA 3OXLA 5F6LA 3BO5A 3MO5A 4IJDA 3EP0A 3M59A 4YNPA 5T0MA 3N71A 5KJLA 5CCMA 3OPEA 3M58A 3TG4A 5TTFA 3OXGA 3RIBA 3S7JA 3SWCA 1MUFA 4Z4PA 1MVXA 1H3IA 4QEOA 5KJMA 1N6AA 4E47A 3F9YA 3M55A 4IJ8A 2W5ZA 1ML9A 4C1QA 5LSZA 3F9WA 4J83A 5HQ8A
chains in the Genus database with same CATH superfamily
4LDGA 5EX0A 4YNDA 3MO2A 3DALA 5JINA 3S7FA 3IHXA 5TH7A 3VV0A 5T5GA 4QEPA 2F69A 4O30A 4YPAA 2QPWA 5F5EA 2W5YA 3S7DA 4NVQA 3QWWA 4YPEA 3OOIA 3FPDA 2JV0A 3PDNA 4QENA 4JLGA 3RQ4A 4FMUA 4BUPA 4J7IA 4YNMA 5HI7A 1O9SA 5ARGA 3OS5A 4J8OA 3RU0A 4JDSA 3M54A 3KMAA 1N3JA 3M57A 4O6FA 4MI5A 3SW9A 5JJ0A 4MI0A 4WUYA 3TG5A 1MVHA 1XQHA 4RZ0A 3QWPA 2RFIA 5AYFA 3S7BA 5JIYA 3RJWA 3F9XA 5F59A 3MO0A 4I51A 5LSXA 3M5AA 3QWVA 1MT6A 5KJNA 5EG2A 3HNAA 3KMJA 5JHNA 4H12A 3M56A 3M53A 1N6CA 3KMTA 2BQZA 5ARFA 3DB5A 5CCLA 5CPRB 2IGQA 2G46A 2R3AA 5T0KA 5EX3A 3CBPA 3OXFA 5KJKA 4YPUA 3S8PA 1PEGA 3K5KA 3CBOA 5TEGA 3VUZA 3RAYA 1ZKKA 3F9ZA 3MEKA 5F6KC 4NJ5A 3CBMA 2O8JA 4AU7A 4J7FA 3OXLA 5F6LA 3BO5A 3MO5A 4IJDA 3EP0A 3M59A 4YNPA 5T0MA 3N71A 5KJLA 5CCMA 3OPEA 3M58A 3TG4A 5TTFA 3OXGA 3RIBA 3S7JA 3SWCA 1MUFA 4Z4PA 1MVXA 1H3IA 4QEOA 5KJMA 1N6AA 4E47A 3F9YA 3M55A 4IJ8A 2W5ZA 1ML9A 4C1QA 5LSZA 3F9WA 4J83A 5HQ8A
chains in the Genus database with same CATH topology
4LDGA 5EX0A 4YNDA 3MO2A 3DALA 5JINA 3S7FA 3IHXA 5TH7A 3VV0A 5T5GA 4QEPA 2F69A 4O30A 4YPAA 2QPWA 5F5EA 2W5YA 3S7DA 4NVQA 3QWWA 4YPEA 3OOIA 3FPDA 2JV0A 3PDNA 4QENA 4JLGA 3RQ4A 4FMUA 4BUPA 4J7IA 4YNMA 5HI7A 1O9SA 5ARGA 3OS5A 4J8OA 3RU0A 4JDSA 3M54A 3KMAA 1N3JA 3M57A 4O6FA 4MI5A 3SW9A 5JJ0A 4MI0A 4WUYA 3TG5A 1MVHA 1XQHA 4RZ0A 3QWPA 2RFIA 5AYFA 3S7BA 5JIYA 3RJWA 3F9XA 5F59A 3MO0A 4I51A 5LSXA 3M5AA 3QWVA 1MT6A 5KJNA 5EG2A 3HNAA 3KMJA 5JHNA 4H12A 3M56A 3M53A 1N6CA 3KMTA 2BQZA 5ARFA 3DB5A 5CCLA 5CPRB 2IGQA 2G46A 2R3AA 5T0KA 5EX3A 3CBPA 3OXFA 5KJKA 4YPUA 3S8PA 1PEGA 3K5KA 3CBOA 5TEGA 3VUZA 3RAYA 1ZKKA 3F9ZA 3MEKA 5F6KC 4NJ5A 3CBMA 2O8JA 4AU7A 4J7FA 3OXLA 5F6LA 3BO5A 3MO5A 4IJDA 3EP0A 3M59A 4YNPA 5T0MA 3N71A 5KJLA 5CCMA 3OPEA 3M58A 3TG4A 5TTFA 3OXGA 3RIBA 3S7JA 3SWCA 1MUFA 4Z4PA 1MVXA 1H3IA 4QEOA 5KJMA 1N6AA 4E47A 3F9YA 3M55A 4IJ8A 2W5ZA 1ML9A 4C1QA 5LSZA 3F9WA 4J83A 5HQ8A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4LDG A;  5EX0 A;  4YND A;  3MO2 A;  3DAL A;  5JIN A;  3S7F A;  3IHX A;  5TH7 A;  3VV0 A;  5T5G A;  4QEP A;  2F69 A;  4O30 A;  4YPA A;  2QPW A;  5F5E A;  2W5Y A;  3S7D A;  4NVQ A;  3QWW A;  4YPE A;  3OOI A;  3FPD A;  2JV0 A;  3PDN A;  4QEN A;  4JLG A;  3RQ4 A;  4FMU A;  4BUP A;  4J7I A;  4YNM A;  5HI7 A;  1O9S A;  5ARG A;  3OS5 A;  4J8O A;  3RU0 A;  4JDS A;  3M54 A;  3KMA A;  1N3J A;  3M57 A;  4O6F A;  4MI5 A;  3SW9 A;  5JJ0 A;  4MI0 A;  4WUY A;  3TG5 A;  1MVH A;  1XQH A;  4RZ0 A;  3QWP A;  2RFI A;  5AYF A;  3S7B A;  5JIY A;  3RJW A;  3F9X A;  5F59 A;  3MO0 A;  4I51 A;  5LSX A;  3M5A A;  3QWV A;  1MT6 A;  5KJN A;  5EG2 A;  3HNA A;  3KMJ A;  5JHN A;  4H12 A;  3M56 A;  3M53 A;  1N6C A;  3KMT A;  2BQZ A;  5ARF A;  3DB5 A;  5CCL A;  5CPR B;  2IGQ A;  2G46 A;  2R3A A;  5T0K A;  5EX3 A;  3CBP A;  3OXF A;  5KJK A;  4YPU A;  3S8P A;  1PEG A;  3K5K A;  3CBO A;  5TEG A;  3VUZ A;  3RAY A;  1ZKK A;  3F9Z A;  3MEK A;  5F6K C;  4NJ5 A;  3CBM A;  2O8J A;  4AU7 A;  4J7F A;  3OXL A;  5F6L A;  3BO5 A;  3MO5 A;  4IJD A;  3EP0 A;  3M59 A;  4YNP A;  5T0M A;  3N71 A;  5KJL A;  5CCM A;  3OPE A;  3M58 A;  3TG4 A;  5TTF A;  3OXG A;  3RIB A;  3S7J A;  3SWC A;  1MUF A;  4Z4P A;  1MVX A;  1H3I A;  4QEO A;  5KJM A;  1N6A A;  4E47 A;  3F9Y A;  3M55 A;  4IJ8 A;  2W5Z A;  1ML9 A;  4C1Q A;  5LSZ A;  3F9W A;  4J83 A;  5HQ8 A; 
#chains in the Genus database with same CATH topology
 4LDG A;  5EX0 A;  4YND A;  3MO2 A;  3DAL A;  5JIN A;  3S7F A;  3IHX A;  5TH7 A;  3VV0 A;  5T5G A;  4QEP A;  2F69 A;  4O30 A;  4YPA A;  2QPW A;  5F5E A;  2W5Y A;  3S7D A;  4NVQ A;  3QWW A;  4YPE A;  3OOI A;  3FPD A;  2JV0 A;  3PDN A;  4QEN A;  4JLG A;  3RQ4 A;  4FMU A;  4BUP A;  4J7I A;  4YNM A;  5HI7 A;  1O9S A;  5ARG A;  3OS5 A;  4J8O A;  3RU0 A;  4JDS A;  3M54 A;  3KMA A;  1N3J A;  3M57 A;  4O6F A;  4MI5 A;  3SW9 A;  5JJ0 A;  4MI0 A;  4WUY A;  3TG5 A;  1MVH A;  1XQH A;  4RZ0 A;  3QWP A;  2RFI A;  5AYF A;  3S7B A;  5JIY A;  3RJW A;  3F9X A;  5F59 A;  3MO0 A;  4I51 A;  5LSX A;  3M5A A;  3QWV A;  1MT6 A;  5KJN A;  5EG2 A;  3HNA A;  3KMJ A;  5JHN A;  4H12 A;  3M56 A;  3M53 A;  1N6C A;  3KMT A;  2BQZ A;  5ARF A;  3DB5 A;  5CCL A;  5CPR B;  2IGQ A;  2G46 A;  2R3A A;  5T0K A;  5EX3 A;  3CBP A;  3OXF A;  5KJK A;  4YPU A;  3S8P A;  1PEG A;  3K5K A;  3CBO A;  5TEG A;  3VUZ A;  3RAY A;  1ZKK A;  3F9Z A;  3MEK A;  5F6K C;  4NJ5 A;  3CBM A;  2O8J A;  4AU7 A;  4J7F A;  3OXL A;  5F6L A;  3BO5 A;  3MO5 A;  4IJD A;  3EP0 A;  3M59 A;  4YNP A;  5T0M A;  3N71 A;  5KJL A;  5CCM A;  3OPE A;  3M58 A;  3TG4 A;  5TTF A;  3OXG A;  3RIB A;  3S7J A;  3SWC A;  1MUF A;  4Z4P A;  1MVX A;  1H3I A;  4QEO A;  5KJM A;  1N6A A;  4E47 A;  3F9Y A;  3M55 A;  4IJ8 A;  2W5Z A;  1ML9 A;  4C1Q A;  5LSZ A;  3F9W A;  4J83 A;  5HQ8 A; 
#chains in the Genus database with same CATH homology
 4LDG A;  5EX0 A;  4YND A;  3MO2 A;  3DAL A;  5JIN A;  3S7F A;  3IHX A;  5TH7 A;  3VV0 A;  5T5G A;  4QEP A;  2F69 A;  4O30 A;  4YPA A;  2QPW A;  5F5E A;  2W5Y A;  3S7D A;  4NVQ A;  3QWW A;  4YPE A;  3OOI A;  3FPD A;  2JV0 A;  3PDN A;  4QEN A;  4JLG A;  3RQ4 A;  4FMU A;  4BUP A;  4J7I A;  4YNM A;  5HI7 A;  1O9S A;  5ARG A;  3OS5 A;  4J8O A;  3RU0 A;  4JDS A;  3M54 A;  3KMA A;  1N3J A;  3M57 A;  4O6F A;  4MI5 A;  3SW9 A;  5JJ0 A;  4MI0 A;  4WUY A;  3TG5 A;  1MVH A;  1XQH A;  4RZ0 A;  3QWP A;  2RFI A;  5AYF A;  3S7B A;  5JIY A;  3RJW A;  3F9X A;  5F59 A;  3MO0 A;  4I51 A;  5LSX A;  3M5A A;  3QWV A;  1MT6 A;  5KJN A;  5EG2 A;  3HNA A;  3KMJ A;  5JHN A;  4H12 A;  3M56 A;  3M53 A;  1N6C A;  3KMT A;  2BQZ A;  5ARF A;  3DB5 A;  5CCL A;  5CPR B;  2IGQ A;  2G46 A;  2R3A A;  5T0K A;  5EX3 A;  3CBP A;  3OXF A;  5KJK A;  4YPU A;  3S8P A;  1PEG A;  3K5K A;  3CBO A;  5TEG A;  3VUZ A;  3RAY A;  1ZKK A;  3F9Z A;  3MEK A;  5F6K C;  4NJ5 A;  3CBM A;  2O8J A;  4AU7 A;  4J7F A;  3OXL A;  5F6L A;  3BO5 A;  3MO5 A;  4IJD A;  3EP0 A;  3M59 A;  4YNP A;  5T0M A;  3N71 A;  5KJL A;  5CCM A;  3OPE A;  3M58 A;  3TG4 A;  5TTF A;  3OXG A;  3RIB A;  3S7J A;  3SWC A;  1MUF A;  4Z4P A;  1MVX A;  1H3I A;  4QEO A;  5KJM A;  1N6A A;  4E47 A;  3F9Y A;  3M55 A;  4IJ8 A;  2W5Z A;  1ML9 A;  4C1Q A;  5LSZ A;  3F9W A;  4J83 A;  5HQ8 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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