4NVQA

Human g9a in complex with inhibitor a-366
Total Genus 70
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
70
sequence length
272
structure length
267
Chain Sequence
b'IRTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSYFTCQCGSEKCKHSAEAIALEQS'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Histone-lysine N-methyltransferase EHMT2
publication title Discovery and development of potent and selective inhibitors of histone methyltransferase g9a.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Transferase/transferase inhibitor
total genus 70
structure length 267
sequence length 272
chains with identical sequence B
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2013-12-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF05033 Pre-SET Pre-SET motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 4nvqA00
3S7DA 3DALA 3M5AA 3F9XA 3IHXA 3OPEA 4NJ5A 3S7FA 5KJMA 3FPDA 4YPAA 3KMTA 3F9WA 3OS5A 5HQ8A 1PEGA 4NVQA 1H3IA 3M57A 5ARGA 5EG2A 3SW9A 3RJWA 3MO5A 3RU0A 5JINA 3HNAA 5CCLA 2R3AA 5CCMA 3CBMA 3M59A 1MVXA 1XQHA 4MI0A 1MUFA 3K5KA 4FMUA 1ML9A 3MO2A 5KJNA 3S7BA 5F5EA 1MVHA 3SWCA 4JDSA 1O9SA 2RFIA 5ARFA 4I51A 4LDGA 3PDNA 4O6FA 3M58A 2JV0A 3BO5A 2W5ZA 4QEOA 4J83A 4E47A 5LSXA 4J7FA 4BUPA 3RAYA 3CBPA 3S7JA 4YPUA 4QEPA 5KJKA 5F6KC 5AYFA 2BQZA 4J8OA 4C1QA 5JJ0A 1MT6A 5T0KA 2IGQA 2QPWA 3EP0A 5EX0A 2W5YA 3TG5A 1N6AA 3QWPA 5CPRB 3VV0A 4J7IA 5HI7A 5JHNA 3OOIA 5LSZA 3KMAA 4MI5A 3F9ZA 1ZKKA 4YNMA 3DB5A 3QWVA 5TEGA 2G46A 5TH7A 3M56A 3M55A 3M54A 1N3JA 3MO0A 5T5GA 3N71A 3M53A 5F6LA 3VUZA 4H12A 4YNDA 3KMJA 1N6CA 4Z4PA 4QENA 5TTFA 4IJ8A 4AU7A 5T0MA 3TG4A 3OXLA 3OXFA 4YNPA 5F59A 5KJLA 4YPEA 3RQ4A 4WUYA 3RIBA 4JLGA 3OXGA 2F69A 5EX3A 3QWWA 3S8PA 4O30A 5JIYA 3MEKA 4IJDA 3F9YA 2O8JA 4RZ0A 3CBOA
chains in the Genus database with same CATH superfamily
3S7DA 3DALA 3M5AA 3F9XA 3IHXA 3OPEA 4NJ5A 3S7FA 5KJMA 3FPDA 4YPAA 3KMTA 3F9WA 3OS5A 5HQ8A 1PEGA 4NVQA 1H3IA 3M57A 5ARGA 5EG2A 3SW9A 3RJWA 3MO5A 3RU0A 5JINA 3HNAA 5CCLA 2R3AA 5CCMA 3CBMA 3M59A 1MVXA 1XQHA 4MI0A 1MUFA 3K5KA 4FMUA 1ML9A 3MO2A 5KJNA 3S7BA 5F5EA 1MVHA 3SWCA 4JDSA 1O9SA 2RFIA 5ARFA 4I51A 4LDGA 3PDNA 4O6FA 3M58A 2JV0A 3BO5A 2W5ZA 4QEOA 4J83A 4E47A 5LSXA 4J7FA 4BUPA 3RAYA 3CBPA 3S7JA 4YPUA 4QEPA 5KJKA 5F6KC 5AYFA 2BQZA 4J8OA 4C1QA 5JJ0A 1MT6A 5T0KA 2IGQA 2QPWA 3EP0A 5EX0A 2W5YA 3TG5A 1N6AA 3QWPA 5CPRB 3VV0A 4J7IA 5HI7A 5JHNA 3OOIA 5LSZA 3KMAA 4MI5A 3F9ZA 1ZKKA 4YNMA 3DB5A 3QWVA 5TEGA 2G46A 5TH7A 3M56A 3M55A 3M54A 1N3JA 3MO0A 5T5GA 3N71A 3M53A 5F6LA 3VUZA 4H12A 4YNDA 3KMJA 1N6CA 4Z4PA 4QENA 5TTFA 4IJ8A 4AU7A 5T0MA 3TG4A 3OXLA 3OXFA 4YNPA 5F59A 5KJLA 4YPEA 3RQ4A 4WUYA 3RIBA 4JLGA 3OXGA 2F69A 5EX3A 3QWWA 3S8PA 4O30A 5JIYA 3MEKA 4IJDA 3F9YA 2O8JA 4RZ0A 3CBOA
chains in the Genus database with same CATH topology
3S7DA 3DALA 3M5AA 3F9XA 3IHXA 3OPEA 4NJ5A 3S7FA 5KJMA 3FPDA 4YPAA 3KMTA 3F9WA 3OS5A 5HQ8A 1PEGA 4NVQA 1H3IA 3M57A 5ARGA 5EG2A 3SW9A 3RJWA 3MO5A 3RU0A 5JINA 3HNAA 5CCLA 2R3AA 5CCMA 3CBMA 3M59A 1MVXA 1XQHA 4MI0A 1MUFA 3K5KA 4FMUA 1ML9A 3MO2A 5KJNA 3S7BA 5F5EA 1MVHA 3SWCA 4JDSA 1O9SA 2RFIA 5ARFA 4I51A 4LDGA 3PDNA 4O6FA 3M58A 2JV0A 3BO5A 2W5ZA 4QEOA 4J83A 4E47A 5LSXA 4J7FA 4BUPA 3RAYA 3CBPA 3S7JA 4YPUA 4QEPA 5KJKA 5F6KC 5AYFA 2BQZA 4J8OA 4C1QA 5JJ0A 1MT6A 5T0KA 2IGQA 2QPWA 3EP0A 5EX0A 2W5YA 3TG5A 1N6AA 3QWPA 5CPRB 3VV0A 4J7IA 5HI7A 5JHNA 3OOIA 5LSZA 3KMAA 4MI5A 3F9ZA 1ZKKA 4YNMA 3DB5A 3QWVA 5TEGA 2G46A 5TH7A 3M56A 3M55A 3M54A 1N3JA 3MO0A 5T5GA 3N71A 3M53A 5F6LA 3VUZA 4H12A 4YNDA 3KMJA 1N6CA 4Z4PA 4QENA 5TTFA 4IJ8A 4AU7A 5T0MA 3TG4A 3OXLA 3OXFA 4YNPA 5F59A 5KJLA 4YPEA 3RQ4A 4WUYA 3RIBA 4JLGA 3OXGA 2F69A 5EX3A 3QWWA 3S8PA 4O30A 5JIYA 3MEKA 4IJDA 3F9YA 2O8JA 4RZ0A 3CBOA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3S7D A;  3DAL A;  3M5A A;  3F9X A;  3IHX A;  3OPE A;  4NJ5 A;  3S7F A;  5KJM A;  3FPD A;  4YPA A;  3KMT A;  3F9W A;  3OS5 A;  5HQ8 A;  1PEG A;  4NVQ A;  1H3I A;  3M57 A;  5ARG A;  5EG2 A;  3SW9 A;  3RJW A;  3MO5 A;  3RU0 A;  5JIN A;  3HNA A;  5CCL A;  2R3A A;  5CCM A;  3CBM A;  3M59 A;  1MVX A;  1XQH A;  4MI0 A;  1MUF A;  3K5K A;  4FMU A;  1ML9 A;  3MO2 A;  5KJN A;  3S7B A;  5F5E A;  1MVH A;  3SWC A;  4JDS A;  1O9S A;  2RFI A;  5ARF A;  4I51 A;  4LDG A;  3PDN A;  4O6F A;  3M58 A;  2JV0 A;  3BO5 A;  2W5Z A;  4QEO A;  4J83 A;  4E47 A;  5LSX A;  4J7F A;  4BUP A;  3RAY A;  3CBP A;  3S7J A;  4YPU A;  4QEP A;  5KJK A;  5F6K C;  5AYF A;  2BQZ A;  4J8O A;  4C1Q A;  5JJ0 A;  1MT6 A;  5T0K A;  2IGQ A;  2QPW A;  3EP0 A;  5EX0 A;  2W5Y A;  3TG5 A;  1N6A A;  3QWP A;  5CPR B;  3VV0 A;  4J7I A;  5HI7 A;  5JHN A;  3OOI A;  5LSZ A;  3KMA A;  4MI5 A;  3F9Z A;  1ZKK A;  4YNM A;  3DB5 A;  3QWV A;  5TEG A;  2G46 A;  5TH7 A;  3M56 A;  3M55 A;  3M54 A;  1N3J A;  3MO0 A;  5T5G A;  3N71 A;  3M53 A;  5F6L A;  3VUZ A;  4H12 A;  4YND A;  3KMJ A;  1N6C A;  4Z4P A;  4QEN A;  5TTF A;  4IJ8 A;  4AU7 A;  5T0M A;  3TG4 A;  3OXL A;  3OXF A;  4YNP A;  5F59 A;  5KJL A;  4YPE A;  3RQ4 A;  4WUY A;  3RIB A;  4JLG A;  3OXG A;  2F69 A;  5EX3 A;  3QWW A;  3S8P A;  4O30 A;  5JIY A;  3MEK A;  4IJD A;  3F9Y A;  2O8J A;  4RZ0 A;  3CBO A; 
#chains in the Genus database with same CATH topology
 3S7D A;  3DAL A;  3M5A A;  3F9X A;  3IHX A;  3OPE A;  4NJ5 A;  3S7F A;  5KJM A;  3FPD A;  4YPA A;  3KMT A;  3F9W A;  3OS5 A;  5HQ8 A;  1PEG A;  4NVQ A;  1H3I A;  3M57 A;  5ARG A;  5EG2 A;  3SW9 A;  3RJW A;  3MO5 A;  3RU0 A;  5JIN A;  3HNA A;  5CCL A;  2R3A A;  5CCM A;  3CBM A;  3M59 A;  1MVX A;  1XQH A;  4MI0 A;  1MUF A;  3K5K A;  4FMU A;  1ML9 A;  3MO2 A;  5KJN A;  3S7B A;  5F5E A;  1MVH A;  3SWC A;  4JDS A;  1O9S A;  2RFI A;  5ARF A;  4I51 A;  4LDG A;  3PDN A;  4O6F A;  3M58 A;  2JV0 A;  3BO5 A;  2W5Z A;  4QEO A;  4J83 A;  4E47 A;  5LSX A;  4J7F A;  4BUP A;  3RAY A;  3CBP A;  3S7J A;  4YPU A;  4QEP A;  5KJK A;  5F6K C;  5AYF A;  2BQZ A;  4J8O A;  4C1Q A;  5JJ0 A;  1MT6 A;  5T0K A;  2IGQ A;  2QPW A;  3EP0 A;  5EX0 A;  2W5Y A;  3TG5 A;  1N6A A;  3QWP A;  5CPR B;  3VV0 A;  4J7I A;  5HI7 A;  5JHN A;  3OOI A;  5LSZ A;  3KMA A;  4MI5 A;  3F9Z A;  1ZKK A;  4YNM A;  3DB5 A;  3QWV A;  5TEG A;  2G46 A;  5TH7 A;  3M56 A;  3M55 A;  3M54 A;  1N3J A;  3MO0 A;  5T5G A;  3N71 A;  3M53 A;  5F6L A;  3VUZ A;  4H12 A;  4YND A;  3KMJ A;  1N6C A;  4Z4P A;  4QEN A;  5TTF A;  4IJ8 A;  4AU7 A;  5T0M A;  3TG4 A;  3OXL A;  3OXF A;  4YNP A;  5F59 A;  5KJL A;  4YPE A;  3RQ4 A;  4WUY A;  3RIB A;  4JLG A;  3OXG A;  2F69 A;  5EX3 A;  3QWW A;  3S8P A;  4O30 A;  5JIY A;  3MEK A;  4IJD A;  3F9Y A;  2O8J A;  4RZ0 A;  3CBO A; 
#chains in the Genus database with same CATH homology
 3S7D A;  3DAL A;  3M5A A;  3F9X A;  3IHX A;  3OPE A;  4NJ5 A;  3S7F A;  5KJM A;  3FPD A;  4YPA A;  3KMT A;  3F9W A;  3OS5 A;  5HQ8 A;  1PEG A;  4NVQ A;  1H3I A;  3M57 A;  5ARG A;  5EG2 A;  3SW9 A;  3RJW A;  3MO5 A;  3RU0 A;  5JIN A;  3HNA A;  5CCL A;  2R3A A;  5CCM A;  3CBM A;  3M59 A;  1MVX A;  1XQH A;  4MI0 A;  1MUF A;  3K5K A;  4FMU A;  1ML9 A;  3MO2 A;  5KJN A;  3S7B A;  5F5E A;  1MVH A;  3SWC A;  4JDS A;  1O9S A;  2RFI A;  5ARF A;  4I51 A;  4LDG A;  3PDN A;  4O6F A;  3M58 A;  2JV0 A;  3BO5 A;  2W5Z A;  4QEO A;  4J83 A;  4E47 A;  5LSX A;  4J7F A;  4BUP A;  3RAY A;  3CBP A;  3S7J A;  4YPU A;  4QEP A;  5KJK A;  5F6K C;  5AYF A;  2BQZ A;  4J8O A;  4C1Q A;  5JJ0 A;  1MT6 A;  5T0K A;  2IGQ A;  2QPW A;  3EP0 A;  5EX0 A;  2W5Y A;  3TG5 A;  1N6A A;  3QWP A;  5CPR B;  3VV0 A;  4J7I A;  5HI7 A;  5JHN A;  3OOI A;  5LSZ A;  3KMA A;  4MI5 A;  3F9Z A;  1ZKK A;  4YNM A;  3DB5 A;  3QWV A;  5TEG A;  2G46 A;  5TH7 A;  3M56 A;  3M55 A;  3M54 A;  1N3J A;  3MO0 A;  5T5G A;  3N71 A;  3M53 A;  5F6L A;  3VUZ A;  4H12 A;  4YND A;  3KMJ A;  1N6C A;  4Z4P A;  4QEN A;  5TTF A;  4IJ8 A;  4AU7 A;  5T0M A;  3TG4 A;  3OXL A;  3OXF A;  4YNP A;  5F59 A;  5KJL A;  4YPE A;  3RQ4 A;  4WUY A;  3RIB A;  4JLG A;  3OXG A;  2F69 A;  5EX3 A;  3QWW A;  3S8P A;  4O30 A;  5JIY A;  3MEK A;  4IJD A;  3F9Y A;  2O8J A;  4RZ0 A;  3CBO A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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