4NVQA

Human g9a in complex with inhibitor a-366
Total Genus 70
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
70
sequence length
272
structure length
267
Chain Sequence
IRTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSYFTCQCGSEKCKHSAEAIALEQS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Discovery and development of potent and selective inhibitors of histone methyltransferase g9a.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Transferase/transferase inhibitor
molecule keywords Histone-lysine N-methyltransferase EHMT2
total genus 70
structure length 267
sequence length 272
chains with identical sequence B
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2013-12-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF05033 Pre-SET Pre-SET motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 4nvqA00
4C1QA 3K5KA 4J7FA 1PEGA 3M55A 5EG2A 5T0KA 3MO0A 3FPDA 5CCLA 3S7FA 4YPEA 1ZKKA 3M57A 4E47A 5F6KC 5KJNA 3F9XA 2F69A 3F9WA 5JINA 5JHNA 2IGQA 4MI5A 4IJ8A 3S7JA 5HI7A 4NVQA 3S7DA 5JJ0A 4YNPA 4LDGA 3VV0A 3M53A 2RFIA 3KMJA 4MI0A 3QWPA 1MVXA 3QWWA 4O6FA 3KMAA 1N6CA 1N3JA 3TG4A 3F9ZA 3OOIA 1MT6A 2G46A 3CBPA 3OPEA 3M59A 3OS5A 5T5GA 4J8OA 5CCMA 3DALA 5EX0A 1XQHA 5LSXA 4FMUA 3SW9A 2BQZA 2W5ZA 5KJMA 3RJWA 3F9YA 4JDSA 5HQ8A 3OXGA 3QWVA 3OXFA 4RZ0A 4YPAA 5KJLA 5F59A 5TH7A 5KJKA 5F5EA 4IJDA 4YNDA 5TEGA 3M54A 3MO5A 5EX3A 3HNAA 3CBOA 3IHXA 3CBMA 3M58A 4Z4PA 3VUZA 3RAYA 2R3AA 5LSZA 1H3IA 4O30A 3RQ4A 1MVHA 4YPUA 3BO5A 4QENA 5JIYA 2JV0A 2O8JA 1MUFA 4H12A 4QEOA 3OXLA 3EP0A 3RU0A 4BUPA 5ARFA 2W5YA 4QEPA 5ARGA 3SWCA 5TTFA 4WUYA 3S8PA 3DB5A 4JLGA 5AYFA 3M5AA 3M56A 2QPWA 4NJ5A 4I51A 3S7BA 3TG5A 3RIBA 4J83A 5CPRB 4J7IA 3PDNA 3MEKA 3N71A 3KMTA 4AU7A 1ML9A 4YNMA 1N6AA 5T0MA 1O9SA 5F6LA 3MO2A
chains in the Genus database with same CATH superfamily
4C1QA 3K5KA 4J7FA 1PEGA 3M55A 5EG2A 5T0KA 3MO0A 3FPDA 5CCLA 3S7FA 4YPEA 1ZKKA 3M57A 4E47A 5F6KC 5KJNA 3F9XA 2F69A 3F9WA 5JINA 5JHNA 2IGQA 4MI5A 4IJ8A 3S7JA 5HI7A 4NVQA 3S7DA 5JJ0A 4YNPA 4LDGA 3VV0A 3M53A 2RFIA 3KMJA 4MI0A 3QWPA 1MVXA 3QWWA 4O6FA 3KMAA 1N6CA 1N3JA 3TG4A 3F9ZA 3OOIA 1MT6A 2G46A 3CBPA 3OPEA 3M59A 3OS5A 5T5GA 4J8OA 5CCMA 3DALA 5EX0A 1XQHA 5LSXA 4FMUA 3SW9A 2BQZA 2W5ZA 5KJMA 3RJWA 3F9YA 4JDSA 5HQ8A 3OXGA 3QWVA 3OXFA 4RZ0A 4YPAA 5KJLA 5F59A 5TH7A 5KJKA 5F5EA 4IJDA 4YNDA 5TEGA 3M54A 3MO5A 5EX3A 3HNAA 3CBOA 3IHXA 3CBMA 3M58A 4Z4PA 3VUZA 3RAYA 2R3AA 5LSZA 1H3IA 4O30A 3RQ4A 1MVHA 4YPUA 3BO5A 4QENA 5JIYA 2JV0A 2O8JA 1MUFA 4H12A 4QEOA 3OXLA 3EP0A 3RU0A 4BUPA 5ARFA 2W5YA 4QEPA 5ARGA 3SWCA 5TTFA 4WUYA 3S8PA 3DB5A 4JLGA 5AYFA 3M5AA 3M56A 2QPWA 4NJ5A 4I51A 3S7BA 3TG5A 3RIBA 4J83A 5CPRB 4J7IA 3PDNA 3MEKA 3N71A 3KMTA 4AU7A 1ML9A 4YNMA 1N6AA 5T0MA 1O9SA 5F6LA 3MO2A
chains in the Genus database with same CATH topology
4C1QA 3K5KA 4J7FA 1PEGA 3M55A 5EG2A 5T0KA 3MO0A 3FPDA 5CCLA 3S7FA 4YPEA 1ZKKA 3M57A 4E47A 5F6KC 5KJNA 3F9XA 2F69A 3F9WA 5JINA 5JHNA 2IGQA 4MI5A 4IJ8A 3S7JA 5HI7A 4NVQA 3S7DA 5JJ0A 4YNPA 4LDGA 3VV0A 3M53A 2RFIA 3KMJA 4MI0A 3QWPA 1MVXA 3QWWA 4O6FA 3KMAA 1N6CA 1N3JA 3TG4A 3F9ZA 3OOIA 1MT6A 2G46A 3CBPA 3OPEA 3M59A 3OS5A 5T5GA 4J8OA 5CCMA 3DALA 5EX0A 1XQHA 5LSXA 4FMUA 3SW9A 2BQZA 2W5ZA 5KJMA 3RJWA 3F9YA 4JDSA 5HQ8A 3OXGA 3QWVA 3OXFA 4RZ0A 4YPAA 5KJLA 5F59A 5TH7A 5KJKA 5F5EA 4IJDA 4YNDA 5TEGA 3M54A 3MO5A 5EX3A 3HNAA 3CBOA 3IHXA 3CBMA 3M58A 4Z4PA 3VUZA 3RAYA 2R3AA 5LSZA 1H3IA 4O30A 3RQ4A 1MVHA 4YPUA 3BO5A 4QENA 5JIYA 2JV0A 2O8JA 1MUFA 4H12A 4QEOA 3OXLA 3EP0A 3RU0A 4BUPA 5ARFA 2W5YA 4QEPA 5ARGA 3SWCA 5TTFA 4WUYA 3S8PA 3DB5A 4JLGA 5AYFA 3M5AA 3M56A 2QPWA 4NJ5A 4I51A 3S7BA 3TG5A 3RIBA 4J83A 5CPRB 4J7IA 3PDNA 3MEKA 3N71A 3KMTA 4AU7A 1ML9A 4YNMA 1N6AA 5T0MA 1O9SA 5F6LA 3MO2A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4C1Q A;  3K5K A;  4J7F A;  1PEG A;  3M55 A;  5EG2 A;  5T0K A;  3MO0 A;  3FPD A;  5CCL A;  3S7F A;  4YPE A;  1ZKK A;  3M57 A;  4E47 A;  5F6K C;  5KJN A;  3F9X A;  2F69 A;  3F9W A;  5JIN A;  5JHN A;  2IGQ A;  4MI5 A;  4IJ8 A;  3S7J A;  5HI7 A;  4NVQ A;  3S7D A;  5JJ0 A;  4YNP A;  4LDG A;  3VV0 A;  3M53 A;  2RFI A;  3KMJ A;  4MI0 A;  3QWP A;  1MVX A;  3QWW A;  4O6F A;  3KMA A;  1N6C A;  1N3J A;  3TG4 A;  3F9Z A;  3OOI A;  1MT6 A;  2G46 A;  3CBP A;  3OPE A;  3M59 A;  3OS5 A;  5T5G A;  4J8O A;  5CCM A;  3DAL A;  5EX0 A;  1XQH A;  5LSX A;  4FMU A;  3SW9 A;  2BQZ A;  2W5Z A;  5KJM A;  3RJW A;  3F9Y A;  4JDS A;  5HQ8 A;  3OXG A;  3QWV A;  3OXF A;  4RZ0 A;  4YPA A;  5KJL A;  5F59 A;  5TH7 A;  5KJK A;  5F5E A;  4IJD A;  4YND A;  5TEG A;  3M54 A;  3MO5 A;  5EX3 A;  3HNA A;  3CBO A;  3IHX A;  3CBM A;  3M58 A;  4Z4P A;  3VUZ A;  3RAY A;  2R3A A;  5LSZ A;  1H3I A;  4O30 A;  3RQ4 A;  1MVH A;  4YPU A;  3BO5 A;  4QEN A;  5JIY A;  2JV0 A;  2O8J A;  1MUF A;  4H12 A;  4QEO A;  3OXL A;  3EP0 A;  3RU0 A;  4BUP A;  5ARF A;  2W5Y A;  4QEP A;  5ARG A;  3SWC A;  5TTF A;  4WUY A;  3S8P A;  3DB5 A;  4JLG A;  5AYF A;  3M5A A;  3M56 A;  2QPW A;  4NJ5 A;  4I51 A;  3S7B A;  3TG5 A;  3RIB A;  4J83 A;  5CPR B;  4J7I A;  3PDN A;  3MEK A;  3N71 A;  3KMT A;  4AU7 A;  1ML9 A;  4YNM A;  1N6A A;  5T0M A;  1O9S A;  5F6L A;  3MO2 A; 
#chains in the Genus database with same CATH topology
 4C1Q A;  3K5K A;  4J7F A;  1PEG A;  3M55 A;  5EG2 A;  5T0K A;  3MO0 A;  3FPD A;  5CCL A;  3S7F A;  4YPE A;  1ZKK A;  3M57 A;  4E47 A;  5F6K C;  5KJN A;  3F9X A;  2F69 A;  3F9W A;  5JIN A;  5JHN A;  2IGQ A;  4MI5 A;  4IJ8 A;  3S7J A;  5HI7 A;  4NVQ A;  3S7D A;  5JJ0 A;  4YNP A;  4LDG A;  3VV0 A;  3M53 A;  2RFI A;  3KMJ A;  4MI0 A;  3QWP A;  1MVX A;  3QWW A;  4O6F A;  3KMA A;  1N6C A;  1N3J A;  3TG4 A;  3F9Z A;  3OOI A;  1MT6 A;  2G46 A;  3CBP A;  3OPE A;  3M59 A;  3OS5 A;  5T5G A;  4J8O A;  5CCM A;  3DAL A;  5EX0 A;  1XQH A;  5LSX A;  4FMU A;  3SW9 A;  2BQZ A;  2W5Z A;  5KJM A;  3RJW A;  3F9Y A;  4JDS A;  5HQ8 A;  3OXG A;  3QWV A;  3OXF A;  4RZ0 A;  4YPA A;  5KJL A;  5F59 A;  5TH7 A;  5KJK A;  5F5E A;  4IJD A;  4YND A;  5TEG A;  3M54 A;  3MO5 A;  5EX3 A;  3HNA A;  3CBO A;  3IHX A;  3CBM A;  3M58 A;  4Z4P A;  3VUZ A;  3RAY A;  2R3A A;  5LSZ A;  1H3I A;  4O30 A;  3RQ4 A;  1MVH A;  4YPU A;  3BO5 A;  4QEN A;  5JIY A;  2JV0 A;  2O8J A;  1MUF A;  4H12 A;  4QEO A;  3OXL A;  3EP0 A;  3RU0 A;  4BUP A;  5ARF A;  2W5Y A;  4QEP A;  5ARG A;  3SWC A;  5TTF A;  4WUY A;  3S8P A;  3DB5 A;  4JLG A;  5AYF A;  3M5A A;  3M56 A;  2QPW A;  4NJ5 A;  4I51 A;  3S7B A;  3TG5 A;  3RIB A;  4J83 A;  5CPR B;  4J7I A;  3PDN A;  3MEK A;  3N71 A;  3KMT A;  4AU7 A;  1ML9 A;  4YNM A;  1N6A A;  5T0M A;  1O9S A;  5F6L A;  3MO2 A; 
#chains in the Genus database with same CATH homology
 4C1Q A;  3K5K A;  4J7F A;  1PEG A;  3M55 A;  5EG2 A;  5T0K A;  3MO0 A;  3FPD A;  5CCL A;  3S7F A;  4YPE A;  1ZKK A;  3M57 A;  4E47 A;  5F6K C;  5KJN A;  3F9X A;  2F69 A;  3F9W A;  5JIN A;  5JHN A;  2IGQ A;  4MI5 A;  4IJ8 A;  3S7J A;  5HI7 A;  4NVQ A;  3S7D A;  5JJ0 A;  4YNP A;  4LDG A;  3VV0 A;  3M53 A;  2RFI A;  3KMJ A;  4MI0 A;  3QWP A;  1MVX A;  3QWW A;  4O6F A;  3KMA A;  1N6C A;  1N3J A;  3TG4 A;  3F9Z A;  3OOI A;  1MT6 A;  2G46 A;  3CBP A;  3OPE A;  3M59 A;  3OS5 A;  5T5G A;  4J8O A;  5CCM A;  3DAL A;  5EX0 A;  1XQH A;  5LSX A;  4FMU A;  3SW9 A;  2BQZ A;  2W5Z A;  5KJM A;  3RJW A;  3F9Y A;  4JDS A;  5HQ8 A;  3OXG A;  3QWV A;  3OXF A;  4RZ0 A;  4YPA A;  5KJL A;  5F59 A;  5TH7 A;  5KJK A;  5F5E A;  4IJD A;  4YND A;  5TEG A;  3M54 A;  3MO5 A;  5EX3 A;  3HNA A;  3CBO A;  3IHX A;  3CBM A;  3M58 A;  4Z4P A;  3VUZ A;  3RAY A;  2R3A A;  5LSZ A;  1H3I A;  4O30 A;  3RQ4 A;  1MVH A;  4YPU A;  3BO5 A;  4QEN A;  5JIY A;  2JV0 A;  2O8J A;  1MUF A;  4H12 A;  4QEO A;  3OXL A;  3EP0 A;  3RU0 A;  4BUP A;  5ARF A;  2W5Y A;  4QEP A;  5ARG A;  3SWC A;  5TTF A;  4WUY A;  3S8P A;  3DB5 A;  4JLG A;  5AYF A;  3M5A A;  3M56 A;  2QPW A;  4NJ5 A;  4I51 A;  3S7B A;  3TG5 A;  3RIB A;  4J83 A;  5CPR B;  4J7I A;  3PDN A;  3MEK A;  3N71 A;  3KMT A;  4AU7 A;  1ML9 A;  4YNM A;  1N6A A;  5T0M A;  1O9S A;  5F6L A;  3MO2 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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