4NVQA

Human g9a in complex with inhibitor a-366
Total Genus 70
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
70
sequence length
272
structure length
267
Chain Sequence
IRTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSYFTCQCGSEKCKHSAEAIALEQS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Histone-lysine N-methyltransferase EHMT2
publication title Discovery and development of potent and selective inhibitors of histone methyltransferase g9a.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Transferase/transferase inhibitor
total genus 70
structure length 267
sequence length 272
chains with identical sequence B
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2013-12-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF05033 Pre-SET Pre-SET motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 4nvqA00
5JHNA 3VV0A 4MI5A 3M57A 2O8JA 5T0MA 3SWCA 5JIYA 3QWVA 5HI7A 5AYFA 3KMAA 5F5EA 1XQHA 1MT6A 5F6LA 1ML9A 4IJDA 4J7IA 1MUFA 2BQZA 4NVQA 5CPRB 4QEOA 2W5ZA 5JINA 1MVXA 5F6KC 3MEKA 2R3AA 4YNDA 3OPEA 5KJKA 2QPWA 1N6AA 4Z4PA 3S7JA 3S7DA 5LSXA 3M58A 1PEGA 4YNPA 3S8PA 3MO0A 4MI0A 1O9SA 1ZKKA 4J8OA 3QWPA 4C1QA 3CBMA 5EX3A 3EP0A 2G46A 5CCLA 5ARGA 4YPEA 3RIBA 2IGQA 2F69A 3DB5A 3TG4A 5JJ0A 3F9XA 3OOIA 4YNMA 5CCMA 3OXFA 4FMUA 3RQ4A 4IJ8A 4I51A 3SW9A 2JV0A 3HNAA 3OS5A 5KJLA 3BO5A 3F9WA 4J7FA 4WUYA 1N3JA 4YPAA 5TEGA 4O6FA 3OXGA 5F59A 4H12A 4O30A 3F9ZA 3RAYA 3FPDA 5TTFA 2RFIA 3CBOA 4YPUA 3KMJA 2W5YA 3M53A 4AU7A 3IHXA 5LSZA 3M54A 3M5AA 3M59A 3DALA 5KJNA 3N71A 3PDNA 3RJWA 5EG2A 4NJ5A 5TH7A 4QENA 3KMTA 5T5GA 4BUPA 3CBPA 3MO2A 1MVHA 1N6CA 4J83A 5T0KA 3M55A 3TG5A 3RU0A 3S7FA 4QEPA 3QWWA 5HQ8A 3OXLA 3K5KA 3F9YA 4JLGA 4LDGA 1H3IA 5EX0A 3VUZA 5KJMA 3M56A 5ARFA 4JDSA 3S7BA 4E47A 3MO5A 4RZ0A
chains in the Genus database with same CATH superfamily
5JHNA 3VV0A 4MI5A 3M57A 2O8JA 5T0MA 3SWCA 5JIYA 3QWVA 5HI7A 5AYFA 3KMAA 5F5EA 1XQHA 1MT6A 5F6LA 1ML9A 4IJDA 4J7IA 1MUFA 2BQZA 4NVQA 5CPRB 4QEOA 2W5ZA 5JINA 1MVXA 5F6KC 3MEKA 2R3AA 4YNDA 3OPEA 5KJKA 2QPWA 1N6AA 4Z4PA 3S7JA 3S7DA 5LSXA 3M58A 1PEGA 4YNPA 3S8PA 3MO0A 4MI0A 1O9SA 1ZKKA 4J8OA 3QWPA 4C1QA 3CBMA 5EX3A 3EP0A 2G46A 5CCLA 5ARGA 4YPEA 3RIBA 2IGQA 2F69A 3DB5A 3TG4A 5JJ0A 3F9XA 3OOIA 4YNMA 5CCMA 3OXFA 4FMUA 3RQ4A 4IJ8A 4I51A 3SW9A 2JV0A 3HNAA 3OS5A 5KJLA 3BO5A 3F9WA 4J7FA 4WUYA 1N3JA 4YPAA 5TEGA 4O6FA 3OXGA 5F59A 4H12A 4O30A 3F9ZA 3RAYA 3FPDA 5TTFA 2RFIA 3CBOA 4YPUA 3KMJA 2W5YA 3M53A 4AU7A 3IHXA 5LSZA 3M54A 3M5AA 3M59A 3DALA 5KJNA 3N71A 3PDNA 3RJWA 5EG2A 4NJ5A 5TH7A 4QENA 3KMTA 5T5GA 4BUPA 3CBPA 3MO2A 1MVHA 1N6CA 4J83A 5T0KA 3M55A 3TG5A 3RU0A 3S7FA 4QEPA 3QWWA 5HQ8A 3OXLA 3K5KA 3F9YA 4JLGA 4LDGA 1H3IA 5EX0A 3VUZA 5KJMA 3M56A 5ARFA 4JDSA 3S7BA 4E47A 3MO5A 4RZ0A
chains in the Genus database with same CATH topology
5JHNA 3VV0A 4MI5A 3M57A 2O8JA 5T0MA 3SWCA 5JIYA 3QWVA 5HI7A 5AYFA 3KMAA 5F5EA 1XQHA 1MT6A 5F6LA 1ML9A 4IJDA 4J7IA 1MUFA 2BQZA 4NVQA 5CPRB 4QEOA 2W5ZA 5JINA 1MVXA 5F6KC 3MEKA 2R3AA 4YNDA 3OPEA 5KJKA 2QPWA 1N6AA 4Z4PA 3S7JA 3S7DA 5LSXA 3M58A 1PEGA 4YNPA 3S8PA 3MO0A 4MI0A 1O9SA 1ZKKA 4J8OA 3QWPA 4C1QA 3CBMA 5EX3A 3EP0A 2G46A 5CCLA 5ARGA 4YPEA 3RIBA 2IGQA 2F69A 3DB5A 3TG4A 5JJ0A 3F9XA 3OOIA 4YNMA 5CCMA 3OXFA 4FMUA 3RQ4A 4IJ8A 4I51A 3SW9A 2JV0A 3HNAA 3OS5A 5KJLA 3BO5A 3F9WA 4J7FA 4WUYA 1N3JA 4YPAA 5TEGA 4O6FA 3OXGA 5F59A 4H12A 4O30A 3F9ZA 3RAYA 3FPDA 5TTFA 2RFIA 3CBOA 4YPUA 3KMJA 2W5YA 3M53A 4AU7A 3IHXA 5LSZA 3M54A 3M5AA 3M59A 3DALA 5KJNA 3N71A 3PDNA 3RJWA 5EG2A 4NJ5A 5TH7A 4QENA 3KMTA 5T5GA 4BUPA 3CBPA 3MO2A 1MVHA 1N6CA 4J83A 5T0KA 3M55A 3TG5A 3RU0A 3S7FA 4QEPA 3QWWA 5HQ8A 3OXLA 3K5KA 3F9YA 4JLGA 4LDGA 1H3IA 5EX0A 3VUZA 5KJMA 3M56A 5ARFA 4JDSA 3S7BA 4E47A 3MO5A 4RZ0A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5JHN A;  3VV0 A;  4MI5 A;  3M57 A;  2O8J A;  5T0M A;  3SWC A;  5JIY A;  3QWV A;  5HI7 A;  5AYF A;  3KMA A;  5F5E A;  1XQH A;  1MT6 A;  5F6L A;  1ML9 A;  4IJD A;  4J7I A;  1MUF A;  2BQZ A;  4NVQ A;  5CPR B;  4QEO A;  2W5Z A;  5JIN A;  1MVX A;  5F6K C;  3MEK A;  2R3A A;  4YND A;  3OPE A;  5KJK A;  2QPW A;  1N6A A;  4Z4P A;  3S7J A;  3S7D A;  5LSX A;  3M58 A;  1PEG A;  4YNP A;  3S8P A;  3MO0 A;  4MI0 A;  1O9S A;  1ZKK A;  4J8O A;  3QWP A;  4C1Q A;  3CBM A;  5EX3 A;  3EP0 A;  2G46 A;  5CCL A;  5ARG A;  4YPE A;  3RIB A;  2IGQ A;  2F69 A;  3DB5 A;  3TG4 A;  5JJ0 A;  3F9X A;  3OOI A;  4YNM A;  5CCM A;  3OXF A;  4FMU A;  3RQ4 A;  4IJ8 A;  4I51 A;  3SW9 A;  2JV0 A;  3HNA A;  3OS5 A;  5KJL A;  3BO5 A;  3F9W A;  4J7F A;  4WUY A;  1N3J A;  4YPA A;  5TEG A;  4O6F A;  3OXG A;  5F59 A;  4H12 A;  4O30 A;  3F9Z A;  3RAY A;  3FPD A;  5TTF A;  2RFI A;  3CBO A;  4YPU A;  3KMJ A;  2W5Y A;  3M53 A;  4AU7 A;  3IHX A;  5LSZ A;  3M54 A;  3M5A A;  3M59 A;  3DAL A;  5KJN A;  3N71 A;  3PDN A;  3RJW A;  5EG2 A;  4NJ5 A;  5TH7 A;  4QEN A;  3KMT A;  5T5G A;  4BUP A;  3CBP A;  3MO2 A;  1MVH A;  1N6C A;  4J83 A;  5T0K A;  3M55 A;  3TG5 A;  3RU0 A;  3S7F A;  4QEP A;  3QWW A;  5HQ8 A;  3OXL A;  3K5K A;  3F9Y A;  4JLG A;  4LDG A;  1H3I A;  5EX0 A;  3VUZ A;  5KJM A;  3M56 A;  5ARF A;  4JDS A;  3S7B A;  4E47 A;  3MO5 A;  4RZ0 A; 
#chains in the Genus database with same CATH topology
 5JHN A;  3VV0 A;  4MI5 A;  3M57 A;  2O8J A;  5T0M A;  3SWC A;  5JIY A;  3QWV A;  5HI7 A;  5AYF A;  3KMA A;  5F5E A;  1XQH A;  1MT6 A;  5F6L A;  1ML9 A;  4IJD A;  4J7I A;  1MUF A;  2BQZ A;  4NVQ A;  5CPR B;  4QEO A;  2W5Z A;  5JIN A;  1MVX A;  5F6K C;  3MEK A;  2R3A A;  4YND A;  3OPE A;  5KJK A;  2QPW A;  1N6A A;  4Z4P A;  3S7J A;  3S7D A;  5LSX A;  3M58 A;  1PEG A;  4YNP A;  3S8P A;  3MO0 A;  4MI0 A;  1O9S A;  1ZKK A;  4J8O A;  3QWP A;  4C1Q A;  3CBM A;  5EX3 A;  3EP0 A;  2G46 A;  5CCL A;  5ARG A;  4YPE A;  3RIB A;  2IGQ A;  2F69 A;  3DB5 A;  3TG4 A;  5JJ0 A;  3F9X A;  3OOI A;  4YNM A;  5CCM A;  3OXF A;  4FMU A;  3RQ4 A;  4IJ8 A;  4I51 A;  3SW9 A;  2JV0 A;  3HNA A;  3OS5 A;  5KJL A;  3BO5 A;  3F9W A;  4J7F A;  4WUY A;  1N3J A;  4YPA A;  5TEG A;  4O6F A;  3OXG A;  5F59 A;  4H12 A;  4O30 A;  3F9Z A;  3RAY A;  3FPD A;  5TTF A;  2RFI A;  3CBO A;  4YPU A;  3KMJ A;  2W5Y A;  3M53 A;  4AU7 A;  3IHX A;  5LSZ A;  3M54 A;  3M5A A;  3M59 A;  3DAL A;  5KJN A;  3N71 A;  3PDN A;  3RJW A;  5EG2 A;  4NJ5 A;  5TH7 A;  4QEN A;  3KMT A;  5T5G A;  4BUP A;  3CBP A;  3MO2 A;  1MVH A;  1N6C A;  4J83 A;  5T0K A;  3M55 A;  3TG5 A;  3RU0 A;  3S7F A;  4QEP A;  3QWW A;  5HQ8 A;  3OXL A;  3K5K A;  3F9Y A;  4JLG A;  4LDG A;  1H3I A;  5EX0 A;  3VUZ A;  5KJM A;  3M56 A;  5ARF A;  4JDS A;  3S7B A;  4E47 A;  3MO5 A;  4RZ0 A; 
#chains in the Genus database with same CATH homology
 5JHN A;  3VV0 A;  4MI5 A;  3M57 A;  2O8J A;  5T0M A;  3SWC A;  5JIY A;  3QWV A;  5HI7 A;  5AYF A;  3KMA A;  5F5E A;  1XQH A;  1MT6 A;  5F6L A;  1ML9 A;  4IJD A;  4J7I A;  1MUF A;  2BQZ A;  4NVQ A;  5CPR B;  4QEO A;  2W5Z A;  5JIN A;  1MVX A;  5F6K C;  3MEK A;  2R3A A;  4YND A;  3OPE A;  5KJK A;  2QPW A;  1N6A A;  4Z4P A;  3S7J A;  3S7D A;  5LSX A;  3M58 A;  1PEG A;  4YNP A;  3S8P A;  3MO0 A;  4MI0 A;  1O9S A;  1ZKK A;  4J8O A;  3QWP A;  4C1Q A;  3CBM A;  5EX3 A;  3EP0 A;  2G46 A;  5CCL A;  5ARG A;  4YPE A;  3RIB A;  2IGQ A;  2F69 A;  3DB5 A;  3TG4 A;  5JJ0 A;  3F9X A;  3OOI A;  4YNM A;  5CCM A;  3OXF A;  4FMU A;  3RQ4 A;  4IJ8 A;  4I51 A;  3SW9 A;  2JV0 A;  3HNA A;  3OS5 A;  5KJL A;  3BO5 A;  3F9W A;  4J7F A;  4WUY A;  1N3J A;  4YPA A;  5TEG A;  4O6F A;  3OXG A;  5F59 A;  4H12 A;  4O30 A;  3F9Z A;  3RAY A;  3FPD A;  5TTF A;  2RFI A;  3CBO A;  4YPU A;  3KMJ A;  2W5Y A;  3M53 A;  4AU7 A;  3IHX A;  5LSZ A;  3M54 A;  3M5A A;  3M59 A;  3DAL A;  5KJN A;  3N71 A;  3PDN A;  3RJW A;  5EG2 A;  4NJ5 A;  5TH7 A;  4QEN A;  3KMT A;  5T5G A;  4BUP A;  3CBP A;  3MO2 A;  1MVH A;  1N6C A;  4J83 A;  5T0K A;  3M55 A;  3TG5 A;  3RU0 A;  3S7F A;  4QEP A;  3QWW A;  5HQ8 A;  3OXL A;  3K5K A;  3F9Y A;  4JLG A;  4LDG A;  1H3I A;  5EX0 A;  3VUZ A;  5KJM A;  3M56 A;  5ARF A;  4JDS A;  3S7B A;  4E47 A;  3MO5 A;  4RZ0 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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