4NVQA

Human g9a in complex with inhibitor a-366
Total Genus 70
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
70
sequence length
272
structure length
267
Chain Sequence
IRTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSYFTCQCGSEKCKHSAEAIALEQS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Histone-lysine N-methyltransferase EHMT2
publication title Discovery and development of potent and selective inhibitors of histone methyltransferase g9a.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Transferase/transferase inhibitor
total genus 70
structure length 267
sequence length 272
chains with identical sequence B
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2013-12-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF05033 Pre-SET Pre-SET motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 4nvqA00
3N71A 5T0KA 2JV0A 5JIYA 2RFIA 2W5ZA 3KMTA 4NVQA 4YNDA 4J7FA 5ARGA 3HNAA 4O30A 5CCLA 3PDNA 5AYFA 5KJMA 3OOIA 4NJ5A 3CBPA 4AU7A 3S8PA 5F5EA 4MI5A 1ML9A 2F69A 3OPEA 4JLGA 3OXLA 4YPUA 4JDSA 3RAYA 3S7JA 4I51A 5LSXA 3M55A 5ARFA 5T0MA 5EX3A 1N3JA 5TH7A 5T5GA 5EG2A 4MI0A 3SW9A 3VUZA 5F6LA 3S7DA 3OS5A 3EP0A 4IJ8A 4J7IA 3IHXA 3QWVA 3TG4A 3DALA 3TG5A 2IGQA 4BUPA 2O8JA 3S7BA 3DB5A 3M57A 3RJWA 3F9ZA 3OXFA 4LDGA 5F6KC 4YNMA 3M54A 4YNPA 1H3IA 3KMJA 1PEGA 3BO5A 3M59A 3QWPA 3M5AA 4J8OA 5F59A 4YPEA 3MO0A 3VV0A 1ZKKA 3MO2A 5TTFA 4QENA 4YPAA 3M58A 2R3AA 4RZ0A 3RIBA 3FPDA 3RU0A 1MVHA 5LSZA 4Z4PA 3SWCA 1N6CA 5CCMA 5KJKA 1MVXA 2G46A 4O6FA 3OXGA 4FMUA 5HQ8A 5JHNA 4WUYA 3MEKA 3M56A 5KJLA 3MO5A 3CBOA 5TEGA 2W5YA 3K5KA 1O9SA 5JJ0A 5JINA 4E47A 3F9YA 4J83A 4H12A 2QPWA 1MUFA 1MT6A 4IJDA 4QEPA 3RQ4A 3F9XA 3F9WA 3KMAA 2BQZA 4C1QA 3S7FA 5HI7A 1XQHA 5CPRB 4QEOA 3M53A 5KJNA 1N6AA 3QWWA 3CBMA 5EX0A
chains in the Genus database with same CATH superfamily
3N71A 5T0KA 2JV0A 5JIYA 2RFIA 2W5ZA 3KMTA 4NVQA 4YNDA 4J7FA 5ARGA 3HNAA 4O30A 5CCLA 3PDNA 5AYFA 5KJMA 3OOIA 4NJ5A 3CBPA 4AU7A 3S8PA 5F5EA 4MI5A 1ML9A 2F69A 3OPEA 4JLGA 3OXLA 4YPUA 4JDSA 3RAYA 3S7JA 4I51A 5LSXA 3M55A 5ARFA 5T0MA 5EX3A 1N3JA 5TH7A 5T5GA 5EG2A 4MI0A 3SW9A 3VUZA 5F6LA 3S7DA 3OS5A 3EP0A 4IJ8A 4J7IA 3IHXA 3QWVA 3TG4A 3DALA 3TG5A 2IGQA 4BUPA 2O8JA 3S7BA 3DB5A 3M57A 3RJWA 3F9ZA 3OXFA 4LDGA 5F6KC 4YNMA 3M54A 4YNPA 1H3IA 3KMJA 1PEGA 3BO5A 3M59A 3QWPA 3M5AA 4J8OA 5F59A 4YPEA 3MO0A 3VV0A 1ZKKA 3MO2A 5TTFA 4QENA 4YPAA 3M58A 2R3AA 4RZ0A 3RIBA 3FPDA 3RU0A 1MVHA 5LSZA 4Z4PA 3SWCA 1N6CA 5CCMA 5KJKA 1MVXA 2G46A 4O6FA 3OXGA 4FMUA 5HQ8A 5JHNA 4WUYA 3MEKA 3M56A 5KJLA 3MO5A 3CBOA 5TEGA 2W5YA 3K5KA 1O9SA 5JJ0A 5JINA 4E47A 3F9YA 4J83A 4H12A 2QPWA 1MUFA 1MT6A 4IJDA 4QEPA 3RQ4A 3F9XA 3F9WA 3KMAA 2BQZA 4C1QA 3S7FA 5HI7A 1XQHA 5CPRB 4QEOA 3M53A 5KJNA 1N6AA 3QWWA 3CBMA 5EX0A
chains in the Genus database with same CATH topology
3N71A 5T0KA 2JV0A 5JIYA 2RFIA 2W5ZA 3KMTA 4NVQA 4YNDA 4J7FA 5ARGA 3HNAA 4O30A 5CCLA 3PDNA 5AYFA 5KJMA 3OOIA 4NJ5A 3CBPA 4AU7A 3S8PA 5F5EA 4MI5A 1ML9A 2F69A 3OPEA 4JLGA 3OXLA 4YPUA 4JDSA 3RAYA 3S7JA 4I51A 5LSXA 3M55A 5ARFA 5T0MA 5EX3A 1N3JA 5TH7A 5T5GA 5EG2A 4MI0A 3SW9A 3VUZA 5F6LA 3S7DA 3OS5A 3EP0A 4IJ8A 4J7IA 3IHXA 3QWVA 3TG4A 3DALA 3TG5A 2IGQA 4BUPA 2O8JA 3S7BA 3DB5A 3M57A 3RJWA 3F9ZA 3OXFA 4LDGA 5F6KC 4YNMA 3M54A 4YNPA 1H3IA 3KMJA 1PEGA 3BO5A 3M59A 3QWPA 3M5AA 4J8OA 5F59A 4YPEA 3MO0A 3VV0A 1ZKKA 3MO2A 5TTFA 4QENA 4YPAA 3M58A 2R3AA 4RZ0A 3RIBA 3FPDA 3RU0A 1MVHA 5LSZA 4Z4PA 3SWCA 1N6CA 5CCMA 5KJKA 1MVXA 2G46A 4O6FA 3OXGA 4FMUA 5HQ8A 5JHNA 4WUYA 3MEKA 3M56A 5KJLA 3MO5A 3CBOA 5TEGA 2W5YA 3K5KA 1O9SA 5JJ0A 5JINA 4E47A 3F9YA 4J83A 4H12A 2QPWA 1MUFA 1MT6A 4IJDA 4QEPA 3RQ4A 3F9XA 3F9WA 3KMAA 2BQZA 4C1QA 3S7FA 5HI7A 1XQHA 5CPRB 4QEOA 3M53A 5KJNA 1N6AA 3QWWA 3CBMA 5EX0A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3N71 A;  5T0K A;  2JV0 A;  5JIY A;  2RFI A;  2W5Z A;  3KMT A;  4NVQ A;  4YND A;  4J7F A;  5ARG A;  3HNA A;  4O30 A;  5CCL A;  3PDN A;  5AYF A;  5KJM A;  3OOI A;  4NJ5 A;  3CBP A;  4AU7 A;  3S8P A;  5F5E A;  4MI5 A;  1ML9 A;  2F69 A;  3OPE A;  4JLG A;  3OXL A;  4YPU A;  4JDS A;  3RAY A;  3S7J A;  4I51 A;  5LSX A;  3M55 A;  5ARF A;  5T0M A;  5EX3 A;  1N3J A;  5TH7 A;  5T5G A;  5EG2 A;  4MI0 A;  3SW9 A;  3VUZ A;  5F6L A;  3S7D A;  3OS5 A;  3EP0 A;  4IJ8 A;  4J7I A;  3IHX A;  3QWV A;  3TG4 A;  3DAL A;  3TG5 A;  2IGQ A;  4BUP A;  2O8J A;  3S7B A;  3DB5 A;  3M57 A;  3RJW A;  3F9Z A;  3OXF A;  4LDG A;  5F6K C;  4YNM A;  3M54 A;  4YNP A;  1H3I A;  3KMJ A;  1PEG A;  3BO5 A;  3M59 A;  3QWP A;  3M5A A;  4J8O A;  5F59 A;  4YPE A;  3MO0 A;  3VV0 A;  1ZKK A;  3MO2 A;  5TTF A;  4QEN A;  4YPA A;  3M58 A;  2R3A A;  4RZ0 A;  3RIB A;  3FPD A;  3RU0 A;  1MVH A;  5LSZ A;  4Z4P A;  3SWC A;  1N6C A;  5CCM A;  5KJK A;  1MVX A;  2G46 A;  4O6F A;  3OXG A;  4FMU A;  5HQ8 A;  5JHN A;  4WUY A;  3MEK A;  3M56 A;  5KJL A;  3MO5 A;  3CBO A;  5TEG A;  2W5Y A;  3K5K A;  1O9S A;  5JJ0 A;  5JIN A;  4E47 A;  3F9Y A;  4J83 A;  4H12 A;  2QPW A;  1MUF A;  1MT6 A;  4IJD A;  4QEP A;  3RQ4 A;  3F9X A;  3F9W A;  3KMA A;  2BQZ A;  4C1Q A;  3S7F A;  5HI7 A;  1XQH A;  5CPR B;  4QEO A;  3M53 A;  5KJN A;  1N6A A;  3QWW A;  3CBM A;  5EX0 A; 
#chains in the Genus database with same CATH topology
 3N71 A;  5T0K A;  2JV0 A;  5JIY A;  2RFI A;  2W5Z A;  3KMT A;  4NVQ A;  4YND A;  4J7F A;  5ARG A;  3HNA A;  4O30 A;  5CCL A;  3PDN A;  5AYF A;  5KJM A;  3OOI A;  4NJ5 A;  3CBP A;  4AU7 A;  3S8P A;  5F5E A;  4MI5 A;  1ML9 A;  2F69 A;  3OPE A;  4JLG A;  3OXL A;  4YPU A;  4JDS A;  3RAY A;  3S7J A;  4I51 A;  5LSX A;  3M55 A;  5ARF A;  5T0M A;  5EX3 A;  1N3J A;  5TH7 A;  5T5G A;  5EG2 A;  4MI0 A;  3SW9 A;  3VUZ A;  5F6L A;  3S7D A;  3OS5 A;  3EP0 A;  4IJ8 A;  4J7I A;  3IHX A;  3QWV A;  3TG4 A;  3DAL A;  3TG5 A;  2IGQ A;  4BUP A;  2O8J A;  3S7B A;  3DB5 A;  3M57 A;  3RJW A;  3F9Z A;  3OXF A;  4LDG A;  5F6K C;  4YNM A;  3M54 A;  4YNP A;  1H3I A;  3KMJ A;  1PEG A;  3BO5 A;  3M59 A;  3QWP A;  3M5A A;  4J8O A;  5F59 A;  4YPE A;  3MO0 A;  3VV0 A;  1ZKK A;  3MO2 A;  5TTF A;  4QEN A;  4YPA A;  3M58 A;  2R3A A;  4RZ0 A;  3RIB A;  3FPD A;  3RU0 A;  1MVH A;  5LSZ A;  4Z4P A;  3SWC A;  1N6C A;  5CCM A;  5KJK A;  1MVX A;  2G46 A;  4O6F A;  3OXG A;  4FMU A;  5HQ8 A;  5JHN A;  4WUY A;  3MEK A;  3M56 A;  5KJL A;  3MO5 A;  3CBO A;  5TEG A;  2W5Y A;  3K5K A;  1O9S A;  5JJ0 A;  5JIN A;  4E47 A;  3F9Y A;  4J83 A;  4H12 A;  2QPW A;  1MUF A;  1MT6 A;  4IJD A;  4QEP A;  3RQ4 A;  3F9X A;  3F9W A;  3KMA A;  2BQZ A;  4C1Q A;  3S7F A;  5HI7 A;  1XQH A;  5CPR B;  4QEO A;  3M53 A;  5KJN A;  1N6A A;  3QWW A;  3CBM A;  5EX0 A; 
#chains in the Genus database with same CATH homology
 3N71 A;  5T0K A;  2JV0 A;  5JIY A;  2RFI A;  2W5Z A;  3KMT A;  4NVQ A;  4YND A;  4J7F A;  5ARG A;  3HNA A;  4O30 A;  5CCL A;  3PDN A;  5AYF A;  5KJM A;  3OOI A;  4NJ5 A;  3CBP A;  4AU7 A;  3S8P A;  5F5E A;  4MI5 A;  1ML9 A;  2F69 A;  3OPE A;  4JLG A;  3OXL A;  4YPU A;  4JDS A;  3RAY A;  3S7J A;  4I51 A;  5LSX A;  3M55 A;  5ARF A;  5T0M A;  5EX3 A;  1N3J A;  5TH7 A;  5T5G A;  5EG2 A;  4MI0 A;  3SW9 A;  3VUZ A;  5F6L A;  3S7D A;  3OS5 A;  3EP0 A;  4IJ8 A;  4J7I A;  3IHX A;  3QWV A;  3TG4 A;  3DAL A;  3TG5 A;  2IGQ A;  4BUP A;  2O8J A;  3S7B A;  3DB5 A;  3M57 A;  3RJW A;  3F9Z A;  3OXF A;  4LDG A;  5F6K C;  4YNM A;  3M54 A;  4YNP A;  1H3I A;  3KMJ A;  1PEG A;  3BO5 A;  3M59 A;  3QWP A;  3M5A A;  4J8O A;  5F59 A;  4YPE A;  3MO0 A;  3VV0 A;  1ZKK A;  3MO2 A;  5TTF A;  4QEN A;  4YPA A;  3M58 A;  2R3A A;  4RZ0 A;  3RIB A;  3FPD A;  3RU0 A;  1MVH A;  5LSZ A;  4Z4P A;  3SWC A;  1N6C A;  5CCM A;  5KJK A;  1MVX A;  2G46 A;  4O6F A;  3OXG A;  4FMU A;  5HQ8 A;  5JHN A;  4WUY A;  3MEK A;  3M56 A;  5KJL A;  3MO5 A;  3CBO A;  5TEG A;  2W5Y A;  3K5K A;  1O9S A;  5JJ0 A;  5JIN A;  4E47 A;  3F9Y A;  4J83 A;  4H12 A;  2QPW A;  1MUF A;  1MT6 A;  4IJD A;  4QEP A;  3RQ4 A;  3F9X A;  3F9W A;  3KMA A;  2BQZ A;  4C1Q A;  3S7F A;  5HI7 A;  1XQH A;  5CPR B;  4QEO A;  3M53 A;  5KJN A;  1N6A A;  3QWW A;  3CBM A;  5EX0 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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