1MT6A

Structure of histone h3 k4-specific methyltransferase set7/9 with adohcy
Total Genus 62
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
62
sequence length
280
structure length
280
Chain Sequence
TLEGYYVDDALQGQGVYTYEDGGVLQGTYVDGELNGPAQEYDTDGRLIFKGQYKDNIRHGVCWIYYPDGGSLVGEVNEDGEMTGEKIAYVYPDERTALYGKFIDGEMIEGKLATLMSTEEGRPHFELMPGNSVYHFDKSTSSCISTNALLPDPYESERVYVAESLISSAGEGLFSKVAVGPNTVMSFYNGVRITHQEVDSRDWALNGNTLSLDEETVIDVPEPYNHVSKYCASLGHKANHSFTPNCIYDMFVHPRFGPIKCIRTLRAVEADEELTVAYGY
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The active site of the SET domain is constructed on a knot
pubmed rcsb
source organism Homo sapiens
molecule tags Transferase
molecule keywords SET9
total genus 62
structure length 280
sequence length 280
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2002-09-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF02493 MORN MORN repeat
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.20.110.10 Mainly Beta Single Sheet Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain 1mt6A01
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 1mt6A02
3TG5A 4BUPA 3OOIA 3M56A 5LSZA 3RIBA 5CCLA 3QWWA 5TEGA 2IGQA 4AU7A 1MUFA 2G46A 3BO5A 3M57A 5F59A 3OXFA 3DB5A 4NVQA 3PDNA 3RAYA 5TTFA 3KMAA 5ARFA 4O30A 3SW9A 4J8OA 3OXGA 5KJMA 3S7JA 3MO2A 4MI0A 3S7DA 3F9ZA 4NJ5A 5TH7A 3M54A 5EX0A 5EX3A 4O6FA 5KJLA 3TG4A 3RJWA 3S7BA 3F9YA 5CPRB 4J83A 4YPAA 4QEPA 5F5EA 5T0KA 3EP0A 3HNAA 4Z4PA 2F69A 3KMJA 5EG2A 5KJNA 3F9XA 3VV0A 3CBOA 4YNPA 2O8JA 3QWVA 5JHNA 1ML9A 2QPWA 4YPUA 4YNMA 3QWPA 2W5YA 4E47A 5JINA 4JLGA 3F9WA 4MI5A 3S7FA 3RU0A 1N6CA 5ARGA 5CCMA 5KJKA 4WUYA 4QEOA 4IJ8A 4YPEA 3DALA 3K5KA 3MEKA 3M55A 4IJDA 3RQ4A 1N6AA 2RFIA 5HI7A 5T5GA 1MT6A 4LDGA 1PEGA 3M59A 1N3JA 3M53A 3N71A 4FMUA 3IHXA 1MVXA 4J7IA 4I51A 2BQZA 4YNDA 3S8PA 3FPDA 2JV0A 4JDSA 3M5AA 3CBMA 3MO5A 3CBPA 3KMTA 5F6KC 4RZ0A 4QENA 5JIYA 3OPEA 3M58A 5F6LA 3SWCA 1XQHA 4H12A 3OXLA 3VUZA 5AYFA 1H3IA 1ZKKA 3OS5A 2W5ZA 5JJ0A 3MO0A 2R3AA 4J7FA 5T0MA 4C1QA 1O9SA 5HQ8A 5LSXA 1MVHA
chains in the Genus database with same CATH superfamily
3TG5A 4BUPA 3OOIA 3M56A 5LSZA 3RIBA 5CCLA 3QWWA 5TEGA 2IGQA 4AU7A 1MUFA 2G46A 3BO5A 3M57A 5F59A 3OXFA 3DB5A 4NVQA 3PDNA 3RAYA 5TTFA 3KMAA 5ARFA 4O30A 3SW9A 4J8OA 3OXGA 5KJMA 3S7JA 3MO2A 4MI0A 3S7DA 3F9ZA 4NJ5A 5TH7A 3M54A 5EX0A 5EX3A 4O6FA 5KJLA 3TG4A 3RJWA 3S7BA 3F9YA 5CPRB 4J83A 4YPAA 4QEPA 5F5EA 5T0KA 3EP0A 3HNAA 4Z4PA 2F69A 3KMJA 5EG2A 5KJNA 3F9XA 3VV0A 3CBOA 4YNPA 2O8JA 3QWVA 5JHNA 1ML9A 2QPWA 4YPUA 4YNMA 3QWPA 2W5YA 4E47A 5JINA 4JLGA 3F9WA 4MI5A 3S7FA 3RU0A 1N6CA 5ARGA 5CCMA 5KJKA 4WUYA 4QEOA 4IJ8A 4YPEA 3DALA 3K5KA 3MEKA 3M55A 4IJDA 3RQ4A 1N6AA 2RFIA 5HI7A 5T5GA 1MT6A 4LDGA 1PEGA 3M59A 1N3JA 3M53A 3N71A 4FMUA 3IHXA 1MVXA 4J7IA 4I51A 2BQZA 4YNDA 3S8PA 3FPDA 2JV0A 4JDSA 3M5AA 3CBMA 3MO5A 3CBPA 3KMTA 5F6KC 4RZ0A 4QENA 5JIYA 3OPEA 3M58A 5F6LA 3SWCA 1XQHA 4H12A 3OXLA 3VUZA 5AYFA 1H3IA 1ZKKA 3OS5A 2W5ZA 5JJ0A 3MO0A 2R3AA 4J7FA 5T0MA 4C1QA 1O9SA 5HQ8A 5LSXA 1MVHA
chains in the Genus database with same CATH topology
3TG5A 4BUPA 3OOIA 3M56A 5LSZA 3RIBA 5CCLA 3QWWA 5TEGA 2IGQA 4AU7A 1MUFA 2G46A 3BO5A 3M57A 5F59A 3OXFA 3DB5A 4NVQA 3PDNA 3RAYA 5TTFA 3KMAA 5ARFA 4O30A 3SW9A 4J8OA 3OXGA 5KJMA 3S7JA 3MO2A 4MI0A 3S7DA 3F9ZA 4NJ5A 5TH7A 3M54A 5EX0A 5EX3A 4O6FA 5KJLA 3TG4A 3RJWA 3S7BA 3F9YA 5CPRB 4J83A 4YPAA 4QEPA 5F5EA 5T0KA 3EP0A 3HNAA 4Z4PA 2F69A 3KMJA 5EG2A 5KJNA 3F9XA 3VV0A 3CBOA 4YNPA 2O8JA 3QWVA 5JHNA 1ML9A 2QPWA 4YPUA 4YNMA 3QWPA 2W5YA 4E47A 5JINA 4JLGA 3F9WA 4MI5A 3S7FA 3RU0A 1N6CA 5ARGA 5CCMA 5KJKA 4WUYA 4QEOA 4IJ8A 4YPEA 3DALA 3K5KA 3MEKA 3M55A 4IJDA 3RQ4A 1N6AA 2RFIA 5HI7A 5T5GA 1MT6A 4LDGA 1PEGA 3M59A 1N3JA 3M53A 3N71A 4FMUA 3IHXA 1MVXA 4J7IA 4I51A 2BQZA 4YNDA 3S8PA 3FPDA 2JV0A 4JDSA 3M5AA 3CBMA 3MO5A 3CBPA 3KMTA 5F6KC 4RZ0A 4QENA 5JIYA 3OPEA 3M58A 5F6LA 3SWCA 1XQHA 4H12A 3OXLA 3VUZA 5AYFA 1H3IA 1ZKKA 3OS5A 2W5ZA 5JJ0A 3MO0A 2R3AA 4J7FA 5T0MA 4C1QA 1O9SA 5HQ8A 5LSXA 1MVHA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3TG5 A;  4BUP A;  3OOI A;  3M56 A;  5LSZ A;  3RIB A;  5CCL A;  3QWW A;  5TEG A;  2IGQ A;  4AU7 A;  1MUF A;  2G46 A;  3BO5 A;  3M57 A;  5F59 A;  3OXF A;  3DB5 A;  4NVQ A;  3PDN A;  3RAY A;  5TTF A;  3KMA A;  5ARF A;  4O30 A;  3SW9 A;  4J8O A;  3OXG A;  5KJM A;  3S7J A;  3MO2 A;  4MI0 A;  3S7D A;  3F9Z A;  4NJ5 A;  5TH7 A;  3M54 A;  5EX0 A;  5EX3 A;  4O6F A;  5KJL A;  3TG4 A;  3RJW A;  3S7B A;  3F9Y A;  5CPR B;  4J83 A;  4YPA A;  4QEP A;  5F5E A;  5T0K A;  3EP0 A;  3HNA A;  4Z4P A;  2F69 A;  3KMJ A;  5EG2 A;  5KJN A;  3F9X A;  3VV0 A;  3CBO A;  4YNP A;  2O8J A;  3QWV A;  5JHN A;  1ML9 A;  2QPW A;  4YPU A;  4YNM A;  3QWP A;  2W5Y A;  4E47 A;  5JIN A;  4JLG A;  3F9W A;  4MI5 A;  3S7F A;  3RU0 A;  1N6C A;  5ARG A;  5CCM A;  5KJK A;  4WUY A;  4QEO A;  4IJ8 A;  4YPE A;  3DAL A;  3K5K A;  3MEK A;  3M55 A;  4IJD A;  3RQ4 A;  1N6A A;  2RFI A;  5HI7 A;  5T5G A;  1MT6 A;  4LDG A;  1PEG A;  3M59 A;  1N3J A;  3M53 A;  3N71 A;  4FMU A;  3IHX A;  1MVX A;  4J7I A;  4I51 A;  2BQZ A;  4YND A;  3S8P A;  3FPD A;  2JV0 A;  4JDS A;  3M5A A;  3CBM A;  3MO5 A;  3CBP A;  3KMT A;  5F6K C;  4RZ0 A;  4QEN A;  5JIY A;  3OPE A;  3M58 A;  5F6L A;  3SWC A;  1XQH A;  4H12 A;  3OXL A;  3VUZ A;  5AYF A;  1H3I A;  1ZKK A;  3OS5 A;  2W5Z A;  5JJ0 A;  3MO0 A;  2R3A A;  4J7F A;  5T0M A;  4C1Q A;  1O9S A;  5HQ8 A;  5LSX A;  1MVH A; 
#chains in the Genus database with same CATH topology
 3TG5 A;  4BUP A;  3OOI A;  3M56 A;  5LSZ A;  3RIB A;  5CCL A;  3QWW A;  5TEG A;  2IGQ A;  4AU7 A;  1MUF A;  2G46 A;  3BO5 A;  3M57 A;  5F59 A;  3OXF A;  3DB5 A;  4NVQ A;  3PDN A;  3RAY A;  5TTF A;  3KMA A;  5ARF A;  4O30 A;  3SW9 A;  4J8O A;  3OXG A;  5KJM A;  3S7J A;  3MO2 A;  4MI0 A;  3S7D A;  3F9Z A;  4NJ5 A;  5TH7 A;  3M54 A;  5EX0 A;  5EX3 A;  4O6F A;  5KJL A;  3TG4 A;  3RJW A;  3S7B A;  3F9Y A;  5CPR B;  4J83 A;  4YPA A;  4QEP A;  5F5E A;  5T0K A;  3EP0 A;  3HNA A;  4Z4P A;  2F69 A;  3KMJ A;  5EG2 A;  5KJN A;  3F9X A;  3VV0 A;  3CBO A;  4YNP A;  2O8J A;  3QWV A;  5JHN A;  1ML9 A;  2QPW A;  4YPU A;  4YNM A;  3QWP A;  2W5Y A;  4E47 A;  5JIN A;  4JLG A;  3F9W A;  4MI5 A;  3S7F A;  3RU0 A;  1N6C A;  5ARG A;  5CCM A;  5KJK A;  4WUY A;  4QEO A;  4IJ8 A;  4YPE A;  3DAL A;  3K5K A;  3MEK A;  3M55 A;  4IJD A;  3RQ4 A;  1N6A A;  2RFI A;  5HI7 A;  5T5G A;  1MT6 A;  4LDG A;  1PEG A;  3M59 A;  1N3J A;  3M53 A;  3N71 A;  4FMU A;  3IHX A;  1MVX A;  4J7I A;  4I51 A;  2BQZ A;  4YND A;  3S8P A;  3FPD A;  2JV0 A;  4JDS A;  3M5A A;  3CBM A;  3MO5 A;  3CBP A;  3KMT A;  5F6K C;  4RZ0 A;  4QEN A;  5JIY A;  3OPE A;  3M58 A;  5F6L A;  3SWC A;  1XQH A;  4H12 A;  3OXL A;  3VUZ A;  5AYF A;  1H3I A;  1ZKK A;  3OS5 A;  2W5Z A;  5JJ0 A;  3MO0 A;  2R3A A;  4J7F A;  5T0M A;  4C1Q A;  1O9S A;  5HQ8 A;  5LSX A;  1MVH A; 
#chains in the Genus database with same CATH homology
 3TG5 A;  4BUP A;  3OOI A;  3M56 A;  5LSZ A;  3RIB A;  5CCL A;  3QWW A;  5TEG A;  2IGQ A;  4AU7 A;  1MUF A;  2G46 A;  3BO5 A;  3M57 A;  5F59 A;  3OXF A;  3DB5 A;  4NVQ A;  3PDN A;  3RAY A;  5TTF A;  3KMA A;  5ARF A;  4O30 A;  3SW9 A;  4J8O A;  3OXG A;  5KJM A;  3S7J A;  3MO2 A;  4MI0 A;  3S7D A;  3F9Z A;  4NJ5 A;  5TH7 A;  3M54 A;  5EX0 A;  5EX3 A;  4O6F A;  5KJL A;  3TG4 A;  3RJW A;  3S7B A;  3F9Y A;  5CPR B;  4J83 A;  4YPA A;  4QEP A;  5F5E A;  5T0K A;  3EP0 A;  3HNA A;  4Z4P A;  2F69 A;  3KMJ A;  5EG2 A;  5KJN A;  3F9X A;  3VV0 A;  3CBO A;  4YNP A;  2O8J A;  3QWV A;  5JHN A;  1ML9 A;  2QPW A;  4YPU A;  4YNM A;  3QWP A;  2W5Y A;  4E47 A;  5JIN A;  4JLG A;  3F9W A;  4MI5 A;  3S7F A;  3RU0 A;  1N6C A;  5ARG A;  5CCM A;  5KJK A;  4WUY A;  4QEO A;  4IJ8 A;  4YPE A;  3DAL A;  3K5K A;  3MEK A;  3M55 A;  4IJD A;  3RQ4 A;  1N6A A;  2RFI A;  5HI7 A;  5T5G A;  1MT6 A;  4LDG A;  1PEG A;  3M59 A;  1N3J A;  3M53 A;  3N71 A;  4FMU A;  3IHX A;  1MVX A;  4J7I A;  4I51 A;  2BQZ A;  4YND A;  3S8P A;  3FPD A;  2JV0 A;  4JDS A;  3M5A A;  3CBM A;  3MO5 A;  3CBP A;  3KMT A;  5F6K C;  4RZ0 A;  4QEN A;  5JIY A;  3OPE A;  3M58 A;  5F6L A;  3SWC A;  1XQH A;  4H12 A;  3OXL A;  3VUZ A;  5AYF A;  1H3I A;  1ZKK A;  3OS5 A;  2W5Z A;  5JJ0 A;  3MO0 A;  2R3A A;  4J7F A;  5T0M A;  4C1Q A;  1O9S A;  5HQ8 A;  5LSX A;  1MVH A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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