1MT6A

Structure of histone h3 k4-specific methyltransferase set7/9 with adohcy
Total Genus 62
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
62
sequence length
280
structure length
280
Chain Sequence
b'TLEGYYVDDALQGQGVYTYEDGGVLQGTYVDGELNGPAQEYDTDGRLIFKGQYKDNIRHGVCWIYYPDGGSLVGEVNEDGEMTGEKIAYVYPDERTALYGKFIDGEMIEGKLATLMSTEEGRPHFELMPGNSVYHFDKSTSSCISTNALLPDPYESERVYVAESLISSAGEGLFSKVAVGPNTVMSFYNGVRITHQEVDSRDWALNGNTLSLDEETVIDVPEPYNHVSKYCASLGHKANHSFTPNCIYDMFVHPRFGPIKCIRTLRAVEADEELTVAYGY'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords SET9
molecule tags Transferase
source organism Homo sapiens
publication title The active site of the SET domain is constructed on a knot
pubmed rcsb
total genus 62
structure length 280
sequence length 280
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2002-09-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF02493 MORN MORN repeat
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.20.110.10 Mainly Beta Single Sheet Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain 1mt6A01
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 1mt6A02
5F59A 3SWCA 1H3IA 3F9ZA 2RFIA 3CBOA 5JJ0A 3F9XA 3S7BA 1N6AA 3VUZA 2QPWA 1N6CA 5EG2A 4MI0A 4AU7A 4IJ8A 5LSXA 3OXGA 1O9SA 3DB5A 3EP0A 5T0KA 3M53A 3MO5A 3F9WA 4WUYA 3OOIA 1N3JA 4Z4PA 3S7FA 3MEKA 3M5AA 3RQ4A 3KMTA 3KMJA 4LDGA 2W5YA 3M57A 4J83A 4IJDA 4J8OA 1PEGA 5CPRB 3QWPA 3OXFA 3IHXA 3RIBA 5JIYA 4QEOA 4YPUA 1MT6A 3M58A 4I51A 4NJ5A 5F5EA 3OPEA 3VV0A 4YNPA 4BUPA 4RZ0A 5CCMA 3SW9A 3MO2A 5EX0A 3QWVA 3M54A 3OS5A 4NVQA 4YNDA 2JV0A 4H12A 3KMAA 5KJMA 5LSZA 1MUFA 3TG5A 3S7DA 5ARGA 3CBPA 3RU0A 4J7FA 5T5GA 1XQHA 4O6FA 5JHNA 3PDNA 3RJWA 4C1QA 5TEGA 3OXLA 4O30A 5ARFA 4YNMA 2W5ZA 1MVXA 5TH7A 5AYFA 3S8PA 3TG4A 5F6LA 4YPAA 3QWWA 3M56A 2R3AA 3M55A 1ZKKA 3S7JA 1MVHA 5KJNA 5TTFA 5T0MA 2BQZA 5CCLA 5HQ8A 2F69A 4QENA 3CBMA 3MO0A 4QEPA 4JDSA 5KJLA 2IGQA 3BO5A 5HI7A 5KJKA 3K5KA 4E47A 5F6KC 5JINA 2O8JA 4MI5A 5EX3A 4FMUA 4YPEA 2G46A 3HNAA 3FPDA 3N71A 1ML9A 4J7IA 3DALA 4JLGA 3RAYA 3M59A 3F9YA
chains in the Genus database with same CATH superfamily
5F59A 3SWCA 1H3IA 3F9ZA 2RFIA 3CBOA 5JJ0A 3F9XA 3S7BA 1N6AA 3VUZA 2QPWA 1N6CA 5EG2A 4MI0A 4AU7A 4IJ8A 5LSXA 3OXGA 1O9SA 3DB5A 3EP0A 5T0KA 3M53A 3MO5A 3F9WA 4WUYA 3OOIA 1N3JA 4Z4PA 3S7FA 3MEKA 3M5AA 3RQ4A 3KMTA 3KMJA 4LDGA 2W5YA 3M57A 4J83A 4IJDA 4J8OA 1PEGA 5CPRB 3QWPA 3OXFA 3IHXA 3RIBA 5JIYA 4QEOA 4YPUA 1MT6A 3M58A 4I51A 4NJ5A 5F5EA 3OPEA 3VV0A 4YNPA 4BUPA 4RZ0A 5CCMA 3SW9A 3MO2A 5EX0A 3QWVA 3M54A 3OS5A 4NVQA 4YNDA 2JV0A 4H12A 3KMAA 5KJMA 5LSZA 1MUFA 3TG5A 3S7DA 5ARGA 3CBPA 3RU0A 4J7FA 5T5GA 1XQHA 4O6FA 5JHNA 3PDNA 3RJWA 4C1QA 5TEGA 3OXLA 4O30A 5ARFA 4YNMA 2W5ZA 1MVXA 5TH7A 5AYFA 3S8PA 3TG4A 5F6LA 4YPAA 3QWWA 3M56A 2R3AA 3M55A 1ZKKA 3S7JA 1MVHA 5KJNA 5TTFA 5T0MA 2BQZA 5CCLA 5HQ8A 2F69A 4QENA 3CBMA 3MO0A 4QEPA 4JDSA 5KJLA 2IGQA 3BO5A 5HI7A 5KJKA 3K5KA 4E47A 5F6KC 5JINA 2O8JA 4MI5A 5EX3A 4FMUA 4YPEA 2G46A 3HNAA 3FPDA 3N71A 1ML9A 4J7IA 3DALA 4JLGA 3RAYA 3M59A 3F9YA
chains in the Genus database with same CATH topology
5F59A 3SWCA 1H3IA 3F9ZA 2RFIA 3CBOA 5JJ0A 3F9XA 3S7BA 1N6AA 3VUZA 2QPWA 1N6CA 5EG2A 4MI0A 4AU7A 4IJ8A 5LSXA 3OXGA 1O9SA 3DB5A 3EP0A 5T0KA 3M53A 3MO5A 3F9WA 4WUYA 3OOIA 1N3JA 4Z4PA 3S7FA 3MEKA 3M5AA 3RQ4A 3KMTA 3KMJA 4LDGA 2W5YA 3M57A 4J83A 4IJDA 4J8OA 1PEGA 5CPRB 3QWPA 3OXFA 3IHXA 3RIBA 5JIYA 4QEOA 4YPUA 1MT6A 3M58A 4I51A 4NJ5A 5F5EA 3OPEA 3VV0A 4YNPA 4BUPA 4RZ0A 5CCMA 3SW9A 3MO2A 5EX0A 3QWVA 3M54A 3OS5A 4NVQA 4YNDA 2JV0A 4H12A 3KMAA 5KJMA 5LSZA 1MUFA 3TG5A 3S7DA 5ARGA 3CBPA 3RU0A 4J7FA 5T5GA 1XQHA 4O6FA 5JHNA 3PDNA 3RJWA 4C1QA 5TEGA 3OXLA 4O30A 5ARFA 4YNMA 2W5ZA 1MVXA 5TH7A 5AYFA 3S8PA 3TG4A 5F6LA 4YPAA 3QWWA 3M56A 2R3AA 3M55A 1ZKKA 3S7JA 1MVHA 5KJNA 5TTFA 5T0MA 2BQZA 5CCLA 5HQ8A 2F69A 4QENA 3CBMA 3MO0A 4QEPA 4JDSA 5KJLA 2IGQA 3BO5A 5HI7A 5KJKA 3K5KA 4E47A 5F6KC 5JINA 2O8JA 4MI5A 5EX3A 4FMUA 4YPEA 2G46A 3HNAA 3FPDA 3N71A 1ML9A 4J7IA 3DALA 4JLGA 3RAYA 3M59A 3F9YA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5F59 A;  3SWC A;  1H3I A;  3F9Z A;  2RFI A;  3CBO A;  5JJ0 A;  3F9X A;  3S7B A;  1N6A A;  3VUZ A;  2QPW A;  1N6C A;  5EG2 A;  4MI0 A;  4AU7 A;  4IJ8 A;  5LSX A;  3OXG A;  1O9S A;  3DB5 A;  3EP0 A;  5T0K A;  3M53 A;  3MO5 A;  3F9W A;  4WUY A;  3OOI A;  1N3J A;  4Z4P A;  3S7F A;  3MEK A;  3M5A A;  3RQ4 A;  3KMT A;  3KMJ A;  4LDG A;  2W5Y A;  3M57 A;  4J83 A;  4IJD A;  4J8O A;  1PEG A;  5CPR B;  3QWP A;  3OXF A;  3IHX A;  3RIB A;  5JIY A;  4QEO A;  4YPU A;  1MT6 A;  3M58 A;  4I51 A;  4NJ5 A;  5F5E A;  3OPE A;  3VV0 A;  4YNP A;  4BUP A;  4RZ0 A;  5CCM A;  3SW9 A;  3MO2 A;  5EX0 A;  3QWV A;  3M54 A;  3OS5 A;  4NVQ A;  4YND A;  2JV0 A;  4H12 A;  3KMA A;  5KJM A;  5LSZ A;  1MUF A;  3TG5 A;  3S7D A;  5ARG A;  3CBP A;  3RU0 A;  4J7F A;  5T5G A;  1XQH A;  4O6F A;  5JHN A;  3PDN A;  3RJW A;  4C1Q A;  5TEG A;  3OXL A;  4O30 A;  5ARF A;  4YNM A;  2W5Z A;  1MVX A;  5TH7 A;  5AYF A;  3S8P A;  3TG4 A;  5F6L A;  4YPA A;  3QWW A;  3M56 A;  2R3A A;  3M55 A;  1ZKK A;  3S7J A;  1MVH A;  5KJN A;  5TTF A;  5T0M A;  2BQZ A;  5CCL A;  5HQ8 A;  2F69 A;  4QEN A;  3CBM A;  3MO0 A;  4QEP A;  4JDS A;  5KJL A;  2IGQ A;  3BO5 A;  5HI7 A;  5KJK A;  3K5K A;  4E47 A;  5F6K C;  5JIN A;  2O8J A;  4MI5 A;  5EX3 A;  4FMU A;  4YPE A;  2G46 A;  3HNA A;  3FPD A;  3N71 A;  1ML9 A;  4J7I A;  3DAL A;  4JLG A;  3RAY A;  3M59 A;  3F9Y A; 
#chains in the Genus database with same CATH topology
 5F59 A;  3SWC A;  1H3I A;  3F9Z A;  2RFI A;  3CBO A;  5JJ0 A;  3F9X A;  3S7B A;  1N6A A;  3VUZ A;  2QPW A;  1N6C A;  5EG2 A;  4MI0 A;  4AU7 A;  4IJ8 A;  5LSX A;  3OXG A;  1O9S A;  3DB5 A;  3EP0 A;  5T0K A;  3M53 A;  3MO5 A;  3F9W A;  4WUY A;  3OOI A;  1N3J A;  4Z4P A;  3S7F A;  3MEK A;  3M5A A;  3RQ4 A;  3KMT A;  3KMJ A;  4LDG A;  2W5Y A;  3M57 A;  4J83 A;  4IJD A;  4J8O A;  1PEG A;  5CPR B;  3QWP A;  3OXF A;  3IHX A;  3RIB A;  5JIY A;  4QEO A;  4YPU A;  1MT6 A;  3M58 A;  4I51 A;  4NJ5 A;  5F5E A;  3OPE A;  3VV0 A;  4YNP A;  4BUP A;  4RZ0 A;  5CCM A;  3SW9 A;  3MO2 A;  5EX0 A;  3QWV A;  3M54 A;  3OS5 A;  4NVQ A;  4YND A;  2JV0 A;  4H12 A;  3KMA A;  5KJM A;  5LSZ A;  1MUF A;  3TG5 A;  3S7D A;  5ARG A;  3CBP A;  3RU0 A;  4J7F A;  5T5G A;  1XQH A;  4O6F A;  5JHN A;  3PDN A;  3RJW A;  4C1Q A;  5TEG A;  3OXL A;  4O30 A;  5ARF A;  4YNM A;  2W5Z A;  1MVX A;  5TH7 A;  5AYF A;  3S8P A;  3TG4 A;  5F6L A;  4YPA A;  3QWW A;  3M56 A;  2R3A A;  3M55 A;  1ZKK A;  3S7J A;  1MVH A;  5KJN A;  5TTF A;  5T0M A;  2BQZ A;  5CCL A;  5HQ8 A;  2F69 A;  4QEN A;  3CBM A;  3MO0 A;  4QEP A;  4JDS A;  5KJL A;  2IGQ A;  3BO5 A;  5HI7 A;  5KJK A;  3K5K A;  4E47 A;  5F6K C;  5JIN A;  2O8J A;  4MI5 A;  5EX3 A;  4FMU A;  4YPE A;  2G46 A;  3HNA A;  3FPD A;  3N71 A;  1ML9 A;  4J7I A;  3DAL A;  4JLG A;  3RAY A;  3M59 A;  3F9Y A; 
#chains in the Genus database with same CATH homology
 5F59 A;  3SWC A;  1H3I A;  3F9Z A;  2RFI A;  3CBO A;  5JJ0 A;  3F9X A;  3S7B A;  1N6A A;  3VUZ A;  2QPW A;  1N6C A;  5EG2 A;  4MI0 A;  4AU7 A;  4IJ8 A;  5LSX A;  3OXG A;  1O9S A;  3DB5 A;  3EP0 A;  5T0K A;  3M53 A;  3MO5 A;  3F9W A;  4WUY A;  3OOI A;  1N3J A;  4Z4P A;  3S7F A;  3MEK A;  3M5A A;  3RQ4 A;  3KMT A;  3KMJ A;  4LDG A;  2W5Y A;  3M57 A;  4J83 A;  4IJD A;  4J8O A;  1PEG A;  5CPR B;  3QWP A;  3OXF A;  3IHX A;  3RIB A;  5JIY A;  4QEO A;  4YPU A;  1MT6 A;  3M58 A;  4I51 A;  4NJ5 A;  5F5E A;  3OPE A;  3VV0 A;  4YNP A;  4BUP A;  4RZ0 A;  5CCM A;  3SW9 A;  3MO2 A;  5EX0 A;  3QWV A;  3M54 A;  3OS5 A;  4NVQ A;  4YND A;  2JV0 A;  4H12 A;  3KMA A;  5KJM A;  5LSZ A;  1MUF A;  3TG5 A;  3S7D A;  5ARG A;  3CBP A;  3RU0 A;  4J7F A;  5T5G A;  1XQH A;  4O6F A;  5JHN A;  3PDN A;  3RJW A;  4C1Q A;  5TEG A;  3OXL A;  4O30 A;  5ARF A;  4YNM A;  2W5Z A;  1MVX A;  5TH7 A;  5AYF A;  3S8P A;  3TG4 A;  5F6L A;  4YPA A;  3QWW A;  3M56 A;  2R3A A;  3M55 A;  1ZKK A;  3S7J A;  1MVH A;  5KJN A;  5TTF A;  5T0M A;  2BQZ A;  5CCL A;  5HQ8 A;  2F69 A;  4QEN A;  3CBM A;  3MO0 A;  4QEP A;  4JDS A;  5KJL A;  2IGQ A;  3BO5 A;  5HI7 A;  5KJK A;  3K5K A;  4E47 A;  5F6K C;  5JIN A;  2O8J A;  4MI5 A;  5EX3 A;  4FMU A;  4YPE A;  2G46 A;  3HNA A;  3FPD A;  3N71 A;  1ML9 A;  4J7I A;  3DAL A;  4JLG A;  3RAY A;  3M59 A;  3F9Y A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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