1MT6A

Structure of histone h3 k4-specific methyltransferase set7/9 with adohcy
Total Genus 62
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
62
sequence length
280
structure length
280
Chain Sequence
TLEGYYVDDALQGQGVYTYEDGGVLQGTYVDGELNGPAQEYDTDGRLIFKGQYKDNIRHGVCWIYYPDGGSLVGEVNEDGEMTGEKIAYVYPDERTALYGKFIDGEMIEGKLATLMSTEEGRPHFELMPGNSVYHFDKSTSSCISTNALLPDPYESERVYVAESLISSAGEGLFSKVAVGPNTVMSFYNGVRITHQEVDSRDWALNGNTLSLDEETVIDVPEPYNHVSKYCASLGHKANHSFTPNCIYDMFVHPRFGPIKCIRTLRAVEADEELTVAYGY
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Transferase
molecule keywords SET9
publication title The active site of the SET domain is constructed on a knot
pubmed rcsb
source organism Homo sapiens
total genus 62
structure length 280
sequence length 280
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2002-09-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF02493 MORN MORN repeat
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.20.110.10 Mainly Beta Single Sheet Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain 1mt6A01
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 1mt6A02
3S7DA 4LDGA 3HNAA 3OXFA 4IJDA 3S7BA 3SWCA 1MVXA 3CBPA 3M57A 3K5KA 1H3IA 5ARGA 1MT6A 3S7FA 3RQ4A 3OS5A 4C1QA 3F9WA 3OXLA 5ARFA 4J8OA 3MO0A 1O9SA 1N6CA 5HQ8A 4NJ5A 3QWWA 5T0MA 3RJWA 5KJKA 5CCMA 3OPEA 5LSXA 3M59A 4AU7A 2O8JA 4E47A 3SW9A 4MI5A 3CBMA 2BQZA 4QENA 4YNDA 5JHNA 1N3JA 3KMTA 4MI0A 4QEOA 5F6KC 5AYFA 5EG2A 4Z4PA 4I51A 3IHXA 4JDSA 4IJ8A 3N71A 3VV0A 5T0KA 2F69A 3F9YA 5HI7A 5KJNA 3RAYA 4O30A 3BO5A 4YPEA 4YNPA 2QPWA 4O6FA 4YNMA 4J83A 5JINA 4YPUA 2R3AA 5EX3A 5TH7A 3RU0A 3KMAA 3S8PA 2G46A 3MEKA 3EP0A 5F6LA 4J7FA 1ML9A 2W5YA 3M54A 5TTFA 1MUFA 4NVQA 4BUPA 5JIYA 3M56A 3F9XA 1ZKKA 5KJMA 3S7JA 2RFIA 5KJLA 5EX0A 3M55A 3KMJA 2W5ZA 2IGQA 3M58A 3VUZA 3CBOA 4JLGA 4YPAA 3DALA 3M5AA 5TEGA 4QEPA 3OXGA 3FPDA 1N6AA 5JJ0A 4WUYA 4J7IA 1XQHA 3F9ZA 3QWPA 3DB5A 5F59A 2JV0A 3TG5A 1PEGA 4FMUA 5T5GA 3MO2A 3OOIA 3QWVA 5LSZA 5F5EA 1MVHA 3TG4A 3MO5A 4RZ0A 3M53A 3PDNA 5CPRB 4H12A 5CCLA 3RIBA
chains in the Genus database with same CATH superfamily
3S7DA 4LDGA 3HNAA 3OXFA 4IJDA 3S7BA 3SWCA 1MVXA 3CBPA 3M57A 3K5KA 1H3IA 5ARGA 1MT6A 3S7FA 3RQ4A 3OS5A 4C1QA 3F9WA 3OXLA 5ARFA 4J8OA 3MO0A 1O9SA 1N6CA 5HQ8A 4NJ5A 3QWWA 5T0MA 3RJWA 5KJKA 5CCMA 3OPEA 5LSXA 3M59A 4AU7A 2O8JA 4E47A 3SW9A 4MI5A 3CBMA 2BQZA 4QENA 4YNDA 5JHNA 1N3JA 3KMTA 4MI0A 4QEOA 5F6KC 5AYFA 5EG2A 4Z4PA 4I51A 3IHXA 4JDSA 4IJ8A 3N71A 3VV0A 5T0KA 2F69A 3F9YA 5HI7A 5KJNA 3RAYA 4O30A 3BO5A 4YPEA 4YNPA 2QPWA 4O6FA 4YNMA 4J83A 5JINA 4YPUA 2R3AA 5EX3A 5TH7A 3RU0A 3KMAA 3S8PA 2G46A 3MEKA 3EP0A 5F6LA 4J7FA 1ML9A 2W5YA 3M54A 5TTFA 1MUFA 4NVQA 4BUPA 5JIYA 3M56A 3F9XA 1ZKKA 5KJMA 3S7JA 2RFIA 5KJLA 5EX0A 3M55A 3KMJA 2W5ZA 2IGQA 3M58A 3VUZA 3CBOA 4JLGA 4YPAA 3DALA 3M5AA 5TEGA 4QEPA 3OXGA 3FPDA 1N6AA 5JJ0A 4WUYA 4J7IA 1XQHA 3F9ZA 3QWPA 3DB5A 5F59A 2JV0A 3TG5A 1PEGA 4FMUA 5T5GA 3MO2A 3OOIA 3QWVA 5LSZA 5F5EA 1MVHA 3TG4A 3MO5A 4RZ0A 3M53A 3PDNA 5CPRB 4H12A 5CCLA 3RIBA
chains in the Genus database with same CATH topology
3S7DA 4LDGA 3HNAA 3OXFA 4IJDA 3S7BA 3SWCA 1MVXA 3CBPA 3M57A 3K5KA 1H3IA 5ARGA 1MT6A 3S7FA 3RQ4A 3OS5A 4C1QA 3F9WA 3OXLA 5ARFA 4J8OA 3MO0A 1O9SA 1N6CA 5HQ8A 4NJ5A 3QWWA 5T0MA 3RJWA 5KJKA 5CCMA 3OPEA 5LSXA 3M59A 4AU7A 2O8JA 4E47A 3SW9A 4MI5A 3CBMA 2BQZA 4QENA 4YNDA 5JHNA 1N3JA 3KMTA 4MI0A 4QEOA 5F6KC 5AYFA 5EG2A 4Z4PA 4I51A 3IHXA 4JDSA 4IJ8A 3N71A 3VV0A 5T0KA 2F69A 3F9YA 5HI7A 5KJNA 3RAYA 4O30A 3BO5A 4YPEA 4YNPA 2QPWA 4O6FA 4YNMA 4J83A 5JINA 4YPUA 2R3AA 5EX3A 5TH7A 3RU0A 3KMAA 3S8PA 2G46A 3MEKA 3EP0A 5F6LA 4J7FA 1ML9A 2W5YA 3M54A 5TTFA 1MUFA 4NVQA 4BUPA 5JIYA 3M56A 3F9XA 1ZKKA 5KJMA 3S7JA 2RFIA 5KJLA 5EX0A 3M55A 3KMJA 2W5ZA 2IGQA 3M58A 3VUZA 3CBOA 4JLGA 4YPAA 3DALA 3M5AA 5TEGA 4QEPA 3OXGA 3FPDA 1N6AA 5JJ0A 4WUYA 4J7IA 1XQHA 3F9ZA 3QWPA 3DB5A 5F59A 2JV0A 3TG5A 1PEGA 4FMUA 5T5GA 3MO2A 3OOIA 3QWVA 5LSZA 5F5EA 1MVHA 3TG4A 3MO5A 4RZ0A 3M53A 3PDNA 5CPRB 4H12A 5CCLA 3RIBA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3S7D A;  4LDG A;  3HNA A;  3OXF A;  4IJD A;  3S7B A;  3SWC A;  1MVX A;  3CBP A;  3M57 A;  3K5K A;  1H3I A;  5ARG A;  1MT6 A;  3S7F A;  3RQ4 A;  3OS5 A;  4C1Q A;  3F9W A;  3OXL A;  5ARF A;  4J8O A;  3MO0 A;  1O9S A;  1N6C A;  5HQ8 A;  4NJ5 A;  3QWW A;  5T0M A;  3RJW A;  5KJK A;  5CCM A;  3OPE A;  5LSX A;  3M59 A;  4AU7 A;  2O8J A;  4E47 A;  3SW9 A;  4MI5 A;  3CBM A;  2BQZ A;  4QEN A;  4YND A;  5JHN A;  1N3J A;  3KMT A;  4MI0 A;  4QEO A;  5F6K C;  5AYF A;  5EG2 A;  4Z4P A;  4I51 A;  3IHX A;  4JDS A;  4IJ8 A;  3N71 A;  3VV0 A;  5T0K A;  2F69 A;  3F9Y A;  5HI7 A;  5KJN A;  3RAY A;  4O30 A;  3BO5 A;  4YPE A;  4YNP A;  2QPW A;  4O6F A;  4YNM A;  4J83 A;  5JIN A;  4YPU A;  2R3A A;  5EX3 A;  5TH7 A;  3RU0 A;  3KMA A;  3S8P A;  2G46 A;  3MEK A;  3EP0 A;  5F6L A;  4J7F A;  1ML9 A;  2W5Y A;  3M54 A;  5TTF A;  1MUF A;  4NVQ A;  4BUP A;  5JIY A;  3M56 A;  3F9X A;  1ZKK A;  5KJM A;  3S7J A;  2RFI A;  5KJL A;  5EX0 A;  3M55 A;  3KMJ A;  2W5Z A;  2IGQ A;  3M58 A;  3VUZ A;  3CBO A;  4JLG A;  4YPA A;  3DAL A;  3M5A A;  5TEG A;  4QEP A;  3OXG A;  3FPD A;  1N6A A;  5JJ0 A;  4WUY A;  4J7I A;  1XQH A;  3F9Z A;  3QWP A;  3DB5 A;  5F59 A;  2JV0 A;  3TG5 A;  1PEG A;  4FMU A;  5T5G A;  3MO2 A;  3OOI A;  3QWV A;  5LSZ A;  5F5E A;  1MVH A;  3TG4 A;  3MO5 A;  4RZ0 A;  3M53 A;  3PDN A;  5CPR B;  4H12 A;  5CCL A;  3RIB A; 
#chains in the Genus database with same CATH topology
 3S7D A;  4LDG A;  3HNA A;  3OXF A;  4IJD A;  3S7B A;  3SWC A;  1MVX A;  3CBP A;  3M57 A;  3K5K A;  1H3I A;  5ARG A;  1MT6 A;  3S7F A;  3RQ4 A;  3OS5 A;  4C1Q A;  3F9W A;  3OXL A;  5ARF A;  4J8O A;  3MO0 A;  1O9S A;  1N6C A;  5HQ8 A;  4NJ5 A;  3QWW A;  5T0M A;  3RJW A;  5KJK A;  5CCM A;  3OPE A;  5LSX A;  3M59 A;  4AU7 A;  2O8J A;  4E47 A;  3SW9 A;  4MI5 A;  3CBM A;  2BQZ A;  4QEN A;  4YND A;  5JHN A;  1N3J A;  3KMT A;  4MI0 A;  4QEO A;  5F6K C;  5AYF A;  5EG2 A;  4Z4P A;  4I51 A;  3IHX A;  4JDS A;  4IJ8 A;  3N71 A;  3VV0 A;  5T0K A;  2F69 A;  3F9Y A;  5HI7 A;  5KJN A;  3RAY A;  4O30 A;  3BO5 A;  4YPE A;  4YNP A;  2QPW A;  4O6F A;  4YNM A;  4J83 A;  5JIN A;  4YPU A;  2R3A A;  5EX3 A;  5TH7 A;  3RU0 A;  3KMA A;  3S8P A;  2G46 A;  3MEK A;  3EP0 A;  5F6L A;  4J7F A;  1ML9 A;  2W5Y A;  3M54 A;  5TTF A;  1MUF A;  4NVQ A;  4BUP A;  5JIY A;  3M56 A;  3F9X A;  1ZKK A;  5KJM A;  3S7J A;  2RFI A;  5KJL A;  5EX0 A;  3M55 A;  3KMJ A;  2W5Z A;  2IGQ A;  3M58 A;  3VUZ A;  3CBO A;  4JLG A;  4YPA A;  3DAL A;  3M5A A;  5TEG A;  4QEP A;  3OXG A;  3FPD A;  1N6A A;  5JJ0 A;  4WUY A;  4J7I A;  1XQH A;  3F9Z A;  3QWP A;  3DB5 A;  5F59 A;  2JV0 A;  3TG5 A;  1PEG A;  4FMU A;  5T5G A;  3MO2 A;  3OOI A;  3QWV A;  5LSZ A;  5F5E A;  1MVH A;  3TG4 A;  3MO5 A;  4RZ0 A;  3M53 A;  3PDN A;  5CPR B;  4H12 A;  5CCL A;  3RIB A; 
#chains in the Genus database with same CATH homology
 3S7D A;  4LDG A;  3HNA A;  3OXF A;  4IJD A;  3S7B A;  3SWC A;  1MVX A;  3CBP A;  3M57 A;  3K5K A;  1H3I A;  5ARG A;  1MT6 A;  3S7F A;  3RQ4 A;  3OS5 A;  4C1Q A;  3F9W A;  3OXL A;  5ARF A;  4J8O A;  3MO0 A;  1O9S A;  1N6C A;  5HQ8 A;  4NJ5 A;  3QWW A;  5T0M A;  3RJW A;  5KJK A;  5CCM A;  3OPE A;  5LSX A;  3M59 A;  4AU7 A;  2O8J A;  4E47 A;  3SW9 A;  4MI5 A;  3CBM A;  2BQZ A;  4QEN A;  4YND A;  5JHN A;  1N3J A;  3KMT A;  4MI0 A;  4QEO A;  5F6K C;  5AYF A;  5EG2 A;  4Z4P A;  4I51 A;  3IHX A;  4JDS A;  4IJ8 A;  3N71 A;  3VV0 A;  5T0K A;  2F69 A;  3F9Y A;  5HI7 A;  5KJN A;  3RAY A;  4O30 A;  3BO5 A;  4YPE A;  4YNP A;  2QPW A;  4O6F A;  4YNM A;  4J83 A;  5JIN A;  4YPU A;  2R3A A;  5EX3 A;  5TH7 A;  3RU0 A;  3KMA A;  3S8P A;  2G46 A;  3MEK A;  3EP0 A;  5F6L A;  4J7F A;  1ML9 A;  2W5Y A;  3M54 A;  5TTF A;  1MUF A;  4NVQ A;  4BUP A;  5JIY A;  3M56 A;  3F9X A;  1ZKK A;  5KJM A;  3S7J A;  2RFI A;  5KJL A;  5EX0 A;  3M55 A;  3KMJ A;  2W5Z A;  2IGQ A;  3M58 A;  3VUZ A;  3CBO A;  4JLG A;  4YPA A;  3DAL A;  3M5A A;  5TEG A;  4QEP A;  3OXG A;  3FPD A;  1N6A A;  5JJ0 A;  4WUY A;  4J7I A;  1XQH A;  3F9Z A;  3QWP A;  3DB5 A;  5F59 A;  2JV0 A;  3TG5 A;  1PEG A;  4FMU A;  5T5G A;  3MO2 A;  3OOI A;  3QWV A;  5LSZ A;  5F5E A;  1MVH A;  3TG4 A;  3MO5 A;  4RZ0 A;  3M53 A;  3PDN A;  5CPR B;  4H12 A;  5CCL A;  3RIB A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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