1MT6A

Structure of histone h3 k4-specific methyltransferase set7/9 with adohcy
Total Genus 62
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
62
sequence length
280
structure length
280
Chain Sequence
TLEGYYVDDALQGQGVYTYEDGGVLQGTYVDGELNGPAQEYDTDGRLIFKGQYKDNIRHGVCWIYYPDGGSLVGEVNEDGEMTGEKIAYVYPDERTALYGKFIDGEMIEGKLATLMSTEEGRPHFELMPGNSVYHFDKSTSSCISTNALLPDPYESERVYVAESLISSAGEGLFSKVAVGPNTVMSFYNGVRITHQEVDSRDWALNGNTLSLDEETVIDVPEPYNHVSKYCASLGHKANHSFTPNCIYDMFVHPRFGPIKCIRTLRAVEADEELTVAYGY
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords SET9
publication title The active site of the SET domain is constructed on a knot
pubmed rcsb
source organism Homo sapiens
molecule tags Transferase
total genus 62
structure length 280
sequence length 280
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2002-09-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF02493 MORN MORN repeat
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.20.110.10 Mainly Beta Single Sheet Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain 1mt6A01
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 1mt6A02
3MO0A 3OXFA 5F6KC 5ARGA 3S7JA 2W5YA 4IJDA 1MVHA 3DALA 2RFIA 5EX3A 3S8PA 5F59A 3OXLA 5F6LA 3M57A 3S7BA 4WUYA 5T0KA 5KJNA 4J7IA 5LSXA 3VUZA 5F5EA 3VV0A 4BUPA 3RU0A 4YNDA 5ARFA 1N3JA 3CBOA 5HQ8A 4NVQA 3OS5A 4YNPA 5JIYA 3M55A 3KMJA 4YNMA 3RIBA 3RJWA 5JINA 4Z4PA 3F9YA 3S7DA 3MO5A 4MI5A 5KJLA 3K5KA 3F9ZA 3FPDA 5EG2A 5CCLA 3KMTA 3SWCA 3OPEA 4MI0A 3M5AA 4I51A 3HNAA 1ZKKA 2R3AA 3EP0A 3QWPA 3OXGA 2BQZA 1N6AA 5TEGA 4YPEA 1MT6A 4QENA 4O30A 4JLGA 4QEOA 1ML9A 3DB5A 3M59A 2IGQA 5JJ0A 5HI7A 4YPUA 3KMAA 3F9XA 4C1QA 3M56A 3RAYA 3PDNA 5KJMA 3BO5A 4LDGA 5TH7A 5TTFA 3S7FA 5CPRB 3M54A 2QPWA 4FMUA 3RQ4A 3TG5A 1MVXA 2O8JA 4JDSA 1O9SA 5LSZA 4J83A 3N71A 1MUFA 5KJKA 3M53A 4E47A 3SW9A 3MEKA 4H12A 2F69A 5T0MA 4RZ0A 1H3IA 3TG4A 1PEGA 5EX0A 2G46A 3M58A 2JV0A 3QWVA 1XQHA 4QEPA 5CCMA 4IJ8A 5JHNA 2W5ZA 4J7FA 4AU7A 3MO2A 4O6FA 1N6CA 3OOIA 5AYFA 3CBMA 3QWWA 5T5GA 3IHXA 3CBPA 4YPAA 4NJ5A 3F9WA 4J8OA
chains in the Genus database with same CATH superfamily
3MO0A 3OXFA 5F6KC 5ARGA 3S7JA 2W5YA 4IJDA 1MVHA 3DALA 2RFIA 5EX3A 3S8PA 5F59A 3OXLA 5F6LA 3M57A 3S7BA 4WUYA 5T0KA 5KJNA 4J7IA 5LSXA 3VUZA 5F5EA 3VV0A 4BUPA 3RU0A 4YNDA 5ARFA 1N3JA 3CBOA 5HQ8A 4NVQA 3OS5A 4YNPA 5JIYA 3M55A 3KMJA 4YNMA 3RIBA 3RJWA 5JINA 4Z4PA 3F9YA 3S7DA 3MO5A 4MI5A 5KJLA 3K5KA 3F9ZA 3FPDA 5EG2A 5CCLA 3KMTA 3SWCA 3OPEA 4MI0A 3M5AA 4I51A 3HNAA 1ZKKA 2R3AA 3EP0A 3QWPA 3OXGA 2BQZA 1N6AA 5TEGA 4YPEA 1MT6A 4QENA 4O30A 4JLGA 4QEOA 1ML9A 3DB5A 3M59A 2IGQA 5JJ0A 5HI7A 4YPUA 3KMAA 3F9XA 4C1QA 3M56A 3RAYA 3PDNA 5KJMA 3BO5A 4LDGA 5TH7A 5TTFA 3S7FA 5CPRB 3M54A 2QPWA 4FMUA 3RQ4A 3TG5A 1MVXA 2O8JA 4JDSA 1O9SA 5LSZA 4J83A 3N71A 1MUFA 5KJKA 3M53A 4E47A 3SW9A 3MEKA 4H12A 2F69A 5T0MA 4RZ0A 1H3IA 3TG4A 1PEGA 5EX0A 2G46A 3M58A 2JV0A 3QWVA 1XQHA 4QEPA 5CCMA 4IJ8A 5JHNA 2W5ZA 4J7FA 4AU7A 3MO2A 4O6FA 1N6CA 3OOIA 5AYFA 3CBMA 3QWWA 5T5GA 3IHXA 3CBPA 4YPAA 4NJ5A 3F9WA 4J8OA
chains in the Genus database with same CATH topology
3MO0A 3OXFA 5F6KC 5ARGA 3S7JA 2W5YA 4IJDA 1MVHA 3DALA 2RFIA 5EX3A 3S8PA 5F59A 3OXLA 5F6LA 3M57A 3S7BA 4WUYA 5T0KA 5KJNA 4J7IA 5LSXA 3VUZA 5F5EA 3VV0A 4BUPA 3RU0A 4YNDA 5ARFA 1N3JA 3CBOA 5HQ8A 4NVQA 3OS5A 4YNPA 5JIYA 3M55A 3KMJA 4YNMA 3RIBA 3RJWA 5JINA 4Z4PA 3F9YA 3S7DA 3MO5A 4MI5A 5KJLA 3K5KA 3F9ZA 3FPDA 5EG2A 5CCLA 3KMTA 3SWCA 3OPEA 4MI0A 3M5AA 4I51A 3HNAA 1ZKKA 2R3AA 3EP0A 3QWPA 3OXGA 2BQZA 1N6AA 5TEGA 4YPEA 1MT6A 4QENA 4O30A 4JLGA 4QEOA 1ML9A 3DB5A 3M59A 2IGQA 5JJ0A 5HI7A 4YPUA 3KMAA 3F9XA 4C1QA 3M56A 3RAYA 3PDNA 5KJMA 3BO5A 4LDGA 5TH7A 5TTFA 3S7FA 5CPRB 3M54A 2QPWA 4FMUA 3RQ4A 3TG5A 1MVXA 2O8JA 4JDSA 1O9SA 5LSZA 4J83A 3N71A 1MUFA 5KJKA 3M53A 4E47A 3SW9A 3MEKA 4H12A 2F69A 5T0MA 4RZ0A 1H3IA 3TG4A 1PEGA 5EX0A 2G46A 3M58A 2JV0A 3QWVA 1XQHA 4QEPA 5CCMA 4IJ8A 5JHNA 2W5ZA 4J7FA 4AU7A 3MO2A 4O6FA 1N6CA 3OOIA 5AYFA 3CBMA 3QWWA 5T5GA 3IHXA 3CBPA 4YPAA 4NJ5A 3F9WA 4J8OA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3MO0 A;  3OXF A;  5F6K C;  5ARG A;  3S7J A;  2W5Y A;  4IJD A;  1MVH A;  3DAL A;  2RFI A;  5EX3 A;  3S8P A;  5F59 A;  3OXL A;  5F6L A;  3M57 A;  3S7B A;  4WUY A;  5T0K A;  5KJN A;  4J7I A;  5LSX A;  3VUZ A;  5F5E A;  3VV0 A;  4BUP A;  3RU0 A;  4YND A;  5ARF A;  1N3J A;  3CBO A;  5HQ8 A;  4NVQ A;  3OS5 A;  4YNP A;  5JIY A;  3M55 A;  3KMJ A;  4YNM A;  3RIB A;  3RJW A;  5JIN A;  4Z4P A;  3F9Y A;  3S7D A;  3MO5 A;  4MI5 A;  5KJL A;  3K5K A;  3F9Z A;  3FPD A;  5EG2 A;  5CCL A;  3KMT A;  3SWC A;  3OPE A;  4MI0 A;  3M5A A;  4I51 A;  3HNA A;  1ZKK A;  2R3A A;  3EP0 A;  3QWP A;  3OXG A;  2BQZ A;  1N6A A;  5TEG A;  4YPE A;  1MT6 A;  4QEN A;  4O30 A;  4JLG A;  4QEO A;  1ML9 A;  3DB5 A;  3M59 A;  2IGQ A;  5JJ0 A;  5HI7 A;  4YPU A;  3KMA A;  3F9X A;  4C1Q A;  3M56 A;  3RAY A;  3PDN A;  5KJM A;  3BO5 A;  4LDG A;  5TH7 A;  5TTF A;  3S7F A;  5CPR B;  3M54 A;  2QPW A;  4FMU A;  3RQ4 A;  3TG5 A;  1MVX A;  2O8J A;  4JDS A;  1O9S A;  5LSZ A;  4J83 A;  3N71 A;  1MUF A;  5KJK A;  3M53 A;  4E47 A;  3SW9 A;  3MEK A;  4H12 A;  2F69 A;  5T0M A;  4RZ0 A;  1H3I A;  3TG4 A;  1PEG A;  5EX0 A;  2G46 A;  3M58 A;  2JV0 A;  3QWV A;  1XQH A;  4QEP A;  5CCM A;  4IJ8 A;  5JHN A;  2W5Z A;  4J7F A;  4AU7 A;  3MO2 A;  4O6F A;  1N6C A;  3OOI A;  5AYF A;  3CBM A;  3QWW A;  5T5G A;  3IHX A;  3CBP A;  4YPA A;  4NJ5 A;  3F9W A;  4J8O A; 
#chains in the Genus database with same CATH topology
 3MO0 A;  3OXF A;  5F6K C;  5ARG A;  3S7J A;  2W5Y A;  4IJD A;  1MVH A;  3DAL A;  2RFI A;  5EX3 A;  3S8P A;  5F59 A;  3OXL A;  5F6L A;  3M57 A;  3S7B A;  4WUY A;  5T0K A;  5KJN A;  4J7I A;  5LSX A;  3VUZ A;  5F5E A;  3VV0 A;  4BUP A;  3RU0 A;  4YND A;  5ARF A;  1N3J A;  3CBO A;  5HQ8 A;  4NVQ A;  3OS5 A;  4YNP A;  5JIY A;  3M55 A;  3KMJ A;  4YNM A;  3RIB A;  3RJW A;  5JIN A;  4Z4P A;  3F9Y A;  3S7D A;  3MO5 A;  4MI5 A;  5KJL A;  3K5K A;  3F9Z A;  3FPD A;  5EG2 A;  5CCL A;  3KMT A;  3SWC A;  3OPE A;  4MI0 A;  3M5A A;  4I51 A;  3HNA A;  1ZKK A;  2R3A A;  3EP0 A;  3QWP A;  3OXG A;  2BQZ A;  1N6A A;  5TEG A;  4YPE A;  1MT6 A;  4QEN A;  4O30 A;  4JLG A;  4QEO A;  1ML9 A;  3DB5 A;  3M59 A;  2IGQ A;  5JJ0 A;  5HI7 A;  4YPU A;  3KMA A;  3F9X A;  4C1Q A;  3M56 A;  3RAY A;  3PDN A;  5KJM A;  3BO5 A;  4LDG A;  5TH7 A;  5TTF A;  3S7F A;  5CPR B;  3M54 A;  2QPW A;  4FMU A;  3RQ4 A;  3TG5 A;  1MVX A;  2O8J A;  4JDS A;  1O9S A;  5LSZ A;  4J83 A;  3N71 A;  1MUF A;  5KJK A;  3M53 A;  4E47 A;  3SW9 A;  3MEK A;  4H12 A;  2F69 A;  5T0M A;  4RZ0 A;  1H3I A;  3TG4 A;  1PEG A;  5EX0 A;  2G46 A;  3M58 A;  2JV0 A;  3QWV A;  1XQH A;  4QEP A;  5CCM A;  4IJ8 A;  5JHN A;  2W5Z A;  4J7F A;  4AU7 A;  3MO2 A;  4O6F A;  1N6C A;  3OOI A;  5AYF A;  3CBM A;  3QWW A;  5T5G A;  3IHX A;  3CBP A;  4YPA A;  4NJ5 A;  3F9W A;  4J8O A; 
#chains in the Genus database with same CATH homology
 3MO0 A;  3OXF A;  5F6K C;  5ARG A;  3S7J A;  2W5Y A;  4IJD A;  1MVH A;  3DAL A;  2RFI A;  5EX3 A;  3S8P A;  5F59 A;  3OXL A;  5F6L A;  3M57 A;  3S7B A;  4WUY A;  5T0K A;  5KJN A;  4J7I A;  5LSX A;  3VUZ A;  5F5E A;  3VV0 A;  4BUP A;  3RU0 A;  4YND A;  5ARF A;  1N3J A;  3CBO A;  5HQ8 A;  4NVQ A;  3OS5 A;  4YNP A;  5JIY A;  3M55 A;  3KMJ A;  4YNM A;  3RIB A;  3RJW A;  5JIN A;  4Z4P A;  3F9Y A;  3S7D A;  3MO5 A;  4MI5 A;  5KJL A;  3K5K A;  3F9Z A;  3FPD A;  5EG2 A;  5CCL A;  3KMT A;  3SWC A;  3OPE A;  4MI0 A;  3M5A A;  4I51 A;  3HNA A;  1ZKK A;  2R3A A;  3EP0 A;  3QWP A;  3OXG A;  2BQZ A;  1N6A A;  5TEG A;  4YPE A;  1MT6 A;  4QEN A;  4O30 A;  4JLG A;  4QEO A;  1ML9 A;  3DB5 A;  3M59 A;  2IGQ A;  5JJ0 A;  5HI7 A;  4YPU A;  3KMA A;  3F9X A;  4C1Q A;  3M56 A;  3RAY A;  3PDN A;  5KJM A;  3BO5 A;  4LDG A;  5TH7 A;  5TTF A;  3S7F A;  5CPR B;  3M54 A;  2QPW A;  4FMU A;  3RQ4 A;  3TG5 A;  1MVX A;  2O8J A;  4JDS A;  1O9S A;  5LSZ A;  4J83 A;  3N71 A;  1MUF A;  5KJK A;  3M53 A;  4E47 A;  3SW9 A;  3MEK A;  4H12 A;  2F69 A;  5T0M A;  4RZ0 A;  1H3I A;  3TG4 A;  1PEG A;  5EX0 A;  2G46 A;  3M58 A;  2JV0 A;  3QWV A;  1XQH A;  4QEP A;  5CCM A;  4IJ8 A;  5JHN A;  2W5Z A;  4J7F A;  4AU7 A;  3MO2 A;  4O6F A;  1N6C A;  3OOI A;  5AYF A;  3CBM A;  3QWW A;  5T5G A;  3IHX A;  3CBP A;  4YPA A;  4NJ5 A;  3F9W A;  4J8O A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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