3FPDA

G9a-like protein lysine methyltransferase inhibition by bix-01294
Total Genus 61
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
61
sequence length
261
structure length
261
Chain Sequence
VERIVSRDIARGYERIPIPCVNAVDSEPCPSNYKYVSQNCVTSPMNIDRNITHLQYCVCIDDCSSSNCMCGQLSMRCWYDKDGRLLPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLDNKDGEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIKGKLFSCRCGSPKCRHS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Transferase
molecule keywords Histone-lysine N-methyltransferase, H3 lysine-9 specific 5
publication title Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294.
pubmed doi rcsb
source organism Homo sapiens
total genus 61
structure length 261
sequence length 261
chains with identical sequence B
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2009-01-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF05033 Pre-SET Pre-SET motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 3fpdA00
3BO5A 3M58A 3OPEA 3OXGA 5AYFA 1N6CA 4JLGA 1MUFA 1O9SA 3CBMA 2BQZA 3HNAA 4LDGA 5JIYA 5KJNA 4O30A 5CCLA 3S7FA 5T5GA 4QEPA 3MO0A 1MVXA 3IHXA 4YPUA 1ZKKA 4O6FA 4QEOA 5KJKA 4C1QA 3DALA 4J7IA 3M55A 4YNDA 3S7JA 4IJ8A 5TTFA 4E47A 5ARGA 3KMJA 3QWVA 2W5ZA 3M5AA 5CPRB 5HI7A 5EX3A 3MO2A 4YPEA 1ML9A 4IJDA 3RU0A 3OXFA 2F69A 4YNMA 3MO5A 5F6KC 5T0KA 3M56A 3VUZA 3F9XA 5F59A 3CBOA 3TG4A 4AU7A 3OS5A 4H12A 5KJLA 3F9WA 4JDSA 4Z4PA 4I51A 3K5KA 4YPAA 3SWCA 2O8JA 5TEGA 3KMAA 3OXLA 3TG5A 5T0MA 3RAYA 2IGQA 1MT6A 1N6AA 3M53A 2G46A 3F9ZA 1XQHA 2RFIA 3M57A 3FPDA 3QWPA 2JV0A 3F9YA 3S8PA 3MEKA 5KJMA 3DB5A 4J8OA 4QENA 5F6LA 5LSZA 3PDNA 4FMUA 3RJWA 5LSXA 3OOIA 5EG2A 4J7FA 3M59A 4WUYA 3EP0A 1PEGA 4J83A 4MI0A 5JINA 1MVHA 5TH7A 3CBPA 3RQ4A 2QPWA 3SW9A 4NVQA 5JJ0A 4RZ0A 5CCMA 1H3IA 5HQ8A 5JHNA 3RIBA 4MI5A 3QWWA 4NJ5A 5ARFA 1N3JA 4YNPA 5EX0A 2W5YA 3S7BA 3VV0A 3S7DA 3M54A 2R3AA 3N71A 4BUPA 3KMTA 5F5EA
chains in the Genus database with same CATH superfamily
3BO5A 3M58A 3OPEA 3OXGA 5AYFA 1N6CA 4JLGA 1MUFA 1O9SA 3CBMA 2BQZA 3HNAA 4LDGA 5JIYA 5KJNA 4O30A 5CCLA 3S7FA 5T5GA 4QEPA 3MO0A 1MVXA 3IHXA 4YPUA 1ZKKA 4O6FA 4QEOA 5KJKA 4C1QA 3DALA 4J7IA 3M55A 4YNDA 3S7JA 4IJ8A 5TTFA 4E47A 5ARGA 3KMJA 3QWVA 2W5ZA 3M5AA 5CPRB 5HI7A 5EX3A 3MO2A 4YPEA 1ML9A 4IJDA 3RU0A 3OXFA 2F69A 4YNMA 3MO5A 5F6KC 5T0KA 3M56A 3VUZA 3F9XA 5F59A 3CBOA 3TG4A 4AU7A 3OS5A 4H12A 5KJLA 3F9WA 4JDSA 4Z4PA 4I51A 3K5KA 4YPAA 3SWCA 2O8JA 5TEGA 3KMAA 3OXLA 3TG5A 5T0MA 3RAYA 2IGQA 1MT6A 1N6AA 3M53A 2G46A 3F9ZA 1XQHA 2RFIA 3M57A 3FPDA 3QWPA 2JV0A 3F9YA 3S8PA 3MEKA 5KJMA 3DB5A 4J8OA 4QENA 5F6LA 5LSZA 3PDNA 4FMUA 3RJWA 5LSXA 3OOIA 5EG2A 4J7FA 3M59A 4WUYA 3EP0A 1PEGA 4J83A 4MI0A 5JINA 1MVHA 5TH7A 3CBPA 3RQ4A 2QPWA 3SW9A 4NVQA 5JJ0A 4RZ0A 5CCMA 1H3IA 5HQ8A 5JHNA 3RIBA 4MI5A 3QWWA 4NJ5A 5ARFA 1N3JA 4YNPA 5EX0A 2W5YA 3S7BA 3VV0A 3S7DA 3M54A 2R3AA 3N71A 4BUPA 3KMTA 5F5EA
chains in the Genus database with same CATH topology
3BO5A 3M58A 3OPEA 3OXGA 5AYFA 1N6CA 4JLGA 1MUFA 1O9SA 3CBMA 2BQZA 3HNAA 4LDGA 5JIYA 5KJNA 4O30A 5CCLA 3S7FA 5T5GA 4QEPA 3MO0A 1MVXA 3IHXA 4YPUA 1ZKKA 4O6FA 4QEOA 5KJKA 4C1QA 3DALA 4J7IA 3M55A 4YNDA 3S7JA 4IJ8A 5TTFA 4E47A 5ARGA 3KMJA 3QWVA 2W5ZA 3M5AA 5CPRB 5HI7A 5EX3A 3MO2A 4YPEA 1ML9A 4IJDA 3RU0A 3OXFA 2F69A 4YNMA 3MO5A 5F6KC 5T0KA 3M56A 3VUZA 3F9XA 5F59A 3CBOA 3TG4A 4AU7A 3OS5A 4H12A 5KJLA 3F9WA 4JDSA 4Z4PA 4I51A 3K5KA 4YPAA 3SWCA 2O8JA 5TEGA 3KMAA 3OXLA 3TG5A 5T0MA 3RAYA 2IGQA 1MT6A 1N6AA 3M53A 2G46A 3F9ZA 1XQHA 2RFIA 3M57A 3FPDA 3QWPA 2JV0A 3F9YA 3S8PA 3MEKA 5KJMA 3DB5A 4J8OA 4QENA 5F6LA 5LSZA 3PDNA 4FMUA 3RJWA 5LSXA 3OOIA 5EG2A 4J7FA 3M59A 4WUYA 3EP0A 1PEGA 4J83A 4MI0A 5JINA 1MVHA 5TH7A 3CBPA 3RQ4A 2QPWA 3SW9A 4NVQA 5JJ0A 4RZ0A 5CCMA 1H3IA 5HQ8A 5JHNA 3RIBA 4MI5A 3QWWA 4NJ5A 5ARFA 1N3JA 4YNPA 5EX0A 2W5YA 3S7BA 3VV0A 3S7DA 3M54A 2R3AA 3N71A 4BUPA 3KMTA 5F5EA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3BO5 A;  3M58 A;  3OPE A;  3OXG A;  5AYF A;  1N6C A;  4JLG A;  1MUF A;  1O9S A;  3CBM A;  2BQZ A;  3HNA A;  4LDG A;  5JIY A;  5KJN A;  4O30 A;  5CCL A;  3S7F A;  5T5G A;  4QEP A;  3MO0 A;  1MVX A;  3IHX A;  4YPU A;  1ZKK A;  4O6F A;  4QEO A;  5KJK A;  4C1Q A;  3DAL A;  4J7I A;  3M55 A;  4YND A;  3S7J A;  4IJ8 A;  5TTF A;  4E47 A;  5ARG A;  3KMJ A;  3QWV A;  2W5Z A;  3M5A A;  5CPR B;  5HI7 A;  5EX3 A;  3MO2 A;  4YPE A;  1ML9 A;  4IJD A;  3RU0 A;  3OXF A;  2F69 A;  4YNM A;  3MO5 A;  5F6K C;  5T0K A;  3M56 A;  3VUZ A;  3F9X A;  5F59 A;  3CBO A;  3TG4 A;  4AU7 A;  3OS5 A;  4H12 A;  5KJL A;  3F9W A;  4JDS A;  4Z4P A;  4I51 A;  3K5K A;  4YPA A;  3SWC A;  2O8J A;  5TEG A;  3KMA A;  3OXL A;  3TG5 A;  5T0M A;  3RAY A;  2IGQ A;  1MT6 A;  1N6A A;  3M53 A;  2G46 A;  3F9Z A;  1XQH A;  2RFI A;  3M57 A;  3FPD A;  3QWP A;  2JV0 A;  3F9Y A;  3S8P A;  3MEK A;  5KJM A;  3DB5 A;  4J8O A;  4QEN A;  5F6L A;  5LSZ A;  3PDN A;  4FMU A;  3RJW A;  5LSX A;  3OOI A;  5EG2 A;  4J7F A;  3M59 A;  4WUY A;  3EP0 A;  1PEG A;  4J83 A;  4MI0 A;  5JIN A;  1MVH A;  5TH7 A;  3CBP A;  3RQ4 A;  2QPW A;  3SW9 A;  4NVQ A;  5JJ0 A;  4RZ0 A;  5CCM A;  1H3I A;  5HQ8 A;  5JHN A;  3RIB A;  4MI5 A;  3QWW A;  4NJ5 A;  5ARF A;  1N3J A;  4YNP A;  5EX0 A;  2W5Y A;  3S7B A;  3VV0 A;  3S7D A;  3M54 A;  2R3A A;  3N71 A;  4BUP A;  3KMT A;  5F5E A; 
#chains in the Genus database with same CATH topology
 3BO5 A;  3M58 A;  3OPE A;  3OXG A;  5AYF A;  1N6C A;  4JLG A;  1MUF A;  1O9S A;  3CBM A;  2BQZ A;  3HNA A;  4LDG A;  5JIY A;  5KJN A;  4O30 A;  5CCL A;  3S7F A;  5T5G A;  4QEP A;  3MO0 A;  1MVX A;  3IHX A;  4YPU A;  1ZKK A;  4O6F A;  4QEO A;  5KJK A;  4C1Q A;  3DAL A;  4J7I A;  3M55 A;  4YND A;  3S7J A;  4IJ8 A;  5TTF A;  4E47 A;  5ARG A;  3KMJ A;  3QWV A;  2W5Z A;  3M5A A;  5CPR B;  5HI7 A;  5EX3 A;  3MO2 A;  4YPE A;  1ML9 A;  4IJD A;  3RU0 A;  3OXF A;  2F69 A;  4YNM A;  3MO5 A;  5F6K C;  5T0K A;  3M56 A;  3VUZ A;  3F9X A;  5F59 A;  3CBO A;  3TG4 A;  4AU7 A;  3OS5 A;  4H12 A;  5KJL A;  3F9W A;  4JDS A;  4Z4P A;  4I51 A;  3K5K A;  4YPA A;  3SWC A;  2O8J A;  5TEG A;  3KMA A;  3OXL A;  3TG5 A;  5T0M A;  3RAY A;  2IGQ A;  1MT6 A;  1N6A A;  3M53 A;  2G46 A;  3F9Z A;  1XQH A;  2RFI A;  3M57 A;  3FPD A;  3QWP A;  2JV0 A;  3F9Y A;  3S8P A;  3MEK A;  5KJM A;  3DB5 A;  4J8O A;  4QEN A;  5F6L A;  5LSZ A;  3PDN A;  4FMU A;  3RJW A;  5LSX A;  3OOI A;  5EG2 A;  4J7F A;  3M59 A;  4WUY A;  3EP0 A;  1PEG A;  4J83 A;  4MI0 A;  5JIN A;  1MVH A;  5TH7 A;  3CBP A;  3RQ4 A;  2QPW A;  3SW9 A;  4NVQ A;  5JJ0 A;  4RZ0 A;  5CCM A;  1H3I A;  5HQ8 A;  5JHN A;  3RIB A;  4MI5 A;  3QWW A;  4NJ5 A;  5ARF A;  1N3J A;  4YNP A;  5EX0 A;  2W5Y A;  3S7B A;  3VV0 A;  3S7D A;  3M54 A;  2R3A A;  3N71 A;  4BUP A;  3KMT A;  5F5E A; 
#chains in the Genus database with same CATH homology
 3BO5 A;  3M58 A;  3OPE A;  3OXG A;  5AYF A;  1N6C A;  4JLG A;  1MUF A;  1O9S A;  3CBM A;  2BQZ A;  3HNA A;  4LDG A;  5JIY A;  5KJN A;  4O30 A;  5CCL A;  3S7F A;  5T5G A;  4QEP A;  3MO0 A;  1MVX A;  3IHX A;  4YPU A;  1ZKK A;  4O6F A;  4QEO A;  5KJK A;  4C1Q A;  3DAL A;  4J7I A;  3M55 A;  4YND A;  3S7J A;  4IJ8 A;  5TTF A;  4E47 A;  5ARG A;  3KMJ A;  3QWV A;  2W5Z A;  3M5A A;  5CPR B;  5HI7 A;  5EX3 A;  3MO2 A;  4YPE A;  1ML9 A;  4IJD A;  3RU0 A;  3OXF A;  2F69 A;  4YNM A;  3MO5 A;  5F6K C;  5T0K A;  3M56 A;  3VUZ A;  3F9X A;  5F59 A;  3CBO A;  3TG4 A;  4AU7 A;  3OS5 A;  4H12 A;  5KJL A;  3F9W A;  4JDS A;  4Z4P A;  4I51 A;  3K5K A;  4YPA A;  3SWC A;  2O8J A;  5TEG A;  3KMA A;  3OXL A;  3TG5 A;  5T0M A;  3RAY A;  2IGQ A;  1MT6 A;  1N6A A;  3M53 A;  2G46 A;  3F9Z A;  1XQH A;  2RFI A;  3M57 A;  3FPD A;  3QWP A;  2JV0 A;  3F9Y A;  3S8P A;  3MEK A;  5KJM A;  3DB5 A;  4J8O A;  4QEN A;  5F6L A;  5LSZ A;  3PDN A;  4FMU A;  3RJW A;  5LSX A;  3OOI A;  5EG2 A;  4J7F A;  3M59 A;  4WUY A;  3EP0 A;  1PEG A;  4J83 A;  4MI0 A;  5JIN A;  1MVH A;  5TH7 A;  3CBP A;  3RQ4 A;  2QPW A;  3SW9 A;  4NVQ A;  5JJ0 A;  4RZ0 A;  5CCM A;  1H3I A;  5HQ8 A;  5JHN A;  3RIB A;  4MI5 A;  3QWW A;  4NJ5 A;  5ARF A;  1N3J A;  4YNP A;  5EX0 A;  2W5Y A;  3S7B A;  3VV0 A;  3S7D A;  3M54 A;  2R3A A;  3N71 A;  4BUP A;  3KMT A;  5F5E A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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