3FPDA

G9a-like protein lysine methyltransferase inhibition by bix-01294
Total Genus 61
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
61
sequence length
261
structure length
261
Chain Sequence
VERIVSRDIARGYERIPIPCVNAVDSEPCPSNYKYVSQNCVTSPMNIDRNITHLQYCVCIDDCSSSNCMCGQLSMRCWYDKDGRLLPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLDNKDGEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIKGKLFSCRCGSPKCRHS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Histone-lysine N-methyltransferase, H3 lysine-9 specific 5
publication title Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Transferase
total genus 61
structure length 261
sequence length 261
chains with identical sequence B
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2009-01-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF05033 Pre-SET Pre-SET motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 3fpdA00
3DB5A 3M57A 3OXFA 4MI5A 5ARFA 4E47A 5T5GA 1MT6A 3QWPA 5LSZA 3OXGA 4LDGA 3M55A 5EX0A 1MUFA 3MEKA 2RFIA 1MVXA 5F5EA 4YNDA 4QEPA 3S7DA 3S7FA 3M54A 4NVQA 4YNPA 3M53A 3RU0A 3SWCA 3RQ4A 3OXLA 3MO5A 5KJNA 4FMUA 5JINA 5LSXA 5KJKA 5F59A 1ZKKA 2G46A 4J8OA 3PDNA 1MVHA 5CCMA 4YPAA 4YPUA 3F9ZA 3RJWA 4QEOA 4O6FA 1O9SA 3KMJA 3QWWA 1N6AA 4AU7A 3MO0A 4YNMA 1ML9A 3S8PA 5TTFA 3M58A 4J7IA 2W5ZA 3HNAA 5HQ8A 3K5KA 5ARGA 3S7BA 3CBMA 3OOIA 3DALA 5HI7A 4Z4PA 1N6CA 3CBPA 2F69A 5T0MA 3F9WA 5CCLA 2IGQA 5CPRB 4BUPA 5TH7A 4JLGA 3QWVA 3M5AA 4I51A 3EP0A 4J83A 4J7FA 3TG5A 3VUZA 3S7JA 5KJLA 4NJ5A 4WUYA 4MI0A 1H3IA 5JIYA 5EX3A 2JV0A 2O8JA 5KJMA 3RIBA 3KMTA 1N3JA 4RZ0A 2R3AA 3F9YA 4IJDA 3M56A 4O30A 3RAYA 4QENA 5T0KA 1PEGA 3VV0A 3SW9A 3N71A 3TG4A 2W5YA 3OS5A 2QPWA 5F6LA 4JDSA 1XQHA 3M59A 3IHXA 3OPEA 3KMAA 3CBOA 3BO5A 5F6KC 5TEGA 4IJ8A 3FPDA 5AYFA 4H12A 5JHNA 3F9XA 2BQZA 4C1QA 5JJ0A 3MO2A 5EG2A 4YPEA
chains in the Genus database with same CATH superfamily
3DB5A 3M57A 3OXFA 4MI5A 5ARFA 4E47A 5T5GA 1MT6A 3QWPA 5LSZA 3OXGA 4LDGA 3M55A 5EX0A 1MUFA 3MEKA 2RFIA 1MVXA 5F5EA 4YNDA 4QEPA 3S7DA 3S7FA 3M54A 4NVQA 4YNPA 3M53A 3RU0A 3SWCA 3RQ4A 3OXLA 3MO5A 5KJNA 4FMUA 5JINA 5LSXA 5KJKA 5F59A 1ZKKA 2G46A 4J8OA 3PDNA 1MVHA 5CCMA 4YPAA 4YPUA 3F9ZA 3RJWA 4QEOA 4O6FA 1O9SA 3KMJA 3QWWA 1N6AA 4AU7A 3MO0A 4YNMA 1ML9A 3S8PA 5TTFA 3M58A 4J7IA 2W5ZA 3HNAA 5HQ8A 3K5KA 5ARGA 3S7BA 3CBMA 3OOIA 3DALA 5HI7A 4Z4PA 1N6CA 3CBPA 2F69A 5T0MA 3F9WA 5CCLA 2IGQA 5CPRB 4BUPA 5TH7A 4JLGA 3QWVA 3M5AA 4I51A 3EP0A 4J83A 4J7FA 3TG5A 3VUZA 3S7JA 5KJLA 4NJ5A 4WUYA 4MI0A 1H3IA 5JIYA 5EX3A 2JV0A 2O8JA 5KJMA 3RIBA 3KMTA 1N3JA 4RZ0A 2R3AA 3F9YA 4IJDA 3M56A 4O30A 3RAYA 4QENA 5T0KA 1PEGA 3VV0A 3SW9A 3N71A 3TG4A 2W5YA 3OS5A 2QPWA 5F6LA 4JDSA 1XQHA 3M59A 3IHXA 3OPEA 3KMAA 3CBOA 3BO5A 5F6KC 5TEGA 4IJ8A 3FPDA 5AYFA 4H12A 5JHNA 3F9XA 2BQZA 4C1QA 5JJ0A 3MO2A 5EG2A 4YPEA
chains in the Genus database with same CATH topology
3DB5A 3M57A 3OXFA 4MI5A 5ARFA 4E47A 5T5GA 1MT6A 3QWPA 5LSZA 3OXGA 4LDGA 3M55A 5EX0A 1MUFA 3MEKA 2RFIA 1MVXA 5F5EA 4YNDA 4QEPA 3S7DA 3S7FA 3M54A 4NVQA 4YNPA 3M53A 3RU0A 3SWCA 3RQ4A 3OXLA 3MO5A 5KJNA 4FMUA 5JINA 5LSXA 5KJKA 5F59A 1ZKKA 2G46A 4J8OA 3PDNA 1MVHA 5CCMA 4YPAA 4YPUA 3F9ZA 3RJWA 4QEOA 4O6FA 1O9SA 3KMJA 3QWWA 1N6AA 4AU7A 3MO0A 4YNMA 1ML9A 3S8PA 5TTFA 3M58A 4J7IA 2W5ZA 3HNAA 5HQ8A 3K5KA 5ARGA 3S7BA 3CBMA 3OOIA 3DALA 5HI7A 4Z4PA 1N6CA 3CBPA 2F69A 5T0MA 3F9WA 5CCLA 2IGQA 5CPRB 4BUPA 5TH7A 4JLGA 3QWVA 3M5AA 4I51A 3EP0A 4J83A 4J7FA 3TG5A 3VUZA 3S7JA 5KJLA 4NJ5A 4WUYA 4MI0A 1H3IA 5JIYA 5EX3A 2JV0A 2O8JA 5KJMA 3RIBA 3KMTA 1N3JA 4RZ0A 2R3AA 3F9YA 4IJDA 3M56A 4O30A 3RAYA 4QENA 5T0KA 1PEGA 3VV0A 3SW9A 3N71A 3TG4A 2W5YA 3OS5A 2QPWA 5F6LA 4JDSA 1XQHA 3M59A 3IHXA 3OPEA 3KMAA 3CBOA 3BO5A 5F6KC 5TEGA 4IJ8A 3FPDA 5AYFA 4H12A 5JHNA 3F9XA 2BQZA 4C1QA 5JJ0A 3MO2A 5EG2A 4YPEA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3DB5 A;  3M57 A;  3OXF A;  4MI5 A;  5ARF A;  4E47 A;  5T5G A;  1MT6 A;  3QWP A;  5LSZ A;  3OXG A;  4LDG A;  3M55 A;  5EX0 A;  1MUF A;  3MEK A;  2RFI A;  1MVX A;  5F5E A;  4YND A;  4QEP A;  3S7D A;  3S7F A;  3M54 A;  4NVQ A;  4YNP A;  3M53 A;  3RU0 A;  3SWC A;  3RQ4 A;  3OXL A;  3MO5 A;  5KJN A;  4FMU A;  5JIN A;  5LSX A;  5KJK A;  5F59 A;  1ZKK A;  2G46 A;  4J8O A;  3PDN A;  1MVH A;  5CCM A;  4YPA A;  4YPU A;  3F9Z A;  3RJW A;  4QEO A;  4O6F A;  1O9S A;  3KMJ A;  3QWW A;  1N6A A;  4AU7 A;  3MO0 A;  4YNM A;  1ML9 A;  3S8P A;  5TTF A;  3M58 A;  4J7I A;  2W5Z A;  3HNA A;  5HQ8 A;  3K5K A;  5ARG A;  3S7B A;  3CBM A;  3OOI A;  3DAL A;  5HI7 A;  4Z4P A;  1N6C A;  3CBP A;  2F69 A;  5T0M A;  3F9W A;  5CCL A;  2IGQ A;  5CPR B;  4BUP A;  5TH7 A;  4JLG A;  3QWV A;  3M5A A;  4I51 A;  3EP0 A;  4J83 A;  4J7F A;  3TG5 A;  3VUZ A;  3S7J A;  5KJL A;  4NJ5 A;  4WUY A;  4MI0 A;  1H3I A;  5JIY A;  5EX3 A;  2JV0 A;  2O8J A;  5KJM A;  3RIB A;  3KMT A;  1N3J A;  4RZ0 A;  2R3A A;  3F9Y A;  4IJD A;  3M56 A;  4O30 A;  3RAY A;  4QEN A;  5T0K A;  1PEG A;  3VV0 A;  3SW9 A;  3N71 A;  3TG4 A;  2W5Y A;  3OS5 A;  2QPW A;  5F6L A;  4JDS A;  1XQH A;  3M59 A;  3IHX A;  3OPE A;  3KMA A;  3CBO A;  3BO5 A;  5F6K C;  5TEG A;  4IJ8 A;  3FPD A;  5AYF A;  4H12 A;  5JHN A;  3F9X A;  2BQZ A;  4C1Q A;  5JJ0 A;  3MO2 A;  5EG2 A;  4YPE A; 
#chains in the Genus database with same CATH topology
 3DB5 A;  3M57 A;  3OXF A;  4MI5 A;  5ARF A;  4E47 A;  5T5G A;  1MT6 A;  3QWP A;  5LSZ A;  3OXG A;  4LDG A;  3M55 A;  5EX0 A;  1MUF A;  3MEK A;  2RFI A;  1MVX A;  5F5E A;  4YND A;  4QEP A;  3S7D A;  3S7F A;  3M54 A;  4NVQ A;  4YNP A;  3M53 A;  3RU0 A;  3SWC A;  3RQ4 A;  3OXL A;  3MO5 A;  5KJN A;  4FMU A;  5JIN A;  5LSX A;  5KJK A;  5F59 A;  1ZKK A;  2G46 A;  4J8O A;  3PDN A;  1MVH A;  5CCM A;  4YPA A;  4YPU A;  3F9Z A;  3RJW A;  4QEO A;  4O6F A;  1O9S A;  3KMJ A;  3QWW A;  1N6A A;  4AU7 A;  3MO0 A;  4YNM A;  1ML9 A;  3S8P A;  5TTF A;  3M58 A;  4J7I A;  2W5Z A;  3HNA A;  5HQ8 A;  3K5K A;  5ARG A;  3S7B A;  3CBM A;  3OOI A;  3DAL A;  5HI7 A;  4Z4P A;  1N6C A;  3CBP A;  2F69 A;  5T0M A;  3F9W A;  5CCL A;  2IGQ A;  5CPR B;  4BUP A;  5TH7 A;  4JLG A;  3QWV A;  3M5A A;  4I51 A;  3EP0 A;  4J83 A;  4J7F A;  3TG5 A;  3VUZ A;  3S7J A;  5KJL A;  4NJ5 A;  4WUY A;  4MI0 A;  1H3I A;  5JIY A;  5EX3 A;  2JV0 A;  2O8J A;  5KJM A;  3RIB A;  3KMT A;  1N3J A;  4RZ0 A;  2R3A A;  3F9Y A;  4IJD A;  3M56 A;  4O30 A;  3RAY A;  4QEN A;  5T0K A;  1PEG A;  3VV0 A;  3SW9 A;  3N71 A;  3TG4 A;  2W5Y A;  3OS5 A;  2QPW A;  5F6L A;  4JDS A;  1XQH A;  3M59 A;  3IHX A;  3OPE A;  3KMA A;  3CBO A;  3BO5 A;  5F6K C;  5TEG A;  4IJ8 A;  3FPD A;  5AYF A;  4H12 A;  5JHN A;  3F9X A;  2BQZ A;  4C1Q A;  5JJ0 A;  3MO2 A;  5EG2 A;  4YPE A; 
#chains in the Genus database with same CATH homology
 3DB5 A;  3M57 A;  3OXF A;  4MI5 A;  5ARF A;  4E47 A;  5T5G A;  1MT6 A;  3QWP A;  5LSZ A;  3OXG A;  4LDG A;  3M55 A;  5EX0 A;  1MUF A;  3MEK A;  2RFI A;  1MVX A;  5F5E A;  4YND A;  4QEP A;  3S7D A;  3S7F A;  3M54 A;  4NVQ A;  4YNP A;  3M53 A;  3RU0 A;  3SWC A;  3RQ4 A;  3OXL A;  3MO5 A;  5KJN A;  4FMU A;  5JIN A;  5LSX A;  5KJK A;  5F59 A;  1ZKK A;  2G46 A;  4J8O A;  3PDN A;  1MVH A;  5CCM A;  4YPA A;  4YPU A;  3F9Z A;  3RJW A;  4QEO A;  4O6F A;  1O9S A;  3KMJ A;  3QWW A;  1N6A A;  4AU7 A;  3MO0 A;  4YNM A;  1ML9 A;  3S8P A;  5TTF A;  3M58 A;  4J7I A;  2W5Z A;  3HNA A;  5HQ8 A;  3K5K A;  5ARG A;  3S7B A;  3CBM A;  3OOI A;  3DAL A;  5HI7 A;  4Z4P A;  1N6C A;  3CBP A;  2F69 A;  5T0M A;  3F9W A;  5CCL A;  2IGQ A;  5CPR B;  4BUP A;  5TH7 A;  4JLG A;  3QWV A;  3M5A A;  4I51 A;  3EP0 A;  4J83 A;  4J7F A;  3TG5 A;  3VUZ A;  3S7J A;  5KJL A;  4NJ5 A;  4WUY A;  4MI0 A;  1H3I A;  5JIY A;  5EX3 A;  2JV0 A;  2O8J A;  5KJM A;  3RIB A;  3KMT A;  1N3J A;  4RZ0 A;  2R3A A;  3F9Y A;  4IJD A;  3M56 A;  4O30 A;  3RAY A;  4QEN A;  5T0K A;  1PEG A;  3VV0 A;  3SW9 A;  3N71 A;  3TG4 A;  2W5Y A;  3OS5 A;  2QPW A;  5F6L A;  4JDS A;  1XQH A;  3M59 A;  3IHX A;  3OPE A;  3KMA A;  3CBO A;  3BO5 A;  5F6K C;  5TEG A;  4IJ8 A;  3FPD A;  5AYF A;  4H12 A;  5JHN A;  3F9X A;  2BQZ A;  4C1Q A;  5JJ0 A;  3MO2 A;  5EG2 A;  4YPE A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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