3FPDA

G9a-like protein lysine methyltransferase inhibition by bix-01294
Total Genus 61
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
61
sequence length
261
structure length
261
Chain Sequence
VERIVSRDIARGYERIPIPCVNAVDSEPCPSNYKYVSQNCVTSPMNIDRNITHLQYCVCIDDCSSSNCMCGQLSMRCWYDKDGRLLPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLDNKDGEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIKGKLFSCRCGSPKCRHS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Transferase
molecule keywords Histone-lysine N-methyltransferase, H3 lysine-9 specific 5
total genus 61
structure length 261
sequence length 261
chains with identical sequence B
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2009-01-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF05033 Pre-SET Pre-SET motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 3fpdA00
3RIBA 3M56A 1H3IA 3RU0A 3KMJA 3RQ4A 1N6AA 5EG2A 3F9ZA 3FPDA 3N71A 5T5GA 4WUYA 5JHNA 5F59A 4I51A 3S7BA 2G46A 4Z4PA 3M53A 3K5KA 5KJLA 3S7DA 1MVHA 1MVXA 4LDGA 4BUPA 3CBPA 5KJMA 5CCLA 4AU7A 3KMTA 5CPRB 3IHXA 2BQZA 4JDSA 5F6LA 3SW9A 1MT6A 2F69A 4MI0A 2O8JA 3MO0A 4YPEA 3M54A 5HI7A 3M59A 4FMUA 5KJKA 3HNAA 2QPWA 4J7IA 5T0KA 3OXLA 5T0MA 3OPEA 4MI5A 4YNPA 3BO5A 2JV0A 1O9SA 5F5EA 3SWCA 5KJNA 4QEPA 4QENA 3M55A 3M5AA 5AYFA 3MO5A 5JIYA 5F6KC 5LSZA 1N6CA 3OOIA 1ZKKA 4O6FA 3M58A 4RZ0A 1XQHA 3QWWA 3S8PA 3KMAA 3CBOA 3RAYA 2IGQA 3RJWA 4NVQA 4C1QA 3EP0A 5ARFA 3MO2A 3QWPA 4H12A 3OXFA 3M57A 5ARGA 3S7JA 3CBMA 4E47A 5LSXA 4YPUA 5TTFA 4J8OA 4JLGA 3TG4A 3F9XA 3F9WA 4NJ5A 5HQ8A 3MEKA 4IJ8A 3OS5A 4QEOA 4O30A 4J83A 4YNDA 4YPAA 3OXGA 1MUFA 3S7FA 4J7FA 2W5ZA 3TG5A 3VV0A 4IJDA 4YNMA 2R3AA 5EX3A 2W5YA 3DALA 5JINA 1PEGA 5TEGA 1ML9A 1N3JA 3DB5A 3PDNA 5EX0A 5JJ0A 5TH7A 2RFIA 3QWVA 3VUZA 5CCMA 3F9YA
chains in the Genus database with same CATH superfamily
3RIBA 3M56A 1H3IA 3RU0A 3KMJA 3RQ4A 1N6AA 5EG2A 3F9ZA 3FPDA 3N71A 5T5GA 4WUYA 5JHNA 5F59A 4I51A 3S7BA 2G46A 4Z4PA 3M53A 3K5KA 5KJLA 3S7DA 1MVHA 1MVXA 4LDGA 4BUPA 3CBPA 5KJMA 5CCLA 4AU7A 3KMTA 5CPRB 3IHXA 2BQZA 4JDSA 5F6LA 3SW9A 1MT6A 2F69A 4MI0A 2O8JA 3MO0A 4YPEA 3M54A 5HI7A 3M59A 4FMUA 5KJKA 3HNAA 2QPWA 4J7IA 5T0KA 3OXLA 5T0MA 3OPEA 4MI5A 4YNPA 3BO5A 2JV0A 1O9SA 5F5EA 3SWCA 5KJNA 4QEPA 4QENA 3M55A 3M5AA 5AYFA 3MO5A 5JIYA 5F6KC 5LSZA 1N6CA 3OOIA 1ZKKA 4O6FA 3M58A 4RZ0A 1XQHA 3QWWA 3S8PA 3KMAA 3CBOA 3RAYA 2IGQA 3RJWA 4NVQA 4C1QA 3EP0A 5ARFA 3MO2A 3QWPA 4H12A 3OXFA 3M57A 5ARGA 3S7JA 3CBMA 4E47A 5LSXA 4YPUA 5TTFA 4J8OA 4JLGA 3TG4A 3F9XA 3F9WA 4NJ5A 5HQ8A 3MEKA 4IJ8A 3OS5A 4QEOA 4O30A 4J83A 4YNDA 4YPAA 3OXGA 1MUFA 3S7FA 4J7FA 2W5ZA 3TG5A 3VV0A 4IJDA 4YNMA 2R3AA 5EX3A 2W5YA 3DALA 5JINA 1PEGA 5TEGA 1ML9A 1N3JA 3DB5A 3PDNA 5EX0A 5JJ0A 5TH7A 2RFIA 3QWVA 3VUZA 5CCMA 3F9YA
chains in the Genus database with same CATH topology
3RIBA 3M56A 1H3IA 3RU0A 3KMJA 3RQ4A 1N6AA 5EG2A 3F9ZA 3FPDA 3N71A 5T5GA 4WUYA 5JHNA 5F59A 4I51A 3S7BA 2G46A 4Z4PA 3M53A 3K5KA 5KJLA 3S7DA 1MVHA 1MVXA 4LDGA 4BUPA 3CBPA 5KJMA 5CCLA 4AU7A 3KMTA 5CPRB 3IHXA 2BQZA 4JDSA 5F6LA 3SW9A 1MT6A 2F69A 4MI0A 2O8JA 3MO0A 4YPEA 3M54A 5HI7A 3M59A 4FMUA 5KJKA 3HNAA 2QPWA 4J7IA 5T0KA 3OXLA 5T0MA 3OPEA 4MI5A 4YNPA 3BO5A 2JV0A 1O9SA 5F5EA 3SWCA 5KJNA 4QEPA 4QENA 3M55A 3M5AA 5AYFA 3MO5A 5JIYA 5F6KC 5LSZA 1N6CA 3OOIA 1ZKKA 4O6FA 3M58A 4RZ0A 1XQHA 3QWWA 3S8PA 3KMAA 3CBOA 3RAYA 2IGQA 3RJWA 4NVQA 4C1QA 3EP0A 5ARFA 3MO2A 3QWPA 4H12A 3OXFA 3M57A 5ARGA 3S7JA 3CBMA 4E47A 5LSXA 4YPUA 5TTFA 4J8OA 4JLGA 3TG4A 3F9XA 3F9WA 4NJ5A 5HQ8A 3MEKA 4IJ8A 3OS5A 4QEOA 4O30A 4J83A 4YNDA 4YPAA 3OXGA 1MUFA 3S7FA 4J7FA 2W5ZA 3TG5A 3VV0A 4IJDA 4YNMA 2R3AA 5EX3A 2W5YA 3DALA 5JINA 1PEGA 5TEGA 1ML9A 1N3JA 3DB5A 3PDNA 5EX0A 5JJ0A 5TH7A 2RFIA 3QWVA 3VUZA 5CCMA 3F9YA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3RIB A;  3M56 A;  1H3I A;  3RU0 A;  3KMJ A;  3RQ4 A;  1N6A A;  5EG2 A;  3F9Z A;  3FPD A;  3N71 A;  5T5G A;  4WUY A;  5JHN A;  5F59 A;  4I51 A;  3S7B A;  2G46 A;  4Z4P A;  3M53 A;  3K5K A;  5KJL A;  3S7D A;  1MVH A;  1MVX A;  4LDG A;  4BUP A;  3CBP A;  5KJM A;  5CCL A;  4AU7 A;  3KMT A;  5CPR B;  3IHX A;  2BQZ A;  4JDS A;  5F6L A;  3SW9 A;  1MT6 A;  2F69 A;  4MI0 A;  2O8J A;  3MO0 A;  4YPE A;  3M54 A;  5HI7 A;  3M59 A;  4FMU A;  5KJK A;  3HNA A;  2QPW A;  4J7I A;  5T0K A;  3OXL A;  5T0M A;  3OPE A;  4MI5 A;  4YNP A;  3BO5 A;  2JV0 A;  1O9S A;  5F5E A;  3SWC A;  5KJN A;  4QEP A;  4QEN A;  3M55 A;  3M5A A;  5AYF A;  3MO5 A;  5JIY A;  5F6K C;  5LSZ A;  1N6C A;  3OOI A;  1ZKK A;  4O6F A;  3M58 A;  4RZ0 A;  1XQH A;  3QWW A;  3S8P A;  3KMA A;  3CBO A;  3RAY A;  2IGQ A;  3RJW A;  4NVQ A;  4C1Q A;  3EP0 A;  5ARF A;  3MO2 A;  3QWP A;  4H12 A;  3OXF A;  3M57 A;  5ARG A;  3S7J A;  3CBM A;  4E47 A;  5LSX A;  4YPU A;  5TTF A;  4J8O A;  4JLG A;  3TG4 A;  3F9X A;  3F9W A;  4NJ5 A;  5HQ8 A;  3MEK A;  4IJ8 A;  3OS5 A;  4QEO A;  4O30 A;  4J83 A;  4YND A;  4YPA A;  3OXG A;  1MUF A;  3S7F A;  4J7F A;  2W5Z A;  3TG5 A;  3VV0 A;  4IJD A;  4YNM A;  2R3A A;  5EX3 A;  2W5Y A;  3DAL A;  5JIN A;  1PEG A;  5TEG A;  1ML9 A;  1N3J A;  3DB5 A;  3PDN A;  5EX0 A;  5JJ0 A;  5TH7 A;  2RFI A;  3QWV A;  3VUZ A;  5CCM A;  3F9Y A; 
#chains in the Genus database with same CATH topology
 3RIB A;  3M56 A;  1H3I A;  3RU0 A;  3KMJ A;  3RQ4 A;  1N6A A;  5EG2 A;  3F9Z A;  3FPD A;  3N71 A;  5T5G A;  4WUY A;  5JHN A;  5F59 A;  4I51 A;  3S7B A;  2G46 A;  4Z4P A;  3M53 A;  3K5K A;  5KJL A;  3S7D A;  1MVH A;  1MVX A;  4LDG A;  4BUP A;  3CBP A;  5KJM A;  5CCL A;  4AU7 A;  3KMT A;  5CPR B;  3IHX A;  2BQZ A;  4JDS A;  5F6L A;  3SW9 A;  1MT6 A;  2F69 A;  4MI0 A;  2O8J A;  3MO0 A;  4YPE A;  3M54 A;  5HI7 A;  3M59 A;  4FMU A;  5KJK A;  3HNA A;  2QPW A;  4J7I A;  5T0K A;  3OXL A;  5T0M A;  3OPE A;  4MI5 A;  4YNP A;  3BO5 A;  2JV0 A;  1O9S A;  5F5E A;  3SWC A;  5KJN A;  4QEP A;  4QEN A;  3M55 A;  3M5A A;  5AYF A;  3MO5 A;  5JIY A;  5F6K C;  5LSZ A;  1N6C A;  3OOI A;  1ZKK A;  4O6F A;  3M58 A;  4RZ0 A;  1XQH A;  3QWW A;  3S8P A;  3KMA A;  3CBO A;  3RAY A;  2IGQ A;  3RJW A;  4NVQ A;  4C1Q A;  3EP0 A;  5ARF A;  3MO2 A;  3QWP A;  4H12 A;  3OXF A;  3M57 A;  5ARG A;  3S7J A;  3CBM A;  4E47 A;  5LSX A;  4YPU A;  5TTF A;  4J8O A;  4JLG A;  3TG4 A;  3F9X A;  3F9W A;  4NJ5 A;  5HQ8 A;  3MEK A;  4IJ8 A;  3OS5 A;  4QEO A;  4O30 A;  4J83 A;  4YND A;  4YPA A;  3OXG A;  1MUF A;  3S7F A;  4J7F A;  2W5Z A;  3TG5 A;  3VV0 A;  4IJD A;  4YNM A;  2R3A A;  5EX3 A;  2W5Y A;  3DAL A;  5JIN A;  1PEG A;  5TEG A;  1ML9 A;  1N3J A;  3DB5 A;  3PDN A;  5EX0 A;  5JJ0 A;  5TH7 A;  2RFI A;  3QWV A;  3VUZ A;  5CCM A;  3F9Y A; 
#chains in the Genus database with same CATH homology
 3RIB A;  3M56 A;  1H3I A;  3RU0 A;  3KMJ A;  3RQ4 A;  1N6A A;  5EG2 A;  3F9Z A;  3FPD A;  3N71 A;  5T5G A;  4WUY A;  5JHN A;  5F59 A;  4I51 A;  3S7B A;  2G46 A;  4Z4P A;  3M53 A;  3K5K A;  5KJL A;  3S7D A;  1MVH A;  1MVX A;  4LDG A;  4BUP A;  3CBP A;  5KJM A;  5CCL A;  4AU7 A;  3KMT A;  5CPR B;  3IHX A;  2BQZ A;  4JDS A;  5F6L A;  3SW9 A;  1MT6 A;  2F69 A;  4MI0 A;  2O8J A;  3MO0 A;  4YPE A;  3M54 A;  5HI7 A;  3M59 A;  4FMU A;  5KJK A;  3HNA A;  2QPW A;  4J7I A;  5T0K A;  3OXL A;  5T0M A;  3OPE A;  4MI5 A;  4YNP A;  3BO5 A;  2JV0 A;  1O9S A;  5F5E A;  3SWC A;  5KJN A;  4QEP A;  4QEN A;  3M55 A;  3M5A A;  5AYF A;  3MO5 A;  5JIY A;  5F6K C;  5LSZ A;  1N6C A;  3OOI A;  1ZKK A;  4O6F A;  3M58 A;  4RZ0 A;  1XQH A;  3QWW A;  3S8P A;  3KMA A;  3CBO A;  3RAY A;  2IGQ A;  3RJW A;  4NVQ A;  4C1Q A;  3EP0 A;  5ARF A;  3MO2 A;  3QWP A;  4H12 A;  3OXF A;  3M57 A;  5ARG A;  3S7J A;  3CBM A;  4E47 A;  5LSX A;  4YPU A;  5TTF A;  4J8O A;  4JLG A;  3TG4 A;  3F9X A;  3F9W A;  4NJ5 A;  5HQ8 A;  3MEK A;  4IJ8 A;  3OS5 A;  4QEO A;  4O30 A;  4J83 A;  4YND A;  4YPA A;  3OXG A;  1MUF A;  3S7F A;  4J7F A;  2W5Z A;  3TG5 A;  3VV0 A;  4IJD A;  4YNM A;  2R3A A;  5EX3 A;  2W5Y A;  3DAL A;  5JIN A;  1PEG A;  5TEG A;  1ML9 A;  1N3J A;  3DB5 A;  3PDN A;  5EX0 A;  5JJ0 A;  5TH7 A;  2RFI A;  3QWV A;  3VUZ A;  5CCM A;  3F9Y A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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