3FPDA

G9a-like protein lysine methyltransferase inhibition by bix-01294
Total Genus 61
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
61
sequence length
261
structure length
261
Chain Sequence
VERIVSRDIARGYERIPIPCVNAVDSEPCPSNYKYVSQNCVTSPMNIDRNITHLQYCVCIDDCSSSNCMCGQLSMRCWYDKDGRLLPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLDNKDGEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIKGKLFSCRCGSPKCRHS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Transferase
molecule keywords Histone-lysine N-methyltransferase, H3 lysine-9 specific 5
total genus 61
structure length 261
sequence length 261
chains with identical sequence B
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2009-01-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF05033 Pre-SET Pre-SET motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 3fpdA00
3BO5A 1MUFA 4JDSA 3MO5A 4YPUA 4WUYA 4YNDA 3F9YA 3M58A 3OXGA 3M56A 5T5GA 3RU0A 3KMTA 4LDGA 5T0MA 5LSXA 4O30A 3OXFA 3CBMA 5CCMA 1XQHA 4I51A 3TG4A 5F5EA 1ML9A 4QEPA 3RIBA 5EX3A 5TEGA 4JLGA 3S7FA 3M54A 5T0KA 1O9SA 3CBPA 3RQ4A 3OS5A 4YPEA 3F9XA 5F6KC 4NVQA 4QENA 5AYFA 5KJLA 1PEGA 3K5KA 3MO2A 4J7IA 5KJMA 1ZKKA 5TTFA 2QPWA 1N6CA 3QWWA 3OPEA 3S7BA 3F9WA 3M5AA 5HQ8A 2BQZA 2R3AA 3OXLA 1MT6A 4J83A 4MI0A 3S7JA 4IJ8A 5JIYA 3RAYA 1N6AA 3PDNA 3M55A 3QWPA 2W5YA 3M59A 2O8JA 2F69A 3HNAA 4O6FA 3OOIA 2RFIA 3DB5A 5TH7A 4QEOA 1H3IA 3VV0A 4IJDA 3KMJA 4YNPA 5JJ0A 2W5ZA 5EX0A 3S8PA 3IHXA 4NJ5A 3RJWA 5ARFA 3M57A 1N3JA 3S7DA 5LSZA 2G46A 4BUPA 3N71A 5HI7A 4AU7A 4Z4PA 4J7FA 3SW9A 5ARGA 2IGQA 3SWCA 5EG2A 4J8OA 3EP0A 4E47A 3KMAA 3QWVA 4H12A 5CPRB 4RZ0A 1MVXA 3CBOA 5JINA 4MI5A 5KJNA 3MEKA 5F59A 5CCLA 4YNMA 3TG5A 4C1QA 2JV0A 3DALA 3F9ZA 3MO0A 4YPAA 5F6LA 4FMUA 5KJKA 5JHNA 1MVHA 3FPDA 3VUZA 3M53A
chains in the Genus database with same CATH superfamily
3BO5A 1MUFA 4JDSA 3MO5A 4YPUA 4WUYA 4YNDA 3F9YA 3M58A 3OXGA 3M56A 5T5GA 3RU0A 3KMTA 4LDGA 5T0MA 5LSXA 4O30A 3OXFA 3CBMA 5CCMA 1XQHA 4I51A 3TG4A 5F5EA 1ML9A 4QEPA 3RIBA 5EX3A 5TEGA 4JLGA 3S7FA 3M54A 5T0KA 1O9SA 3CBPA 3RQ4A 3OS5A 4YPEA 3F9XA 5F6KC 4NVQA 4QENA 5AYFA 5KJLA 1PEGA 3K5KA 3MO2A 4J7IA 5KJMA 1ZKKA 5TTFA 2QPWA 1N6CA 3QWWA 3OPEA 3S7BA 3F9WA 3M5AA 5HQ8A 2BQZA 2R3AA 3OXLA 1MT6A 4J83A 4MI0A 3S7JA 4IJ8A 5JIYA 3RAYA 1N6AA 3PDNA 3M55A 3QWPA 2W5YA 3M59A 2O8JA 2F69A 3HNAA 4O6FA 3OOIA 2RFIA 3DB5A 5TH7A 4QEOA 1H3IA 3VV0A 4IJDA 3KMJA 4YNPA 5JJ0A 2W5ZA 5EX0A 3S8PA 3IHXA 4NJ5A 3RJWA 5ARFA 3M57A 1N3JA 3S7DA 5LSZA 2G46A 4BUPA 3N71A 5HI7A 4AU7A 4Z4PA 4J7FA 3SW9A 5ARGA 2IGQA 3SWCA 5EG2A 4J8OA 3EP0A 4E47A 3KMAA 3QWVA 4H12A 5CPRB 4RZ0A 1MVXA 3CBOA 5JINA 4MI5A 5KJNA 3MEKA 5F59A 5CCLA 4YNMA 3TG5A 4C1QA 2JV0A 3DALA 3F9ZA 3MO0A 4YPAA 5F6LA 4FMUA 5KJKA 5JHNA 1MVHA 3FPDA 3VUZA 3M53A
chains in the Genus database with same CATH topology
3BO5A 1MUFA 4JDSA 3MO5A 4YPUA 4WUYA 4YNDA 3F9YA 3M58A 3OXGA 3M56A 5T5GA 3RU0A 3KMTA 4LDGA 5T0MA 5LSXA 4O30A 3OXFA 3CBMA 5CCMA 1XQHA 4I51A 3TG4A 5F5EA 1ML9A 4QEPA 3RIBA 5EX3A 5TEGA 4JLGA 3S7FA 3M54A 5T0KA 1O9SA 3CBPA 3RQ4A 3OS5A 4YPEA 3F9XA 5F6KC 4NVQA 4QENA 5AYFA 5KJLA 1PEGA 3K5KA 3MO2A 4J7IA 5KJMA 1ZKKA 5TTFA 2QPWA 1N6CA 3QWWA 3OPEA 3S7BA 3F9WA 3M5AA 5HQ8A 2BQZA 2R3AA 3OXLA 1MT6A 4J83A 4MI0A 3S7JA 4IJ8A 5JIYA 3RAYA 1N6AA 3PDNA 3M55A 3QWPA 2W5YA 3M59A 2O8JA 2F69A 3HNAA 4O6FA 3OOIA 2RFIA 3DB5A 5TH7A 4QEOA 1H3IA 3VV0A 4IJDA 3KMJA 4YNPA 5JJ0A 2W5ZA 5EX0A 3S8PA 3IHXA 4NJ5A 3RJWA 5ARFA 3M57A 1N3JA 3S7DA 5LSZA 2G46A 4BUPA 3N71A 5HI7A 4AU7A 4Z4PA 4J7FA 3SW9A 5ARGA 2IGQA 3SWCA 5EG2A 4J8OA 3EP0A 4E47A 3KMAA 3QWVA 4H12A 5CPRB 4RZ0A 1MVXA 3CBOA 5JINA 4MI5A 5KJNA 3MEKA 5F59A 5CCLA 4YNMA 3TG5A 4C1QA 2JV0A 3DALA 3F9ZA 3MO0A 4YPAA 5F6LA 4FMUA 5KJKA 5JHNA 1MVHA 3FPDA 3VUZA 3M53A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3BO5 A;  1MUF A;  4JDS A;  3MO5 A;  4YPU A;  4WUY A;  4YND A;  3F9Y A;  3M58 A;  3OXG A;  3M56 A;  5T5G A;  3RU0 A;  3KMT A;  4LDG A;  5T0M A;  5LSX A;  4O30 A;  3OXF A;  3CBM A;  5CCM A;  1XQH A;  4I51 A;  3TG4 A;  5F5E A;  1ML9 A;  4QEP A;  3RIB A;  5EX3 A;  5TEG A;  4JLG A;  3S7F A;  3M54 A;  5T0K A;  1O9S A;  3CBP A;  3RQ4 A;  3OS5 A;  4YPE A;  3F9X A;  5F6K C;  4NVQ A;  4QEN A;  5AYF A;  5KJL A;  1PEG A;  3K5K A;  3MO2 A;  4J7I A;  5KJM A;  1ZKK A;  5TTF A;  2QPW A;  1N6C A;  3QWW A;  3OPE A;  3S7B A;  3F9W A;  3M5A A;  5HQ8 A;  2BQZ A;  2R3A A;  3OXL A;  1MT6 A;  4J83 A;  4MI0 A;  3S7J A;  4IJ8 A;  5JIY A;  3RAY A;  1N6A A;  3PDN A;  3M55 A;  3QWP A;  2W5Y A;  3M59 A;  2O8J A;  2F69 A;  3HNA A;  4O6F A;  3OOI A;  2RFI A;  3DB5 A;  5TH7 A;  4QEO A;  1H3I A;  3VV0 A;  4IJD A;  3KMJ A;  4YNP A;  5JJ0 A;  2W5Z A;  5EX0 A;  3S8P A;  3IHX A;  4NJ5 A;  3RJW A;  5ARF A;  3M57 A;  1N3J A;  3S7D A;  5LSZ A;  2G46 A;  4BUP A;  3N71 A;  5HI7 A;  4AU7 A;  4Z4P A;  4J7F A;  3SW9 A;  5ARG A;  2IGQ A;  3SWC A;  5EG2 A;  4J8O A;  3EP0 A;  4E47 A;  3KMA A;  3QWV A;  4H12 A;  5CPR B;  4RZ0 A;  1MVX A;  3CBO A;  5JIN A;  4MI5 A;  5KJN A;  3MEK A;  5F59 A;  5CCL A;  4YNM A;  3TG5 A;  4C1Q A;  2JV0 A;  3DAL A;  3F9Z A;  3MO0 A;  4YPA A;  5F6L A;  4FMU A;  5KJK A;  5JHN A;  1MVH A;  3FPD A;  3VUZ A;  3M53 A; 
#chains in the Genus database with same CATH topology
 3BO5 A;  1MUF A;  4JDS A;  3MO5 A;  4YPU A;  4WUY A;  4YND A;  3F9Y A;  3M58 A;  3OXG A;  3M56 A;  5T5G A;  3RU0 A;  3KMT A;  4LDG A;  5T0M A;  5LSX A;  4O30 A;  3OXF A;  3CBM A;  5CCM A;  1XQH A;  4I51 A;  3TG4 A;  5F5E A;  1ML9 A;  4QEP A;  3RIB A;  5EX3 A;  5TEG A;  4JLG A;  3S7F A;  3M54 A;  5T0K A;  1O9S A;  3CBP A;  3RQ4 A;  3OS5 A;  4YPE A;  3F9X A;  5F6K C;  4NVQ A;  4QEN A;  5AYF A;  5KJL A;  1PEG A;  3K5K A;  3MO2 A;  4J7I A;  5KJM A;  1ZKK A;  5TTF A;  2QPW A;  1N6C A;  3QWW A;  3OPE A;  3S7B A;  3F9W A;  3M5A A;  5HQ8 A;  2BQZ A;  2R3A A;  3OXL A;  1MT6 A;  4J83 A;  4MI0 A;  3S7J A;  4IJ8 A;  5JIY A;  3RAY A;  1N6A A;  3PDN A;  3M55 A;  3QWP A;  2W5Y A;  3M59 A;  2O8J A;  2F69 A;  3HNA A;  4O6F A;  3OOI A;  2RFI A;  3DB5 A;  5TH7 A;  4QEO A;  1H3I A;  3VV0 A;  4IJD A;  3KMJ A;  4YNP A;  5JJ0 A;  2W5Z A;  5EX0 A;  3S8P A;  3IHX A;  4NJ5 A;  3RJW A;  5ARF A;  3M57 A;  1N3J A;  3S7D A;  5LSZ A;  2G46 A;  4BUP A;  3N71 A;  5HI7 A;  4AU7 A;  4Z4P A;  4J7F A;  3SW9 A;  5ARG A;  2IGQ A;  3SWC A;  5EG2 A;  4J8O A;  3EP0 A;  4E47 A;  3KMA A;  3QWV A;  4H12 A;  5CPR B;  4RZ0 A;  1MVX A;  3CBO A;  5JIN A;  4MI5 A;  5KJN A;  3MEK A;  5F59 A;  5CCL A;  4YNM A;  3TG5 A;  4C1Q A;  2JV0 A;  3DAL A;  3F9Z A;  3MO0 A;  4YPA A;  5F6L A;  4FMU A;  5KJK A;  5JHN A;  1MVH A;  3FPD A;  3VUZ A;  3M53 A; 
#chains in the Genus database with same CATH homology
 3BO5 A;  1MUF A;  4JDS A;  3MO5 A;  4YPU A;  4WUY A;  4YND A;  3F9Y A;  3M58 A;  3OXG A;  3M56 A;  5T5G A;  3RU0 A;  3KMT A;  4LDG A;  5T0M A;  5LSX A;  4O30 A;  3OXF A;  3CBM A;  5CCM A;  1XQH A;  4I51 A;  3TG4 A;  5F5E A;  1ML9 A;  4QEP A;  3RIB A;  5EX3 A;  5TEG A;  4JLG A;  3S7F A;  3M54 A;  5T0K A;  1O9S A;  3CBP A;  3RQ4 A;  3OS5 A;  4YPE A;  3F9X A;  5F6K C;  4NVQ A;  4QEN A;  5AYF A;  5KJL A;  1PEG A;  3K5K A;  3MO2 A;  4J7I A;  5KJM A;  1ZKK A;  5TTF A;  2QPW A;  1N6C A;  3QWW A;  3OPE A;  3S7B A;  3F9W A;  3M5A A;  5HQ8 A;  2BQZ A;  2R3A A;  3OXL A;  1MT6 A;  4J83 A;  4MI0 A;  3S7J A;  4IJ8 A;  5JIY A;  3RAY A;  1N6A A;  3PDN A;  3M55 A;  3QWP A;  2W5Y A;  3M59 A;  2O8J A;  2F69 A;  3HNA A;  4O6F A;  3OOI A;  2RFI A;  3DB5 A;  5TH7 A;  4QEO A;  1H3I A;  3VV0 A;  4IJD A;  3KMJ A;  4YNP A;  5JJ0 A;  2W5Z A;  5EX0 A;  3S8P A;  3IHX A;  4NJ5 A;  3RJW A;  5ARF A;  3M57 A;  1N3J A;  3S7D A;  5LSZ A;  2G46 A;  4BUP A;  3N71 A;  5HI7 A;  4AU7 A;  4Z4P A;  4J7F A;  3SW9 A;  5ARG A;  2IGQ A;  3SWC A;  5EG2 A;  4J8O A;  3EP0 A;  4E47 A;  3KMA A;  3QWV A;  4H12 A;  5CPR B;  4RZ0 A;  1MVX A;  3CBO A;  5JIN A;  4MI5 A;  5KJN A;  3MEK A;  5F59 A;  5CCL A;  4YNM A;  3TG5 A;  4C1Q A;  2JV0 A;  3DAL A;  3F9Z A;  3MO0 A;  4YPA A;  5F6L A;  4FMU A;  5KJK A;  5JHN A;  1MVH A;  3FPD A;  3VUZ A;  3M53 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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