3FPDA

G9a-like protein lysine methyltransferase inhibition by bix-01294
Total Genus 61
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
61
sequence length
261
structure length
261
Chain Sequence
b'VERIVSRDIARGYERIPIPCVNAVDSEPCPSNYKYVSQNCVTSPMNIDRNITHLQYCVCIDDCSSSNCMCGQLSMRCWYDKDGRLLPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLDNKDGEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIKGKLFSCRCGSPKCRHS'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Histone-lysine N-methyltransferase, H3 lysine-9 specific 5
molecule tags Transferase
source organism Homo sapiens
publication title Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294.
pubmed doi rcsb
total genus 61
structure length 261
sequence length 261
chains with identical sequence B
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2009-01-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF05033 Pre-SET Pre-SET motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 3fpdA00
5KJKA 5JINA 4LDGA 5KJNA 3M58A 5F5EA 1MVHA 3KMJA 5KJMA 5ARFA 4H12A 3KMAA 3RIBA 3VUZA 5F6LA 1N6CA 3QWVA 4QENA 4C1QA 4YPAA 5T5GA 1ML9A 3OS5A 3M54A 3CBPA 4E47A 4J8OA 4YNDA 3IHXA 3SW9A 5ARGA 5HQ8A 3S7BA 3OXGA 3BO5A 5CPRB 1PEGA 1N3JA 3DALA 3OXFA 2F69A 2RFIA 5JJ0A 1MT6A 2G46A 3RJWA 5HI7A 5TTFA 3RU0A 3F9XA 1H3IA 3M59A 4NJ5A 3CBMA 3S7JA 3MO0A 4JLGA 4QEOA 5T0KA 5JIYA 4IJ8A 4J7FA 3N71A 5TEGA 5LSXA 3TG5A 2IGQA 1MVXA 4JDSA 5AYFA 4I51A 3S7DA 4BUPA 3M5AA 5F6KC 4WUYA 3VV0A 2R3AA 1XQHA 3F9YA 3QWWA 3CBOA 3MO2A 4IJDA 5KJLA 4O30A 5JHNA 3F9ZA 4YPEA 4AU7A 4YNPA 2O8JA 2BQZA 2W5YA 3OPEA 2JV0A 4MI5A 3M53A 3KMTA 3TG4A 1O9SA 3FPDA 3M57A 5F59A 3MO5A 3MEKA 5CCLA 4QEPA 4J83A 1ZKKA 4RZ0A 4NVQA 4O6FA 4MI0A 1N6AA 2QPWA 3RQ4A 4FMUA 5T0MA 3DB5A 5LSZA 5CCMA 4YPUA 5EX3A 5EG2A 5EX0A 3F9WA 3PDNA 3QWPA 1MUFA 4YNMA 4Z4PA 3OXLA 4J7IA 3RAYA 2W5ZA 3M55A 3S7FA 5TH7A 3EP0A 3S8PA 3HNAA 3OOIA 3K5KA 3SWCA 3M56A
chains in the Genus database with same CATH superfamily
5KJKA 5JINA 4LDGA 5KJNA 3M58A 5F5EA 1MVHA 3KMJA 5KJMA 5ARFA 4H12A 3KMAA 3RIBA 3VUZA 5F6LA 1N6CA 3QWVA 4QENA 4C1QA 4YPAA 5T5GA 1ML9A 3OS5A 3M54A 3CBPA 4E47A 4J8OA 4YNDA 3IHXA 3SW9A 5ARGA 5HQ8A 3S7BA 3OXGA 3BO5A 5CPRB 1PEGA 1N3JA 3DALA 3OXFA 2F69A 2RFIA 5JJ0A 1MT6A 2G46A 3RJWA 5HI7A 5TTFA 3RU0A 3F9XA 1H3IA 3M59A 4NJ5A 3CBMA 3S7JA 3MO0A 4JLGA 4QEOA 5T0KA 5JIYA 4IJ8A 4J7FA 3N71A 5TEGA 5LSXA 3TG5A 2IGQA 1MVXA 4JDSA 5AYFA 4I51A 3S7DA 4BUPA 3M5AA 5F6KC 4WUYA 3VV0A 2R3AA 1XQHA 3F9YA 3QWWA 3CBOA 3MO2A 4IJDA 5KJLA 4O30A 5JHNA 3F9ZA 4YPEA 4AU7A 4YNPA 2O8JA 2BQZA 2W5YA 3OPEA 2JV0A 4MI5A 3M53A 3KMTA 3TG4A 1O9SA 3FPDA 3M57A 5F59A 3MO5A 3MEKA 5CCLA 4QEPA 4J83A 1ZKKA 4RZ0A 4NVQA 4O6FA 4MI0A 1N6AA 2QPWA 3RQ4A 4FMUA 5T0MA 3DB5A 5LSZA 5CCMA 4YPUA 5EX3A 5EG2A 5EX0A 3F9WA 3PDNA 3QWPA 1MUFA 4YNMA 4Z4PA 3OXLA 4J7IA 3RAYA 2W5ZA 3M55A 3S7FA 5TH7A 3EP0A 3S8PA 3HNAA 3OOIA 3K5KA 3SWCA 3M56A
chains in the Genus database with same CATH topology
5KJKA 5JINA 4LDGA 5KJNA 3M58A 5F5EA 1MVHA 3KMJA 5KJMA 5ARFA 4H12A 3KMAA 3RIBA 3VUZA 5F6LA 1N6CA 3QWVA 4QENA 4C1QA 4YPAA 5T5GA 1ML9A 3OS5A 3M54A 3CBPA 4E47A 4J8OA 4YNDA 3IHXA 3SW9A 5ARGA 5HQ8A 3S7BA 3OXGA 3BO5A 5CPRB 1PEGA 1N3JA 3DALA 3OXFA 2F69A 2RFIA 5JJ0A 1MT6A 2G46A 3RJWA 5HI7A 5TTFA 3RU0A 3F9XA 1H3IA 3M59A 4NJ5A 3CBMA 3S7JA 3MO0A 4JLGA 4QEOA 5T0KA 5JIYA 4IJ8A 4J7FA 3N71A 5TEGA 5LSXA 3TG5A 2IGQA 1MVXA 4JDSA 5AYFA 4I51A 3S7DA 4BUPA 3M5AA 5F6KC 4WUYA 3VV0A 2R3AA 1XQHA 3F9YA 3QWWA 3CBOA 3MO2A 4IJDA 5KJLA 4O30A 5JHNA 3F9ZA 4YPEA 4AU7A 4YNPA 2O8JA 2BQZA 2W5YA 3OPEA 2JV0A 4MI5A 3M53A 3KMTA 3TG4A 1O9SA 3FPDA 3M57A 5F59A 3MO5A 3MEKA 5CCLA 4QEPA 4J83A 1ZKKA 4RZ0A 4NVQA 4O6FA 4MI0A 1N6AA 2QPWA 3RQ4A 4FMUA 5T0MA 3DB5A 5LSZA 5CCMA 4YPUA 5EX3A 5EG2A 5EX0A 3F9WA 3PDNA 3QWPA 1MUFA 4YNMA 4Z4PA 3OXLA 4J7IA 3RAYA 2W5ZA 3M55A 3S7FA 5TH7A 3EP0A 3S8PA 3HNAA 3OOIA 3K5KA 3SWCA 3M56A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5KJK A;  5JIN A;  4LDG A;  5KJN A;  3M58 A;  5F5E A;  1MVH A;  3KMJ A;  5KJM A;  5ARF A;  4H12 A;  3KMA A;  3RIB A;  3VUZ A;  5F6L A;  1N6C A;  3QWV A;  4QEN A;  4C1Q A;  4YPA A;  5T5G A;  1ML9 A;  3OS5 A;  3M54 A;  3CBP A;  4E47 A;  4J8O A;  4YND A;  3IHX A;  3SW9 A;  5ARG A;  5HQ8 A;  3S7B A;  3OXG A;  3BO5 A;  5CPR B;  1PEG A;  1N3J A;  3DAL A;  3OXF A;  2F69 A;  2RFI A;  5JJ0 A;  1MT6 A;  2G46 A;  3RJW A;  5HI7 A;  5TTF A;  3RU0 A;  3F9X A;  1H3I A;  3M59 A;  4NJ5 A;  3CBM A;  3S7J A;  3MO0 A;  4JLG A;  4QEO A;  5T0K A;  5JIY A;  4IJ8 A;  4J7F A;  3N71 A;  5TEG A;  5LSX A;  3TG5 A;  2IGQ A;  1MVX A;  4JDS A;  5AYF A;  4I51 A;  3S7D A;  4BUP A;  3M5A A;  5F6K C;  4WUY A;  3VV0 A;  2R3A A;  1XQH A;  3F9Y A;  3QWW A;  3CBO A;  3MO2 A;  4IJD A;  5KJL A;  4O30 A;  5JHN A;  3F9Z A;  4YPE A;  4AU7 A;  4YNP A;  2O8J A;  2BQZ A;  2W5Y A;  3OPE A;  2JV0 A;  4MI5 A;  3M53 A;  3KMT A;  3TG4 A;  1O9S A;  3FPD A;  3M57 A;  5F59 A;  3MO5 A;  3MEK A;  5CCL A;  4QEP A;  4J83 A;  1ZKK A;  4RZ0 A;  4NVQ A;  4O6F A;  4MI0 A;  1N6A A;  2QPW A;  3RQ4 A;  4FMU A;  5T0M A;  3DB5 A;  5LSZ A;  5CCM A;  4YPU A;  5EX3 A;  5EG2 A;  5EX0 A;  3F9W A;  3PDN A;  3QWP A;  1MUF A;  4YNM A;  4Z4P A;  3OXL A;  4J7I A;  3RAY A;  2W5Z A;  3M55 A;  3S7F A;  5TH7 A;  3EP0 A;  3S8P A;  3HNA A;  3OOI A;  3K5K A;  3SWC A;  3M56 A; 
#chains in the Genus database with same CATH topology
 5KJK A;  5JIN A;  4LDG A;  5KJN A;  3M58 A;  5F5E A;  1MVH A;  3KMJ A;  5KJM A;  5ARF A;  4H12 A;  3KMA A;  3RIB A;  3VUZ A;  5F6L A;  1N6C A;  3QWV A;  4QEN A;  4C1Q A;  4YPA A;  5T5G A;  1ML9 A;  3OS5 A;  3M54 A;  3CBP A;  4E47 A;  4J8O A;  4YND A;  3IHX A;  3SW9 A;  5ARG A;  5HQ8 A;  3S7B A;  3OXG A;  3BO5 A;  5CPR B;  1PEG A;  1N3J A;  3DAL A;  3OXF A;  2F69 A;  2RFI A;  5JJ0 A;  1MT6 A;  2G46 A;  3RJW A;  5HI7 A;  5TTF A;  3RU0 A;  3F9X A;  1H3I A;  3M59 A;  4NJ5 A;  3CBM A;  3S7J A;  3MO0 A;  4JLG A;  4QEO A;  5T0K A;  5JIY A;  4IJ8 A;  4J7F A;  3N71 A;  5TEG A;  5LSX A;  3TG5 A;  2IGQ A;  1MVX A;  4JDS A;  5AYF A;  4I51 A;  3S7D A;  4BUP A;  3M5A A;  5F6K C;  4WUY A;  3VV0 A;  2R3A A;  1XQH A;  3F9Y A;  3QWW A;  3CBO A;  3MO2 A;  4IJD A;  5KJL A;  4O30 A;  5JHN A;  3F9Z A;  4YPE A;  4AU7 A;  4YNP A;  2O8J A;  2BQZ A;  2W5Y A;  3OPE A;  2JV0 A;  4MI5 A;  3M53 A;  3KMT A;  3TG4 A;  1O9S A;  3FPD A;  3M57 A;  5F59 A;  3MO5 A;  3MEK A;  5CCL A;  4QEP A;  4J83 A;  1ZKK A;  4RZ0 A;  4NVQ A;  4O6F A;  4MI0 A;  1N6A A;  2QPW A;  3RQ4 A;  4FMU A;  5T0M A;  3DB5 A;  5LSZ A;  5CCM A;  4YPU A;  5EX3 A;  5EG2 A;  5EX0 A;  3F9W A;  3PDN A;  3QWP A;  1MUF A;  4YNM A;  4Z4P A;  3OXL A;  4J7I A;  3RAY A;  2W5Z A;  3M55 A;  3S7F A;  5TH7 A;  3EP0 A;  3S8P A;  3HNA A;  3OOI A;  3K5K A;  3SWC A;  3M56 A; 
#chains in the Genus database with same CATH homology
 5KJK A;  5JIN A;  4LDG A;  5KJN A;  3M58 A;  5F5E A;  1MVH A;  3KMJ A;  5KJM A;  5ARF A;  4H12 A;  3KMA A;  3RIB A;  3VUZ A;  5F6L A;  1N6C A;  3QWV A;  4QEN A;  4C1Q A;  4YPA A;  5T5G A;  1ML9 A;  3OS5 A;  3M54 A;  3CBP A;  4E47 A;  4J8O A;  4YND A;  3IHX A;  3SW9 A;  5ARG A;  5HQ8 A;  3S7B A;  3OXG A;  3BO5 A;  5CPR B;  1PEG A;  1N3J A;  3DAL A;  3OXF A;  2F69 A;  2RFI A;  5JJ0 A;  1MT6 A;  2G46 A;  3RJW A;  5HI7 A;  5TTF A;  3RU0 A;  3F9X A;  1H3I A;  3M59 A;  4NJ5 A;  3CBM A;  3S7J A;  3MO0 A;  4JLG A;  4QEO A;  5T0K A;  5JIY A;  4IJ8 A;  4J7F A;  3N71 A;  5TEG A;  5LSX A;  3TG5 A;  2IGQ A;  1MVX A;  4JDS A;  5AYF A;  4I51 A;  3S7D A;  4BUP A;  3M5A A;  5F6K C;  4WUY A;  3VV0 A;  2R3A A;  1XQH A;  3F9Y A;  3QWW A;  3CBO A;  3MO2 A;  4IJD A;  5KJL A;  4O30 A;  5JHN A;  3F9Z A;  4YPE A;  4AU7 A;  4YNP A;  2O8J A;  2BQZ A;  2W5Y A;  3OPE A;  2JV0 A;  4MI5 A;  3M53 A;  3KMT A;  3TG4 A;  1O9S A;  3FPD A;  3M57 A;  5F59 A;  3MO5 A;  3MEK A;  5CCL A;  4QEP A;  4J83 A;  1ZKK A;  4RZ0 A;  4NVQ A;  4O6F A;  4MI0 A;  1N6A A;  2QPW A;  3RQ4 A;  4FMU A;  5T0M A;  3DB5 A;  5LSZ A;  5CCM A;  4YPU A;  5EX3 A;  5EG2 A;  5EX0 A;  3F9W A;  3PDN A;  3QWP A;  1MUF A;  4YNM A;  4Z4P A;  3OXL A;  4J7I A;  3RAY A;  2W5Z A;  3M55 A;  3S7F A;  5TH7 A;  3EP0 A;  3S8P A;  3HNA A;  3OOI A;  3K5K A;  3SWC A;  3M56 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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