3RJWA

Crystal structure of histone lysine methyltransferase g9a with an inhibitor
Total Genus 67
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
67
sequence length
270
structure length
268
Chain Sequence
TEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKYFTCQCGSEKCKHSAEAIALEQS
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Transferase/transferase inhibitor
molecule keywords Histone-lysine N-methyltransferase EHMT2
publication title A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells.
pubmed doi rcsb
source organism Homo sapiens
total genus 67
structure length 268
sequence length 270
chains with identical sequence B
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2011-04-15

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF05033 Pre-SET Pre-SET motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 3rjwA00
5JJ0A 4MI0A 5LSZA 4H12A 3FPDA 3MO0A 3M58A 3OXGA 3CBMA 3S7BA 3QWVA 2RFIA 1PEGA 4IJDA 3M57A 5CPRB 4Z4PA 4QENA 5T5GA 4NVQA 5KJKA 5T0MA 3RU0A 3SWCA 5F6LA 5JINA 1O9SA 5F59A 3HNAA 1N6CA 3M59A 5T0KA 4AU7A 3F9ZA 4I51A 3F9WA 3CBPA 5TTFA 3OXLA 5KJNA 2W5YA 4O6FA 2G46A 3M55A 5HI7A 4QEOA 1MT6A 1XQHA 4IJ8A 4J83A 4NJ5A 4RZ0A 3TG4A 2F69A 1H3IA 5EG2A 5F5EA 5AYFA 3MO5A 5LSXA 4J7FA 3DALA 3MEKA 3VUZA 3PDNA 4MI5A 4E47A 3VV0A 4YPAA 3M54A 3RAYA 3S7FA 4C1QA 3IHXA 3S7DA 4JLGA 1ML9A 2IGQA 3N71A 3OOIA 2O8JA 2W5ZA 4BUPA 4JDSA 3M5AA 5TH7A 5EX0A 4QEPA 3EP0A 2BQZA 3QWPA 3BO5A 3RQ4A 4YNPA 3KMAA 5KJMA 1ZKKA 2JV0A 3M53A 1MUFA 4J7IA 1N3JA 3RIBA 5EX3A 4FMUA 3MO2A 3RJWA 5CCMA 4WUYA 2R3AA 3KMJA 3F9YA 3S8PA 3SW9A 5JIYA 5KJLA 4YPEA 3S7JA 5ARGA 5F6KC 3KMTA 3OS5A 1MVHA 5ARFA 2QPWA 1N6AA 4J8OA 5TEGA 5CCLA 3DB5A 4LDGA 4YPUA 3CBOA 3F9XA 4O30A 3OXFA 3TG5A 5HQ8A 3K5KA 3QWWA 3OPEA 1MVXA 3M56A 4YNDA 4YNMA 5JHNA
chains in the Genus database with same CATH superfamily
5JJ0A 4MI0A 5LSZA 4H12A 3FPDA 3MO0A 3M58A 3OXGA 3CBMA 3S7BA 3QWVA 2RFIA 1PEGA 4IJDA 3M57A 5CPRB 4Z4PA 4QENA 5T5GA 4NVQA 5KJKA 5T0MA 3RU0A 3SWCA 5F6LA 5JINA 1O9SA 5F59A 3HNAA 1N6CA 3M59A 5T0KA 4AU7A 3F9ZA 4I51A 3F9WA 3CBPA 5TTFA 3OXLA 5KJNA 2W5YA 4O6FA 2G46A 3M55A 5HI7A 4QEOA 1MT6A 1XQHA 4IJ8A 4J83A 4NJ5A 4RZ0A 3TG4A 2F69A 1H3IA 5EG2A 5F5EA 5AYFA 3MO5A 5LSXA 4J7FA 3DALA 3MEKA 3VUZA 3PDNA 4MI5A 4E47A 3VV0A 4YPAA 3M54A 3RAYA 3S7FA 4C1QA 3IHXA 3S7DA 4JLGA 1ML9A 2IGQA 3N71A 3OOIA 2O8JA 2W5ZA 4BUPA 4JDSA 3M5AA 5TH7A 5EX0A 4QEPA 3EP0A 2BQZA 3QWPA 3BO5A 3RQ4A 4YNPA 3KMAA 5KJMA 1ZKKA 2JV0A 3M53A 1MUFA 4J7IA 1N3JA 3RIBA 5EX3A 4FMUA 3MO2A 3RJWA 5CCMA 4WUYA 2R3AA 3KMJA 3F9YA 3S8PA 3SW9A 5JIYA 5KJLA 4YPEA 3S7JA 5ARGA 5F6KC 3KMTA 3OS5A 1MVHA 5ARFA 2QPWA 1N6AA 4J8OA 5TEGA 5CCLA 3DB5A 4LDGA 4YPUA 3CBOA 3F9XA 4O30A 3OXFA 3TG5A 5HQ8A 3K5KA 3QWWA 3OPEA 1MVXA 3M56A 4YNDA 4YNMA 5JHNA
chains in the Genus database with same CATH topology
5JJ0A 4MI0A 5LSZA 4H12A 3FPDA 3MO0A 3M58A 3OXGA 3CBMA 3S7BA 3QWVA 2RFIA 1PEGA 4IJDA 3M57A 5CPRB 4Z4PA 4QENA 5T5GA 4NVQA 5KJKA 5T0MA 3RU0A 3SWCA 5F6LA 5JINA 1O9SA 5F59A 3HNAA 1N6CA 3M59A 5T0KA 4AU7A 3F9ZA 4I51A 3F9WA 3CBPA 5TTFA 3OXLA 5KJNA 2W5YA 4O6FA 2G46A 3M55A 5HI7A 4QEOA 1MT6A 1XQHA 4IJ8A 4J83A 4NJ5A 4RZ0A 3TG4A 2F69A 1H3IA 5EG2A 5F5EA 5AYFA 3MO5A 5LSXA 4J7FA 3DALA 3MEKA 3VUZA 3PDNA 4MI5A 4E47A 3VV0A 4YPAA 3M54A 3RAYA 3S7FA 4C1QA 3IHXA 3S7DA 4JLGA 1ML9A 2IGQA 3N71A 3OOIA 2O8JA 2W5ZA 4BUPA 4JDSA 3M5AA 5TH7A 5EX0A 4QEPA 3EP0A 2BQZA 3QWPA 3BO5A 3RQ4A 4YNPA 3KMAA 5KJMA 1ZKKA 2JV0A 3M53A 1MUFA 4J7IA 1N3JA 3RIBA 5EX3A 4FMUA 3MO2A 3RJWA 5CCMA 4WUYA 2R3AA 3KMJA 3F9YA 3S8PA 3SW9A 5JIYA 5KJLA 4YPEA 3S7JA 5ARGA 5F6KC 3KMTA 3OS5A 1MVHA 5ARFA 2QPWA 1N6AA 4J8OA 5TEGA 5CCLA 3DB5A 4LDGA 4YPUA 3CBOA 3F9XA 4O30A 3OXFA 3TG5A 5HQ8A 3K5KA 3QWWA 3OPEA 1MVXA 3M56A 4YNDA 4YNMA 5JHNA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5JJ0 A;  4MI0 A;  5LSZ A;  4H12 A;  3FPD A;  3MO0 A;  3M58 A;  3OXG A;  3CBM A;  3S7B A;  3QWV A;  2RFI A;  1PEG A;  4IJD A;  3M57 A;  5CPR B;  4Z4P A;  4QEN A;  5T5G A;  4NVQ A;  5KJK A;  5T0M A;  3RU0 A;  3SWC A;  5F6L A;  5JIN A;  1O9S A;  5F59 A;  3HNA A;  1N6C A;  3M59 A;  5T0K A;  4AU7 A;  3F9Z A;  4I51 A;  3F9W A;  3CBP A;  5TTF A;  3OXL A;  5KJN A;  2W5Y A;  4O6F A;  2G46 A;  3M55 A;  5HI7 A;  4QEO A;  1MT6 A;  1XQH A;  4IJ8 A;  4J83 A;  4NJ5 A;  4RZ0 A;  3TG4 A;  2F69 A;  1H3I A;  5EG2 A;  5F5E A;  5AYF A;  3MO5 A;  5LSX A;  4J7F A;  3DAL A;  3MEK A;  3VUZ A;  3PDN A;  4MI5 A;  4E47 A;  3VV0 A;  4YPA A;  3M54 A;  3RAY A;  3S7F A;  4C1Q A;  3IHX A;  3S7D A;  4JLG A;  1ML9 A;  2IGQ A;  3N71 A;  3OOI A;  2O8J A;  2W5Z A;  4BUP A;  4JDS A;  3M5A A;  5TH7 A;  5EX0 A;  4QEP A;  3EP0 A;  2BQZ A;  3QWP A;  3BO5 A;  3RQ4 A;  4YNP A;  3KMA A;  5KJM A;  1ZKK A;  2JV0 A;  3M53 A;  1MUF A;  4J7I A;  1N3J A;  3RIB A;  5EX3 A;  4FMU A;  3MO2 A;  3RJW A;  5CCM A;  4WUY A;  2R3A A;  3KMJ A;  3F9Y A;  3S8P A;  3SW9 A;  5JIY A;  5KJL A;  4YPE A;  3S7J A;  5ARG A;  5F6K C;  3KMT A;  3OS5 A;  1MVH A;  5ARF A;  2QPW A;  1N6A A;  4J8O A;  5TEG A;  5CCL A;  3DB5 A;  4LDG A;  4YPU A;  3CBO A;  3F9X A;  4O30 A;  3OXF A;  3TG5 A;  5HQ8 A;  3K5K A;  3QWW A;  3OPE A;  1MVX A;  3M56 A;  4YND A;  4YNM A;  5JHN A; 
#chains in the Genus database with same CATH topology
 5JJ0 A;  4MI0 A;  5LSZ A;  4H12 A;  3FPD A;  3MO0 A;  3M58 A;  3OXG A;  3CBM A;  3S7B A;  3QWV A;  2RFI A;  1PEG A;  4IJD A;  3M57 A;  5CPR B;  4Z4P A;  4QEN A;  5T5G A;  4NVQ A;  5KJK A;  5T0M A;  3RU0 A;  3SWC A;  5F6L A;  5JIN A;  1O9S A;  5F59 A;  3HNA A;  1N6C A;  3M59 A;  5T0K A;  4AU7 A;  3F9Z A;  4I51 A;  3F9W A;  3CBP A;  5TTF A;  3OXL A;  5KJN A;  2W5Y A;  4O6F A;  2G46 A;  3M55 A;  5HI7 A;  4QEO A;  1MT6 A;  1XQH A;  4IJ8 A;  4J83 A;  4NJ5 A;  4RZ0 A;  3TG4 A;  2F69 A;  1H3I A;  5EG2 A;  5F5E A;  5AYF A;  3MO5 A;  5LSX A;  4J7F A;  3DAL A;  3MEK A;  3VUZ A;  3PDN A;  4MI5 A;  4E47 A;  3VV0 A;  4YPA A;  3M54 A;  3RAY A;  3S7F A;  4C1Q A;  3IHX A;  3S7D A;  4JLG A;  1ML9 A;  2IGQ A;  3N71 A;  3OOI A;  2O8J A;  2W5Z A;  4BUP A;  4JDS A;  3M5A A;  5TH7 A;  5EX0 A;  4QEP A;  3EP0 A;  2BQZ A;  3QWP A;  3BO5 A;  3RQ4 A;  4YNP A;  3KMA A;  5KJM A;  1ZKK A;  2JV0 A;  3M53 A;  1MUF A;  4J7I A;  1N3J A;  3RIB A;  5EX3 A;  4FMU A;  3MO2 A;  3RJW A;  5CCM A;  4WUY A;  2R3A A;  3KMJ A;  3F9Y A;  3S8P A;  3SW9 A;  5JIY A;  5KJL A;  4YPE A;  3S7J A;  5ARG A;  5F6K C;  3KMT A;  3OS5 A;  1MVH A;  5ARF A;  2QPW A;  1N6A A;  4J8O A;  5TEG A;  5CCL A;  3DB5 A;  4LDG A;  4YPU A;  3CBO A;  3F9X A;  4O30 A;  3OXF A;  3TG5 A;  5HQ8 A;  3K5K A;  3QWW A;  3OPE A;  1MVX A;  3M56 A;  4YND A;  4YNM A;  5JHN A; 
#chains in the Genus database with same CATH homology
 5JJ0 A;  4MI0 A;  5LSZ A;  4H12 A;  3FPD A;  3MO0 A;  3M58 A;  3OXG A;  3CBM A;  3S7B A;  3QWV A;  2RFI A;  1PEG A;  4IJD A;  3M57 A;  5CPR B;  4Z4P A;  4QEN A;  5T5G A;  4NVQ A;  5KJK A;  5T0M A;  3RU0 A;  3SWC A;  5F6L A;  5JIN A;  1O9S A;  5F59 A;  3HNA A;  1N6C A;  3M59 A;  5T0K A;  4AU7 A;  3F9Z A;  4I51 A;  3F9W A;  3CBP A;  5TTF A;  3OXL A;  5KJN A;  2W5Y A;  4O6F A;  2G46 A;  3M55 A;  5HI7 A;  4QEO A;  1MT6 A;  1XQH A;  4IJ8 A;  4J83 A;  4NJ5 A;  4RZ0 A;  3TG4 A;  2F69 A;  1H3I A;  5EG2 A;  5F5E A;  5AYF A;  3MO5 A;  5LSX A;  4J7F A;  3DAL A;  3MEK A;  3VUZ A;  3PDN A;  4MI5 A;  4E47 A;  3VV0 A;  4YPA A;  3M54 A;  3RAY A;  3S7F A;  4C1Q A;  3IHX A;  3S7D A;  4JLG A;  1ML9 A;  2IGQ A;  3N71 A;  3OOI A;  2O8J A;  2W5Z A;  4BUP A;  4JDS A;  3M5A A;  5TH7 A;  5EX0 A;  4QEP A;  3EP0 A;  2BQZ A;  3QWP A;  3BO5 A;  3RQ4 A;  4YNP A;  3KMA A;  5KJM A;  1ZKK A;  2JV0 A;  3M53 A;  1MUF A;  4J7I A;  1N3J A;  3RIB A;  5EX3 A;  4FMU A;  3MO2 A;  3RJW A;  5CCM A;  4WUY A;  2R3A A;  3KMJ A;  3F9Y A;  3S8P A;  3SW9 A;  5JIY A;  5KJL A;  4YPE A;  3S7J A;  5ARG A;  5F6K C;  3KMT A;  3OS5 A;  1MVH A;  5ARF A;  2QPW A;  1N6A A;  4J8O A;  5TEG A;  5CCL A;  3DB5 A;  4LDG A;  4YPU A;  3CBO A;  3F9X A;  4O30 A;  3OXF A;  3TG5 A;  5HQ8 A;  3K5K A;  3QWW A;  3OPE A;  1MVX A;  3M56 A;  4YND A;  4YNM A;  5JHN A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...