3RJWA

Crystal structure of histone lysine methyltransferase g9a with an inhibitor
Total Genus 67
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
67
sequence length
270
structure length
268
Chain Sequence
b'TEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKYFTCQCGSEKCKHSAEAIALEQS'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Histone-lysine N-methyltransferase EHMT2
publication title A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Transferase/transferase inhibitor
total genus 67
structure length 268
sequence length 270
chains with identical sequence B
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2011-04-15

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF05033 Pre-SET Pre-SET motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 3rjwA00
5CPRB 4J83A 3DB5A 3M58A 5JIYA 3SW9A 3RIBA 3BO5A 3EP0A 2R3AA 3KMTA 3M55A 3TG5A 3PDNA 3M54A 5JHNA 1MVXA 4RZ0A 2W5ZA 2G46A 1N3JA 4YPAA 4LDGA 3DALA 1H3IA 4JDSA 5TEGA 4E47A 3S7BA 1ML9A 3VV0A 4IJDA 4JLGA 3KMJA 3N71A 3CBPA 4WUYA 4YPUA 3SWCA 1MVHA 1ZKKA 1MT6A 3MO5A 5T5GA 4YNDA 3QWWA 3F9XA 5TH7A 4YNMA 3OXLA 4IJ8A 3S7FA 4MI0A 3M5AA 3F9ZA 3QWPA 4YNPA 5F59A 5CCLA 5ARFA 3OS5A 5ARGA 3TG4A 2JV0A 5HI7A 5F5EA 3RQ4A 2BQZA 3RU0A 3S7DA 2QPWA 3MO2A 3F9YA 4QENA 3OXFA 4AU7A 3OOIA 4O6FA 5KJNA 5AYFA 3IHXA 5EX0A 1XQHA 3M56A 4J7FA 5CCMA 4BUPA 4Z4PA 4QEOA 5F6KC 3KMAA 3RJWA 1N6CA 3FPDA 4NJ5A 3S8PA 3CBOA 3MEKA 2F69A 5T0KA 4NVQA 4O30A 5KJKA 4H12A 4QEPA 5JINA 5HQ8A 3F9WA 3MO0A 1PEGA 5EX3A 1O9SA 1MUFA 2O8JA 4I51A 3S7JA 3M53A 4MI5A 3OPEA 5LSZA 5T0MA 3M57A 2W5YA 3CBMA 5KJMA 4J8OA 2RFIA 5KJLA 3RAYA 3VUZA 5LSXA 3QWVA 5TTFA 2IGQA 3OXGA 4J7IA 5EG2A 3K5KA 4C1QA 5F6LA 3M59A 4FMUA 5JJ0A 3HNAA 1N6AA 4YPEA
chains in the Genus database with same CATH superfamily
5CPRB 4J83A 3DB5A 3M58A 5JIYA 3SW9A 3RIBA 3BO5A 3EP0A 2R3AA 3KMTA 3M55A 3TG5A 3PDNA 3M54A 5JHNA 1MVXA 4RZ0A 2W5ZA 2G46A 1N3JA 4YPAA 4LDGA 3DALA 1H3IA 4JDSA 5TEGA 4E47A 3S7BA 1ML9A 3VV0A 4IJDA 4JLGA 3KMJA 3N71A 3CBPA 4WUYA 4YPUA 3SWCA 1MVHA 1ZKKA 1MT6A 3MO5A 5T5GA 4YNDA 3QWWA 3F9XA 5TH7A 4YNMA 3OXLA 4IJ8A 3S7FA 4MI0A 3M5AA 3F9ZA 3QWPA 4YNPA 5F59A 5CCLA 5ARFA 3OS5A 5ARGA 3TG4A 2JV0A 5HI7A 5F5EA 3RQ4A 2BQZA 3RU0A 3S7DA 2QPWA 3MO2A 3F9YA 4QENA 3OXFA 4AU7A 3OOIA 4O6FA 5KJNA 5AYFA 3IHXA 5EX0A 1XQHA 3M56A 4J7FA 5CCMA 4BUPA 4Z4PA 4QEOA 5F6KC 3KMAA 3RJWA 1N6CA 3FPDA 4NJ5A 3S8PA 3CBOA 3MEKA 2F69A 5T0KA 4NVQA 4O30A 5KJKA 4H12A 4QEPA 5JINA 5HQ8A 3F9WA 3MO0A 1PEGA 5EX3A 1O9SA 1MUFA 2O8JA 4I51A 3S7JA 3M53A 4MI5A 3OPEA 5LSZA 5T0MA 3M57A 2W5YA 3CBMA 5KJMA 4J8OA 2RFIA 5KJLA 3RAYA 3VUZA 5LSXA 3QWVA 5TTFA 2IGQA 3OXGA 4J7IA 5EG2A 3K5KA 4C1QA 5F6LA 3M59A 4FMUA 5JJ0A 3HNAA 1N6AA 4YPEA
chains in the Genus database with same CATH topology
5CPRB 4J83A 3DB5A 3M58A 5JIYA 3SW9A 3RIBA 3BO5A 3EP0A 2R3AA 3KMTA 3M55A 3TG5A 3PDNA 3M54A 5JHNA 1MVXA 4RZ0A 2W5ZA 2G46A 1N3JA 4YPAA 4LDGA 3DALA 1H3IA 4JDSA 5TEGA 4E47A 3S7BA 1ML9A 3VV0A 4IJDA 4JLGA 3KMJA 3N71A 3CBPA 4WUYA 4YPUA 3SWCA 1MVHA 1ZKKA 1MT6A 3MO5A 5T5GA 4YNDA 3QWWA 3F9XA 5TH7A 4YNMA 3OXLA 4IJ8A 3S7FA 4MI0A 3M5AA 3F9ZA 3QWPA 4YNPA 5F59A 5CCLA 5ARFA 3OS5A 5ARGA 3TG4A 2JV0A 5HI7A 5F5EA 3RQ4A 2BQZA 3RU0A 3S7DA 2QPWA 3MO2A 3F9YA 4QENA 3OXFA 4AU7A 3OOIA 4O6FA 5KJNA 5AYFA 3IHXA 5EX0A 1XQHA 3M56A 4J7FA 5CCMA 4BUPA 4Z4PA 4QEOA 5F6KC 3KMAA 3RJWA 1N6CA 3FPDA 4NJ5A 3S8PA 3CBOA 3MEKA 2F69A 5T0KA 4NVQA 4O30A 5KJKA 4H12A 4QEPA 5JINA 5HQ8A 3F9WA 3MO0A 1PEGA 5EX3A 1O9SA 1MUFA 2O8JA 4I51A 3S7JA 3M53A 4MI5A 3OPEA 5LSZA 5T0MA 3M57A 2W5YA 3CBMA 5KJMA 4J8OA 2RFIA 5KJLA 3RAYA 3VUZA 5LSXA 3QWVA 5TTFA 2IGQA 3OXGA 4J7IA 5EG2A 3K5KA 4C1QA 5F6LA 3M59A 4FMUA 5JJ0A 3HNAA 1N6AA 4YPEA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5CPR B;  4J83 A;  3DB5 A;  3M58 A;  5JIY A;  3SW9 A;  3RIB A;  3BO5 A;  3EP0 A;  2R3A A;  3KMT A;  3M55 A;  3TG5 A;  3PDN A;  3M54 A;  5JHN A;  1MVX A;  4RZ0 A;  2W5Z A;  2G46 A;  1N3J A;  4YPA A;  4LDG A;  3DAL A;  1H3I A;  4JDS A;  5TEG A;  4E47 A;  3S7B A;  1ML9 A;  3VV0 A;  4IJD A;  4JLG A;  3KMJ A;  3N71 A;  3CBP A;  4WUY A;  4YPU A;  3SWC A;  1MVH A;  1ZKK A;  1MT6 A;  3MO5 A;  5T5G A;  4YND A;  3QWW A;  3F9X A;  5TH7 A;  4YNM A;  3OXL A;  4IJ8 A;  3S7F A;  4MI0 A;  3M5A A;  3F9Z A;  3QWP A;  4YNP A;  5F59 A;  5CCL A;  5ARF A;  3OS5 A;  5ARG A;  3TG4 A;  2JV0 A;  5HI7 A;  5F5E A;  3RQ4 A;  2BQZ A;  3RU0 A;  3S7D A;  2QPW A;  3MO2 A;  3F9Y A;  4QEN A;  3OXF A;  4AU7 A;  3OOI A;  4O6F A;  5KJN A;  5AYF A;  3IHX A;  5EX0 A;  1XQH A;  3M56 A;  4J7F A;  5CCM A;  4BUP A;  4Z4P A;  4QEO A;  5F6K C;  3KMA A;  3RJW A;  1N6C A;  3FPD A;  4NJ5 A;  3S8P A;  3CBO A;  3MEK A;  2F69 A;  5T0K A;  4NVQ A;  4O30 A;  5KJK A;  4H12 A;  4QEP A;  5JIN A;  5HQ8 A;  3F9W A;  3MO0 A;  1PEG A;  5EX3 A;  1O9S A;  1MUF A;  2O8J A;  4I51 A;  3S7J A;  3M53 A;  4MI5 A;  3OPE A;  5LSZ A;  5T0M A;  3M57 A;  2W5Y A;  3CBM A;  5KJM A;  4J8O A;  2RFI A;  5KJL A;  3RAY A;  3VUZ A;  5LSX A;  3QWV A;  5TTF A;  2IGQ A;  3OXG A;  4J7I A;  5EG2 A;  3K5K A;  4C1Q A;  5F6L A;  3M59 A;  4FMU A;  5JJ0 A;  3HNA A;  1N6A A;  4YPE A; 
#chains in the Genus database with same CATH topology
 5CPR B;  4J83 A;  3DB5 A;  3M58 A;  5JIY A;  3SW9 A;  3RIB A;  3BO5 A;  3EP0 A;  2R3A A;  3KMT A;  3M55 A;  3TG5 A;  3PDN A;  3M54 A;  5JHN A;  1MVX A;  4RZ0 A;  2W5Z A;  2G46 A;  1N3J A;  4YPA A;  4LDG A;  3DAL A;  1H3I A;  4JDS A;  5TEG A;  4E47 A;  3S7B A;  1ML9 A;  3VV0 A;  4IJD A;  4JLG A;  3KMJ A;  3N71 A;  3CBP A;  4WUY A;  4YPU A;  3SWC A;  1MVH A;  1ZKK A;  1MT6 A;  3MO5 A;  5T5G A;  4YND A;  3QWW A;  3F9X A;  5TH7 A;  4YNM A;  3OXL A;  4IJ8 A;  3S7F A;  4MI0 A;  3M5A A;  3F9Z A;  3QWP A;  4YNP A;  5F59 A;  5CCL A;  5ARF A;  3OS5 A;  5ARG A;  3TG4 A;  2JV0 A;  5HI7 A;  5F5E A;  3RQ4 A;  2BQZ A;  3RU0 A;  3S7D A;  2QPW A;  3MO2 A;  3F9Y A;  4QEN A;  3OXF A;  4AU7 A;  3OOI A;  4O6F A;  5KJN A;  5AYF A;  3IHX A;  5EX0 A;  1XQH A;  3M56 A;  4J7F A;  5CCM A;  4BUP A;  4Z4P A;  4QEO A;  5F6K C;  3KMA A;  3RJW A;  1N6C A;  3FPD A;  4NJ5 A;  3S8P A;  3CBO A;  3MEK A;  2F69 A;  5T0K A;  4NVQ A;  4O30 A;  5KJK A;  4H12 A;  4QEP A;  5JIN A;  5HQ8 A;  3F9W A;  3MO0 A;  1PEG A;  5EX3 A;  1O9S A;  1MUF A;  2O8J A;  4I51 A;  3S7J A;  3M53 A;  4MI5 A;  3OPE A;  5LSZ A;  5T0M A;  3M57 A;  2W5Y A;  3CBM A;  5KJM A;  4J8O A;  2RFI A;  5KJL A;  3RAY A;  3VUZ A;  5LSX A;  3QWV A;  5TTF A;  2IGQ A;  3OXG A;  4J7I A;  5EG2 A;  3K5K A;  4C1Q A;  5F6L A;  3M59 A;  4FMU A;  5JJ0 A;  3HNA A;  1N6A A;  4YPE A; 
#chains in the Genus database with same CATH homology
 5CPR B;  4J83 A;  3DB5 A;  3M58 A;  5JIY A;  3SW9 A;  3RIB A;  3BO5 A;  3EP0 A;  2R3A A;  3KMT A;  3M55 A;  3TG5 A;  3PDN A;  3M54 A;  5JHN A;  1MVX A;  4RZ0 A;  2W5Z A;  2G46 A;  1N3J A;  4YPA A;  4LDG A;  3DAL A;  1H3I A;  4JDS A;  5TEG A;  4E47 A;  3S7B A;  1ML9 A;  3VV0 A;  4IJD A;  4JLG A;  3KMJ A;  3N71 A;  3CBP A;  4WUY A;  4YPU A;  3SWC A;  1MVH A;  1ZKK A;  1MT6 A;  3MO5 A;  5T5G A;  4YND A;  3QWW A;  3F9X A;  5TH7 A;  4YNM A;  3OXL A;  4IJ8 A;  3S7F A;  4MI0 A;  3M5A A;  3F9Z A;  3QWP A;  4YNP A;  5F59 A;  5CCL A;  5ARF A;  3OS5 A;  5ARG A;  3TG4 A;  2JV0 A;  5HI7 A;  5F5E A;  3RQ4 A;  2BQZ A;  3RU0 A;  3S7D A;  2QPW A;  3MO2 A;  3F9Y A;  4QEN A;  3OXF A;  4AU7 A;  3OOI A;  4O6F A;  5KJN A;  5AYF A;  3IHX A;  5EX0 A;  1XQH A;  3M56 A;  4J7F A;  5CCM A;  4BUP A;  4Z4P A;  4QEO A;  5F6K C;  3KMA A;  3RJW A;  1N6C A;  3FPD A;  4NJ5 A;  3S8P A;  3CBO A;  3MEK A;  2F69 A;  5T0K A;  4NVQ A;  4O30 A;  5KJK A;  4H12 A;  4QEP A;  5JIN A;  5HQ8 A;  3F9W A;  3MO0 A;  1PEG A;  5EX3 A;  1O9S A;  1MUF A;  2O8J A;  4I51 A;  3S7J A;  3M53 A;  4MI5 A;  3OPE A;  5LSZ A;  5T0M A;  3M57 A;  2W5Y A;  3CBM A;  5KJM A;  4J8O A;  2RFI A;  5KJL A;  3RAY A;  3VUZ A;  5LSX A;  3QWV A;  5TTF A;  2IGQ A;  3OXG A;  4J7I A;  5EG2 A;  3K5K A;  4C1Q A;  5F6L A;  3M59 A;  4FMU A;  5JJ0 A;  3HNA A;  1N6A A;  4YPE A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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