3RJWA

Crystal structure of histone lysine methyltransferase g9a with an inhibitor
Total Genus 67
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
67
sequence length
270
structure length
268
Chain Sequence
TEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKYFTCQCGSEKCKHSAEAIALEQS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Histone-lysine N-methyltransferase EHMT2
publication title A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Transferase/transferase inhibitor
total genus 67
structure length 268
sequence length 270
chains with identical sequence B
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2011-04-15

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF05033 Pre-SET Pre-SET motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 3rjwA00
2IGQA 3OXLA 1MUFA 3VUZA 4YNPA 3RU0A 5JHNA 3IHXA 5KJKA 2W5YA 3S8PA 1N3JA 3MO2A 4MI5A 3M58A 5ARFA 4YNDA 4O30A 5TH7A 5TTFA 3HNAA 3TG5A 5F6KC 5EX3A 4RZ0A 3F9WA 4NVQA 3M53A 3M55A 4AU7A 3MEKA 3M59A 4YPAA 4JDSA 4IJDA 3OXGA 3QWPA 4JLGA 2O8JA 4QEPA 3MO5A 5KJMA 5HQ8A 4IJ8A 2G46A 2R3AA 4Z4PA 1N6AA 5HI7A 2JV0A 3M56A 2QPWA 5T0KA 3RIBA 4O6FA 5LSZA 4YNMA 4QENA 3CBMA 3KMJA 3OXFA 1H3IA 3K5KA 3CBOA 4LDGA 5F59A 5CCLA 4YPUA 5T0MA 5CCMA 2W5ZA 3S7BA 4I51A 4J7FA 3QWVA 5AYFA 3BO5A 1MVXA 5EG2A 3S7JA 5ARGA 3FPDA 3N71A 3F9XA 3RJWA 3OPEA 5CPRB 3QWWA 4FMUA 3OOIA 4H12A 5KJNA 4E47A 4WUYA 5EX0A 5KJLA 3F9YA 5T5GA 3S7FA 1XQHA 3VV0A 3KMTA 1PEGA 3RAYA 2BQZA 5JINA 3RQ4A 3DALA 5F5EA 3S7DA 1ZKKA 5F6LA 3KMAA 3EP0A 3PDNA 5JJ0A 4BUPA 2RFIA 4C1QA 3M57A 5TEGA 5LSXA 4YPEA 4NJ5A 1O9SA 1N6CA 3SWCA 3F9ZA 5JIYA 4J8OA 3SW9A 4QEOA 3M5AA 4J7IA 4MI0A 3DB5A 1MVHA 3OS5A 3TG4A 1MT6A 2F69A 4J83A 3MO0A 3M54A 1ML9A 3CBPA
chains in the Genus database with same CATH superfamily
2IGQA 3OXLA 1MUFA 3VUZA 4YNPA 3RU0A 5JHNA 3IHXA 5KJKA 2W5YA 3S8PA 1N3JA 3MO2A 4MI5A 3M58A 5ARFA 4YNDA 4O30A 5TH7A 5TTFA 3HNAA 3TG5A 5F6KC 5EX3A 4RZ0A 3F9WA 4NVQA 3M53A 3M55A 4AU7A 3MEKA 3M59A 4YPAA 4JDSA 4IJDA 3OXGA 3QWPA 4JLGA 2O8JA 4QEPA 3MO5A 5KJMA 5HQ8A 4IJ8A 2G46A 2R3AA 4Z4PA 1N6AA 5HI7A 2JV0A 3M56A 2QPWA 5T0KA 3RIBA 4O6FA 5LSZA 4YNMA 4QENA 3CBMA 3KMJA 3OXFA 1H3IA 3K5KA 3CBOA 4LDGA 5F59A 5CCLA 4YPUA 5T0MA 5CCMA 2W5ZA 3S7BA 4I51A 4J7FA 3QWVA 5AYFA 3BO5A 1MVXA 5EG2A 3S7JA 5ARGA 3FPDA 3N71A 3F9XA 3RJWA 3OPEA 5CPRB 3QWWA 4FMUA 3OOIA 4H12A 5KJNA 4E47A 4WUYA 5EX0A 5KJLA 3F9YA 5T5GA 3S7FA 1XQHA 3VV0A 3KMTA 1PEGA 3RAYA 2BQZA 5JINA 3RQ4A 3DALA 5F5EA 3S7DA 1ZKKA 5F6LA 3KMAA 3EP0A 3PDNA 5JJ0A 4BUPA 2RFIA 4C1QA 3M57A 5TEGA 5LSXA 4YPEA 4NJ5A 1O9SA 1N6CA 3SWCA 3F9ZA 5JIYA 4J8OA 3SW9A 4QEOA 3M5AA 4J7IA 4MI0A 3DB5A 1MVHA 3OS5A 3TG4A 1MT6A 2F69A 4J83A 3MO0A 3M54A 1ML9A 3CBPA
chains in the Genus database with same CATH topology
2IGQA 3OXLA 1MUFA 3VUZA 4YNPA 3RU0A 5JHNA 3IHXA 5KJKA 2W5YA 3S8PA 1N3JA 3MO2A 4MI5A 3M58A 5ARFA 4YNDA 4O30A 5TH7A 5TTFA 3HNAA 3TG5A 5F6KC 5EX3A 4RZ0A 3F9WA 4NVQA 3M53A 3M55A 4AU7A 3MEKA 3M59A 4YPAA 4JDSA 4IJDA 3OXGA 3QWPA 4JLGA 2O8JA 4QEPA 3MO5A 5KJMA 5HQ8A 4IJ8A 2G46A 2R3AA 4Z4PA 1N6AA 5HI7A 2JV0A 3M56A 2QPWA 5T0KA 3RIBA 4O6FA 5LSZA 4YNMA 4QENA 3CBMA 3KMJA 3OXFA 1H3IA 3K5KA 3CBOA 4LDGA 5F59A 5CCLA 4YPUA 5T0MA 5CCMA 2W5ZA 3S7BA 4I51A 4J7FA 3QWVA 5AYFA 3BO5A 1MVXA 5EG2A 3S7JA 5ARGA 3FPDA 3N71A 3F9XA 3RJWA 3OPEA 5CPRB 3QWWA 4FMUA 3OOIA 4H12A 5KJNA 4E47A 4WUYA 5EX0A 5KJLA 3F9YA 5T5GA 3S7FA 1XQHA 3VV0A 3KMTA 1PEGA 3RAYA 2BQZA 5JINA 3RQ4A 3DALA 5F5EA 3S7DA 1ZKKA 5F6LA 3KMAA 3EP0A 3PDNA 5JJ0A 4BUPA 2RFIA 4C1QA 3M57A 5TEGA 5LSXA 4YPEA 4NJ5A 1O9SA 1N6CA 3SWCA 3F9ZA 5JIYA 4J8OA 3SW9A 4QEOA 3M5AA 4J7IA 4MI0A 3DB5A 1MVHA 3OS5A 3TG4A 1MT6A 2F69A 4J83A 3MO0A 3M54A 1ML9A 3CBPA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2IGQ A;  3OXL A;  1MUF A;  3VUZ A;  4YNP A;  3RU0 A;  5JHN A;  3IHX A;  5KJK A;  2W5Y A;  3S8P A;  1N3J A;  3MO2 A;  4MI5 A;  3M58 A;  5ARF A;  4YND A;  4O30 A;  5TH7 A;  5TTF A;  3HNA A;  3TG5 A;  5F6K C;  5EX3 A;  4RZ0 A;  3F9W A;  4NVQ A;  3M53 A;  3M55 A;  4AU7 A;  3MEK A;  3M59 A;  4YPA A;  4JDS A;  4IJD A;  3OXG A;  3QWP A;  4JLG A;  2O8J A;  4QEP A;  3MO5 A;  5KJM A;  5HQ8 A;  4IJ8 A;  2G46 A;  2R3A A;  4Z4P A;  1N6A A;  5HI7 A;  2JV0 A;  3M56 A;  2QPW A;  5T0K A;  3RIB A;  4O6F A;  5LSZ A;  4YNM A;  4QEN A;  3CBM A;  3KMJ A;  3OXF A;  1H3I A;  3K5K A;  3CBO A;  4LDG A;  5F59 A;  5CCL A;  4YPU A;  5T0M A;  5CCM A;  2W5Z A;  3S7B A;  4I51 A;  4J7F A;  3QWV A;  5AYF A;  3BO5 A;  1MVX A;  5EG2 A;  3S7J A;  5ARG A;  3FPD A;  3N71 A;  3F9X A;  3RJW A;  3OPE A;  5CPR B;  3QWW A;  4FMU A;  3OOI A;  4H12 A;  5KJN A;  4E47 A;  4WUY A;  5EX0 A;  5KJL A;  3F9Y A;  5T5G A;  3S7F A;  1XQH A;  3VV0 A;  3KMT A;  1PEG A;  3RAY A;  2BQZ A;  5JIN A;  3RQ4 A;  3DAL A;  5F5E A;  3S7D A;  1ZKK A;  5F6L A;  3KMA A;  3EP0 A;  3PDN A;  5JJ0 A;  4BUP A;  2RFI A;  4C1Q A;  3M57 A;  5TEG A;  5LSX A;  4YPE A;  4NJ5 A;  1O9S A;  1N6C A;  3SWC A;  3F9Z A;  5JIY A;  4J8O A;  3SW9 A;  4QEO A;  3M5A A;  4J7I A;  4MI0 A;  3DB5 A;  1MVH A;  3OS5 A;  3TG4 A;  1MT6 A;  2F69 A;  4J83 A;  3MO0 A;  3M54 A;  1ML9 A;  3CBP A; 
#chains in the Genus database with same CATH topology
 2IGQ A;  3OXL A;  1MUF A;  3VUZ A;  4YNP A;  3RU0 A;  5JHN A;  3IHX A;  5KJK A;  2W5Y A;  3S8P A;  1N3J A;  3MO2 A;  4MI5 A;  3M58 A;  5ARF A;  4YND A;  4O30 A;  5TH7 A;  5TTF A;  3HNA A;  3TG5 A;  5F6K C;  5EX3 A;  4RZ0 A;  3F9W A;  4NVQ A;  3M53 A;  3M55 A;  4AU7 A;  3MEK A;  3M59 A;  4YPA A;  4JDS A;  4IJD A;  3OXG A;  3QWP A;  4JLG A;  2O8J A;  4QEP A;  3MO5 A;  5KJM A;  5HQ8 A;  4IJ8 A;  2G46 A;  2R3A A;  4Z4P A;  1N6A A;  5HI7 A;  2JV0 A;  3M56 A;  2QPW A;  5T0K A;  3RIB A;  4O6F A;  5LSZ A;  4YNM A;  4QEN A;  3CBM A;  3KMJ A;  3OXF A;  1H3I A;  3K5K A;  3CBO A;  4LDG A;  5F59 A;  5CCL A;  4YPU A;  5T0M A;  5CCM A;  2W5Z A;  3S7B A;  4I51 A;  4J7F A;  3QWV A;  5AYF A;  3BO5 A;  1MVX A;  5EG2 A;  3S7J A;  5ARG A;  3FPD A;  3N71 A;  3F9X A;  3RJW A;  3OPE A;  5CPR B;  3QWW A;  4FMU A;  3OOI A;  4H12 A;  5KJN A;  4E47 A;  4WUY A;  5EX0 A;  5KJL A;  3F9Y A;  5T5G A;  3S7F A;  1XQH A;  3VV0 A;  3KMT A;  1PEG A;  3RAY A;  2BQZ A;  5JIN A;  3RQ4 A;  3DAL A;  5F5E A;  3S7D A;  1ZKK A;  5F6L A;  3KMA A;  3EP0 A;  3PDN A;  5JJ0 A;  4BUP A;  2RFI A;  4C1Q A;  3M57 A;  5TEG A;  5LSX A;  4YPE A;  4NJ5 A;  1O9S A;  1N6C A;  3SWC A;  3F9Z A;  5JIY A;  4J8O A;  3SW9 A;  4QEO A;  3M5A A;  4J7I A;  4MI0 A;  3DB5 A;  1MVH A;  3OS5 A;  3TG4 A;  1MT6 A;  2F69 A;  4J83 A;  3MO0 A;  3M54 A;  1ML9 A;  3CBP A; 
#chains in the Genus database with same CATH homology
 2IGQ A;  3OXL A;  1MUF A;  3VUZ A;  4YNP A;  3RU0 A;  5JHN A;  3IHX A;  5KJK A;  2W5Y A;  3S8P A;  1N3J A;  3MO2 A;  4MI5 A;  3M58 A;  5ARF A;  4YND A;  4O30 A;  5TH7 A;  5TTF A;  3HNA A;  3TG5 A;  5F6K C;  5EX3 A;  4RZ0 A;  3F9W A;  4NVQ A;  3M53 A;  3M55 A;  4AU7 A;  3MEK A;  3M59 A;  4YPA A;  4JDS A;  4IJD A;  3OXG A;  3QWP A;  4JLG A;  2O8J A;  4QEP A;  3MO5 A;  5KJM A;  5HQ8 A;  4IJ8 A;  2G46 A;  2R3A A;  4Z4P A;  1N6A A;  5HI7 A;  2JV0 A;  3M56 A;  2QPW A;  5T0K A;  3RIB A;  4O6F A;  5LSZ A;  4YNM A;  4QEN A;  3CBM A;  3KMJ A;  3OXF A;  1H3I A;  3K5K A;  3CBO A;  4LDG A;  5F59 A;  5CCL A;  4YPU A;  5T0M A;  5CCM A;  2W5Z A;  3S7B A;  4I51 A;  4J7F A;  3QWV A;  5AYF A;  3BO5 A;  1MVX A;  5EG2 A;  3S7J A;  5ARG A;  3FPD A;  3N71 A;  3F9X A;  3RJW A;  3OPE A;  5CPR B;  3QWW A;  4FMU A;  3OOI A;  4H12 A;  5KJN A;  4E47 A;  4WUY A;  5EX0 A;  5KJL A;  3F9Y A;  5T5G A;  3S7F A;  1XQH A;  3VV0 A;  3KMT A;  1PEG A;  3RAY A;  2BQZ A;  5JIN A;  3RQ4 A;  3DAL A;  5F5E A;  3S7D A;  1ZKK A;  5F6L A;  3KMA A;  3EP0 A;  3PDN A;  5JJ0 A;  4BUP A;  2RFI A;  4C1Q A;  3M57 A;  5TEG A;  5LSX A;  4YPE A;  4NJ5 A;  1O9S A;  1N6C A;  3SWC A;  3F9Z A;  5JIY A;  4J8O A;  3SW9 A;  4QEO A;  3M5A A;  4J7I A;  4MI0 A;  3DB5 A;  1MVH A;  3OS5 A;  3TG4 A;  1MT6 A;  2F69 A;  4J83 A;  3MO0 A;  3M54 A;  1ML9 A;  3CBP A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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