3RJWA

Crystal structure of histone lysine methyltransferase g9a with an inhibitor
Total Genus 67
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
67
sequence length
270
structure length
268
Chain Sequence
TEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKYFTCQCGSEKCKHSAEAIALEQS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Transferase/transferase inhibitor
molecule keywords Histone-lysine N-methyltransferase EHMT2
total genus 67
structure length 268
sequence length 270
chains with identical sequence B
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2011-04-15

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF05033 Pre-SET Pre-SET motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 3rjwA00
4O6FA 3HNAA 5JHNA 3KMAA 4JDSA 3MEKA 5T0MA 5F5EA 2R3AA 3F9YA 4FMUA 4J8OA 3OXFA 3QWVA 4WUYA 3SWCA 5T0KA 3RQ4A 3DALA 4QEPA 4C1QA 4YPEA 4IJDA 3RAYA 4H12A 2IGQA 5TH7A 3DB5A 3OXGA 3F9XA 3S8PA 4BUPA 2G46A 3TG5A 5EX3A 2F69A 2O8JA 3IHXA 1MVHA 4J7IA 3M5AA 3M56A 3S7JA 4YNMA 5LSXA 3CBMA 3PDNA 4IJ8A 4J7FA 5T5GA 5AYFA 5HI7A 3OS5A 5TEGA 5CPRB 3F9WA 2QPWA 4E47A 3OPEA 5HQ8A 5CCMA 3K5KA 5TTFA 4YNPA 3M57A 3M58A 3M54A 4YPUA 4RZ0A 4MI5A 5KJMA 5F59A 4I51A 5CCLA 3OXLA 4MI0A 1ZKKA 3RU0A 3M55A 3M59A 3N71A 5KJKA 3TG4A 2JV0A 3CBOA 4J83A 3KMJA 4QEOA 3QWWA 4NJ5A 5EX0A 3RIBA 3F9ZA 3FPDA 4O30A 1MVXA 5F6LA 5ARFA 5ARGA 5JINA 4YPAA 1MUFA 3VUZA 3CBPA 4AU7A 3S7BA 3OOIA 3SW9A 1N6CA 5KJNA 5KJLA 1PEGA 3MO2A 3M53A 3MO5A 1N3JA 3QWPA 4NVQA 1N6AA 1MT6A 2RFIA 5JJ0A 3MO0A 2W5ZA 5F6KC 4Z4PA 1XQHA 3KMTA 4QENA 5JIYA 3RJWA 1O9SA 2BQZA 3EP0A 4YNDA 5LSZA 3BO5A 3S7FA 3VV0A 5EG2A 3S7DA 2W5YA 1H3IA 4LDGA 1ML9A 4JLGA
chains in the Genus database with same CATH superfamily
4O6FA 3HNAA 5JHNA 3KMAA 4JDSA 3MEKA 5T0MA 5F5EA 2R3AA 3F9YA 4FMUA 4J8OA 3OXFA 3QWVA 4WUYA 3SWCA 5T0KA 3RQ4A 3DALA 4QEPA 4C1QA 4YPEA 4IJDA 3RAYA 4H12A 2IGQA 5TH7A 3DB5A 3OXGA 3F9XA 3S8PA 4BUPA 2G46A 3TG5A 5EX3A 2F69A 2O8JA 3IHXA 1MVHA 4J7IA 3M5AA 3M56A 3S7JA 4YNMA 5LSXA 3CBMA 3PDNA 4IJ8A 4J7FA 5T5GA 5AYFA 5HI7A 3OS5A 5TEGA 5CPRB 3F9WA 2QPWA 4E47A 3OPEA 5HQ8A 5CCMA 3K5KA 5TTFA 4YNPA 3M57A 3M58A 3M54A 4YPUA 4RZ0A 4MI5A 5KJMA 5F59A 4I51A 5CCLA 3OXLA 4MI0A 1ZKKA 3RU0A 3M55A 3M59A 3N71A 5KJKA 3TG4A 2JV0A 3CBOA 4J83A 3KMJA 4QEOA 3QWWA 4NJ5A 5EX0A 3RIBA 3F9ZA 3FPDA 4O30A 1MVXA 5F6LA 5ARFA 5ARGA 5JINA 4YPAA 1MUFA 3VUZA 3CBPA 4AU7A 3S7BA 3OOIA 3SW9A 1N6CA 5KJNA 5KJLA 1PEGA 3MO2A 3M53A 3MO5A 1N3JA 3QWPA 4NVQA 1N6AA 1MT6A 2RFIA 5JJ0A 3MO0A 2W5ZA 5F6KC 4Z4PA 1XQHA 3KMTA 4QENA 5JIYA 3RJWA 1O9SA 2BQZA 3EP0A 4YNDA 5LSZA 3BO5A 3S7FA 3VV0A 5EG2A 3S7DA 2W5YA 1H3IA 4LDGA 1ML9A 4JLGA
chains in the Genus database with same CATH topology
4O6FA 3HNAA 5JHNA 3KMAA 4JDSA 3MEKA 5T0MA 5F5EA 2R3AA 3F9YA 4FMUA 4J8OA 3OXFA 3QWVA 4WUYA 3SWCA 5T0KA 3RQ4A 3DALA 4QEPA 4C1QA 4YPEA 4IJDA 3RAYA 4H12A 2IGQA 5TH7A 3DB5A 3OXGA 3F9XA 3S8PA 4BUPA 2G46A 3TG5A 5EX3A 2F69A 2O8JA 3IHXA 1MVHA 4J7IA 3M5AA 3M56A 3S7JA 4YNMA 5LSXA 3CBMA 3PDNA 4IJ8A 4J7FA 5T5GA 5AYFA 5HI7A 3OS5A 5TEGA 5CPRB 3F9WA 2QPWA 4E47A 3OPEA 5HQ8A 5CCMA 3K5KA 5TTFA 4YNPA 3M57A 3M58A 3M54A 4YPUA 4RZ0A 4MI5A 5KJMA 5F59A 4I51A 5CCLA 3OXLA 4MI0A 1ZKKA 3RU0A 3M55A 3M59A 3N71A 5KJKA 3TG4A 2JV0A 3CBOA 4J83A 3KMJA 4QEOA 3QWWA 4NJ5A 5EX0A 3RIBA 3F9ZA 3FPDA 4O30A 1MVXA 5F6LA 5ARFA 5ARGA 5JINA 4YPAA 1MUFA 3VUZA 3CBPA 4AU7A 3S7BA 3OOIA 3SW9A 1N6CA 5KJNA 5KJLA 1PEGA 3MO2A 3M53A 3MO5A 1N3JA 3QWPA 4NVQA 1N6AA 1MT6A 2RFIA 5JJ0A 3MO0A 2W5ZA 5F6KC 4Z4PA 1XQHA 3KMTA 4QENA 5JIYA 3RJWA 1O9SA 2BQZA 3EP0A 4YNDA 5LSZA 3BO5A 3S7FA 3VV0A 5EG2A 3S7DA 2W5YA 1H3IA 4LDGA 1ML9A 4JLGA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4O6F A;  3HNA A;  5JHN A;  3KMA A;  4JDS A;  3MEK A;  5T0M A;  5F5E A;  2R3A A;  3F9Y A;  4FMU A;  4J8O A;  3OXF A;  3QWV A;  4WUY A;  3SWC A;  5T0K A;  3RQ4 A;  3DAL A;  4QEP A;  4C1Q A;  4YPE A;  4IJD A;  3RAY A;  4H12 A;  2IGQ A;  5TH7 A;  3DB5 A;  3OXG A;  3F9X A;  3S8P A;  4BUP A;  2G46 A;  3TG5 A;  5EX3 A;  2F69 A;  2O8J A;  3IHX A;  1MVH A;  4J7I A;  3M5A A;  3M56 A;  3S7J A;  4YNM A;  5LSX A;  3CBM A;  3PDN A;  4IJ8 A;  4J7F A;  5T5G A;  5AYF A;  5HI7 A;  3OS5 A;  5TEG A;  5CPR B;  3F9W A;  2QPW A;  4E47 A;  3OPE A;  5HQ8 A;  5CCM A;  3K5K A;  5TTF A;  4YNP A;  3M57 A;  3M58 A;  3M54 A;  4YPU A;  4RZ0 A;  4MI5 A;  5KJM A;  5F59 A;  4I51 A;  5CCL A;  3OXL A;  4MI0 A;  1ZKK A;  3RU0 A;  3M55 A;  3M59 A;  3N71 A;  5KJK A;  3TG4 A;  2JV0 A;  3CBO A;  4J83 A;  3KMJ A;  4QEO A;  3QWW A;  4NJ5 A;  5EX0 A;  3RIB A;  3F9Z A;  3FPD A;  4O30 A;  1MVX A;  5F6L A;  5ARF A;  5ARG A;  5JIN A;  4YPA A;  1MUF A;  3VUZ A;  3CBP A;  4AU7 A;  3S7B A;  3OOI A;  3SW9 A;  1N6C A;  5KJN A;  5KJL A;  1PEG A;  3MO2 A;  3M53 A;  3MO5 A;  1N3J A;  3QWP A;  4NVQ A;  1N6A A;  1MT6 A;  2RFI A;  5JJ0 A;  3MO0 A;  2W5Z A;  5F6K C;  4Z4P A;  1XQH A;  3KMT A;  4QEN A;  5JIY A;  3RJW A;  1O9S A;  2BQZ A;  3EP0 A;  4YND A;  5LSZ A;  3BO5 A;  3S7F A;  3VV0 A;  5EG2 A;  3S7D A;  2W5Y A;  1H3I A;  4LDG A;  1ML9 A;  4JLG A; 
#chains in the Genus database with same CATH topology
 4O6F A;  3HNA A;  5JHN A;  3KMA A;  4JDS A;  3MEK A;  5T0M A;  5F5E A;  2R3A A;  3F9Y A;  4FMU A;  4J8O A;  3OXF A;  3QWV A;  4WUY A;  3SWC A;  5T0K A;  3RQ4 A;  3DAL A;  4QEP A;  4C1Q A;  4YPE A;  4IJD A;  3RAY A;  4H12 A;  2IGQ A;  5TH7 A;  3DB5 A;  3OXG A;  3F9X A;  3S8P A;  4BUP A;  2G46 A;  3TG5 A;  5EX3 A;  2F69 A;  2O8J A;  3IHX A;  1MVH A;  4J7I A;  3M5A A;  3M56 A;  3S7J A;  4YNM A;  5LSX A;  3CBM A;  3PDN A;  4IJ8 A;  4J7F A;  5T5G A;  5AYF A;  5HI7 A;  3OS5 A;  5TEG A;  5CPR B;  3F9W A;  2QPW A;  4E47 A;  3OPE A;  5HQ8 A;  5CCM A;  3K5K A;  5TTF A;  4YNP A;  3M57 A;  3M58 A;  3M54 A;  4YPU A;  4RZ0 A;  4MI5 A;  5KJM A;  5F59 A;  4I51 A;  5CCL A;  3OXL A;  4MI0 A;  1ZKK A;  3RU0 A;  3M55 A;  3M59 A;  3N71 A;  5KJK A;  3TG4 A;  2JV0 A;  3CBO A;  4J83 A;  3KMJ A;  4QEO A;  3QWW A;  4NJ5 A;  5EX0 A;  3RIB A;  3F9Z A;  3FPD A;  4O30 A;  1MVX A;  5F6L A;  5ARF A;  5ARG A;  5JIN A;  4YPA A;  1MUF A;  3VUZ A;  3CBP A;  4AU7 A;  3S7B A;  3OOI A;  3SW9 A;  1N6C A;  5KJN A;  5KJL A;  1PEG A;  3MO2 A;  3M53 A;  3MO5 A;  1N3J A;  3QWP A;  4NVQ A;  1N6A A;  1MT6 A;  2RFI A;  5JJ0 A;  3MO0 A;  2W5Z A;  5F6K C;  4Z4P A;  1XQH A;  3KMT A;  4QEN A;  5JIY A;  3RJW A;  1O9S A;  2BQZ A;  3EP0 A;  4YND A;  5LSZ A;  3BO5 A;  3S7F A;  3VV0 A;  5EG2 A;  3S7D A;  2W5Y A;  1H3I A;  4LDG A;  1ML9 A;  4JLG A; 
#chains in the Genus database with same CATH homology
 4O6F A;  3HNA A;  5JHN A;  3KMA A;  4JDS A;  3MEK A;  5T0M A;  5F5E A;  2R3A A;  3F9Y A;  4FMU A;  4J8O A;  3OXF A;  3QWV A;  4WUY A;  3SWC A;  5T0K A;  3RQ4 A;  3DAL A;  4QEP A;  4C1Q A;  4YPE A;  4IJD A;  3RAY A;  4H12 A;  2IGQ A;  5TH7 A;  3DB5 A;  3OXG A;  3F9X A;  3S8P A;  4BUP A;  2G46 A;  3TG5 A;  5EX3 A;  2F69 A;  2O8J A;  3IHX A;  1MVH A;  4J7I A;  3M5A A;  3M56 A;  3S7J A;  4YNM A;  5LSX A;  3CBM A;  3PDN A;  4IJ8 A;  4J7F A;  5T5G A;  5AYF A;  5HI7 A;  3OS5 A;  5TEG A;  5CPR B;  3F9W A;  2QPW A;  4E47 A;  3OPE A;  5HQ8 A;  5CCM A;  3K5K A;  5TTF A;  4YNP A;  3M57 A;  3M58 A;  3M54 A;  4YPU A;  4RZ0 A;  4MI5 A;  5KJM A;  5F59 A;  4I51 A;  5CCL A;  3OXL A;  4MI0 A;  1ZKK A;  3RU0 A;  3M55 A;  3M59 A;  3N71 A;  5KJK A;  3TG4 A;  2JV0 A;  3CBO A;  4J83 A;  3KMJ A;  4QEO A;  3QWW A;  4NJ5 A;  5EX0 A;  3RIB A;  3F9Z A;  3FPD A;  4O30 A;  1MVX A;  5F6L A;  5ARF A;  5ARG A;  5JIN A;  4YPA A;  1MUF A;  3VUZ A;  3CBP A;  4AU7 A;  3S7B A;  3OOI A;  3SW9 A;  1N6C A;  5KJN A;  5KJL A;  1PEG A;  3MO2 A;  3M53 A;  3MO5 A;  1N3J A;  3QWP A;  4NVQ A;  1N6A A;  1MT6 A;  2RFI A;  5JJ0 A;  3MO0 A;  2W5Z A;  5F6K C;  4Z4P A;  1XQH A;  3KMT A;  4QEN A;  5JIY A;  3RJW A;  1O9S A;  2BQZ A;  3EP0 A;  4YND A;  5LSZ A;  3BO5 A;  3S7F A;  3VV0 A;  5EG2 A;  3S7D A;  2W5Y A;  1H3I A;  4LDG A;  1ML9 A;  4JLG A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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