3RJWA

Crystal structure of histone lysine methyltransferase g9a with an inhibitor
Total Genus 67
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
67
sequence length
270
structure length
268
Chain Sequence
b'TEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKYFTCQCGSEKCKHSAEAIALEQS'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Histone-lysine N-methyltransferase EHMT2
publication title A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Transferase/transferase inhibitor
total genus 67
structure length 268
sequence length 270
chains with identical sequence B
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2011-04-15

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF05033 Pre-SET Pre-SET motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 3rjwA00
3KMAA 3S7DA 3S8PA 4YNMA 4H12A 5F6KC 1N3JA 3MO5A 3S7BA 3IHXA 3F9ZA 3RIBA 3CBPA 4NJ5A 3QWVA 5TTFA 4MI0A 3OXGA 4WUYA 4JDSA 4MI5A 5EG2A 1ML9A 4NVQA 5T0MA 5T0KA 3K5KA 5LSXA 3EP0A 4E47A 3F9XA 4J83A 2QPWA 1ZKKA 3S7FA 3M53A 4IJ8A 5HI7A 4RZ0A 5KJNA 3M55A 3OPEA 5AYFA 5CCLA 5JHNA 5F6LA 5F59A 5HQ8A 2F69A 3OXFA 4LDGA 2JV0A 4QEPA 3BO5A 4J7FA 4YNPA 5CCMA 2O8JA 4J8OA 3M5AA 3M57A 4YPAA 3PDNA 3M54A 3VV0A 5LSZA 3M58A 3MO0A 4QENA 3F9YA 3RAYA 3CBOA 1MVXA 5T5GA 2W5YA 4I51A 3RU0A 1N6CA 1PEGA 1MUFA 3HNAA 4QEOA 3M56A 4YPUA 5EX0A 5JIYA 2RFIA 3TG4A 5ARFA 3OOIA 3KMTA 3OS5A 4O30A 4C1QA 1XQHA 3SW9A 3M59A 4J7IA 3CBMA 5KJMA 3OXLA 3SWCA 4JLGA 3KMJA 4FMUA 4BUPA 4Z4PA 4YNDA 1O9SA 5TH7A 4AU7A 1MVHA 3MEKA 3S7JA 3RJWA 3QWPA 5KJKA 2G46A 2R3AA 2IGQA 5KJLA 3QWWA 5TEGA 5CPRB 3DALA 5ARGA 3FPDA 5F5EA 1H3IA 1N6AA 4O6FA 3RQ4A 4IJDA 5JINA 3DB5A 3VUZA 3N71A 3F9WA 3TG5A 5JJ0A 2BQZA 5EX3A 3MO2A 4YPEA 1MT6A 2W5ZA
chains in the Genus database with same CATH superfamily
3KMAA 3S7DA 3S8PA 4YNMA 4H12A 5F6KC 1N3JA 3MO5A 3S7BA 3IHXA 3F9ZA 3RIBA 3CBPA 4NJ5A 3QWVA 5TTFA 4MI0A 3OXGA 4WUYA 4JDSA 4MI5A 5EG2A 1ML9A 4NVQA 5T0MA 5T0KA 3K5KA 5LSXA 3EP0A 4E47A 3F9XA 4J83A 2QPWA 1ZKKA 3S7FA 3M53A 4IJ8A 5HI7A 4RZ0A 5KJNA 3M55A 3OPEA 5AYFA 5CCLA 5JHNA 5F6LA 5F59A 5HQ8A 2F69A 3OXFA 4LDGA 2JV0A 4QEPA 3BO5A 4J7FA 4YNPA 5CCMA 2O8JA 4J8OA 3M5AA 3M57A 4YPAA 3PDNA 3M54A 3VV0A 5LSZA 3M58A 3MO0A 4QENA 3F9YA 3RAYA 3CBOA 1MVXA 5T5GA 2W5YA 4I51A 3RU0A 1N6CA 1PEGA 1MUFA 3HNAA 4QEOA 3M56A 4YPUA 5EX0A 5JIYA 2RFIA 3TG4A 5ARFA 3OOIA 3KMTA 3OS5A 4O30A 4C1QA 1XQHA 3SW9A 3M59A 4J7IA 3CBMA 5KJMA 3OXLA 3SWCA 4JLGA 3KMJA 4FMUA 4BUPA 4Z4PA 4YNDA 1O9SA 5TH7A 4AU7A 1MVHA 3MEKA 3S7JA 3RJWA 3QWPA 5KJKA 2G46A 2R3AA 2IGQA 5KJLA 3QWWA 5TEGA 5CPRB 3DALA 5ARGA 3FPDA 5F5EA 1H3IA 1N6AA 4O6FA 3RQ4A 4IJDA 5JINA 3DB5A 3VUZA 3N71A 3F9WA 3TG5A 5JJ0A 2BQZA 5EX3A 3MO2A 4YPEA 1MT6A 2W5ZA
chains in the Genus database with same CATH topology
3KMAA 3S7DA 3S8PA 4YNMA 4H12A 5F6KC 1N3JA 3MO5A 3S7BA 3IHXA 3F9ZA 3RIBA 3CBPA 4NJ5A 3QWVA 5TTFA 4MI0A 3OXGA 4WUYA 4JDSA 4MI5A 5EG2A 1ML9A 4NVQA 5T0MA 5T0KA 3K5KA 5LSXA 3EP0A 4E47A 3F9XA 4J83A 2QPWA 1ZKKA 3S7FA 3M53A 4IJ8A 5HI7A 4RZ0A 5KJNA 3M55A 3OPEA 5AYFA 5CCLA 5JHNA 5F6LA 5F59A 5HQ8A 2F69A 3OXFA 4LDGA 2JV0A 4QEPA 3BO5A 4J7FA 4YNPA 5CCMA 2O8JA 4J8OA 3M5AA 3M57A 4YPAA 3PDNA 3M54A 3VV0A 5LSZA 3M58A 3MO0A 4QENA 3F9YA 3RAYA 3CBOA 1MVXA 5T5GA 2W5YA 4I51A 3RU0A 1N6CA 1PEGA 1MUFA 3HNAA 4QEOA 3M56A 4YPUA 5EX0A 5JIYA 2RFIA 3TG4A 5ARFA 3OOIA 3KMTA 3OS5A 4O30A 4C1QA 1XQHA 3SW9A 3M59A 4J7IA 3CBMA 5KJMA 3OXLA 3SWCA 4JLGA 3KMJA 4FMUA 4BUPA 4Z4PA 4YNDA 1O9SA 5TH7A 4AU7A 1MVHA 3MEKA 3S7JA 3RJWA 3QWPA 5KJKA 2G46A 2R3AA 2IGQA 5KJLA 3QWWA 5TEGA 5CPRB 3DALA 5ARGA 3FPDA 5F5EA 1H3IA 1N6AA 4O6FA 3RQ4A 4IJDA 5JINA 3DB5A 3VUZA 3N71A 3F9WA 3TG5A 5JJ0A 2BQZA 5EX3A 3MO2A 4YPEA 1MT6A 2W5ZA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3KMA A;  3S7D A;  3S8P A;  4YNM A;  4H12 A;  5F6K C;  1N3J A;  3MO5 A;  3S7B A;  3IHX A;  3F9Z A;  3RIB A;  3CBP A;  4NJ5 A;  3QWV A;  5TTF A;  4MI0 A;  3OXG A;  4WUY A;  4JDS A;  4MI5 A;  5EG2 A;  1ML9 A;  4NVQ A;  5T0M A;  5T0K A;  3K5K A;  5LSX A;  3EP0 A;  4E47 A;  3F9X A;  4J83 A;  2QPW A;  1ZKK A;  3S7F A;  3M53 A;  4IJ8 A;  5HI7 A;  4RZ0 A;  5KJN A;  3M55 A;  3OPE A;  5AYF A;  5CCL A;  5JHN A;  5F6L A;  5F59 A;  5HQ8 A;  2F69 A;  3OXF A;  4LDG A;  2JV0 A;  4QEP A;  3BO5 A;  4J7F A;  4YNP A;  5CCM A;  2O8J A;  4J8O A;  3M5A A;  3M57 A;  4YPA A;  3PDN A;  3M54 A;  3VV0 A;  5LSZ A;  3M58 A;  3MO0 A;  4QEN A;  3F9Y A;  3RAY A;  3CBO A;  1MVX A;  5T5G A;  2W5Y A;  4I51 A;  3RU0 A;  1N6C A;  1PEG A;  1MUF A;  3HNA A;  4QEO A;  3M56 A;  4YPU A;  5EX0 A;  5JIY A;  2RFI A;  3TG4 A;  5ARF A;  3OOI A;  3KMT A;  3OS5 A;  4O30 A;  4C1Q A;  1XQH A;  3SW9 A;  3M59 A;  4J7I A;  3CBM A;  5KJM A;  3OXL A;  3SWC A;  4JLG A;  3KMJ A;  4FMU A;  4BUP A;  4Z4P A;  4YND A;  1O9S A;  5TH7 A;  4AU7 A;  1MVH A;  3MEK A;  3S7J A;  3RJW A;  3QWP A;  5KJK A;  2G46 A;  2R3A A;  2IGQ A;  5KJL A;  3QWW A;  5TEG A;  5CPR B;  3DAL A;  5ARG A;  3FPD A;  5F5E A;  1H3I A;  1N6A A;  4O6F A;  3RQ4 A;  4IJD A;  5JIN A;  3DB5 A;  3VUZ A;  3N71 A;  3F9W A;  3TG5 A;  5JJ0 A;  2BQZ A;  5EX3 A;  3MO2 A;  4YPE A;  1MT6 A;  2W5Z A; 
#chains in the Genus database with same CATH topology
 3KMA A;  3S7D A;  3S8P A;  4YNM A;  4H12 A;  5F6K C;  1N3J A;  3MO5 A;  3S7B A;  3IHX A;  3F9Z A;  3RIB A;  3CBP A;  4NJ5 A;  3QWV A;  5TTF A;  4MI0 A;  3OXG A;  4WUY A;  4JDS A;  4MI5 A;  5EG2 A;  1ML9 A;  4NVQ A;  5T0M A;  5T0K A;  3K5K A;  5LSX A;  3EP0 A;  4E47 A;  3F9X A;  4J83 A;  2QPW A;  1ZKK A;  3S7F A;  3M53 A;  4IJ8 A;  5HI7 A;  4RZ0 A;  5KJN A;  3M55 A;  3OPE A;  5AYF A;  5CCL A;  5JHN A;  5F6L A;  5F59 A;  5HQ8 A;  2F69 A;  3OXF A;  4LDG A;  2JV0 A;  4QEP A;  3BO5 A;  4J7F A;  4YNP A;  5CCM A;  2O8J A;  4J8O A;  3M5A A;  3M57 A;  4YPA A;  3PDN A;  3M54 A;  3VV0 A;  5LSZ A;  3M58 A;  3MO0 A;  4QEN A;  3F9Y A;  3RAY A;  3CBO A;  1MVX A;  5T5G A;  2W5Y A;  4I51 A;  3RU0 A;  1N6C A;  1PEG A;  1MUF A;  3HNA A;  4QEO A;  3M56 A;  4YPU A;  5EX0 A;  5JIY A;  2RFI A;  3TG4 A;  5ARF A;  3OOI A;  3KMT A;  3OS5 A;  4O30 A;  4C1Q A;  1XQH A;  3SW9 A;  3M59 A;  4J7I A;  3CBM A;  5KJM A;  3OXL A;  3SWC A;  4JLG A;  3KMJ A;  4FMU A;  4BUP A;  4Z4P A;  4YND A;  1O9S A;  5TH7 A;  4AU7 A;  1MVH A;  3MEK A;  3S7J A;  3RJW A;  3QWP A;  5KJK A;  2G46 A;  2R3A A;  2IGQ A;  5KJL A;  3QWW A;  5TEG A;  5CPR B;  3DAL A;  5ARG A;  3FPD A;  5F5E A;  1H3I A;  1N6A A;  4O6F A;  3RQ4 A;  4IJD A;  5JIN A;  3DB5 A;  3VUZ A;  3N71 A;  3F9W A;  3TG5 A;  5JJ0 A;  2BQZ A;  5EX3 A;  3MO2 A;  4YPE A;  1MT6 A;  2W5Z A; 
#chains in the Genus database with same CATH homology
 3KMA A;  3S7D A;  3S8P A;  4YNM A;  4H12 A;  5F6K C;  1N3J A;  3MO5 A;  3S7B A;  3IHX A;  3F9Z A;  3RIB A;  3CBP A;  4NJ5 A;  3QWV A;  5TTF A;  4MI0 A;  3OXG A;  4WUY A;  4JDS A;  4MI5 A;  5EG2 A;  1ML9 A;  4NVQ A;  5T0M A;  5T0K A;  3K5K A;  5LSX A;  3EP0 A;  4E47 A;  3F9X A;  4J83 A;  2QPW A;  1ZKK A;  3S7F A;  3M53 A;  4IJ8 A;  5HI7 A;  4RZ0 A;  5KJN A;  3M55 A;  3OPE A;  5AYF A;  5CCL A;  5JHN A;  5F6L A;  5F59 A;  5HQ8 A;  2F69 A;  3OXF A;  4LDG A;  2JV0 A;  4QEP A;  3BO5 A;  4J7F A;  4YNP A;  5CCM A;  2O8J A;  4J8O A;  3M5A A;  3M57 A;  4YPA A;  3PDN A;  3M54 A;  3VV0 A;  5LSZ A;  3M58 A;  3MO0 A;  4QEN A;  3F9Y A;  3RAY A;  3CBO A;  1MVX A;  5T5G A;  2W5Y A;  4I51 A;  3RU0 A;  1N6C A;  1PEG A;  1MUF A;  3HNA A;  4QEO A;  3M56 A;  4YPU A;  5EX0 A;  5JIY A;  2RFI A;  3TG4 A;  5ARF A;  3OOI A;  3KMT A;  3OS5 A;  4O30 A;  4C1Q A;  1XQH A;  3SW9 A;  3M59 A;  4J7I A;  3CBM A;  5KJM A;  3OXL A;  3SWC A;  4JLG A;  3KMJ A;  4FMU A;  4BUP A;  4Z4P A;  4YND A;  1O9S A;  5TH7 A;  4AU7 A;  1MVH A;  3MEK A;  3S7J A;  3RJW A;  3QWP A;  5KJK A;  2G46 A;  2R3A A;  2IGQ A;  5KJL A;  3QWW A;  5TEG A;  5CPR B;  3DAL A;  5ARG A;  3FPD A;  5F5E A;  1H3I A;  1N6A A;  4O6F A;  3RQ4 A;  4IJD A;  5JIN A;  3DB5 A;  3VUZ A;  3N71 A;  3F9W A;  3TG5 A;  5JJ0 A;  2BQZ A;  5EX3 A;  3MO2 A;  4YPE A;  1MT6 A;  2W5Z A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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