3RJWA

Crystal structure of histone lysine methyltransferase g9a with an inhibitor
Total Genus 67
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
67
sequence length
270
structure length
268
Chain Sequence
TEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKYFTCQCGSEKCKHSAEAIALEQS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Transferase/transferase inhibitor
molecule keywords Histone-lysine N-methyltransferase EHMT2
total genus 67
structure length 268
sequence length 270
chains with identical sequence B
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2011-04-15

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF05033 Pre-SET Pre-SET motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 3rjwA00
5KJMA 5ARFA 3MO0A 4IJDA 1N6AA 3VUZA 1XQHA 4J7IA 2W5ZA 4WUYA 1PEGA 4LDGA 3F9YA 1H3IA 4Z4PA 3OXLA 5JIYA 3S7BA 4NJ5A 1MVXA 3RU0A 3VV0A 3M55A 4I51A 5T5GA 3CBPA 3S7FA 3F9ZA 5F6LA 5T0MA 5KJKA 3RIBA 1MT6A 5CPRB 5EX0A 1O9SA 3EP0A 3CBOA 3BO5A 4JLGA 3M54A 4JDSA 5LSZA 5HI7A 3M53A 3OXGA 1N3JA 4AU7A 3DALA 3SW9A 3M56A 4J83A 5EX3A 5CCLA 5HQ8A 4YNMA 3OXFA 2QPWA 4YNDA 5F6KC 1MVHA 5CCMA 4YPEA 3KMAA 3TG4A 5T0KA 2IGQA 4H12A 4RZ0A 1ZKKA 5TEGA 4YPUA 3MO5A 4NVQA 5JJ0A 1MUFA 2O8JA 1ML9A 3S7JA 2W5YA 3FPDA 3F9XA 4E47A 4IJ8A 4BUPA 3K5KA 3RJWA 5EG2A 2R3AA 4QEPA 3M59A 2JV0A 1N6CA 3OOIA 3IHXA 5JINA 3M5AA 3OS5A 4J8OA 2RFIA 4MI0A 4O30A 3MO2A 5KJNA 3QWWA 3SWCA 3QWVA 3MEKA 5F59A 3KMTA 3QWPA 4FMUA 5TTFA 5TH7A 3TG5A 2F69A 3OPEA 4MI5A 4YPAA 4C1QA 3KMJA 3S8PA 4YNPA 4O6FA 3F9WA 3CBMA 4QEOA 3RQ4A 5JHNA 2G46A 3RAYA 5KJLA 5AYFA 3DB5A 3N71A 5LSXA 3M58A 3M57A 5ARGA 3PDNA 3S7DA 4QENA 4J7FA 3HNAA 2BQZA 5F5EA
chains in the Genus database with same CATH superfamily
5KJMA 5ARFA 3MO0A 4IJDA 1N6AA 3VUZA 1XQHA 4J7IA 2W5ZA 4WUYA 1PEGA 4LDGA 3F9YA 1H3IA 4Z4PA 3OXLA 5JIYA 3S7BA 4NJ5A 1MVXA 3RU0A 3VV0A 3M55A 4I51A 5T5GA 3CBPA 3S7FA 3F9ZA 5F6LA 5T0MA 5KJKA 3RIBA 1MT6A 5CPRB 5EX0A 1O9SA 3EP0A 3CBOA 3BO5A 4JLGA 3M54A 4JDSA 5LSZA 5HI7A 3M53A 3OXGA 1N3JA 4AU7A 3DALA 3SW9A 3M56A 4J83A 5EX3A 5CCLA 5HQ8A 4YNMA 3OXFA 2QPWA 4YNDA 5F6KC 1MVHA 5CCMA 4YPEA 3KMAA 3TG4A 5T0KA 2IGQA 4H12A 4RZ0A 1ZKKA 5TEGA 4YPUA 3MO5A 4NVQA 5JJ0A 1MUFA 2O8JA 1ML9A 3S7JA 2W5YA 3FPDA 3F9XA 4E47A 4IJ8A 4BUPA 3K5KA 3RJWA 5EG2A 2R3AA 4QEPA 3M59A 2JV0A 1N6CA 3OOIA 3IHXA 5JINA 3M5AA 3OS5A 4J8OA 2RFIA 4MI0A 4O30A 3MO2A 5KJNA 3QWWA 3SWCA 3QWVA 3MEKA 5F59A 3KMTA 3QWPA 4FMUA 5TTFA 5TH7A 3TG5A 2F69A 3OPEA 4MI5A 4YPAA 4C1QA 3KMJA 3S8PA 4YNPA 4O6FA 3F9WA 3CBMA 4QEOA 3RQ4A 5JHNA 2G46A 3RAYA 5KJLA 5AYFA 3DB5A 3N71A 5LSXA 3M58A 3M57A 5ARGA 3PDNA 3S7DA 4QENA 4J7FA 3HNAA 2BQZA 5F5EA
chains in the Genus database with same CATH topology
5KJMA 5ARFA 3MO0A 4IJDA 1N6AA 3VUZA 1XQHA 4J7IA 2W5ZA 4WUYA 1PEGA 4LDGA 3F9YA 1H3IA 4Z4PA 3OXLA 5JIYA 3S7BA 4NJ5A 1MVXA 3RU0A 3VV0A 3M55A 4I51A 5T5GA 3CBPA 3S7FA 3F9ZA 5F6LA 5T0MA 5KJKA 3RIBA 1MT6A 5CPRB 5EX0A 1O9SA 3EP0A 3CBOA 3BO5A 4JLGA 3M54A 4JDSA 5LSZA 5HI7A 3M53A 3OXGA 1N3JA 4AU7A 3DALA 3SW9A 3M56A 4J83A 5EX3A 5CCLA 5HQ8A 4YNMA 3OXFA 2QPWA 4YNDA 5F6KC 1MVHA 5CCMA 4YPEA 3KMAA 3TG4A 5T0KA 2IGQA 4H12A 4RZ0A 1ZKKA 5TEGA 4YPUA 3MO5A 4NVQA 5JJ0A 1MUFA 2O8JA 1ML9A 3S7JA 2W5YA 3FPDA 3F9XA 4E47A 4IJ8A 4BUPA 3K5KA 3RJWA 5EG2A 2R3AA 4QEPA 3M59A 2JV0A 1N6CA 3OOIA 3IHXA 5JINA 3M5AA 3OS5A 4J8OA 2RFIA 4MI0A 4O30A 3MO2A 5KJNA 3QWWA 3SWCA 3QWVA 3MEKA 5F59A 3KMTA 3QWPA 4FMUA 5TTFA 5TH7A 3TG5A 2F69A 3OPEA 4MI5A 4YPAA 4C1QA 3KMJA 3S8PA 4YNPA 4O6FA 3F9WA 3CBMA 4QEOA 3RQ4A 5JHNA 2G46A 3RAYA 5KJLA 5AYFA 3DB5A 3N71A 5LSXA 3M58A 3M57A 5ARGA 3PDNA 3S7DA 4QENA 4J7FA 3HNAA 2BQZA 5F5EA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5KJM A;  5ARF A;  3MO0 A;  4IJD A;  1N6A A;  3VUZ A;  1XQH A;  4J7I A;  2W5Z A;  4WUY A;  1PEG A;  4LDG A;  3F9Y A;  1H3I A;  4Z4P A;  3OXL A;  5JIY A;  3S7B A;  4NJ5 A;  1MVX A;  3RU0 A;  3VV0 A;  3M55 A;  4I51 A;  5T5G A;  3CBP A;  3S7F A;  3F9Z A;  5F6L A;  5T0M A;  5KJK A;  3RIB A;  1MT6 A;  5CPR B;  5EX0 A;  1O9S A;  3EP0 A;  3CBO A;  3BO5 A;  4JLG A;  3M54 A;  4JDS A;  5LSZ A;  5HI7 A;  3M53 A;  3OXG A;  1N3J A;  4AU7 A;  3DAL A;  3SW9 A;  3M56 A;  4J83 A;  5EX3 A;  5CCL A;  5HQ8 A;  4YNM A;  3OXF A;  2QPW A;  4YND A;  5F6K C;  1MVH A;  5CCM A;  4YPE A;  3KMA A;  3TG4 A;  5T0K A;  2IGQ A;  4H12 A;  4RZ0 A;  1ZKK A;  5TEG A;  4YPU A;  3MO5 A;  4NVQ A;  5JJ0 A;  1MUF A;  2O8J A;  1ML9 A;  3S7J A;  2W5Y A;  3FPD A;  3F9X A;  4E47 A;  4IJ8 A;  4BUP A;  3K5K A;  3RJW A;  5EG2 A;  2R3A A;  4QEP A;  3M59 A;  2JV0 A;  1N6C A;  3OOI A;  3IHX A;  5JIN A;  3M5A A;  3OS5 A;  4J8O A;  2RFI A;  4MI0 A;  4O30 A;  3MO2 A;  5KJN A;  3QWW A;  3SWC A;  3QWV A;  3MEK A;  5F59 A;  3KMT A;  3QWP A;  4FMU A;  5TTF A;  5TH7 A;  3TG5 A;  2F69 A;  3OPE A;  4MI5 A;  4YPA A;  4C1Q A;  3KMJ A;  3S8P A;  4YNP A;  4O6F A;  3F9W A;  3CBM A;  4QEO A;  3RQ4 A;  5JHN A;  2G46 A;  3RAY A;  5KJL A;  5AYF A;  3DB5 A;  3N71 A;  5LSX A;  3M58 A;  3M57 A;  5ARG A;  3PDN A;  3S7D A;  4QEN A;  4J7F A;  3HNA A;  2BQZ A;  5F5E A; 
#chains in the Genus database with same CATH topology
 5KJM A;  5ARF A;  3MO0 A;  4IJD A;  1N6A A;  3VUZ A;  1XQH A;  4J7I A;  2W5Z A;  4WUY A;  1PEG A;  4LDG A;  3F9Y A;  1H3I A;  4Z4P A;  3OXL A;  5JIY A;  3S7B A;  4NJ5 A;  1MVX A;  3RU0 A;  3VV0 A;  3M55 A;  4I51 A;  5T5G A;  3CBP A;  3S7F A;  3F9Z A;  5F6L A;  5T0M A;  5KJK A;  3RIB A;  1MT6 A;  5CPR B;  5EX0 A;  1O9S A;  3EP0 A;  3CBO A;  3BO5 A;  4JLG A;  3M54 A;  4JDS A;  5LSZ A;  5HI7 A;  3M53 A;  3OXG A;  1N3J A;  4AU7 A;  3DAL A;  3SW9 A;  3M56 A;  4J83 A;  5EX3 A;  5CCL A;  5HQ8 A;  4YNM A;  3OXF A;  2QPW A;  4YND A;  5F6K C;  1MVH A;  5CCM A;  4YPE A;  3KMA A;  3TG4 A;  5T0K A;  2IGQ A;  4H12 A;  4RZ0 A;  1ZKK A;  5TEG A;  4YPU A;  3MO5 A;  4NVQ A;  5JJ0 A;  1MUF A;  2O8J A;  1ML9 A;  3S7J A;  2W5Y A;  3FPD A;  3F9X A;  4E47 A;  4IJ8 A;  4BUP A;  3K5K A;  3RJW A;  5EG2 A;  2R3A A;  4QEP A;  3M59 A;  2JV0 A;  1N6C A;  3OOI A;  3IHX A;  5JIN A;  3M5A A;  3OS5 A;  4J8O A;  2RFI A;  4MI0 A;  4O30 A;  3MO2 A;  5KJN A;  3QWW A;  3SWC A;  3QWV A;  3MEK A;  5F59 A;  3KMT A;  3QWP A;  4FMU A;  5TTF A;  5TH7 A;  3TG5 A;  2F69 A;  3OPE A;  4MI5 A;  4YPA A;  4C1Q A;  3KMJ A;  3S8P A;  4YNP A;  4O6F A;  3F9W A;  3CBM A;  4QEO A;  3RQ4 A;  5JHN A;  2G46 A;  3RAY A;  5KJL A;  5AYF A;  3DB5 A;  3N71 A;  5LSX A;  3M58 A;  3M57 A;  5ARG A;  3PDN A;  3S7D A;  4QEN A;  4J7F A;  3HNA A;  2BQZ A;  5F5E A; 
#chains in the Genus database with same CATH homology
 5KJM A;  5ARF A;  3MO0 A;  4IJD A;  1N6A A;  3VUZ A;  1XQH A;  4J7I A;  2W5Z A;  4WUY A;  1PEG A;  4LDG A;  3F9Y A;  1H3I A;  4Z4P A;  3OXL A;  5JIY A;  3S7B A;  4NJ5 A;  1MVX A;  3RU0 A;  3VV0 A;  3M55 A;  4I51 A;  5T5G A;  3CBP A;  3S7F A;  3F9Z A;  5F6L A;  5T0M A;  5KJK A;  3RIB A;  1MT6 A;  5CPR B;  5EX0 A;  1O9S A;  3EP0 A;  3CBO A;  3BO5 A;  4JLG A;  3M54 A;  4JDS A;  5LSZ A;  5HI7 A;  3M53 A;  3OXG A;  1N3J A;  4AU7 A;  3DAL A;  3SW9 A;  3M56 A;  4J83 A;  5EX3 A;  5CCL A;  5HQ8 A;  4YNM A;  3OXF A;  2QPW A;  4YND A;  5F6K C;  1MVH A;  5CCM A;  4YPE A;  3KMA A;  3TG4 A;  5T0K A;  2IGQ A;  4H12 A;  4RZ0 A;  1ZKK A;  5TEG A;  4YPU A;  3MO5 A;  4NVQ A;  5JJ0 A;  1MUF A;  2O8J A;  1ML9 A;  3S7J A;  2W5Y A;  3FPD A;  3F9X A;  4E47 A;  4IJ8 A;  4BUP A;  3K5K A;  3RJW A;  5EG2 A;  2R3A A;  4QEP A;  3M59 A;  2JV0 A;  1N6C A;  3OOI A;  3IHX A;  5JIN A;  3M5A A;  3OS5 A;  4J8O A;  2RFI A;  4MI0 A;  4O30 A;  3MO2 A;  5KJN A;  3QWW A;  3SWC A;  3QWV A;  3MEK A;  5F59 A;  3KMT A;  3QWP A;  4FMU A;  5TTF A;  5TH7 A;  3TG5 A;  2F69 A;  3OPE A;  4MI5 A;  4YPA A;  4C1Q A;  3KMJ A;  3S8P A;  4YNP A;  4O6F A;  3F9W A;  3CBM A;  4QEO A;  3RQ4 A;  5JHN A;  2G46 A;  3RAY A;  5KJL A;  5AYF A;  3DB5 A;  3N71 A;  5LSX A;  3M58 A;  3M57 A;  5ARG A;  3PDN A;  3S7D A;  4QEN A;  4J7F A;  3HNA A;  2BQZ A;  5F5E A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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