1ZKKA

Crystal structure of hset8 in ternary complex with h4 peptide (16-24) and adohcy
Total Genus 46
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
46
sequence length
160
structure length
160
Chain Sequence
KSKAELQSEERKRIDELIESGKEEGMKIDLIDGKGRGVIATKQFSRGDFVVEYHGDLIEITDAKKREALYAQDPSTGCYMYYFQYLSKTYCVDATRETNRLGRLINHSKCGNCQTKLHDIDGVPHLILIASRDIAAGEELLYDYGDRSKASIEAHPWLKH
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural and functional analysis of SET8, a histone H4 Lys-20 methyltransferase
pubmed doi rcsb
molecule tags Transferase
source organism Homo sapiens
molecule keywords Histone-lysine N-methyltransferase, H4 lysine-20 specific
total genus 46
structure length 160
sequence length 160
chains with identical sequence B, C, D
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2005-05-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 1zkkA00
3MEKA 3RJWA 3M53A 3N71A 4Z4PA 1XQHA 3MO2A 5F59A 4YPAA 5AYFA 5F6KC 3MO5A 1MT6A 3OXGA 1N6AA 3M5AA 5JIYA 4YPUA 4YNMA 3S7BA 3M56A 3S7JA 5TH7A 5KJLA 5HQ8A 2QPWA 3TG4A 1MUFA 4YPEA 2JV0A 5HI7A 5TTFA 4NVQA 5F5EA 1N6CA 2BQZA 3F9YA 4C1QA 5CPRB 5EX0A 5KJKA 3RU0A 3TG5A 3F9XA 3MO0A 4NJ5A 3EP0A 3S8PA 3KMAA 3KMJA 5LSXA 4E47A 2F69A 5TEGA 3KMTA 4IJ8A 4QEOA 3HNAA 3K5KA 2R3AA 3M58A 3OS5A 3M59A 4WUYA 4H12A 3BO5A 3DB5A 5JINA 3QWPA 1H3IA 3PDNA 5CCMA 3FPDA 3RAYA 3SW9A 4AU7A 5KJNA 4RZ0A 4YNDA 3VV0A 3S7DA 4O30A 5JHNA 1ML9A 3QWVA 3OXFA 3VUZA 5T5GA 2G46A 4QENA 3M57A 1O9SA 3M55A 3CBOA 3OPEA 4J7FA 5KJMA 3IHXA 4J83A 1PEGA 5EG2A 5ARGA 5JJ0A 4J7IA 5EX3A 4JDSA 3F9WA 5F6LA 3RIBA 1MVHA 3QWWA 5T0KA 3OOIA 1MVXA 3DALA 3OXLA 5ARFA 4J8OA 5CCLA 3F9ZA 5LSZA 3S7FA 1ZKKA 3CBPA 4YNPA 4FMUA 2W5YA 4JLGA 2RFIA 4MI5A 3RQ4A 3SWCA 4LDGA 4QEPA 4MI0A 3M54A 4O6FA 1N3JA 2IGQA 2W5ZA 4BUPA 4IJDA 2O8JA 5T0MA 4I51A 3CBMA
chains in the Genus database with same CATH superfamily
3MEKA 3RJWA 3M53A 3N71A 4Z4PA 1XQHA 3MO2A 5F59A 4YPAA 5AYFA 5F6KC 3MO5A 1MT6A 3OXGA 1N6AA 3M5AA 5JIYA 4YPUA 4YNMA 3S7BA 3M56A 3S7JA 5TH7A 5KJLA 5HQ8A 2QPWA 3TG4A 1MUFA 4YPEA 2JV0A 5HI7A 5TTFA 4NVQA 5F5EA 1N6CA 2BQZA 3F9YA 4C1QA 5CPRB 5EX0A 5KJKA 3RU0A 3TG5A 3F9XA 3MO0A 4NJ5A 3EP0A 3S8PA 3KMAA 3KMJA 5LSXA 4E47A 2F69A 5TEGA 3KMTA 4IJ8A 4QEOA 3HNAA 3K5KA 2R3AA 3M58A 3OS5A 3M59A 4WUYA 4H12A 3BO5A 3DB5A 5JINA 3QWPA 1H3IA 3PDNA 5CCMA 3FPDA 3RAYA 3SW9A 4AU7A 5KJNA 4RZ0A 4YNDA 3VV0A 3S7DA 4O30A 5JHNA 1ML9A 3QWVA 3OXFA 3VUZA 5T5GA 2G46A 4QENA 3M57A 1O9SA 3M55A 3CBOA 3OPEA 4J7FA 5KJMA 3IHXA 4J83A 1PEGA 5EG2A 5ARGA 5JJ0A 4J7IA 5EX3A 4JDSA 3F9WA 5F6LA 3RIBA 1MVHA 3QWWA 5T0KA 3OOIA 1MVXA 3DALA 3OXLA 5ARFA 4J8OA 5CCLA 3F9ZA 5LSZA 3S7FA 1ZKKA 3CBPA 4YNPA 4FMUA 2W5YA 4JLGA 2RFIA 4MI5A 3RQ4A 3SWCA 4LDGA 4QEPA 4MI0A 3M54A 4O6FA 1N3JA 2IGQA 2W5ZA 4BUPA 4IJDA 2O8JA 5T0MA 4I51A 3CBMA
chains in the Genus database with same CATH topology
3MEKA 3RJWA 3M53A 3N71A 4Z4PA 1XQHA 3MO2A 5F59A 4YPAA 5AYFA 5F6KC 3MO5A 1MT6A 3OXGA 1N6AA 3M5AA 5JIYA 4YPUA 4YNMA 3S7BA 3M56A 3S7JA 5TH7A 5KJLA 5HQ8A 2QPWA 3TG4A 1MUFA 4YPEA 2JV0A 5HI7A 5TTFA 4NVQA 5F5EA 1N6CA 2BQZA 3F9YA 4C1QA 5CPRB 5EX0A 5KJKA 3RU0A 3TG5A 3F9XA 3MO0A 4NJ5A 3EP0A 3S8PA 3KMAA 3KMJA 5LSXA 4E47A 2F69A 5TEGA 3KMTA 4IJ8A 4QEOA 3HNAA 3K5KA 2R3AA 3M58A 3OS5A 3M59A 4WUYA 4H12A 3BO5A 3DB5A 5JINA 3QWPA 1H3IA 3PDNA 5CCMA 3FPDA 3RAYA 3SW9A 4AU7A 5KJNA 4RZ0A 4YNDA 3VV0A 3S7DA 4O30A 5JHNA 1ML9A 3QWVA 3OXFA 3VUZA 5T5GA 2G46A 4QENA 3M57A 1O9SA 3M55A 3CBOA 3OPEA 4J7FA 5KJMA 3IHXA 4J83A 1PEGA 5EG2A 5ARGA 5JJ0A 4J7IA 5EX3A 4JDSA 3F9WA 5F6LA 3RIBA 1MVHA 3QWWA 5T0KA 3OOIA 1MVXA 3DALA 3OXLA 5ARFA 4J8OA 5CCLA 3F9ZA 5LSZA 3S7FA 1ZKKA 3CBPA 4YNPA 4FMUA 2W5YA 4JLGA 2RFIA 4MI5A 3RQ4A 3SWCA 4LDGA 4QEPA 4MI0A 3M54A 4O6FA 1N3JA 2IGQA 2W5ZA 4BUPA 4IJDA 2O8JA 5T0MA 4I51A 3CBMA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3MEK A;  3RJW A;  3M53 A;  3N71 A;  4Z4P A;  1XQH A;  3MO2 A;  5F59 A;  4YPA A;  5AYF A;  5F6K C;  3MO5 A;  1MT6 A;  3OXG A;  1N6A A;  3M5A A;  5JIY A;  4YPU A;  4YNM A;  3S7B A;  3M56 A;  3S7J A;  5TH7 A;  5KJL A;  5HQ8 A;  2QPW A;  3TG4 A;  1MUF A;  4YPE A;  2JV0 A;  5HI7 A;  5TTF A;  4NVQ A;  5F5E A;  1N6C A;  2BQZ A;  3F9Y A;  4C1Q A;  5CPR B;  5EX0 A;  5KJK A;  3RU0 A;  3TG5 A;  3F9X A;  3MO0 A;  4NJ5 A;  3EP0 A;  3S8P A;  3KMA A;  3KMJ A;  5LSX A;  4E47 A;  2F69 A;  5TEG A;  3KMT A;  4IJ8 A;  4QEO A;  3HNA A;  3K5K A;  2R3A A;  3M58 A;  3OS5 A;  3M59 A;  4WUY A;  4H12 A;  3BO5 A;  3DB5 A;  5JIN A;  3QWP A;  1H3I A;  3PDN A;  5CCM A;  3FPD A;  3RAY A;  3SW9 A;  4AU7 A;  5KJN A;  4RZ0 A;  4YND A;  3VV0 A;  3S7D A;  4O30 A;  5JHN A;  1ML9 A;  3QWV A;  3OXF A;  3VUZ A;  5T5G A;  2G46 A;  4QEN A;  3M57 A;  1O9S A;  3M55 A;  3CBO A;  3OPE A;  4J7F A;  5KJM A;  3IHX A;  4J83 A;  1PEG A;  5EG2 A;  5ARG A;  5JJ0 A;  4J7I A;  5EX3 A;  4JDS A;  3F9W A;  5F6L A;  3RIB A;  1MVH A;  3QWW A;  5T0K A;  3OOI A;  1MVX A;  3DAL A;  3OXL A;  5ARF A;  4J8O A;  5CCL A;  3F9Z A;  5LSZ A;  3S7F A;  1ZKK A;  3CBP A;  4YNP A;  4FMU A;  2W5Y A;  4JLG A;  2RFI A;  4MI5 A;  3RQ4 A;  3SWC A;  4LDG A;  4QEP A;  4MI0 A;  3M54 A;  4O6F A;  1N3J A;  2IGQ A;  2W5Z A;  4BUP A;  4IJD A;  2O8J A;  5T0M A;  4I51 A;  3CBM A; 
#chains in the Genus database with same CATH topology
 3MEK A;  3RJW A;  3M53 A;  3N71 A;  4Z4P A;  1XQH A;  3MO2 A;  5F59 A;  4YPA A;  5AYF A;  5F6K C;  3MO5 A;  1MT6 A;  3OXG A;  1N6A A;  3M5A A;  5JIY A;  4YPU A;  4YNM A;  3S7B A;  3M56 A;  3S7J A;  5TH7 A;  5KJL A;  5HQ8 A;  2QPW A;  3TG4 A;  1MUF A;  4YPE A;  2JV0 A;  5HI7 A;  5TTF A;  4NVQ A;  5F5E A;  1N6C A;  2BQZ A;  3F9Y A;  4C1Q A;  5CPR B;  5EX0 A;  5KJK A;  3RU0 A;  3TG5 A;  3F9X A;  3MO0 A;  4NJ5 A;  3EP0 A;  3S8P A;  3KMA A;  3KMJ A;  5LSX A;  4E47 A;  2F69 A;  5TEG A;  3KMT A;  4IJ8 A;  4QEO A;  3HNA A;  3K5K A;  2R3A A;  3M58 A;  3OS5 A;  3M59 A;  4WUY A;  4H12 A;  3BO5 A;  3DB5 A;  5JIN A;  3QWP A;  1H3I A;  3PDN A;  5CCM A;  3FPD A;  3RAY A;  3SW9 A;  4AU7 A;  5KJN A;  4RZ0 A;  4YND A;  3VV0 A;  3S7D A;  4O30 A;  5JHN A;  1ML9 A;  3QWV A;  3OXF A;  3VUZ A;  5T5G A;  2G46 A;  4QEN A;  3M57 A;  1O9S A;  3M55 A;  3CBO A;  3OPE A;  4J7F A;  5KJM A;  3IHX A;  4J83 A;  1PEG A;  5EG2 A;  5ARG A;  5JJ0 A;  4J7I A;  5EX3 A;  4JDS A;  3F9W A;  5F6L A;  3RIB A;  1MVH A;  3QWW A;  5T0K A;  3OOI A;  1MVX A;  3DAL A;  3OXL A;  5ARF A;  4J8O A;  5CCL A;  3F9Z A;  5LSZ A;  3S7F A;  1ZKK A;  3CBP A;  4YNP A;  4FMU A;  2W5Y A;  4JLG A;  2RFI A;  4MI5 A;  3RQ4 A;  3SWC A;  4LDG A;  4QEP A;  4MI0 A;  3M54 A;  4O6F A;  1N3J A;  2IGQ A;  2W5Z A;  4BUP A;  4IJD A;  2O8J A;  5T0M A;  4I51 A;  3CBM A; 
#chains in the Genus database with same CATH homology
 3MEK A;  3RJW A;  3M53 A;  3N71 A;  4Z4P A;  1XQH A;  3MO2 A;  5F59 A;  4YPA A;  5AYF A;  5F6K C;  3MO5 A;  1MT6 A;  3OXG A;  1N6A A;  3M5A A;  5JIY A;  4YPU A;  4YNM A;  3S7B A;  3M56 A;  3S7J A;  5TH7 A;  5KJL A;  5HQ8 A;  2QPW A;  3TG4 A;  1MUF A;  4YPE A;  2JV0 A;  5HI7 A;  5TTF A;  4NVQ A;  5F5E A;  1N6C A;  2BQZ A;  3F9Y A;  4C1Q A;  5CPR B;  5EX0 A;  5KJK A;  3RU0 A;  3TG5 A;  3F9X A;  3MO0 A;  4NJ5 A;  3EP0 A;  3S8P A;  3KMA A;  3KMJ A;  5LSX A;  4E47 A;  2F69 A;  5TEG A;  3KMT A;  4IJ8 A;  4QEO A;  3HNA A;  3K5K A;  2R3A A;  3M58 A;  3OS5 A;  3M59 A;  4WUY A;  4H12 A;  3BO5 A;  3DB5 A;  5JIN A;  3QWP A;  1H3I A;  3PDN A;  5CCM A;  3FPD A;  3RAY A;  3SW9 A;  4AU7 A;  5KJN A;  4RZ0 A;  4YND A;  3VV0 A;  3S7D A;  4O30 A;  5JHN A;  1ML9 A;  3QWV A;  3OXF A;  3VUZ A;  5T5G A;  2G46 A;  4QEN A;  3M57 A;  1O9S A;  3M55 A;  3CBO A;  3OPE A;  4J7F A;  5KJM A;  3IHX A;  4J83 A;  1PEG A;  5EG2 A;  5ARG A;  5JJ0 A;  4J7I A;  5EX3 A;  4JDS A;  3F9W A;  5F6L A;  3RIB A;  1MVH A;  3QWW A;  5T0K A;  3OOI A;  1MVX A;  3DAL A;  3OXL A;  5ARF A;  4J8O A;  5CCL A;  3F9Z A;  5LSZ A;  3S7F A;  1ZKK A;  3CBP A;  4YNP A;  4FMU A;  2W5Y A;  4JLG A;  2RFI A;  4MI5 A;  3RQ4 A;  3SWC A;  4LDG A;  4QEP A;  4MI0 A;  3M54 A;  4O6F A;  1N3J A;  2IGQ A;  2W5Z A;  4BUP A;  4IJD A;  2O8J A;  5T0M A;  4I51 A;  3CBM A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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