5JINA

Structure of g9a set-domain with histone h3k9m mutant peptide and bound s-adenosylmethionine
Total Genus 77
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
77
sequence length
273
structure length
273
Chain Sequence
IRTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title S-adenosyl methionine is necessary for inhibition of the methyltransferase G9a by the lysine 9 to methionine mutation on histone H3.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Transferase
molecule keywords Histone-lysine N-methyltransferase EHMT2
total genus 77
structure length 273
sequence length 273
chains with identical sequence B
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2016-04-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF05033 Pre-SET Pre-SET motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 5jinA00
3CBMA 3DB5A 3OOIA 2JV0A 1ML9A 4YNMA 5HI7A 5LSZA 1O9SA 4YPUA 2O8JA 3EP0A 3KMJA 3KMTA 3M56A 4LDGA 3QWVA 5CCLA 5EX3A 5CCMA 5CPRB 4J8OA 3M58A 5F6KC 1PEGA 5JIYA 4NJ5A 3S7JA 5TTFA 3F9XA 3OXLA 5T0KA 5ARGA 4J7IA 5TH7A 3VV0A 2IGQA 4YPEA 3M54A 2R3AA 5KJNA 2F69A 2RFIA 3RIBA 5T0MA 3RAYA 3CBPA 4QENA 3BO5A 3F9ZA 1N6AA 4RZ0A 5F6LA 5EG2A 1MVXA 5KJKA 3KMAA 3S7FA 2G46A 4J83A 3MO0A 5KJMA 3M55A 3QWWA 1MUFA 4MI5A 3DALA 4NVQA 3TG4A 4YNDA 4YPAA 3MO5A 2BQZA 4Z4PA 3SWCA 3M5AA 4J7FA 3MEKA 3N71A 4O6FA 4FMUA 3TG5A 1ZKKA 5JINA 4E47A 5HQ8A 5TEGA 3MO2A 5JJ0A 3M53A 3S7DA 3OXFA 3K5KA 3QWPA 4C1QA 5LSXA 4JLGA 4BUPA 1XQHA 4YNPA 4I51A 3RU0A 1MVHA 1N3JA 5T5GA 5KJLA 1N6CA 3CBOA 2W5YA 4O30A 3OS5A 1H3IA 4JDSA 3OXGA 4H12A 4WUYA 4QEOA 3M59A 3S8PA 3RQ4A 5EX0A 4IJDA 3SW9A 1MT6A 5JHNA 3FPDA 3PDNA 4QEPA 3M57A 5AYFA 2QPWA 3IHXA 4IJ8A 3OPEA 3F9YA 3RJWA 5F5EA 5ARFA 3F9WA 4MI0A 3S7BA 5F59A 4AU7A 2W5ZA 3HNAA 3VUZA
chains in the Genus database with same CATH superfamily
3CBMA 3DB5A 3OOIA 2JV0A 1ML9A 4YNMA 5HI7A 5LSZA 1O9SA 4YPUA 2O8JA 3EP0A 3KMJA 3KMTA 3M56A 4LDGA 3QWVA 5CCLA 5EX3A 5CCMA 5CPRB 4J8OA 3M58A 5F6KC 1PEGA 5JIYA 4NJ5A 3S7JA 5TTFA 3F9XA 3OXLA 5T0KA 5ARGA 4J7IA 5TH7A 3VV0A 2IGQA 4YPEA 3M54A 2R3AA 5KJNA 2F69A 2RFIA 3RIBA 5T0MA 3RAYA 3CBPA 4QENA 3BO5A 3F9ZA 1N6AA 4RZ0A 5F6LA 5EG2A 1MVXA 5KJKA 3KMAA 3S7FA 2G46A 4J83A 3MO0A 5KJMA 3M55A 3QWWA 1MUFA 4MI5A 3DALA 4NVQA 3TG4A 4YNDA 4YPAA 3MO5A 2BQZA 4Z4PA 3SWCA 3M5AA 4J7FA 3MEKA 3N71A 4O6FA 4FMUA 3TG5A 1ZKKA 5JINA 4E47A 5HQ8A 5TEGA 3MO2A 5JJ0A 3M53A 3S7DA 3OXFA 3K5KA 3QWPA 4C1QA 5LSXA 4JLGA 4BUPA 1XQHA 4YNPA 4I51A 3RU0A 1MVHA 1N3JA 5T5GA 5KJLA 1N6CA 3CBOA 2W5YA 4O30A 3OS5A 1H3IA 4JDSA 3OXGA 4H12A 4WUYA 4QEOA 3M59A 3S8PA 3RQ4A 5EX0A 4IJDA 3SW9A 1MT6A 5JHNA 3FPDA 3PDNA 4QEPA 3M57A 5AYFA 2QPWA 3IHXA 4IJ8A 3OPEA 3F9YA 3RJWA 5F5EA 5ARFA 3F9WA 4MI0A 3S7BA 5F59A 4AU7A 2W5ZA 3HNAA 3VUZA
chains in the Genus database with same CATH topology
3CBMA 3DB5A 3OOIA 2JV0A 1ML9A 4YNMA 5HI7A 5LSZA 1O9SA 4YPUA 2O8JA 3EP0A 3KMJA 3KMTA 3M56A 4LDGA 3QWVA 5CCLA 5EX3A 5CCMA 5CPRB 4J8OA 3M58A 5F6KC 1PEGA 5JIYA 4NJ5A 3S7JA 5TTFA 3F9XA 3OXLA 5T0KA 5ARGA 4J7IA 5TH7A 3VV0A 2IGQA 4YPEA 3M54A 2R3AA 5KJNA 2F69A 2RFIA 3RIBA 5T0MA 3RAYA 3CBPA 4QENA 3BO5A 3F9ZA 1N6AA 4RZ0A 5F6LA 5EG2A 1MVXA 5KJKA 3KMAA 3S7FA 2G46A 4J83A 3MO0A 5KJMA 3M55A 3QWWA 1MUFA 4MI5A 3DALA 4NVQA 3TG4A 4YNDA 4YPAA 3MO5A 2BQZA 4Z4PA 3SWCA 3M5AA 4J7FA 3MEKA 3N71A 4O6FA 4FMUA 3TG5A 1ZKKA 5JINA 4E47A 5HQ8A 5TEGA 3MO2A 5JJ0A 3M53A 3S7DA 3OXFA 3K5KA 3QWPA 4C1QA 5LSXA 4JLGA 4BUPA 1XQHA 4YNPA 4I51A 3RU0A 1MVHA 1N3JA 5T5GA 5KJLA 1N6CA 3CBOA 2W5YA 4O30A 3OS5A 1H3IA 4JDSA 3OXGA 4H12A 4WUYA 4QEOA 3M59A 3S8PA 3RQ4A 5EX0A 4IJDA 3SW9A 1MT6A 5JHNA 3FPDA 3PDNA 4QEPA 3M57A 5AYFA 2QPWA 3IHXA 4IJ8A 3OPEA 3F9YA 3RJWA 5F5EA 5ARFA 3F9WA 4MI0A 3S7BA 5F59A 4AU7A 2W5ZA 3HNAA 3VUZA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3CBM A;  3DB5 A;  3OOI A;  2JV0 A;  1ML9 A;  4YNM A;  5HI7 A;  5LSZ A;  1O9S A;  4YPU A;  2O8J A;  3EP0 A;  3KMJ A;  3KMT A;  3M56 A;  4LDG A;  3QWV A;  5CCL A;  5EX3 A;  5CCM A;  5CPR B;  4J8O A;  3M58 A;  5F6K C;  1PEG A;  5JIY A;  4NJ5 A;  3S7J A;  5TTF A;  3F9X A;  3OXL A;  5T0K A;  5ARG A;  4J7I A;  5TH7 A;  3VV0 A;  2IGQ A;  4YPE A;  3M54 A;  2R3A A;  5KJN A;  2F69 A;  2RFI A;  3RIB A;  5T0M A;  3RAY A;  3CBP A;  4QEN A;  3BO5 A;  3F9Z A;  1N6A A;  4RZ0 A;  5F6L A;  5EG2 A;  1MVX A;  5KJK A;  3KMA A;  3S7F A;  2G46 A;  4J83 A;  3MO0 A;  5KJM A;  3M55 A;  3QWW A;  1MUF A;  4MI5 A;  3DAL A;  4NVQ A;  3TG4 A;  4YND A;  4YPA A;  3MO5 A;  2BQZ A;  4Z4P A;  3SWC A;  3M5A A;  4J7F A;  3MEK A;  3N71 A;  4O6F A;  4FMU A;  3TG5 A;  1ZKK A;  5JIN A;  4E47 A;  5HQ8 A;  5TEG A;  3MO2 A;  5JJ0 A;  3M53 A;  3S7D A;  3OXF A;  3K5K A;  3QWP A;  4C1Q A;  5LSX A;  4JLG A;  4BUP A;  1XQH A;  4YNP A;  4I51 A;  3RU0 A;  1MVH A;  1N3J A;  5T5G A;  5KJL A;  1N6C A;  3CBO A;  2W5Y A;  4O30 A;  3OS5 A;  1H3I A;  4JDS A;  3OXG A;  4H12 A;  4WUY A;  4QEO A;  3M59 A;  3S8P A;  3RQ4 A;  5EX0 A;  4IJD A;  3SW9 A;  1MT6 A;  5JHN A;  3FPD A;  3PDN A;  4QEP A;  3M57 A;  5AYF A;  2QPW A;  3IHX A;  4IJ8 A;  3OPE A;  3F9Y A;  3RJW A;  5F5E A;  5ARF A;  3F9W A;  4MI0 A;  3S7B A;  5F59 A;  4AU7 A;  2W5Z A;  3HNA A;  3VUZ A; 
#chains in the Genus database with same CATH topology
 3CBM A;  3DB5 A;  3OOI A;  2JV0 A;  1ML9 A;  4YNM A;  5HI7 A;  5LSZ A;  1O9S A;  4YPU A;  2O8J A;  3EP0 A;  3KMJ A;  3KMT A;  3M56 A;  4LDG A;  3QWV A;  5CCL A;  5EX3 A;  5CCM A;  5CPR B;  4J8O A;  3M58 A;  5F6K C;  1PEG A;  5JIY A;  4NJ5 A;  3S7J A;  5TTF A;  3F9X A;  3OXL A;  5T0K A;  5ARG A;  4J7I A;  5TH7 A;  3VV0 A;  2IGQ A;  4YPE A;  3M54 A;  2R3A A;  5KJN A;  2F69 A;  2RFI A;  3RIB A;  5T0M A;  3RAY A;  3CBP A;  4QEN A;  3BO5 A;  3F9Z A;  1N6A A;  4RZ0 A;  5F6L A;  5EG2 A;  1MVX A;  5KJK A;  3KMA A;  3S7F A;  2G46 A;  4J83 A;  3MO0 A;  5KJM A;  3M55 A;  3QWW A;  1MUF A;  4MI5 A;  3DAL A;  4NVQ A;  3TG4 A;  4YND A;  4YPA A;  3MO5 A;  2BQZ A;  4Z4P A;  3SWC A;  3M5A A;  4J7F A;  3MEK A;  3N71 A;  4O6F A;  4FMU A;  3TG5 A;  1ZKK A;  5JIN A;  4E47 A;  5HQ8 A;  5TEG A;  3MO2 A;  5JJ0 A;  3M53 A;  3S7D A;  3OXF A;  3K5K A;  3QWP A;  4C1Q A;  5LSX A;  4JLG A;  4BUP A;  1XQH A;  4YNP A;  4I51 A;  3RU0 A;  1MVH A;  1N3J A;  5T5G A;  5KJL A;  1N6C A;  3CBO A;  2W5Y A;  4O30 A;  3OS5 A;  1H3I A;  4JDS A;  3OXG A;  4H12 A;  4WUY A;  4QEO A;  3M59 A;  3S8P A;  3RQ4 A;  5EX0 A;  4IJD A;  3SW9 A;  1MT6 A;  5JHN A;  3FPD A;  3PDN A;  4QEP A;  3M57 A;  5AYF A;  2QPW A;  3IHX A;  4IJ8 A;  3OPE A;  3F9Y A;  3RJW A;  5F5E A;  5ARF A;  3F9W A;  4MI0 A;  3S7B A;  5F59 A;  4AU7 A;  2W5Z A;  3HNA A;  3VUZ A; 
#chains in the Genus database with same CATH homology
 3CBM A;  3DB5 A;  3OOI A;  2JV0 A;  1ML9 A;  4YNM A;  5HI7 A;  5LSZ A;  1O9S A;  4YPU A;  2O8J A;  3EP0 A;  3KMJ A;  3KMT A;  3M56 A;  4LDG A;  3QWV A;  5CCL A;  5EX3 A;  5CCM A;  5CPR B;  4J8O A;  3M58 A;  5F6K C;  1PEG A;  5JIY A;  4NJ5 A;  3S7J A;  5TTF A;  3F9X A;  3OXL A;  5T0K A;  5ARG A;  4J7I A;  5TH7 A;  3VV0 A;  2IGQ A;  4YPE A;  3M54 A;  2R3A A;  5KJN A;  2F69 A;  2RFI A;  3RIB A;  5T0M A;  3RAY A;  3CBP A;  4QEN A;  3BO5 A;  3F9Z A;  1N6A A;  4RZ0 A;  5F6L A;  5EG2 A;  1MVX A;  5KJK A;  3KMA A;  3S7F A;  2G46 A;  4J83 A;  3MO0 A;  5KJM A;  3M55 A;  3QWW A;  1MUF A;  4MI5 A;  3DAL A;  4NVQ A;  3TG4 A;  4YND A;  4YPA A;  3MO5 A;  2BQZ A;  4Z4P A;  3SWC A;  3M5A A;  4J7F A;  3MEK A;  3N71 A;  4O6F A;  4FMU A;  3TG5 A;  1ZKK A;  5JIN A;  4E47 A;  5HQ8 A;  5TEG A;  3MO2 A;  5JJ0 A;  3M53 A;  3S7D A;  3OXF A;  3K5K A;  3QWP A;  4C1Q A;  5LSX A;  4JLG A;  4BUP A;  1XQH A;  4YNP A;  4I51 A;  3RU0 A;  1MVH A;  1N3J A;  5T5G A;  5KJL A;  1N6C A;  3CBO A;  2W5Y A;  4O30 A;  3OS5 A;  1H3I A;  4JDS A;  3OXG A;  4H12 A;  4WUY A;  4QEO A;  3M59 A;  3S8P A;  3RQ4 A;  5EX0 A;  4IJD A;  3SW9 A;  1MT6 A;  5JHN A;  3FPD A;  3PDN A;  4QEP A;  3M57 A;  5AYF A;  2QPW A;  3IHX A;  4IJ8 A;  3OPE A;  3F9Y A;  3RJW A;  5F5E A;  5ARF A;  3F9W A;  4MI0 A;  3S7B A;  5F59 A;  4AU7 A;  2W5Z A;  3HNA A;  3VUZ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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