5JINA

Structure of g9a set-domain with histone h3k9m mutant peptide and bound s-adenosylmethionine
Total Genus 77
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
77
sequence length
273
structure length
273
Chain Sequence
IRTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSR
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title S-adenosyl methionine is necessary for inhibition of the methyltransferase G9a by the lysine 9 to methionine mutation on histone H3.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Transferase
molecule keywords Histone-lysine N-methyltransferase EHMT2
total genus 77
structure length 273
sequence length 273
chains with identical sequence B
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2016-04-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF05033 Pre-SET Pre-SET motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 5jinA00
1MUFA 4NJ5A 3RQ4A 4J7FA 4J8OA 3OPEA 4BUPA 1H3IA 4JLGA 4QEOA 1N6CA 1ML9A 2W5YA 3M58A 4Z4PA 3TG5A 3KMAA 2QPWA 4MI5A 4YNMA 2W5ZA 5JIYA 3IHXA 3MO5A 4MI0A 5KJKA 4H12A 4I51A 5KJMA 5ARGA 4QEPA 3S7FA 3F9WA 3SW9A 3OS5A 3M57A 3MO2A 3VUZA 3M56A 4WUYA 3K5KA 4O30A 4YNDA 3MO0A 4J7IA 5F6LA 5EX3A 3QWVA 3PDNA 3HNAA 4C1QA 5AYFA 5EX0A 3EP0A 3M59A 3RIBA 5ARFA 5T5GA 3F9YA 3QWWA 3N71A 5T0MA 5TH7A 4IJ8A 3S7JA 5JINA 3OXGA 3SWCA 3F9ZA 3F9XA 3M5AA 5KJNA 3KMTA 1MVHA 4YPAA 3KMJA 2R3AA 5EG2A 3M53A 5F59A 3CBOA 3RAYA 2BQZA 3DB5A 4E47A 5CCMA 1ZKKA 3OXLA 2G46A 2IGQA 4O6FA 2JV0A 3M54A 5TTFA 5JJ0A 3FPDA 3OXFA 3S7DA 4QENA 4JDSA 1MT6A 3TG4A 4YPUA 4RZ0A 5HQ8A 4YPEA 1PEGA 5CPRB 5F5EA 4AU7A 1MVXA 4YNPA 5LSZA 5TEGA 1N6AA 5T0KA 2RFIA 2O8JA 5LSXA 3S7BA 3OOIA 4J83A 2F69A 3S8PA 5HI7A 1XQHA 3CBMA 4IJDA 1N3JA 5JHNA 4FMUA 3DALA 3MEKA 1O9SA 3RJWA 3RU0A 3VV0A 3CBPA 5F6KC 5KJLA 3BO5A 3QWPA 5CCLA 4LDGA 4NVQA 3M55A
chains in the Genus database with same CATH superfamily
1MUFA 4NJ5A 3RQ4A 4J7FA 4J8OA 3OPEA 4BUPA 1H3IA 4JLGA 4QEOA 1N6CA 1ML9A 2W5YA 3M58A 4Z4PA 3TG5A 3KMAA 2QPWA 4MI5A 4YNMA 2W5ZA 5JIYA 3IHXA 3MO5A 4MI0A 5KJKA 4H12A 4I51A 5KJMA 5ARGA 4QEPA 3S7FA 3F9WA 3SW9A 3OS5A 3M57A 3MO2A 3VUZA 3M56A 4WUYA 3K5KA 4O30A 4YNDA 3MO0A 4J7IA 5F6LA 5EX3A 3QWVA 3PDNA 3HNAA 4C1QA 5AYFA 5EX0A 3EP0A 3M59A 3RIBA 5ARFA 5T5GA 3F9YA 3QWWA 3N71A 5T0MA 5TH7A 4IJ8A 3S7JA 5JINA 3OXGA 3SWCA 3F9ZA 3F9XA 3M5AA 5KJNA 3KMTA 1MVHA 4YPAA 3KMJA 2R3AA 5EG2A 3M53A 5F59A 3CBOA 3RAYA 2BQZA 3DB5A 4E47A 5CCMA 1ZKKA 3OXLA 2G46A 2IGQA 4O6FA 2JV0A 3M54A 5TTFA 5JJ0A 3FPDA 3OXFA 3S7DA 4QENA 4JDSA 1MT6A 3TG4A 4YPUA 4RZ0A 5HQ8A 4YPEA 1PEGA 5CPRB 5F5EA 4AU7A 1MVXA 4YNPA 5LSZA 5TEGA 1N6AA 5T0KA 2RFIA 2O8JA 5LSXA 3S7BA 3OOIA 4J83A 2F69A 3S8PA 5HI7A 1XQHA 3CBMA 4IJDA 1N3JA 5JHNA 4FMUA 3DALA 3MEKA 1O9SA 3RJWA 3RU0A 3VV0A 3CBPA 5F6KC 5KJLA 3BO5A 3QWPA 5CCLA 4LDGA 4NVQA 3M55A
chains in the Genus database with same CATH topology
1MUFA 4NJ5A 3RQ4A 4J7FA 4J8OA 3OPEA 4BUPA 1H3IA 4JLGA 4QEOA 1N6CA 1ML9A 2W5YA 3M58A 4Z4PA 3TG5A 3KMAA 2QPWA 4MI5A 4YNMA 2W5ZA 5JIYA 3IHXA 3MO5A 4MI0A 5KJKA 4H12A 4I51A 5KJMA 5ARGA 4QEPA 3S7FA 3F9WA 3SW9A 3OS5A 3M57A 3MO2A 3VUZA 3M56A 4WUYA 3K5KA 4O30A 4YNDA 3MO0A 4J7IA 5F6LA 5EX3A 3QWVA 3PDNA 3HNAA 4C1QA 5AYFA 5EX0A 3EP0A 3M59A 3RIBA 5ARFA 5T5GA 3F9YA 3QWWA 3N71A 5T0MA 5TH7A 4IJ8A 3S7JA 5JINA 3OXGA 3SWCA 3F9ZA 3F9XA 3M5AA 5KJNA 3KMTA 1MVHA 4YPAA 3KMJA 2R3AA 5EG2A 3M53A 5F59A 3CBOA 3RAYA 2BQZA 3DB5A 4E47A 5CCMA 1ZKKA 3OXLA 2G46A 2IGQA 4O6FA 2JV0A 3M54A 5TTFA 5JJ0A 3FPDA 3OXFA 3S7DA 4QENA 4JDSA 1MT6A 3TG4A 4YPUA 4RZ0A 5HQ8A 4YPEA 1PEGA 5CPRB 5F5EA 4AU7A 1MVXA 4YNPA 5LSZA 5TEGA 1N6AA 5T0KA 2RFIA 2O8JA 5LSXA 3S7BA 3OOIA 4J83A 2F69A 3S8PA 5HI7A 1XQHA 3CBMA 4IJDA 1N3JA 5JHNA 4FMUA 3DALA 3MEKA 1O9SA 3RJWA 3RU0A 3VV0A 3CBPA 5F6KC 5KJLA 3BO5A 3QWPA 5CCLA 4LDGA 4NVQA 3M55A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1MUF A;  4NJ5 A;  3RQ4 A;  4J7F A;  4J8O A;  3OPE A;  4BUP A;  1H3I A;  4JLG A;  4QEO A;  1N6C A;  1ML9 A;  2W5Y A;  3M58 A;  4Z4P A;  3TG5 A;  3KMA A;  2QPW A;  4MI5 A;  4YNM A;  2W5Z A;  5JIY A;  3IHX A;  3MO5 A;  4MI0 A;  5KJK A;  4H12 A;  4I51 A;  5KJM A;  5ARG A;  4QEP A;  3S7F A;  3F9W A;  3SW9 A;  3OS5 A;  3M57 A;  3MO2 A;  3VUZ A;  3M56 A;  4WUY A;  3K5K A;  4O30 A;  4YND A;  3MO0 A;  4J7I A;  5F6L A;  5EX3 A;  3QWV A;  3PDN A;  3HNA A;  4C1Q A;  5AYF A;  5EX0 A;  3EP0 A;  3M59 A;  3RIB A;  5ARF A;  5T5G A;  3F9Y A;  3QWW A;  3N71 A;  5T0M A;  5TH7 A;  4IJ8 A;  3S7J A;  5JIN A;  3OXG A;  3SWC A;  3F9Z A;  3F9X A;  3M5A A;  5KJN A;  3KMT A;  1MVH A;  4YPA A;  3KMJ A;  2R3A A;  5EG2 A;  3M53 A;  5F59 A;  3CBO A;  3RAY A;  2BQZ A;  3DB5 A;  4E47 A;  5CCM A;  1ZKK A;  3OXL A;  2G46 A;  2IGQ A;  4O6F A;  2JV0 A;  3M54 A;  5TTF A;  5JJ0 A;  3FPD A;  3OXF A;  3S7D A;  4QEN A;  4JDS A;  1MT6 A;  3TG4 A;  4YPU A;  4RZ0 A;  5HQ8 A;  4YPE A;  1PEG A;  5CPR B;  5F5E A;  4AU7 A;  1MVX A;  4YNP A;  5LSZ A;  5TEG A;  1N6A A;  5T0K A;  2RFI A;  2O8J A;  5LSX A;  3S7B A;  3OOI A;  4J83 A;  2F69 A;  3S8P A;  5HI7 A;  1XQH A;  3CBM A;  4IJD A;  1N3J A;  5JHN A;  4FMU A;  3DAL A;  3MEK A;  1O9S A;  3RJW A;  3RU0 A;  3VV0 A;  3CBP A;  5F6K C;  5KJL A;  3BO5 A;  3QWP A;  5CCL A;  4LDG A;  4NVQ A;  3M55 A; 
#chains in the Genus database with same CATH topology
 1MUF A;  4NJ5 A;  3RQ4 A;  4J7F A;  4J8O A;  3OPE A;  4BUP A;  1H3I A;  4JLG A;  4QEO A;  1N6C A;  1ML9 A;  2W5Y A;  3M58 A;  4Z4P A;  3TG5 A;  3KMA A;  2QPW A;  4MI5 A;  4YNM A;  2W5Z A;  5JIY A;  3IHX A;  3MO5 A;  4MI0 A;  5KJK A;  4H12 A;  4I51 A;  5KJM A;  5ARG A;  4QEP A;  3S7F A;  3F9W A;  3SW9 A;  3OS5 A;  3M57 A;  3MO2 A;  3VUZ A;  3M56 A;  4WUY A;  3K5K A;  4O30 A;  4YND A;  3MO0 A;  4J7I A;  5F6L A;  5EX3 A;  3QWV A;  3PDN A;  3HNA A;  4C1Q A;  5AYF A;  5EX0 A;  3EP0 A;  3M59 A;  3RIB A;  5ARF A;  5T5G A;  3F9Y A;  3QWW A;  3N71 A;  5T0M A;  5TH7 A;  4IJ8 A;  3S7J A;  5JIN A;  3OXG A;  3SWC A;  3F9Z A;  3F9X A;  3M5A A;  5KJN A;  3KMT A;  1MVH A;  4YPA A;  3KMJ A;  2R3A A;  5EG2 A;  3M53 A;  5F59 A;  3CBO A;  3RAY A;  2BQZ A;  3DB5 A;  4E47 A;  5CCM A;  1ZKK A;  3OXL A;  2G46 A;  2IGQ A;  4O6F A;  2JV0 A;  3M54 A;  5TTF A;  5JJ0 A;  3FPD A;  3OXF A;  3S7D A;  4QEN A;  4JDS A;  1MT6 A;  3TG4 A;  4YPU A;  4RZ0 A;  5HQ8 A;  4YPE A;  1PEG A;  5CPR B;  5F5E A;  4AU7 A;  1MVX A;  4YNP A;  5LSZ A;  5TEG A;  1N6A A;  5T0K A;  2RFI A;  2O8J A;  5LSX A;  3S7B A;  3OOI A;  4J83 A;  2F69 A;  3S8P A;  5HI7 A;  1XQH A;  3CBM A;  4IJD A;  1N3J A;  5JHN A;  4FMU A;  3DAL A;  3MEK A;  1O9S A;  3RJW A;  3RU0 A;  3VV0 A;  3CBP A;  5F6K C;  5KJL A;  3BO5 A;  3QWP A;  5CCL A;  4LDG A;  4NVQ A;  3M55 A; 
#chains in the Genus database with same CATH homology
 1MUF A;  4NJ5 A;  3RQ4 A;  4J7F A;  4J8O A;  3OPE A;  4BUP A;  1H3I A;  4JLG A;  4QEO A;  1N6C A;  1ML9 A;  2W5Y A;  3M58 A;  4Z4P A;  3TG5 A;  3KMA A;  2QPW A;  4MI5 A;  4YNM A;  2W5Z A;  5JIY A;  3IHX A;  3MO5 A;  4MI0 A;  5KJK A;  4H12 A;  4I51 A;  5KJM A;  5ARG A;  4QEP A;  3S7F A;  3F9W A;  3SW9 A;  3OS5 A;  3M57 A;  3MO2 A;  3VUZ A;  3M56 A;  4WUY A;  3K5K A;  4O30 A;  4YND A;  3MO0 A;  4J7I A;  5F6L A;  5EX3 A;  3QWV A;  3PDN A;  3HNA A;  4C1Q A;  5AYF A;  5EX0 A;  3EP0 A;  3M59 A;  3RIB A;  5ARF A;  5T5G A;  3F9Y A;  3QWW A;  3N71 A;  5T0M A;  5TH7 A;  4IJ8 A;  3S7J A;  5JIN A;  3OXG A;  3SWC A;  3F9Z A;  3F9X A;  3M5A A;  5KJN A;  3KMT A;  1MVH A;  4YPA A;  3KMJ A;  2R3A A;  5EG2 A;  3M53 A;  5F59 A;  3CBO A;  3RAY A;  2BQZ A;  3DB5 A;  4E47 A;  5CCM A;  1ZKK A;  3OXL A;  2G46 A;  2IGQ A;  4O6F A;  2JV0 A;  3M54 A;  5TTF A;  5JJ0 A;  3FPD A;  3OXF A;  3S7D A;  4QEN A;  4JDS A;  1MT6 A;  3TG4 A;  4YPU A;  4RZ0 A;  5HQ8 A;  4YPE A;  1PEG A;  5CPR B;  5F5E A;  4AU7 A;  1MVX A;  4YNP A;  5LSZ A;  5TEG A;  1N6A A;  5T0K A;  2RFI A;  2O8J A;  5LSX A;  3S7B A;  3OOI A;  4J83 A;  2F69 A;  3S8P A;  5HI7 A;  1XQH A;  3CBM A;  4IJD A;  1N3J A;  5JHN A;  4FMU A;  3DAL A;  3MEK A;  1O9S A;  3RJW A;  3RU0 A;  3VV0 A;  3CBP A;  5F6K C;  5KJL A;  3BO5 A;  3QWP A;  5CCL A;  4LDG A;  4NVQ A;  3M55 A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...