5JINA

Structure of g9a set-domain with histone h3k9m mutant peptide and bound s-adenosylmethionine
Total Genus 77
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
77
sequence length
273
structure length
273
Chain Sequence
IRTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Histone-lysine N-methyltransferase EHMT2
publication title S-adenosyl methionine is necessary for inhibition of the methyltransferase G9a by the lysine 9 to methionine mutation on histone H3.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Transferase
total genus 77
structure length 273
sequence length 273
chains with identical sequence B
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2016-04-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF05033 Pre-SET Pre-SET motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 5jinA00
2R3AA 3FPDA 1N6AA 4I51A 3MO2A 3SW9A 2IGQA 4YPAA 5HQ8A 1N3JA 4YPUA 3OS5A 3BO5A 3F9ZA 5TH7A 1H3IA 1PEGA 4QEPA 3M59A 2W5ZA 3S7BA 5LSZA 2RFIA 3M56A 5CCMA 4O6FA 3MEKA 3M54A 3HNAA 3RIBA 5F5EA 4MI5A 3KMTA 2QPWA 3S7JA 4O30A 5CCLA 4NVQA 4MI0A 4LDGA 5TTFA 4C1QA 3OXGA 1MT6A 2W5YA 4JDSA 5KJLA 4J7IA 5ARGA 3S7DA 3M53A 1MVHA 4YNDA 4RZ0A 3QWWA 4YNPA 5T0MA 3F9WA 3PDNA 5TEGA 3KMJA 3OOIA 5KJKA 4IJ8A 2F69A 3CBOA 4WUYA 5AYFA 1MVXA 5JJ0A 3MO0A 3N71A 3IHXA 3VUZA 4J8OA 5JIYA 4FMUA 4H12A 3K5KA 1ZKKA 4JLGA 3CBPA 3RAYA 3RU0A 3TG4A 4E47A 5HI7A 3CBMA 3M57A 5EG2A 1O9SA 5F59A 4J7FA 5F6KC 5JINA 4BUPA 5ARFA 3S8PA 4YPEA 3M5AA 3RJWA 3M58A 5CPRB 2JV0A 3S7FA 1ML9A 5F6LA 3F9YA 4QENA 2BQZA 5KJMA 3OPEA 3VV0A 4J83A 3QWVA 3QWPA 5T5GA 3EP0A 3OXFA 5LSXA 2O8JA 5T0KA 1XQHA 3OXLA 4Z4PA 4AU7A 3TG5A 3SWCA 4YNMA 3M55A 4QEOA 5EX0A 4NJ5A 3F9XA 3DB5A 5JHNA 2G46A 5EX3A 3RQ4A 1MUFA 3DALA 4IJDA 3KMAA 5KJNA 3MO5A 1N6CA
chains in the Genus database with same CATH superfamily
2R3AA 3FPDA 1N6AA 4I51A 3MO2A 3SW9A 2IGQA 4YPAA 5HQ8A 1N3JA 4YPUA 3OS5A 3BO5A 3F9ZA 5TH7A 1H3IA 1PEGA 4QEPA 3M59A 2W5ZA 3S7BA 5LSZA 2RFIA 3M56A 5CCMA 4O6FA 3MEKA 3M54A 3HNAA 3RIBA 5F5EA 4MI5A 3KMTA 2QPWA 3S7JA 4O30A 5CCLA 4NVQA 4MI0A 4LDGA 5TTFA 4C1QA 3OXGA 1MT6A 2W5YA 4JDSA 5KJLA 4J7IA 5ARGA 3S7DA 3M53A 1MVHA 4YNDA 4RZ0A 3QWWA 4YNPA 5T0MA 3F9WA 3PDNA 5TEGA 3KMJA 3OOIA 5KJKA 4IJ8A 2F69A 3CBOA 4WUYA 5AYFA 1MVXA 5JJ0A 3MO0A 3N71A 3IHXA 3VUZA 4J8OA 5JIYA 4FMUA 4H12A 3K5KA 1ZKKA 4JLGA 3CBPA 3RAYA 3RU0A 3TG4A 4E47A 5HI7A 3CBMA 3M57A 5EG2A 1O9SA 5F59A 4J7FA 5F6KC 5JINA 4BUPA 5ARFA 3S8PA 4YPEA 3M5AA 3RJWA 3M58A 5CPRB 2JV0A 3S7FA 1ML9A 5F6LA 3F9YA 4QENA 2BQZA 5KJMA 3OPEA 3VV0A 4J83A 3QWVA 3QWPA 5T5GA 3EP0A 3OXFA 5LSXA 2O8JA 5T0KA 1XQHA 3OXLA 4Z4PA 4AU7A 3TG5A 3SWCA 4YNMA 3M55A 4QEOA 5EX0A 4NJ5A 3F9XA 3DB5A 5JHNA 2G46A 5EX3A 3RQ4A 1MUFA 3DALA 4IJDA 3KMAA 5KJNA 3MO5A 1N6CA
chains in the Genus database with same CATH topology
2R3AA 3FPDA 1N6AA 4I51A 3MO2A 3SW9A 2IGQA 4YPAA 5HQ8A 1N3JA 4YPUA 3OS5A 3BO5A 3F9ZA 5TH7A 1H3IA 1PEGA 4QEPA 3M59A 2W5ZA 3S7BA 5LSZA 2RFIA 3M56A 5CCMA 4O6FA 3MEKA 3M54A 3HNAA 3RIBA 5F5EA 4MI5A 3KMTA 2QPWA 3S7JA 4O30A 5CCLA 4NVQA 4MI0A 4LDGA 5TTFA 4C1QA 3OXGA 1MT6A 2W5YA 4JDSA 5KJLA 4J7IA 5ARGA 3S7DA 3M53A 1MVHA 4YNDA 4RZ0A 3QWWA 4YNPA 5T0MA 3F9WA 3PDNA 5TEGA 3KMJA 3OOIA 5KJKA 4IJ8A 2F69A 3CBOA 4WUYA 5AYFA 1MVXA 5JJ0A 3MO0A 3N71A 3IHXA 3VUZA 4J8OA 5JIYA 4FMUA 4H12A 3K5KA 1ZKKA 4JLGA 3CBPA 3RAYA 3RU0A 3TG4A 4E47A 5HI7A 3CBMA 3M57A 5EG2A 1O9SA 5F59A 4J7FA 5F6KC 5JINA 4BUPA 5ARFA 3S8PA 4YPEA 3M5AA 3RJWA 3M58A 5CPRB 2JV0A 3S7FA 1ML9A 5F6LA 3F9YA 4QENA 2BQZA 5KJMA 3OPEA 3VV0A 4J83A 3QWVA 3QWPA 5T5GA 3EP0A 3OXFA 5LSXA 2O8JA 5T0KA 1XQHA 3OXLA 4Z4PA 4AU7A 3TG5A 3SWCA 4YNMA 3M55A 4QEOA 5EX0A 4NJ5A 3F9XA 3DB5A 5JHNA 2G46A 5EX3A 3RQ4A 1MUFA 3DALA 4IJDA 3KMAA 5KJNA 3MO5A 1N6CA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2R3A A;  3FPD A;  1N6A A;  4I51 A;  3MO2 A;  3SW9 A;  2IGQ A;  4YPA A;  5HQ8 A;  1N3J A;  4YPU A;  3OS5 A;  3BO5 A;  3F9Z A;  5TH7 A;  1H3I A;  1PEG A;  4QEP A;  3M59 A;  2W5Z A;  3S7B A;  5LSZ A;  2RFI A;  3M56 A;  5CCM A;  4O6F A;  3MEK A;  3M54 A;  3HNA A;  3RIB A;  5F5E A;  4MI5 A;  3KMT A;  2QPW A;  3S7J A;  4O30 A;  5CCL A;  4NVQ A;  4MI0 A;  4LDG A;  5TTF A;  4C1Q A;  3OXG A;  1MT6 A;  2W5Y A;  4JDS A;  5KJL A;  4J7I A;  5ARG A;  3S7D A;  3M53 A;  1MVH A;  4YND A;  4RZ0 A;  3QWW A;  4YNP A;  5T0M A;  3F9W A;  3PDN A;  5TEG A;  3KMJ A;  3OOI A;  5KJK A;  4IJ8 A;  2F69 A;  3CBO A;  4WUY A;  5AYF A;  1MVX A;  5JJ0 A;  3MO0 A;  3N71 A;  3IHX A;  3VUZ A;  4J8O A;  5JIY A;  4FMU A;  4H12 A;  3K5K A;  1ZKK A;  4JLG A;  3CBP A;  3RAY A;  3RU0 A;  3TG4 A;  4E47 A;  5HI7 A;  3CBM A;  3M57 A;  5EG2 A;  1O9S A;  5F59 A;  4J7F A;  5F6K C;  5JIN A;  4BUP A;  5ARF A;  3S8P A;  4YPE A;  3M5A A;  3RJW A;  3M58 A;  5CPR B;  2JV0 A;  3S7F A;  1ML9 A;  5F6L A;  3F9Y A;  4QEN A;  2BQZ A;  5KJM A;  3OPE A;  3VV0 A;  4J83 A;  3QWV A;  3QWP A;  5T5G A;  3EP0 A;  3OXF A;  5LSX A;  2O8J A;  5T0K A;  1XQH A;  3OXL A;  4Z4P A;  4AU7 A;  3TG5 A;  3SWC A;  4YNM A;  3M55 A;  4QEO A;  5EX0 A;  4NJ5 A;  3F9X A;  3DB5 A;  5JHN A;  2G46 A;  5EX3 A;  3RQ4 A;  1MUF A;  3DAL A;  4IJD A;  3KMA A;  5KJN A;  3MO5 A;  1N6C A; 
#chains in the Genus database with same CATH topology
 2R3A A;  3FPD A;  1N6A A;  4I51 A;  3MO2 A;  3SW9 A;  2IGQ A;  4YPA A;  5HQ8 A;  1N3J A;  4YPU A;  3OS5 A;  3BO5 A;  3F9Z A;  5TH7 A;  1H3I A;  1PEG A;  4QEP A;  3M59 A;  2W5Z A;  3S7B A;  5LSZ A;  2RFI A;  3M56 A;  5CCM A;  4O6F A;  3MEK A;  3M54 A;  3HNA A;  3RIB A;  5F5E A;  4MI5 A;  3KMT A;  2QPW A;  3S7J A;  4O30 A;  5CCL A;  4NVQ A;  4MI0 A;  4LDG A;  5TTF A;  4C1Q A;  3OXG A;  1MT6 A;  2W5Y A;  4JDS A;  5KJL A;  4J7I A;  5ARG A;  3S7D A;  3M53 A;  1MVH A;  4YND A;  4RZ0 A;  3QWW A;  4YNP A;  5T0M A;  3F9W A;  3PDN A;  5TEG A;  3KMJ A;  3OOI A;  5KJK A;  4IJ8 A;  2F69 A;  3CBO A;  4WUY A;  5AYF A;  1MVX A;  5JJ0 A;  3MO0 A;  3N71 A;  3IHX A;  3VUZ A;  4J8O A;  5JIY A;  4FMU A;  4H12 A;  3K5K A;  1ZKK A;  4JLG A;  3CBP A;  3RAY A;  3RU0 A;  3TG4 A;  4E47 A;  5HI7 A;  3CBM A;  3M57 A;  5EG2 A;  1O9S A;  5F59 A;  4J7F A;  5F6K C;  5JIN A;  4BUP A;  5ARF A;  3S8P A;  4YPE A;  3M5A A;  3RJW A;  3M58 A;  5CPR B;  2JV0 A;  3S7F A;  1ML9 A;  5F6L A;  3F9Y A;  4QEN A;  2BQZ A;  5KJM A;  3OPE A;  3VV0 A;  4J83 A;  3QWV A;  3QWP A;  5T5G A;  3EP0 A;  3OXF A;  5LSX A;  2O8J A;  5T0K A;  1XQH A;  3OXL A;  4Z4P A;  4AU7 A;  3TG5 A;  3SWC A;  4YNM A;  3M55 A;  4QEO A;  5EX0 A;  4NJ5 A;  3F9X A;  3DB5 A;  5JHN A;  2G46 A;  5EX3 A;  3RQ4 A;  1MUF A;  3DAL A;  4IJD A;  3KMA A;  5KJN A;  3MO5 A;  1N6C A; 
#chains in the Genus database with same CATH homology
 2R3A A;  3FPD A;  1N6A A;  4I51 A;  3MO2 A;  3SW9 A;  2IGQ A;  4YPA A;  5HQ8 A;  1N3J A;  4YPU A;  3OS5 A;  3BO5 A;  3F9Z A;  5TH7 A;  1H3I A;  1PEG A;  4QEP A;  3M59 A;  2W5Z A;  3S7B A;  5LSZ A;  2RFI A;  3M56 A;  5CCM A;  4O6F A;  3MEK A;  3M54 A;  3HNA A;  3RIB A;  5F5E A;  4MI5 A;  3KMT A;  2QPW A;  3S7J A;  4O30 A;  5CCL A;  4NVQ A;  4MI0 A;  4LDG A;  5TTF A;  4C1Q A;  3OXG A;  1MT6 A;  2W5Y A;  4JDS A;  5KJL A;  4J7I A;  5ARG A;  3S7D A;  3M53 A;  1MVH A;  4YND A;  4RZ0 A;  3QWW A;  4YNP A;  5T0M A;  3F9W A;  3PDN A;  5TEG A;  3KMJ A;  3OOI A;  5KJK A;  4IJ8 A;  2F69 A;  3CBO A;  4WUY A;  5AYF A;  1MVX A;  5JJ0 A;  3MO0 A;  3N71 A;  3IHX A;  3VUZ A;  4J8O A;  5JIY A;  4FMU A;  4H12 A;  3K5K A;  1ZKK A;  4JLG A;  3CBP A;  3RAY A;  3RU0 A;  3TG4 A;  4E47 A;  5HI7 A;  3CBM A;  3M57 A;  5EG2 A;  1O9S A;  5F59 A;  4J7F A;  5F6K C;  5JIN A;  4BUP A;  5ARF A;  3S8P A;  4YPE A;  3M5A A;  3RJW A;  3M58 A;  5CPR B;  2JV0 A;  3S7F A;  1ML9 A;  5F6L A;  3F9Y A;  4QEN A;  2BQZ A;  5KJM A;  3OPE A;  3VV0 A;  4J83 A;  3QWV A;  3QWP A;  5T5G A;  3EP0 A;  3OXF A;  5LSX A;  2O8J A;  5T0K A;  1XQH A;  3OXL A;  4Z4P A;  4AU7 A;  3TG5 A;  3SWC A;  4YNM A;  3M55 A;  4QEO A;  5EX0 A;  4NJ5 A;  3F9X A;  3DB5 A;  5JHN A;  2G46 A;  5EX3 A;  3RQ4 A;  1MUF A;  3DAL A;  4IJD A;  3KMA A;  5KJN A;  3MO5 A;  1N6C A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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