5JINA

Structure of g9a set-domain with histone h3k9m mutant peptide and bound s-adenosylmethionine
Total Genus 77
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
77
sequence length
273
structure length
273
Chain Sequence
IRTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Histone-lysine N-methyltransferase EHMT2
publication title S-adenosyl methionine is necessary for inhibition of the methyltransferase G9a by the lysine 9 to methionine mutation on histone H3.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Transferase
total genus 77
structure length 273
sequence length 273
chains with identical sequence B
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2016-04-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF05033 Pre-SET Pre-SET motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 5jinA00
4J7FA 4YPEA 1N6AA 3FPDA 3MO2A 4J83A 4JLGA 5T5GA 4MI5A 2F69A 2O8JA 3BO5A 5AYFA 4NVQA 3S7JA 4BUPA 3CBMA 3RU0A 3M56A 2W5YA 3OOIA 3VV0A 4YNMA 5HI7A 4MI0A 2RFIA 5JINA 3F9XA 3OXLA 1N3JA 3F9WA 3M55A 3DB5A 3KMTA 1H3IA 1MUFA 3EP0A 3S8PA 5KJKA 4E47A 4LDGA 4YNDA 3RJWA 1ML9A 3OXGA 1N6CA 5T0KA 3HNAA 3M59A 2BQZA 1MT6A 3KMAA 4YPAA 3SWCA 3OXFA 3M53A 3OPEA 3S7BA 5ARGA 3KMJA 3QWVA 5F59A 3S7DA 4NJ5A 3RIBA 3VUZA 5EX3A 5JJ0A 5JIYA 3M57A 3RQ4A 4IJDA 3TG4A 5F6KC 2QPWA 3DALA 4AU7A 5TH7A 4J7IA 5JHNA 5TEGA 4H12A 4RZ0A 3MO5A 5TTFA 4WUYA 2G46A 3M5AA 3F9ZA 2JV0A 3M54A 3QWPA 4I51A 5KJMA 3F9YA 5CCMA 2W5ZA 3SW9A 4JDSA 4O30A 2R3AA 3TG5A 5LSZA 5KJLA 2IGQA 3S7FA 3QWWA 3RAYA 3IHXA 5F5EA 4IJ8A 5ARFA 3K5KA 1O9SA 3OS5A 5CPRB 4QENA 4Z4PA 5KJNA 1MVXA 4FMUA 4J8OA 4C1QA 5HQ8A 5EX0A 4QEOA 4QEPA 1MVHA 5F6LA 3CBPA 1PEGA 3MEKA 1XQHA 3MO0A 5T0MA 5EG2A 3CBOA 5LSXA 1ZKKA 3PDNA 4YNPA 5CCLA 3M58A 3N71A 4YPUA 4O6FA
chains in the Genus database with same CATH superfamily
4J7FA 4YPEA 1N6AA 3FPDA 3MO2A 4J83A 4JLGA 5T5GA 4MI5A 2F69A 2O8JA 3BO5A 5AYFA 4NVQA 3S7JA 4BUPA 3CBMA 3RU0A 3M56A 2W5YA 3OOIA 3VV0A 4YNMA 5HI7A 4MI0A 2RFIA 5JINA 3F9XA 3OXLA 1N3JA 3F9WA 3M55A 3DB5A 3KMTA 1H3IA 1MUFA 3EP0A 3S8PA 5KJKA 4E47A 4LDGA 4YNDA 3RJWA 1ML9A 3OXGA 1N6CA 5T0KA 3HNAA 3M59A 2BQZA 1MT6A 3KMAA 4YPAA 3SWCA 3OXFA 3M53A 3OPEA 3S7BA 5ARGA 3KMJA 3QWVA 5F59A 3S7DA 4NJ5A 3RIBA 3VUZA 5EX3A 5JJ0A 5JIYA 3M57A 3RQ4A 4IJDA 3TG4A 5F6KC 2QPWA 3DALA 4AU7A 5TH7A 4J7IA 5JHNA 5TEGA 4H12A 4RZ0A 3MO5A 5TTFA 4WUYA 2G46A 3M5AA 3F9ZA 2JV0A 3M54A 3QWPA 4I51A 5KJMA 3F9YA 5CCMA 2W5ZA 3SW9A 4JDSA 4O30A 2R3AA 3TG5A 5LSZA 5KJLA 2IGQA 3S7FA 3QWWA 3RAYA 3IHXA 5F5EA 4IJ8A 5ARFA 3K5KA 1O9SA 3OS5A 5CPRB 4QENA 4Z4PA 5KJNA 1MVXA 4FMUA 4J8OA 4C1QA 5HQ8A 5EX0A 4QEOA 4QEPA 1MVHA 5F6LA 3CBPA 1PEGA 3MEKA 1XQHA 3MO0A 5T0MA 5EG2A 3CBOA 5LSXA 1ZKKA 3PDNA 4YNPA 5CCLA 3M58A 3N71A 4YPUA 4O6FA
chains in the Genus database with same CATH topology
4J7FA 4YPEA 1N6AA 3FPDA 3MO2A 4J83A 4JLGA 5T5GA 4MI5A 2F69A 2O8JA 3BO5A 5AYFA 4NVQA 3S7JA 4BUPA 3CBMA 3RU0A 3M56A 2W5YA 3OOIA 3VV0A 4YNMA 5HI7A 4MI0A 2RFIA 5JINA 3F9XA 3OXLA 1N3JA 3F9WA 3M55A 3DB5A 3KMTA 1H3IA 1MUFA 3EP0A 3S8PA 5KJKA 4E47A 4LDGA 4YNDA 3RJWA 1ML9A 3OXGA 1N6CA 5T0KA 3HNAA 3M59A 2BQZA 1MT6A 3KMAA 4YPAA 3SWCA 3OXFA 3M53A 3OPEA 3S7BA 5ARGA 3KMJA 3QWVA 5F59A 3S7DA 4NJ5A 3RIBA 3VUZA 5EX3A 5JJ0A 5JIYA 3M57A 3RQ4A 4IJDA 3TG4A 5F6KC 2QPWA 3DALA 4AU7A 5TH7A 4J7IA 5JHNA 5TEGA 4H12A 4RZ0A 3MO5A 5TTFA 4WUYA 2G46A 3M5AA 3F9ZA 2JV0A 3M54A 3QWPA 4I51A 5KJMA 3F9YA 5CCMA 2W5ZA 3SW9A 4JDSA 4O30A 2R3AA 3TG5A 5LSZA 5KJLA 2IGQA 3S7FA 3QWWA 3RAYA 3IHXA 5F5EA 4IJ8A 5ARFA 3K5KA 1O9SA 3OS5A 5CPRB 4QENA 4Z4PA 5KJNA 1MVXA 4FMUA 4J8OA 4C1QA 5HQ8A 5EX0A 4QEOA 4QEPA 1MVHA 5F6LA 3CBPA 1PEGA 3MEKA 1XQHA 3MO0A 5T0MA 5EG2A 3CBOA 5LSXA 1ZKKA 3PDNA 4YNPA 5CCLA 3M58A 3N71A 4YPUA 4O6FA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4J7F A;  4YPE A;  1N6A A;  3FPD A;  3MO2 A;  4J83 A;  4JLG A;  5T5G A;  4MI5 A;  2F69 A;  2O8J A;  3BO5 A;  5AYF A;  4NVQ A;  3S7J A;  4BUP A;  3CBM A;  3RU0 A;  3M56 A;  2W5Y A;  3OOI A;  3VV0 A;  4YNM A;  5HI7 A;  4MI0 A;  2RFI A;  5JIN A;  3F9X A;  3OXL A;  1N3J A;  3F9W A;  3M55 A;  3DB5 A;  3KMT A;  1H3I A;  1MUF A;  3EP0 A;  3S8P A;  5KJK A;  4E47 A;  4LDG A;  4YND A;  3RJW A;  1ML9 A;  3OXG A;  1N6C A;  5T0K A;  3HNA A;  3M59 A;  2BQZ A;  1MT6 A;  3KMA A;  4YPA A;  3SWC A;  3OXF A;  3M53 A;  3OPE A;  3S7B A;  5ARG A;  3KMJ A;  3QWV A;  5F59 A;  3S7D A;  4NJ5 A;  3RIB A;  3VUZ A;  5EX3 A;  5JJ0 A;  5JIY A;  3M57 A;  3RQ4 A;  4IJD A;  3TG4 A;  5F6K C;  2QPW A;  3DAL A;  4AU7 A;  5TH7 A;  4J7I A;  5JHN A;  5TEG A;  4H12 A;  4RZ0 A;  3MO5 A;  5TTF A;  4WUY A;  2G46 A;  3M5A A;  3F9Z A;  2JV0 A;  3M54 A;  3QWP A;  4I51 A;  5KJM A;  3F9Y A;  5CCM A;  2W5Z A;  3SW9 A;  4JDS A;  4O30 A;  2R3A A;  3TG5 A;  5LSZ A;  5KJL A;  2IGQ A;  3S7F A;  3QWW A;  3RAY A;  3IHX A;  5F5E A;  4IJ8 A;  5ARF A;  3K5K A;  1O9S A;  3OS5 A;  5CPR B;  4QEN A;  4Z4P A;  5KJN A;  1MVX A;  4FMU A;  4J8O A;  4C1Q A;  5HQ8 A;  5EX0 A;  4QEO A;  4QEP A;  1MVH A;  5F6L A;  3CBP A;  1PEG A;  3MEK A;  1XQH A;  3MO0 A;  5T0M A;  5EG2 A;  3CBO A;  5LSX A;  1ZKK A;  3PDN A;  4YNP A;  5CCL A;  3M58 A;  3N71 A;  4YPU A;  4O6F A; 
#chains in the Genus database with same CATH topology
 4J7F A;  4YPE A;  1N6A A;  3FPD A;  3MO2 A;  4J83 A;  4JLG A;  5T5G A;  4MI5 A;  2F69 A;  2O8J A;  3BO5 A;  5AYF A;  4NVQ A;  3S7J A;  4BUP A;  3CBM A;  3RU0 A;  3M56 A;  2W5Y A;  3OOI A;  3VV0 A;  4YNM A;  5HI7 A;  4MI0 A;  2RFI A;  5JIN A;  3F9X A;  3OXL A;  1N3J A;  3F9W A;  3M55 A;  3DB5 A;  3KMT A;  1H3I A;  1MUF A;  3EP0 A;  3S8P A;  5KJK A;  4E47 A;  4LDG A;  4YND A;  3RJW A;  1ML9 A;  3OXG A;  1N6C A;  5T0K A;  3HNA A;  3M59 A;  2BQZ A;  1MT6 A;  3KMA A;  4YPA A;  3SWC A;  3OXF A;  3M53 A;  3OPE A;  3S7B A;  5ARG A;  3KMJ A;  3QWV A;  5F59 A;  3S7D A;  4NJ5 A;  3RIB A;  3VUZ A;  5EX3 A;  5JJ0 A;  5JIY A;  3M57 A;  3RQ4 A;  4IJD A;  3TG4 A;  5F6K C;  2QPW A;  3DAL A;  4AU7 A;  5TH7 A;  4J7I A;  5JHN A;  5TEG A;  4H12 A;  4RZ0 A;  3MO5 A;  5TTF A;  4WUY A;  2G46 A;  3M5A A;  3F9Z A;  2JV0 A;  3M54 A;  3QWP A;  4I51 A;  5KJM A;  3F9Y A;  5CCM A;  2W5Z A;  3SW9 A;  4JDS A;  4O30 A;  2R3A A;  3TG5 A;  5LSZ A;  5KJL A;  2IGQ A;  3S7F A;  3QWW A;  3RAY A;  3IHX A;  5F5E A;  4IJ8 A;  5ARF A;  3K5K A;  1O9S A;  3OS5 A;  5CPR B;  4QEN A;  4Z4P A;  5KJN A;  1MVX A;  4FMU A;  4J8O A;  4C1Q A;  5HQ8 A;  5EX0 A;  4QEO A;  4QEP A;  1MVH A;  5F6L A;  3CBP A;  1PEG A;  3MEK A;  1XQH A;  3MO0 A;  5T0M A;  5EG2 A;  3CBO A;  5LSX A;  1ZKK A;  3PDN A;  4YNP A;  5CCL A;  3M58 A;  3N71 A;  4YPU A;  4O6F A; 
#chains in the Genus database with same CATH homology
 4J7F A;  4YPE A;  1N6A A;  3FPD A;  3MO2 A;  4J83 A;  4JLG A;  5T5G A;  4MI5 A;  2F69 A;  2O8J A;  3BO5 A;  5AYF A;  4NVQ A;  3S7J A;  4BUP A;  3CBM A;  3RU0 A;  3M56 A;  2W5Y A;  3OOI A;  3VV0 A;  4YNM A;  5HI7 A;  4MI0 A;  2RFI A;  5JIN A;  3F9X A;  3OXL A;  1N3J A;  3F9W A;  3M55 A;  3DB5 A;  3KMT A;  1H3I A;  1MUF A;  3EP0 A;  3S8P A;  5KJK A;  4E47 A;  4LDG A;  4YND A;  3RJW A;  1ML9 A;  3OXG A;  1N6C A;  5T0K A;  3HNA A;  3M59 A;  2BQZ A;  1MT6 A;  3KMA A;  4YPA A;  3SWC A;  3OXF A;  3M53 A;  3OPE A;  3S7B A;  5ARG A;  3KMJ A;  3QWV A;  5F59 A;  3S7D A;  4NJ5 A;  3RIB A;  3VUZ A;  5EX3 A;  5JJ0 A;  5JIY A;  3M57 A;  3RQ4 A;  4IJD A;  3TG4 A;  5F6K C;  2QPW A;  3DAL A;  4AU7 A;  5TH7 A;  4J7I A;  5JHN A;  5TEG A;  4H12 A;  4RZ0 A;  3MO5 A;  5TTF A;  4WUY A;  2G46 A;  3M5A A;  3F9Z A;  2JV0 A;  3M54 A;  3QWP A;  4I51 A;  5KJM A;  3F9Y A;  5CCM A;  2W5Z A;  3SW9 A;  4JDS A;  4O30 A;  2R3A A;  3TG5 A;  5LSZ A;  5KJL A;  2IGQ A;  3S7F A;  3QWW A;  3RAY A;  3IHX A;  5F5E A;  4IJ8 A;  5ARF A;  3K5K A;  1O9S A;  3OS5 A;  5CPR B;  4QEN A;  4Z4P A;  5KJN A;  1MVX A;  4FMU A;  4J8O A;  4C1Q A;  5HQ8 A;  5EX0 A;  4QEO A;  4QEP A;  1MVH A;  5F6L A;  3CBP A;  1PEG A;  3MEK A;  1XQH A;  3MO0 A;  5T0M A;  5EG2 A;  3CBO A;  5LSX A;  1ZKK A;  3PDN A;  4YNP A;  5CCL A;  3M58 A;  3N71 A;  4YPU A;  4O6F A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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