5JINA

Structure of g9a set-domain with histone h3k9m mutant peptide and bound s-adenosylmethionine
Total Genus 77
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
77
sequence length
273
structure length
273
Chain Sequence
b'IRTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSR'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Histone-lysine N-methyltransferase EHMT2
publication title S-adenosyl methionine is necessary for inhibition of the methyltransferase G9a by the lysine 9 to methionine mutation on histone H3.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Transferase
total genus 77
structure length 273
sequence length 273
chains with identical sequence B
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2016-04-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF05033 Pre-SET Pre-SET motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 5jinA00
5JIYA 4E47A 5EX3A 5KJMA 5TEGA 1ZKKA 3S7FA 3QWWA 4O30A 4J7FA 3OS5A 4YPEA 5CCLA 2O8JA 3HNAA 5TH7A 3RIBA 3CBPA 1MUFA 4J83A 4NVQA 4J8OA 2IGQA 3RJWA 3IHXA 3DALA 3CBMA 3M57A 5F59A 1XQHA 3MO5A 3DB5A 3KMTA 5ARGA 2G46A 4Z4PA 5TTFA 5AYFA 3MEKA 4YPAA 4AU7A 3CBOA 2W5YA 2RFIA 5F6LA 4IJDA 4C1QA 3OOIA 3SW9A 4J7IA 4WUYA 5LSXA 5HQ8A 3F9YA 3M53A 5F6KC 4QEPA 3OXLA 4I51A 1ML9A 3S7BA 1N3JA 3M58A 4O6FA 5HI7A 3RU0A 4LDGA 3KMJA 3TG4A 5F5EA 3RQ4A 3EP0A 3M55A 2BQZA 5JJ0A 3S7DA 4FMUA 3M59A 4QENA 5T0KA 2R3AA 5CCMA 3F9ZA 3PDNA 5EX0A 4YNMA 3VV0A 3OXFA 5JINA 5T5GA 5CPRB 3OPEA 3QWVA 4YPUA 1MVXA 4YNPA 3S8PA 3SWCA 1O9SA 3RAYA 3M5AA 3M56A 5KJKA 4JDSA 1H3IA 2JV0A 4IJ8A 1PEGA 1N6AA 5EG2A 5KJNA 1MT6A 3MO2A 5T0MA 3KMAA 4MI5A 4MI0A 3BO5A 5KJLA 4YNDA 4QEOA 1N6CA 5LSZA 3N71A 3TG5A 5JHNA 3QWPA 4BUPA 3FPDA 1MVHA 3F9WA 2W5ZA 3OXGA 3VUZA 3S7JA 4RZ0A 2F69A 4NJ5A 5ARFA 3F9XA 2QPWA 3K5KA 3M54A 4H12A 4JLGA 3MO0A
chains in the Genus database with same CATH superfamily
5JIYA 4E47A 5EX3A 5KJMA 5TEGA 1ZKKA 3S7FA 3QWWA 4O30A 4J7FA 3OS5A 4YPEA 5CCLA 2O8JA 3HNAA 5TH7A 3RIBA 3CBPA 1MUFA 4J83A 4NVQA 4J8OA 2IGQA 3RJWA 3IHXA 3DALA 3CBMA 3M57A 5F59A 1XQHA 3MO5A 3DB5A 3KMTA 5ARGA 2G46A 4Z4PA 5TTFA 5AYFA 3MEKA 4YPAA 4AU7A 3CBOA 2W5YA 2RFIA 5F6LA 4IJDA 4C1QA 3OOIA 3SW9A 4J7IA 4WUYA 5LSXA 5HQ8A 3F9YA 3M53A 5F6KC 4QEPA 3OXLA 4I51A 1ML9A 3S7BA 1N3JA 3M58A 4O6FA 5HI7A 3RU0A 4LDGA 3KMJA 3TG4A 5F5EA 3RQ4A 3EP0A 3M55A 2BQZA 5JJ0A 3S7DA 4FMUA 3M59A 4QENA 5T0KA 2R3AA 5CCMA 3F9ZA 3PDNA 5EX0A 4YNMA 3VV0A 3OXFA 5JINA 5T5GA 5CPRB 3OPEA 3QWVA 4YPUA 1MVXA 4YNPA 3S8PA 3SWCA 1O9SA 3RAYA 3M5AA 3M56A 5KJKA 4JDSA 1H3IA 2JV0A 4IJ8A 1PEGA 1N6AA 5EG2A 5KJNA 1MT6A 3MO2A 5T0MA 3KMAA 4MI5A 4MI0A 3BO5A 5KJLA 4YNDA 4QEOA 1N6CA 5LSZA 3N71A 3TG5A 5JHNA 3QWPA 4BUPA 3FPDA 1MVHA 3F9WA 2W5ZA 3OXGA 3VUZA 3S7JA 4RZ0A 2F69A 4NJ5A 5ARFA 3F9XA 2QPWA 3K5KA 3M54A 4H12A 4JLGA 3MO0A
chains in the Genus database with same CATH topology
5JIYA 4E47A 5EX3A 5KJMA 5TEGA 1ZKKA 3S7FA 3QWWA 4O30A 4J7FA 3OS5A 4YPEA 5CCLA 2O8JA 3HNAA 5TH7A 3RIBA 3CBPA 1MUFA 4J83A 4NVQA 4J8OA 2IGQA 3RJWA 3IHXA 3DALA 3CBMA 3M57A 5F59A 1XQHA 3MO5A 3DB5A 3KMTA 5ARGA 2G46A 4Z4PA 5TTFA 5AYFA 3MEKA 4YPAA 4AU7A 3CBOA 2W5YA 2RFIA 5F6LA 4IJDA 4C1QA 3OOIA 3SW9A 4J7IA 4WUYA 5LSXA 5HQ8A 3F9YA 3M53A 5F6KC 4QEPA 3OXLA 4I51A 1ML9A 3S7BA 1N3JA 3M58A 4O6FA 5HI7A 3RU0A 4LDGA 3KMJA 3TG4A 5F5EA 3RQ4A 3EP0A 3M55A 2BQZA 5JJ0A 3S7DA 4FMUA 3M59A 4QENA 5T0KA 2R3AA 5CCMA 3F9ZA 3PDNA 5EX0A 4YNMA 3VV0A 3OXFA 5JINA 5T5GA 5CPRB 3OPEA 3QWVA 4YPUA 1MVXA 4YNPA 3S8PA 3SWCA 1O9SA 3RAYA 3M5AA 3M56A 5KJKA 4JDSA 1H3IA 2JV0A 4IJ8A 1PEGA 1N6AA 5EG2A 5KJNA 1MT6A 3MO2A 5T0MA 3KMAA 4MI5A 4MI0A 3BO5A 5KJLA 4YNDA 4QEOA 1N6CA 5LSZA 3N71A 3TG5A 5JHNA 3QWPA 4BUPA 3FPDA 1MVHA 3F9WA 2W5ZA 3OXGA 3VUZA 3S7JA 4RZ0A 2F69A 4NJ5A 5ARFA 3F9XA 2QPWA 3K5KA 3M54A 4H12A 4JLGA 3MO0A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5JIY A;  4E47 A;  5EX3 A;  5KJM A;  5TEG A;  1ZKK A;  3S7F A;  3QWW A;  4O30 A;  4J7F A;  3OS5 A;  4YPE A;  5CCL A;  2O8J A;  3HNA A;  5TH7 A;  3RIB A;  3CBP A;  1MUF A;  4J83 A;  4NVQ A;  4J8O A;  2IGQ A;  3RJW A;  3IHX A;  3DAL A;  3CBM A;  3M57 A;  5F59 A;  1XQH A;  3MO5 A;  3DB5 A;  3KMT A;  5ARG A;  2G46 A;  4Z4P A;  5TTF A;  5AYF A;  3MEK A;  4YPA A;  4AU7 A;  3CBO A;  2W5Y A;  2RFI A;  5F6L A;  4IJD A;  4C1Q A;  3OOI A;  3SW9 A;  4J7I A;  4WUY A;  5LSX A;  5HQ8 A;  3F9Y A;  3M53 A;  5F6K C;  4QEP A;  3OXL A;  4I51 A;  1ML9 A;  3S7B A;  1N3J A;  3M58 A;  4O6F A;  5HI7 A;  3RU0 A;  4LDG A;  3KMJ A;  3TG4 A;  5F5E A;  3RQ4 A;  3EP0 A;  3M55 A;  2BQZ A;  5JJ0 A;  3S7D A;  4FMU A;  3M59 A;  4QEN A;  5T0K A;  2R3A A;  5CCM A;  3F9Z A;  3PDN A;  5EX0 A;  4YNM A;  3VV0 A;  3OXF A;  5JIN A;  5T5G A;  5CPR B;  3OPE A;  3QWV A;  4YPU A;  1MVX A;  4YNP A;  3S8P A;  3SWC A;  1O9S A;  3RAY A;  3M5A A;  3M56 A;  5KJK A;  4JDS A;  1H3I A;  2JV0 A;  4IJ8 A;  1PEG A;  1N6A A;  5EG2 A;  5KJN A;  1MT6 A;  3MO2 A;  5T0M A;  3KMA A;  4MI5 A;  4MI0 A;  3BO5 A;  5KJL A;  4YND A;  4QEO A;  1N6C A;  5LSZ A;  3N71 A;  3TG5 A;  5JHN A;  3QWP A;  4BUP A;  3FPD A;  1MVH A;  3F9W A;  2W5Z A;  3OXG A;  3VUZ A;  3S7J A;  4RZ0 A;  2F69 A;  4NJ5 A;  5ARF A;  3F9X A;  2QPW A;  3K5K A;  3M54 A;  4H12 A;  4JLG A;  3MO0 A; 
#chains in the Genus database with same CATH topology
 5JIY A;  4E47 A;  5EX3 A;  5KJM A;  5TEG A;  1ZKK A;  3S7F A;  3QWW A;  4O30 A;  4J7F A;  3OS5 A;  4YPE A;  5CCL A;  2O8J A;  3HNA A;  5TH7 A;  3RIB A;  3CBP A;  1MUF A;  4J83 A;  4NVQ A;  4J8O A;  2IGQ A;  3RJW A;  3IHX A;  3DAL A;  3CBM A;  3M57 A;  5F59 A;  1XQH A;  3MO5 A;  3DB5 A;  3KMT A;  5ARG A;  2G46 A;  4Z4P A;  5TTF A;  5AYF A;  3MEK A;  4YPA A;  4AU7 A;  3CBO A;  2W5Y A;  2RFI A;  5F6L A;  4IJD A;  4C1Q A;  3OOI A;  3SW9 A;  4J7I A;  4WUY A;  5LSX A;  5HQ8 A;  3F9Y A;  3M53 A;  5F6K C;  4QEP A;  3OXL A;  4I51 A;  1ML9 A;  3S7B A;  1N3J A;  3M58 A;  4O6F A;  5HI7 A;  3RU0 A;  4LDG A;  3KMJ A;  3TG4 A;  5F5E A;  3RQ4 A;  3EP0 A;  3M55 A;  2BQZ A;  5JJ0 A;  3S7D A;  4FMU A;  3M59 A;  4QEN A;  5T0K A;  2R3A A;  5CCM A;  3F9Z A;  3PDN A;  5EX0 A;  4YNM A;  3VV0 A;  3OXF A;  5JIN A;  5T5G A;  5CPR B;  3OPE A;  3QWV A;  4YPU A;  1MVX A;  4YNP A;  3S8P A;  3SWC A;  1O9S A;  3RAY A;  3M5A A;  3M56 A;  5KJK A;  4JDS A;  1H3I A;  2JV0 A;  4IJ8 A;  1PEG A;  1N6A A;  5EG2 A;  5KJN A;  1MT6 A;  3MO2 A;  5T0M A;  3KMA A;  4MI5 A;  4MI0 A;  3BO5 A;  5KJL A;  4YND A;  4QEO A;  1N6C A;  5LSZ A;  3N71 A;  3TG5 A;  5JHN A;  3QWP A;  4BUP A;  3FPD A;  1MVH A;  3F9W A;  2W5Z A;  3OXG A;  3VUZ A;  3S7J A;  4RZ0 A;  2F69 A;  4NJ5 A;  5ARF A;  3F9X A;  2QPW A;  3K5K A;  3M54 A;  4H12 A;  4JLG A;  3MO0 A; 
#chains in the Genus database with same CATH homology
 5JIY A;  4E47 A;  5EX3 A;  5KJM A;  5TEG A;  1ZKK A;  3S7F A;  3QWW A;  4O30 A;  4J7F A;  3OS5 A;  4YPE A;  5CCL A;  2O8J A;  3HNA A;  5TH7 A;  3RIB A;  3CBP A;  1MUF A;  4J83 A;  4NVQ A;  4J8O A;  2IGQ A;  3RJW A;  3IHX A;  3DAL A;  3CBM A;  3M57 A;  5F59 A;  1XQH A;  3MO5 A;  3DB5 A;  3KMT A;  5ARG A;  2G46 A;  4Z4P A;  5TTF A;  5AYF A;  3MEK A;  4YPA A;  4AU7 A;  3CBO A;  2W5Y A;  2RFI A;  5F6L A;  4IJD A;  4C1Q A;  3OOI A;  3SW9 A;  4J7I A;  4WUY A;  5LSX A;  5HQ8 A;  3F9Y A;  3M53 A;  5F6K C;  4QEP A;  3OXL A;  4I51 A;  1ML9 A;  3S7B A;  1N3J A;  3M58 A;  4O6F A;  5HI7 A;  3RU0 A;  4LDG A;  3KMJ A;  3TG4 A;  5F5E A;  3RQ4 A;  3EP0 A;  3M55 A;  2BQZ A;  5JJ0 A;  3S7D A;  4FMU A;  3M59 A;  4QEN A;  5T0K A;  2R3A A;  5CCM A;  3F9Z A;  3PDN A;  5EX0 A;  4YNM A;  3VV0 A;  3OXF A;  5JIN A;  5T5G A;  5CPR B;  3OPE A;  3QWV A;  4YPU A;  1MVX A;  4YNP A;  3S8P A;  3SWC A;  1O9S A;  3RAY A;  3M5A A;  3M56 A;  5KJK A;  4JDS A;  1H3I A;  2JV0 A;  4IJ8 A;  1PEG A;  1N6A A;  5EG2 A;  5KJN A;  1MT6 A;  3MO2 A;  5T0M A;  3KMA A;  4MI5 A;  4MI0 A;  3BO5 A;  5KJL A;  4YND A;  4QEO A;  1N6C A;  5LSZ A;  3N71 A;  3TG5 A;  5JHN A;  3QWP A;  4BUP A;  3FPD A;  1MVH A;  3F9W A;  2W5Z A;  3OXG A;  3VUZ A;  3S7J A;  4RZ0 A;  2F69 A;  4NJ5 A;  5ARF A;  3F9X A;  2QPW A;  3K5K A;  3M54 A;  4H12 A;  4JLG A;  3MO0 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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