5JINA

Structure of g9a set-domain with histone h3k9m mutant peptide and bound s-adenosylmethionine
Total Genus 77
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
77
sequence length
273
structure length
273
Chain Sequence
IRTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSR
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title S-adenosyl methionine is necessary for inhibition of the methyltransferase G9a by the lysine 9 to methionine mutation on histone H3.
pubmed doi rcsb
molecule keywords Histone-lysine N-methyltransferase EHMT2
molecule tags Transferase
source organism Homo sapiens
total genus 77
structure length 273
sequence length 273
chains with identical sequence B
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2016-04-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF05033 Pre-SET Pre-SET motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 5jinA00
4MI5A 4NVQA 3RJWA 3S8PA 4WUYA 5ARFA 4YPEA 4FMUA 3OOIA 5KJNA 3TG4A 5EX0A 3BO5A 4I51A 3HNAA 4O6FA 3FPDA 2IGQA 5HQ8A 4J8OA 3DB5A 1N6CA 4IJDA 3M59A 1ZKKA 3RU0A 1MVXA 3OPEA 5EG2A 5T0MA 2F69A 3MEKA 4MI0A 4QEPA 1MUFA 3DALA 3N71A 3S7JA 5TEGA 4RZ0A 3M55A 5T0KA 3M57A 3KMTA 3OXLA 3MO5A 5TTFA 3MO0A 4YNMA 3F9WA 4YPAA 5HI7A 3TG5A 3OXGA 4IJ8A 3QWWA 3IHXA 3RQ4A 4J7IA 5F6KC 3CBOA 3MO2A 5LSXA 5JHNA 4YPUA 3S7BA 2W5ZA 3F9XA 5KJLA 1N6AA 2RFIA 3CBMA 1XQHA 4JLGA 1N3JA 5CPRB 5CCLA 1O9SA 4H12A 4E47A 5TH7A 3RAYA 3KMJA 5LSZA 4NJ5A 4Z4PA 3RIBA 5JIYA 4YNPA 3VV0A 4O30A 1H3IA 2JV0A 3F9ZA 3S7DA 3S7FA 3SWCA 5KJKA 4YNDA 5JINA 3K5KA 2G46A 1PEGA 5ARGA 4J83A 5JJ0A 3EP0A 3KMAA 1ML9A 4LDGA 3M56A 4QEOA 3VUZA 3OS5A 5CCMA 3M5AA 2R3AA 5T5GA 5KJMA 3M53A 4J7FA 2BQZA 3QWPA 4BUPA 5F5EA 5F6LA 3OXFA 4QENA 3PDNA 3QWVA 5F59A 3F9YA 2W5YA 4C1QA 2QPWA 5EX3A 3M58A 3CBPA 4AU7A 4JDSA 1MVHA 1MT6A 5AYFA 2O8JA 3M54A 3SW9A
chains in the Genus database with same CATH superfamily
4MI5A 4NVQA 3RJWA 3S8PA 4WUYA 5ARFA 4YPEA 4FMUA 3OOIA 5KJNA 3TG4A 5EX0A 3BO5A 4I51A 3HNAA 4O6FA 3FPDA 2IGQA 5HQ8A 4J8OA 3DB5A 1N6CA 4IJDA 3M59A 1ZKKA 3RU0A 1MVXA 3OPEA 5EG2A 5T0MA 2F69A 3MEKA 4MI0A 4QEPA 1MUFA 3DALA 3N71A 3S7JA 5TEGA 4RZ0A 3M55A 5T0KA 3M57A 3KMTA 3OXLA 3MO5A 5TTFA 3MO0A 4YNMA 3F9WA 4YPAA 5HI7A 3TG5A 3OXGA 4IJ8A 3QWWA 3IHXA 3RQ4A 4J7IA 5F6KC 3CBOA 3MO2A 5LSXA 5JHNA 4YPUA 3S7BA 2W5ZA 3F9XA 5KJLA 1N6AA 2RFIA 3CBMA 1XQHA 4JLGA 1N3JA 5CPRB 5CCLA 1O9SA 4H12A 4E47A 5TH7A 3RAYA 3KMJA 5LSZA 4NJ5A 4Z4PA 3RIBA 5JIYA 4YNPA 3VV0A 4O30A 1H3IA 2JV0A 3F9ZA 3S7DA 3S7FA 3SWCA 5KJKA 4YNDA 5JINA 3K5KA 2G46A 1PEGA 5ARGA 4J83A 5JJ0A 3EP0A 3KMAA 1ML9A 4LDGA 3M56A 4QEOA 3VUZA 3OS5A 5CCMA 3M5AA 2R3AA 5T5GA 5KJMA 3M53A 4J7FA 2BQZA 3QWPA 4BUPA 5F5EA 5F6LA 3OXFA 4QENA 3PDNA 3QWVA 5F59A 3F9YA 2W5YA 4C1QA 2QPWA 5EX3A 3M58A 3CBPA 4AU7A 4JDSA 1MVHA 1MT6A 5AYFA 2O8JA 3M54A 3SW9A
chains in the Genus database with same CATH topology
4MI5A 4NVQA 3RJWA 3S8PA 4WUYA 5ARFA 4YPEA 4FMUA 3OOIA 5KJNA 3TG4A 5EX0A 3BO5A 4I51A 3HNAA 4O6FA 3FPDA 2IGQA 5HQ8A 4J8OA 3DB5A 1N6CA 4IJDA 3M59A 1ZKKA 3RU0A 1MVXA 3OPEA 5EG2A 5T0MA 2F69A 3MEKA 4MI0A 4QEPA 1MUFA 3DALA 3N71A 3S7JA 5TEGA 4RZ0A 3M55A 5T0KA 3M57A 3KMTA 3OXLA 3MO5A 5TTFA 3MO0A 4YNMA 3F9WA 4YPAA 5HI7A 3TG5A 3OXGA 4IJ8A 3QWWA 3IHXA 3RQ4A 4J7IA 5F6KC 3CBOA 3MO2A 5LSXA 5JHNA 4YPUA 3S7BA 2W5ZA 3F9XA 5KJLA 1N6AA 2RFIA 3CBMA 1XQHA 4JLGA 1N3JA 5CPRB 5CCLA 1O9SA 4H12A 4E47A 5TH7A 3RAYA 3KMJA 5LSZA 4NJ5A 4Z4PA 3RIBA 5JIYA 4YNPA 3VV0A 4O30A 1H3IA 2JV0A 3F9ZA 3S7DA 3S7FA 3SWCA 5KJKA 4YNDA 5JINA 3K5KA 2G46A 1PEGA 5ARGA 4J83A 5JJ0A 3EP0A 3KMAA 1ML9A 4LDGA 3M56A 4QEOA 3VUZA 3OS5A 5CCMA 3M5AA 2R3AA 5T5GA 5KJMA 3M53A 4J7FA 2BQZA 3QWPA 4BUPA 5F5EA 5F6LA 3OXFA 4QENA 3PDNA 3QWVA 5F59A 3F9YA 2W5YA 4C1QA 2QPWA 5EX3A 3M58A 3CBPA 4AU7A 4JDSA 1MVHA 1MT6A 5AYFA 2O8JA 3M54A 3SW9A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4MI5 A;  4NVQ A;  3RJW A;  3S8P A;  4WUY A;  5ARF A;  4YPE A;  4FMU A;  3OOI A;  5KJN A;  3TG4 A;  5EX0 A;  3BO5 A;  4I51 A;  3HNA A;  4O6F A;  3FPD A;  2IGQ A;  5HQ8 A;  4J8O A;  3DB5 A;  1N6C A;  4IJD A;  3M59 A;  1ZKK A;  3RU0 A;  1MVX A;  3OPE A;  5EG2 A;  5T0M A;  2F69 A;  3MEK A;  4MI0 A;  4QEP A;  1MUF A;  3DAL A;  3N71 A;  3S7J A;  5TEG A;  4RZ0 A;  3M55 A;  5T0K A;  3M57 A;  3KMT A;  3OXL A;  3MO5 A;  5TTF A;  3MO0 A;  4YNM A;  3F9W A;  4YPA A;  5HI7 A;  3TG5 A;  3OXG A;  4IJ8 A;  3QWW A;  3IHX A;  3RQ4 A;  4J7I A;  5F6K C;  3CBO A;  3MO2 A;  5LSX A;  5JHN A;  4YPU A;  3S7B A;  2W5Z A;  3F9X A;  5KJL A;  1N6A A;  2RFI A;  3CBM A;  1XQH A;  4JLG A;  1N3J A;  5CPR B;  5CCL A;  1O9S A;  4H12 A;  4E47 A;  5TH7 A;  3RAY A;  3KMJ A;  5LSZ A;  4NJ5 A;  4Z4P A;  3RIB A;  5JIY A;  4YNP A;  3VV0 A;  4O30 A;  1H3I A;  2JV0 A;  3F9Z A;  3S7D A;  3S7F A;  3SWC A;  5KJK A;  4YND A;  5JIN A;  3K5K A;  2G46 A;  1PEG A;  5ARG A;  4J83 A;  5JJ0 A;  3EP0 A;  3KMA A;  1ML9 A;  4LDG A;  3M56 A;  4QEO A;  3VUZ A;  3OS5 A;  5CCM A;  3M5A A;  2R3A A;  5T5G A;  5KJM A;  3M53 A;  4J7F A;  2BQZ A;  3QWP A;  4BUP A;  5F5E A;  5F6L A;  3OXF A;  4QEN A;  3PDN A;  3QWV A;  5F59 A;  3F9Y A;  2W5Y A;  4C1Q A;  2QPW A;  5EX3 A;  3M58 A;  3CBP A;  4AU7 A;  4JDS A;  1MVH A;  1MT6 A;  5AYF A;  2O8J A;  3M54 A;  3SW9 A; 
#chains in the Genus database with same CATH topology
 4MI5 A;  4NVQ A;  3RJW A;  3S8P A;  4WUY A;  5ARF A;  4YPE A;  4FMU A;  3OOI A;  5KJN A;  3TG4 A;  5EX0 A;  3BO5 A;  4I51 A;  3HNA A;  4O6F A;  3FPD A;  2IGQ A;  5HQ8 A;  4J8O A;  3DB5 A;  1N6C A;  4IJD A;  3M59 A;  1ZKK A;  3RU0 A;  1MVX A;  3OPE A;  5EG2 A;  5T0M A;  2F69 A;  3MEK A;  4MI0 A;  4QEP A;  1MUF A;  3DAL A;  3N71 A;  3S7J A;  5TEG A;  4RZ0 A;  3M55 A;  5T0K A;  3M57 A;  3KMT A;  3OXL A;  3MO5 A;  5TTF A;  3MO0 A;  4YNM A;  3F9W A;  4YPA A;  5HI7 A;  3TG5 A;  3OXG A;  4IJ8 A;  3QWW A;  3IHX A;  3RQ4 A;  4J7I A;  5F6K C;  3CBO A;  3MO2 A;  5LSX A;  5JHN A;  4YPU A;  3S7B A;  2W5Z A;  3F9X A;  5KJL A;  1N6A A;  2RFI A;  3CBM A;  1XQH A;  4JLG A;  1N3J A;  5CPR B;  5CCL A;  1O9S A;  4H12 A;  4E47 A;  5TH7 A;  3RAY A;  3KMJ A;  5LSZ A;  4NJ5 A;  4Z4P A;  3RIB A;  5JIY A;  4YNP A;  3VV0 A;  4O30 A;  1H3I A;  2JV0 A;  3F9Z A;  3S7D A;  3S7F A;  3SWC A;  5KJK A;  4YND A;  5JIN A;  3K5K A;  2G46 A;  1PEG A;  5ARG A;  4J83 A;  5JJ0 A;  3EP0 A;  3KMA A;  1ML9 A;  4LDG A;  3M56 A;  4QEO A;  3VUZ A;  3OS5 A;  5CCM A;  3M5A A;  2R3A A;  5T5G A;  5KJM A;  3M53 A;  4J7F A;  2BQZ A;  3QWP A;  4BUP A;  5F5E A;  5F6L A;  3OXF A;  4QEN A;  3PDN A;  3QWV A;  5F59 A;  3F9Y A;  2W5Y A;  4C1Q A;  2QPW A;  5EX3 A;  3M58 A;  3CBP A;  4AU7 A;  4JDS A;  1MVH A;  1MT6 A;  5AYF A;  2O8J A;  3M54 A;  3SW9 A; 
#chains in the Genus database with same CATH homology
 4MI5 A;  4NVQ A;  3RJW A;  3S8P A;  4WUY A;  5ARF A;  4YPE A;  4FMU A;  3OOI A;  5KJN A;  3TG4 A;  5EX0 A;  3BO5 A;  4I51 A;  3HNA A;  4O6F A;  3FPD A;  2IGQ A;  5HQ8 A;  4J8O A;  3DB5 A;  1N6C A;  4IJD A;  3M59 A;  1ZKK A;  3RU0 A;  1MVX A;  3OPE A;  5EG2 A;  5T0M A;  2F69 A;  3MEK A;  4MI0 A;  4QEP A;  1MUF A;  3DAL A;  3N71 A;  3S7J A;  5TEG A;  4RZ0 A;  3M55 A;  5T0K A;  3M57 A;  3KMT A;  3OXL A;  3MO5 A;  5TTF A;  3MO0 A;  4YNM A;  3F9W A;  4YPA A;  5HI7 A;  3TG5 A;  3OXG A;  4IJ8 A;  3QWW A;  3IHX A;  3RQ4 A;  4J7I A;  5F6K C;  3CBO A;  3MO2 A;  5LSX A;  5JHN A;  4YPU A;  3S7B A;  2W5Z A;  3F9X A;  5KJL A;  1N6A A;  2RFI A;  3CBM A;  1XQH A;  4JLG A;  1N3J A;  5CPR B;  5CCL A;  1O9S A;  4H12 A;  4E47 A;  5TH7 A;  3RAY A;  3KMJ A;  5LSZ A;  4NJ5 A;  4Z4P A;  3RIB A;  5JIY A;  4YNP A;  3VV0 A;  4O30 A;  1H3I A;  2JV0 A;  3F9Z A;  3S7D A;  3S7F A;  3SWC A;  5KJK A;  4YND A;  5JIN A;  3K5K A;  2G46 A;  1PEG A;  5ARG A;  4J83 A;  5JJ0 A;  3EP0 A;  3KMA A;  1ML9 A;  4LDG A;  3M56 A;  4QEO A;  3VUZ A;  3OS5 A;  5CCM A;  3M5A A;  2R3A A;  5T5G A;  5KJM A;  3M53 A;  4J7F A;  2BQZ A;  3QWP A;  4BUP A;  5F5E A;  5F6L A;  3OXF A;  4QEN A;  3PDN A;  3QWV A;  5F59 A;  3F9Y A;  2W5Y A;  4C1Q A;  2QPW A;  5EX3 A;  3M58 A;  3CBP A;  4AU7 A;  4JDS A;  1MVH A;  1MT6 A;  5AYF A;  2O8J A;  3M54 A;  3SW9 A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...