4I51A

Methyltransferase domain of human euchromatic histone methyltransferase 1, mutant y1211a
Total Genus 69
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
69
sequence length
261
structure length
261
Chain Sequence
VERIVSRDIARGYERIPIPCVNAVDSEPCPSNYKYVSQNCVTSPMNIDRNITHLQYCVCIDDCSSSNCMCGQLSMRCWYDKDGRLLPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLDNKDGEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDAGERFWDIKGKLFSCRCGSPKCRHS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Histone-lysine N-methyltransferase EHMT1
publication title Defining efficient enzyme-cofactor pairs for bioorthogonal profiling of protein methylation.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Transferase/peptide
total genus 69
structure length 261
sequence length 261
chains with identical sequence B
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2012-11-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF05033 Pre-SET Pre-SET motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 4i51A00
3QWVA 2O8JA 4QEOA 4H12A 4JLGA 3M54A 3F9YA 1XQHA 3RIBA 5CCMA 4IJDA 5KJLA 3OXLA 5JIYA 4AU7A 4Z4PA 1N6CA 5T0KA 3RU0A 3RJWA 4YNPA 4FMUA 5HI7A 5KJMA 3DB5A 4J7FA 5JHNA 3VUZA 5ARGA 5JINA 5T0MA 5EX3A 5TH7A 3FPDA 3SW9A 4BUPA 4YPUA 4O6FA 3RQ4A 5F6KC 1MVXA 4NJ5A 3QWPA 3TG5A 3MEKA 3MO5A 5F5EA 2BQZA 5JJ0A 2QPWA 1PEGA 3OOIA 5LSXA 3F9WA 5KJNA 3OS5A 3MO0A 3N71A 1MUFA 4J83A 4YPEA 4O30A 4MI5A 5LSZA 3K5KA 5ARFA 3M59A 4J8OA 4RZ0A 4E47A 1ML9A 2W5ZA 3DALA 5CCLA 5AYFA 3KMTA 5F59A 4IJ8A 4JDSA 3S7FA 3M53A 3OXFA 3TG4A 3MO2A 3F9XA 4QENA 5EX0A 3S7JA 4I51A 3CBPA 3M5AA 1MVHA 4YPAA 3PDNA 3M55A 4MI0A 4J7IA 5CPRB 2W5YA 3OXGA 3KMAA 5TTFA 1O9SA 3M56A 1MT6A 5EG2A 3CBMA 3RAYA 3S7BA 3IHXA 3S7DA 5TEGA 2RFIA 4LDGA 5F6LA 5KJKA 1N3JA 3BO5A 2F69A 4YNMA 3QWWA 3VV0A 3SWCA 2IGQA 4NVQA 4QEPA 4YNDA 3CBOA 3EP0A 4C1QA 5HQ8A 3HNAA 2R3AA 2JV0A 3M57A 3OPEA 1N6AA 1H3IA 5T5GA 3S8PA 1ZKKA 3KMJA 3F9ZA 2G46A 3M58A 4WUYA
chains in the Genus database with same CATH superfamily
3QWVA 2O8JA 4QEOA 4H12A 4JLGA 3M54A 3F9YA 1XQHA 3RIBA 5CCMA 4IJDA 5KJLA 3OXLA 5JIYA 4AU7A 4Z4PA 1N6CA 5T0KA 3RU0A 3RJWA 4YNPA 4FMUA 5HI7A 5KJMA 3DB5A 4J7FA 5JHNA 3VUZA 5ARGA 5JINA 5T0MA 5EX3A 5TH7A 3FPDA 3SW9A 4BUPA 4YPUA 4O6FA 3RQ4A 5F6KC 1MVXA 4NJ5A 3QWPA 3TG5A 3MEKA 3MO5A 5F5EA 2BQZA 5JJ0A 2QPWA 1PEGA 3OOIA 5LSXA 3F9WA 5KJNA 3OS5A 3MO0A 3N71A 1MUFA 4J83A 4YPEA 4O30A 4MI5A 5LSZA 3K5KA 5ARFA 3M59A 4J8OA 4RZ0A 4E47A 1ML9A 2W5ZA 3DALA 5CCLA 5AYFA 3KMTA 5F59A 4IJ8A 4JDSA 3S7FA 3M53A 3OXFA 3TG4A 3MO2A 3F9XA 4QENA 5EX0A 3S7JA 4I51A 3CBPA 3M5AA 1MVHA 4YPAA 3PDNA 3M55A 4MI0A 4J7IA 5CPRB 2W5YA 3OXGA 3KMAA 5TTFA 1O9SA 3M56A 1MT6A 5EG2A 3CBMA 3RAYA 3S7BA 3IHXA 3S7DA 5TEGA 2RFIA 4LDGA 5F6LA 5KJKA 1N3JA 3BO5A 2F69A 4YNMA 3QWWA 3VV0A 3SWCA 2IGQA 4NVQA 4QEPA 4YNDA 3CBOA 3EP0A 4C1QA 5HQ8A 3HNAA 2R3AA 2JV0A 3M57A 3OPEA 1N6AA 1H3IA 5T5GA 3S8PA 1ZKKA 3KMJA 3F9ZA 2G46A 3M58A 4WUYA
chains in the Genus database with same CATH topology
3QWVA 2O8JA 4QEOA 4H12A 4JLGA 3M54A 3F9YA 1XQHA 3RIBA 5CCMA 4IJDA 5KJLA 3OXLA 5JIYA 4AU7A 4Z4PA 1N6CA 5T0KA 3RU0A 3RJWA 4YNPA 4FMUA 5HI7A 5KJMA 3DB5A 4J7FA 5JHNA 3VUZA 5ARGA 5JINA 5T0MA 5EX3A 5TH7A 3FPDA 3SW9A 4BUPA 4YPUA 4O6FA 3RQ4A 5F6KC 1MVXA 4NJ5A 3QWPA 3TG5A 3MEKA 3MO5A 5F5EA 2BQZA 5JJ0A 2QPWA 1PEGA 3OOIA 5LSXA 3F9WA 5KJNA 3OS5A 3MO0A 3N71A 1MUFA 4J83A 4YPEA 4O30A 4MI5A 5LSZA 3K5KA 5ARFA 3M59A 4J8OA 4RZ0A 4E47A 1ML9A 2W5ZA 3DALA 5CCLA 5AYFA 3KMTA 5F59A 4IJ8A 4JDSA 3S7FA 3M53A 3OXFA 3TG4A 3MO2A 3F9XA 4QENA 5EX0A 3S7JA 4I51A 3CBPA 3M5AA 1MVHA 4YPAA 3PDNA 3M55A 4MI0A 4J7IA 5CPRB 2W5YA 3OXGA 3KMAA 5TTFA 1O9SA 3M56A 1MT6A 5EG2A 3CBMA 3RAYA 3S7BA 3IHXA 3S7DA 5TEGA 2RFIA 4LDGA 5F6LA 5KJKA 1N3JA 3BO5A 2F69A 4YNMA 3QWWA 3VV0A 3SWCA 2IGQA 4NVQA 4QEPA 4YNDA 3CBOA 3EP0A 4C1QA 5HQ8A 3HNAA 2R3AA 2JV0A 3M57A 3OPEA 1N6AA 1H3IA 5T5GA 3S8PA 1ZKKA 3KMJA 3F9ZA 2G46A 3M58A 4WUYA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3QWV A;  2O8J A;  4QEO A;  4H12 A;  4JLG A;  3M54 A;  3F9Y A;  1XQH A;  3RIB A;  5CCM A;  4IJD A;  5KJL A;  3OXL A;  5JIY A;  4AU7 A;  4Z4P A;  1N6C A;  5T0K A;  3RU0 A;  3RJW A;  4YNP A;  4FMU A;  5HI7 A;  5KJM A;  3DB5 A;  4J7F A;  5JHN A;  3VUZ A;  5ARG A;  5JIN A;  5T0M A;  5EX3 A;  5TH7 A;  3FPD A;  3SW9 A;  4BUP A;  4YPU A;  4O6F A;  3RQ4 A;  5F6K C;  1MVX A;  4NJ5 A;  3QWP A;  3TG5 A;  3MEK A;  3MO5 A;  5F5E A;  2BQZ A;  5JJ0 A;  2QPW A;  1PEG A;  3OOI A;  5LSX A;  3F9W A;  5KJN A;  3OS5 A;  3MO0 A;  3N71 A;  1MUF A;  4J83 A;  4YPE A;  4O30 A;  4MI5 A;  5LSZ A;  3K5K A;  5ARF A;  3M59 A;  4J8O A;  4RZ0 A;  4E47 A;  1ML9 A;  2W5Z A;  3DAL A;  5CCL A;  5AYF A;  3KMT A;  5F59 A;  4IJ8 A;  4JDS A;  3S7F A;  3M53 A;  3OXF A;  3TG4 A;  3MO2 A;  3F9X A;  4QEN A;  5EX0 A;  3S7J A;  4I51 A;  3CBP A;  3M5A A;  1MVH A;  4YPA A;  3PDN A;  3M55 A;  4MI0 A;  4J7I A;  5CPR B;  2W5Y A;  3OXG A;  3KMA A;  5TTF A;  1O9S A;  3M56 A;  1MT6 A;  5EG2 A;  3CBM A;  3RAY A;  3S7B A;  3IHX A;  3S7D A;  5TEG A;  2RFI A;  4LDG A;  5F6L A;  5KJK A;  1N3J A;  3BO5 A;  2F69 A;  4YNM A;  3QWW A;  3VV0 A;  3SWC A;  2IGQ A;  4NVQ A;  4QEP A;  4YND A;  3CBO A;  3EP0 A;  4C1Q A;  5HQ8 A;  3HNA A;  2R3A A;  2JV0 A;  3M57 A;  3OPE A;  1N6A A;  1H3I A;  5T5G A;  3S8P A;  1ZKK A;  3KMJ A;  3F9Z A;  2G46 A;  3M58 A;  4WUY A; 
#chains in the Genus database with same CATH topology
 3QWV A;  2O8J A;  4QEO A;  4H12 A;  4JLG A;  3M54 A;  3F9Y A;  1XQH A;  3RIB A;  5CCM A;  4IJD A;  5KJL A;  3OXL A;  5JIY A;  4AU7 A;  4Z4P A;  1N6C A;  5T0K A;  3RU0 A;  3RJW A;  4YNP A;  4FMU A;  5HI7 A;  5KJM A;  3DB5 A;  4J7F A;  5JHN A;  3VUZ A;  5ARG A;  5JIN A;  5T0M A;  5EX3 A;  5TH7 A;  3FPD A;  3SW9 A;  4BUP A;  4YPU A;  4O6F A;  3RQ4 A;  5F6K C;  1MVX A;  4NJ5 A;  3QWP A;  3TG5 A;  3MEK A;  3MO5 A;  5F5E A;  2BQZ A;  5JJ0 A;  2QPW A;  1PEG A;  3OOI A;  5LSX A;  3F9W A;  5KJN A;  3OS5 A;  3MO0 A;  3N71 A;  1MUF A;  4J83 A;  4YPE A;  4O30 A;  4MI5 A;  5LSZ A;  3K5K A;  5ARF A;  3M59 A;  4J8O A;  4RZ0 A;  4E47 A;  1ML9 A;  2W5Z A;  3DAL A;  5CCL A;  5AYF A;  3KMT A;  5F59 A;  4IJ8 A;  4JDS A;  3S7F A;  3M53 A;  3OXF A;  3TG4 A;  3MO2 A;  3F9X A;  4QEN A;  5EX0 A;  3S7J A;  4I51 A;  3CBP A;  3M5A A;  1MVH A;  4YPA A;  3PDN A;  3M55 A;  4MI0 A;  4J7I A;  5CPR B;  2W5Y A;  3OXG A;  3KMA A;  5TTF A;  1O9S A;  3M56 A;  1MT6 A;  5EG2 A;  3CBM A;  3RAY A;  3S7B A;  3IHX A;  3S7D A;  5TEG A;  2RFI A;  4LDG A;  5F6L A;  5KJK A;  1N3J A;  3BO5 A;  2F69 A;  4YNM A;  3QWW A;  3VV0 A;  3SWC A;  2IGQ A;  4NVQ A;  4QEP A;  4YND A;  3CBO A;  3EP0 A;  4C1Q A;  5HQ8 A;  3HNA A;  2R3A A;  2JV0 A;  3M57 A;  3OPE A;  1N6A A;  1H3I A;  5T5G A;  3S8P A;  1ZKK A;  3KMJ A;  3F9Z A;  2G46 A;  3M58 A;  4WUY A; 
#chains in the Genus database with same CATH homology
 3QWV A;  2O8J A;  4QEO A;  4H12 A;  4JLG A;  3M54 A;  3F9Y A;  1XQH A;  3RIB A;  5CCM A;  4IJD A;  5KJL A;  3OXL A;  5JIY A;  4AU7 A;  4Z4P A;  1N6C A;  5T0K A;  3RU0 A;  3RJW A;  4YNP A;  4FMU A;  5HI7 A;  5KJM A;  3DB5 A;  4J7F A;  5JHN A;  3VUZ A;  5ARG A;  5JIN A;  5T0M A;  5EX3 A;  5TH7 A;  3FPD A;  3SW9 A;  4BUP A;  4YPU A;  4O6F A;  3RQ4 A;  5F6K C;  1MVX A;  4NJ5 A;  3QWP A;  3TG5 A;  3MEK A;  3MO5 A;  5F5E A;  2BQZ A;  5JJ0 A;  2QPW A;  1PEG A;  3OOI A;  5LSX A;  3F9W A;  5KJN A;  3OS5 A;  3MO0 A;  3N71 A;  1MUF A;  4J83 A;  4YPE A;  4O30 A;  4MI5 A;  5LSZ A;  3K5K A;  5ARF A;  3M59 A;  4J8O A;  4RZ0 A;  4E47 A;  1ML9 A;  2W5Z A;  3DAL A;  5CCL A;  5AYF A;  3KMT A;  5F59 A;  4IJ8 A;  4JDS A;  3S7F A;  3M53 A;  3OXF A;  3TG4 A;  3MO2 A;  3F9X A;  4QEN A;  5EX0 A;  3S7J A;  4I51 A;  3CBP A;  3M5A A;  1MVH A;  4YPA A;  3PDN A;  3M55 A;  4MI0 A;  4J7I A;  5CPR B;  2W5Y A;  3OXG A;  3KMA A;  5TTF A;  1O9S A;  3M56 A;  1MT6 A;  5EG2 A;  3CBM A;  3RAY A;  3S7B A;  3IHX A;  3S7D A;  5TEG A;  2RFI A;  4LDG A;  5F6L A;  5KJK A;  1N3J A;  3BO5 A;  2F69 A;  4YNM A;  3QWW A;  3VV0 A;  3SWC A;  2IGQ A;  4NVQ A;  4QEP A;  4YND A;  3CBO A;  3EP0 A;  4C1Q A;  5HQ8 A;  3HNA A;  2R3A A;  2JV0 A;  3M57 A;  3OPE A;  1N6A A;  1H3I A;  5T5G A;  3S8P A;  1ZKK A;  3KMJ A;  3F9Z A;  2G46 A;  3M58 A;  4WUY A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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