4I51A

Methyltransferase domain of human euchromatic histone methyltransferase 1, mutant y1211a
Total Genus 69
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
69
sequence length
261
structure length
261
Chain Sequence
VERIVSRDIARGYERIPIPCVNAVDSEPCPSNYKYVSQNCVTSPMNIDRNITHLQYCVCIDDCSSSNCMCGQLSMRCWYDKDGRLLPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLDNKDGEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDAGERFWDIKGKLFSCRCGSPKCRHS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Defining efficient enzyme-cofactor pairs for bioorthogonal profiling of protein methylation.
pubmed doi rcsb
molecule tags Transferase/peptide
source organism Homo sapiens
molecule keywords Histone-lysine N-methyltransferase EHMT1
total genus 69
structure length 261
sequence length 261
chains with identical sequence B
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2012-11-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF05033 Pre-SET Pre-SET motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 4i51A00
2RFIA 3QWWA 1N3JA 5F59A 4Z4PA 4YPAA 3N71A 3MEKA 5KJKA 4I51A 4QEPA 3FPDA 4JDSA 2QPWA 3M54A 5TEGA 4BUPA 4C1QA 3QWPA 3KMAA 5JHNA 5KJMA 3M5AA 3F9XA 3OPEA 3S7DA 2W5ZA 5T0MA 3QWVA 3DALA 3PDNA 1PEGA 5T0KA 3SWCA 3M56A 4FMUA 1ML9A 4J8OA 5F6LA 5JIYA 3VUZA 5LSZA 1MVXA 1O9SA 3KMTA 2O8JA 3CBMA 1MT6A 3F9ZA 3IHXA 3OXGA 4QEOA 5ARGA 3M53A 4MI5A 3BO5A 5TH7A 5LSXA 3M58A 4JLGA 5CCMA 4NJ5A 4IJDA 3RU0A 2R3AA 4YPEA 5ARFA 3F9WA 4J7FA 5EX0A 4AU7A 3S7FA 2W5YA 3SW9A 3M57A 5F5EA 3RJWA 5EX3A 5AYFA 3MO2A 3OXLA 3M59A 5T5GA 3KMJA 1N6CA 3M55A 3S7JA 5EG2A 1ZKKA 1N6AA 3CBOA 3S8PA 4IJ8A 5CPRB 5HI7A 2BQZA 3EP0A 4LDGA 1H3IA 2G46A 3DB5A 4H12A 2JV0A 2F69A 5CCLA 4NVQA 3TG4A 1MVHA 3MO0A 4YPUA 3HNAA 4YNMA 5KJLA 4E47A 1MUFA 4MI0A 3F9YA 3TG5A 5JJ0A 4O6FA 3MO5A 5F6KC 4J83A 3VV0A 3K5KA 4RZ0A 3OXFA 5TTFA 3RQ4A 4YNDA 3S7BA 4WUYA 3RIBA 2IGQA 5KJNA 3RAYA 5JINA 3OS5A 4QENA 1XQHA 3OOIA 3CBPA 5HQ8A 4YNPA 4O30A 4J7IA
chains in the Genus database with same CATH superfamily
2RFIA 3QWWA 1N3JA 5F59A 4Z4PA 4YPAA 3N71A 3MEKA 5KJKA 4I51A 4QEPA 3FPDA 4JDSA 2QPWA 3M54A 5TEGA 4BUPA 4C1QA 3QWPA 3KMAA 5JHNA 5KJMA 3M5AA 3F9XA 3OPEA 3S7DA 2W5ZA 5T0MA 3QWVA 3DALA 3PDNA 1PEGA 5T0KA 3SWCA 3M56A 4FMUA 1ML9A 4J8OA 5F6LA 5JIYA 3VUZA 5LSZA 1MVXA 1O9SA 3KMTA 2O8JA 3CBMA 1MT6A 3F9ZA 3IHXA 3OXGA 4QEOA 5ARGA 3M53A 4MI5A 3BO5A 5TH7A 5LSXA 3M58A 4JLGA 5CCMA 4NJ5A 4IJDA 3RU0A 2R3AA 4YPEA 5ARFA 3F9WA 4J7FA 5EX0A 4AU7A 3S7FA 2W5YA 3SW9A 3M57A 5F5EA 3RJWA 5EX3A 5AYFA 3MO2A 3OXLA 3M59A 5T5GA 3KMJA 1N6CA 3M55A 3S7JA 5EG2A 1ZKKA 1N6AA 3CBOA 3S8PA 4IJ8A 5CPRB 5HI7A 2BQZA 3EP0A 4LDGA 1H3IA 2G46A 3DB5A 4H12A 2JV0A 2F69A 5CCLA 4NVQA 3TG4A 1MVHA 3MO0A 4YPUA 3HNAA 4YNMA 5KJLA 4E47A 1MUFA 4MI0A 3F9YA 3TG5A 5JJ0A 4O6FA 3MO5A 5F6KC 4J83A 3VV0A 3K5KA 4RZ0A 3OXFA 5TTFA 3RQ4A 4YNDA 3S7BA 4WUYA 3RIBA 2IGQA 5KJNA 3RAYA 5JINA 3OS5A 4QENA 1XQHA 3OOIA 3CBPA 5HQ8A 4YNPA 4O30A 4J7IA
chains in the Genus database with same CATH topology
2RFIA 3QWWA 1N3JA 5F59A 4Z4PA 4YPAA 3N71A 3MEKA 5KJKA 4I51A 4QEPA 3FPDA 4JDSA 2QPWA 3M54A 5TEGA 4BUPA 4C1QA 3QWPA 3KMAA 5JHNA 5KJMA 3M5AA 3F9XA 3OPEA 3S7DA 2W5ZA 5T0MA 3QWVA 3DALA 3PDNA 1PEGA 5T0KA 3SWCA 3M56A 4FMUA 1ML9A 4J8OA 5F6LA 5JIYA 3VUZA 5LSZA 1MVXA 1O9SA 3KMTA 2O8JA 3CBMA 1MT6A 3F9ZA 3IHXA 3OXGA 4QEOA 5ARGA 3M53A 4MI5A 3BO5A 5TH7A 5LSXA 3M58A 4JLGA 5CCMA 4NJ5A 4IJDA 3RU0A 2R3AA 4YPEA 5ARFA 3F9WA 4J7FA 5EX0A 4AU7A 3S7FA 2W5YA 3SW9A 3M57A 5F5EA 3RJWA 5EX3A 5AYFA 3MO2A 3OXLA 3M59A 5T5GA 3KMJA 1N6CA 3M55A 3S7JA 5EG2A 1ZKKA 1N6AA 3CBOA 3S8PA 4IJ8A 5CPRB 5HI7A 2BQZA 3EP0A 4LDGA 1H3IA 2G46A 3DB5A 4H12A 2JV0A 2F69A 5CCLA 4NVQA 3TG4A 1MVHA 3MO0A 4YPUA 3HNAA 4YNMA 5KJLA 4E47A 1MUFA 4MI0A 3F9YA 3TG5A 5JJ0A 4O6FA 3MO5A 5F6KC 4J83A 3VV0A 3K5KA 4RZ0A 3OXFA 5TTFA 3RQ4A 4YNDA 3S7BA 4WUYA 3RIBA 2IGQA 5KJNA 3RAYA 5JINA 3OS5A 4QENA 1XQHA 3OOIA 3CBPA 5HQ8A 4YNPA 4O30A 4J7IA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2RFI A;  3QWW A;  1N3J A;  5F59 A;  4Z4P A;  4YPA A;  3N71 A;  3MEK A;  5KJK A;  4I51 A;  4QEP A;  3FPD A;  4JDS A;  2QPW A;  3M54 A;  5TEG A;  4BUP A;  4C1Q A;  3QWP A;  3KMA A;  5JHN A;  5KJM A;  3M5A A;  3F9X A;  3OPE A;  3S7D A;  2W5Z A;  5T0M A;  3QWV A;  3DAL A;  3PDN A;  1PEG A;  5T0K A;  3SWC A;  3M56 A;  4FMU A;  1ML9 A;  4J8O A;  5F6L A;  5JIY A;  3VUZ A;  5LSZ A;  1MVX A;  1O9S A;  3KMT A;  2O8J A;  3CBM A;  1MT6 A;  3F9Z A;  3IHX A;  3OXG A;  4QEO A;  5ARG A;  3M53 A;  4MI5 A;  3BO5 A;  5TH7 A;  5LSX A;  3M58 A;  4JLG A;  5CCM A;  4NJ5 A;  4IJD A;  3RU0 A;  2R3A A;  4YPE A;  5ARF A;  3F9W A;  4J7F A;  5EX0 A;  4AU7 A;  3S7F A;  2W5Y A;  3SW9 A;  3M57 A;  5F5E A;  3RJW A;  5EX3 A;  5AYF A;  3MO2 A;  3OXL A;  3M59 A;  5T5G A;  3KMJ A;  1N6C A;  3M55 A;  3S7J A;  5EG2 A;  1ZKK A;  1N6A A;  3CBO A;  3S8P A;  4IJ8 A;  5CPR B;  5HI7 A;  2BQZ A;  3EP0 A;  4LDG A;  1H3I A;  2G46 A;  3DB5 A;  4H12 A;  2JV0 A;  2F69 A;  5CCL A;  4NVQ A;  3TG4 A;  1MVH A;  3MO0 A;  4YPU A;  3HNA A;  4YNM A;  5KJL A;  4E47 A;  1MUF A;  4MI0 A;  3F9Y A;  3TG5 A;  5JJ0 A;  4O6F A;  3MO5 A;  5F6K C;  4J83 A;  3VV0 A;  3K5K A;  4RZ0 A;  3OXF A;  5TTF A;  3RQ4 A;  4YND A;  3S7B A;  4WUY A;  3RIB A;  2IGQ A;  5KJN A;  3RAY A;  5JIN A;  3OS5 A;  4QEN A;  1XQH A;  3OOI A;  3CBP A;  5HQ8 A;  4YNP A;  4O30 A;  4J7I A; 
#chains in the Genus database with same CATH topology
 2RFI A;  3QWW A;  1N3J A;  5F59 A;  4Z4P A;  4YPA A;  3N71 A;  3MEK A;  5KJK A;  4I51 A;  4QEP A;  3FPD A;  4JDS A;  2QPW A;  3M54 A;  5TEG A;  4BUP A;  4C1Q A;  3QWP A;  3KMA A;  5JHN A;  5KJM A;  3M5A A;  3F9X A;  3OPE A;  3S7D A;  2W5Z A;  5T0M A;  3QWV A;  3DAL A;  3PDN A;  1PEG A;  5T0K A;  3SWC A;  3M56 A;  4FMU A;  1ML9 A;  4J8O A;  5F6L A;  5JIY A;  3VUZ A;  5LSZ A;  1MVX A;  1O9S A;  3KMT A;  2O8J A;  3CBM A;  1MT6 A;  3F9Z A;  3IHX A;  3OXG A;  4QEO A;  5ARG A;  3M53 A;  4MI5 A;  3BO5 A;  5TH7 A;  5LSX A;  3M58 A;  4JLG A;  5CCM A;  4NJ5 A;  4IJD A;  3RU0 A;  2R3A A;  4YPE A;  5ARF A;  3F9W A;  4J7F A;  5EX0 A;  4AU7 A;  3S7F A;  2W5Y A;  3SW9 A;  3M57 A;  5F5E A;  3RJW A;  5EX3 A;  5AYF A;  3MO2 A;  3OXL A;  3M59 A;  5T5G A;  3KMJ A;  1N6C A;  3M55 A;  3S7J A;  5EG2 A;  1ZKK A;  1N6A A;  3CBO A;  3S8P A;  4IJ8 A;  5CPR B;  5HI7 A;  2BQZ A;  3EP0 A;  4LDG A;  1H3I A;  2G46 A;  3DB5 A;  4H12 A;  2JV0 A;  2F69 A;  5CCL A;  4NVQ A;  3TG4 A;  1MVH A;  3MO0 A;  4YPU A;  3HNA A;  4YNM A;  5KJL A;  4E47 A;  1MUF A;  4MI0 A;  3F9Y A;  3TG5 A;  5JJ0 A;  4O6F A;  3MO5 A;  5F6K C;  4J83 A;  3VV0 A;  3K5K A;  4RZ0 A;  3OXF A;  5TTF A;  3RQ4 A;  4YND A;  3S7B A;  4WUY A;  3RIB A;  2IGQ A;  5KJN A;  3RAY A;  5JIN A;  3OS5 A;  4QEN A;  1XQH A;  3OOI A;  3CBP A;  5HQ8 A;  4YNP A;  4O30 A;  4J7I A; 
#chains in the Genus database with same CATH homology
 2RFI A;  3QWW A;  1N3J A;  5F59 A;  4Z4P A;  4YPA A;  3N71 A;  3MEK A;  5KJK A;  4I51 A;  4QEP A;  3FPD A;  4JDS A;  2QPW A;  3M54 A;  5TEG A;  4BUP A;  4C1Q A;  3QWP A;  3KMA A;  5JHN A;  5KJM A;  3M5A A;  3F9X A;  3OPE A;  3S7D A;  2W5Z A;  5T0M A;  3QWV A;  3DAL A;  3PDN A;  1PEG A;  5T0K A;  3SWC A;  3M56 A;  4FMU A;  1ML9 A;  4J8O A;  5F6L A;  5JIY A;  3VUZ A;  5LSZ A;  1MVX A;  1O9S A;  3KMT A;  2O8J A;  3CBM A;  1MT6 A;  3F9Z A;  3IHX A;  3OXG A;  4QEO A;  5ARG A;  3M53 A;  4MI5 A;  3BO5 A;  5TH7 A;  5LSX A;  3M58 A;  4JLG A;  5CCM A;  4NJ5 A;  4IJD A;  3RU0 A;  2R3A A;  4YPE A;  5ARF A;  3F9W A;  4J7F A;  5EX0 A;  4AU7 A;  3S7F A;  2W5Y A;  3SW9 A;  3M57 A;  5F5E A;  3RJW A;  5EX3 A;  5AYF A;  3MO2 A;  3OXL A;  3M59 A;  5T5G A;  3KMJ A;  1N6C A;  3M55 A;  3S7J A;  5EG2 A;  1ZKK A;  1N6A A;  3CBO A;  3S8P A;  4IJ8 A;  5CPR B;  5HI7 A;  2BQZ A;  3EP0 A;  4LDG A;  1H3I A;  2G46 A;  3DB5 A;  4H12 A;  2JV0 A;  2F69 A;  5CCL A;  4NVQ A;  3TG4 A;  1MVH A;  3MO0 A;  4YPU A;  3HNA A;  4YNM A;  5KJL A;  4E47 A;  1MUF A;  4MI0 A;  3F9Y A;  3TG5 A;  5JJ0 A;  4O6F A;  3MO5 A;  5F6K C;  4J83 A;  3VV0 A;  3K5K A;  4RZ0 A;  3OXF A;  5TTF A;  3RQ4 A;  4YND A;  3S7B A;  4WUY A;  3RIB A;  2IGQ A;  5KJN A;  3RAY A;  5JIN A;  3OS5 A;  4QEN A;  1XQH A;  3OOI A;  3CBP A;  5HQ8 A;  4YNP A;  4O30 A;  4J7I A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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