4I51A

Methyltransferase domain of human euchromatic histone methyltransferase 1, mutant y1211a
Total Genus 69
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
69
sequence length
261
structure length
261
Chain Sequence
VERIVSRDIARGYERIPIPCVNAVDSEPCPSNYKYVSQNCVTSPMNIDRNITHLQYCVCIDDCSSSNCMCGQLSMRCWYDKDGRLLPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLDNKDGEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDAGERFWDIKGKLFSCRCGSPKCRHS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Defining efficient enzyme-cofactor pairs for bioorthogonal profiling of protein methylation.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Transferase/peptide
molecule keywords Histone-lysine N-methyltransferase EHMT1
total genus 69
structure length 261
sequence length 261
chains with identical sequence B
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2012-11-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF05033 Pre-SET Pre-SET motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 4i51A00
2BQZA 5JHNA 5HI7A 4I51A 5F59A 3KMTA 3N71A 4YPEA 3OPEA 5EX0A 4JLGA 3M57A 4NJ5A 4FMUA 4YNPA 4YPAA 3HNAA 3OXFA 3QWPA 5F6KC 1O9SA 3M59A 3VUZA 3OXLA 3RAYA 1MVXA 4IJ8A 4WUYA 3MO0A 3MEKA 4J7FA 5ARFA 3BO5A 5CPRB 4C1QA 5AYFA 4J8OA 1ZKKA 5CCMA 4BUPA 3RJWA 3OXGA 3M53A 5LSZA 4Z4PA 4H12A 5JJ0A 4AU7A 5JINA 5KJKA 3DB5A 4QEOA 3SW9A 5F6LA 3CBOA 5EG2A 4LDGA 3VV0A 3F9WA 3PDNA 3TG5A 2O8JA 2QPWA 4MI0A 2JV0A 1N3JA 5JIYA 5KJLA 2F69A 4NVQA 3M5AA 1ML9A 4QEPA 3M55A 3F9ZA 1MUFA 3QWVA 1XQHA 3CBPA 4IJDA 4RZ0A 3S7BA 2IGQA 2W5ZA 3CBMA 4MI5A 5F5EA 5T0MA 4O30A 5T5GA 1N6AA 3KMAA 3IHXA 4JDSA 4YPUA 5EX3A 3RU0A 5ARGA 3F9YA 2W5YA 3RIBA 4YNMA 1MT6A 5HQ8A 3FPDA 1MVHA 3M58A 4E47A 3M54A 3EP0A 3QWWA 4O6FA 3S7FA 5T0KA 5KJMA 2RFIA 4QENA 3OOIA 5CCLA 3MO2A 3KMJA 5TEGA 3S8PA 3K5KA 3OS5A 3S7DA 5LSXA 3F9XA 3M56A 3MO5A 2R3AA 3RQ4A 5TH7A 1H3IA 5KJNA 4YNDA 1PEGA 4J7IA 3TG4A 3SWCA 3S7JA 3DALA 4J83A 1N6CA 5TTFA 2G46A
chains in the Genus database with same CATH superfamily
2BQZA 5JHNA 5HI7A 4I51A 5F59A 3KMTA 3N71A 4YPEA 3OPEA 5EX0A 4JLGA 3M57A 4NJ5A 4FMUA 4YNPA 4YPAA 3HNAA 3OXFA 3QWPA 5F6KC 1O9SA 3M59A 3VUZA 3OXLA 3RAYA 1MVXA 4IJ8A 4WUYA 3MO0A 3MEKA 4J7FA 5ARFA 3BO5A 5CPRB 4C1QA 5AYFA 4J8OA 1ZKKA 5CCMA 4BUPA 3RJWA 3OXGA 3M53A 5LSZA 4Z4PA 4H12A 5JJ0A 4AU7A 5JINA 5KJKA 3DB5A 4QEOA 3SW9A 5F6LA 3CBOA 5EG2A 4LDGA 3VV0A 3F9WA 3PDNA 3TG5A 2O8JA 2QPWA 4MI0A 2JV0A 1N3JA 5JIYA 5KJLA 2F69A 4NVQA 3M5AA 1ML9A 4QEPA 3M55A 3F9ZA 1MUFA 3QWVA 1XQHA 3CBPA 4IJDA 4RZ0A 3S7BA 2IGQA 2W5ZA 3CBMA 4MI5A 5F5EA 5T0MA 4O30A 5T5GA 1N6AA 3KMAA 3IHXA 4JDSA 4YPUA 5EX3A 3RU0A 5ARGA 3F9YA 2W5YA 3RIBA 4YNMA 1MT6A 5HQ8A 3FPDA 1MVHA 3M58A 4E47A 3M54A 3EP0A 3QWWA 4O6FA 3S7FA 5T0KA 5KJMA 2RFIA 4QENA 3OOIA 5CCLA 3MO2A 3KMJA 5TEGA 3S8PA 3K5KA 3OS5A 3S7DA 5LSXA 3F9XA 3M56A 3MO5A 2R3AA 3RQ4A 5TH7A 1H3IA 5KJNA 4YNDA 1PEGA 4J7IA 3TG4A 3SWCA 3S7JA 3DALA 4J83A 1N6CA 5TTFA 2G46A
chains in the Genus database with same CATH topology
2BQZA 5JHNA 5HI7A 4I51A 5F59A 3KMTA 3N71A 4YPEA 3OPEA 5EX0A 4JLGA 3M57A 4NJ5A 4FMUA 4YNPA 4YPAA 3HNAA 3OXFA 3QWPA 5F6KC 1O9SA 3M59A 3VUZA 3OXLA 3RAYA 1MVXA 4IJ8A 4WUYA 3MO0A 3MEKA 4J7FA 5ARFA 3BO5A 5CPRB 4C1QA 5AYFA 4J8OA 1ZKKA 5CCMA 4BUPA 3RJWA 3OXGA 3M53A 5LSZA 4Z4PA 4H12A 5JJ0A 4AU7A 5JINA 5KJKA 3DB5A 4QEOA 3SW9A 5F6LA 3CBOA 5EG2A 4LDGA 3VV0A 3F9WA 3PDNA 3TG5A 2O8JA 2QPWA 4MI0A 2JV0A 1N3JA 5JIYA 5KJLA 2F69A 4NVQA 3M5AA 1ML9A 4QEPA 3M55A 3F9ZA 1MUFA 3QWVA 1XQHA 3CBPA 4IJDA 4RZ0A 3S7BA 2IGQA 2W5ZA 3CBMA 4MI5A 5F5EA 5T0MA 4O30A 5T5GA 1N6AA 3KMAA 3IHXA 4JDSA 4YPUA 5EX3A 3RU0A 5ARGA 3F9YA 2W5YA 3RIBA 4YNMA 1MT6A 5HQ8A 3FPDA 1MVHA 3M58A 4E47A 3M54A 3EP0A 3QWWA 4O6FA 3S7FA 5T0KA 5KJMA 2RFIA 4QENA 3OOIA 5CCLA 3MO2A 3KMJA 5TEGA 3S8PA 3K5KA 3OS5A 3S7DA 5LSXA 3F9XA 3M56A 3MO5A 2R3AA 3RQ4A 5TH7A 1H3IA 5KJNA 4YNDA 1PEGA 4J7IA 3TG4A 3SWCA 3S7JA 3DALA 4J83A 1N6CA 5TTFA 2G46A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2BQZ A;  5JHN A;  5HI7 A;  4I51 A;  5F59 A;  3KMT A;  3N71 A;  4YPE A;  3OPE A;  5EX0 A;  4JLG A;  3M57 A;  4NJ5 A;  4FMU A;  4YNP A;  4YPA A;  3HNA A;  3OXF A;  3QWP A;  5F6K C;  1O9S A;  3M59 A;  3VUZ A;  3OXL A;  3RAY A;  1MVX A;  4IJ8 A;  4WUY A;  3MO0 A;  3MEK A;  4J7F A;  5ARF A;  3BO5 A;  5CPR B;  4C1Q A;  5AYF A;  4J8O A;  1ZKK A;  5CCM A;  4BUP A;  3RJW A;  3OXG A;  3M53 A;  5LSZ A;  4Z4P A;  4H12 A;  5JJ0 A;  4AU7 A;  5JIN A;  5KJK A;  3DB5 A;  4QEO A;  3SW9 A;  5F6L A;  3CBO A;  5EG2 A;  4LDG A;  3VV0 A;  3F9W A;  3PDN A;  3TG5 A;  2O8J A;  2QPW A;  4MI0 A;  2JV0 A;  1N3J A;  5JIY A;  5KJL A;  2F69 A;  4NVQ A;  3M5A A;  1ML9 A;  4QEP A;  3M55 A;  3F9Z A;  1MUF A;  3QWV A;  1XQH A;  3CBP A;  4IJD A;  4RZ0 A;  3S7B A;  2IGQ A;  2W5Z A;  3CBM A;  4MI5 A;  5F5E A;  5T0M A;  4O30 A;  5T5G A;  1N6A A;  3KMA A;  3IHX A;  4JDS A;  4YPU A;  5EX3 A;  3RU0 A;  5ARG A;  3F9Y A;  2W5Y A;  3RIB A;  4YNM A;  1MT6 A;  5HQ8 A;  3FPD A;  1MVH A;  3M58 A;  4E47 A;  3M54 A;  3EP0 A;  3QWW A;  4O6F A;  3S7F A;  5T0K A;  5KJM A;  2RFI A;  4QEN A;  3OOI A;  5CCL A;  3MO2 A;  3KMJ A;  5TEG A;  3S8P A;  3K5K A;  3OS5 A;  3S7D A;  5LSX A;  3F9X A;  3M56 A;  3MO5 A;  2R3A A;  3RQ4 A;  5TH7 A;  1H3I A;  5KJN A;  4YND A;  1PEG A;  4J7I A;  3TG4 A;  3SWC A;  3S7J A;  3DAL A;  4J83 A;  1N6C A;  5TTF A;  2G46 A; 
#chains in the Genus database with same CATH topology
 2BQZ A;  5JHN A;  5HI7 A;  4I51 A;  5F59 A;  3KMT A;  3N71 A;  4YPE A;  3OPE A;  5EX0 A;  4JLG A;  3M57 A;  4NJ5 A;  4FMU A;  4YNP A;  4YPA A;  3HNA A;  3OXF A;  3QWP A;  5F6K C;  1O9S A;  3M59 A;  3VUZ A;  3OXL A;  3RAY A;  1MVX A;  4IJ8 A;  4WUY A;  3MO0 A;  3MEK A;  4J7F A;  5ARF A;  3BO5 A;  5CPR B;  4C1Q A;  5AYF A;  4J8O A;  1ZKK A;  5CCM A;  4BUP A;  3RJW A;  3OXG A;  3M53 A;  5LSZ A;  4Z4P A;  4H12 A;  5JJ0 A;  4AU7 A;  5JIN A;  5KJK A;  3DB5 A;  4QEO A;  3SW9 A;  5F6L A;  3CBO A;  5EG2 A;  4LDG A;  3VV0 A;  3F9W A;  3PDN A;  3TG5 A;  2O8J A;  2QPW A;  4MI0 A;  2JV0 A;  1N3J A;  5JIY A;  5KJL A;  2F69 A;  4NVQ A;  3M5A A;  1ML9 A;  4QEP A;  3M55 A;  3F9Z A;  1MUF A;  3QWV A;  1XQH A;  3CBP A;  4IJD A;  4RZ0 A;  3S7B A;  2IGQ A;  2W5Z A;  3CBM A;  4MI5 A;  5F5E A;  5T0M A;  4O30 A;  5T5G A;  1N6A A;  3KMA A;  3IHX A;  4JDS A;  4YPU A;  5EX3 A;  3RU0 A;  5ARG A;  3F9Y A;  2W5Y A;  3RIB A;  4YNM A;  1MT6 A;  5HQ8 A;  3FPD A;  1MVH A;  3M58 A;  4E47 A;  3M54 A;  3EP0 A;  3QWW A;  4O6F A;  3S7F A;  5T0K A;  5KJM A;  2RFI A;  4QEN A;  3OOI A;  5CCL A;  3MO2 A;  3KMJ A;  5TEG A;  3S8P A;  3K5K A;  3OS5 A;  3S7D A;  5LSX A;  3F9X A;  3M56 A;  3MO5 A;  2R3A A;  3RQ4 A;  5TH7 A;  1H3I A;  5KJN A;  4YND A;  1PEG A;  4J7I A;  3TG4 A;  3SWC A;  3S7J A;  3DAL A;  4J83 A;  1N6C A;  5TTF A;  2G46 A; 
#chains in the Genus database with same CATH homology
 2BQZ A;  5JHN A;  5HI7 A;  4I51 A;  5F59 A;  3KMT A;  3N71 A;  4YPE A;  3OPE A;  5EX0 A;  4JLG A;  3M57 A;  4NJ5 A;  4FMU A;  4YNP A;  4YPA A;  3HNA A;  3OXF A;  3QWP A;  5F6K C;  1O9S A;  3M59 A;  3VUZ A;  3OXL A;  3RAY A;  1MVX A;  4IJ8 A;  4WUY A;  3MO0 A;  3MEK A;  4J7F A;  5ARF A;  3BO5 A;  5CPR B;  4C1Q A;  5AYF A;  4J8O A;  1ZKK A;  5CCM A;  4BUP A;  3RJW A;  3OXG A;  3M53 A;  5LSZ A;  4Z4P A;  4H12 A;  5JJ0 A;  4AU7 A;  5JIN A;  5KJK A;  3DB5 A;  4QEO A;  3SW9 A;  5F6L A;  3CBO A;  5EG2 A;  4LDG A;  3VV0 A;  3F9W A;  3PDN A;  3TG5 A;  2O8J A;  2QPW A;  4MI0 A;  2JV0 A;  1N3J A;  5JIY A;  5KJL A;  2F69 A;  4NVQ A;  3M5A A;  1ML9 A;  4QEP A;  3M55 A;  3F9Z A;  1MUF A;  3QWV A;  1XQH A;  3CBP A;  4IJD A;  4RZ0 A;  3S7B A;  2IGQ A;  2W5Z A;  3CBM A;  4MI5 A;  5F5E A;  5T0M A;  4O30 A;  5T5G A;  1N6A A;  3KMA A;  3IHX A;  4JDS A;  4YPU A;  5EX3 A;  3RU0 A;  5ARG A;  3F9Y A;  2W5Y A;  3RIB A;  4YNM A;  1MT6 A;  5HQ8 A;  3FPD A;  1MVH A;  3M58 A;  4E47 A;  3M54 A;  3EP0 A;  3QWW A;  4O6F A;  3S7F A;  5T0K A;  5KJM A;  2RFI A;  4QEN A;  3OOI A;  5CCL A;  3MO2 A;  3KMJ A;  5TEG A;  3S8P A;  3K5K A;  3OS5 A;  3S7D A;  5LSX A;  3F9X A;  3M56 A;  3MO5 A;  2R3A A;  3RQ4 A;  5TH7 A;  1H3I A;  5KJN A;  4YND A;  1PEG A;  4J7I A;  3TG4 A;  3SWC A;  3S7J A;  3DAL A;  4J83 A;  1N6C A;  5TTF A;  2G46 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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