4I51A

Methyltransferase domain of human euchromatic histone methyltransferase 1, mutant y1211a
Total Genus 69
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
69
sequence length
261
structure length
261
Chain Sequence
VERIVSRDIARGYERIPIPCVNAVDSEPCPSNYKYVSQNCVTSPMNIDRNITHLQYCVCIDDCSSSNCMCGQLSMRCWYDKDGRLLPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLDNKDGEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDAGERFWDIKGKLFSCRCGSPKCRHS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Transferase/peptide
molecule keywords Histone-lysine N-methyltransferase EHMT1
publication title Defining efficient enzyme-cofactor pairs for bioorthogonal profiling of protein methylation.
pubmed doi rcsb
source organism Homo sapiens
total genus 69
structure length 261
sequence length 261
chains with identical sequence B
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2012-11-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF05033 Pre-SET Pre-SET motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 4i51A00
2R3AA 4J83A 3QWWA 4AU7A 3VUZA 1ML9A 5F59A 3MO2A 3M59A 3K5KA 5JIYA 3OXLA 5AYFA 5TEGA 5KJLA 5KJKA 5T0KA 5CPRB 2O8JA 3S8PA 5JINA 5CCLA 5HQ8A 1PEGA 2F69A 4FMUA 4J8OA 4WUYA 1MUFA 4QEOA 5F5EA 4O6FA 4J7FA 3M56A 3RIBA 5TTFA 3EP0A 5HI7A 3MO5A 5T5GA 4JDSA 4Z4PA 4I51A 5ARGA 3F9XA 3F9WA 5JJ0A 3DB5A 5EX0A 3KMJA 3PDNA 3SW9A 5LSXA 4H12A 4IJ8A 3S7JA 5TH7A 2W5YA 5CCMA 3CBOA 4MI0A 4MI5A 4RZ0A 3M54A 3HNAA 5T0MA 1N6CA 1N3JA 3M58A 2QPWA 2JV0A 2IGQA 3S7FA 4C1QA 5EG2A 3MEKA 5LSZA 5KJMA 5EX3A 4QENA 3OXGA 3IHXA 3FPDA 3M57A 1MVXA 3S7DA 3KMTA 3RQ4A 3MO0A 4YPUA 2BQZA 3S7BA 2RFIA 3M5AA 4IJDA 3OS5A 3M53A 4J7IA 4NVQA 2W5ZA 3VV0A 3TG4A 3M55A 3OPEA 2G46A 1MT6A 1ZKKA 5KJNA 3F9YA 1MVHA 1O9SA 4YNDA 4YPEA 1H3IA 4YPAA 3OOIA 4YNPA 3RJWA 4YNMA 3CBPA 3TG5A 4BUPA 3QWVA 1XQHA 4LDGA 3DALA 4QEPA 3N71A 3CBMA 3F9ZA 5JHNA 5F6KC 4NJ5A 4O30A 5ARFA 3QWPA 3OXFA 3BO5A 4JLGA 4E47A 3RAYA 1N6AA 5F6LA 3RU0A 3SWCA 3KMAA
chains in the Genus database with same CATH superfamily
2R3AA 4J83A 3QWWA 4AU7A 3VUZA 1ML9A 5F59A 3MO2A 3M59A 3K5KA 5JIYA 3OXLA 5AYFA 5TEGA 5KJLA 5KJKA 5T0KA 5CPRB 2O8JA 3S8PA 5JINA 5CCLA 5HQ8A 1PEGA 2F69A 4FMUA 4J8OA 4WUYA 1MUFA 4QEOA 5F5EA 4O6FA 4J7FA 3M56A 3RIBA 5TTFA 3EP0A 5HI7A 3MO5A 5T5GA 4JDSA 4Z4PA 4I51A 5ARGA 3F9XA 3F9WA 5JJ0A 3DB5A 5EX0A 3KMJA 3PDNA 3SW9A 5LSXA 4H12A 4IJ8A 3S7JA 5TH7A 2W5YA 5CCMA 3CBOA 4MI0A 4MI5A 4RZ0A 3M54A 3HNAA 5T0MA 1N6CA 1N3JA 3M58A 2QPWA 2JV0A 2IGQA 3S7FA 4C1QA 5EG2A 3MEKA 5LSZA 5KJMA 5EX3A 4QENA 3OXGA 3IHXA 3FPDA 3M57A 1MVXA 3S7DA 3KMTA 3RQ4A 3MO0A 4YPUA 2BQZA 3S7BA 2RFIA 3M5AA 4IJDA 3OS5A 3M53A 4J7IA 4NVQA 2W5ZA 3VV0A 3TG4A 3M55A 3OPEA 2G46A 1MT6A 1ZKKA 5KJNA 3F9YA 1MVHA 1O9SA 4YNDA 4YPEA 1H3IA 4YPAA 3OOIA 4YNPA 3RJWA 4YNMA 3CBPA 3TG5A 4BUPA 3QWVA 1XQHA 4LDGA 3DALA 4QEPA 3N71A 3CBMA 3F9ZA 5JHNA 5F6KC 4NJ5A 4O30A 5ARFA 3QWPA 3OXFA 3BO5A 4JLGA 4E47A 3RAYA 1N6AA 5F6LA 3RU0A 3SWCA 3KMAA
chains in the Genus database with same CATH topology
2R3AA 4J83A 3QWWA 4AU7A 3VUZA 1ML9A 5F59A 3MO2A 3M59A 3K5KA 5JIYA 3OXLA 5AYFA 5TEGA 5KJLA 5KJKA 5T0KA 5CPRB 2O8JA 3S8PA 5JINA 5CCLA 5HQ8A 1PEGA 2F69A 4FMUA 4J8OA 4WUYA 1MUFA 4QEOA 5F5EA 4O6FA 4J7FA 3M56A 3RIBA 5TTFA 3EP0A 5HI7A 3MO5A 5T5GA 4JDSA 4Z4PA 4I51A 5ARGA 3F9XA 3F9WA 5JJ0A 3DB5A 5EX0A 3KMJA 3PDNA 3SW9A 5LSXA 4H12A 4IJ8A 3S7JA 5TH7A 2W5YA 5CCMA 3CBOA 4MI0A 4MI5A 4RZ0A 3M54A 3HNAA 5T0MA 1N6CA 1N3JA 3M58A 2QPWA 2JV0A 2IGQA 3S7FA 4C1QA 5EG2A 3MEKA 5LSZA 5KJMA 5EX3A 4QENA 3OXGA 3IHXA 3FPDA 3M57A 1MVXA 3S7DA 3KMTA 3RQ4A 3MO0A 4YPUA 2BQZA 3S7BA 2RFIA 3M5AA 4IJDA 3OS5A 3M53A 4J7IA 4NVQA 2W5ZA 3VV0A 3TG4A 3M55A 3OPEA 2G46A 1MT6A 1ZKKA 5KJNA 3F9YA 1MVHA 1O9SA 4YNDA 4YPEA 1H3IA 4YPAA 3OOIA 4YNPA 3RJWA 4YNMA 3CBPA 3TG5A 4BUPA 3QWVA 1XQHA 4LDGA 3DALA 4QEPA 3N71A 3CBMA 3F9ZA 5JHNA 5F6KC 4NJ5A 4O30A 5ARFA 3QWPA 3OXFA 3BO5A 4JLGA 4E47A 3RAYA 1N6AA 5F6LA 3RU0A 3SWCA 3KMAA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2R3A A;  4J83 A;  3QWW A;  4AU7 A;  3VUZ A;  1ML9 A;  5F59 A;  3MO2 A;  3M59 A;  3K5K A;  5JIY A;  3OXL A;  5AYF A;  5TEG A;  5KJL A;  5KJK A;  5T0K A;  5CPR B;  2O8J A;  3S8P A;  5JIN A;  5CCL A;  5HQ8 A;  1PEG A;  2F69 A;  4FMU A;  4J8O A;  4WUY A;  1MUF A;  4QEO A;  5F5E A;  4O6F A;  4J7F A;  3M56 A;  3RIB A;  5TTF A;  3EP0 A;  5HI7 A;  3MO5 A;  5T5G A;  4JDS A;  4Z4P A;  4I51 A;  5ARG A;  3F9X A;  3F9W A;  5JJ0 A;  3DB5 A;  5EX0 A;  3KMJ A;  3PDN A;  3SW9 A;  5LSX A;  4H12 A;  4IJ8 A;  3S7J A;  5TH7 A;  2W5Y A;  5CCM A;  3CBO A;  4MI0 A;  4MI5 A;  4RZ0 A;  3M54 A;  3HNA A;  5T0M A;  1N6C A;  1N3J A;  3M58 A;  2QPW A;  2JV0 A;  2IGQ A;  3S7F A;  4C1Q A;  5EG2 A;  3MEK A;  5LSZ A;  5KJM A;  5EX3 A;  4QEN A;  3OXG A;  3IHX A;  3FPD A;  3M57 A;  1MVX A;  3S7D A;  3KMT A;  3RQ4 A;  3MO0 A;  4YPU A;  2BQZ A;  3S7B A;  2RFI A;  3M5A A;  4IJD A;  3OS5 A;  3M53 A;  4J7I A;  4NVQ A;  2W5Z A;  3VV0 A;  3TG4 A;  3M55 A;  3OPE A;  2G46 A;  1MT6 A;  1ZKK A;  5KJN A;  3F9Y A;  1MVH A;  1O9S A;  4YND A;  4YPE A;  1H3I A;  4YPA A;  3OOI A;  4YNP A;  3RJW A;  4YNM A;  3CBP A;  3TG5 A;  4BUP A;  3QWV A;  1XQH A;  4LDG A;  3DAL A;  4QEP A;  3N71 A;  3CBM A;  3F9Z A;  5JHN A;  5F6K C;  4NJ5 A;  4O30 A;  5ARF A;  3QWP A;  3OXF A;  3BO5 A;  4JLG A;  4E47 A;  3RAY A;  1N6A A;  5F6L A;  3RU0 A;  3SWC A;  3KMA A; 
#chains in the Genus database with same CATH topology
 2R3A A;  4J83 A;  3QWW A;  4AU7 A;  3VUZ A;  1ML9 A;  5F59 A;  3MO2 A;  3M59 A;  3K5K A;  5JIY A;  3OXL A;  5AYF A;  5TEG A;  5KJL A;  5KJK A;  5T0K A;  5CPR B;  2O8J A;  3S8P A;  5JIN A;  5CCL A;  5HQ8 A;  1PEG A;  2F69 A;  4FMU A;  4J8O A;  4WUY A;  1MUF A;  4QEO A;  5F5E A;  4O6F A;  4J7F A;  3M56 A;  3RIB A;  5TTF A;  3EP0 A;  5HI7 A;  3MO5 A;  5T5G A;  4JDS A;  4Z4P A;  4I51 A;  5ARG A;  3F9X A;  3F9W A;  5JJ0 A;  3DB5 A;  5EX0 A;  3KMJ A;  3PDN A;  3SW9 A;  5LSX A;  4H12 A;  4IJ8 A;  3S7J A;  5TH7 A;  2W5Y A;  5CCM A;  3CBO A;  4MI0 A;  4MI5 A;  4RZ0 A;  3M54 A;  3HNA A;  5T0M A;  1N6C A;  1N3J A;  3M58 A;  2QPW A;  2JV0 A;  2IGQ A;  3S7F A;  4C1Q A;  5EG2 A;  3MEK A;  5LSZ A;  5KJM A;  5EX3 A;  4QEN A;  3OXG A;  3IHX A;  3FPD A;  3M57 A;  1MVX A;  3S7D A;  3KMT A;  3RQ4 A;  3MO0 A;  4YPU A;  2BQZ A;  3S7B A;  2RFI A;  3M5A A;  4IJD A;  3OS5 A;  3M53 A;  4J7I A;  4NVQ A;  2W5Z A;  3VV0 A;  3TG4 A;  3M55 A;  3OPE A;  2G46 A;  1MT6 A;  1ZKK A;  5KJN A;  3F9Y A;  1MVH A;  1O9S A;  4YND A;  4YPE A;  1H3I A;  4YPA A;  3OOI A;  4YNP A;  3RJW A;  4YNM A;  3CBP A;  3TG5 A;  4BUP A;  3QWV A;  1XQH A;  4LDG A;  3DAL A;  4QEP A;  3N71 A;  3CBM A;  3F9Z A;  5JHN A;  5F6K C;  4NJ5 A;  4O30 A;  5ARF A;  3QWP A;  3OXF A;  3BO5 A;  4JLG A;  4E47 A;  3RAY A;  1N6A A;  5F6L A;  3RU0 A;  3SWC A;  3KMA A; 
#chains in the Genus database with same CATH homology
 2R3A A;  4J83 A;  3QWW A;  4AU7 A;  3VUZ A;  1ML9 A;  5F59 A;  3MO2 A;  3M59 A;  3K5K A;  5JIY A;  3OXL A;  5AYF A;  5TEG A;  5KJL A;  5KJK A;  5T0K A;  5CPR B;  2O8J A;  3S8P A;  5JIN A;  5CCL A;  5HQ8 A;  1PEG A;  2F69 A;  4FMU A;  4J8O A;  4WUY A;  1MUF A;  4QEO A;  5F5E A;  4O6F A;  4J7F A;  3M56 A;  3RIB A;  5TTF A;  3EP0 A;  5HI7 A;  3MO5 A;  5T5G A;  4JDS A;  4Z4P A;  4I51 A;  5ARG A;  3F9X A;  3F9W A;  5JJ0 A;  3DB5 A;  5EX0 A;  3KMJ A;  3PDN A;  3SW9 A;  5LSX A;  4H12 A;  4IJ8 A;  3S7J A;  5TH7 A;  2W5Y A;  5CCM A;  3CBO A;  4MI0 A;  4MI5 A;  4RZ0 A;  3M54 A;  3HNA A;  5T0M A;  1N6C A;  1N3J A;  3M58 A;  2QPW A;  2JV0 A;  2IGQ A;  3S7F A;  4C1Q A;  5EG2 A;  3MEK A;  5LSZ A;  5KJM A;  5EX3 A;  4QEN A;  3OXG A;  3IHX A;  3FPD A;  3M57 A;  1MVX A;  3S7D A;  3KMT A;  3RQ4 A;  3MO0 A;  4YPU A;  2BQZ A;  3S7B A;  2RFI A;  3M5A A;  4IJD A;  3OS5 A;  3M53 A;  4J7I A;  4NVQ A;  2W5Z A;  3VV0 A;  3TG4 A;  3M55 A;  3OPE A;  2G46 A;  1MT6 A;  1ZKK A;  5KJN A;  3F9Y A;  1MVH A;  1O9S A;  4YND A;  4YPE A;  1H3I A;  4YPA A;  3OOI A;  4YNP A;  3RJW A;  4YNM A;  3CBP A;  3TG5 A;  4BUP A;  3QWV A;  1XQH A;  4LDG A;  3DAL A;  4QEP A;  3N71 A;  3CBM A;  3F9Z A;  5JHN A;  5F6K C;  4NJ5 A;  4O30 A;  5ARF A;  3QWP A;  3OXF A;  3BO5 A;  4JLG A;  4E47 A;  3RAY A;  1N6A A;  5F6L A;  3RU0 A;  3SWC A;  3KMA A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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