4I51A

Methyltransferase domain of human euchromatic histone methyltransferase 1, mutant y1211a
Total Genus 69
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
69
sequence length
261
structure length
261
Chain Sequence
VERIVSRDIARGYERIPIPCVNAVDSEPCPSNYKYVSQNCVTSPMNIDRNITHLQYCVCIDDCSSSNCMCGQLSMRCWYDKDGRLLPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLDNKDGEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDAGERFWDIKGKLFSCRCGSPKCRHS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Histone-lysine N-methyltransferase EHMT1
publication title Defining efficient enzyme-cofactor pairs for bioorthogonal profiling of protein methylation.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Transferase/peptide
total genus 69
structure length 261
sequence length 261
chains with identical sequence B
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2012-11-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF05033 Pre-SET Pre-SET motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 4i51A00
3DB5A 5ARGA 4NVQA 5F59A 3M58A 4QEOA 3CBMA 5EG2A 4O30A 3OPEA 1XQHA 3S7FA 4IJ8A 3HNAA 5ARFA 1H3IA 5CPRB 3EP0A 4QEPA 2G46A 1N3JA 5F6KC 5HQ8A 3MO2A 4AU7A 3QWWA 5F6LA 5EX0A 5JHNA 2BQZA 4YPAA 5KJLA 5KJKA 2IGQA 3MO0A 4FMUA 3PDNA 2W5YA 3RU0A 1MVXA 3VUZA 4J8OA 3S8PA 3M57A 4C1QA 4J7FA 5EX3A 3SW9A 5KJMA 5LSZA 3TG5A 2R3AA 4RZ0A 5LSXA 5JJ0A 4NJ5A 4LDGA 4YPEA 1N6CA 3RQ4A 5KJNA 5TH7A 4YNMA 5HI7A 2O8JA 5JIYA 4BUPA 2QPWA 1ZKKA 2RFIA 3M5AA 5TEGA 5T0KA 3VV0A 3FPDA 3CBPA 5CCMA 5CCLA 3OXLA 3SWCA 4YNDA 2F69A 3N71A 3BO5A 3QWVA 3S7JA 4E47A 3M55A 3F9XA 3OS5A 3M56A 4YPUA 4H12A 4JDSA 4WUYA 3RJWA 3S7BA 3F9WA 5JINA 3M54A 4JLGA 3M53A 3KMJA 1MUFA 3OXGA 3KMAA 5T5GA 2W5ZA 4IJDA 3QWPA 4MI0A 4Z4PA 3S7DA 3MO5A 3K5KA 5AYFA 4QENA 1MT6A 1PEGA 3MEKA 1ML9A 4I51A 3OXFA 3OOIA 4YNPA 5F5EA 1N6AA 2JV0A 1O9SA 4J7IA 3TG4A 3RAYA 5T0MA 3CBOA 1MVHA 3F9ZA 4O6FA 3RIBA 4MI5A 3M59A 5TTFA 4J83A 3F9YA 3DALA 3IHXA 3KMTA
chains in the Genus database with same CATH superfamily
3DB5A 5ARGA 4NVQA 5F59A 3M58A 4QEOA 3CBMA 5EG2A 4O30A 3OPEA 1XQHA 3S7FA 4IJ8A 3HNAA 5ARFA 1H3IA 5CPRB 3EP0A 4QEPA 2G46A 1N3JA 5F6KC 5HQ8A 3MO2A 4AU7A 3QWWA 5F6LA 5EX0A 5JHNA 2BQZA 4YPAA 5KJLA 5KJKA 2IGQA 3MO0A 4FMUA 3PDNA 2W5YA 3RU0A 1MVXA 3VUZA 4J8OA 3S8PA 3M57A 4C1QA 4J7FA 5EX3A 3SW9A 5KJMA 5LSZA 3TG5A 2R3AA 4RZ0A 5LSXA 5JJ0A 4NJ5A 4LDGA 4YPEA 1N6CA 3RQ4A 5KJNA 5TH7A 4YNMA 5HI7A 2O8JA 5JIYA 4BUPA 2QPWA 1ZKKA 2RFIA 3M5AA 5TEGA 5T0KA 3VV0A 3FPDA 3CBPA 5CCMA 5CCLA 3OXLA 3SWCA 4YNDA 2F69A 3N71A 3BO5A 3QWVA 3S7JA 4E47A 3M55A 3F9XA 3OS5A 3M56A 4YPUA 4H12A 4JDSA 4WUYA 3RJWA 3S7BA 3F9WA 5JINA 3M54A 4JLGA 3M53A 3KMJA 1MUFA 3OXGA 3KMAA 5T5GA 2W5ZA 4IJDA 3QWPA 4MI0A 4Z4PA 3S7DA 3MO5A 3K5KA 5AYFA 4QENA 1MT6A 1PEGA 3MEKA 1ML9A 4I51A 3OXFA 3OOIA 4YNPA 5F5EA 1N6AA 2JV0A 1O9SA 4J7IA 3TG4A 3RAYA 5T0MA 3CBOA 1MVHA 3F9ZA 4O6FA 3RIBA 4MI5A 3M59A 5TTFA 4J83A 3F9YA 3DALA 3IHXA 3KMTA
chains in the Genus database with same CATH topology
3DB5A 5ARGA 4NVQA 5F59A 3M58A 4QEOA 3CBMA 5EG2A 4O30A 3OPEA 1XQHA 3S7FA 4IJ8A 3HNAA 5ARFA 1H3IA 5CPRB 3EP0A 4QEPA 2G46A 1N3JA 5F6KC 5HQ8A 3MO2A 4AU7A 3QWWA 5F6LA 5EX0A 5JHNA 2BQZA 4YPAA 5KJLA 5KJKA 2IGQA 3MO0A 4FMUA 3PDNA 2W5YA 3RU0A 1MVXA 3VUZA 4J8OA 3S8PA 3M57A 4C1QA 4J7FA 5EX3A 3SW9A 5KJMA 5LSZA 3TG5A 2R3AA 4RZ0A 5LSXA 5JJ0A 4NJ5A 4LDGA 4YPEA 1N6CA 3RQ4A 5KJNA 5TH7A 4YNMA 5HI7A 2O8JA 5JIYA 4BUPA 2QPWA 1ZKKA 2RFIA 3M5AA 5TEGA 5T0KA 3VV0A 3FPDA 3CBPA 5CCMA 5CCLA 3OXLA 3SWCA 4YNDA 2F69A 3N71A 3BO5A 3QWVA 3S7JA 4E47A 3M55A 3F9XA 3OS5A 3M56A 4YPUA 4H12A 4JDSA 4WUYA 3RJWA 3S7BA 3F9WA 5JINA 3M54A 4JLGA 3M53A 3KMJA 1MUFA 3OXGA 3KMAA 5T5GA 2W5ZA 4IJDA 3QWPA 4MI0A 4Z4PA 3S7DA 3MO5A 3K5KA 5AYFA 4QENA 1MT6A 1PEGA 3MEKA 1ML9A 4I51A 3OXFA 3OOIA 4YNPA 5F5EA 1N6AA 2JV0A 1O9SA 4J7IA 3TG4A 3RAYA 5T0MA 3CBOA 1MVHA 3F9ZA 4O6FA 3RIBA 4MI5A 3M59A 5TTFA 4J83A 3F9YA 3DALA 3IHXA 3KMTA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3DB5 A;  5ARG A;  4NVQ A;  5F59 A;  3M58 A;  4QEO A;  3CBM A;  5EG2 A;  4O30 A;  3OPE A;  1XQH A;  3S7F A;  4IJ8 A;  3HNA A;  5ARF A;  1H3I A;  5CPR B;  3EP0 A;  4QEP A;  2G46 A;  1N3J A;  5F6K C;  5HQ8 A;  3MO2 A;  4AU7 A;  3QWW A;  5F6L A;  5EX0 A;  5JHN A;  2BQZ A;  4YPA A;  5KJL A;  5KJK A;  2IGQ A;  3MO0 A;  4FMU A;  3PDN A;  2W5Y A;  3RU0 A;  1MVX A;  3VUZ A;  4J8O A;  3S8P A;  3M57 A;  4C1Q A;  4J7F A;  5EX3 A;  3SW9 A;  5KJM A;  5LSZ A;  3TG5 A;  2R3A A;  4RZ0 A;  5LSX A;  5JJ0 A;  4NJ5 A;  4LDG A;  4YPE A;  1N6C A;  3RQ4 A;  5KJN A;  5TH7 A;  4YNM A;  5HI7 A;  2O8J A;  5JIY A;  4BUP A;  2QPW A;  1ZKK A;  2RFI A;  3M5A A;  5TEG A;  5T0K A;  3VV0 A;  3FPD A;  3CBP A;  5CCM A;  5CCL A;  3OXL A;  3SWC A;  4YND A;  2F69 A;  3N71 A;  3BO5 A;  3QWV A;  3S7J A;  4E47 A;  3M55 A;  3F9X A;  3OS5 A;  3M56 A;  4YPU A;  4H12 A;  4JDS A;  4WUY A;  3RJW A;  3S7B A;  3F9W A;  5JIN A;  3M54 A;  4JLG A;  3M53 A;  3KMJ A;  1MUF A;  3OXG A;  3KMA A;  5T5G A;  2W5Z A;  4IJD A;  3QWP A;  4MI0 A;  4Z4P A;  3S7D A;  3MO5 A;  3K5K A;  5AYF A;  4QEN A;  1MT6 A;  1PEG A;  3MEK A;  1ML9 A;  4I51 A;  3OXF A;  3OOI A;  4YNP A;  5F5E A;  1N6A A;  2JV0 A;  1O9S A;  4J7I A;  3TG4 A;  3RAY A;  5T0M A;  3CBO A;  1MVH A;  3F9Z A;  4O6F A;  3RIB A;  4MI5 A;  3M59 A;  5TTF A;  4J83 A;  3F9Y A;  3DAL A;  3IHX A;  3KMT A; 
#chains in the Genus database with same CATH topology
 3DB5 A;  5ARG A;  4NVQ A;  5F59 A;  3M58 A;  4QEO A;  3CBM A;  5EG2 A;  4O30 A;  3OPE A;  1XQH A;  3S7F A;  4IJ8 A;  3HNA A;  5ARF A;  1H3I A;  5CPR B;  3EP0 A;  4QEP A;  2G46 A;  1N3J A;  5F6K C;  5HQ8 A;  3MO2 A;  4AU7 A;  3QWW A;  5F6L A;  5EX0 A;  5JHN A;  2BQZ A;  4YPA A;  5KJL A;  5KJK A;  2IGQ A;  3MO0 A;  4FMU A;  3PDN A;  2W5Y A;  3RU0 A;  1MVX A;  3VUZ A;  4J8O A;  3S8P A;  3M57 A;  4C1Q A;  4J7F A;  5EX3 A;  3SW9 A;  5KJM A;  5LSZ A;  3TG5 A;  2R3A A;  4RZ0 A;  5LSX A;  5JJ0 A;  4NJ5 A;  4LDG A;  4YPE A;  1N6C A;  3RQ4 A;  5KJN A;  5TH7 A;  4YNM A;  5HI7 A;  2O8J A;  5JIY A;  4BUP A;  2QPW A;  1ZKK A;  2RFI A;  3M5A A;  5TEG A;  5T0K A;  3VV0 A;  3FPD A;  3CBP A;  5CCM A;  5CCL A;  3OXL A;  3SWC A;  4YND A;  2F69 A;  3N71 A;  3BO5 A;  3QWV A;  3S7J A;  4E47 A;  3M55 A;  3F9X A;  3OS5 A;  3M56 A;  4YPU A;  4H12 A;  4JDS A;  4WUY A;  3RJW A;  3S7B A;  3F9W A;  5JIN A;  3M54 A;  4JLG A;  3M53 A;  3KMJ A;  1MUF A;  3OXG A;  3KMA A;  5T5G A;  2W5Z A;  4IJD A;  3QWP A;  4MI0 A;  4Z4P A;  3S7D A;  3MO5 A;  3K5K A;  5AYF A;  4QEN A;  1MT6 A;  1PEG A;  3MEK A;  1ML9 A;  4I51 A;  3OXF A;  3OOI A;  4YNP A;  5F5E A;  1N6A A;  2JV0 A;  1O9S A;  4J7I A;  3TG4 A;  3RAY A;  5T0M A;  3CBO A;  1MVH A;  3F9Z A;  4O6F A;  3RIB A;  4MI5 A;  3M59 A;  5TTF A;  4J83 A;  3F9Y A;  3DAL A;  3IHX A;  3KMT A; 
#chains in the Genus database with same CATH homology
 3DB5 A;  5ARG A;  4NVQ A;  5F59 A;  3M58 A;  4QEO A;  3CBM A;  5EG2 A;  4O30 A;  3OPE A;  1XQH A;  3S7F A;  4IJ8 A;  3HNA A;  5ARF A;  1H3I A;  5CPR B;  3EP0 A;  4QEP A;  2G46 A;  1N3J A;  5F6K C;  5HQ8 A;  3MO2 A;  4AU7 A;  3QWW A;  5F6L A;  5EX0 A;  5JHN A;  2BQZ A;  4YPA A;  5KJL A;  5KJK A;  2IGQ A;  3MO0 A;  4FMU A;  3PDN A;  2W5Y A;  3RU0 A;  1MVX A;  3VUZ A;  4J8O A;  3S8P A;  3M57 A;  4C1Q A;  4J7F A;  5EX3 A;  3SW9 A;  5KJM A;  5LSZ A;  3TG5 A;  2R3A A;  4RZ0 A;  5LSX A;  5JJ0 A;  4NJ5 A;  4LDG A;  4YPE A;  1N6C A;  3RQ4 A;  5KJN A;  5TH7 A;  4YNM A;  5HI7 A;  2O8J A;  5JIY A;  4BUP A;  2QPW A;  1ZKK A;  2RFI A;  3M5A A;  5TEG A;  5T0K A;  3VV0 A;  3FPD A;  3CBP A;  5CCM A;  5CCL A;  3OXL A;  3SWC A;  4YND A;  2F69 A;  3N71 A;  3BO5 A;  3QWV A;  3S7J A;  4E47 A;  3M55 A;  3F9X A;  3OS5 A;  3M56 A;  4YPU A;  4H12 A;  4JDS A;  4WUY A;  3RJW A;  3S7B A;  3F9W A;  5JIN A;  3M54 A;  4JLG A;  3M53 A;  3KMJ A;  1MUF A;  3OXG A;  3KMA A;  5T5G A;  2W5Z A;  4IJD A;  3QWP A;  4MI0 A;  4Z4P A;  3S7D A;  3MO5 A;  3K5K A;  5AYF A;  4QEN A;  1MT6 A;  1PEG A;  3MEK A;  1ML9 A;  4I51 A;  3OXF A;  3OOI A;  4YNP A;  5F5E A;  1N6A A;  2JV0 A;  1O9S A;  4J7I A;  3TG4 A;  3RAY A;  5T0M A;  3CBO A;  1MVH A;  3F9Z A;  4O6F A;  3RIB A;  4MI5 A;  3M59 A;  5TTF A;  4J83 A;  3F9Y A;  3DAL A;  3IHX A;  3KMT A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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