3HNAA

Crystal structure of catalytic domain of human euchromatic histone methyltransferase 1 in complex with sah and mono-methylated h3k9 peptide
Total Genus 75
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
75
sequence length
287
structure length
280
Chain Sequence
GSNSQVWSALQMSKALPSPVERIVSRDIARGYERIPIPCVNAVDSEPCPSNYKYVSQNCVTSPMNIDRNITHLQYCVCIDDCSSSNCMCGQLSMRCWYDKDGRLLPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLDNKDGEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIKGKLFSCRCGSPKCRHS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural biology of human H3K9 methyltransferases
pubmed doi rcsb
source organism Homo sapiens
molecule tags Hydrolase/hydrolase regulator
molecule keywords Histone-lysine N-methyltransferase, H3 lysine-9 specific 5
total genus 75
structure length 280
sequence length 287
chains with identical sequence B
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2009-05-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF05033 Pre-SET Pre-SET motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 3hnaA00
5TH7A 1MVXA 3OXGA 3RJWA 3OS5A 3OOIA 3OXFA 1XQHA 3MEKA 3F9YA 3OXLA 3F9XA 3CBPA 3M5AA 4JDSA 3MO2A 1N6CA 3VUZA 3SW9A 4WUYA 3KMAA 5T0KA 3M54A 3EP0A 3QWPA 3OPEA 3N71A 3M59A 2QPWA 5TTFA 4J83A 3M57A 3KMJA 3CBOA 2O8JA 5F6LA 3RIBA 4QEPA 5EX0A 4NJ5A 5EG2A 3S7BA 4NVQA 4I51A 3PDNA 1MVHA 4J7FA 3K5KA 5JIYA 3KMTA 5JJ0A 5HQ8A 3HNAA 3RQ4A 4QEOA 5F6KC 1H3IA 4YNPA 4H12A 3M58A 3CBMA 5T5GA 3FPDA 5LSZA 5KJLA 1N3JA 4LDGA 3TG5A 4QENA 1ZKKA 3S7FA 3QWWA 4MI5A 1MT6A 4J8OA 3SWCA 4BUPA 5HI7A 2IGQA 2F69A 5T0MA 5JHNA 1N6AA 4E47A 5KJKA 2JV0A 1O9SA 4C1QA 4YNMA 2G46A 3DB5A 2W5ZA 4YNDA 5CCMA 5KJNA 3F9WA 3BO5A 3M53A 3MO5A 3M56A 3QWVA 3IHXA 5AYFA 4RZ0A 3S7JA 3RAYA 4YPEA 3MO0A 5F59A 4FMUA 2BQZA 5CCLA 4IJ8A 4JLGA 4O6FA 5JINA 5TEGA 4Z4PA 4YPUA 4AU7A 4J7IA 5KJMA 4IJDA 3DALA 4YPAA 1ML9A 3F9ZA 5ARFA 3RU0A 3TG4A 3VV0A 1MUFA 2W5YA 2R3AA 1PEGA 3S7DA 5CPRB 2RFIA 4MI0A 3S8PA 5ARGA 5EX3A 4O30A 5LSXA 3M55A 5F5EA
chains in the Genus database with same CATH superfamily
5TH7A 1MVXA 3OXGA 3RJWA 3OS5A 3OOIA 3OXFA 1XQHA 3MEKA 3F9YA 3OXLA 3F9XA 3CBPA 3M5AA 4JDSA 3MO2A 1N6CA 3VUZA 3SW9A 4WUYA 3KMAA 5T0KA 3M54A 3EP0A 3QWPA 3OPEA 3N71A 3M59A 2QPWA 5TTFA 4J83A 3M57A 3KMJA 3CBOA 2O8JA 5F6LA 3RIBA 4QEPA 5EX0A 4NJ5A 5EG2A 3S7BA 4NVQA 4I51A 3PDNA 1MVHA 4J7FA 3K5KA 5JIYA 3KMTA 5JJ0A 5HQ8A 3HNAA 3RQ4A 4QEOA 5F6KC 1H3IA 4YNPA 4H12A 3M58A 3CBMA 5T5GA 3FPDA 5LSZA 5KJLA 1N3JA 4LDGA 3TG5A 4QENA 1ZKKA 3S7FA 3QWWA 4MI5A 1MT6A 4J8OA 3SWCA 4BUPA 5HI7A 2IGQA 2F69A 5T0MA 5JHNA 1N6AA 4E47A 5KJKA 2JV0A 1O9SA 4C1QA 4YNMA 2G46A 3DB5A 2W5ZA 4YNDA 5CCMA 5KJNA 3F9WA 3BO5A 3M53A 3MO5A 3M56A 3QWVA 3IHXA 5AYFA 4RZ0A 3S7JA 3RAYA 4YPEA 3MO0A 5F59A 4FMUA 2BQZA 5CCLA 4IJ8A 4JLGA 4O6FA 5JINA 5TEGA 4Z4PA 4YPUA 4AU7A 4J7IA 5KJMA 4IJDA 3DALA 4YPAA 1ML9A 3F9ZA 5ARFA 3RU0A 3TG4A 3VV0A 1MUFA 2W5YA 2R3AA 1PEGA 3S7DA 5CPRB 2RFIA 4MI0A 3S8PA 5ARGA 5EX3A 4O30A 5LSXA 3M55A 5F5EA
chains in the Genus database with same CATH topology
5TH7A 1MVXA 3OXGA 3RJWA 3OS5A 3OOIA 3OXFA 1XQHA 3MEKA 3F9YA 3OXLA 3F9XA 3CBPA 3M5AA 4JDSA 3MO2A 1N6CA 3VUZA 3SW9A 4WUYA 3KMAA 5T0KA 3M54A 3EP0A 3QWPA 3OPEA 3N71A 3M59A 2QPWA 5TTFA 4J83A 3M57A 3KMJA 3CBOA 2O8JA 5F6LA 3RIBA 4QEPA 5EX0A 4NJ5A 5EG2A 3S7BA 4NVQA 4I51A 3PDNA 1MVHA 4J7FA 3K5KA 5JIYA 3KMTA 5JJ0A 5HQ8A 3HNAA 3RQ4A 4QEOA 5F6KC 1H3IA 4YNPA 4H12A 3M58A 3CBMA 5T5GA 3FPDA 5LSZA 5KJLA 1N3JA 4LDGA 3TG5A 4QENA 1ZKKA 3S7FA 3QWWA 4MI5A 1MT6A 4J8OA 3SWCA 4BUPA 5HI7A 2IGQA 2F69A 5T0MA 5JHNA 1N6AA 4E47A 5KJKA 2JV0A 1O9SA 4C1QA 4YNMA 2G46A 3DB5A 2W5ZA 4YNDA 5CCMA 5KJNA 3F9WA 3BO5A 3M53A 3MO5A 3M56A 3QWVA 3IHXA 5AYFA 4RZ0A 3S7JA 3RAYA 4YPEA 3MO0A 5F59A 4FMUA 2BQZA 5CCLA 4IJ8A 4JLGA 4O6FA 5JINA 5TEGA 4Z4PA 4YPUA 4AU7A 4J7IA 5KJMA 4IJDA 3DALA 4YPAA 1ML9A 3F9ZA 5ARFA 3RU0A 3TG4A 3VV0A 1MUFA 2W5YA 2R3AA 1PEGA 3S7DA 5CPRB 2RFIA 4MI0A 3S8PA 5ARGA 5EX3A 4O30A 5LSXA 3M55A 5F5EA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5TH7 A;  1MVX A;  3OXG A;  3RJW A;  3OS5 A;  3OOI A;  3OXF A;  1XQH A;  3MEK A;  3F9Y A;  3OXL A;  3F9X A;  3CBP A;  3M5A A;  4JDS A;  3MO2 A;  1N6C A;  3VUZ A;  3SW9 A;  4WUY A;  3KMA A;  5T0K A;  3M54 A;  3EP0 A;  3QWP A;  3OPE A;  3N71 A;  3M59 A;  2QPW A;  5TTF A;  4J83 A;  3M57 A;  3KMJ A;  3CBO A;  2O8J A;  5F6L A;  3RIB A;  4QEP A;  5EX0 A;  4NJ5 A;  5EG2 A;  3S7B A;  4NVQ A;  4I51 A;  3PDN A;  1MVH A;  4J7F A;  3K5K A;  5JIY A;  3KMT A;  5JJ0 A;  5HQ8 A;  3HNA A;  3RQ4 A;  4QEO A;  5F6K C;  1H3I A;  4YNP A;  4H12 A;  3M58 A;  3CBM A;  5T5G A;  3FPD A;  5LSZ A;  5KJL A;  1N3J A;  4LDG A;  3TG5 A;  4QEN A;  1ZKK A;  3S7F A;  3QWW A;  4MI5 A;  1MT6 A;  4J8O A;  3SWC A;  4BUP A;  5HI7 A;  2IGQ A;  2F69 A;  5T0M A;  5JHN A;  1N6A A;  4E47 A;  5KJK A;  2JV0 A;  1O9S A;  4C1Q A;  4YNM A;  2G46 A;  3DB5 A;  2W5Z A;  4YND A;  5CCM A;  5KJN A;  3F9W A;  3BO5 A;  3M53 A;  3MO5 A;  3M56 A;  3QWV A;  3IHX A;  5AYF A;  4RZ0 A;  3S7J A;  3RAY A;  4YPE A;  3MO0 A;  5F59 A;  4FMU A;  2BQZ A;  5CCL A;  4IJ8 A;  4JLG A;  4O6F A;  5JIN A;  5TEG A;  4Z4P A;  4YPU A;  4AU7 A;  4J7I A;  5KJM A;  4IJD A;  3DAL A;  4YPA A;  1ML9 A;  3F9Z A;  5ARF A;  3RU0 A;  3TG4 A;  3VV0 A;  1MUF A;  2W5Y A;  2R3A A;  1PEG A;  3S7D A;  5CPR B;  2RFI A;  4MI0 A;  3S8P A;  5ARG A;  5EX3 A;  4O30 A;  5LSX A;  3M55 A;  5F5E A; 
#chains in the Genus database with same CATH topology
 5TH7 A;  1MVX A;  3OXG A;  3RJW A;  3OS5 A;  3OOI A;  3OXF A;  1XQH A;  3MEK A;  3F9Y A;  3OXL A;  3F9X A;  3CBP A;  3M5A A;  4JDS A;  3MO2 A;  1N6C A;  3VUZ A;  3SW9 A;  4WUY A;  3KMA A;  5T0K A;  3M54 A;  3EP0 A;  3QWP A;  3OPE A;  3N71 A;  3M59 A;  2QPW A;  5TTF A;  4J83 A;  3M57 A;  3KMJ A;  3CBO A;  2O8J A;  5F6L A;  3RIB A;  4QEP A;  5EX0 A;  4NJ5 A;  5EG2 A;  3S7B A;  4NVQ A;  4I51 A;  3PDN A;  1MVH A;  4J7F A;  3K5K A;  5JIY A;  3KMT A;  5JJ0 A;  5HQ8 A;  3HNA A;  3RQ4 A;  4QEO A;  5F6K C;  1H3I A;  4YNP A;  4H12 A;  3M58 A;  3CBM A;  5T5G A;  3FPD A;  5LSZ A;  5KJL A;  1N3J A;  4LDG A;  3TG5 A;  4QEN A;  1ZKK A;  3S7F A;  3QWW A;  4MI5 A;  1MT6 A;  4J8O A;  3SWC A;  4BUP A;  5HI7 A;  2IGQ A;  2F69 A;  5T0M A;  5JHN A;  1N6A A;  4E47 A;  5KJK A;  2JV0 A;  1O9S A;  4C1Q A;  4YNM A;  2G46 A;  3DB5 A;  2W5Z A;  4YND A;  5CCM A;  5KJN A;  3F9W A;  3BO5 A;  3M53 A;  3MO5 A;  3M56 A;  3QWV A;  3IHX A;  5AYF A;  4RZ0 A;  3S7J A;  3RAY A;  4YPE A;  3MO0 A;  5F59 A;  4FMU A;  2BQZ A;  5CCL A;  4IJ8 A;  4JLG A;  4O6F A;  5JIN A;  5TEG A;  4Z4P A;  4YPU A;  4AU7 A;  4J7I A;  5KJM A;  4IJD A;  3DAL A;  4YPA A;  1ML9 A;  3F9Z A;  5ARF A;  3RU0 A;  3TG4 A;  3VV0 A;  1MUF A;  2W5Y A;  2R3A A;  1PEG A;  3S7D A;  5CPR B;  2RFI A;  4MI0 A;  3S8P A;  5ARG A;  5EX3 A;  4O30 A;  5LSX A;  3M55 A;  5F5E A; 
#chains in the Genus database with same CATH homology
 5TH7 A;  1MVX A;  3OXG A;  3RJW A;  3OS5 A;  3OOI A;  3OXF A;  1XQH A;  3MEK A;  3F9Y A;  3OXL A;  3F9X A;  3CBP A;  3M5A A;  4JDS A;  3MO2 A;  1N6C A;  3VUZ A;  3SW9 A;  4WUY A;  3KMA A;  5T0K A;  3M54 A;  3EP0 A;  3QWP A;  3OPE A;  3N71 A;  3M59 A;  2QPW A;  5TTF A;  4J83 A;  3M57 A;  3KMJ A;  3CBO A;  2O8J A;  5F6L A;  3RIB A;  4QEP A;  5EX0 A;  4NJ5 A;  5EG2 A;  3S7B A;  4NVQ A;  4I51 A;  3PDN A;  1MVH A;  4J7F A;  3K5K A;  5JIY A;  3KMT A;  5JJ0 A;  5HQ8 A;  3HNA A;  3RQ4 A;  4QEO A;  5F6K C;  1H3I A;  4YNP A;  4H12 A;  3M58 A;  3CBM A;  5T5G A;  3FPD A;  5LSZ A;  5KJL A;  1N3J A;  4LDG A;  3TG5 A;  4QEN A;  1ZKK A;  3S7F A;  3QWW A;  4MI5 A;  1MT6 A;  4J8O A;  3SWC A;  4BUP A;  5HI7 A;  2IGQ A;  2F69 A;  5T0M A;  5JHN A;  1N6A A;  4E47 A;  5KJK A;  2JV0 A;  1O9S A;  4C1Q A;  4YNM A;  2G46 A;  3DB5 A;  2W5Z A;  4YND A;  5CCM A;  5KJN A;  3F9W A;  3BO5 A;  3M53 A;  3MO5 A;  3M56 A;  3QWV A;  3IHX A;  5AYF A;  4RZ0 A;  3S7J A;  3RAY A;  4YPE A;  3MO0 A;  5F59 A;  4FMU A;  2BQZ A;  5CCL A;  4IJ8 A;  4JLG A;  4O6F A;  5JIN A;  5TEG A;  4Z4P A;  4YPU A;  4AU7 A;  4J7I A;  5KJM A;  4IJD A;  3DAL A;  4YPA A;  1ML9 A;  3F9Z A;  5ARF A;  3RU0 A;  3TG4 A;  3VV0 A;  1MUF A;  2W5Y A;  2R3A A;  1PEG A;  3S7D A;  5CPR B;  2RFI A;  4MI0 A;  3S8P A;  5ARG A;  5EX3 A;  4O30 A;  5LSX A;  3M55 A;  5F5E A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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