3HNAA

Crystal structure of catalytic domain of human euchromatic histone methyltransferase 1 in complex with sah and mono-methylated h3k9 peptide
Total Genus 75
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
75
sequence length
287
structure length
280
Chain Sequence
b'GSNSQVWSALQMSKALPSPVERIVSRDIARGYERIPIPCVNAVDSEPCPSNYKYVSQNCVTSPMNIDRNITHLQYCVCIDDCSSSNCMCGQLSMRCWYDKDGRLLPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLDNKDGEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIKGKLFSCRCGSPKCRHS'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Histone-lysine N-methyltransferase, H3 lysine-9 specific 5
publication title Structural biology of human H3K9 methyltransferases
pubmed doi rcsb
source organism Homo sapiens
molecule tags Hydrolase/hydrolase regulator
total genus 75
structure length 280
sequence length 287
chains with identical sequence B
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2009-05-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF05033 Pre-SET Pre-SET motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 3hnaA00
3FPDA 5ARFA 3M57A 1PEGA 3MO0A 5F5EA 3OOIA 4YPUA 4WUYA 3RJWA 5ARGA 5JINA 3VV0A 4NVQA 5HQ8A 4IJ8A 3EP0A 5KJNA 3F9YA 2IGQA 1O9SA 5JJ0A 5TH7A 1H3IA 3RQ4A 3M56A 3RAYA 3SWCA 1ML9A 3S7DA 3S7BA 3S7FA 3CBMA 5AYFA 3TG4A 4RZ0A 1XQHA 3OXGA 4MI0A 3M5AA 4JDSA 5F6LA 4FMUA 5T0KA 4J83A 3DB5A 4O30A 5EG2A 3M54A 3MO2A 3M58A 5F59A 3F9WA 4J7IA 3N71A 5HI7A 4YNDA 3KMTA 5CPRB 3VUZA 5T5GA 5JIYA 4IJDA 3PDNA 4C1QA 3KMJA 4NJ5A 4QEOA 3MO5A 4JLGA 5CCLA 5CCMA 3F9ZA 5KJMA 4YPEA 1N6CA 3DALA 4AU7A 2W5ZA 2O8JA 3OPEA 2G46A 4O6FA 3OXLA 4Z4PA 4H12A 4QEPA 3S8PA 5LSXA 3M53A 1MT6A 2JV0A 3QWVA 3SW9A 5JHNA 1N6AA 1N3JA 4E47A 5LSZA 3M59A 1MVXA 3MEKA 5T0MA 3TG5A 3OS5A 2QPWA 4QENA 2W5YA 1MUFA 3QWPA 3QWWA 3KMAA 5TEGA 2F69A 3OXFA 4J8OA 5F6KC 3F9XA 1ZKKA 3BO5A 4MI5A 3IHXA 3RIBA 4J7FA 2R3AA 3CBOA 1MVHA 4YPAA 5EX0A 2BQZA 2RFIA 4LDGA 5KJLA 4YNPA 3RU0A 5KJKA 5TTFA 3K5KA 4YNMA 4BUPA 3HNAA 3M55A 4I51A 5EX3A 3S7JA 3CBPA
chains in the Genus database with same CATH superfamily
3FPDA 5ARFA 3M57A 1PEGA 3MO0A 5F5EA 3OOIA 4YPUA 4WUYA 3RJWA 5ARGA 5JINA 3VV0A 4NVQA 5HQ8A 4IJ8A 3EP0A 5KJNA 3F9YA 2IGQA 1O9SA 5JJ0A 5TH7A 1H3IA 3RQ4A 3M56A 3RAYA 3SWCA 1ML9A 3S7DA 3S7BA 3S7FA 3CBMA 5AYFA 3TG4A 4RZ0A 1XQHA 3OXGA 4MI0A 3M5AA 4JDSA 5F6LA 4FMUA 5T0KA 4J83A 3DB5A 4O30A 5EG2A 3M54A 3MO2A 3M58A 5F59A 3F9WA 4J7IA 3N71A 5HI7A 4YNDA 3KMTA 5CPRB 3VUZA 5T5GA 5JIYA 4IJDA 3PDNA 4C1QA 3KMJA 4NJ5A 4QEOA 3MO5A 4JLGA 5CCLA 5CCMA 3F9ZA 5KJMA 4YPEA 1N6CA 3DALA 4AU7A 2W5ZA 2O8JA 3OPEA 2G46A 4O6FA 3OXLA 4Z4PA 4H12A 4QEPA 3S8PA 5LSXA 3M53A 1MT6A 2JV0A 3QWVA 3SW9A 5JHNA 1N6AA 1N3JA 4E47A 5LSZA 3M59A 1MVXA 3MEKA 5T0MA 3TG5A 3OS5A 2QPWA 4QENA 2W5YA 1MUFA 3QWPA 3QWWA 3KMAA 5TEGA 2F69A 3OXFA 4J8OA 5F6KC 3F9XA 1ZKKA 3BO5A 4MI5A 3IHXA 3RIBA 4J7FA 2R3AA 3CBOA 1MVHA 4YPAA 5EX0A 2BQZA 2RFIA 4LDGA 5KJLA 4YNPA 3RU0A 5KJKA 5TTFA 3K5KA 4YNMA 4BUPA 3HNAA 3M55A 4I51A 5EX3A 3S7JA 3CBPA
chains in the Genus database with same CATH topology
3FPDA 5ARFA 3M57A 1PEGA 3MO0A 5F5EA 3OOIA 4YPUA 4WUYA 3RJWA 5ARGA 5JINA 3VV0A 4NVQA 5HQ8A 4IJ8A 3EP0A 5KJNA 3F9YA 2IGQA 1O9SA 5JJ0A 5TH7A 1H3IA 3RQ4A 3M56A 3RAYA 3SWCA 1ML9A 3S7DA 3S7BA 3S7FA 3CBMA 5AYFA 3TG4A 4RZ0A 1XQHA 3OXGA 4MI0A 3M5AA 4JDSA 5F6LA 4FMUA 5T0KA 4J83A 3DB5A 4O30A 5EG2A 3M54A 3MO2A 3M58A 5F59A 3F9WA 4J7IA 3N71A 5HI7A 4YNDA 3KMTA 5CPRB 3VUZA 5T5GA 5JIYA 4IJDA 3PDNA 4C1QA 3KMJA 4NJ5A 4QEOA 3MO5A 4JLGA 5CCLA 5CCMA 3F9ZA 5KJMA 4YPEA 1N6CA 3DALA 4AU7A 2W5ZA 2O8JA 3OPEA 2G46A 4O6FA 3OXLA 4Z4PA 4H12A 4QEPA 3S8PA 5LSXA 3M53A 1MT6A 2JV0A 3QWVA 3SW9A 5JHNA 1N6AA 1N3JA 4E47A 5LSZA 3M59A 1MVXA 3MEKA 5T0MA 3TG5A 3OS5A 2QPWA 4QENA 2W5YA 1MUFA 3QWPA 3QWWA 3KMAA 5TEGA 2F69A 3OXFA 4J8OA 5F6KC 3F9XA 1ZKKA 3BO5A 4MI5A 3IHXA 3RIBA 4J7FA 2R3AA 3CBOA 1MVHA 4YPAA 5EX0A 2BQZA 2RFIA 4LDGA 5KJLA 4YNPA 3RU0A 5KJKA 5TTFA 3K5KA 4YNMA 4BUPA 3HNAA 3M55A 4I51A 5EX3A 3S7JA 3CBPA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3FPD A;  5ARF A;  3M57 A;  1PEG A;  3MO0 A;  5F5E A;  3OOI A;  4YPU A;  4WUY A;  3RJW A;  5ARG A;  5JIN A;  3VV0 A;  4NVQ A;  5HQ8 A;  4IJ8 A;  3EP0 A;  5KJN A;  3F9Y A;  2IGQ A;  1O9S A;  5JJ0 A;  5TH7 A;  1H3I A;  3RQ4 A;  3M56 A;  3RAY A;  3SWC A;  1ML9 A;  3S7D A;  3S7B A;  3S7F A;  3CBM A;  5AYF A;  3TG4 A;  4RZ0 A;  1XQH A;  3OXG A;  4MI0 A;  3M5A A;  4JDS A;  5F6L A;  4FMU A;  5T0K A;  4J83 A;  3DB5 A;  4O30 A;  5EG2 A;  3M54 A;  3MO2 A;  3M58 A;  5F59 A;  3F9W A;  4J7I A;  3N71 A;  5HI7 A;  4YND A;  3KMT A;  5CPR B;  3VUZ A;  5T5G A;  5JIY A;  4IJD A;  3PDN A;  4C1Q A;  3KMJ A;  4NJ5 A;  4QEO A;  3MO5 A;  4JLG A;  5CCL A;  5CCM A;  3F9Z A;  5KJM A;  4YPE A;  1N6C A;  3DAL A;  4AU7 A;  2W5Z A;  2O8J A;  3OPE A;  2G46 A;  4O6F A;  3OXL A;  4Z4P A;  4H12 A;  4QEP A;  3S8P A;  5LSX A;  3M53 A;  1MT6 A;  2JV0 A;  3QWV A;  3SW9 A;  5JHN A;  1N6A A;  1N3J A;  4E47 A;  5LSZ A;  3M59 A;  1MVX A;  3MEK A;  5T0M A;  3TG5 A;  3OS5 A;  2QPW A;  4QEN A;  2W5Y A;  1MUF A;  3QWP A;  3QWW A;  3KMA A;  5TEG A;  2F69 A;  3OXF A;  4J8O A;  5F6K C;  3F9X A;  1ZKK A;  3BO5 A;  4MI5 A;  3IHX A;  3RIB A;  4J7F A;  2R3A A;  3CBO A;  1MVH A;  4YPA A;  5EX0 A;  2BQZ A;  2RFI A;  4LDG A;  5KJL A;  4YNP A;  3RU0 A;  5KJK A;  5TTF A;  3K5K A;  4YNM A;  4BUP A;  3HNA A;  3M55 A;  4I51 A;  5EX3 A;  3S7J A;  3CBP A; 
#chains in the Genus database with same CATH topology
 3FPD A;  5ARF A;  3M57 A;  1PEG A;  3MO0 A;  5F5E A;  3OOI A;  4YPU A;  4WUY A;  3RJW A;  5ARG A;  5JIN A;  3VV0 A;  4NVQ A;  5HQ8 A;  4IJ8 A;  3EP0 A;  5KJN A;  3F9Y A;  2IGQ A;  1O9S A;  5JJ0 A;  5TH7 A;  1H3I A;  3RQ4 A;  3M56 A;  3RAY A;  3SWC A;  1ML9 A;  3S7D A;  3S7B A;  3S7F A;  3CBM A;  5AYF A;  3TG4 A;  4RZ0 A;  1XQH A;  3OXG A;  4MI0 A;  3M5A A;  4JDS A;  5F6L A;  4FMU A;  5T0K A;  4J83 A;  3DB5 A;  4O30 A;  5EG2 A;  3M54 A;  3MO2 A;  3M58 A;  5F59 A;  3F9W A;  4J7I A;  3N71 A;  5HI7 A;  4YND A;  3KMT A;  5CPR B;  3VUZ A;  5T5G A;  5JIY A;  4IJD A;  3PDN A;  4C1Q A;  3KMJ A;  4NJ5 A;  4QEO A;  3MO5 A;  4JLG A;  5CCL A;  5CCM A;  3F9Z A;  5KJM A;  4YPE A;  1N6C A;  3DAL A;  4AU7 A;  2W5Z A;  2O8J A;  3OPE A;  2G46 A;  4O6F A;  3OXL A;  4Z4P A;  4H12 A;  4QEP A;  3S8P A;  5LSX A;  3M53 A;  1MT6 A;  2JV0 A;  3QWV A;  3SW9 A;  5JHN A;  1N6A A;  1N3J A;  4E47 A;  5LSZ A;  3M59 A;  1MVX A;  3MEK A;  5T0M A;  3TG5 A;  3OS5 A;  2QPW A;  4QEN A;  2W5Y A;  1MUF A;  3QWP A;  3QWW A;  3KMA A;  5TEG A;  2F69 A;  3OXF A;  4J8O A;  5F6K C;  3F9X A;  1ZKK A;  3BO5 A;  4MI5 A;  3IHX A;  3RIB A;  4J7F A;  2R3A A;  3CBO A;  1MVH A;  4YPA A;  5EX0 A;  2BQZ A;  2RFI A;  4LDG A;  5KJL A;  4YNP A;  3RU0 A;  5KJK A;  5TTF A;  3K5K A;  4YNM A;  4BUP A;  3HNA A;  3M55 A;  4I51 A;  5EX3 A;  3S7J A;  3CBP A; 
#chains in the Genus database with same CATH homology
 3FPD A;  5ARF A;  3M57 A;  1PEG A;  3MO0 A;  5F5E A;  3OOI A;  4YPU A;  4WUY A;  3RJW A;  5ARG A;  5JIN A;  3VV0 A;  4NVQ A;  5HQ8 A;  4IJ8 A;  3EP0 A;  5KJN A;  3F9Y A;  2IGQ A;  1O9S A;  5JJ0 A;  5TH7 A;  1H3I A;  3RQ4 A;  3M56 A;  3RAY A;  3SWC A;  1ML9 A;  3S7D A;  3S7B A;  3S7F A;  3CBM A;  5AYF A;  3TG4 A;  4RZ0 A;  1XQH A;  3OXG A;  4MI0 A;  3M5A A;  4JDS A;  5F6L A;  4FMU A;  5T0K A;  4J83 A;  3DB5 A;  4O30 A;  5EG2 A;  3M54 A;  3MO2 A;  3M58 A;  5F59 A;  3F9W A;  4J7I A;  3N71 A;  5HI7 A;  4YND A;  3KMT A;  5CPR B;  3VUZ A;  5T5G A;  5JIY A;  4IJD A;  3PDN A;  4C1Q A;  3KMJ A;  4NJ5 A;  4QEO A;  3MO5 A;  4JLG A;  5CCL A;  5CCM A;  3F9Z A;  5KJM A;  4YPE A;  1N6C A;  3DAL A;  4AU7 A;  2W5Z A;  2O8J A;  3OPE A;  2G46 A;  4O6F A;  3OXL A;  4Z4P A;  4H12 A;  4QEP A;  3S8P A;  5LSX A;  3M53 A;  1MT6 A;  2JV0 A;  3QWV A;  3SW9 A;  5JHN A;  1N6A A;  1N3J A;  4E47 A;  5LSZ A;  3M59 A;  1MVX A;  3MEK A;  5T0M A;  3TG5 A;  3OS5 A;  2QPW A;  4QEN A;  2W5Y A;  1MUF A;  3QWP A;  3QWW A;  3KMA A;  5TEG A;  2F69 A;  3OXF A;  4J8O A;  5F6K C;  3F9X A;  1ZKK A;  3BO5 A;  4MI5 A;  3IHX A;  3RIB A;  4J7F A;  2R3A A;  3CBO A;  1MVH A;  4YPA A;  5EX0 A;  2BQZ A;  2RFI A;  4LDG A;  5KJL A;  4YNP A;  3RU0 A;  5KJK A;  5TTF A;  3K5K A;  4YNM A;  4BUP A;  3HNA A;  3M55 A;  4I51 A;  5EX3 A;  3S7J A;  3CBP A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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