3HNAA

Crystal structure of catalytic domain of human euchromatic histone methyltransferase 1 in complex with sah and mono-methylated h3k9 peptide
Total Genus 75
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
75
sequence length
287
structure length
280
Chain Sequence
GSNSQVWSALQMSKALPSPVERIVSRDIARGYERIPIPCVNAVDSEPCPSNYKYVSQNCVTSPMNIDRNITHLQYCVCIDDCSSSNCMCGQLSMRCWYDKDGRLLPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLDNKDGEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIKGKLFSCRCGSPKCRHS
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase/hydrolase regulator
molecule keywords Histone-lysine N-methyltransferase, H3 lysine-9 specific 5
publication title Structural biology of human H3K9 methyltransferases
pubmed doi rcsb
source organism Homo sapiens
total genus 75
structure length 280
sequence length 287
chains with identical sequence B
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2009-05-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF05033 Pre-SET Pre-SET motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 3hnaA00
4FMUA 3M5AA 3S7DA 3S7JA 4O30A 3RAYA 2O8JA 4LDGA 1ZKKA 5CCLA 1N3JA 3M59A 5EX3A 2BQZA 1ML9A 2W5ZA 5F6KC 3BO5A 4H12A 3CBMA 1N6CA 1O9SA 3S8PA 3DALA 4O6FA 3VUZA 5AYFA 2W5YA 4JDSA 3S7FA 1XQHA 5JINA 5CPRB 3M53A 5T0MA 3DB5A 2G46A 4YPEA 3F9YA 5KJMA 4MI0A 4AU7A 3OPEA 3TG5A 4YNPA 4JLGA 3MEKA 3RQ4A 3IHXA 3M56A 5KJNA 3OS5A 5TEGA 3RU0A 5HQ8A 3MO2A 1MVXA 5JHNA 2R3AA 3KMJA 5TTFA 3CBPA 3M54A 3RJWA 4J8OA 3N71A 3MO5A 4BUPA 4YPAA 3FPDA 2F69A 3QWWA 3OXLA 3OXFA 3RIBA 5ARFA 5F59A 4WUYA 4MI5A 1MT6A 3OXGA 3M58A 4QEOA 1H3IA 3HNAA 5JIYA 3VV0A 3EP0A 3MO0A 4Z4PA 4J7FA 3S7BA 2IGQA 2RFIA 3KMTA 5F6LA 4QEPA 5EX0A 3M57A 3OOIA 3F9WA 1MVHA 5LSXA 5KJKA 5CCMA 4NVQA 4YNMA 5T5GA 4I51A 3QWVA 5EG2A 3SWCA 1PEGA 2JV0A 5ARGA 5T0KA 3SW9A 3CBOA 4J7IA 5LSZA 3K5KA 4YPUA 1N6AA 4YNDA 5KJLA 3KMAA 2QPWA 4C1QA 4IJ8A 3TG4A 3PDNA 1MUFA 3F9ZA 5HI7A 4QENA 4J83A 3QWPA 3F9XA 4E47A 5JJ0A 4IJDA 5F5EA 4RZ0A 3M55A 5TH7A 4NJ5A
chains in the Genus database with same CATH superfamily
4FMUA 3M5AA 3S7DA 3S7JA 4O30A 3RAYA 2O8JA 4LDGA 1ZKKA 5CCLA 1N3JA 3M59A 5EX3A 2BQZA 1ML9A 2W5ZA 5F6KC 3BO5A 4H12A 3CBMA 1N6CA 1O9SA 3S8PA 3DALA 4O6FA 3VUZA 5AYFA 2W5YA 4JDSA 3S7FA 1XQHA 5JINA 5CPRB 3M53A 5T0MA 3DB5A 2G46A 4YPEA 3F9YA 5KJMA 4MI0A 4AU7A 3OPEA 3TG5A 4YNPA 4JLGA 3MEKA 3RQ4A 3IHXA 3M56A 5KJNA 3OS5A 5TEGA 3RU0A 5HQ8A 3MO2A 1MVXA 5JHNA 2R3AA 3KMJA 5TTFA 3CBPA 3M54A 3RJWA 4J8OA 3N71A 3MO5A 4BUPA 4YPAA 3FPDA 2F69A 3QWWA 3OXLA 3OXFA 3RIBA 5ARFA 5F59A 4WUYA 4MI5A 1MT6A 3OXGA 3M58A 4QEOA 1H3IA 3HNAA 5JIYA 3VV0A 3EP0A 3MO0A 4Z4PA 4J7FA 3S7BA 2IGQA 2RFIA 3KMTA 5F6LA 4QEPA 5EX0A 3M57A 3OOIA 3F9WA 1MVHA 5LSXA 5KJKA 5CCMA 4NVQA 4YNMA 5T5GA 4I51A 3QWVA 5EG2A 3SWCA 1PEGA 2JV0A 5ARGA 5T0KA 3SW9A 3CBOA 4J7IA 5LSZA 3K5KA 4YPUA 1N6AA 4YNDA 5KJLA 3KMAA 2QPWA 4C1QA 4IJ8A 3TG4A 3PDNA 1MUFA 3F9ZA 5HI7A 4QENA 4J83A 3QWPA 3F9XA 4E47A 5JJ0A 4IJDA 5F5EA 4RZ0A 3M55A 5TH7A 4NJ5A
chains in the Genus database with same CATH topology
4FMUA 3M5AA 3S7DA 3S7JA 4O30A 3RAYA 2O8JA 4LDGA 1ZKKA 5CCLA 1N3JA 3M59A 5EX3A 2BQZA 1ML9A 2W5ZA 5F6KC 3BO5A 4H12A 3CBMA 1N6CA 1O9SA 3S8PA 3DALA 4O6FA 3VUZA 5AYFA 2W5YA 4JDSA 3S7FA 1XQHA 5JINA 5CPRB 3M53A 5T0MA 3DB5A 2G46A 4YPEA 3F9YA 5KJMA 4MI0A 4AU7A 3OPEA 3TG5A 4YNPA 4JLGA 3MEKA 3RQ4A 3IHXA 3M56A 5KJNA 3OS5A 5TEGA 3RU0A 5HQ8A 3MO2A 1MVXA 5JHNA 2R3AA 3KMJA 5TTFA 3CBPA 3M54A 3RJWA 4J8OA 3N71A 3MO5A 4BUPA 4YPAA 3FPDA 2F69A 3QWWA 3OXLA 3OXFA 3RIBA 5ARFA 5F59A 4WUYA 4MI5A 1MT6A 3OXGA 3M58A 4QEOA 1H3IA 3HNAA 5JIYA 3VV0A 3EP0A 3MO0A 4Z4PA 4J7FA 3S7BA 2IGQA 2RFIA 3KMTA 5F6LA 4QEPA 5EX0A 3M57A 3OOIA 3F9WA 1MVHA 5LSXA 5KJKA 5CCMA 4NVQA 4YNMA 5T5GA 4I51A 3QWVA 5EG2A 3SWCA 1PEGA 2JV0A 5ARGA 5T0KA 3SW9A 3CBOA 4J7IA 5LSZA 3K5KA 4YPUA 1N6AA 4YNDA 5KJLA 3KMAA 2QPWA 4C1QA 4IJ8A 3TG4A 3PDNA 1MUFA 3F9ZA 5HI7A 4QENA 4J83A 3QWPA 3F9XA 4E47A 5JJ0A 4IJDA 5F5EA 4RZ0A 3M55A 5TH7A 4NJ5A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4FMU A;  3M5A A;  3S7D A;  3S7J A;  4O30 A;  3RAY A;  2O8J A;  4LDG A;  1ZKK A;  5CCL A;  1N3J A;  3M59 A;  5EX3 A;  2BQZ A;  1ML9 A;  2W5Z A;  5F6K C;  3BO5 A;  4H12 A;  3CBM A;  1N6C A;  1O9S A;  3S8P A;  3DAL A;  4O6F A;  3VUZ A;  5AYF A;  2W5Y A;  4JDS A;  3S7F A;  1XQH A;  5JIN A;  5CPR B;  3M53 A;  5T0M A;  3DB5 A;  2G46 A;  4YPE A;  3F9Y A;  5KJM A;  4MI0 A;  4AU7 A;  3OPE A;  3TG5 A;  4YNP A;  4JLG A;  3MEK A;  3RQ4 A;  3IHX A;  3M56 A;  5KJN A;  3OS5 A;  5TEG A;  3RU0 A;  5HQ8 A;  3MO2 A;  1MVX A;  5JHN A;  2R3A A;  3KMJ A;  5TTF A;  3CBP A;  3M54 A;  3RJW A;  4J8O A;  3N71 A;  3MO5 A;  4BUP A;  4YPA A;  3FPD A;  2F69 A;  3QWW A;  3OXL A;  3OXF A;  3RIB A;  5ARF A;  5F59 A;  4WUY A;  4MI5 A;  1MT6 A;  3OXG A;  3M58 A;  4QEO A;  1H3I A;  3HNA A;  5JIY A;  3VV0 A;  3EP0 A;  3MO0 A;  4Z4P A;  4J7F A;  3S7B A;  2IGQ A;  2RFI A;  3KMT A;  5F6L A;  4QEP A;  5EX0 A;  3M57 A;  3OOI A;  3F9W A;  1MVH A;  5LSX A;  5KJK A;  5CCM A;  4NVQ A;  4YNM A;  5T5G A;  4I51 A;  3QWV A;  5EG2 A;  3SWC A;  1PEG A;  2JV0 A;  5ARG A;  5T0K A;  3SW9 A;  3CBO A;  4J7I A;  5LSZ A;  3K5K A;  4YPU A;  1N6A A;  4YND A;  5KJL A;  3KMA A;  2QPW A;  4C1Q A;  4IJ8 A;  3TG4 A;  3PDN A;  1MUF A;  3F9Z A;  5HI7 A;  4QEN A;  4J83 A;  3QWP A;  3F9X A;  4E47 A;  5JJ0 A;  4IJD A;  5F5E A;  4RZ0 A;  3M55 A;  5TH7 A;  4NJ5 A; 
#chains in the Genus database with same CATH topology
 4FMU A;  3M5A A;  3S7D A;  3S7J A;  4O30 A;  3RAY A;  2O8J A;  4LDG A;  1ZKK A;  5CCL A;  1N3J A;  3M59 A;  5EX3 A;  2BQZ A;  1ML9 A;  2W5Z A;  5F6K C;  3BO5 A;  4H12 A;  3CBM A;  1N6C A;  1O9S A;  3S8P A;  3DAL A;  4O6F A;  3VUZ A;  5AYF A;  2W5Y A;  4JDS A;  3S7F A;  1XQH A;  5JIN A;  5CPR B;  3M53 A;  5T0M A;  3DB5 A;  2G46 A;  4YPE A;  3F9Y A;  5KJM A;  4MI0 A;  4AU7 A;  3OPE A;  3TG5 A;  4YNP A;  4JLG A;  3MEK A;  3RQ4 A;  3IHX A;  3M56 A;  5KJN A;  3OS5 A;  5TEG A;  3RU0 A;  5HQ8 A;  3MO2 A;  1MVX A;  5JHN A;  2R3A A;  3KMJ A;  5TTF A;  3CBP A;  3M54 A;  3RJW A;  4J8O A;  3N71 A;  3MO5 A;  4BUP A;  4YPA A;  3FPD A;  2F69 A;  3QWW A;  3OXL A;  3OXF A;  3RIB A;  5ARF A;  5F59 A;  4WUY A;  4MI5 A;  1MT6 A;  3OXG A;  3M58 A;  4QEO A;  1H3I A;  3HNA A;  5JIY A;  3VV0 A;  3EP0 A;  3MO0 A;  4Z4P A;  4J7F A;  3S7B A;  2IGQ A;  2RFI A;  3KMT A;  5F6L A;  4QEP A;  5EX0 A;  3M57 A;  3OOI A;  3F9W A;  1MVH A;  5LSX A;  5KJK A;  5CCM A;  4NVQ A;  4YNM A;  5T5G A;  4I51 A;  3QWV A;  5EG2 A;  3SWC A;  1PEG A;  2JV0 A;  5ARG A;  5T0K A;  3SW9 A;  3CBO A;  4J7I A;  5LSZ A;  3K5K A;  4YPU A;  1N6A A;  4YND A;  5KJL A;  3KMA A;  2QPW A;  4C1Q A;  4IJ8 A;  3TG4 A;  3PDN A;  1MUF A;  3F9Z A;  5HI7 A;  4QEN A;  4J83 A;  3QWP A;  3F9X A;  4E47 A;  5JJ0 A;  4IJD A;  5F5E A;  4RZ0 A;  3M55 A;  5TH7 A;  4NJ5 A; 
#chains in the Genus database with same CATH homology
 4FMU A;  3M5A A;  3S7D A;  3S7J A;  4O30 A;  3RAY A;  2O8J A;  4LDG A;  1ZKK A;  5CCL A;  1N3J A;  3M59 A;  5EX3 A;  2BQZ A;  1ML9 A;  2W5Z A;  5F6K C;  3BO5 A;  4H12 A;  3CBM A;  1N6C A;  1O9S A;  3S8P A;  3DAL A;  4O6F A;  3VUZ A;  5AYF A;  2W5Y A;  4JDS A;  3S7F A;  1XQH A;  5JIN A;  5CPR B;  3M53 A;  5T0M A;  3DB5 A;  2G46 A;  4YPE A;  3F9Y A;  5KJM A;  4MI0 A;  4AU7 A;  3OPE A;  3TG5 A;  4YNP A;  4JLG A;  3MEK A;  3RQ4 A;  3IHX A;  3M56 A;  5KJN A;  3OS5 A;  5TEG A;  3RU0 A;  5HQ8 A;  3MO2 A;  1MVX A;  5JHN A;  2R3A A;  3KMJ A;  5TTF A;  3CBP A;  3M54 A;  3RJW A;  4J8O A;  3N71 A;  3MO5 A;  4BUP A;  4YPA A;  3FPD A;  2F69 A;  3QWW A;  3OXL A;  3OXF A;  3RIB A;  5ARF A;  5F59 A;  4WUY A;  4MI5 A;  1MT6 A;  3OXG A;  3M58 A;  4QEO A;  1H3I A;  3HNA A;  5JIY A;  3VV0 A;  3EP0 A;  3MO0 A;  4Z4P A;  4J7F A;  3S7B A;  2IGQ A;  2RFI A;  3KMT A;  5F6L A;  4QEP A;  5EX0 A;  3M57 A;  3OOI A;  3F9W A;  1MVH A;  5LSX A;  5KJK A;  5CCM A;  4NVQ A;  4YNM A;  5T5G A;  4I51 A;  3QWV A;  5EG2 A;  3SWC A;  1PEG A;  2JV0 A;  5ARG A;  5T0K A;  3SW9 A;  3CBO A;  4J7I A;  5LSZ A;  3K5K A;  4YPU A;  1N6A A;  4YND A;  5KJL A;  3KMA A;  2QPW A;  4C1Q A;  4IJ8 A;  3TG4 A;  3PDN A;  1MUF A;  3F9Z A;  5HI7 A;  4QEN A;  4J83 A;  3QWP A;  3F9X A;  4E47 A;  5JJ0 A;  4IJD A;  5F5E A;  4RZ0 A;  3M55 A;  5TH7 A;  4NJ5 A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...