3HNAA

Crystal structure of catalytic domain of human euchromatic histone methyltransferase 1 in complex with sah and mono-methylated h3k9 peptide
Total Genus 75
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
75
sequence length
287
structure length
280
Chain Sequence
GSNSQVWSALQMSKALPSPVERIVSRDIARGYERIPIPCVNAVDSEPCPSNYKYVSQNCVTSPMNIDRNITHLQYCVCIDDCSSSNCMCGQLSMRCWYDKDGRLLPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLDNKDGEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIKGKLFSCRCGSPKCRHS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural biology of human H3K9 methyltransferases
pubmed doi rcsb
source organism Homo sapiens
molecule tags Hydrolase/hydrolase regulator
molecule keywords Histone-lysine N-methyltransferase, H3 lysine-9 specific 5
total genus 75
structure length 280
sequence length 287
chains with identical sequence B
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2009-05-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF05033 Pre-SET Pre-SET motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 3hnaA00
1MVHA 2G46A 4NJ5A 1N6AA 4QEOA 4MI5A 1ZKKA 5T0KA 3TG4A 1MUFA 3TG5A 3K5KA 4QENA 3SW9A 4FMUA 4E47A 5TTFA 2F69A 4YNDA 1MT6A 1N6CA 5KJNA 4JLGA 1MVXA 3M55A 1PEGA 3SWCA 4IJDA 2BQZA 3OXGA 3RQ4A 3RU0A 5JJ0A 5T5GA 2RFIA 5F5EA 1O9SA 3OS5A 4YNPA 2W5ZA 4YPAA 5AYFA 5KJMA 3VV0A 5HI7A 3IHXA 1H3IA 3S7BA 3S7DA 4MI0A 3KMTA 3M58A 1ML9A 1N3JA 5KJKA 5F59A 3MO0A 4YPUA 4C1QA 5CPRB 4J7FA 3DB5A 2JV0A 5ARFA 3RJWA 2O8JA 3HNAA 4Z4PA 3MO2A 4NVQA 4IJ8A 3RIBA 5LSZA 3QWVA 5JHNA 5KJLA 3M54A 4YNMA 3F9WA 3N71A 4LDGA 3MO5A 3MEKA 4QEPA 4J7IA 5EX0A 5HQ8A 3F9ZA 5EG2A 5JINA 3M57A 3CBPA 4YPEA 5ARGA 5JIYA 5TEGA 4JDSA 4O30A 3OPEA 4I51A 3S8PA 3CBOA 5CCLA 3OOIA 3QWWA 5LSXA 4WUYA 3S7FA 5F6KC 3KMJA 3KMAA 3FPDA 2IGQA 3QWPA 4O6FA 4H12A 3M56A 3DALA 4RZ0A 3CBMA 3PDNA 5F6LA 5CCMA 3F9YA 3EP0A 2W5YA 3S7JA 5T0MA 3RAYA 1XQHA 2QPWA 2R3AA 3BO5A 4J8OA 4BUPA 3F9XA 4J83A 3OXLA 5EX3A 3OXFA 3M53A 4AU7A 3M59A 3VUZA 3M5AA 5TH7A
chains in the Genus database with same CATH superfamily
1MVHA 2G46A 4NJ5A 1N6AA 4QEOA 4MI5A 1ZKKA 5T0KA 3TG4A 1MUFA 3TG5A 3K5KA 4QENA 3SW9A 4FMUA 4E47A 5TTFA 2F69A 4YNDA 1MT6A 1N6CA 5KJNA 4JLGA 1MVXA 3M55A 1PEGA 3SWCA 4IJDA 2BQZA 3OXGA 3RQ4A 3RU0A 5JJ0A 5T5GA 2RFIA 5F5EA 1O9SA 3OS5A 4YNPA 2W5ZA 4YPAA 5AYFA 5KJMA 3VV0A 5HI7A 3IHXA 1H3IA 3S7BA 3S7DA 4MI0A 3KMTA 3M58A 1ML9A 1N3JA 5KJKA 5F59A 3MO0A 4YPUA 4C1QA 5CPRB 4J7FA 3DB5A 2JV0A 5ARFA 3RJWA 2O8JA 3HNAA 4Z4PA 3MO2A 4NVQA 4IJ8A 3RIBA 5LSZA 3QWVA 5JHNA 5KJLA 3M54A 4YNMA 3F9WA 3N71A 4LDGA 3MO5A 3MEKA 4QEPA 4J7IA 5EX0A 5HQ8A 3F9ZA 5EG2A 5JINA 3M57A 3CBPA 4YPEA 5ARGA 5JIYA 5TEGA 4JDSA 4O30A 3OPEA 4I51A 3S8PA 3CBOA 5CCLA 3OOIA 3QWWA 5LSXA 4WUYA 3S7FA 5F6KC 3KMJA 3KMAA 3FPDA 2IGQA 3QWPA 4O6FA 4H12A 3M56A 3DALA 4RZ0A 3CBMA 3PDNA 5F6LA 5CCMA 3F9YA 3EP0A 2W5YA 3S7JA 5T0MA 3RAYA 1XQHA 2QPWA 2R3AA 3BO5A 4J8OA 4BUPA 3F9XA 4J83A 3OXLA 5EX3A 3OXFA 3M53A 4AU7A 3M59A 3VUZA 3M5AA 5TH7A
chains in the Genus database with same CATH topology
1MVHA 2G46A 4NJ5A 1N6AA 4QEOA 4MI5A 1ZKKA 5T0KA 3TG4A 1MUFA 3TG5A 3K5KA 4QENA 3SW9A 4FMUA 4E47A 5TTFA 2F69A 4YNDA 1MT6A 1N6CA 5KJNA 4JLGA 1MVXA 3M55A 1PEGA 3SWCA 4IJDA 2BQZA 3OXGA 3RQ4A 3RU0A 5JJ0A 5T5GA 2RFIA 5F5EA 1O9SA 3OS5A 4YNPA 2W5ZA 4YPAA 5AYFA 5KJMA 3VV0A 5HI7A 3IHXA 1H3IA 3S7BA 3S7DA 4MI0A 3KMTA 3M58A 1ML9A 1N3JA 5KJKA 5F59A 3MO0A 4YPUA 4C1QA 5CPRB 4J7FA 3DB5A 2JV0A 5ARFA 3RJWA 2O8JA 3HNAA 4Z4PA 3MO2A 4NVQA 4IJ8A 3RIBA 5LSZA 3QWVA 5JHNA 5KJLA 3M54A 4YNMA 3F9WA 3N71A 4LDGA 3MO5A 3MEKA 4QEPA 4J7IA 5EX0A 5HQ8A 3F9ZA 5EG2A 5JINA 3M57A 3CBPA 4YPEA 5ARGA 5JIYA 5TEGA 4JDSA 4O30A 3OPEA 4I51A 3S8PA 3CBOA 5CCLA 3OOIA 3QWWA 5LSXA 4WUYA 3S7FA 5F6KC 3KMJA 3KMAA 3FPDA 2IGQA 3QWPA 4O6FA 4H12A 3M56A 3DALA 4RZ0A 3CBMA 3PDNA 5F6LA 5CCMA 3F9YA 3EP0A 2W5YA 3S7JA 5T0MA 3RAYA 1XQHA 2QPWA 2R3AA 3BO5A 4J8OA 4BUPA 3F9XA 4J83A 3OXLA 5EX3A 3OXFA 3M53A 4AU7A 3M59A 3VUZA 3M5AA 5TH7A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1MVH A;  2G46 A;  4NJ5 A;  1N6A A;  4QEO A;  4MI5 A;  1ZKK A;  5T0K A;  3TG4 A;  1MUF A;  3TG5 A;  3K5K A;  4QEN A;  3SW9 A;  4FMU A;  4E47 A;  5TTF A;  2F69 A;  4YND A;  1MT6 A;  1N6C A;  5KJN A;  4JLG A;  1MVX A;  3M55 A;  1PEG A;  3SWC A;  4IJD A;  2BQZ A;  3OXG A;  3RQ4 A;  3RU0 A;  5JJ0 A;  5T5G A;  2RFI A;  5F5E A;  1O9S A;  3OS5 A;  4YNP A;  2W5Z A;  4YPA A;  5AYF A;  5KJM A;  3VV0 A;  5HI7 A;  3IHX A;  1H3I A;  3S7B A;  3S7D A;  4MI0 A;  3KMT A;  3M58 A;  1ML9 A;  1N3J A;  5KJK A;  5F59 A;  3MO0 A;  4YPU A;  4C1Q A;  5CPR B;  4J7F A;  3DB5 A;  2JV0 A;  5ARF A;  3RJW A;  2O8J A;  3HNA A;  4Z4P A;  3MO2 A;  4NVQ A;  4IJ8 A;  3RIB A;  5LSZ A;  3QWV A;  5JHN A;  5KJL A;  3M54 A;  4YNM A;  3F9W A;  3N71 A;  4LDG A;  3MO5 A;  3MEK A;  4QEP A;  4J7I A;  5EX0 A;  5HQ8 A;  3F9Z A;  5EG2 A;  5JIN A;  3M57 A;  3CBP A;  4YPE A;  5ARG A;  5JIY A;  5TEG A;  4JDS A;  4O30 A;  3OPE A;  4I51 A;  3S8P A;  3CBO A;  5CCL A;  3OOI A;  3QWW A;  5LSX A;  4WUY A;  3S7F A;  5F6K C;  3KMJ A;  3KMA A;  3FPD A;  2IGQ A;  3QWP A;  4O6F A;  4H12 A;  3M56 A;  3DAL A;  4RZ0 A;  3CBM A;  3PDN A;  5F6L A;  5CCM A;  3F9Y A;  3EP0 A;  2W5Y A;  3S7J A;  5T0M A;  3RAY A;  1XQH A;  2QPW A;  2R3A A;  3BO5 A;  4J8O A;  4BUP A;  3F9X A;  4J83 A;  3OXL A;  5EX3 A;  3OXF A;  3M53 A;  4AU7 A;  3M59 A;  3VUZ A;  3M5A A;  5TH7 A; 
#chains in the Genus database with same CATH topology
 1MVH A;  2G46 A;  4NJ5 A;  1N6A A;  4QEO A;  4MI5 A;  1ZKK A;  5T0K A;  3TG4 A;  1MUF A;  3TG5 A;  3K5K A;  4QEN A;  3SW9 A;  4FMU A;  4E47 A;  5TTF A;  2F69 A;  4YND A;  1MT6 A;  1N6C A;  5KJN A;  4JLG A;  1MVX A;  3M55 A;  1PEG A;  3SWC A;  4IJD A;  2BQZ A;  3OXG A;  3RQ4 A;  3RU0 A;  5JJ0 A;  5T5G A;  2RFI A;  5F5E A;  1O9S A;  3OS5 A;  4YNP A;  2W5Z A;  4YPA A;  5AYF A;  5KJM A;  3VV0 A;  5HI7 A;  3IHX A;  1H3I A;  3S7B A;  3S7D A;  4MI0 A;  3KMT A;  3M58 A;  1ML9 A;  1N3J A;  5KJK A;  5F59 A;  3MO0 A;  4YPU A;  4C1Q A;  5CPR B;  4J7F A;  3DB5 A;  2JV0 A;  5ARF A;  3RJW A;  2O8J A;  3HNA A;  4Z4P A;  3MO2 A;  4NVQ A;  4IJ8 A;  3RIB A;  5LSZ A;  3QWV A;  5JHN A;  5KJL A;  3M54 A;  4YNM A;  3F9W A;  3N71 A;  4LDG A;  3MO5 A;  3MEK A;  4QEP A;  4J7I A;  5EX0 A;  5HQ8 A;  3F9Z A;  5EG2 A;  5JIN A;  3M57 A;  3CBP A;  4YPE A;  5ARG A;  5JIY A;  5TEG A;  4JDS A;  4O30 A;  3OPE A;  4I51 A;  3S8P A;  3CBO A;  5CCL A;  3OOI A;  3QWW A;  5LSX A;  4WUY A;  3S7F A;  5F6K C;  3KMJ A;  3KMA A;  3FPD A;  2IGQ A;  3QWP A;  4O6F A;  4H12 A;  3M56 A;  3DAL A;  4RZ0 A;  3CBM A;  3PDN A;  5F6L A;  5CCM A;  3F9Y A;  3EP0 A;  2W5Y A;  3S7J A;  5T0M A;  3RAY A;  1XQH A;  2QPW A;  2R3A A;  3BO5 A;  4J8O A;  4BUP A;  3F9X A;  4J83 A;  3OXL A;  5EX3 A;  3OXF A;  3M53 A;  4AU7 A;  3M59 A;  3VUZ A;  3M5A A;  5TH7 A; 
#chains in the Genus database with same CATH homology
 1MVH A;  2G46 A;  4NJ5 A;  1N6A A;  4QEO A;  4MI5 A;  1ZKK A;  5T0K A;  3TG4 A;  1MUF A;  3TG5 A;  3K5K A;  4QEN A;  3SW9 A;  4FMU A;  4E47 A;  5TTF A;  2F69 A;  4YND A;  1MT6 A;  1N6C A;  5KJN A;  4JLG A;  1MVX A;  3M55 A;  1PEG A;  3SWC A;  4IJD A;  2BQZ A;  3OXG A;  3RQ4 A;  3RU0 A;  5JJ0 A;  5T5G A;  2RFI A;  5F5E A;  1O9S A;  3OS5 A;  4YNP A;  2W5Z A;  4YPA A;  5AYF A;  5KJM A;  3VV0 A;  5HI7 A;  3IHX A;  1H3I A;  3S7B A;  3S7D A;  4MI0 A;  3KMT A;  3M58 A;  1ML9 A;  1N3J A;  5KJK A;  5F59 A;  3MO0 A;  4YPU A;  4C1Q A;  5CPR B;  4J7F A;  3DB5 A;  2JV0 A;  5ARF A;  3RJW A;  2O8J A;  3HNA A;  4Z4P A;  3MO2 A;  4NVQ A;  4IJ8 A;  3RIB A;  5LSZ A;  3QWV A;  5JHN A;  5KJL A;  3M54 A;  4YNM A;  3F9W A;  3N71 A;  4LDG A;  3MO5 A;  3MEK A;  4QEP A;  4J7I A;  5EX0 A;  5HQ8 A;  3F9Z A;  5EG2 A;  5JIN A;  3M57 A;  3CBP A;  4YPE A;  5ARG A;  5JIY A;  5TEG A;  4JDS A;  4O30 A;  3OPE A;  4I51 A;  3S8P A;  3CBO A;  5CCL A;  3OOI A;  3QWW A;  5LSX A;  4WUY A;  3S7F A;  5F6K C;  3KMJ A;  3KMA A;  3FPD A;  2IGQ A;  3QWP A;  4O6F A;  4H12 A;  3M56 A;  3DAL A;  4RZ0 A;  3CBM A;  3PDN A;  5F6L A;  5CCM A;  3F9Y A;  3EP0 A;  2W5Y A;  3S7J A;  5T0M A;  3RAY A;  1XQH A;  2QPW A;  2R3A A;  3BO5 A;  4J8O A;  4BUP A;  3F9X A;  4J83 A;  3OXL A;  5EX3 A;  3OXF A;  3M53 A;  4AU7 A;  3M59 A;  3VUZ A;  3M5A A;  5TH7 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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