3HNAA

Crystal structure of catalytic domain of human euchromatic histone methyltransferase 1 in complex with sah and mono-methylated h3k9 peptide
Total Genus 75
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
75
sequence length
287
structure length
280
Chain Sequence
GSNSQVWSALQMSKALPSPVERIVSRDIARGYERIPIPCVNAVDSEPCPSNYKYVSQNCVTSPMNIDRNITHLQYCVCIDDCSSSNCMCGQLSMRCWYDKDGRLLPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLDNKDGEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIKGKLFSCRCGSPKCRHS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Histone-lysine N-methyltransferase, H3 lysine-9 specific 5
publication title Structural biology of human H3K9 methyltransferases
pubmed doi rcsb
source organism Homo sapiens
molecule tags Hydrolase/hydrolase regulator
total genus 75
structure length 280
sequence length 287
chains with identical sequence B
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2009-05-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF05033 Pre-SET Pre-SET motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 3hnaA00
5JIYA 4AU7A 4YPUA 3M57A 4RZ0A 3EP0A 4J7IA 5F59A 3PDNA 3QWPA 3QWWA 3CBOA 5TTFA 3S7BA 3OXLA 4JLGA 4JDSA 5HI7A 3RJWA 4FMUA 4BUPA 4WUYA 3F9YA 3CBMA 3SWCA 1ML9A 3RU0A 4J8OA 4IJDA 3MO5A 1H3IA 3F9ZA 3N71A 5T0MA 5ARFA 3RAYA 3M56A 2W5ZA 5KJLA 4E47A 5CPRB 5F6KC 3S7FA 3HNAA 5EX0A 1N3JA 3M54A 4QENA 3M5AA 4YPAA 4LDGA 2W5YA 5HQ8A 5JJ0A 1MVXA 3M55A 3S7JA 2G46A 1MVHA 3MO2A 5CCLA 3BO5A 3OPEA 5KJMA 1N6AA 2BQZA 4QEOA 4O30A 2R3AA 4MI0A 5JHNA 1PEGA 4J83A 5TH7A 3RQ4A 5LSXA 2F69A 4H12A 5T0KA 1N6CA 5ARGA 5KJNA 5F5EA 3MO0A 5EX3A 4QEPA 2RFIA 2IGQA 3TG5A 3S8PA 4YPEA 4IJ8A 5EG2A 5F6LA 4J7FA 5T5GA 2JV0A 1O9SA 3FPDA 4C1QA 5AYFA 5LSZA 4YNDA 3VUZA 3TG4A 3KMJA 3MEKA 3K5KA 4NJ5A 3IHXA 4YNMA 4O6FA 3F9WA 3KMAA 3M59A 4I51A 3SW9A 3M58A 1MUFA 3OXFA 3QWVA 3RIBA 3DB5A 2QPWA 3OXGA 5CCMA 5JINA 3CBPA 4Z4PA 3OOIA 3S7DA 1XQHA 3DALA 1MT6A 3KMTA 4NVQA 3VV0A 3M53A 1ZKKA 2O8JA 3F9XA 3OS5A 5KJKA 4MI5A 5TEGA 4YNPA
chains in the Genus database with same CATH superfamily
5JIYA 4AU7A 4YPUA 3M57A 4RZ0A 3EP0A 4J7IA 5F59A 3PDNA 3QWPA 3QWWA 3CBOA 5TTFA 3S7BA 3OXLA 4JLGA 4JDSA 5HI7A 3RJWA 4FMUA 4BUPA 4WUYA 3F9YA 3CBMA 3SWCA 1ML9A 3RU0A 4J8OA 4IJDA 3MO5A 1H3IA 3F9ZA 3N71A 5T0MA 5ARFA 3RAYA 3M56A 2W5ZA 5KJLA 4E47A 5CPRB 5F6KC 3S7FA 3HNAA 5EX0A 1N3JA 3M54A 4QENA 3M5AA 4YPAA 4LDGA 2W5YA 5HQ8A 5JJ0A 1MVXA 3M55A 3S7JA 2G46A 1MVHA 3MO2A 5CCLA 3BO5A 3OPEA 5KJMA 1N6AA 2BQZA 4QEOA 4O30A 2R3AA 4MI0A 5JHNA 1PEGA 4J83A 5TH7A 3RQ4A 5LSXA 2F69A 4H12A 5T0KA 1N6CA 5ARGA 5KJNA 5F5EA 3MO0A 5EX3A 4QEPA 2RFIA 2IGQA 3TG5A 3S8PA 4YPEA 4IJ8A 5EG2A 5F6LA 4J7FA 5T5GA 2JV0A 1O9SA 3FPDA 4C1QA 5AYFA 5LSZA 4YNDA 3VUZA 3TG4A 3KMJA 3MEKA 3K5KA 4NJ5A 3IHXA 4YNMA 4O6FA 3F9WA 3KMAA 3M59A 4I51A 3SW9A 3M58A 1MUFA 3OXFA 3QWVA 3RIBA 3DB5A 2QPWA 3OXGA 5CCMA 5JINA 3CBPA 4Z4PA 3OOIA 3S7DA 1XQHA 3DALA 1MT6A 3KMTA 4NVQA 3VV0A 3M53A 1ZKKA 2O8JA 3F9XA 3OS5A 5KJKA 4MI5A 5TEGA 4YNPA
chains in the Genus database with same CATH topology
5JIYA 4AU7A 4YPUA 3M57A 4RZ0A 3EP0A 4J7IA 5F59A 3PDNA 3QWPA 3QWWA 3CBOA 5TTFA 3S7BA 3OXLA 4JLGA 4JDSA 5HI7A 3RJWA 4FMUA 4BUPA 4WUYA 3F9YA 3CBMA 3SWCA 1ML9A 3RU0A 4J8OA 4IJDA 3MO5A 1H3IA 3F9ZA 3N71A 5T0MA 5ARFA 3RAYA 3M56A 2W5ZA 5KJLA 4E47A 5CPRB 5F6KC 3S7FA 3HNAA 5EX0A 1N3JA 3M54A 4QENA 3M5AA 4YPAA 4LDGA 2W5YA 5HQ8A 5JJ0A 1MVXA 3M55A 3S7JA 2G46A 1MVHA 3MO2A 5CCLA 3BO5A 3OPEA 5KJMA 1N6AA 2BQZA 4QEOA 4O30A 2R3AA 4MI0A 5JHNA 1PEGA 4J83A 5TH7A 3RQ4A 5LSXA 2F69A 4H12A 5T0KA 1N6CA 5ARGA 5KJNA 5F5EA 3MO0A 5EX3A 4QEPA 2RFIA 2IGQA 3TG5A 3S8PA 4YPEA 4IJ8A 5EG2A 5F6LA 4J7FA 5T5GA 2JV0A 1O9SA 3FPDA 4C1QA 5AYFA 5LSZA 4YNDA 3VUZA 3TG4A 3KMJA 3MEKA 3K5KA 4NJ5A 3IHXA 4YNMA 4O6FA 3F9WA 3KMAA 3M59A 4I51A 3SW9A 3M58A 1MUFA 3OXFA 3QWVA 3RIBA 3DB5A 2QPWA 3OXGA 5CCMA 5JINA 3CBPA 4Z4PA 3OOIA 3S7DA 1XQHA 3DALA 1MT6A 3KMTA 4NVQA 3VV0A 3M53A 1ZKKA 2O8JA 3F9XA 3OS5A 5KJKA 4MI5A 5TEGA 4YNPA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5JIY A;  4AU7 A;  4YPU A;  3M57 A;  4RZ0 A;  3EP0 A;  4J7I A;  5F59 A;  3PDN A;  3QWP A;  3QWW A;  3CBO A;  5TTF A;  3S7B A;  3OXL A;  4JLG A;  4JDS A;  5HI7 A;  3RJW A;  4FMU A;  4BUP A;  4WUY A;  3F9Y A;  3CBM A;  3SWC A;  1ML9 A;  3RU0 A;  4J8O A;  4IJD A;  3MO5 A;  1H3I A;  3F9Z A;  3N71 A;  5T0M A;  5ARF A;  3RAY A;  3M56 A;  2W5Z A;  5KJL A;  4E47 A;  5CPR B;  5F6K C;  3S7F A;  3HNA A;  5EX0 A;  1N3J A;  3M54 A;  4QEN A;  3M5A A;  4YPA A;  4LDG A;  2W5Y A;  5HQ8 A;  5JJ0 A;  1MVX A;  3M55 A;  3S7J A;  2G46 A;  1MVH A;  3MO2 A;  5CCL A;  3BO5 A;  3OPE A;  5KJM A;  1N6A A;  2BQZ A;  4QEO A;  4O30 A;  2R3A A;  4MI0 A;  5JHN A;  1PEG A;  4J83 A;  5TH7 A;  3RQ4 A;  5LSX A;  2F69 A;  4H12 A;  5T0K A;  1N6C A;  5ARG A;  5KJN A;  5F5E A;  3MO0 A;  5EX3 A;  4QEP A;  2RFI A;  2IGQ A;  3TG5 A;  3S8P A;  4YPE A;  4IJ8 A;  5EG2 A;  5F6L A;  4J7F A;  5T5G A;  2JV0 A;  1O9S A;  3FPD A;  4C1Q A;  5AYF A;  5LSZ A;  4YND A;  3VUZ A;  3TG4 A;  3KMJ A;  3MEK A;  3K5K A;  4NJ5 A;  3IHX A;  4YNM A;  4O6F A;  3F9W A;  3KMA A;  3M59 A;  4I51 A;  3SW9 A;  3M58 A;  1MUF A;  3OXF A;  3QWV A;  3RIB A;  3DB5 A;  2QPW A;  3OXG A;  5CCM A;  5JIN A;  3CBP A;  4Z4P A;  3OOI A;  3S7D A;  1XQH A;  3DAL A;  1MT6 A;  3KMT A;  4NVQ A;  3VV0 A;  3M53 A;  1ZKK A;  2O8J A;  3F9X A;  3OS5 A;  5KJK A;  4MI5 A;  5TEG A;  4YNP A; 
#chains in the Genus database with same CATH topology
 5JIY A;  4AU7 A;  4YPU A;  3M57 A;  4RZ0 A;  3EP0 A;  4J7I A;  5F59 A;  3PDN A;  3QWP A;  3QWW A;  3CBO A;  5TTF A;  3S7B A;  3OXL A;  4JLG A;  4JDS A;  5HI7 A;  3RJW A;  4FMU A;  4BUP A;  4WUY A;  3F9Y A;  3CBM A;  3SWC A;  1ML9 A;  3RU0 A;  4J8O A;  4IJD A;  3MO5 A;  1H3I A;  3F9Z A;  3N71 A;  5T0M A;  5ARF A;  3RAY A;  3M56 A;  2W5Z A;  5KJL A;  4E47 A;  5CPR B;  5F6K C;  3S7F A;  3HNA A;  5EX0 A;  1N3J A;  3M54 A;  4QEN A;  3M5A A;  4YPA A;  4LDG A;  2W5Y A;  5HQ8 A;  5JJ0 A;  1MVX A;  3M55 A;  3S7J A;  2G46 A;  1MVH A;  3MO2 A;  5CCL A;  3BO5 A;  3OPE A;  5KJM A;  1N6A A;  2BQZ A;  4QEO A;  4O30 A;  2R3A A;  4MI0 A;  5JHN A;  1PEG A;  4J83 A;  5TH7 A;  3RQ4 A;  5LSX A;  2F69 A;  4H12 A;  5T0K A;  1N6C A;  5ARG A;  5KJN A;  5F5E A;  3MO0 A;  5EX3 A;  4QEP A;  2RFI A;  2IGQ A;  3TG5 A;  3S8P A;  4YPE A;  4IJ8 A;  5EG2 A;  5F6L A;  4J7F A;  5T5G A;  2JV0 A;  1O9S A;  3FPD A;  4C1Q A;  5AYF A;  5LSZ A;  4YND A;  3VUZ A;  3TG4 A;  3KMJ A;  3MEK A;  3K5K A;  4NJ5 A;  3IHX A;  4YNM A;  4O6F A;  3F9W A;  3KMA A;  3M59 A;  4I51 A;  3SW9 A;  3M58 A;  1MUF A;  3OXF A;  3QWV A;  3RIB A;  3DB5 A;  2QPW A;  3OXG A;  5CCM A;  5JIN A;  3CBP A;  4Z4P A;  3OOI A;  3S7D A;  1XQH A;  3DAL A;  1MT6 A;  3KMT A;  4NVQ A;  3VV0 A;  3M53 A;  1ZKK A;  2O8J A;  3F9X A;  3OS5 A;  5KJK A;  4MI5 A;  5TEG A;  4YNP A; 
#chains in the Genus database with same CATH homology
 5JIY A;  4AU7 A;  4YPU A;  3M57 A;  4RZ0 A;  3EP0 A;  4J7I A;  5F59 A;  3PDN A;  3QWP A;  3QWW A;  3CBO A;  5TTF A;  3S7B A;  3OXL A;  4JLG A;  4JDS A;  5HI7 A;  3RJW A;  4FMU A;  4BUP A;  4WUY A;  3F9Y A;  3CBM A;  3SWC A;  1ML9 A;  3RU0 A;  4J8O A;  4IJD A;  3MO5 A;  1H3I A;  3F9Z A;  3N71 A;  5T0M A;  5ARF A;  3RAY A;  3M56 A;  2W5Z A;  5KJL A;  4E47 A;  5CPR B;  5F6K C;  3S7F A;  3HNA A;  5EX0 A;  1N3J A;  3M54 A;  4QEN A;  3M5A A;  4YPA A;  4LDG A;  2W5Y A;  5HQ8 A;  5JJ0 A;  1MVX A;  3M55 A;  3S7J A;  2G46 A;  1MVH A;  3MO2 A;  5CCL A;  3BO5 A;  3OPE A;  5KJM A;  1N6A A;  2BQZ A;  4QEO A;  4O30 A;  2R3A A;  4MI0 A;  5JHN A;  1PEG A;  4J83 A;  5TH7 A;  3RQ4 A;  5LSX A;  2F69 A;  4H12 A;  5T0K A;  1N6C A;  5ARG A;  5KJN A;  5F5E A;  3MO0 A;  5EX3 A;  4QEP A;  2RFI A;  2IGQ A;  3TG5 A;  3S8P A;  4YPE A;  4IJ8 A;  5EG2 A;  5F6L A;  4J7F A;  5T5G A;  2JV0 A;  1O9S A;  3FPD A;  4C1Q A;  5AYF A;  5LSZ A;  4YND A;  3VUZ A;  3TG4 A;  3KMJ A;  3MEK A;  3K5K A;  4NJ5 A;  3IHX A;  4YNM A;  4O6F A;  3F9W A;  3KMA A;  3M59 A;  4I51 A;  3SW9 A;  3M58 A;  1MUF A;  3OXF A;  3QWV A;  3RIB A;  3DB5 A;  2QPW A;  3OXG A;  5CCM A;  5JIN A;  3CBP A;  4Z4P A;  3OOI A;  3S7D A;  1XQH A;  3DAL A;  1MT6 A;  3KMT A;  4NVQ A;  3VV0 A;  3M53 A;  1ZKK A;  2O8J A;  3F9X A;  3OS5 A;  5KJK A;  4MI5 A;  5TEG A;  4YNP A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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