5JIYA

Structure of g9a set-domain with histone h3k9norleucine mutant peptide and bound s-adenosylmethionine
Total Genus 79
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
79
sequence length
273
structure length
273
Chain Sequence
IRTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title S-adenosyl methionine is necessary for inhibition of the methyltransferase G9a by the lysine 9 to methionine mutation on histone H3.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Transferase
molecule keywords Histone-lysine N-methyltransferase EHMT2
total genus 79
structure length 273
sequence length 273
chains with identical sequence B
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2016-04-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF05033 Pre-SET Pre-SET motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 5jiyA00
5CPRB 5EX3A 3OPEA 3BO5A 1N6AA 3RU0A 1O9SA 5ARGA 3HNAA 4LDGA 4J8OA 2IGQA 3SWCA 5KJLA 2F69A 3MO0A 2JV0A 2O8JA 3M55A 1N6CA 2R3AA 3OXGA 4IJDA 3CBOA 1ZKKA 3DB5A 3M57A 4O6FA 3DALA 3M54A 1MVXA 4JLGA 4YNPA 4YPEA 5LSXA 2QPWA 4QENA 5T5GA 1MUFA 5F59A 5F5EA 5T0MA 3RJWA 3KMAA 1XQHA 5KJKA 5JHNA 3M58A 4NVQA 4BUPA 5HI7A 5CCMA 3CBMA 1PEGA 3QWWA 3MEKA 3OXFA 3TG4A 5EX0A 3FPDA 4FMUA 3CBPA 3VUZA 3QWVA 3MO5A 4Z4PA 4RZ0A 2W5YA 4MI0A 4H12A 4QEOA 4IJ8A 3S7DA 3F9XA 4QEPA 4O30A 5F6KC 3RIBA 3MO2A 5TTFA 3RQ4A 4J7IA 5ARFA 5KJNA 3EP0A 5TEGA 4YPUA 3F9WA 1ML9A 5TH7A 3KMJA 4YNMA 3QWPA 3K5KA 3S8PA 3OS5A 3M53A 4E47A 4MI5A 3S7FA 4AU7A 1MVHA 4J83A 3M59A 3F9ZA 5CCLA 3IHXA 3M56A 3VV0A 1N3JA 2G46A 3M5AA 5HQ8A 4I51A 5AYFA 2BQZA 4C1QA 5JINA 3PDNA 1MT6A 5F6LA 3OXLA 4J7FA 5EG2A 1H3IA 2W5ZA 3KMTA 3TG5A 5JIYA 4YNDA 3N71A 4JDSA 4NJ5A 5LSZA 2RFIA 5JJ0A 4YPAA 3RAYA 3SW9A 3F9YA 5KJMA 3S7BA 5T0KA 3S7JA 3OOIA 4WUYA
chains in the Genus database with same CATH superfamily
5CPRB 5EX3A 3OPEA 3BO5A 1N6AA 3RU0A 1O9SA 5ARGA 3HNAA 4LDGA 4J8OA 2IGQA 3SWCA 5KJLA 2F69A 3MO0A 2JV0A 2O8JA 3M55A 1N6CA 2R3AA 3OXGA 4IJDA 3CBOA 1ZKKA 3DB5A 3M57A 4O6FA 3DALA 3M54A 1MVXA 4JLGA 4YNPA 4YPEA 5LSXA 2QPWA 4QENA 5T5GA 1MUFA 5F59A 5F5EA 5T0MA 3RJWA 3KMAA 1XQHA 5KJKA 5JHNA 3M58A 4NVQA 4BUPA 5HI7A 5CCMA 3CBMA 1PEGA 3QWWA 3MEKA 3OXFA 3TG4A 5EX0A 3FPDA 4FMUA 3CBPA 3VUZA 3QWVA 3MO5A 4Z4PA 4RZ0A 2W5YA 4MI0A 4H12A 4QEOA 4IJ8A 3S7DA 3F9XA 4QEPA 4O30A 5F6KC 3RIBA 3MO2A 5TTFA 3RQ4A 4J7IA 5ARFA 5KJNA 3EP0A 5TEGA 4YPUA 3F9WA 1ML9A 5TH7A 3KMJA 4YNMA 3QWPA 3K5KA 3S8PA 3OS5A 3M53A 4E47A 4MI5A 3S7FA 4AU7A 1MVHA 4J83A 3M59A 3F9ZA 5CCLA 3IHXA 3M56A 3VV0A 1N3JA 2G46A 3M5AA 5HQ8A 4I51A 5AYFA 2BQZA 4C1QA 5JINA 3PDNA 1MT6A 5F6LA 3OXLA 4J7FA 5EG2A 1H3IA 2W5ZA 3KMTA 3TG5A 5JIYA 4YNDA 3N71A 4JDSA 4NJ5A 5LSZA 2RFIA 5JJ0A 4YPAA 3RAYA 3SW9A 3F9YA 5KJMA 3S7BA 5T0KA 3S7JA 3OOIA 4WUYA
chains in the Genus database with same CATH topology
5CPRB 5EX3A 3OPEA 3BO5A 1N6AA 3RU0A 1O9SA 5ARGA 3HNAA 4LDGA 4J8OA 2IGQA 3SWCA 5KJLA 2F69A 3MO0A 2JV0A 2O8JA 3M55A 1N6CA 2R3AA 3OXGA 4IJDA 3CBOA 1ZKKA 3DB5A 3M57A 4O6FA 3DALA 3M54A 1MVXA 4JLGA 4YNPA 4YPEA 5LSXA 2QPWA 4QENA 5T5GA 1MUFA 5F59A 5F5EA 5T0MA 3RJWA 3KMAA 1XQHA 5KJKA 5JHNA 3M58A 4NVQA 4BUPA 5HI7A 5CCMA 3CBMA 1PEGA 3QWWA 3MEKA 3OXFA 3TG4A 5EX0A 3FPDA 4FMUA 3CBPA 3VUZA 3QWVA 3MO5A 4Z4PA 4RZ0A 2W5YA 4MI0A 4H12A 4QEOA 4IJ8A 3S7DA 3F9XA 4QEPA 4O30A 5F6KC 3RIBA 3MO2A 5TTFA 3RQ4A 4J7IA 5ARFA 5KJNA 3EP0A 5TEGA 4YPUA 3F9WA 1ML9A 5TH7A 3KMJA 4YNMA 3QWPA 3K5KA 3S8PA 3OS5A 3M53A 4E47A 4MI5A 3S7FA 4AU7A 1MVHA 4J83A 3M59A 3F9ZA 5CCLA 3IHXA 3M56A 3VV0A 1N3JA 2G46A 3M5AA 5HQ8A 4I51A 5AYFA 2BQZA 4C1QA 5JINA 3PDNA 1MT6A 5F6LA 3OXLA 4J7FA 5EG2A 1H3IA 2W5ZA 3KMTA 3TG5A 5JIYA 4YNDA 3N71A 4JDSA 4NJ5A 5LSZA 2RFIA 5JJ0A 4YPAA 3RAYA 3SW9A 3F9YA 5KJMA 3S7BA 5T0KA 3S7JA 3OOIA 4WUYA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5CPR B;  5EX3 A;  3OPE A;  3BO5 A;  1N6A A;  3RU0 A;  1O9S A;  5ARG A;  3HNA A;  4LDG A;  4J8O A;  2IGQ A;  3SWC A;  5KJL A;  2F69 A;  3MO0 A;  2JV0 A;  2O8J A;  3M55 A;  1N6C A;  2R3A A;  3OXG A;  4IJD A;  3CBO A;  1ZKK A;  3DB5 A;  3M57 A;  4O6F A;  3DAL A;  3M54 A;  1MVX A;  4JLG A;  4YNP A;  4YPE A;  5LSX A;  2QPW A;  4QEN A;  5T5G A;  1MUF A;  5F59 A;  5F5E A;  5T0M A;  3RJW A;  3KMA A;  1XQH A;  5KJK A;  5JHN A;  3M58 A;  4NVQ A;  4BUP A;  5HI7 A;  5CCM A;  3CBM A;  1PEG A;  3QWW A;  3MEK A;  3OXF A;  3TG4 A;  5EX0 A;  3FPD A;  4FMU A;  3CBP A;  3VUZ A;  3QWV A;  3MO5 A;  4Z4P A;  4RZ0 A;  2W5Y A;  4MI0 A;  4H12 A;  4QEO A;  4IJ8 A;  3S7D A;  3F9X A;  4QEP A;  4O30 A;  5F6K C;  3RIB A;  3MO2 A;  5TTF A;  3RQ4 A;  4J7I A;  5ARF A;  5KJN A;  3EP0 A;  5TEG A;  4YPU A;  3F9W A;  1ML9 A;  5TH7 A;  3KMJ A;  4YNM A;  3QWP A;  3K5K A;  3S8P A;  3OS5 A;  3M53 A;  4E47 A;  4MI5 A;  3S7F A;  4AU7 A;  1MVH A;  4J83 A;  3M59 A;  3F9Z A;  5CCL A;  3IHX A;  3M56 A;  3VV0 A;  1N3J A;  2G46 A;  3M5A A;  5HQ8 A;  4I51 A;  5AYF A;  2BQZ A;  4C1Q A;  5JIN A;  3PDN A;  1MT6 A;  5F6L A;  3OXL A;  4J7F A;  5EG2 A;  1H3I A;  2W5Z A;  3KMT A;  3TG5 A;  5JIY A;  4YND A;  3N71 A;  4JDS A;  4NJ5 A;  5LSZ A;  2RFI A;  5JJ0 A;  4YPA A;  3RAY A;  3SW9 A;  3F9Y A;  5KJM A;  3S7B A;  5T0K A;  3S7J A;  3OOI A;  4WUY A; 
#chains in the Genus database with same CATH topology
 5CPR B;  5EX3 A;  3OPE A;  3BO5 A;  1N6A A;  3RU0 A;  1O9S A;  5ARG A;  3HNA A;  4LDG A;  4J8O A;  2IGQ A;  3SWC A;  5KJL A;  2F69 A;  3MO0 A;  2JV0 A;  2O8J A;  3M55 A;  1N6C A;  2R3A A;  3OXG A;  4IJD A;  3CBO A;  1ZKK A;  3DB5 A;  3M57 A;  4O6F A;  3DAL A;  3M54 A;  1MVX A;  4JLG A;  4YNP A;  4YPE A;  5LSX A;  2QPW A;  4QEN A;  5T5G A;  1MUF A;  5F59 A;  5F5E A;  5T0M A;  3RJW A;  3KMA A;  1XQH A;  5KJK A;  5JHN A;  3M58 A;  4NVQ A;  4BUP A;  5HI7 A;  5CCM A;  3CBM A;  1PEG A;  3QWW A;  3MEK A;  3OXF A;  3TG4 A;  5EX0 A;  3FPD A;  4FMU A;  3CBP A;  3VUZ A;  3QWV A;  3MO5 A;  4Z4P A;  4RZ0 A;  2W5Y A;  4MI0 A;  4H12 A;  4QEO A;  4IJ8 A;  3S7D A;  3F9X A;  4QEP A;  4O30 A;  5F6K C;  3RIB A;  3MO2 A;  5TTF A;  3RQ4 A;  4J7I A;  5ARF A;  5KJN A;  3EP0 A;  5TEG A;  4YPU A;  3F9W A;  1ML9 A;  5TH7 A;  3KMJ A;  4YNM A;  3QWP A;  3K5K A;  3S8P A;  3OS5 A;  3M53 A;  4E47 A;  4MI5 A;  3S7F A;  4AU7 A;  1MVH A;  4J83 A;  3M59 A;  3F9Z A;  5CCL A;  3IHX A;  3M56 A;  3VV0 A;  1N3J A;  2G46 A;  3M5A A;  5HQ8 A;  4I51 A;  5AYF A;  2BQZ A;  4C1Q A;  5JIN A;  3PDN A;  1MT6 A;  5F6L A;  3OXL A;  4J7F A;  5EG2 A;  1H3I A;  2W5Z A;  3KMT A;  3TG5 A;  5JIY A;  4YND A;  3N71 A;  4JDS A;  4NJ5 A;  5LSZ A;  2RFI A;  5JJ0 A;  4YPA A;  3RAY A;  3SW9 A;  3F9Y A;  5KJM A;  3S7B A;  5T0K A;  3S7J A;  3OOI A;  4WUY A; 
#chains in the Genus database with same CATH homology
 5CPR B;  5EX3 A;  3OPE A;  3BO5 A;  1N6A A;  3RU0 A;  1O9S A;  5ARG A;  3HNA A;  4LDG A;  4J8O A;  2IGQ A;  3SWC A;  5KJL A;  2F69 A;  3MO0 A;  2JV0 A;  2O8J A;  3M55 A;  1N6C A;  2R3A A;  3OXG A;  4IJD A;  3CBO A;  1ZKK A;  3DB5 A;  3M57 A;  4O6F A;  3DAL A;  3M54 A;  1MVX A;  4JLG A;  4YNP A;  4YPE A;  5LSX A;  2QPW A;  4QEN A;  5T5G A;  1MUF A;  5F59 A;  5F5E A;  5T0M A;  3RJW A;  3KMA A;  1XQH A;  5KJK A;  5JHN A;  3M58 A;  4NVQ A;  4BUP A;  5HI7 A;  5CCM A;  3CBM A;  1PEG A;  3QWW A;  3MEK A;  3OXF A;  3TG4 A;  5EX0 A;  3FPD A;  4FMU A;  3CBP A;  3VUZ A;  3QWV A;  3MO5 A;  4Z4P A;  4RZ0 A;  2W5Y A;  4MI0 A;  4H12 A;  4QEO A;  4IJ8 A;  3S7D A;  3F9X A;  4QEP A;  4O30 A;  5F6K C;  3RIB A;  3MO2 A;  5TTF A;  3RQ4 A;  4J7I A;  5ARF A;  5KJN A;  3EP0 A;  5TEG A;  4YPU A;  3F9W A;  1ML9 A;  5TH7 A;  3KMJ A;  4YNM A;  3QWP A;  3K5K A;  3S8P A;  3OS5 A;  3M53 A;  4E47 A;  4MI5 A;  3S7F A;  4AU7 A;  1MVH A;  4J83 A;  3M59 A;  3F9Z A;  5CCL A;  3IHX A;  3M56 A;  3VV0 A;  1N3J A;  2G46 A;  3M5A A;  5HQ8 A;  4I51 A;  5AYF A;  2BQZ A;  4C1Q A;  5JIN A;  3PDN A;  1MT6 A;  5F6L A;  3OXL A;  4J7F A;  5EG2 A;  1H3I A;  2W5Z A;  3KMT A;  3TG5 A;  5JIY A;  4YND A;  3N71 A;  4JDS A;  4NJ5 A;  5LSZ A;  2RFI A;  5JJ0 A;  4YPA A;  3RAY A;  3SW9 A;  3F9Y A;  5KJM A;  3S7B A;  5T0K A;  3S7J A;  3OOI A;  4WUY A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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