5JIYA

Structure of g9a set-domain with histone h3k9norleucine mutant peptide and bound s-adenosylmethionine
Total Genus 79
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
79
sequence length
273
structure length
273
Chain Sequence
IRTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Histone-lysine N-methyltransferase EHMT2
publication title S-adenosyl methionine is necessary for inhibition of the methyltransferase G9a by the lysine 9 to methionine mutation on histone H3.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Transferase
total genus 79
structure length 273
sequence length 273
chains with identical sequence B
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2016-04-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF05033 Pre-SET Pre-SET motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 5jiyA00
3CBPA 3BO5A 3S7JA 4IJDA 2IGQA 3MO5A 2G46A 3PDNA 3OOIA 5CPRB 4E47A 3TG4A 5JINA 4C1QA 4FMUA 1MUFA 5JIYA 5KJLA 3RQ4A 4RZ0A 3M59A 1MT6A 3CBMA 3N71A 3SW9A 5F6KC 3M57A 1H3IA 4QEPA 5CCMA 1MVXA 4QENA 3OPEA 5JHNA 3RU0A 3DB5A 5LSZA 1N3JA 3RJWA 5KJMA 5T5GA 3TG5A 1N6AA 2W5ZA 3OS5A 2W5YA 4H12A 2JV0A 5ARFA 3QWWA 3M58A 5F59A 5F6LA 2O8JA 1O9SA 3M54A 4JLGA 4IJ8A 5JJ0A 4NVQA 3F9XA 2F69A 2RFIA 3M55A 4J83A 4J8OA 3HNAA 3K5KA 5EG2A 4YPUA 1ZKKA 3S7FA 1N6CA 3VUZA 3SWCA 2QPWA 3OXFA 3RIBA 5KJNA 3KMTA 3OXGA 4LDGA 4MI0A 3RAYA 4BUPA 4JDSA 5T0KA 3M56A 3EP0A 5TEGA 5ARGA 3S7BA 3S8PA 3DALA 5AYFA 3QWPA 5HI7A 4MI5A 4O6FA 3MO2A 5T0MA 4NJ5A 3QWVA 3F9WA 5EX0A 4J7IA 3OXLA 4I51A 5LSXA 5KJKA 3MO0A 4YNPA 5EX3A 1ML9A 4WUYA 5CCLA 3MEKA 1MVHA 2R3AA 3IHXA 3KMJA 4AU7A 4QEOA 5HQ8A 4YPAA 4YNMA 3F9YA 2BQZA 3M5AA 3CBOA 3FPDA 4Z4PA 4J7FA 5TH7A 3M53A 4O30A 1PEGA 3S7DA 1XQHA 3VV0A 3KMAA 5F5EA 4YNDA 3F9ZA 5TTFA 4YPEA
chains in the Genus database with same CATH superfamily
3CBPA 3BO5A 3S7JA 4IJDA 2IGQA 3MO5A 2G46A 3PDNA 3OOIA 5CPRB 4E47A 3TG4A 5JINA 4C1QA 4FMUA 1MUFA 5JIYA 5KJLA 3RQ4A 4RZ0A 3M59A 1MT6A 3CBMA 3N71A 3SW9A 5F6KC 3M57A 1H3IA 4QEPA 5CCMA 1MVXA 4QENA 3OPEA 5JHNA 3RU0A 3DB5A 5LSZA 1N3JA 3RJWA 5KJMA 5T5GA 3TG5A 1N6AA 2W5ZA 3OS5A 2W5YA 4H12A 2JV0A 5ARFA 3QWWA 3M58A 5F59A 5F6LA 2O8JA 1O9SA 3M54A 4JLGA 4IJ8A 5JJ0A 4NVQA 3F9XA 2F69A 2RFIA 3M55A 4J83A 4J8OA 3HNAA 3K5KA 5EG2A 4YPUA 1ZKKA 3S7FA 1N6CA 3VUZA 3SWCA 2QPWA 3OXFA 3RIBA 5KJNA 3KMTA 3OXGA 4LDGA 4MI0A 3RAYA 4BUPA 4JDSA 5T0KA 3M56A 3EP0A 5TEGA 5ARGA 3S7BA 3S8PA 3DALA 5AYFA 3QWPA 5HI7A 4MI5A 4O6FA 3MO2A 5T0MA 4NJ5A 3QWVA 3F9WA 5EX0A 4J7IA 3OXLA 4I51A 5LSXA 5KJKA 3MO0A 4YNPA 5EX3A 1ML9A 4WUYA 5CCLA 3MEKA 1MVHA 2R3AA 3IHXA 3KMJA 4AU7A 4QEOA 5HQ8A 4YPAA 4YNMA 3F9YA 2BQZA 3M5AA 3CBOA 3FPDA 4Z4PA 4J7FA 5TH7A 3M53A 4O30A 1PEGA 3S7DA 1XQHA 3VV0A 3KMAA 5F5EA 4YNDA 3F9ZA 5TTFA 4YPEA
chains in the Genus database with same CATH topology
3CBPA 3BO5A 3S7JA 4IJDA 2IGQA 3MO5A 2G46A 3PDNA 3OOIA 5CPRB 4E47A 3TG4A 5JINA 4C1QA 4FMUA 1MUFA 5JIYA 5KJLA 3RQ4A 4RZ0A 3M59A 1MT6A 3CBMA 3N71A 3SW9A 5F6KC 3M57A 1H3IA 4QEPA 5CCMA 1MVXA 4QENA 3OPEA 5JHNA 3RU0A 3DB5A 5LSZA 1N3JA 3RJWA 5KJMA 5T5GA 3TG5A 1N6AA 2W5ZA 3OS5A 2W5YA 4H12A 2JV0A 5ARFA 3QWWA 3M58A 5F59A 5F6LA 2O8JA 1O9SA 3M54A 4JLGA 4IJ8A 5JJ0A 4NVQA 3F9XA 2F69A 2RFIA 3M55A 4J83A 4J8OA 3HNAA 3K5KA 5EG2A 4YPUA 1ZKKA 3S7FA 1N6CA 3VUZA 3SWCA 2QPWA 3OXFA 3RIBA 5KJNA 3KMTA 3OXGA 4LDGA 4MI0A 3RAYA 4BUPA 4JDSA 5T0KA 3M56A 3EP0A 5TEGA 5ARGA 3S7BA 3S8PA 3DALA 5AYFA 3QWPA 5HI7A 4MI5A 4O6FA 3MO2A 5T0MA 4NJ5A 3QWVA 3F9WA 5EX0A 4J7IA 3OXLA 4I51A 5LSXA 5KJKA 3MO0A 4YNPA 5EX3A 1ML9A 4WUYA 5CCLA 3MEKA 1MVHA 2R3AA 3IHXA 3KMJA 4AU7A 4QEOA 5HQ8A 4YPAA 4YNMA 3F9YA 2BQZA 3M5AA 3CBOA 3FPDA 4Z4PA 4J7FA 5TH7A 3M53A 4O30A 1PEGA 3S7DA 1XQHA 3VV0A 3KMAA 5F5EA 4YNDA 3F9ZA 5TTFA 4YPEA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3CBP A;  3BO5 A;  3S7J A;  4IJD A;  2IGQ A;  3MO5 A;  2G46 A;  3PDN A;  3OOI A;  5CPR B;  4E47 A;  3TG4 A;  5JIN A;  4C1Q A;  4FMU A;  1MUF A;  5JIY A;  5KJL A;  3RQ4 A;  4RZ0 A;  3M59 A;  1MT6 A;  3CBM A;  3N71 A;  3SW9 A;  5F6K C;  3M57 A;  1H3I A;  4QEP A;  5CCM A;  1MVX A;  4QEN A;  3OPE A;  5JHN A;  3RU0 A;  3DB5 A;  5LSZ A;  1N3J A;  3RJW A;  5KJM A;  5T5G A;  3TG5 A;  1N6A A;  2W5Z A;  3OS5 A;  2W5Y A;  4H12 A;  2JV0 A;  5ARF A;  3QWW A;  3M58 A;  5F59 A;  5F6L A;  2O8J A;  1O9S A;  3M54 A;  4JLG A;  4IJ8 A;  5JJ0 A;  4NVQ A;  3F9X A;  2F69 A;  2RFI A;  3M55 A;  4J83 A;  4J8O A;  3HNA A;  3K5K A;  5EG2 A;  4YPU A;  1ZKK A;  3S7F A;  1N6C A;  3VUZ A;  3SWC A;  2QPW A;  3OXF A;  3RIB A;  5KJN A;  3KMT A;  3OXG A;  4LDG A;  4MI0 A;  3RAY A;  4BUP A;  4JDS A;  5T0K A;  3M56 A;  3EP0 A;  5TEG A;  5ARG A;  3S7B A;  3S8P A;  3DAL A;  5AYF A;  3QWP A;  5HI7 A;  4MI5 A;  4O6F A;  3MO2 A;  5T0M A;  4NJ5 A;  3QWV A;  3F9W A;  5EX0 A;  4J7I A;  3OXL A;  4I51 A;  5LSX A;  5KJK A;  3MO0 A;  4YNP A;  5EX3 A;  1ML9 A;  4WUY A;  5CCL A;  3MEK A;  1MVH A;  2R3A A;  3IHX A;  3KMJ A;  4AU7 A;  4QEO A;  5HQ8 A;  4YPA A;  4YNM A;  3F9Y A;  2BQZ A;  3M5A A;  3CBO A;  3FPD A;  4Z4P A;  4J7F A;  5TH7 A;  3M53 A;  4O30 A;  1PEG A;  3S7D A;  1XQH A;  3VV0 A;  3KMA A;  5F5E A;  4YND A;  3F9Z A;  5TTF A;  4YPE A; 
#chains in the Genus database with same CATH topology
 3CBP A;  3BO5 A;  3S7J A;  4IJD A;  2IGQ A;  3MO5 A;  2G46 A;  3PDN A;  3OOI A;  5CPR B;  4E47 A;  3TG4 A;  5JIN A;  4C1Q A;  4FMU A;  1MUF A;  5JIY A;  5KJL A;  3RQ4 A;  4RZ0 A;  3M59 A;  1MT6 A;  3CBM A;  3N71 A;  3SW9 A;  5F6K C;  3M57 A;  1H3I A;  4QEP A;  5CCM A;  1MVX A;  4QEN A;  3OPE A;  5JHN A;  3RU0 A;  3DB5 A;  5LSZ A;  1N3J A;  3RJW A;  5KJM A;  5T5G A;  3TG5 A;  1N6A A;  2W5Z A;  3OS5 A;  2W5Y A;  4H12 A;  2JV0 A;  5ARF A;  3QWW A;  3M58 A;  5F59 A;  5F6L A;  2O8J A;  1O9S A;  3M54 A;  4JLG A;  4IJ8 A;  5JJ0 A;  4NVQ A;  3F9X A;  2F69 A;  2RFI A;  3M55 A;  4J83 A;  4J8O A;  3HNA A;  3K5K A;  5EG2 A;  4YPU A;  1ZKK A;  3S7F A;  1N6C A;  3VUZ A;  3SWC A;  2QPW A;  3OXF A;  3RIB A;  5KJN A;  3KMT A;  3OXG A;  4LDG A;  4MI0 A;  3RAY A;  4BUP A;  4JDS A;  5T0K A;  3M56 A;  3EP0 A;  5TEG A;  5ARG A;  3S7B A;  3S8P A;  3DAL A;  5AYF A;  3QWP A;  5HI7 A;  4MI5 A;  4O6F A;  3MO2 A;  5T0M A;  4NJ5 A;  3QWV A;  3F9W A;  5EX0 A;  4J7I A;  3OXL A;  4I51 A;  5LSX A;  5KJK A;  3MO0 A;  4YNP A;  5EX3 A;  1ML9 A;  4WUY A;  5CCL A;  3MEK A;  1MVH A;  2R3A A;  3IHX A;  3KMJ A;  4AU7 A;  4QEO A;  5HQ8 A;  4YPA A;  4YNM A;  3F9Y A;  2BQZ A;  3M5A A;  3CBO A;  3FPD A;  4Z4P A;  4J7F A;  5TH7 A;  3M53 A;  4O30 A;  1PEG A;  3S7D A;  1XQH A;  3VV0 A;  3KMA A;  5F5E A;  4YND A;  3F9Z A;  5TTF A;  4YPE A; 
#chains in the Genus database with same CATH homology
 3CBP A;  3BO5 A;  3S7J A;  4IJD A;  2IGQ A;  3MO5 A;  2G46 A;  3PDN A;  3OOI A;  5CPR B;  4E47 A;  3TG4 A;  5JIN A;  4C1Q A;  4FMU A;  1MUF A;  5JIY A;  5KJL A;  3RQ4 A;  4RZ0 A;  3M59 A;  1MT6 A;  3CBM A;  3N71 A;  3SW9 A;  5F6K C;  3M57 A;  1H3I A;  4QEP A;  5CCM A;  1MVX A;  4QEN A;  3OPE A;  5JHN A;  3RU0 A;  3DB5 A;  5LSZ A;  1N3J A;  3RJW A;  5KJM A;  5T5G A;  3TG5 A;  1N6A A;  2W5Z A;  3OS5 A;  2W5Y A;  4H12 A;  2JV0 A;  5ARF A;  3QWW A;  3M58 A;  5F59 A;  5F6L A;  2O8J A;  1O9S A;  3M54 A;  4JLG A;  4IJ8 A;  5JJ0 A;  4NVQ A;  3F9X A;  2F69 A;  2RFI A;  3M55 A;  4J83 A;  4J8O A;  3HNA A;  3K5K A;  5EG2 A;  4YPU A;  1ZKK A;  3S7F A;  1N6C A;  3VUZ A;  3SWC A;  2QPW A;  3OXF A;  3RIB A;  5KJN A;  3KMT A;  3OXG A;  4LDG A;  4MI0 A;  3RAY A;  4BUP A;  4JDS A;  5T0K A;  3M56 A;  3EP0 A;  5TEG A;  5ARG A;  3S7B A;  3S8P A;  3DAL A;  5AYF A;  3QWP A;  5HI7 A;  4MI5 A;  4O6F A;  3MO2 A;  5T0M A;  4NJ5 A;  3QWV A;  3F9W A;  5EX0 A;  4J7I A;  3OXL A;  4I51 A;  5LSX A;  5KJK A;  3MO0 A;  4YNP A;  5EX3 A;  1ML9 A;  4WUY A;  5CCL A;  3MEK A;  1MVH A;  2R3A A;  3IHX A;  3KMJ A;  4AU7 A;  4QEO A;  5HQ8 A;  4YPA A;  4YNM A;  3F9Y A;  2BQZ A;  3M5A A;  3CBO A;  3FPD A;  4Z4P A;  4J7F A;  5TH7 A;  3M53 A;  4O30 A;  1PEG A;  3S7D A;  1XQH A;  3VV0 A;  3KMA A;  5F5E A;  4YND A;  3F9Z A;  5TTF A;  4YPE A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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