5JIYA

Structure of g9a set-domain with histone h3k9norleucine mutant peptide and bound s-adenosylmethionine
Total Genus 79
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
79
sequence length
273
structure length
273
Chain Sequence
IRTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Transferase
molecule keywords Histone-lysine N-methyltransferase EHMT2
publication title S-adenosyl methionine is necessary for inhibition of the methyltransferase G9a by the lysine 9 to methionine mutation on histone H3.
pubmed doi rcsb
source organism Homo sapiens
total genus 79
structure length 273
sequence length 273
chains with identical sequence B
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2016-04-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF05033 Pre-SET Pre-SET motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 5jiyA00
5HQ8A 3OXGA 4BUPA 3QWPA 3M58A 3S7JA 3RU0A 2G46A 4LDGA 4Z4PA 4YNPA 1N6CA 5T0MA 5F59A 2BQZA 3S7DA 1PEGA 4QEOA 5HI7A 2QPWA 5JHNA 3F9WA 1MT6A 4AU7A 5JIYA 3KMTA 3OXLA 4J7FA 5JINA 3F9ZA 3EP0A 1N3JA 4YPEA 4MI0A 5ARFA 3MO2A 3KMAA 3HNAA 2RFIA 3KMJA 3M53A 4RZ0A 5F5EA 3CBMA 3OXFA 4J83A 3CBOA 1H3IA 3QWVA 5CCLA 2R3AA 3FPDA 5F6LA 3RAYA 4NVQA 2JV0A 4IJ8A 3M57A 5TTFA 4YNMA 5LSXA 1N6AA 3F9XA 5T0KA 3MO5A 3K5KA 3CBPA 4NJ5A 3VV0A 2W5ZA 5EG2A 5T5GA 3MO0A 4FMUA 4QENA 3S7BA 3DB5A 4O30A 3QWWA 3M59A 4WUYA 3SWCA 1MUFA 5KJLA 1XQHA 3PDNA 5EX3A 4J8OA 5KJNA 3DALA 4YPAA 4YPUA 5KJMA 3S8PA 3TG5A 3RQ4A 3OS5A 5EX0A 3OPEA 3M5AA 4J7IA 1O9SA 2F69A 3S7FA 4YNDA 3TG4A 4QEPA 4C1QA 3MEKA 4E47A 1MVHA 4JLGA 5ARGA 5JJ0A 5CPRB 3VUZA 5F6KC 3M55A 4O6FA 4H12A 3M56A 2IGQA 3RIBA 4MI5A 4JDSA 4I51A 3RJWA 5KJKA 3SW9A 4IJDA 1ZKKA 3IHXA 5LSZA 2W5YA 1MVXA 5TEGA 5TH7A 1ML9A 3F9YA 5AYFA 3M54A 3N71A 3BO5A 5CCMA 3OOIA 2O8JA
chains in the Genus database with same CATH superfamily
5HQ8A 3OXGA 4BUPA 3QWPA 3M58A 3S7JA 3RU0A 2G46A 4LDGA 4Z4PA 4YNPA 1N6CA 5T0MA 5F59A 2BQZA 3S7DA 1PEGA 4QEOA 5HI7A 2QPWA 5JHNA 3F9WA 1MT6A 4AU7A 5JIYA 3KMTA 3OXLA 4J7FA 5JINA 3F9ZA 3EP0A 1N3JA 4YPEA 4MI0A 5ARFA 3MO2A 3KMAA 3HNAA 2RFIA 3KMJA 3M53A 4RZ0A 5F5EA 3CBMA 3OXFA 4J83A 3CBOA 1H3IA 3QWVA 5CCLA 2R3AA 3FPDA 5F6LA 3RAYA 4NVQA 2JV0A 4IJ8A 3M57A 5TTFA 4YNMA 5LSXA 1N6AA 3F9XA 5T0KA 3MO5A 3K5KA 3CBPA 4NJ5A 3VV0A 2W5ZA 5EG2A 5T5GA 3MO0A 4FMUA 4QENA 3S7BA 3DB5A 4O30A 3QWWA 3M59A 4WUYA 3SWCA 1MUFA 5KJLA 1XQHA 3PDNA 5EX3A 4J8OA 5KJNA 3DALA 4YPAA 4YPUA 5KJMA 3S8PA 3TG5A 3RQ4A 3OS5A 5EX0A 3OPEA 3M5AA 4J7IA 1O9SA 2F69A 3S7FA 4YNDA 3TG4A 4QEPA 4C1QA 3MEKA 4E47A 1MVHA 4JLGA 5ARGA 5JJ0A 5CPRB 3VUZA 5F6KC 3M55A 4O6FA 4H12A 3M56A 2IGQA 3RIBA 4MI5A 4JDSA 4I51A 3RJWA 5KJKA 3SW9A 4IJDA 1ZKKA 3IHXA 5LSZA 2W5YA 1MVXA 5TEGA 5TH7A 1ML9A 3F9YA 5AYFA 3M54A 3N71A 3BO5A 5CCMA 3OOIA 2O8JA
chains in the Genus database with same CATH topology
5HQ8A 3OXGA 4BUPA 3QWPA 3M58A 3S7JA 3RU0A 2G46A 4LDGA 4Z4PA 4YNPA 1N6CA 5T0MA 5F59A 2BQZA 3S7DA 1PEGA 4QEOA 5HI7A 2QPWA 5JHNA 3F9WA 1MT6A 4AU7A 5JIYA 3KMTA 3OXLA 4J7FA 5JINA 3F9ZA 3EP0A 1N3JA 4YPEA 4MI0A 5ARFA 3MO2A 3KMAA 3HNAA 2RFIA 3KMJA 3M53A 4RZ0A 5F5EA 3CBMA 3OXFA 4J83A 3CBOA 1H3IA 3QWVA 5CCLA 2R3AA 3FPDA 5F6LA 3RAYA 4NVQA 2JV0A 4IJ8A 3M57A 5TTFA 4YNMA 5LSXA 1N6AA 3F9XA 5T0KA 3MO5A 3K5KA 3CBPA 4NJ5A 3VV0A 2W5ZA 5EG2A 5T5GA 3MO0A 4FMUA 4QENA 3S7BA 3DB5A 4O30A 3QWWA 3M59A 4WUYA 3SWCA 1MUFA 5KJLA 1XQHA 3PDNA 5EX3A 4J8OA 5KJNA 3DALA 4YPAA 4YPUA 5KJMA 3S8PA 3TG5A 3RQ4A 3OS5A 5EX0A 3OPEA 3M5AA 4J7IA 1O9SA 2F69A 3S7FA 4YNDA 3TG4A 4QEPA 4C1QA 3MEKA 4E47A 1MVHA 4JLGA 5ARGA 5JJ0A 5CPRB 3VUZA 5F6KC 3M55A 4O6FA 4H12A 3M56A 2IGQA 3RIBA 4MI5A 4JDSA 4I51A 3RJWA 5KJKA 3SW9A 4IJDA 1ZKKA 3IHXA 5LSZA 2W5YA 1MVXA 5TEGA 5TH7A 1ML9A 3F9YA 5AYFA 3M54A 3N71A 3BO5A 5CCMA 3OOIA 2O8JA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5HQ8 A;  3OXG A;  4BUP A;  3QWP A;  3M58 A;  3S7J A;  3RU0 A;  2G46 A;  4LDG A;  4Z4P A;  4YNP A;  1N6C A;  5T0M A;  5F59 A;  2BQZ A;  3S7D A;  1PEG A;  4QEO A;  5HI7 A;  2QPW A;  5JHN A;  3F9W A;  1MT6 A;  4AU7 A;  5JIY A;  3KMT A;  3OXL A;  4J7F A;  5JIN A;  3F9Z A;  3EP0 A;  1N3J A;  4YPE A;  4MI0 A;  5ARF A;  3MO2 A;  3KMA A;  3HNA A;  2RFI A;  3KMJ A;  3M53 A;  4RZ0 A;  5F5E A;  3CBM A;  3OXF A;  4J83 A;  3CBO A;  1H3I A;  3QWV A;  5CCL A;  2R3A A;  3FPD A;  5F6L A;  3RAY A;  4NVQ A;  2JV0 A;  4IJ8 A;  3M57 A;  5TTF A;  4YNM A;  5LSX A;  1N6A A;  3F9X A;  5T0K A;  3MO5 A;  3K5K A;  3CBP A;  4NJ5 A;  3VV0 A;  2W5Z A;  5EG2 A;  5T5G A;  3MO0 A;  4FMU A;  4QEN A;  3S7B A;  3DB5 A;  4O30 A;  3QWW A;  3M59 A;  4WUY A;  3SWC A;  1MUF A;  5KJL A;  1XQH A;  3PDN A;  5EX3 A;  4J8O A;  5KJN A;  3DAL A;  4YPA A;  4YPU A;  5KJM A;  3S8P A;  3TG5 A;  3RQ4 A;  3OS5 A;  5EX0 A;  3OPE A;  3M5A A;  4J7I A;  1O9S A;  2F69 A;  3S7F A;  4YND A;  3TG4 A;  4QEP A;  4C1Q A;  3MEK A;  4E47 A;  1MVH A;  4JLG A;  5ARG A;  5JJ0 A;  5CPR B;  3VUZ A;  5F6K C;  3M55 A;  4O6F A;  4H12 A;  3M56 A;  2IGQ A;  3RIB A;  4MI5 A;  4JDS A;  4I51 A;  3RJW A;  5KJK A;  3SW9 A;  4IJD A;  1ZKK A;  3IHX A;  5LSZ A;  2W5Y A;  1MVX A;  5TEG A;  5TH7 A;  1ML9 A;  3F9Y A;  5AYF A;  3M54 A;  3N71 A;  3BO5 A;  5CCM A;  3OOI A;  2O8J A; 
#chains in the Genus database with same CATH topology
 5HQ8 A;  3OXG A;  4BUP A;  3QWP A;  3M58 A;  3S7J A;  3RU0 A;  2G46 A;  4LDG A;  4Z4P A;  4YNP A;  1N6C A;  5T0M A;  5F59 A;  2BQZ A;  3S7D A;  1PEG A;  4QEO A;  5HI7 A;  2QPW A;  5JHN A;  3F9W A;  1MT6 A;  4AU7 A;  5JIY A;  3KMT A;  3OXL A;  4J7F A;  5JIN A;  3F9Z A;  3EP0 A;  1N3J A;  4YPE A;  4MI0 A;  5ARF A;  3MO2 A;  3KMA A;  3HNA A;  2RFI A;  3KMJ A;  3M53 A;  4RZ0 A;  5F5E A;  3CBM A;  3OXF A;  4J83 A;  3CBO A;  1H3I A;  3QWV A;  5CCL A;  2R3A A;  3FPD A;  5F6L A;  3RAY A;  4NVQ A;  2JV0 A;  4IJ8 A;  3M57 A;  5TTF A;  4YNM A;  5LSX A;  1N6A A;  3F9X A;  5T0K A;  3MO5 A;  3K5K A;  3CBP A;  4NJ5 A;  3VV0 A;  2W5Z A;  5EG2 A;  5T5G A;  3MO0 A;  4FMU A;  4QEN A;  3S7B A;  3DB5 A;  4O30 A;  3QWW A;  3M59 A;  4WUY A;  3SWC A;  1MUF A;  5KJL A;  1XQH A;  3PDN A;  5EX3 A;  4J8O A;  5KJN A;  3DAL A;  4YPA A;  4YPU A;  5KJM A;  3S8P A;  3TG5 A;  3RQ4 A;  3OS5 A;  5EX0 A;  3OPE A;  3M5A A;  4J7I A;  1O9S A;  2F69 A;  3S7F A;  4YND A;  3TG4 A;  4QEP A;  4C1Q A;  3MEK A;  4E47 A;  1MVH A;  4JLG A;  5ARG A;  5JJ0 A;  5CPR B;  3VUZ A;  5F6K C;  3M55 A;  4O6F A;  4H12 A;  3M56 A;  2IGQ A;  3RIB A;  4MI5 A;  4JDS A;  4I51 A;  3RJW A;  5KJK A;  3SW9 A;  4IJD A;  1ZKK A;  3IHX A;  5LSZ A;  2W5Y A;  1MVX A;  5TEG A;  5TH7 A;  1ML9 A;  3F9Y A;  5AYF A;  3M54 A;  3N71 A;  3BO5 A;  5CCM A;  3OOI A;  2O8J A; 
#chains in the Genus database with same CATH homology
 5HQ8 A;  3OXG A;  4BUP A;  3QWP A;  3M58 A;  3S7J A;  3RU0 A;  2G46 A;  4LDG A;  4Z4P A;  4YNP A;  1N6C A;  5T0M A;  5F59 A;  2BQZ A;  3S7D A;  1PEG A;  4QEO A;  5HI7 A;  2QPW A;  5JHN A;  3F9W A;  1MT6 A;  4AU7 A;  5JIY A;  3KMT A;  3OXL A;  4J7F A;  5JIN A;  3F9Z A;  3EP0 A;  1N3J A;  4YPE A;  4MI0 A;  5ARF A;  3MO2 A;  3KMA A;  3HNA A;  2RFI A;  3KMJ A;  3M53 A;  4RZ0 A;  5F5E A;  3CBM A;  3OXF A;  4J83 A;  3CBO A;  1H3I A;  3QWV A;  5CCL A;  2R3A A;  3FPD A;  5F6L A;  3RAY A;  4NVQ A;  2JV0 A;  4IJ8 A;  3M57 A;  5TTF A;  4YNM A;  5LSX A;  1N6A A;  3F9X A;  5T0K A;  3MO5 A;  3K5K A;  3CBP A;  4NJ5 A;  3VV0 A;  2W5Z A;  5EG2 A;  5T5G A;  3MO0 A;  4FMU A;  4QEN A;  3S7B A;  3DB5 A;  4O30 A;  3QWW A;  3M59 A;  4WUY A;  3SWC A;  1MUF A;  5KJL A;  1XQH A;  3PDN A;  5EX3 A;  4J8O A;  5KJN A;  3DAL A;  4YPA A;  4YPU A;  5KJM A;  3S8P A;  3TG5 A;  3RQ4 A;  3OS5 A;  5EX0 A;  3OPE A;  3M5A A;  4J7I A;  1O9S A;  2F69 A;  3S7F A;  4YND A;  3TG4 A;  4QEP A;  4C1Q A;  3MEK A;  4E47 A;  1MVH A;  4JLG A;  5ARG A;  5JJ0 A;  5CPR B;  3VUZ A;  5F6K C;  3M55 A;  4O6F A;  4H12 A;  3M56 A;  2IGQ A;  3RIB A;  4MI5 A;  4JDS A;  4I51 A;  3RJW A;  5KJK A;  3SW9 A;  4IJD A;  1ZKK A;  3IHX A;  5LSZ A;  2W5Y A;  1MVX A;  5TEG A;  5TH7 A;  1ML9 A;  3F9Y A;  5AYF A;  3M54 A;  3N71 A;  3BO5 A;  5CCM A;  3OOI A;  2O8J A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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