5JIYA

Structure of g9a set-domain with histone h3k9norleucine mutant peptide and bound s-adenosylmethionine
Total Genus 79
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
79
sequence length
273
structure length
273
Chain Sequence
IRTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Histone-lysine N-methyltransferase EHMT2
publication title S-adenosyl methionine is necessary for inhibition of the methyltransferase G9a by the lysine 9 to methionine mutation on histone H3.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Transferase
total genus 79
structure length 273
sequence length 273
chains with identical sequence B
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2016-04-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF05033 Pre-SET Pre-SET motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 5jiyA00
4JLGA 5F5EA 3CBOA 4J7FA 4J83A 3S7FA 3QWPA 2BQZA 3RJWA 4QENA 3RQ4A 1ML9A 3KMTA 5EX0A 3N71A 3K5KA 3S7BA 5TEGA 1MUFA 4MI5A 1N6CA 3F9WA 1MT6A 3DB5A 4H12A 3RAYA 4IJDA 1MVXA 3M54A 4YPUA 5CPRB 2IGQA 3VV0A 3M56A 5ARFA 5T5GA 4JDSA 4BUPA 1H3IA 4MI0A 3MO2A 5HQ8A 5KJLA 1N6AA 4I51A 3FPDA 3OS5A 3S7JA 4YPAA 5KJKA 4YNDA 3CBPA 3MEKA 4YNMA 2G46A 3F9ZA 4J8OA 4Z4PA 5TH7A 5AYFA 3OOIA 2W5ZA 3M57A 5T0MA 3IHXA 2JV0A 4NVQA 4FMUA 5LSXA 4QEPA 2O8JA 3OPEA 5ARGA 3QWVA 3MO5A 3M55A 5JIYA 4YPEA 3PDNA 1N3JA 4C1QA 2R3AA 5EX3A 5TTFA 5EG2A 4NJ5A 4WUYA 5F6LA 2F69A 4LDGA 4O30A 3OXGA 5F59A 3TG5A 3OXFA 1ZKKA 5KJNA 3OXLA 4RZ0A 3F9XA 5CCLA 3M58A 3SW9A 4O6FA 5KJMA 2QPWA 5F6KC 3CBMA 3SWCA 1O9SA 3MO0A 5T0KA 3QWWA 5JJ0A 5CCMA 3M53A 3VUZA 3RIBA 2W5YA 3KMJA 5HI7A 1XQHA 1PEGA 3S8PA 4J7IA 3M5AA 1MVHA 4E47A 3S7DA 3F9YA 3RU0A 5JHNA 3TG4A 3EP0A 3DALA 3KMAA 3HNAA 4QEOA 3BO5A 5JINA 2RFIA 4AU7A 5LSZA 4IJ8A 3M59A 4YNPA
chains in the Genus database with same CATH superfamily
4JLGA 5F5EA 3CBOA 4J7FA 4J83A 3S7FA 3QWPA 2BQZA 3RJWA 4QENA 3RQ4A 1ML9A 3KMTA 5EX0A 3N71A 3K5KA 3S7BA 5TEGA 1MUFA 4MI5A 1N6CA 3F9WA 1MT6A 3DB5A 4H12A 3RAYA 4IJDA 1MVXA 3M54A 4YPUA 5CPRB 2IGQA 3VV0A 3M56A 5ARFA 5T5GA 4JDSA 4BUPA 1H3IA 4MI0A 3MO2A 5HQ8A 5KJLA 1N6AA 4I51A 3FPDA 3OS5A 3S7JA 4YPAA 5KJKA 4YNDA 3CBPA 3MEKA 4YNMA 2G46A 3F9ZA 4J8OA 4Z4PA 5TH7A 5AYFA 3OOIA 2W5ZA 3M57A 5T0MA 3IHXA 2JV0A 4NVQA 4FMUA 5LSXA 4QEPA 2O8JA 3OPEA 5ARGA 3QWVA 3MO5A 3M55A 5JIYA 4YPEA 3PDNA 1N3JA 4C1QA 2R3AA 5EX3A 5TTFA 5EG2A 4NJ5A 4WUYA 5F6LA 2F69A 4LDGA 4O30A 3OXGA 5F59A 3TG5A 3OXFA 1ZKKA 5KJNA 3OXLA 4RZ0A 3F9XA 5CCLA 3M58A 3SW9A 4O6FA 5KJMA 2QPWA 5F6KC 3CBMA 3SWCA 1O9SA 3MO0A 5T0KA 3QWWA 5JJ0A 5CCMA 3M53A 3VUZA 3RIBA 2W5YA 3KMJA 5HI7A 1XQHA 1PEGA 3S8PA 4J7IA 3M5AA 1MVHA 4E47A 3S7DA 3F9YA 3RU0A 5JHNA 3TG4A 3EP0A 3DALA 3KMAA 3HNAA 4QEOA 3BO5A 5JINA 2RFIA 4AU7A 5LSZA 4IJ8A 3M59A 4YNPA
chains in the Genus database with same CATH topology
4JLGA 5F5EA 3CBOA 4J7FA 4J83A 3S7FA 3QWPA 2BQZA 3RJWA 4QENA 3RQ4A 1ML9A 3KMTA 5EX0A 3N71A 3K5KA 3S7BA 5TEGA 1MUFA 4MI5A 1N6CA 3F9WA 1MT6A 3DB5A 4H12A 3RAYA 4IJDA 1MVXA 3M54A 4YPUA 5CPRB 2IGQA 3VV0A 3M56A 5ARFA 5T5GA 4JDSA 4BUPA 1H3IA 4MI0A 3MO2A 5HQ8A 5KJLA 1N6AA 4I51A 3FPDA 3OS5A 3S7JA 4YPAA 5KJKA 4YNDA 3CBPA 3MEKA 4YNMA 2G46A 3F9ZA 4J8OA 4Z4PA 5TH7A 5AYFA 3OOIA 2W5ZA 3M57A 5T0MA 3IHXA 2JV0A 4NVQA 4FMUA 5LSXA 4QEPA 2O8JA 3OPEA 5ARGA 3QWVA 3MO5A 3M55A 5JIYA 4YPEA 3PDNA 1N3JA 4C1QA 2R3AA 5EX3A 5TTFA 5EG2A 4NJ5A 4WUYA 5F6LA 2F69A 4LDGA 4O30A 3OXGA 5F59A 3TG5A 3OXFA 1ZKKA 5KJNA 3OXLA 4RZ0A 3F9XA 5CCLA 3M58A 3SW9A 4O6FA 5KJMA 2QPWA 5F6KC 3CBMA 3SWCA 1O9SA 3MO0A 5T0KA 3QWWA 5JJ0A 5CCMA 3M53A 3VUZA 3RIBA 2W5YA 3KMJA 5HI7A 1XQHA 1PEGA 3S8PA 4J7IA 3M5AA 1MVHA 4E47A 3S7DA 3F9YA 3RU0A 5JHNA 3TG4A 3EP0A 3DALA 3KMAA 3HNAA 4QEOA 3BO5A 5JINA 2RFIA 4AU7A 5LSZA 4IJ8A 3M59A 4YNPA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4JLG A;  5F5E A;  3CBO A;  4J7F A;  4J83 A;  3S7F A;  3QWP A;  2BQZ A;  3RJW A;  4QEN A;  3RQ4 A;  1ML9 A;  3KMT A;  5EX0 A;  3N71 A;  3K5K A;  3S7B A;  5TEG A;  1MUF A;  4MI5 A;  1N6C A;  3F9W A;  1MT6 A;  3DB5 A;  4H12 A;  3RAY A;  4IJD A;  1MVX A;  3M54 A;  4YPU A;  5CPR B;  2IGQ A;  3VV0 A;  3M56 A;  5ARF A;  5T5G A;  4JDS A;  4BUP A;  1H3I A;  4MI0 A;  3MO2 A;  5HQ8 A;  5KJL A;  1N6A A;  4I51 A;  3FPD A;  3OS5 A;  3S7J A;  4YPA A;  5KJK A;  4YND A;  3CBP A;  3MEK A;  4YNM A;  2G46 A;  3F9Z A;  4J8O A;  4Z4P A;  5TH7 A;  5AYF A;  3OOI A;  2W5Z A;  3M57 A;  5T0M A;  3IHX A;  2JV0 A;  4NVQ A;  4FMU A;  5LSX A;  4QEP A;  2O8J A;  3OPE A;  5ARG A;  3QWV A;  3MO5 A;  3M55 A;  5JIY A;  4YPE A;  3PDN A;  1N3J A;  4C1Q A;  2R3A A;  5EX3 A;  5TTF A;  5EG2 A;  4NJ5 A;  4WUY A;  5F6L A;  2F69 A;  4LDG A;  4O30 A;  3OXG A;  5F59 A;  3TG5 A;  3OXF A;  1ZKK A;  5KJN A;  3OXL A;  4RZ0 A;  3F9X A;  5CCL A;  3M58 A;  3SW9 A;  4O6F A;  5KJM A;  2QPW A;  5F6K C;  3CBM A;  3SWC A;  1O9S A;  3MO0 A;  5T0K A;  3QWW A;  5JJ0 A;  5CCM A;  3M53 A;  3VUZ A;  3RIB A;  2W5Y A;  3KMJ A;  5HI7 A;  1XQH A;  1PEG A;  3S8P A;  4J7I A;  3M5A A;  1MVH A;  4E47 A;  3S7D A;  3F9Y A;  3RU0 A;  5JHN A;  3TG4 A;  3EP0 A;  3DAL A;  3KMA A;  3HNA A;  4QEO A;  3BO5 A;  5JIN A;  2RFI A;  4AU7 A;  5LSZ A;  4IJ8 A;  3M59 A;  4YNP A; 
#chains in the Genus database with same CATH topology
 4JLG A;  5F5E A;  3CBO A;  4J7F A;  4J83 A;  3S7F A;  3QWP A;  2BQZ A;  3RJW A;  4QEN A;  3RQ4 A;  1ML9 A;  3KMT A;  5EX0 A;  3N71 A;  3K5K A;  3S7B A;  5TEG A;  1MUF A;  4MI5 A;  1N6C A;  3F9W A;  1MT6 A;  3DB5 A;  4H12 A;  3RAY A;  4IJD A;  1MVX A;  3M54 A;  4YPU A;  5CPR B;  2IGQ A;  3VV0 A;  3M56 A;  5ARF A;  5T5G A;  4JDS A;  4BUP A;  1H3I A;  4MI0 A;  3MO2 A;  5HQ8 A;  5KJL A;  1N6A A;  4I51 A;  3FPD A;  3OS5 A;  3S7J A;  4YPA A;  5KJK A;  4YND A;  3CBP A;  3MEK A;  4YNM A;  2G46 A;  3F9Z A;  4J8O A;  4Z4P A;  5TH7 A;  5AYF A;  3OOI A;  2W5Z A;  3M57 A;  5T0M A;  3IHX A;  2JV0 A;  4NVQ A;  4FMU A;  5LSX A;  4QEP A;  2O8J A;  3OPE A;  5ARG A;  3QWV A;  3MO5 A;  3M55 A;  5JIY A;  4YPE A;  3PDN A;  1N3J A;  4C1Q A;  2R3A A;  5EX3 A;  5TTF A;  5EG2 A;  4NJ5 A;  4WUY A;  5F6L A;  2F69 A;  4LDG A;  4O30 A;  3OXG A;  5F59 A;  3TG5 A;  3OXF A;  1ZKK A;  5KJN A;  3OXL A;  4RZ0 A;  3F9X A;  5CCL A;  3M58 A;  3SW9 A;  4O6F A;  5KJM A;  2QPW A;  5F6K C;  3CBM A;  3SWC A;  1O9S A;  3MO0 A;  5T0K A;  3QWW A;  5JJ0 A;  5CCM A;  3M53 A;  3VUZ A;  3RIB A;  2W5Y A;  3KMJ A;  5HI7 A;  1XQH A;  1PEG A;  3S8P A;  4J7I A;  3M5A A;  1MVH A;  4E47 A;  3S7D A;  3F9Y A;  3RU0 A;  5JHN A;  3TG4 A;  3EP0 A;  3DAL A;  3KMA A;  3HNA A;  4QEO A;  3BO5 A;  5JIN A;  2RFI A;  4AU7 A;  5LSZ A;  4IJ8 A;  3M59 A;  4YNP A; 
#chains in the Genus database with same CATH homology
 4JLG A;  5F5E A;  3CBO A;  4J7F A;  4J83 A;  3S7F A;  3QWP A;  2BQZ A;  3RJW A;  4QEN A;  3RQ4 A;  1ML9 A;  3KMT A;  5EX0 A;  3N71 A;  3K5K A;  3S7B A;  5TEG A;  1MUF A;  4MI5 A;  1N6C A;  3F9W A;  1MT6 A;  3DB5 A;  4H12 A;  3RAY A;  4IJD A;  1MVX A;  3M54 A;  4YPU A;  5CPR B;  2IGQ A;  3VV0 A;  3M56 A;  5ARF A;  5T5G A;  4JDS A;  4BUP A;  1H3I A;  4MI0 A;  3MO2 A;  5HQ8 A;  5KJL A;  1N6A A;  4I51 A;  3FPD A;  3OS5 A;  3S7J A;  4YPA A;  5KJK A;  4YND A;  3CBP A;  3MEK A;  4YNM A;  2G46 A;  3F9Z A;  4J8O A;  4Z4P A;  5TH7 A;  5AYF A;  3OOI A;  2W5Z A;  3M57 A;  5T0M A;  3IHX A;  2JV0 A;  4NVQ A;  4FMU A;  5LSX A;  4QEP A;  2O8J A;  3OPE A;  5ARG A;  3QWV A;  3MO5 A;  3M55 A;  5JIY A;  4YPE A;  3PDN A;  1N3J A;  4C1Q A;  2R3A A;  5EX3 A;  5TTF A;  5EG2 A;  4NJ5 A;  4WUY A;  5F6L A;  2F69 A;  4LDG A;  4O30 A;  3OXG A;  5F59 A;  3TG5 A;  3OXF A;  1ZKK A;  5KJN A;  3OXL A;  4RZ0 A;  3F9X A;  5CCL A;  3M58 A;  3SW9 A;  4O6F A;  5KJM A;  2QPW A;  5F6K C;  3CBM A;  3SWC A;  1O9S A;  3MO0 A;  5T0K A;  3QWW A;  5JJ0 A;  5CCM A;  3M53 A;  3VUZ A;  3RIB A;  2W5Y A;  3KMJ A;  5HI7 A;  1XQH A;  1PEG A;  3S8P A;  4J7I A;  3M5A A;  1MVH A;  4E47 A;  3S7D A;  3F9Y A;  3RU0 A;  5JHN A;  3TG4 A;  3EP0 A;  3DAL A;  3KMA A;  3HNA A;  4QEO A;  3BO5 A;  5JIN A;  2RFI A;  4AU7 A;  5LSZ A;  4IJ8 A;  3M59 A;  4YNP A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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