5JIYA

Structure of g9a set-domain with histone h3k9norleucine mutant peptide and bound s-adenosylmethionine
Total Genus 79
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
79
sequence length
273
structure length
273
Chain Sequence
b'IRTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSR'
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Histone-lysine N-methyltransferase EHMT2
publication title S-adenosyl methionine is necessary for inhibition of the methyltransferase G9a by the lysine 9 to methionine mutation on histone H3.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Transferase
total genus 79
structure length 273
sequence length 273
chains with identical sequence B
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2016-04-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF05033 Pre-SET Pre-SET motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 5jiyA00
4IJDA 5KJLA 3QWPA 5HQ8A 5AYFA 4E47A 3F9XA 5ARGA 5CPRB 1ZKKA 3F9YA 3OXLA 3VUZA 3MO2A 3S7BA 5T5GA 3EP0A 5F5EA 5ARFA 5CCLA 5LSXA 2BQZA 3VV0A 3KMTA 4QEPA 3SWCA 1PEGA 3TG5A 1MVXA 1MVHA 3DALA 3PDNA 4Z4PA 3DB5A 3OOIA 3OXGA 3MO5A 4YNMA 5TTFA 4H12A 4J7IA 2JV0A 1N6CA 3RIBA 1N6AA 4YPEA 4QEOA 4YNPA 4LDGA 1MUFA 3F9WA 4BUPA 5JHNA 1XQHA 5JIYA 2F69A 4JLGA 5KJKA 4MI0A 4WUYA 5F59A 3RAYA 4I51A 5JINA 2IGQA 3S7DA 5EX0A 4JDSA 3OPEA 2G46A 4YPUA 1O9SA 5EG2A 3OXFA 4QENA 3MO0A 5EX3A 1ML9A 3CBOA 3N71A 4NVQA 3TG4A 3KMJA 3IHXA 5CCMA 4IJ8A 2QPWA 3F9ZA 1N3JA 4J83A 4C1QA 5TEGA 3FPDA 3MEKA 3M57A 3BO5A 5KJNA 3K5KA 2RFIA 5T0MA 4J8OA 3KMAA 5LSZA 3M59A 4FMUA 3QWWA 5F6KC 4YNDA 2W5YA 5TH7A 3CBPA 5KJMA 3OS5A 3SW9A 3M53A 3M54A 4J7FA 3CBMA 5T0KA 3RQ4A 3HNAA 3S8PA 2O8JA 3M55A 4RZ0A 5HI7A 4O6FA 5JJ0A 1MT6A 3S7JA 1H3IA 4YPAA 2W5ZA 3M56A 4O30A 5F6LA 4NJ5A 3M5AA 3S7FA 4MI5A 4AU7A 3M58A 3RJWA 2R3AA 3RU0A 3QWVA
chains in the Genus database with same CATH superfamily
4IJDA 5KJLA 3QWPA 5HQ8A 5AYFA 4E47A 3F9XA 5ARGA 5CPRB 1ZKKA 3F9YA 3OXLA 3VUZA 3MO2A 3S7BA 5T5GA 3EP0A 5F5EA 5ARFA 5CCLA 5LSXA 2BQZA 3VV0A 3KMTA 4QEPA 3SWCA 1PEGA 3TG5A 1MVXA 1MVHA 3DALA 3PDNA 4Z4PA 3DB5A 3OOIA 3OXGA 3MO5A 4YNMA 5TTFA 4H12A 4J7IA 2JV0A 1N6CA 3RIBA 1N6AA 4YPEA 4QEOA 4YNPA 4LDGA 1MUFA 3F9WA 4BUPA 5JHNA 1XQHA 5JIYA 2F69A 4JLGA 5KJKA 4MI0A 4WUYA 5F59A 3RAYA 4I51A 5JINA 2IGQA 3S7DA 5EX0A 4JDSA 3OPEA 2G46A 4YPUA 1O9SA 5EG2A 3OXFA 4QENA 3MO0A 5EX3A 1ML9A 3CBOA 3N71A 4NVQA 3TG4A 3KMJA 3IHXA 5CCMA 4IJ8A 2QPWA 3F9ZA 1N3JA 4J83A 4C1QA 5TEGA 3FPDA 3MEKA 3M57A 3BO5A 5KJNA 3K5KA 2RFIA 5T0MA 4J8OA 3KMAA 5LSZA 3M59A 4FMUA 3QWWA 5F6KC 4YNDA 2W5YA 5TH7A 3CBPA 5KJMA 3OS5A 3SW9A 3M53A 3M54A 4J7FA 3CBMA 5T0KA 3RQ4A 3HNAA 3S8PA 2O8JA 3M55A 4RZ0A 5HI7A 4O6FA 5JJ0A 1MT6A 3S7JA 1H3IA 4YPAA 2W5ZA 3M56A 4O30A 5F6LA 4NJ5A 3M5AA 3S7FA 4MI5A 4AU7A 3M58A 3RJWA 2R3AA 3RU0A 3QWVA
chains in the Genus database with same CATH topology
4IJDA 5KJLA 3QWPA 5HQ8A 5AYFA 4E47A 3F9XA 5ARGA 5CPRB 1ZKKA 3F9YA 3OXLA 3VUZA 3MO2A 3S7BA 5T5GA 3EP0A 5F5EA 5ARFA 5CCLA 5LSXA 2BQZA 3VV0A 3KMTA 4QEPA 3SWCA 1PEGA 3TG5A 1MVXA 1MVHA 3DALA 3PDNA 4Z4PA 3DB5A 3OOIA 3OXGA 3MO5A 4YNMA 5TTFA 4H12A 4J7IA 2JV0A 1N6CA 3RIBA 1N6AA 4YPEA 4QEOA 4YNPA 4LDGA 1MUFA 3F9WA 4BUPA 5JHNA 1XQHA 5JIYA 2F69A 4JLGA 5KJKA 4MI0A 4WUYA 5F59A 3RAYA 4I51A 5JINA 2IGQA 3S7DA 5EX0A 4JDSA 3OPEA 2G46A 4YPUA 1O9SA 5EG2A 3OXFA 4QENA 3MO0A 5EX3A 1ML9A 3CBOA 3N71A 4NVQA 3TG4A 3KMJA 3IHXA 5CCMA 4IJ8A 2QPWA 3F9ZA 1N3JA 4J83A 4C1QA 5TEGA 3FPDA 3MEKA 3M57A 3BO5A 5KJNA 3K5KA 2RFIA 5T0MA 4J8OA 3KMAA 5LSZA 3M59A 4FMUA 3QWWA 5F6KC 4YNDA 2W5YA 5TH7A 3CBPA 5KJMA 3OS5A 3SW9A 3M53A 3M54A 4J7FA 3CBMA 5T0KA 3RQ4A 3HNAA 3S8PA 2O8JA 3M55A 4RZ0A 5HI7A 4O6FA 5JJ0A 1MT6A 3S7JA 1H3IA 4YPAA 2W5ZA 3M56A 4O30A 5F6LA 4NJ5A 3M5AA 3S7FA 4MI5A 4AU7A 3M58A 3RJWA 2R3AA 3RU0A 3QWVA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4IJD A;  5KJL A;  3QWP A;  5HQ8 A;  5AYF A;  4E47 A;  3F9X A;  5ARG A;  5CPR B;  1ZKK A;  3F9Y A;  3OXL A;  3VUZ A;  3MO2 A;  3S7B A;  5T5G A;  3EP0 A;  5F5E A;  5ARF A;  5CCL A;  5LSX A;  2BQZ A;  3VV0 A;  3KMT A;  4QEP A;  3SWC A;  1PEG A;  3TG5 A;  1MVX A;  1MVH A;  3DAL A;  3PDN A;  4Z4P A;  3DB5 A;  3OOI A;  3OXG A;  3MO5 A;  4YNM A;  5TTF A;  4H12 A;  4J7I A;  2JV0 A;  1N6C A;  3RIB A;  1N6A A;  4YPE A;  4QEO A;  4YNP A;  4LDG A;  1MUF A;  3F9W A;  4BUP A;  5JHN A;  1XQH A;  5JIY A;  2F69 A;  4JLG A;  5KJK A;  4MI0 A;  4WUY A;  5F59 A;  3RAY A;  4I51 A;  5JIN A;  2IGQ A;  3S7D A;  5EX0 A;  4JDS A;  3OPE A;  2G46 A;  4YPU A;  1O9S A;  5EG2 A;  3OXF A;  4QEN A;  3MO0 A;  5EX3 A;  1ML9 A;  3CBO A;  3N71 A;  4NVQ A;  3TG4 A;  3KMJ A;  3IHX A;  5CCM A;  4IJ8 A;  2QPW A;  3F9Z A;  1N3J A;  4J83 A;  4C1Q A;  5TEG A;  3FPD A;  3MEK A;  3M57 A;  3BO5 A;  5KJN A;  3K5K A;  2RFI A;  5T0M A;  4J8O A;  3KMA A;  5LSZ A;  3M59 A;  4FMU A;  3QWW A;  5F6K C;  4YND A;  2W5Y A;  5TH7 A;  3CBP A;  5KJM A;  3OS5 A;  3SW9 A;  3M53 A;  3M54 A;  4J7F A;  3CBM A;  5T0K A;  3RQ4 A;  3HNA A;  3S8P A;  2O8J A;  3M55 A;  4RZ0 A;  5HI7 A;  4O6F A;  5JJ0 A;  1MT6 A;  3S7J A;  1H3I A;  4YPA A;  2W5Z A;  3M56 A;  4O30 A;  5F6L A;  4NJ5 A;  3M5A A;  3S7F A;  4MI5 A;  4AU7 A;  3M58 A;  3RJW A;  2R3A A;  3RU0 A;  3QWV A; 
#chains in the Genus database with same CATH topology
 4IJD A;  5KJL A;  3QWP A;  5HQ8 A;  5AYF A;  4E47 A;  3F9X A;  5ARG A;  5CPR B;  1ZKK A;  3F9Y A;  3OXL A;  3VUZ A;  3MO2 A;  3S7B A;  5T5G A;  3EP0 A;  5F5E A;  5ARF A;  5CCL A;  5LSX A;  2BQZ A;  3VV0 A;  3KMT A;  4QEP A;  3SWC A;  1PEG A;  3TG5 A;  1MVX A;  1MVH A;  3DAL A;  3PDN A;  4Z4P A;  3DB5 A;  3OOI A;  3OXG A;  3MO5 A;  4YNM A;  5TTF A;  4H12 A;  4J7I A;  2JV0 A;  1N6C A;  3RIB A;  1N6A A;  4YPE A;  4QEO A;  4YNP A;  4LDG A;  1MUF A;  3F9W A;  4BUP A;  5JHN A;  1XQH A;  5JIY A;  2F69 A;  4JLG A;  5KJK A;  4MI0 A;  4WUY A;  5F59 A;  3RAY A;  4I51 A;  5JIN A;  2IGQ A;  3S7D A;  5EX0 A;  4JDS A;  3OPE A;  2G46 A;  4YPU A;  1O9S A;  5EG2 A;  3OXF A;  4QEN A;  3MO0 A;  5EX3 A;  1ML9 A;  3CBO A;  3N71 A;  4NVQ A;  3TG4 A;  3KMJ A;  3IHX A;  5CCM A;  4IJ8 A;  2QPW A;  3F9Z A;  1N3J A;  4J83 A;  4C1Q A;  5TEG A;  3FPD A;  3MEK A;  3M57 A;  3BO5 A;  5KJN A;  3K5K A;  2RFI A;  5T0M A;  4J8O A;  3KMA A;  5LSZ A;  3M59 A;  4FMU A;  3QWW A;  5F6K C;  4YND A;  2W5Y A;  5TH7 A;  3CBP A;  5KJM A;  3OS5 A;  3SW9 A;  3M53 A;  3M54 A;  4J7F A;  3CBM A;  5T0K A;  3RQ4 A;  3HNA A;  3S8P A;  2O8J A;  3M55 A;  4RZ0 A;  5HI7 A;  4O6F A;  5JJ0 A;  1MT6 A;  3S7J A;  1H3I A;  4YPA A;  2W5Z A;  3M56 A;  4O30 A;  5F6L A;  4NJ5 A;  3M5A A;  3S7F A;  4MI5 A;  4AU7 A;  3M58 A;  3RJW A;  2R3A A;  3RU0 A;  3QWV A; 
#chains in the Genus database with same CATH homology
 4IJD A;  5KJL A;  3QWP A;  5HQ8 A;  5AYF A;  4E47 A;  3F9X A;  5ARG A;  5CPR B;  1ZKK A;  3F9Y A;  3OXL A;  3VUZ A;  3MO2 A;  3S7B A;  5T5G A;  3EP0 A;  5F5E A;  5ARF A;  5CCL A;  5LSX A;  2BQZ A;  3VV0 A;  3KMT A;  4QEP A;  3SWC A;  1PEG A;  3TG5 A;  1MVX A;  1MVH A;  3DAL A;  3PDN A;  4Z4P A;  3DB5 A;  3OOI A;  3OXG A;  3MO5 A;  4YNM A;  5TTF A;  4H12 A;  4J7I A;  2JV0 A;  1N6C A;  3RIB A;  1N6A A;  4YPE A;  4QEO A;  4YNP A;  4LDG A;  1MUF A;  3F9W A;  4BUP A;  5JHN A;  1XQH A;  5JIY A;  2F69 A;  4JLG A;  5KJK A;  4MI0 A;  4WUY A;  5F59 A;  3RAY A;  4I51 A;  5JIN A;  2IGQ A;  3S7D A;  5EX0 A;  4JDS A;  3OPE A;  2G46 A;  4YPU A;  1O9S A;  5EG2 A;  3OXF A;  4QEN A;  3MO0 A;  5EX3 A;  1ML9 A;  3CBO A;  3N71 A;  4NVQ A;  3TG4 A;  3KMJ A;  3IHX A;  5CCM A;  4IJ8 A;  2QPW A;  3F9Z A;  1N3J A;  4J83 A;  4C1Q A;  5TEG A;  3FPD A;  3MEK A;  3M57 A;  3BO5 A;  5KJN A;  3K5K A;  2RFI A;  5T0M A;  4J8O A;  3KMA A;  5LSZ A;  3M59 A;  4FMU A;  3QWW A;  5F6K C;  4YND A;  2W5Y A;  5TH7 A;  3CBP A;  5KJM A;  3OS5 A;  3SW9 A;  3M53 A;  3M54 A;  4J7F A;  3CBM A;  5T0K A;  3RQ4 A;  3HNA A;  3S8P A;  2O8J A;  3M55 A;  4RZ0 A;  5HI7 A;  4O6F A;  5JJ0 A;  1MT6 A;  3S7J A;  1H3I A;  4YPA A;  2W5Z A;  3M56 A;  4O30 A;  5F6L A;  4NJ5 A;  3M5A A;  3S7F A;  4MI5 A;  4AU7 A;  3M58 A;  3RJW A;  2R3A A;  3RU0 A;  3QWV A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...