2RFIA

Crystal structure of catalytic domain of human euchromatic histone methyltransferase 1 in complex with sah and dimethylated h3k9 peptide
Total Genus 64
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
64
sequence length
261
structure length
261
Chain Sequence
VERIVSRDIARGYERIPIPCVNAVDSEPCPSNYKYVSQNCVTSPMNIDRNITHLQYCVCIDDCSSSNCMCGQLSMRCWYDKDGRLLPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLDNKDGEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIKGKLFSCRCGSPKCRHS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Histone-lysine N-methyltransferase, H3 lysine-9 specific 5
publication title Structural biology of human H3K9 methyltransferases
pubmed doi rcsb
source organism Homo sapiens
molecule tags Transferase
total genus 64
structure length 261
sequence length 261
chains with identical sequence B
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2007-09-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF05033 Pre-SET Pre-SET motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 2rfiA00
3PDNA 3M59A 5F59A 3M58A 4C1QA 3TG5A 4AU7A 3VV0A 3RIBA 5JIYA 3RQ4A 5T0KA 1MUFA 4JDSA 4IJ8A 5EX0A 3M57A 3KMAA 5CPRB 2O8JA 4IJDA 3OXFA 5EX3A 3S7DA 3S7JA 5JJ0A 2R3AA 3OXLA 3MO5A 3EP0A 5KJNA 4O6FA 3SWCA 3F9XA 1N6CA 5TH7A 4QEPA 4BUPA 5EG2A 2QPWA 3RAYA 1MVXA 3IHXA 4YPAA 3S7BA 3KMJA 1PEGA 3QWVA 1MVHA 3M5AA 2F69A 2IGQA 3DB5A 5CCLA 1N3JA 4LDGA 5AYFA 1XQHA 4MI0A 3QWPA 5JINA 1ZKKA 2RFIA 5KJMA 3OOIA 5HQ8A 1ML9A 2W5YA 5F5EA 3OXGA 4YNPA 3CBOA 4QENA 3RU0A 3FPDA 3K5KA 3F9ZA 3RJWA 4NJ5A 3OPEA 5ARFA 3M54A 3S7FA 4J83A 3QWWA 5F6KC 3VUZA 3MO2A 3MEKA 4RZ0A 3HNAA 2G46A 3BO5A 5JHNA 5KJKA 5ARGA 5HI7A 3KMTA 4QEOA 1N6AA 4J7FA 4FMUA 3DALA 4YNDA 5KJLA 3F9WA 3CBMA 5LSXA 4E47A 2BQZA 5T0MA 4I51A 3F9YA 3TG4A 4J8OA 3M55A 4WUYA 4YNMA 3N71A 4YPEA 4YPUA 3MO0A 4JLGA 4Z4PA 2JV0A 5TEGA 1O9SA 4NVQA 5T5GA 3S8PA 5CCMA 4O30A 4J7IA 3M56A 3CBPA 3SW9A 1MT6A 2W5ZA 3OS5A 4MI5A 1H3IA 4H12A 3M53A 5F6LA 5LSZA 5TTFA
chains in the Genus database with same CATH superfamily
3PDNA 3M59A 5F59A 3M58A 4C1QA 3TG5A 4AU7A 3VV0A 3RIBA 5JIYA 3RQ4A 5T0KA 1MUFA 4JDSA 4IJ8A 5EX0A 3M57A 3KMAA 5CPRB 2O8JA 4IJDA 3OXFA 5EX3A 3S7DA 3S7JA 5JJ0A 2R3AA 3OXLA 3MO5A 3EP0A 5KJNA 4O6FA 3SWCA 3F9XA 1N6CA 5TH7A 4QEPA 4BUPA 5EG2A 2QPWA 3RAYA 1MVXA 3IHXA 4YPAA 3S7BA 3KMJA 1PEGA 3QWVA 1MVHA 3M5AA 2F69A 2IGQA 3DB5A 5CCLA 1N3JA 4LDGA 5AYFA 1XQHA 4MI0A 3QWPA 5JINA 1ZKKA 2RFIA 5KJMA 3OOIA 5HQ8A 1ML9A 2W5YA 5F5EA 3OXGA 4YNPA 3CBOA 4QENA 3RU0A 3FPDA 3K5KA 3F9ZA 3RJWA 4NJ5A 3OPEA 5ARFA 3M54A 3S7FA 4J83A 3QWWA 5F6KC 3VUZA 3MO2A 3MEKA 4RZ0A 3HNAA 2G46A 3BO5A 5JHNA 5KJKA 5ARGA 5HI7A 3KMTA 4QEOA 1N6AA 4J7FA 4FMUA 3DALA 4YNDA 5KJLA 3F9WA 3CBMA 5LSXA 4E47A 2BQZA 5T0MA 4I51A 3F9YA 3TG4A 4J8OA 3M55A 4WUYA 4YNMA 3N71A 4YPEA 4YPUA 3MO0A 4JLGA 4Z4PA 2JV0A 5TEGA 1O9SA 4NVQA 5T5GA 3S8PA 5CCMA 4O30A 4J7IA 3M56A 3CBPA 3SW9A 1MT6A 2W5ZA 3OS5A 4MI5A 1H3IA 4H12A 3M53A 5F6LA 5LSZA 5TTFA
chains in the Genus database with same CATH topology
3PDNA 3M59A 5F59A 3M58A 4C1QA 3TG5A 4AU7A 3VV0A 3RIBA 5JIYA 3RQ4A 5T0KA 1MUFA 4JDSA 4IJ8A 5EX0A 3M57A 3KMAA 5CPRB 2O8JA 4IJDA 3OXFA 5EX3A 3S7DA 3S7JA 5JJ0A 2R3AA 3OXLA 3MO5A 3EP0A 5KJNA 4O6FA 3SWCA 3F9XA 1N6CA 5TH7A 4QEPA 4BUPA 5EG2A 2QPWA 3RAYA 1MVXA 3IHXA 4YPAA 3S7BA 3KMJA 1PEGA 3QWVA 1MVHA 3M5AA 2F69A 2IGQA 3DB5A 5CCLA 1N3JA 4LDGA 5AYFA 1XQHA 4MI0A 3QWPA 5JINA 1ZKKA 2RFIA 5KJMA 3OOIA 5HQ8A 1ML9A 2W5YA 5F5EA 3OXGA 4YNPA 3CBOA 4QENA 3RU0A 3FPDA 3K5KA 3F9ZA 3RJWA 4NJ5A 3OPEA 5ARFA 3M54A 3S7FA 4J83A 3QWWA 5F6KC 3VUZA 3MO2A 3MEKA 4RZ0A 3HNAA 2G46A 3BO5A 5JHNA 5KJKA 5ARGA 5HI7A 3KMTA 4QEOA 1N6AA 4J7FA 4FMUA 3DALA 4YNDA 5KJLA 3F9WA 3CBMA 5LSXA 4E47A 2BQZA 5T0MA 4I51A 3F9YA 3TG4A 4J8OA 3M55A 4WUYA 4YNMA 3N71A 4YPEA 4YPUA 3MO0A 4JLGA 4Z4PA 2JV0A 5TEGA 1O9SA 4NVQA 5T5GA 3S8PA 5CCMA 4O30A 4J7IA 3M56A 3CBPA 3SW9A 1MT6A 2W5ZA 3OS5A 4MI5A 1H3IA 4H12A 3M53A 5F6LA 5LSZA 5TTFA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3PDN A;  3M59 A;  5F59 A;  3M58 A;  4C1Q A;  3TG5 A;  4AU7 A;  3VV0 A;  3RIB A;  5JIY A;  3RQ4 A;  5T0K A;  1MUF A;  4JDS A;  4IJ8 A;  5EX0 A;  3M57 A;  3KMA A;  5CPR B;  2O8J A;  4IJD A;  3OXF A;  5EX3 A;  3S7D A;  3S7J A;  5JJ0 A;  2R3A A;  3OXL A;  3MO5 A;  3EP0 A;  5KJN A;  4O6F A;  3SWC A;  3F9X A;  1N6C A;  5TH7 A;  4QEP A;  4BUP A;  5EG2 A;  2QPW A;  3RAY A;  1MVX A;  3IHX A;  4YPA A;  3S7B A;  3KMJ A;  1PEG A;  3QWV A;  1MVH A;  3M5A A;  2F69 A;  2IGQ A;  3DB5 A;  5CCL A;  1N3J A;  4LDG A;  5AYF A;  1XQH A;  4MI0 A;  3QWP A;  5JIN A;  1ZKK A;  2RFI A;  5KJM A;  3OOI A;  5HQ8 A;  1ML9 A;  2W5Y A;  5F5E A;  3OXG A;  4YNP A;  3CBO A;  4QEN A;  3RU0 A;  3FPD A;  3K5K A;  3F9Z A;  3RJW A;  4NJ5 A;  3OPE A;  5ARF A;  3M54 A;  3S7F A;  4J83 A;  3QWW A;  5F6K C;  3VUZ A;  3MO2 A;  3MEK A;  4RZ0 A;  3HNA A;  2G46 A;  3BO5 A;  5JHN A;  5KJK A;  5ARG A;  5HI7 A;  3KMT A;  4QEO A;  1N6A A;  4J7F A;  4FMU A;  3DAL A;  4YND A;  5KJL A;  3F9W A;  3CBM A;  5LSX A;  4E47 A;  2BQZ A;  5T0M A;  4I51 A;  3F9Y A;  3TG4 A;  4J8O A;  3M55 A;  4WUY A;  4YNM A;  3N71 A;  4YPE A;  4YPU A;  3MO0 A;  4JLG A;  4Z4P A;  2JV0 A;  5TEG A;  1O9S A;  4NVQ A;  5T5G A;  3S8P A;  5CCM A;  4O30 A;  4J7I A;  3M56 A;  3CBP A;  3SW9 A;  1MT6 A;  2W5Z A;  3OS5 A;  4MI5 A;  1H3I A;  4H12 A;  3M53 A;  5F6L A;  5LSZ A;  5TTF A; 
#chains in the Genus database with same CATH topology
 3PDN A;  3M59 A;  5F59 A;  3M58 A;  4C1Q A;  3TG5 A;  4AU7 A;  3VV0 A;  3RIB A;  5JIY A;  3RQ4 A;  5T0K A;  1MUF A;  4JDS A;  4IJ8 A;  5EX0 A;  3M57 A;  3KMA A;  5CPR B;  2O8J A;  4IJD A;  3OXF A;  5EX3 A;  3S7D A;  3S7J A;  5JJ0 A;  2R3A A;  3OXL A;  3MO5 A;  3EP0 A;  5KJN A;  4O6F A;  3SWC A;  3F9X A;  1N6C A;  5TH7 A;  4QEP A;  4BUP A;  5EG2 A;  2QPW A;  3RAY A;  1MVX A;  3IHX A;  4YPA A;  3S7B A;  3KMJ A;  1PEG A;  3QWV A;  1MVH A;  3M5A A;  2F69 A;  2IGQ A;  3DB5 A;  5CCL A;  1N3J A;  4LDG A;  5AYF A;  1XQH A;  4MI0 A;  3QWP A;  5JIN A;  1ZKK A;  2RFI A;  5KJM A;  3OOI A;  5HQ8 A;  1ML9 A;  2W5Y A;  5F5E A;  3OXG A;  4YNP A;  3CBO A;  4QEN A;  3RU0 A;  3FPD A;  3K5K A;  3F9Z A;  3RJW A;  4NJ5 A;  3OPE A;  5ARF A;  3M54 A;  3S7F A;  4J83 A;  3QWW A;  5F6K C;  3VUZ A;  3MO2 A;  3MEK A;  4RZ0 A;  3HNA A;  2G46 A;  3BO5 A;  5JHN A;  5KJK A;  5ARG A;  5HI7 A;  3KMT A;  4QEO A;  1N6A A;  4J7F A;  4FMU A;  3DAL A;  4YND A;  5KJL A;  3F9W A;  3CBM A;  5LSX A;  4E47 A;  2BQZ A;  5T0M A;  4I51 A;  3F9Y A;  3TG4 A;  4J8O A;  3M55 A;  4WUY A;  4YNM A;  3N71 A;  4YPE A;  4YPU A;  3MO0 A;  4JLG A;  4Z4P A;  2JV0 A;  5TEG A;  1O9S A;  4NVQ A;  5T5G A;  3S8P A;  5CCM A;  4O30 A;  4J7I A;  3M56 A;  3CBP A;  3SW9 A;  1MT6 A;  2W5Z A;  3OS5 A;  4MI5 A;  1H3I A;  4H12 A;  3M53 A;  5F6L A;  5LSZ A;  5TTF A; 
#chains in the Genus database with same CATH homology
 3PDN A;  3M59 A;  5F59 A;  3M58 A;  4C1Q A;  3TG5 A;  4AU7 A;  3VV0 A;  3RIB A;  5JIY A;  3RQ4 A;  5T0K A;  1MUF A;  4JDS A;  4IJ8 A;  5EX0 A;  3M57 A;  3KMA A;  5CPR B;  2O8J A;  4IJD A;  3OXF A;  5EX3 A;  3S7D A;  3S7J A;  5JJ0 A;  2R3A A;  3OXL A;  3MO5 A;  3EP0 A;  5KJN A;  4O6F A;  3SWC A;  3F9X A;  1N6C A;  5TH7 A;  4QEP A;  4BUP A;  5EG2 A;  2QPW A;  3RAY A;  1MVX A;  3IHX A;  4YPA A;  3S7B A;  3KMJ A;  1PEG A;  3QWV A;  1MVH A;  3M5A A;  2F69 A;  2IGQ A;  3DB5 A;  5CCL A;  1N3J A;  4LDG A;  5AYF A;  1XQH A;  4MI0 A;  3QWP A;  5JIN A;  1ZKK A;  2RFI A;  5KJM A;  3OOI A;  5HQ8 A;  1ML9 A;  2W5Y A;  5F5E A;  3OXG A;  4YNP A;  3CBO A;  4QEN A;  3RU0 A;  3FPD A;  3K5K A;  3F9Z A;  3RJW A;  4NJ5 A;  3OPE A;  5ARF A;  3M54 A;  3S7F A;  4J83 A;  3QWW A;  5F6K C;  3VUZ A;  3MO2 A;  3MEK A;  4RZ0 A;  3HNA A;  2G46 A;  3BO5 A;  5JHN A;  5KJK A;  5ARG A;  5HI7 A;  3KMT A;  4QEO A;  1N6A A;  4J7F A;  4FMU A;  3DAL A;  4YND A;  5KJL A;  3F9W A;  3CBM A;  5LSX A;  4E47 A;  2BQZ A;  5T0M A;  4I51 A;  3F9Y A;  3TG4 A;  4J8O A;  3M55 A;  4WUY A;  4YNM A;  3N71 A;  4YPE A;  4YPU A;  3MO0 A;  4JLG A;  4Z4P A;  2JV0 A;  5TEG A;  1O9S A;  4NVQ A;  5T5G A;  3S8P A;  5CCM A;  4O30 A;  4J7I A;  3M56 A;  3CBP A;  3SW9 A;  1MT6 A;  2W5Z A;  3OS5 A;  4MI5 A;  1H3I A;  4H12 A;  3M53 A;  5F6L A;  5LSZ A;  5TTF A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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