2RFIA

Crystal structure of catalytic domain of human euchromatic histone methyltransferase 1 in complex with sah and dimethylated h3k9 peptide
Total Genus 64
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
64
sequence length
261
structure length
261
Chain Sequence
VERIVSRDIARGYERIPIPCVNAVDSEPCPSNYKYVSQNCVTSPMNIDRNITHLQYCVCIDDCSSSNCMCGQLSMRCWYDKDGRLLPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLDNKDGEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIKGKLFSCRCGSPKCRHS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Transferase
molecule keywords Histone-lysine N-methyltransferase, H3 lysine-9 specific 5
publication title Structural biology of human H3K9 methyltransferases
pubmed doi rcsb
source organism Homo sapiens
total genus 64
structure length 261
sequence length 261
chains with identical sequence B
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2007-09-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF05033 Pre-SET Pre-SET motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 2rfiA00
3QWWA 2QPWA 1ML9A 5LSXA 4QEOA 4YNDA 3SW9A 4NVQA 2O8JA 5KJNA 1N6AA 1N6CA 3KMAA 3PDNA 5KJKA 2BQZA 5AYFA 4MI0A 5HQ8A 4BUPA 4RZ0A 2W5YA 3OXGA 4QEPA 1XQHA 4YNMA 1MUFA 3CBOA 2RFIA 1H3IA 2W5ZA 4YPEA 5T0KA 3TG4A 5JHNA 3MO5A 5JIYA 3RU0A 1N3JA 4MI5A 3M53A 3F9YA 1MVHA 3KMJA 3OOIA 4AU7A 3S8PA 1O9SA 3M58A 3S7FA 5F5EA 5JINA 5TH7A 4J7IA 4YNPA 3EP0A 5CPRB 4YPUA 3OXLA 5HI7A 2JV0A 3M54A 3MO0A 2F69A 3F9XA 5F6KC 2R3AA 1MT6A 3K5KA 3RAYA 3DALA 3IHXA 5JJ0A 1MVXA 5T0MA 3S7BA 3MEKA 2IGQA 5ARGA 5EX0A 4O30A 3BO5A 4FMUA 3FPDA 3HNAA 5F6LA 3QWPA 3MO2A 3RIBA 3OPEA 4J83A 3F9WA 3RQ4A 3M57A 4IJ8A 3F9ZA 3S7DA 3TG5A 4I51A 5T5GA 4JLGA 4O6FA 5TTFA 1PEGA 4NJ5A 3OS5A 4QENA 5ARFA 5KJMA 3SWCA 5EX3A 3M5AA 1ZKKA 5CCMA 5F59A 5LSZA 3M59A 5CCLA 3DB5A 3M56A 3RJWA 5KJLA 4C1QA 3VUZA 3VV0A 4Z4PA 4WUYA 4IJDA 3CBPA 4E47A 4LDGA 3N71A 3KMTA 4J7FA 2G46A 4JDSA 5EG2A 5TEGA 4YPAA 4J8OA 3QWVA 3M55A 3CBMA 3S7JA 3OXFA 4H12A
chains in the Genus database with same CATH superfamily
3QWWA 2QPWA 1ML9A 5LSXA 4QEOA 4YNDA 3SW9A 4NVQA 2O8JA 5KJNA 1N6AA 1N6CA 3KMAA 3PDNA 5KJKA 2BQZA 5AYFA 4MI0A 5HQ8A 4BUPA 4RZ0A 2W5YA 3OXGA 4QEPA 1XQHA 4YNMA 1MUFA 3CBOA 2RFIA 1H3IA 2W5ZA 4YPEA 5T0KA 3TG4A 5JHNA 3MO5A 5JIYA 3RU0A 1N3JA 4MI5A 3M53A 3F9YA 1MVHA 3KMJA 3OOIA 4AU7A 3S8PA 1O9SA 3M58A 3S7FA 5F5EA 5JINA 5TH7A 4J7IA 4YNPA 3EP0A 5CPRB 4YPUA 3OXLA 5HI7A 2JV0A 3M54A 3MO0A 2F69A 3F9XA 5F6KC 2R3AA 1MT6A 3K5KA 3RAYA 3DALA 3IHXA 5JJ0A 1MVXA 5T0MA 3S7BA 3MEKA 2IGQA 5ARGA 5EX0A 4O30A 3BO5A 4FMUA 3FPDA 3HNAA 5F6LA 3QWPA 3MO2A 3RIBA 3OPEA 4J83A 3F9WA 3RQ4A 3M57A 4IJ8A 3F9ZA 3S7DA 3TG5A 4I51A 5T5GA 4JLGA 4O6FA 5TTFA 1PEGA 4NJ5A 3OS5A 4QENA 5ARFA 5KJMA 3SWCA 5EX3A 3M5AA 1ZKKA 5CCMA 5F59A 5LSZA 3M59A 5CCLA 3DB5A 3M56A 3RJWA 5KJLA 4C1QA 3VUZA 3VV0A 4Z4PA 4WUYA 4IJDA 3CBPA 4E47A 4LDGA 3N71A 3KMTA 4J7FA 2G46A 4JDSA 5EG2A 5TEGA 4YPAA 4J8OA 3QWVA 3M55A 3CBMA 3S7JA 3OXFA 4H12A
chains in the Genus database with same CATH topology
3QWWA 2QPWA 1ML9A 5LSXA 4QEOA 4YNDA 3SW9A 4NVQA 2O8JA 5KJNA 1N6AA 1N6CA 3KMAA 3PDNA 5KJKA 2BQZA 5AYFA 4MI0A 5HQ8A 4BUPA 4RZ0A 2W5YA 3OXGA 4QEPA 1XQHA 4YNMA 1MUFA 3CBOA 2RFIA 1H3IA 2W5ZA 4YPEA 5T0KA 3TG4A 5JHNA 3MO5A 5JIYA 3RU0A 1N3JA 4MI5A 3M53A 3F9YA 1MVHA 3KMJA 3OOIA 4AU7A 3S8PA 1O9SA 3M58A 3S7FA 5F5EA 5JINA 5TH7A 4J7IA 4YNPA 3EP0A 5CPRB 4YPUA 3OXLA 5HI7A 2JV0A 3M54A 3MO0A 2F69A 3F9XA 5F6KC 2R3AA 1MT6A 3K5KA 3RAYA 3DALA 3IHXA 5JJ0A 1MVXA 5T0MA 3S7BA 3MEKA 2IGQA 5ARGA 5EX0A 4O30A 3BO5A 4FMUA 3FPDA 3HNAA 5F6LA 3QWPA 3MO2A 3RIBA 3OPEA 4J83A 3F9WA 3RQ4A 3M57A 4IJ8A 3F9ZA 3S7DA 3TG5A 4I51A 5T5GA 4JLGA 4O6FA 5TTFA 1PEGA 4NJ5A 3OS5A 4QENA 5ARFA 5KJMA 3SWCA 5EX3A 3M5AA 1ZKKA 5CCMA 5F59A 5LSZA 3M59A 5CCLA 3DB5A 3M56A 3RJWA 5KJLA 4C1QA 3VUZA 3VV0A 4Z4PA 4WUYA 4IJDA 3CBPA 4E47A 4LDGA 3N71A 3KMTA 4J7FA 2G46A 4JDSA 5EG2A 5TEGA 4YPAA 4J8OA 3QWVA 3M55A 3CBMA 3S7JA 3OXFA 4H12A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3QWW A;  2QPW A;  1ML9 A;  5LSX A;  4QEO A;  4YND A;  3SW9 A;  4NVQ A;  2O8J A;  5KJN A;  1N6A A;  1N6C A;  3KMA A;  3PDN A;  5KJK A;  2BQZ A;  5AYF A;  4MI0 A;  5HQ8 A;  4BUP A;  4RZ0 A;  2W5Y A;  3OXG A;  4QEP A;  1XQH A;  4YNM A;  1MUF A;  3CBO A;  2RFI A;  1H3I A;  2W5Z A;  4YPE A;  5T0K A;  3TG4 A;  5JHN A;  3MO5 A;  5JIY A;  3RU0 A;  1N3J A;  4MI5 A;  3M53 A;  3F9Y A;  1MVH A;  3KMJ A;  3OOI A;  4AU7 A;  3S8P A;  1O9S A;  3M58 A;  3S7F A;  5F5E A;  5JIN A;  5TH7 A;  4J7I A;  4YNP A;  3EP0 A;  5CPR B;  4YPU A;  3OXL A;  5HI7 A;  2JV0 A;  3M54 A;  3MO0 A;  2F69 A;  3F9X A;  5F6K C;  2R3A A;  1MT6 A;  3K5K A;  3RAY A;  3DAL A;  3IHX A;  5JJ0 A;  1MVX A;  5T0M A;  3S7B A;  3MEK A;  2IGQ A;  5ARG A;  5EX0 A;  4O30 A;  3BO5 A;  4FMU A;  3FPD A;  3HNA A;  5F6L A;  3QWP A;  3MO2 A;  3RIB A;  3OPE A;  4J83 A;  3F9W A;  3RQ4 A;  3M57 A;  4IJ8 A;  3F9Z A;  3S7D A;  3TG5 A;  4I51 A;  5T5G A;  4JLG A;  4O6F A;  5TTF A;  1PEG A;  4NJ5 A;  3OS5 A;  4QEN A;  5ARF A;  5KJM A;  3SWC A;  5EX3 A;  3M5A A;  1ZKK A;  5CCM A;  5F59 A;  5LSZ A;  3M59 A;  5CCL A;  3DB5 A;  3M56 A;  3RJW A;  5KJL A;  4C1Q A;  3VUZ A;  3VV0 A;  4Z4P A;  4WUY A;  4IJD A;  3CBP A;  4E47 A;  4LDG A;  3N71 A;  3KMT A;  4J7F A;  2G46 A;  4JDS A;  5EG2 A;  5TEG A;  4YPA A;  4J8O A;  3QWV A;  3M55 A;  3CBM A;  3S7J A;  3OXF A;  4H12 A; 
#chains in the Genus database with same CATH topology
 3QWW A;  2QPW A;  1ML9 A;  5LSX A;  4QEO A;  4YND A;  3SW9 A;  4NVQ A;  2O8J A;  5KJN A;  1N6A A;  1N6C A;  3KMA A;  3PDN A;  5KJK A;  2BQZ A;  5AYF A;  4MI0 A;  5HQ8 A;  4BUP A;  4RZ0 A;  2W5Y A;  3OXG A;  4QEP A;  1XQH A;  4YNM A;  1MUF A;  3CBO A;  2RFI A;  1H3I A;  2W5Z A;  4YPE A;  5T0K A;  3TG4 A;  5JHN A;  3MO5 A;  5JIY A;  3RU0 A;  1N3J A;  4MI5 A;  3M53 A;  3F9Y A;  1MVH A;  3KMJ A;  3OOI A;  4AU7 A;  3S8P A;  1O9S A;  3M58 A;  3S7F A;  5F5E A;  5JIN A;  5TH7 A;  4J7I A;  4YNP A;  3EP0 A;  5CPR B;  4YPU A;  3OXL A;  5HI7 A;  2JV0 A;  3M54 A;  3MO0 A;  2F69 A;  3F9X A;  5F6K C;  2R3A A;  1MT6 A;  3K5K A;  3RAY A;  3DAL A;  3IHX A;  5JJ0 A;  1MVX A;  5T0M A;  3S7B A;  3MEK A;  2IGQ A;  5ARG A;  5EX0 A;  4O30 A;  3BO5 A;  4FMU A;  3FPD A;  3HNA A;  5F6L A;  3QWP A;  3MO2 A;  3RIB A;  3OPE A;  4J83 A;  3F9W A;  3RQ4 A;  3M57 A;  4IJ8 A;  3F9Z A;  3S7D A;  3TG5 A;  4I51 A;  5T5G A;  4JLG A;  4O6F A;  5TTF A;  1PEG A;  4NJ5 A;  3OS5 A;  4QEN A;  5ARF A;  5KJM A;  3SWC A;  5EX3 A;  3M5A A;  1ZKK A;  5CCM A;  5F59 A;  5LSZ A;  3M59 A;  5CCL A;  3DB5 A;  3M56 A;  3RJW A;  5KJL A;  4C1Q A;  3VUZ A;  3VV0 A;  4Z4P A;  4WUY A;  4IJD A;  3CBP A;  4E47 A;  4LDG A;  3N71 A;  3KMT A;  4J7F A;  2G46 A;  4JDS A;  5EG2 A;  5TEG A;  4YPA A;  4J8O A;  3QWV A;  3M55 A;  3CBM A;  3S7J A;  3OXF A;  4H12 A; 
#chains in the Genus database with same CATH homology
 3QWW A;  2QPW A;  1ML9 A;  5LSX A;  4QEO A;  4YND A;  3SW9 A;  4NVQ A;  2O8J A;  5KJN A;  1N6A A;  1N6C A;  3KMA A;  3PDN A;  5KJK A;  2BQZ A;  5AYF A;  4MI0 A;  5HQ8 A;  4BUP A;  4RZ0 A;  2W5Y A;  3OXG A;  4QEP A;  1XQH A;  4YNM A;  1MUF A;  3CBO A;  2RFI A;  1H3I A;  2W5Z A;  4YPE A;  5T0K A;  3TG4 A;  5JHN A;  3MO5 A;  5JIY A;  3RU0 A;  1N3J A;  4MI5 A;  3M53 A;  3F9Y A;  1MVH A;  3KMJ A;  3OOI A;  4AU7 A;  3S8P A;  1O9S A;  3M58 A;  3S7F A;  5F5E A;  5JIN A;  5TH7 A;  4J7I A;  4YNP A;  3EP0 A;  5CPR B;  4YPU A;  3OXL A;  5HI7 A;  2JV0 A;  3M54 A;  3MO0 A;  2F69 A;  3F9X A;  5F6K C;  2R3A A;  1MT6 A;  3K5K A;  3RAY A;  3DAL A;  3IHX A;  5JJ0 A;  1MVX A;  5T0M A;  3S7B A;  3MEK A;  2IGQ A;  5ARG A;  5EX0 A;  4O30 A;  3BO5 A;  4FMU A;  3FPD A;  3HNA A;  5F6L A;  3QWP A;  3MO2 A;  3RIB A;  3OPE A;  4J83 A;  3F9W A;  3RQ4 A;  3M57 A;  4IJ8 A;  3F9Z A;  3S7D A;  3TG5 A;  4I51 A;  5T5G A;  4JLG A;  4O6F A;  5TTF A;  1PEG A;  4NJ5 A;  3OS5 A;  4QEN A;  5ARF A;  5KJM A;  3SWC A;  5EX3 A;  3M5A A;  1ZKK A;  5CCM A;  5F59 A;  5LSZ A;  3M59 A;  5CCL A;  3DB5 A;  3M56 A;  3RJW A;  5KJL A;  4C1Q A;  3VUZ A;  3VV0 A;  4Z4P A;  4WUY A;  4IJD A;  3CBP A;  4E47 A;  4LDG A;  3N71 A;  3KMT A;  4J7F A;  2G46 A;  4JDS A;  5EG2 A;  5TEG A;  4YPA A;  4J8O A;  3QWV A;  3M55 A;  3CBM A;  3S7J A;  3OXF A;  4H12 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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