2RFIA

Crystal structure of catalytic domain of human euchromatic histone methyltransferase 1 in complex with sah and dimethylated h3k9 peptide
Total Genus 64
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
64
sequence length
261
structure length
261
Chain Sequence
VERIVSRDIARGYERIPIPCVNAVDSEPCPSNYKYVSQNCVTSPMNIDRNITHLQYCVCIDDCSSSNCMCGQLSMRCWYDKDGRLLPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLDNKDGEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIKGKLFSCRCGSPKCRHS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural biology of human H3K9 methyltransferases
pubmed doi rcsb
source organism Homo sapiens
molecule tags Transferase
molecule keywords Histone-lysine N-methyltransferase, H3 lysine-9 specific 5
total genus 64
structure length 261
sequence length 261
chains with identical sequence B
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2007-09-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF05033 Pre-SET Pre-SET motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 2rfiA00
3RAYA 3RQ4A 4QEOA 3S7BA 4YPEA 4YNPA 4O30A 3M57A 4FMUA 5HI7A 2IGQA 5LSZA 3SWCA 4LDGA 4I51A 5TTFA 5KJLA 1N3JA 4NVQA 5EX3A 1MVXA 3RU0A 1PEGA 3M53A 5KJMA 3KMAA 4J7FA 5T5GA 5KJNA 1N6AA 5ARFA 1MT6A 3EP0A 4JDSA 5JJ0A 3QWWA 1XQHA 2W5YA 3QWVA 4JLGA 5F59A 3N71A 3S8PA 4Z4PA 4YNDA 3MO2A 5F5EA 3S7FA 1MUFA 3F9YA 4J8OA 3RJWA 4IJDA 5T0KA 1H3IA 3K5KA 3OXFA 4RZ0A 4IJ8A 3SW9A 3TG4A 5HQ8A 5EG2A 5JIYA 5TEGA 3OXGA 3S7JA 5KJKA 3CBPA 3OXLA 3RIBA 4YPUA 3HNAA 2F69A 3KMTA 3BO5A 3FPDA 3M54A 4YNMA 3CBMA 4O6FA 5LSXA 3IHXA 5EX0A 2QPWA 4BUPA 5TH7A 2RFIA 4QENA 3QWPA 5AYFA 3M55A 3DALA 2BQZA 2R3AA 1ZKKA 4MI5A 3OOIA 3M56A 3CBOA 3PDNA 4MI0A 3M58A 4YPAA 5F6LA 3OS5A 4AU7A 4NJ5A 5JINA 3F9XA 5JHNA 3DB5A 5F6KC 5CCLA 1N6CA 3M5AA 4QEPA 2W5ZA 3VUZA 3F9WA 1ML9A 3KMJA 3OPEA 4J7IA 2JV0A 4C1QA 4J83A 3M59A 5CPRB 5ARGA 3MO0A 3MO5A 3VV0A 2G46A 4WUYA 3F9ZA 2O8JA 4E47A 1O9SA 3S7DA 5T0MA 3TG5A 5CCMA 1MVHA 4H12A 3MEKA
chains in the Genus database with same CATH superfamily
3RAYA 3RQ4A 4QEOA 3S7BA 4YPEA 4YNPA 4O30A 3M57A 4FMUA 5HI7A 2IGQA 5LSZA 3SWCA 4LDGA 4I51A 5TTFA 5KJLA 1N3JA 4NVQA 5EX3A 1MVXA 3RU0A 1PEGA 3M53A 5KJMA 3KMAA 4J7FA 5T5GA 5KJNA 1N6AA 5ARFA 1MT6A 3EP0A 4JDSA 5JJ0A 3QWWA 1XQHA 2W5YA 3QWVA 4JLGA 5F59A 3N71A 3S8PA 4Z4PA 4YNDA 3MO2A 5F5EA 3S7FA 1MUFA 3F9YA 4J8OA 3RJWA 4IJDA 5T0KA 1H3IA 3K5KA 3OXFA 4RZ0A 4IJ8A 3SW9A 3TG4A 5HQ8A 5EG2A 5JIYA 5TEGA 3OXGA 3S7JA 5KJKA 3CBPA 3OXLA 3RIBA 4YPUA 3HNAA 2F69A 3KMTA 3BO5A 3FPDA 3M54A 4YNMA 3CBMA 4O6FA 5LSXA 3IHXA 5EX0A 2QPWA 4BUPA 5TH7A 2RFIA 4QENA 3QWPA 5AYFA 3M55A 3DALA 2BQZA 2R3AA 1ZKKA 4MI5A 3OOIA 3M56A 3CBOA 3PDNA 4MI0A 3M58A 4YPAA 5F6LA 3OS5A 4AU7A 4NJ5A 5JINA 3F9XA 5JHNA 3DB5A 5F6KC 5CCLA 1N6CA 3M5AA 4QEPA 2W5ZA 3VUZA 3F9WA 1ML9A 3KMJA 3OPEA 4J7IA 2JV0A 4C1QA 4J83A 3M59A 5CPRB 5ARGA 3MO0A 3MO5A 3VV0A 2G46A 4WUYA 3F9ZA 2O8JA 4E47A 1O9SA 3S7DA 5T0MA 3TG5A 5CCMA 1MVHA 4H12A 3MEKA
chains in the Genus database with same CATH topology
3RAYA 3RQ4A 4QEOA 3S7BA 4YPEA 4YNPA 4O30A 3M57A 4FMUA 5HI7A 2IGQA 5LSZA 3SWCA 4LDGA 4I51A 5TTFA 5KJLA 1N3JA 4NVQA 5EX3A 1MVXA 3RU0A 1PEGA 3M53A 5KJMA 3KMAA 4J7FA 5T5GA 5KJNA 1N6AA 5ARFA 1MT6A 3EP0A 4JDSA 5JJ0A 3QWWA 1XQHA 2W5YA 3QWVA 4JLGA 5F59A 3N71A 3S8PA 4Z4PA 4YNDA 3MO2A 5F5EA 3S7FA 1MUFA 3F9YA 4J8OA 3RJWA 4IJDA 5T0KA 1H3IA 3K5KA 3OXFA 4RZ0A 4IJ8A 3SW9A 3TG4A 5HQ8A 5EG2A 5JIYA 5TEGA 3OXGA 3S7JA 5KJKA 3CBPA 3OXLA 3RIBA 4YPUA 3HNAA 2F69A 3KMTA 3BO5A 3FPDA 3M54A 4YNMA 3CBMA 4O6FA 5LSXA 3IHXA 5EX0A 2QPWA 4BUPA 5TH7A 2RFIA 4QENA 3QWPA 5AYFA 3M55A 3DALA 2BQZA 2R3AA 1ZKKA 4MI5A 3OOIA 3M56A 3CBOA 3PDNA 4MI0A 3M58A 4YPAA 5F6LA 3OS5A 4AU7A 4NJ5A 5JINA 3F9XA 5JHNA 3DB5A 5F6KC 5CCLA 1N6CA 3M5AA 4QEPA 2W5ZA 3VUZA 3F9WA 1ML9A 3KMJA 3OPEA 4J7IA 2JV0A 4C1QA 4J83A 3M59A 5CPRB 5ARGA 3MO0A 3MO5A 3VV0A 2G46A 4WUYA 3F9ZA 2O8JA 4E47A 1O9SA 3S7DA 5T0MA 3TG5A 5CCMA 1MVHA 4H12A 3MEKA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3RAY A;  3RQ4 A;  4QEO A;  3S7B A;  4YPE A;  4YNP A;  4O30 A;  3M57 A;  4FMU A;  5HI7 A;  2IGQ A;  5LSZ A;  3SWC A;  4LDG A;  4I51 A;  5TTF A;  5KJL A;  1N3J A;  4NVQ A;  5EX3 A;  1MVX A;  3RU0 A;  1PEG A;  3M53 A;  5KJM A;  3KMA A;  4J7F A;  5T5G A;  5KJN A;  1N6A A;  5ARF A;  1MT6 A;  3EP0 A;  4JDS A;  5JJ0 A;  3QWW A;  1XQH A;  2W5Y A;  3QWV A;  4JLG A;  5F59 A;  3N71 A;  3S8P A;  4Z4P A;  4YND A;  3MO2 A;  5F5E A;  3S7F A;  1MUF A;  3F9Y A;  4J8O A;  3RJW A;  4IJD A;  5T0K A;  1H3I A;  3K5K A;  3OXF A;  4RZ0 A;  4IJ8 A;  3SW9 A;  3TG4 A;  5HQ8 A;  5EG2 A;  5JIY A;  5TEG A;  3OXG A;  3S7J A;  5KJK A;  3CBP A;  3OXL A;  3RIB A;  4YPU A;  3HNA A;  2F69 A;  3KMT A;  3BO5 A;  3FPD A;  3M54 A;  4YNM A;  3CBM A;  4O6F A;  5LSX A;  3IHX A;  5EX0 A;  2QPW A;  4BUP A;  5TH7 A;  2RFI A;  4QEN A;  3QWP A;  5AYF A;  3M55 A;  3DAL A;  2BQZ A;  2R3A A;  1ZKK A;  4MI5 A;  3OOI A;  3M56 A;  3CBO A;  3PDN A;  4MI0 A;  3M58 A;  4YPA A;  5F6L A;  3OS5 A;  4AU7 A;  4NJ5 A;  5JIN A;  3F9X A;  5JHN A;  3DB5 A;  5F6K C;  5CCL A;  1N6C A;  3M5A A;  4QEP A;  2W5Z A;  3VUZ A;  3F9W A;  1ML9 A;  3KMJ A;  3OPE A;  4J7I A;  2JV0 A;  4C1Q A;  4J83 A;  3M59 A;  5CPR B;  5ARG A;  3MO0 A;  3MO5 A;  3VV0 A;  2G46 A;  4WUY A;  3F9Z A;  2O8J A;  4E47 A;  1O9S A;  3S7D A;  5T0M A;  3TG5 A;  5CCM A;  1MVH A;  4H12 A;  3MEK A; 
#chains in the Genus database with same CATH topology
 3RAY A;  3RQ4 A;  4QEO A;  3S7B A;  4YPE A;  4YNP A;  4O30 A;  3M57 A;  4FMU A;  5HI7 A;  2IGQ A;  5LSZ A;  3SWC A;  4LDG A;  4I51 A;  5TTF A;  5KJL A;  1N3J A;  4NVQ A;  5EX3 A;  1MVX A;  3RU0 A;  1PEG A;  3M53 A;  5KJM A;  3KMA A;  4J7F A;  5T5G A;  5KJN A;  1N6A A;  5ARF A;  1MT6 A;  3EP0 A;  4JDS A;  5JJ0 A;  3QWW A;  1XQH A;  2W5Y A;  3QWV A;  4JLG A;  5F59 A;  3N71 A;  3S8P A;  4Z4P A;  4YND A;  3MO2 A;  5F5E A;  3S7F A;  1MUF A;  3F9Y A;  4J8O A;  3RJW A;  4IJD A;  5T0K A;  1H3I A;  3K5K A;  3OXF A;  4RZ0 A;  4IJ8 A;  3SW9 A;  3TG4 A;  5HQ8 A;  5EG2 A;  5JIY A;  5TEG A;  3OXG A;  3S7J A;  5KJK A;  3CBP A;  3OXL A;  3RIB A;  4YPU A;  3HNA A;  2F69 A;  3KMT A;  3BO5 A;  3FPD A;  3M54 A;  4YNM A;  3CBM A;  4O6F A;  5LSX A;  3IHX A;  5EX0 A;  2QPW A;  4BUP A;  5TH7 A;  2RFI A;  4QEN A;  3QWP A;  5AYF A;  3M55 A;  3DAL A;  2BQZ A;  2R3A A;  1ZKK A;  4MI5 A;  3OOI A;  3M56 A;  3CBO A;  3PDN A;  4MI0 A;  3M58 A;  4YPA A;  5F6L A;  3OS5 A;  4AU7 A;  4NJ5 A;  5JIN A;  3F9X A;  5JHN A;  3DB5 A;  5F6K C;  5CCL A;  1N6C A;  3M5A A;  4QEP A;  2W5Z A;  3VUZ A;  3F9W A;  1ML9 A;  3KMJ A;  3OPE A;  4J7I A;  2JV0 A;  4C1Q A;  4J83 A;  3M59 A;  5CPR B;  5ARG A;  3MO0 A;  3MO5 A;  3VV0 A;  2G46 A;  4WUY A;  3F9Z A;  2O8J A;  4E47 A;  1O9S A;  3S7D A;  5T0M A;  3TG5 A;  5CCM A;  1MVH A;  4H12 A;  3MEK A; 
#chains in the Genus database with same CATH homology
 3RAY A;  3RQ4 A;  4QEO A;  3S7B A;  4YPE A;  4YNP A;  4O30 A;  3M57 A;  4FMU A;  5HI7 A;  2IGQ A;  5LSZ A;  3SWC A;  4LDG A;  4I51 A;  5TTF A;  5KJL A;  1N3J A;  4NVQ A;  5EX3 A;  1MVX A;  3RU0 A;  1PEG A;  3M53 A;  5KJM A;  3KMA A;  4J7F A;  5T5G A;  5KJN A;  1N6A A;  5ARF A;  1MT6 A;  3EP0 A;  4JDS A;  5JJ0 A;  3QWW A;  1XQH A;  2W5Y A;  3QWV A;  4JLG A;  5F59 A;  3N71 A;  3S8P A;  4Z4P A;  4YND A;  3MO2 A;  5F5E A;  3S7F A;  1MUF A;  3F9Y A;  4J8O A;  3RJW A;  4IJD A;  5T0K A;  1H3I A;  3K5K A;  3OXF A;  4RZ0 A;  4IJ8 A;  3SW9 A;  3TG4 A;  5HQ8 A;  5EG2 A;  5JIY A;  5TEG A;  3OXG A;  3S7J A;  5KJK A;  3CBP A;  3OXL A;  3RIB A;  4YPU A;  3HNA A;  2F69 A;  3KMT A;  3BO5 A;  3FPD A;  3M54 A;  4YNM A;  3CBM A;  4O6F A;  5LSX A;  3IHX A;  5EX0 A;  2QPW A;  4BUP A;  5TH7 A;  2RFI A;  4QEN A;  3QWP A;  5AYF A;  3M55 A;  3DAL A;  2BQZ A;  2R3A A;  1ZKK A;  4MI5 A;  3OOI A;  3M56 A;  3CBO A;  3PDN A;  4MI0 A;  3M58 A;  4YPA A;  5F6L A;  3OS5 A;  4AU7 A;  4NJ5 A;  5JIN A;  3F9X A;  5JHN A;  3DB5 A;  5F6K C;  5CCL A;  1N6C A;  3M5A A;  4QEP A;  2W5Z A;  3VUZ A;  3F9W A;  1ML9 A;  3KMJ A;  3OPE A;  4J7I A;  2JV0 A;  4C1Q A;  4J83 A;  3M59 A;  5CPR B;  5ARG A;  3MO0 A;  3MO5 A;  3VV0 A;  2G46 A;  4WUY A;  3F9Z A;  2O8J A;  4E47 A;  1O9S A;  3S7D A;  5T0M A;  3TG5 A;  5CCM A;  1MVH A;  4H12 A;  3MEK A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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