2O8JA

Human euchromatic histone methyltransferase 2
Total Genus 59
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
59
sequence length
262
structure length
254
Chain Sequence
KIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDYFTCQCGSEKCKHSAEA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural biology of human H3K9 methyltransferases
pubmed doi rcsb
molecule tags Transferase
source organism Homo sapiens
molecule keywords Histone-lysine N-methyltransferase, H3 lysine-9 specific 3
total genus 59
structure length 254
sequence length 262
chains with identical sequence B, C, D
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2006-12-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF05033 Pre-SET Pre-SET motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 2o8jA00
5F6LA 3OPEA 5F6KC 3RAYA 4C1QA 3QWVA 4FMUA 1N3JA 1O9SA 3S8PA 3FPDA 4O6FA 5CCMA 5T5GA 3VUZA 4I51A 1N6AA 4NVQA 5ARFA 3M58A 3OXLA 3QWWA 4Z4PA 4H12A 4YNPA 1MT6A 4YNDA 4YPUA 3DB5A 4J7IA 4AU7A 5TEGA 3SWCA 3QWPA 2G46A 4O30A 4MI5A 3F9XA 3EP0A 5HQ8A 3CBPA 5TH7A 1MVHA 5JINA 1MUFA 2R3AA 4JDSA 3CBMA 2F69A 4MI0A 3S7JA 4QENA 4J7FA 1ZKKA 3HNAA 5ARGA 3S7DA 3M56A 3MEKA 5LSXA 2RFIA 3M53A 3K5KA 3M55A 4YPEA 4QEOA 1H3IA 3S7FA 3BO5A 3OOIA 4J8OA 5KJMA 3VV0A 1N6CA 5EX0A 4J83A 5EX3A 5F5EA 3M59A 5TTFA 3PDNA 5AYFA 3OXFA 5LSZA 3KMAA 3DALA 5T0MA 3RJWA 2W5YA 4WUYA 3RQ4A 3F9WA 2QPWA 5CCLA 5HI7A 4RZ0A 3OXGA 4LDGA 5KJKA 3TG4A 2BQZA 2W5ZA 3IHXA 3KMTA 5KJLA 3MO2A 4IJDA 4JLGA 3TG5A 5CPRB 4E47A 5T0KA 3M54A 4YPAA 3SW9A 1XQHA 4NJ5A 3F9ZA 1MVXA 3MO5A 3F9YA 3N71A 1PEGA 3M57A 4YNMA 3OS5A 1ML9A 2JV0A 5JIYA 3RIBA 2O8JA 5JHNA 2IGQA 3MO0A 4BUPA 5EG2A 5F59A 3KMJA 5KJNA 4QEPA 3S7BA 3CBOA 4IJ8A 3M5AA 3RU0A 5JJ0A
chains in the Genus database with same CATH superfamily
5F6LA 3OPEA 5F6KC 3RAYA 4C1QA 3QWVA 4FMUA 1N3JA 1O9SA 3S8PA 3FPDA 4O6FA 5CCMA 5T5GA 3VUZA 4I51A 1N6AA 4NVQA 5ARFA 3M58A 3OXLA 3QWWA 4Z4PA 4H12A 4YNPA 1MT6A 4YNDA 4YPUA 3DB5A 4J7IA 4AU7A 5TEGA 3SWCA 3QWPA 2G46A 4O30A 4MI5A 3F9XA 3EP0A 5HQ8A 3CBPA 5TH7A 1MVHA 5JINA 1MUFA 2R3AA 4JDSA 3CBMA 2F69A 4MI0A 3S7JA 4QENA 4J7FA 1ZKKA 3HNAA 5ARGA 3S7DA 3M56A 3MEKA 5LSXA 2RFIA 3M53A 3K5KA 3M55A 4YPEA 4QEOA 1H3IA 3S7FA 3BO5A 3OOIA 4J8OA 5KJMA 3VV0A 1N6CA 5EX0A 4J83A 5EX3A 5F5EA 3M59A 5TTFA 3PDNA 5AYFA 3OXFA 5LSZA 3KMAA 3DALA 5T0MA 3RJWA 2W5YA 4WUYA 3RQ4A 3F9WA 2QPWA 5CCLA 5HI7A 4RZ0A 3OXGA 4LDGA 5KJKA 3TG4A 2BQZA 2W5ZA 3IHXA 3KMTA 5KJLA 3MO2A 4IJDA 4JLGA 3TG5A 5CPRB 4E47A 5T0KA 3M54A 4YPAA 3SW9A 1XQHA 4NJ5A 3F9ZA 1MVXA 3MO5A 3F9YA 3N71A 1PEGA 3M57A 4YNMA 3OS5A 1ML9A 2JV0A 5JIYA 3RIBA 2O8JA 5JHNA 2IGQA 3MO0A 4BUPA 5EG2A 5F59A 3KMJA 5KJNA 4QEPA 3S7BA 3CBOA 4IJ8A 3M5AA 3RU0A 5JJ0A
chains in the Genus database with same CATH topology
5F6LA 3OPEA 5F6KC 3RAYA 4C1QA 3QWVA 4FMUA 1N3JA 1O9SA 3S8PA 3FPDA 4O6FA 5CCMA 5T5GA 3VUZA 4I51A 1N6AA 4NVQA 5ARFA 3M58A 3OXLA 3QWWA 4Z4PA 4H12A 4YNPA 1MT6A 4YNDA 4YPUA 3DB5A 4J7IA 4AU7A 5TEGA 3SWCA 3QWPA 2G46A 4O30A 4MI5A 3F9XA 3EP0A 5HQ8A 3CBPA 5TH7A 1MVHA 5JINA 1MUFA 2R3AA 4JDSA 3CBMA 2F69A 4MI0A 3S7JA 4QENA 4J7FA 1ZKKA 3HNAA 5ARGA 3S7DA 3M56A 3MEKA 5LSXA 2RFIA 3M53A 3K5KA 3M55A 4YPEA 4QEOA 1H3IA 3S7FA 3BO5A 3OOIA 4J8OA 5KJMA 3VV0A 1N6CA 5EX0A 4J83A 5EX3A 5F5EA 3M59A 5TTFA 3PDNA 5AYFA 3OXFA 5LSZA 3KMAA 3DALA 5T0MA 3RJWA 2W5YA 4WUYA 3RQ4A 3F9WA 2QPWA 5CCLA 5HI7A 4RZ0A 3OXGA 4LDGA 5KJKA 3TG4A 2BQZA 2W5ZA 3IHXA 3KMTA 5KJLA 3MO2A 4IJDA 4JLGA 3TG5A 5CPRB 4E47A 5T0KA 3M54A 4YPAA 3SW9A 1XQHA 4NJ5A 3F9ZA 1MVXA 3MO5A 3F9YA 3N71A 1PEGA 3M57A 4YNMA 3OS5A 1ML9A 2JV0A 5JIYA 3RIBA 2O8JA 5JHNA 2IGQA 3MO0A 4BUPA 5EG2A 5F59A 3KMJA 5KJNA 4QEPA 3S7BA 3CBOA 4IJ8A 3M5AA 3RU0A 5JJ0A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5F6L A;  3OPE A;  5F6K C;  3RAY A;  4C1Q A;  3QWV A;  4FMU A;  1N3J A;  1O9S A;  3S8P A;  3FPD A;  4O6F A;  5CCM A;  5T5G A;  3VUZ A;  4I51 A;  1N6A A;  4NVQ A;  5ARF A;  3M58 A;  3OXL A;  3QWW A;  4Z4P A;  4H12 A;  4YNP A;  1MT6 A;  4YND A;  4YPU A;  3DB5 A;  4J7I A;  4AU7 A;  5TEG A;  3SWC A;  3QWP A;  2G46 A;  4O30 A;  4MI5 A;  3F9X A;  3EP0 A;  5HQ8 A;  3CBP A;  5TH7 A;  1MVH A;  5JIN A;  1MUF A;  2R3A A;  4JDS A;  3CBM A;  2F69 A;  4MI0 A;  3S7J A;  4QEN A;  4J7F A;  1ZKK A;  3HNA A;  5ARG A;  3S7D A;  3M56 A;  3MEK A;  5LSX A;  2RFI A;  3M53 A;  3K5K A;  3M55 A;  4YPE A;  4QEO A;  1H3I A;  3S7F A;  3BO5 A;  3OOI A;  4J8O A;  5KJM A;  3VV0 A;  1N6C A;  5EX0 A;  4J83 A;  5EX3 A;  5F5E A;  3M59 A;  5TTF A;  3PDN A;  5AYF A;  3OXF A;  5LSZ A;  3KMA A;  3DAL A;  5T0M A;  3RJW A;  2W5Y A;  4WUY A;  3RQ4 A;  3F9W A;  2QPW A;  5CCL A;  5HI7 A;  4RZ0 A;  3OXG A;  4LDG A;  5KJK A;  3TG4 A;  2BQZ A;  2W5Z A;  3IHX A;  3KMT A;  5KJL A;  3MO2 A;  4IJD A;  4JLG A;  3TG5 A;  5CPR B;  4E47 A;  5T0K A;  3M54 A;  4YPA A;  3SW9 A;  1XQH A;  4NJ5 A;  3F9Z A;  1MVX A;  3MO5 A;  3F9Y A;  3N71 A;  1PEG A;  3M57 A;  4YNM A;  3OS5 A;  1ML9 A;  2JV0 A;  5JIY A;  3RIB A;  2O8J A;  5JHN A;  2IGQ A;  3MO0 A;  4BUP A;  5EG2 A;  5F59 A;  3KMJ A;  5KJN A;  4QEP A;  3S7B A;  3CBO A;  4IJ8 A;  3M5A A;  3RU0 A;  5JJ0 A; 
#chains in the Genus database with same CATH topology
 5F6L A;  3OPE A;  5F6K C;  3RAY A;  4C1Q A;  3QWV A;  4FMU A;  1N3J A;  1O9S A;  3S8P A;  3FPD A;  4O6F A;  5CCM A;  5T5G A;  3VUZ A;  4I51 A;  1N6A A;  4NVQ A;  5ARF A;  3M58 A;  3OXL A;  3QWW A;  4Z4P A;  4H12 A;  4YNP A;  1MT6 A;  4YND A;  4YPU A;  3DB5 A;  4J7I A;  4AU7 A;  5TEG A;  3SWC A;  3QWP A;  2G46 A;  4O30 A;  4MI5 A;  3F9X A;  3EP0 A;  5HQ8 A;  3CBP A;  5TH7 A;  1MVH A;  5JIN A;  1MUF A;  2R3A A;  4JDS A;  3CBM A;  2F69 A;  4MI0 A;  3S7J A;  4QEN A;  4J7F A;  1ZKK A;  3HNA A;  5ARG A;  3S7D A;  3M56 A;  3MEK A;  5LSX A;  2RFI A;  3M53 A;  3K5K A;  3M55 A;  4YPE A;  4QEO A;  1H3I A;  3S7F A;  3BO5 A;  3OOI A;  4J8O A;  5KJM A;  3VV0 A;  1N6C A;  5EX0 A;  4J83 A;  5EX3 A;  5F5E A;  3M59 A;  5TTF A;  3PDN A;  5AYF A;  3OXF A;  5LSZ A;  3KMA A;  3DAL A;  5T0M A;  3RJW A;  2W5Y A;  4WUY A;  3RQ4 A;  3F9W A;  2QPW A;  5CCL A;  5HI7 A;  4RZ0 A;  3OXG A;  4LDG A;  5KJK A;  3TG4 A;  2BQZ A;  2W5Z A;  3IHX A;  3KMT A;  5KJL A;  3MO2 A;  4IJD A;  4JLG A;  3TG5 A;  5CPR B;  4E47 A;  5T0K A;  3M54 A;  4YPA A;  3SW9 A;  1XQH A;  4NJ5 A;  3F9Z A;  1MVX A;  3MO5 A;  3F9Y A;  3N71 A;  1PEG A;  3M57 A;  4YNM A;  3OS5 A;  1ML9 A;  2JV0 A;  5JIY A;  3RIB A;  2O8J A;  5JHN A;  2IGQ A;  3MO0 A;  4BUP A;  5EG2 A;  5F59 A;  3KMJ A;  5KJN A;  4QEP A;  3S7B A;  3CBO A;  4IJ8 A;  3M5A A;  3RU0 A;  5JJ0 A; 
#chains in the Genus database with same CATH homology
 5F6L A;  3OPE A;  5F6K C;  3RAY A;  4C1Q A;  3QWV A;  4FMU A;  1N3J A;  1O9S A;  3S8P A;  3FPD A;  4O6F A;  5CCM A;  5T5G A;  3VUZ A;  4I51 A;  1N6A A;  4NVQ A;  5ARF A;  3M58 A;  3OXL A;  3QWW A;  4Z4P A;  4H12 A;  4YNP A;  1MT6 A;  4YND A;  4YPU A;  3DB5 A;  4J7I A;  4AU7 A;  5TEG A;  3SWC A;  3QWP A;  2G46 A;  4O30 A;  4MI5 A;  3F9X A;  3EP0 A;  5HQ8 A;  3CBP A;  5TH7 A;  1MVH A;  5JIN A;  1MUF A;  2R3A A;  4JDS A;  3CBM A;  2F69 A;  4MI0 A;  3S7J A;  4QEN A;  4J7F A;  1ZKK A;  3HNA A;  5ARG A;  3S7D A;  3M56 A;  3MEK A;  5LSX A;  2RFI A;  3M53 A;  3K5K A;  3M55 A;  4YPE A;  4QEO A;  1H3I A;  3S7F A;  3BO5 A;  3OOI A;  4J8O A;  5KJM A;  3VV0 A;  1N6C A;  5EX0 A;  4J83 A;  5EX3 A;  5F5E A;  3M59 A;  5TTF A;  3PDN A;  5AYF A;  3OXF A;  5LSZ A;  3KMA A;  3DAL A;  5T0M A;  3RJW A;  2W5Y A;  4WUY A;  3RQ4 A;  3F9W A;  2QPW A;  5CCL A;  5HI7 A;  4RZ0 A;  3OXG A;  4LDG A;  5KJK A;  3TG4 A;  2BQZ A;  2W5Z A;  3IHX A;  3KMT A;  5KJL A;  3MO2 A;  4IJD A;  4JLG A;  3TG5 A;  5CPR B;  4E47 A;  5T0K A;  3M54 A;  4YPA A;  3SW9 A;  1XQH A;  4NJ5 A;  3F9Z A;  1MVX A;  3MO5 A;  3F9Y A;  3N71 A;  1PEG A;  3M57 A;  4YNM A;  3OS5 A;  1ML9 A;  2JV0 A;  5JIY A;  3RIB A;  2O8J A;  5JHN A;  2IGQ A;  3MO0 A;  4BUP A;  5EG2 A;  5F59 A;  3KMJ A;  5KJN A;  4QEP A;  3S7B A;  3CBO A;  4IJ8 A;  3M5A A;  3RU0 A;  5JJ0 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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