2O8JA

Human euchromatic histone methyltransferase 2
Total Genus 59
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
59
sequence length
262
structure length
254
Chain Sequence
KIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDYFTCQCGSEKCKHSAEA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural biology of human H3K9 methyltransferases
pubmed doi rcsb
source organism Homo sapiens
molecule tags Transferase
molecule keywords Histone-lysine N-methyltransferase, H3 lysine-9 specific 3
total genus 59
structure length 254
sequence length 262
chains with identical sequence B, C, D
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2006-12-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF05033 Pre-SET Pre-SET motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 2o8jA00
5JJ0A 1MVHA 3KMAA 3MO5A 2W5ZA 3HNAA 4O6FA 5F6LA 2RFIA 4I51A 3S8PA 3S7FA 4YNDA 3F9YA 3KMJA 4MI5A 5T5GA 1MVXA 5ARGA 4YNMA 4YPUA 5KJMA 3CBMA 4Z4PA 5T0KA 3MO0A 3N71A 4JDSA 5KJNA 2BQZA 2JV0A 3F9WA 5LSXA 3RIBA 3OPEA 3S7JA 3MO2A 5KJLA 3OXFA 1ML9A 1N3JA 3OXLA 4FMUA 3OOIA 3F9XA 4J7FA 3VV0A 5TEGA 3DB5A 4YPEA 5CPRB 4QEPA 1H3IA 3QWVA 2W5YA 3MEKA 5F5EA 5EX0A 5HI7A 3IHXA 3RJWA 3S7DA 3CBOA 4E47A 5EX3A 5JIYA 4NVQA 4J8OA 5ARFA 4BUPA 4H12A 3QWPA 3S7BA 1MT6A 3M59A 1MUFA 5TTFA 3TG5A 3K5KA 3M53A 1PEGA 3M54A 5CCMA 3RAYA 2QPWA 3RU0A 1ZKKA 3BO5A 3KMTA 3M57A 5KJKA 1N6AA 4JLGA 3TG4A 5TH7A 5AYFA 4IJ8A 4IJDA 3FPDA 5LSZA 3M56A 3SWCA 4RZ0A 1XQHA 5CCLA 3PDNA 5HQ8A 3OXGA 4LDGA 5F6KC 3DALA 4QENA 3F9ZA 4O30A 4AU7A 4C1QA 3M55A 5JHNA 5T0MA 3CBPA 1N6CA 3M58A 2G46A 3RQ4A 4MI0A 2O8JA 5EG2A 5JINA 3M5AA 3SW9A 4QEOA 3VUZA 4YPAA 2R3AA 3QWWA 4NJ5A 3OS5A 3EP0A 2F69A 4WUYA 4J7IA 4YNPA 5F59A 2IGQA 4J83A 1O9SA
chains in the Genus database with same CATH superfamily
5JJ0A 1MVHA 3KMAA 3MO5A 2W5ZA 3HNAA 4O6FA 5F6LA 2RFIA 4I51A 3S8PA 3S7FA 4YNDA 3F9YA 3KMJA 4MI5A 5T5GA 1MVXA 5ARGA 4YNMA 4YPUA 5KJMA 3CBMA 4Z4PA 5T0KA 3MO0A 3N71A 4JDSA 5KJNA 2BQZA 2JV0A 3F9WA 5LSXA 3RIBA 3OPEA 3S7JA 3MO2A 5KJLA 3OXFA 1ML9A 1N3JA 3OXLA 4FMUA 3OOIA 3F9XA 4J7FA 3VV0A 5TEGA 3DB5A 4YPEA 5CPRB 4QEPA 1H3IA 3QWVA 2W5YA 3MEKA 5F5EA 5EX0A 5HI7A 3IHXA 3RJWA 3S7DA 3CBOA 4E47A 5EX3A 5JIYA 4NVQA 4J8OA 5ARFA 4BUPA 4H12A 3QWPA 3S7BA 1MT6A 3M59A 1MUFA 5TTFA 3TG5A 3K5KA 3M53A 1PEGA 3M54A 5CCMA 3RAYA 2QPWA 3RU0A 1ZKKA 3BO5A 3KMTA 3M57A 5KJKA 1N6AA 4JLGA 3TG4A 5TH7A 5AYFA 4IJ8A 4IJDA 3FPDA 5LSZA 3M56A 3SWCA 4RZ0A 1XQHA 5CCLA 3PDNA 5HQ8A 3OXGA 4LDGA 5F6KC 3DALA 4QENA 3F9ZA 4O30A 4AU7A 4C1QA 3M55A 5JHNA 5T0MA 3CBPA 1N6CA 3M58A 2G46A 3RQ4A 4MI0A 2O8JA 5EG2A 5JINA 3M5AA 3SW9A 4QEOA 3VUZA 4YPAA 2R3AA 3QWWA 4NJ5A 3OS5A 3EP0A 2F69A 4WUYA 4J7IA 4YNPA 5F59A 2IGQA 4J83A 1O9SA
chains in the Genus database with same CATH topology
5JJ0A 1MVHA 3KMAA 3MO5A 2W5ZA 3HNAA 4O6FA 5F6LA 2RFIA 4I51A 3S8PA 3S7FA 4YNDA 3F9YA 3KMJA 4MI5A 5T5GA 1MVXA 5ARGA 4YNMA 4YPUA 5KJMA 3CBMA 4Z4PA 5T0KA 3MO0A 3N71A 4JDSA 5KJNA 2BQZA 2JV0A 3F9WA 5LSXA 3RIBA 3OPEA 3S7JA 3MO2A 5KJLA 3OXFA 1ML9A 1N3JA 3OXLA 4FMUA 3OOIA 3F9XA 4J7FA 3VV0A 5TEGA 3DB5A 4YPEA 5CPRB 4QEPA 1H3IA 3QWVA 2W5YA 3MEKA 5F5EA 5EX0A 5HI7A 3IHXA 3RJWA 3S7DA 3CBOA 4E47A 5EX3A 5JIYA 4NVQA 4J8OA 5ARFA 4BUPA 4H12A 3QWPA 3S7BA 1MT6A 3M59A 1MUFA 5TTFA 3TG5A 3K5KA 3M53A 1PEGA 3M54A 5CCMA 3RAYA 2QPWA 3RU0A 1ZKKA 3BO5A 3KMTA 3M57A 5KJKA 1N6AA 4JLGA 3TG4A 5TH7A 5AYFA 4IJ8A 4IJDA 3FPDA 5LSZA 3M56A 3SWCA 4RZ0A 1XQHA 5CCLA 3PDNA 5HQ8A 3OXGA 4LDGA 5F6KC 3DALA 4QENA 3F9ZA 4O30A 4AU7A 4C1QA 3M55A 5JHNA 5T0MA 3CBPA 1N6CA 3M58A 2G46A 3RQ4A 4MI0A 2O8JA 5EG2A 5JINA 3M5AA 3SW9A 4QEOA 3VUZA 4YPAA 2R3AA 3QWWA 4NJ5A 3OS5A 3EP0A 2F69A 4WUYA 4J7IA 4YNPA 5F59A 2IGQA 4J83A 1O9SA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5JJ0 A;  1MVH A;  3KMA A;  3MO5 A;  2W5Z A;  3HNA A;  4O6F A;  5F6L A;  2RFI A;  4I51 A;  3S8P A;  3S7F A;  4YND A;  3F9Y A;  3KMJ A;  4MI5 A;  5T5G A;  1MVX A;  5ARG A;  4YNM A;  4YPU A;  5KJM A;  3CBM A;  4Z4P A;  5T0K A;  3MO0 A;  3N71 A;  4JDS A;  5KJN A;  2BQZ A;  2JV0 A;  3F9W A;  5LSX A;  3RIB A;  3OPE A;  3S7J A;  3MO2 A;  5KJL A;  3OXF A;  1ML9 A;  1N3J A;  3OXL A;  4FMU A;  3OOI A;  3F9X A;  4J7F A;  3VV0 A;  5TEG A;  3DB5 A;  4YPE A;  5CPR B;  4QEP A;  1H3I A;  3QWV A;  2W5Y A;  3MEK A;  5F5E A;  5EX0 A;  5HI7 A;  3IHX A;  3RJW A;  3S7D A;  3CBO A;  4E47 A;  5EX3 A;  5JIY A;  4NVQ A;  4J8O A;  5ARF A;  4BUP A;  4H12 A;  3QWP A;  3S7B A;  1MT6 A;  3M59 A;  1MUF A;  5TTF A;  3TG5 A;  3K5K A;  3M53 A;  1PEG A;  3M54 A;  5CCM A;  3RAY A;  2QPW A;  3RU0 A;  1ZKK A;  3BO5 A;  3KMT A;  3M57 A;  5KJK A;  1N6A A;  4JLG A;  3TG4 A;  5TH7 A;  5AYF A;  4IJ8 A;  4IJD A;  3FPD A;  5LSZ A;  3M56 A;  3SWC A;  4RZ0 A;  1XQH A;  5CCL A;  3PDN A;  5HQ8 A;  3OXG A;  4LDG A;  5F6K C;  3DAL A;  4QEN A;  3F9Z A;  4O30 A;  4AU7 A;  4C1Q A;  3M55 A;  5JHN A;  5T0M A;  3CBP A;  1N6C A;  3M58 A;  2G46 A;  3RQ4 A;  4MI0 A;  2O8J A;  5EG2 A;  5JIN A;  3M5A A;  3SW9 A;  4QEO A;  3VUZ A;  4YPA A;  2R3A A;  3QWW A;  4NJ5 A;  3OS5 A;  3EP0 A;  2F69 A;  4WUY A;  4J7I A;  4YNP A;  5F59 A;  2IGQ A;  4J83 A;  1O9S A; 
#chains in the Genus database with same CATH topology
 5JJ0 A;  1MVH A;  3KMA A;  3MO5 A;  2W5Z A;  3HNA A;  4O6F A;  5F6L A;  2RFI A;  4I51 A;  3S8P A;  3S7F A;  4YND A;  3F9Y A;  3KMJ A;  4MI5 A;  5T5G A;  1MVX A;  5ARG A;  4YNM A;  4YPU A;  5KJM A;  3CBM A;  4Z4P A;  5T0K A;  3MO0 A;  3N71 A;  4JDS A;  5KJN A;  2BQZ A;  2JV0 A;  3F9W A;  5LSX A;  3RIB A;  3OPE A;  3S7J A;  3MO2 A;  5KJL A;  3OXF A;  1ML9 A;  1N3J A;  3OXL A;  4FMU A;  3OOI A;  3F9X A;  4J7F A;  3VV0 A;  5TEG A;  3DB5 A;  4YPE A;  5CPR B;  4QEP A;  1H3I A;  3QWV A;  2W5Y A;  3MEK A;  5F5E A;  5EX0 A;  5HI7 A;  3IHX A;  3RJW A;  3S7D A;  3CBO A;  4E47 A;  5EX3 A;  5JIY A;  4NVQ A;  4J8O A;  5ARF A;  4BUP A;  4H12 A;  3QWP A;  3S7B A;  1MT6 A;  3M59 A;  1MUF A;  5TTF A;  3TG5 A;  3K5K A;  3M53 A;  1PEG A;  3M54 A;  5CCM A;  3RAY A;  2QPW A;  3RU0 A;  1ZKK A;  3BO5 A;  3KMT A;  3M57 A;  5KJK A;  1N6A A;  4JLG A;  3TG4 A;  5TH7 A;  5AYF A;  4IJ8 A;  4IJD A;  3FPD A;  5LSZ A;  3M56 A;  3SWC A;  4RZ0 A;  1XQH A;  5CCL A;  3PDN A;  5HQ8 A;  3OXG A;  4LDG A;  5F6K C;  3DAL A;  4QEN A;  3F9Z A;  4O30 A;  4AU7 A;  4C1Q A;  3M55 A;  5JHN A;  5T0M A;  3CBP A;  1N6C A;  3M58 A;  2G46 A;  3RQ4 A;  4MI0 A;  2O8J A;  5EG2 A;  5JIN A;  3M5A A;  3SW9 A;  4QEO A;  3VUZ A;  4YPA A;  2R3A A;  3QWW A;  4NJ5 A;  3OS5 A;  3EP0 A;  2F69 A;  4WUY A;  4J7I A;  4YNP A;  5F59 A;  2IGQ A;  4J83 A;  1O9S A; 
#chains in the Genus database with same CATH homology
 5JJ0 A;  1MVH A;  3KMA A;  3MO5 A;  2W5Z A;  3HNA A;  4O6F A;  5F6L A;  2RFI A;  4I51 A;  3S8P A;  3S7F A;  4YND A;  3F9Y A;  3KMJ A;  4MI5 A;  5T5G A;  1MVX A;  5ARG A;  4YNM A;  4YPU A;  5KJM A;  3CBM A;  4Z4P A;  5T0K A;  3MO0 A;  3N71 A;  4JDS A;  5KJN A;  2BQZ A;  2JV0 A;  3F9W A;  5LSX A;  3RIB A;  3OPE A;  3S7J A;  3MO2 A;  5KJL A;  3OXF A;  1ML9 A;  1N3J A;  3OXL A;  4FMU A;  3OOI A;  3F9X A;  4J7F A;  3VV0 A;  5TEG A;  3DB5 A;  4YPE A;  5CPR B;  4QEP A;  1H3I A;  3QWV A;  2W5Y A;  3MEK A;  5F5E A;  5EX0 A;  5HI7 A;  3IHX A;  3RJW A;  3S7D A;  3CBO A;  4E47 A;  5EX3 A;  5JIY A;  4NVQ A;  4J8O A;  5ARF A;  4BUP A;  4H12 A;  3QWP A;  3S7B A;  1MT6 A;  3M59 A;  1MUF A;  5TTF A;  3TG5 A;  3K5K A;  3M53 A;  1PEG A;  3M54 A;  5CCM A;  3RAY A;  2QPW A;  3RU0 A;  1ZKK A;  3BO5 A;  3KMT A;  3M57 A;  5KJK A;  1N6A A;  4JLG A;  3TG4 A;  5TH7 A;  5AYF A;  4IJ8 A;  4IJD A;  3FPD A;  5LSZ A;  3M56 A;  3SWC A;  4RZ0 A;  1XQH A;  5CCL A;  3PDN A;  5HQ8 A;  3OXG A;  4LDG A;  5F6K C;  3DAL A;  4QEN A;  3F9Z A;  4O30 A;  4AU7 A;  4C1Q A;  3M55 A;  5JHN A;  5T0M A;  3CBP A;  1N6C A;  3M58 A;  2G46 A;  3RQ4 A;  4MI0 A;  2O8J A;  5EG2 A;  5JIN A;  3M5A A;  3SW9 A;  4QEO A;  3VUZ A;  4YPA A;  2R3A A;  3QWW A;  4NJ5 A;  3OS5 A;  3EP0 A;  2F69 A;  4WUY A;  4J7I A;  4YNP A;  5F59 A;  2IGQ A;  4J83 A;  1O9S A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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