2O8JA

Human euchromatic histone methyltransferase 2
Total Genus 59
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
59
sequence length
262
structure length
254
Chain Sequence
KIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDYFTCQCGSEKCKHSAEA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Transferase
molecule keywords Histone-lysine N-methyltransferase, H3 lysine-9 specific 3
publication title Structural biology of human H3K9 methyltransferases
pubmed doi rcsb
source organism Homo sapiens
total genus 59
structure length 254
sequence length 262
chains with identical sequence B, C, D
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2006-12-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF05033 Pre-SET Pre-SET motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 2o8jA00
3M55A 3OS5A 3OOIA 4O6FA 3OXLA 1MT6A 3QWVA 3MO5A 2G46A 3MO0A 3OXFA 2F69A 3S7BA 4E47A 3F9WA 2JV0A 4MI5A 3S7FA 5JIYA 3FPDA 5HI7A 4YPEA 4H12A 4J8OA 5EX3A 5CCMA 4IJDA 5CCLA 4J7IA 3RJWA 5JHNA 5TEGA 4QEOA 2BQZA 3KMJA 4FMUA 3F9YA 3F9ZA 5F6LA 4YNMA 3TG4A 3S7JA 5JINA 4Z4PA 5ARFA 5KJNA 3DALA 1MVXA 5CPRB 4C1QA 3RU0A 4J83A 3MEKA 4YNPA 3DB5A 3MO2A 4QENA 5KJLA 3M53A 2R3AA 2IGQA 4IJ8A 4RZ0A 4WUYA 3RQ4A 3K5KA 5T0MA 5TH7A 3F9XA 4J7FA 1H3IA 1XQHA 5F5EA 4O30A 3QWWA 3M56A 3M57A 5T0KA 2W5ZA 3SWCA 3SW9A 3S7DA 5AYFA 3TG5A 4YPUA 5HQ8A 2O8JA 1MUFA 3M54A 4NJ5A 5T5GA 4BUPA 4JLGA 3IHXA 3CBPA 3PDNA 5F59A 5KJMA 1MVHA 3VUZA 3HNAA 4I51A 3EP0A 1O9SA 2RFIA 5EX0A 1N6CA 1N6AA 3RIBA 4AU7A 5KJKA 3KMTA 5F6KC 5JJ0A 3RAYA 4MI0A 3CBMA 4JDSA 5LSZA 3VV0A 3KMAA 4YPAA 3BO5A 5ARGA 4NVQA 3N71A 1N3JA 4YNDA 5TTFA 3S8PA 3OXGA 4QEPA 1ZKKA 5LSXA 3M58A 4LDGA 2QPWA 1PEGA 2W5YA 3CBOA 3M5AA 3OPEA 3M59A 3QWPA 1ML9A 5EG2A
chains in the Genus database with same CATH superfamily
3M55A 3OS5A 3OOIA 4O6FA 3OXLA 1MT6A 3QWVA 3MO5A 2G46A 3MO0A 3OXFA 2F69A 3S7BA 4E47A 3F9WA 2JV0A 4MI5A 3S7FA 5JIYA 3FPDA 5HI7A 4YPEA 4H12A 4J8OA 5EX3A 5CCMA 4IJDA 5CCLA 4J7IA 3RJWA 5JHNA 5TEGA 4QEOA 2BQZA 3KMJA 4FMUA 3F9YA 3F9ZA 5F6LA 4YNMA 3TG4A 3S7JA 5JINA 4Z4PA 5ARFA 5KJNA 3DALA 1MVXA 5CPRB 4C1QA 3RU0A 4J83A 3MEKA 4YNPA 3DB5A 3MO2A 4QENA 5KJLA 3M53A 2R3AA 2IGQA 4IJ8A 4RZ0A 4WUYA 3RQ4A 3K5KA 5T0MA 5TH7A 3F9XA 4J7FA 1H3IA 1XQHA 5F5EA 4O30A 3QWWA 3M56A 3M57A 5T0KA 2W5ZA 3SWCA 3SW9A 3S7DA 5AYFA 3TG5A 4YPUA 5HQ8A 2O8JA 1MUFA 3M54A 4NJ5A 5T5GA 4BUPA 4JLGA 3IHXA 3CBPA 3PDNA 5F59A 5KJMA 1MVHA 3VUZA 3HNAA 4I51A 3EP0A 1O9SA 2RFIA 5EX0A 1N6CA 1N6AA 3RIBA 4AU7A 5KJKA 3KMTA 5F6KC 5JJ0A 3RAYA 4MI0A 3CBMA 4JDSA 5LSZA 3VV0A 3KMAA 4YPAA 3BO5A 5ARGA 4NVQA 3N71A 1N3JA 4YNDA 5TTFA 3S8PA 3OXGA 4QEPA 1ZKKA 5LSXA 3M58A 4LDGA 2QPWA 1PEGA 2W5YA 3CBOA 3M5AA 3OPEA 3M59A 3QWPA 1ML9A 5EG2A
chains in the Genus database with same CATH topology
3M55A 3OS5A 3OOIA 4O6FA 3OXLA 1MT6A 3QWVA 3MO5A 2G46A 3MO0A 3OXFA 2F69A 3S7BA 4E47A 3F9WA 2JV0A 4MI5A 3S7FA 5JIYA 3FPDA 5HI7A 4YPEA 4H12A 4J8OA 5EX3A 5CCMA 4IJDA 5CCLA 4J7IA 3RJWA 5JHNA 5TEGA 4QEOA 2BQZA 3KMJA 4FMUA 3F9YA 3F9ZA 5F6LA 4YNMA 3TG4A 3S7JA 5JINA 4Z4PA 5ARFA 5KJNA 3DALA 1MVXA 5CPRB 4C1QA 3RU0A 4J83A 3MEKA 4YNPA 3DB5A 3MO2A 4QENA 5KJLA 3M53A 2R3AA 2IGQA 4IJ8A 4RZ0A 4WUYA 3RQ4A 3K5KA 5T0MA 5TH7A 3F9XA 4J7FA 1H3IA 1XQHA 5F5EA 4O30A 3QWWA 3M56A 3M57A 5T0KA 2W5ZA 3SWCA 3SW9A 3S7DA 5AYFA 3TG5A 4YPUA 5HQ8A 2O8JA 1MUFA 3M54A 4NJ5A 5T5GA 4BUPA 4JLGA 3IHXA 3CBPA 3PDNA 5F59A 5KJMA 1MVHA 3VUZA 3HNAA 4I51A 3EP0A 1O9SA 2RFIA 5EX0A 1N6CA 1N6AA 3RIBA 4AU7A 5KJKA 3KMTA 5F6KC 5JJ0A 3RAYA 4MI0A 3CBMA 4JDSA 5LSZA 3VV0A 3KMAA 4YPAA 3BO5A 5ARGA 4NVQA 3N71A 1N3JA 4YNDA 5TTFA 3S8PA 3OXGA 4QEPA 1ZKKA 5LSXA 3M58A 4LDGA 2QPWA 1PEGA 2W5YA 3CBOA 3M5AA 3OPEA 3M59A 3QWPA 1ML9A 5EG2A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3M55 A;  3OS5 A;  3OOI A;  4O6F A;  3OXL A;  1MT6 A;  3QWV A;  3MO5 A;  2G46 A;  3MO0 A;  3OXF A;  2F69 A;  3S7B A;  4E47 A;  3F9W A;  2JV0 A;  4MI5 A;  3S7F A;  5JIY A;  3FPD A;  5HI7 A;  4YPE A;  4H12 A;  4J8O A;  5EX3 A;  5CCM A;  4IJD A;  5CCL A;  4J7I A;  3RJW A;  5JHN A;  5TEG A;  4QEO A;  2BQZ A;  3KMJ A;  4FMU A;  3F9Y A;  3F9Z A;  5F6L A;  4YNM A;  3TG4 A;  3S7J A;  5JIN A;  4Z4P A;  5ARF A;  5KJN A;  3DAL A;  1MVX A;  5CPR B;  4C1Q A;  3RU0 A;  4J83 A;  3MEK A;  4YNP A;  3DB5 A;  3MO2 A;  4QEN A;  5KJL A;  3M53 A;  2R3A A;  2IGQ A;  4IJ8 A;  4RZ0 A;  4WUY A;  3RQ4 A;  3K5K A;  5T0M A;  5TH7 A;  3F9X A;  4J7F A;  1H3I A;  1XQH A;  5F5E A;  4O30 A;  3QWW A;  3M56 A;  3M57 A;  5T0K A;  2W5Z A;  3SWC A;  3SW9 A;  3S7D A;  5AYF A;  3TG5 A;  4YPU A;  5HQ8 A;  2O8J A;  1MUF A;  3M54 A;  4NJ5 A;  5T5G A;  4BUP A;  4JLG A;  3IHX A;  3CBP A;  3PDN A;  5F59 A;  5KJM A;  1MVH A;  3VUZ A;  3HNA A;  4I51 A;  3EP0 A;  1O9S A;  2RFI A;  5EX0 A;  1N6C A;  1N6A A;  3RIB A;  4AU7 A;  5KJK A;  3KMT A;  5F6K C;  5JJ0 A;  3RAY A;  4MI0 A;  3CBM A;  4JDS A;  5LSZ A;  3VV0 A;  3KMA A;  4YPA A;  3BO5 A;  5ARG A;  4NVQ A;  3N71 A;  1N3J A;  4YND A;  5TTF A;  3S8P A;  3OXG A;  4QEP A;  1ZKK A;  5LSX A;  3M58 A;  4LDG A;  2QPW A;  1PEG A;  2W5Y A;  3CBO A;  3M5A A;  3OPE A;  3M59 A;  3QWP A;  1ML9 A;  5EG2 A; 
#chains in the Genus database with same CATH topology
 3M55 A;  3OS5 A;  3OOI A;  4O6F A;  3OXL A;  1MT6 A;  3QWV A;  3MO5 A;  2G46 A;  3MO0 A;  3OXF A;  2F69 A;  3S7B A;  4E47 A;  3F9W A;  2JV0 A;  4MI5 A;  3S7F A;  5JIY A;  3FPD A;  5HI7 A;  4YPE A;  4H12 A;  4J8O A;  5EX3 A;  5CCM A;  4IJD A;  5CCL A;  4J7I A;  3RJW A;  5JHN A;  5TEG A;  4QEO A;  2BQZ A;  3KMJ A;  4FMU A;  3F9Y A;  3F9Z A;  5F6L A;  4YNM A;  3TG4 A;  3S7J A;  5JIN A;  4Z4P A;  5ARF A;  5KJN A;  3DAL A;  1MVX A;  5CPR B;  4C1Q A;  3RU0 A;  4J83 A;  3MEK A;  4YNP A;  3DB5 A;  3MO2 A;  4QEN A;  5KJL A;  3M53 A;  2R3A A;  2IGQ A;  4IJ8 A;  4RZ0 A;  4WUY A;  3RQ4 A;  3K5K A;  5T0M A;  5TH7 A;  3F9X A;  4J7F A;  1H3I A;  1XQH A;  5F5E A;  4O30 A;  3QWW A;  3M56 A;  3M57 A;  5T0K A;  2W5Z A;  3SWC A;  3SW9 A;  3S7D A;  5AYF A;  3TG5 A;  4YPU A;  5HQ8 A;  2O8J A;  1MUF A;  3M54 A;  4NJ5 A;  5T5G A;  4BUP A;  4JLG A;  3IHX A;  3CBP A;  3PDN A;  5F59 A;  5KJM A;  1MVH A;  3VUZ A;  3HNA A;  4I51 A;  3EP0 A;  1O9S A;  2RFI A;  5EX0 A;  1N6C A;  1N6A A;  3RIB A;  4AU7 A;  5KJK A;  3KMT A;  5F6K C;  5JJ0 A;  3RAY A;  4MI0 A;  3CBM A;  4JDS A;  5LSZ A;  3VV0 A;  3KMA A;  4YPA A;  3BO5 A;  5ARG A;  4NVQ A;  3N71 A;  1N3J A;  4YND A;  5TTF A;  3S8P A;  3OXG A;  4QEP A;  1ZKK A;  5LSX A;  3M58 A;  4LDG A;  2QPW A;  1PEG A;  2W5Y A;  3CBO A;  3M5A A;  3OPE A;  3M59 A;  3QWP A;  1ML9 A;  5EG2 A; 
#chains in the Genus database with same CATH homology
 3M55 A;  3OS5 A;  3OOI A;  4O6F A;  3OXL A;  1MT6 A;  3QWV A;  3MO5 A;  2G46 A;  3MO0 A;  3OXF A;  2F69 A;  3S7B A;  4E47 A;  3F9W A;  2JV0 A;  4MI5 A;  3S7F A;  5JIY A;  3FPD A;  5HI7 A;  4YPE A;  4H12 A;  4J8O A;  5EX3 A;  5CCM A;  4IJD A;  5CCL A;  4J7I A;  3RJW A;  5JHN A;  5TEG A;  4QEO A;  2BQZ A;  3KMJ A;  4FMU A;  3F9Y A;  3F9Z A;  5F6L A;  4YNM A;  3TG4 A;  3S7J A;  5JIN A;  4Z4P A;  5ARF A;  5KJN A;  3DAL A;  1MVX A;  5CPR B;  4C1Q A;  3RU0 A;  4J83 A;  3MEK A;  4YNP A;  3DB5 A;  3MO2 A;  4QEN A;  5KJL A;  3M53 A;  2R3A A;  2IGQ A;  4IJ8 A;  4RZ0 A;  4WUY A;  3RQ4 A;  3K5K A;  5T0M A;  5TH7 A;  3F9X A;  4J7F A;  1H3I A;  1XQH A;  5F5E A;  4O30 A;  3QWW A;  3M56 A;  3M57 A;  5T0K A;  2W5Z A;  3SWC A;  3SW9 A;  3S7D A;  5AYF A;  3TG5 A;  4YPU A;  5HQ8 A;  2O8J A;  1MUF A;  3M54 A;  4NJ5 A;  5T5G A;  4BUP A;  4JLG A;  3IHX A;  3CBP A;  3PDN A;  5F59 A;  5KJM A;  1MVH A;  3VUZ A;  3HNA A;  4I51 A;  3EP0 A;  1O9S A;  2RFI A;  5EX0 A;  1N6C A;  1N6A A;  3RIB A;  4AU7 A;  5KJK A;  3KMT A;  5F6K C;  5JJ0 A;  3RAY A;  4MI0 A;  3CBM A;  4JDS A;  5LSZ A;  3VV0 A;  3KMA A;  4YPA A;  3BO5 A;  5ARG A;  4NVQ A;  3N71 A;  1N3J A;  4YND A;  5TTF A;  3S8P A;  3OXG A;  4QEP A;  1ZKK A;  5LSX A;  3M58 A;  4LDG A;  2QPW A;  1PEG A;  2W5Y A;  3CBO A;  3M5A A;  3OPE A;  3M59 A;  3QWP A;  1ML9 A;  5EG2 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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