1MUFA

Structure of histone h3 k4-specific methyltransferase set7/9
Total Genus 57
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
57
sequence length
257
structure length
257
Chain Sequence
VLQGTYVDGELNGPAQEYDTDGRLIFKGQYKDNIRHGVCWIYYPDGGSLVGEVNEDGEMTGEKIAYVYPDERTALYGKFIDGEMIEGKLATLMSTEEGRPHFELMPGNSVYHFDKSTSSCISTNALLPDPYESERVYVAESLISSAGEGLFSKVAVGPNTVMSFYNGVRITHQEVDSRDWALNGNTLSLDEETVIDVPEPYNHVSKYCASLGHKANHSFTPNCIYDMFVHPRFGPIKCIRTLRAVEADEELTVAYGY
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords SET9
publication title The active site of the SET domain is constructed on a knot
pubmed rcsb
source organism Homo sapiens
molecule tags Transferase
total genus 57
structure length 257
sequence length 257
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2002-09-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF02493 MORN MORN repeat
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.20.110.10 Mainly Beta Single Sheet Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain 1mufA01
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 1mufA02
2IGQA 3M55A 2W5ZA 1ML9A 5ARFA 4LDGA 4BUPA 3OXFA 3F9YA 3M56A 3EP0A 4NVQA 3QWWA 3OXGA 4MI0A 1N6AA 1H3IA 3QWVA 5EX0A 3HNAA 1XQHA 3M58A 3MO5A 2O8JA 3S7JA 3IHXA 1N3JA 4J83A 1PEGA 4J7FA 3RAYA 4RZ0A 3S7FA 3OOIA 4JLGA 3M59A 1MT6A 4QEOA 3MO2A 3S8PA 2F69A 2RFIA 3RJWA 4YPAA 3SWCA 3VV0A 5EX3A 1ZKKA 5JJ0A 3OS5A 3SW9A 3S7DA 3OPEA 1MUFA 3N71A 3DALA 4H12A 4I51A 3OXLA 2BQZA 4YPUA 3TG4A 5KJNA 3M57A 4JDSA 2G46A 3F9XA 5HQ8A 4MI5A 5CCLA 5F6KC 3RIBA 4C1QA 5KJMA 1N6CA 1MVXA 3DB5A 4NJ5A 5T0KA 4AU7A 3F9WA 5T0MA 4J7IA 4YNDA 4IJ8A 5AYFA 4O6FA 1O9SA 3FPDA 3KMJA 2W5YA 5HI7A 5CCMA 4YPEA 3M5AA 3CBOA 4FMUA 5JINA 2QPWA 3CBMA 4E47A 3KMTA 5EG2A 3TG5A 5CPRB 3M54A 4J8OA 5LSXA 5T5GA 5TH7A 4QEPA 3MEKA 3S7BA 3RQ4A 4YNPA 4WUYA 5JIYA 3CBPA 4O30A 5KJLA 1MVHA 5JHNA 4YNMA 5TEGA 3QWPA 3PDNA 5TTFA 3BO5A 2JV0A 5LSZA 5ARGA 5KJKA 3MO0A 3M53A 3KMAA 5F5EA 4Z4PA 3VUZA 5F6LA 2R3AA 4IJDA 4QENA 3RU0A 5F59A 3K5KA 3F9ZA
chains in the Genus database with same CATH superfamily
2IGQA 3M55A 2W5ZA 1ML9A 5ARFA 4LDGA 4BUPA 3OXFA 3F9YA 3M56A 3EP0A 4NVQA 3QWWA 3OXGA 4MI0A 1N6AA 1H3IA 3QWVA 5EX0A 3HNAA 1XQHA 3M58A 3MO5A 2O8JA 3S7JA 3IHXA 1N3JA 4J83A 1PEGA 4J7FA 3RAYA 4RZ0A 3S7FA 3OOIA 4JLGA 3M59A 1MT6A 4QEOA 3MO2A 3S8PA 2F69A 2RFIA 3RJWA 4YPAA 3SWCA 3VV0A 5EX3A 1ZKKA 5JJ0A 3OS5A 3SW9A 3S7DA 3OPEA 1MUFA 3N71A 3DALA 4H12A 4I51A 3OXLA 2BQZA 4YPUA 3TG4A 5KJNA 3M57A 4JDSA 2G46A 3F9XA 5HQ8A 4MI5A 5CCLA 5F6KC 3RIBA 4C1QA 5KJMA 1N6CA 1MVXA 3DB5A 4NJ5A 5T0KA 4AU7A 3F9WA 5T0MA 4J7IA 4YNDA 4IJ8A 5AYFA 4O6FA 1O9SA 3FPDA 3KMJA 2W5YA 5HI7A 5CCMA 4YPEA 3M5AA 3CBOA 4FMUA 5JINA 2QPWA 3CBMA 4E47A 3KMTA 5EG2A 3TG5A 5CPRB 3M54A 4J8OA 5LSXA 5T5GA 5TH7A 4QEPA 3MEKA 3S7BA 3RQ4A 4YNPA 4WUYA 5JIYA 3CBPA 4O30A 5KJLA 1MVHA 5JHNA 4YNMA 5TEGA 3QWPA 3PDNA 5TTFA 3BO5A 2JV0A 5LSZA 5ARGA 5KJKA 3MO0A 3M53A 3KMAA 5F5EA 4Z4PA 3VUZA 5F6LA 2R3AA 4IJDA 4QENA 3RU0A 5F59A 3K5KA 3F9ZA
chains in the Genus database with same CATH topology
2IGQA 3M55A 2W5ZA 1ML9A 5ARFA 4LDGA 4BUPA 3OXFA 3F9YA 3M56A 3EP0A 4NVQA 3QWWA 3OXGA 4MI0A 1N6AA 1H3IA 3QWVA 5EX0A 3HNAA 1XQHA 3M58A 3MO5A 2O8JA 3S7JA 3IHXA 1N3JA 4J83A 1PEGA 4J7FA 3RAYA 4RZ0A 3S7FA 3OOIA 4JLGA 3M59A 1MT6A 4QEOA 3MO2A 3S8PA 2F69A 2RFIA 3RJWA 4YPAA 3SWCA 3VV0A 5EX3A 1ZKKA 5JJ0A 3OS5A 3SW9A 3S7DA 3OPEA 1MUFA 3N71A 3DALA 4H12A 4I51A 3OXLA 2BQZA 4YPUA 3TG4A 5KJNA 3M57A 4JDSA 2G46A 3F9XA 5HQ8A 4MI5A 5CCLA 5F6KC 3RIBA 4C1QA 5KJMA 1N6CA 1MVXA 3DB5A 4NJ5A 5T0KA 4AU7A 3F9WA 5T0MA 4J7IA 4YNDA 4IJ8A 5AYFA 4O6FA 1O9SA 3FPDA 3KMJA 2W5YA 5HI7A 5CCMA 4YPEA 3M5AA 3CBOA 4FMUA 5JINA 2QPWA 3CBMA 4E47A 3KMTA 5EG2A 3TG5A 5CPRB 3M54A 4J8OA 5LSXA 5T5GA 5TH7A 4QEPA 3MEKA 3S7BA 3RQ4A 4YNPA 4WUYA 5JIYA 3CBPA 4O30A 5KJLA 1MVHA 5JHNA 4YNMA 5TEGA 3QWPA 3PDNA 5TTFA 3BO5A 2JV0A 5LSZA 5ARGA 5KJKA 3MO0A 3M53A 3KMAA 5F5EA 4Z4PA 3VUZA 5F6LA 2R3AA 4IJDA 4QENA 3RU0A 5F59A 3K5KA 3F9ZA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2IGQ A;  3M55 A;  2W5Z A;  1ML9 A;  5ARF A;  4LDG A;  4BUP A;  3OXF A;  3F9Y A;  3M56 A;  3EP0 A;  4NVQ A;  3QWW A;  3OXG A;  4MI0 A;  1N6A A;  1H3I A;  3QWV A;  5EX0 A;  3HNA A;  1XQH A;  3M58 A;  3MO5 A;  2O8J A;  3S7J A;  3IHX A;  1N3J A;  4J83 A;  1PEG A;  4J7F A;  3RAY A;  4RZ0 A;  3S7F A;  3OOI A;  4JLG A;  3M59 A;  1MT6 A;  4QEO A;  3MO2 A;  3S8P A;  2F69 A;  2RFI A;  3RJW A;  4YPA A;  3SWC A;  3VV0 A;  5EX3 A;  1ZKK A;  5JJ0 A;  3OS5 A;  3SW9 A;  3S7D A;  3OPE A;  1MUF A;  3N71 A;  3DAL A;  4H12 A;  4I51 A;  3OXL A;  2BQZ A;  4YPU A;  3TG4 A;  5KJN A;  3M57 A;  4JDS A;  2G46 A;  3F9X A;  5HQ8 A;  4MI5 A;  5CCL A;  5F6K C;  3RIB A;  4C1Q A;  5KJM A;  1N6C A;  1MVX A;  3DB5 A;  4NJ5 A;  5T0K A;  4AU7 A;  3F9W A;  5T0M A;  4J7I A;  4YND A;  4IJ8 A;  5AYF A;  4O6F A;  1O9S A;  3FPD A;  3KMJ A;  2W5Y A;  5HI7 A;  5CCM A;  4YPE A;  3M5A A;  3CBO A;  4FMU A;  5JIN A;  2QPW A;  3CBM A;  4E47 A;  3KMT A;  5EG2 A;  3TG5 A;  5CPR B;  3M54 A;  4J8O A;  5LSX A;  5T5G A;  5TH7 A;  4QEP A;  3MEK A;  3S7B A;  3RQ4 A;  4YNP A;  4WUY A;  5JIY A;  3CBP A;  4O30 A;  5KJL A;  1MVH A;  5JHN A;  4YNM A;  5TEG A;  3QWP A;  3PDN A;  5TTF A;  3BO5 A;  2JV0 A;  5LSZ A;  5ARG A;  5KJK A;  3MO0 A;  3M53 A;  3KMA A;  5F5E A;  4Z4P A;  3VUZ A;  5F6L A;  2R3A A;  4IJD A;  4QEN A;  3RU0 A;  5F59 A;  3K5K A;  3F9Z A; 
#chains in the Genus database with same CATH topology
 2IGQ A;  3M55 A;  2W5Z A;  1ML9 A;  5ARF A;  4LDG A;  4BUP A;  3OXF A;  3F9Y A;  3M56 A;  3EP0 A;  4NVQ A;  3QWW A;  3OXG A;  4MI0 A;  1N6A A;  1H3I A;  3QWV A;  5EX0 A;  3HNA A;  1XQH A;  3M58 A;  3MO5 A;  2O8J A;  3S7J A;  3IHX A;  1N3J A;  4J83 A;  1PEG A;  4J7F A;  3RAY A;  4RZ0 A;  3S7F A;  3OOI A;  4JLG A;  3M59 A;  1MT6 A;  4QEO A;  3MO2 A;  3S8P A;  2F69 A;  2RFI A;  3RJW A;  4YPA A;  3SWC A;  3VV0 A;  5EX3 A;  1ZKK A;  5JJ0 A;  3OS5 A;  3SW9 A;  3S7D A;  3OPE A;  1MUF A;  3N71 A;  3DAL A;  4H12 A;  4I51 A;  3OXL A;  2BQZ A;  4YPU A;  3TG4 A;  5KJN A;  3M57 A;  4JDS A;  2G46 A;  3F9X A;  5HQ8 A;  4MI5 A;  5CCL A;  5F6K C;  3RIB A;  4C1Q A;  5KJM A;  1N6C A;  1MVX A;  3DB5 A;  4NJ5 A;  5T0K A;  4AU7 A;  3F9W A;  5T0M A;  4J7I A;  4YND A;  4IJ8 A;  5AYF A;  4O6F A;  1O9S A;  3FPD A;  3KMJ A;  2W5Y A;  5HI7 A;  5CCM A;  4YPE A;  3M5A A;  3CBO A;  4FMU A;  5JIN A;  2QPW A;  3CBM A;  4E47 A;  3KMT A;  5EG2 A;  3TG5 A;  5CPR B;  3M54 A;  4J8O A;  5LSX A;  5T5G A;  5TH7 A;  4QEP A;  3MEK A;  3S7B A;  3RQ4 A;  4YNP A;  4WUY A;  5JIY A;  3CBP A;  4O30 A;  5KJL A;  1MVH A;  5JHN A;  4YNM A;  5TEG A;  3QWP A;  3PDN A;  5TTF A;  3BO5 A;  2JV0 A;  5LSZ A;  5ARG A;  5KJK A;  3MO0 A;  3M53 A;  3KMA A;  5F5E A;  4Z4P A;  3VUZ A;  5F6L A;  2R3A A;  4IJD A;  4QEN A;  3RU0 A;  5F59 A;  3K5K A;  3F9Z A; 
#chains in the Genus database with same CATH homology
 2IGQ A;  3M55 A;  2W5Z A;  1ML9 A;  5ARF A;  4LDG A;  4BUP A;  3OXF A;  3F9Y A;  3M56 A;  3EP0 A;  4NVQ A;  3QWW A;  3OXG A;  4MI0 A;  1N6A A;  1H3I A;  3QWV A;  5EX0 A;  3HNA A;  1XQH A;  3M58 A;  3MO5 A;  2O8J A;  3S7J A;  3IHX A;  1N3J A;  4J83 A;  1PEG A;  4J7F A;  3RAY A;  4RZ0 A;  3S7F A;  3OOI A;  4JLG A;  3M59 A;  1MT6 A;  4QEO A;  3MO2 A;  3S8P A;  2F69 A;  2RFI A;  3RJW A;  4YPA A;  3SWC A;  3VV0 A;  5EX3 A;  1ZKK A;  5JJ0 A;  3OS5 A;  3SW9 A;  3S7D A;  3OPE A;  1MUF A;  3N71 A;  3DAL A;  4H12 A;  4I51 A;  3OXL A;  2BQZ A;  4YPU A;  3TG4 A;  5KJN A;  3M57 A;  4JDS A;  2G46 A;  3F9X A;  5HQ8 A;  4MI5 A;  5CCL A;  5F6K C;  3RIB A;  4C1Q A;  5KJM A;  1N6C A;  1MVX A;  3DB5 A;  4NJ5 A;  5T0K A;  4AU7 A;  3F9W A;  5T0M A;  4J7I A;  4YND A;  4IJ8 A;  5AYF A;  4O6F A;  1O9S A;  3FPD A;  3KMJ A;  2W5Y A;  5HI7 A;  5CCM A;  4YPE A;  3M5A A;  3CBO A;  4FMU A;  5JIN A;  2QPW A;  3CBM A;  4E47 A;  3KMT A;  5EG2 A;  3TG5 A;  5CPR B;  3M54 A;  4J8O A;  5LSX A;  5T5G A;  5TH7 A;  4QEP A;  3MEK A;  3S7B A;  3RQ4 A;  4YNP A;  4WUY A;  5JIY A;  3CBP A;  4O30 A;  5KJL A;  1MVH A;  5JHN A;  4YNM A;  5TEG A;  3QWP A;  3PDN A;  5TTF A;  3BO5 A;  2JV0 A;  5LSZ A;  5ARG A;  5KJK A;  3MO0 A;  3M53 A;  3KMA A;  5F5E A;  4Z4P A;  3VUZ A;  5F6L A;  2R3A A;  4IJD A;  4QEN A;  3RU0 A;  5F59 A;  3K5K A;  3F9Z A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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