1MUFA

Structure of histone h3 k4-specific methyltransferase set7/9
Total Genus 57
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
57
sequence length
257
structure length
257
Chain Sequence
VLQGTYVDGELNGPAQEYDTDGRLIFKGQYKDNIRHGVCWIYYPDGGSLVGEVNEDGEMTGEKIAYVYPDERTALYGKFIDGEMIEGKLATLMSTEEGRPHFELMPGNSVYHFDKSTSSCISTNALLPDPYESERVYVAESLISSAGEGLFSKVAVGPNTVMSFYNGVRITHQEVDSRDWALNGNTLSLDEETVIDVPEPYNHVSKYCASLGHKANHSFTPNCIYDMFVHPRFGPIKCIRTLRAVEADEELTVAYGY
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The active site of the SET domain is constructed on a knot
pubmed rcsb
source organism Homo sapiens
molecule tags Transferase
molecule keywords SET9
total genus 57
structure length 257
sequence length 257
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2002-09-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF02493 MORN MORN repeat
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.20.110.10 Mainly Beta Single Sheet Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain 1mufA01
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 1mufA02
5T5GA 3BO5A 4QENA 5LSXA 4MI5A 2RFIA 2IGQA 3CBPA 4JLGA 4IJDA 3SWCA 5HQ8A 3S7BA 2F69A 4H12A 5T0KA 4BUPA 1H3IA 5EX3A 3VV0A 3M58A 3MO5A 3S7FA 5JHNA 3M53A 3F9YA 2QPWA 4MI0A 5TEGA 1MVHA 1MUFA 4NVQA 3TG4A 3VUZA 3M54A 1N3JA 1ML9A 5T0MA 3RAYA 3M5AA 5KJLA 2R3AA 4QEOA 5KJNA 3SW9A 4J7FA 3S7DA 5HI7A 5JINA 2W5ZA 3RIBA 5F5EA 3HNAA 4YNDA 5CPRB 4YNMA 4O30A 3DALA 1N6AA 1N6CA 5CCLA 1MVXA 3M59A 5AYFA 4IJ8A 3M56A 2BQZA 4C1QA 4QEPA 3KMJA 4RZ0A 4J8OA 4FMUA 3FPDA 5LSZA 3OXGA 3OS5A 5KJKA 3EP0A 5TTFA 1MT6A 3OPEA 5F59A 5EG2A 2W5YA 3OXFA 5F6LA 2JV0A 4LDGA 2G46A 4E47A 5ARGA 3CBOA 4JDSA 3F9ZA 3QWWA 4YPEA 3IHXA 4AU7A 4WUYA 1PEGA 3M57A 4Z4PA 3PDNA 3MO0A 5F6KC 2O8JA 4YPUA 1XQHA 3M55A 3S8PA 3RJWA 3F9XA 4NJ5A 4J83A 4YNPA 3QWPA 4I51A 3TG5A 3KMTA 3OXLA 3KMAA 4YPAA 1ZKKA 3RQ4A 3S7JA 5EX0A 1O9SA 5JJ0A 3RU0A 3CBMA 3OOIA 3QWVA 3F9WA 5JIYA 3N71A 3K5KA 3DB5A 5KJMA 5ARFA 5CCMA 4O6FA 5TH7A 3MO2A 4J7IA 3MEKA
chains in the Genus database with same CATH superfamily
5T5GA 3BO5A 4QENA 5LSXA 4MI5A 2RFIA 2IGQA 3CBPA 4JLGA 4IJDA 3SWCA 5HQ8A 3S7BA 2F69A 4H12A 5T0KA 4BUPA 1H3IA 5EX3A 3VV0A 3M58A 3MO5A 3S7FA 5JHNA 3M53A 3F9YA 2QPWA 4MI0A 5TEGA 1MVHA 1MUFA 4NVQA 3TG4A 3VUZA 3M54A 1N3JA 1ML9A 5T0MA 3RAYA 3M5AA 5KJLA 2R3AA 4QEOA 5KJNA 3SW9A 4J7FA 3S7DA 5HI7A 5JINA 2W5ZA 3RIBA 5F5EA 3HNAA 4YNDA 5CPRB 4YNMA 4O30A 3DALA 1N6AA 1N6CA 5CCLA 1MVXA 3M59A 5AYFA 4IJ8A 3M56A 2BQZA 4C1QA 4QEPA 3KMJA 4RZ0A 4J8OA 4FMUA 3FPDA 5LSZA 3OXGA 3OS5A 5KJKA 3EP0A 5TTFA 1MT6A 3OPEA 5F59A 5EG2A 2W5YA 3OXFA 5F6LA 2JV0A 4LDGA 2G46A 4E47A 5ARGA 3CBOA 4JDSA 3F9ZA 3QWWA 4YPEA 3IHXA 4AU7A 4WUYA 1PEGA 3M57A 4Z4PA 3PDNA 3MO0A 5F6KC 2O8JA 4YPUA 1XQHA 3M55A 3S8PA 3RJWA 3F9XA 4NJ5A 4J83A 4YNPA 3QWPA 4I51A 3TG5A 3KMTA 3OXLA 3KMAA 4YPAA 1ZKKA 3RQ4A 3S7JA 5EX0A 1O9SA 5JJ0A 3RU0A 3CBMA 3OOIA 3QWVA 3F9WA 5JIYA 3N71A 3K5KA 3DB5A 5KJMA 5ARFA 5CCMA 4O6FA 5TH7A 3MO2A 4J7IA 3MEKA
chains in the Genus database with same CATH topology
5T5GA 3BO5A 4QENA 5LSXA 4MI5A 2RFIA 2IGQA 3CBPA 4JLGA 4IJDA 3SWCA 5HQ8A 3S7BA 2F69A 4H12A 5T0KA 4BUPA 1H3IA 5EX3A 3VV0A 3M58A 3MO5A 3S7FA 5JHNA 3M53A 3F9YA 2QPWA 4MI0A 5TEGA 1MVHA 1MUFA 4NVQA 3TG4A 3VUZA 3M54A 1N3JA 1ML9A 5T0MA 3RAYA 3M5AA 5KJLA 2R3AA 4QEOA 5KJNA 3SW9A 4J7FA 3S7DA 5HI7A 5JINA 2W5ZA 3RIBA 5F5EA 3HNAA 4YNDA 5CPRB 4YNMA 4O30A 3DALA 1N6AA 1N6CA 5CCLA 1MVXA 3M59A 5AYFA 4IJ8A 3M56A 2BQZA 4C1QA 4QEPA 3KMJA 4RZ0A 4J8OA 4FMUA 3FPDA 5LSZA 3OXGA 3OS5A 5KJKA 3EP0A 5TTFA 1MT6A 3OPEA 5F59A 5EG2A 2W5YA 3OXFA 5F6LA 2JV0A 4LDGA 2G46A 4E47A 5ARGA 3CBOA 4JDSA 3F9ZA 3QWWA 4YPEA 3IHXA 4AU7A 4WUYA 1PEGA 3M57A 4Z4PA 3PDNA 3MO0A 5F6KC 2O8JA 4YPUA 1XQHA 3M55A 3S8PA 3RJWA 3F9XA 4NJ5A 4J83A 4YNPA 3QWPA 4I51A 3TG5A 3KMTA 3OXLA 3KMAA 4YPAA 1ZKKA 3RQ4A 3S7JA 5EX0A 1O9SA 5JJ0A 3RU0A 3CBMA 3OOIA 3QWVA 3F9WA 5JIYA 3N71A 3K5KA 3DB5A 5KJMA 5ARFA 5CCMA 4O6FA 5TH7A 3MO2A 4J7IA 3MEKA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5T5G A;  3BO5 A;  4QEN A;  5LSX A;  4MI5 A;  2RFI A;  2IGQ A;  3CBP A;  4JLG A;  4IJD A;  3SWC A;  5HQ8 A;  3S7B A;  2F69 A;  4H12 A;  5T0K A;  4BUP A;  1H3I A;  5EX3 A;  3VV0 A;  3M58 A;  3MO5 A;  3S7F A;  5JHN A;  3M53 A;  3F9Y A;  2QPW A;  4MI0 A;  5TEG A;  1MVH A;  1MUF A;  4NVQ A;  3TG4 A;  3VUZ A;  3M54 A;  1N3J A;  1ML9 A;  5T0M A;  3RAY A;  3M5A A;  5KJL A;  2R3A A;  4QEO A;  5KJN A;  3SW9 A;  4J7F A;  3S7D A;  5HI7 A;  5JIN A;  2W5Z A;  3RIB A;  5F5E A;  3HNA A;  4YND A;  5CPR B;  4YNM A;  4O30 A;  3DAL A;  1N6A A;  1N6C A;  5CCL A;  1MVX A;  3M59 A;  5AYF A;  4IJ8 A;  3M56 A;  2BQZ A;  4C1Q A;  4QEP A;  3KMJ A;  4RZ0 A;  4J8O A;  4FMU A;  3FPD A;  5LSZ A;  3OXG A;  3OS5 A;  5KJK A;  3EP0 A;  5TTF A;  1MT6 A;  3OPE A;  5F59 A;  5EG2 A;  2W5Y A;  3OXF A;  5F6L A;  2JV0 A;  4LDG A;  2G46 A;  4E47 A;  5ARG A;  3CBO A;  4JDS A;  3F9Z A;  3QWW A;  4YPE A;  3IHX A;  4AU7 A;  4WUY A;  1PEG A;  3M57 A;  4Z4P A;  3PDN A;  3MO0 A;  5F6K C;  2O8J A;  4YPU A;  1XQH A;  3M55 A;  3S8P A;  3RJW A;  3F9X A;  4NJ5 A;  4J83 A;  4YNP A;  3QWP A;  4I51 A;  3TG5 A;  3KMT A;  3OXL A;  3KMA A;  4YPA A;  1ZKK A;  3RQ4 A;  3S7J A;  5EX0 A;  1O9S A;  5JJ0 A;  3RU0 A;  3CBM A;  3OOI A;  3QWV A;  3F9W A;  5JIY A;  3N71 A;  3K5K A;  3DB5 A;  5KJM A;  5ARF A;  5CCM A;  4O6F A;  5TH7 A;  3MO2 A;  4J7I A;  3MEK A; 
#chains in the Genus database with same CATH topology
 5T5G A;  3BO5 A;  4QEN A;  5LSX A;  4MI5 A;  2RFI A;  2IGQ A;  3CBP A;  4JLG A;  4IJD A;  3SWC A;  5HQ8 A;  3S7B A;  2F69 A;  4H12 A;  5T0K A;  4BUP A;  1H3I A;  5EX3 A;  3VV0 A;  3M58 A;  3MO5 A;  3S7F A;  5JHN A;  3M53 A;  3F9Y A;  2QPW A;  4MI0 A;  5TEG A;  1MVH A;  1MUF A;  4NVQ A;  3TG4 A;  3VUZ A;  3M54 A;  1N3J A;  1ML9 A;  5T0M A;  3RAY A;  3M5A A;  5KJL A;  2R3A A;  4QEO A;  5KJN A;  3SW9 A;  4J7F A;  3S7D A;  5HI7 A;  5JIN A;  2W5Z A;  3RIB A;  5F5E A;  3HNA A;  4YND A;  5CPR B;  4YNM A;  4O30 A;  3DAL A;  1N6A A;  1N6C A;  5CCL A;  1MVX A;  3M59 A;  5AYF A;  4IJ8 A;  3M56 A;  2BQZ A;  4C1Q A;  4QEP A;  3KMJ A;  4RZ0 A;  4J8O A;  4FMU A;  3FPD A;  5LSZ A;  3OXG A;  3OS5 A;  5KJK A;  3EP0 A;  5TTF A;  1MT6 A;  3OPE A;  5F59 A;  5EG2 A;  2W5Y A;  3OXF A;  5F6L A;  2JV0 A;  4LDG A;  2G46 A;  4E47 A;  5ARG A;  3CBO A;  4JDS A;  3F9Z A;  3QWW A;  4YPE A;  3IHX A;  4AU7 A;  4WUY A;  1PEG A;  3M57 A;  4Z4P A;  3PDN A;  3MO0 A;  5F6K C;  2O8J A;  4YPU A;  1XQH A;  3M55 A;  3S8P A;  3RJW A;  3F9X A;  4NJ5 A;  4J83 A;  4YNP A;  3QWP A;  4I51 A;  3TG5 A;  3KMT A;  3OXL A;  3KMA A;  4YPA A;  1ZKK A;  3RQ4 A;  3S7J A;  5EX0 A;  1O9S A;  5JJ0 A;  3RU0 A;  3CBM A;  3OOI A;  3QWV A;  3F9W A;  5JIY A;  3N71 A;  3K5K A;  3DB5 A;  5KJM A;  5ARF A;  5CCM A;  4O6F A;  5TH7 A;  3MO2 A;  4J7I A;  3MEK A; 
#chains in the Genus database with same CATH homology
 5T5G A;  3BO5 A;  4QEN A;  5LSX A;  4MI5 A;  2RFI A;  2IGQ A;  3CBP A;  4JLG A;  4IJD A;  3SWC A;  5HQ8 A;  3S7B A;  2F69 A;  4H12 A;  5T0K A;  4BUP A;  1H3I A;  5EX3 A;  3VV0 A;  3M58 A;  3MO5 A;  3S7F A;  5JHN A;  3M53 A;  3F9Y A;  2QPW A;  4MI0 A;  5TEG A;  1MVH A;  1MUF A;  4NVQ A;  3TG4 A;  3VUZ A;  3M54 A;  1N3J A;  1ML9 A;  5T0M A;  3RAY A;  3M5A A;  5KJL A;  2R3A A;  4QEO A;  5KJN A;  3SW9 A;  4J7F A;  3S7D A;  5HI7 A;  5JIN A;  2W5Z A;  3RIB A;  5F5E A;  3HNA A;  4YND A;  5CPR B;  4YNM A;  4O30 A;  3DAL A;  1N6A A;  1N6C A;  5CCL A;  1MVX A;  3M59 A;  5AYF A;  4IJ8 A;  3M56 A;  2BQZ A;  4C1Q A;  4QEP A;  3KMJ A;  4RZ0 A;  4J8O A;  4FMU A;  3FPD A;  5LSZ A;  3OXG A;  3OS5 A;  5KJK A;  3EP0 A;  5TTF A;  1MT6 A;  3OPE A;  5F59 A;  5EG2 A;  2W5Y A;  3OXF A;  5F6L A;  2JV0 A;  4LDG A;  2G46 A;  4E47 A;  5ARG A;  3CBO A;  4JDS A;  3F9Z A;  3QWW A;  4YPE A;  3IHX A;  4AU7 A;  4WUY A;  1PEG A;  3M57 A;  4Z4P A;  3PDN A;  3MO0 A;  5F6K C;  2O8J A;  4YPU A;  1XQH A;  3M55 A;  3S8P A;  3RJW A;  3F9X A;  4NJ5 A;  4J83 A;  4YNP A;  3QWP A;  4I51 A;  3TG5 A;  3KMT A;  3OXL A;  3KMA A;  4YPA A;  1ZKK A;  3RQ4 A;  3S7J A;  5EX0 A;  1O9S A;  5JJ0 A;  3RU0 A;  3CBM A;  3OOI A;  3QWV A;  3F9W A;  5JIY A;  3N71 A;  3K5K A;  3DB5 A;  5KJM A;  5ARF A;  5CCM A;  4O6F A;  5TH7 A;  3MO2 A;  4J7I A;  3MEK A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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