1MUFA

Structure of histone h3 k4-specific methyltransferase set7/9
Total Genus 57
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
57
sequence length
257
structure length
257
Chain Sequence
VLQGTYVDGELNGPAQEYDTDGRLIFKGQYKDNIRHGVCWIYYPDGGSLVGEVNEDGEMTGEKIAYVYPDERTALYGKFIDGEMIEGKLATLMSTEEGRPHFELMPGNSVYHFDKSTSSCISTNALLPDPYESERVYVAESLISSAGEGLFSKVAVGPNTVMSFYNGVRITHQEVDSRDWALNGNTLSLDEETVIDVPEPYNHVSKYCASLGHKANHSFTPNCIYDMFVHPRFGPIKCIRTLRAVEADEELTVAYGY
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Transferase
molecule keywords SET9
publication title The active site of the SET domain is constructed on a knot
pubmed rcsb
source organism Homo sapiens
total genus 57
structure length 257
sequence length 257
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2002-09-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF02493 MORN MORN repeat
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.20.110.10 Mainly Beta Single Sheet Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain 1mufA01
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 1mufA02
4Z4PA 3DB5A 4QEOA 4BUPA 3RJWA 1ZKKA 3MO0A 3QWWA 3FPDA 5KJNA 4MI5A 1PEGA 2W5YA 4AU7A 3F9XA 1N3JA 5JJ0A 2QPWA 4NVQA 3OXLA 3QWVA 3MO2A 4JLGA 5LSXA 2G46A 3M5AA 4NJ5A 3BO5A 3PDNA 4C1QA 3RQ4A 1MVXA 4I51A 4H12A 1O9SA 3DALA 4YPUA 3OXGA 5TH7A 5CCMA 5LSZA 3RAYA 3TG5A 3K5KA 5ARFA 4O6FA 3KMAA 4J7IA 3M55A 1H3IA 3M57A 5ARGA 2IGQA 3M53A 2RFIA 4O30A 3M58A 3CBOA 5F6LA 5KJLA 4LDGA 4J83A 1N6CA 3MO5A 1N6AA 4E47A 3VUZA 3HNAA 2O8JA 3SW9A 5JINA 3S7JA 5KJKA 3CBPA 3M59A 1MT6A 3F9YA 3MEKA 3F9WA 3M56A 1XQHA 5HI7A 3KMJA 5AYFA 3RIBA 5HQ8A 2F69A 1ML9A 3SWCA 3N71A 3F9ZA 5EX3A 5TTFA 3OOIA 3VV0A 5T5GA 5T0MA 1MVHA 3OPEA 3TG4A 3KMTA 5JHNA 5KJMA 3QWPA 5F5EA 4YPEA 3OXFA 3S7BA 4J8OA 3EP0A 4YPAA 5F6KC 4RZ0A 4YNDA 4IJ8A 4YNPA 4YNMA 2BQZA 3RU0A 4J7FA 2R3AA 5T0KA 4QENA 3IHXA 5EG2A 3S7FA 1MUFA 5F59A 5TEGA 4MI0A 4QEPA 2JV0A 3M54A 5EX0A 4IJDA 4WUYA 3CBMA 3OS5A 4FMUA 4JDSA 5CPRB 3S7DA 3S8PA 5CCLA 2W5ZA 5JIYA
chains in the Genus database with same CATH superfamily
4Z4PA 3DB5A 4QEOA 4BUPA 3RJWA 1ZKKA 3MO0A 3QWWA 3FPDA 5KJNA 4MI5A 1PEGA 2W5YA 4AU7A 3F9XA 1N3JA 5JJ0A 2QPWA 4NVQA 3OXLA 3QWVA 3MO2A 4JLGA 5LSXA 2G46A 3M5AA 4NJ5A 3BO5A 3PDNA 4C1QA 3RQ4A 1MVXA 4I51A 4H12A 1O9SA 3DALA 4YPUA 3OXGA 5TH7A 5CCMA 5LSZA 3RAYA 3TG5A 3K5KA 5ARFA 4O6FA 3KMAA 4J7IA 3M55A 1H3IA 3M57A 5ARGA 2IGQA 3M53A 2RFIA 4O30A 3M58A 3CBOA 5F6LA 5KJLA 4LDGA 4J83A 1N6CA 3MO5A 1N6AA 4E47A 3VUZA 3HNAA 2O8JA 3SW9A 5JINA 3S7JA 5KJKA 3CBPA 3M59A 1MT6A 3F9YA 3MEKA 3F9WA 3M56A 1XQHA 5HI7A 3KMJA 5AYFA 3RIBA 5HQ8A 2F69A 1ML9A 3SWCA 3N71A 3F9ZA 5EX3A 5TTFA 3OOIA 3VV0A 5T5GA 5T0MA 1MVHA 3OPEA 3TG4A 3KMTA 5JHNA 5KJMA 3QWPA 5F5EA 4YPEA 3OXFA 3S7BA 4J8OA 3EP0A 4YPAA 5F6KC 4RZ0A 4YNDA 4IJ8A 4YNPA 4YNMA 2BQZA 3RU0A 4J7FA 2R3AA 5T0KA 4QENA 3IHXA 5EG2A 3S7FA 1MUFA 5F59A 5TEGA 4MI0A 4QEPA 2JV0A 3M54A 5EX0A 4IJDA 4WUYA 3CBMA 3OS5A 4FMUA 4JDSA 5CPRB 3S7DA 3S8PA 5CCLA 2W5ZA 5JIYA
chains in the Genus database with same CATH topology
4Z4PA 3DB5A 4QEOA 4BUPA 3RJWA 1ZKKA 3MO0A 3QWWA 3FPDA 5KJNA 4MI5A 1PEGA 2W5YA 4AU7A 3F9XA 1N3JA 5JJ0A 2QPWA 4NVQA 3OXLA 3QWVA 3MO2A 4JLGA 5LSXA 2G46A 3M5AA 4NJ5A 3BO5A 3PDNA 4C1QA 3RQ4A 1MVXA 4I51A 4H12A 1O9SA 3DALA 4YPUA 3OXGA 5TH7A 5CCMA 5LSZA 3RAYA 3TG5A 3K5KA 5ARFA 4O6FA 3KMAA 4J7IA 3M55A 1H3IA 3M57A 5ARGA 2IGQA 3M53A 2RFIA 4O30A 3M58A 3CBOA 5F6LA 5KJLA 4LDGA 4J83A 1N6CA 3MO5A 1N6AA 4E47A 3VUZA 3HNAA 2O8JA 3SW9A 5JINA 3S7JA 5KJKA 3CBPA 3M59A 1MT6A 3F9YA 3MEKA 3F9WA 3M56A 1XQHA 5HI7A 3KMJA 5AYFA 3RIBA 5HQ8A 2F69A 1ML9A 3SWCA 3N71A 3F9ZA 5EX3A 5TTFA 3OOIA 3VV0A 5T5GA 5T0MA 1MVHA 3OPEA 3TG4A 3KMTA 5JHNA 5KJMA 3QWPA 5F5EA 4YPEA 3OXFA 3S7BA 4J8OA 3EP0A 4YPAA 5F6KC 4RZ0A 4YNDA 4IJ8A 4YNPA 4YNMA 2BQZA 3RU0A 4J7FA 2R3AA 5T0KA 4QENA 3IHXA 5EG2A 3S7FA 1MUFA 5F59A 5TEGA 4MI0A 4QEPA 2JV0A 3M54A 5EX0A 4IJDA 4WUYA 3CBMA 3OS5A 4FMUA 4JDSA 5CPRB 3S7DA 3S8PA 5CCLA 2W5ZA 5JIYA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4Z4P A;  3DB5 A;  4QEO A;  4BUP A;  3RJW A;  1ZKK A;  3MO0 A;  3QWW A;  3FPD A;  5KJN A;  4MI5 A;  1PEG A;  2W5Y A;  4AU7 A;  3F9X A;  1N3J A;  5JJ0 A;  2QPW A;  4NVQ A;  3OXL A;  3QWV A;  3MO2 A;  4JLG A;  5LSX A;  2G46 A;  3M5A A;  4NJ5 A;  3BO5 A;  3PDN A;  4C1Q A;  3RQ4 A;  1MVX A;  4I51 A;  4H12 A;  1O9S A;  3DAL A;  4YPU A;  3OXG A;  5TH7 A;  5CCM A;  5LSZ A;  3RAY A;  3TG5 A;  3K5K A;  5ARF A;  4O6F A;  3KMA A;  4J7I A;  3M55 A;  1H3I A;  3M57 A;  5ARG A;  2IGQ A;  3M53 A;  2RFI A;  4O30 A;  3M58 A;  3CBO A;  5F6L A;  5KJL A;  4LDG A;  4J83 A;  1N6C A;  3MO5 A;  1N6A A;  4E47 A;  3VUZ A;  3HNA A;  2O8J A;  3SW9 A;  5JIN A;  3S7J A;  5KJK A;  3CBP A;  3M59 A;  1MT6 A;  3F9Y A;  3MEK A;  3F9W A;  3M56 A;  1XQH A;  5HI7 A;  3KMJ A;  5AYF A;  3RIB A;  5HQ8 A;  2F69 A;  1ML9 A;  3SWC A;  3N71 A;  3F9Z A;  5EX3 A;  5TTF A;  3OOI A;  3VV0 A;  5T5G A;  5T0M A;  1MVH A;  3OPE A;  3TG4 A;  3KMT A;  5JHN A;  5KJM A;  3QWP A;  5F5E A;  4YPE A;  3OXF A;  3S7B A;  4J8O A;  3EP0 A;  4YPA A;  5F6K C;  4RZ0 A;  4YND A;  4IJ8 A;  4YNP A;  4YNM A;  2BQZ A;  3RU0 A;  4J7F A;  2R3A A;  5T0K A;  4QEN A;  3IHX A;  5EG2 A;  3S7F A;  1MUF A;  5F59 A;  5TEG A;  4MI0 A;  4QEP A;  2JV0 A;  3M54 A;  5EX0 A;  4IJD A;  4WUY A;  3CBM A;  3OS5 A;  4FMU A;  4JDS A;  5CPR B;  3S7D A;  3S8P A;  5CCL A;  2W5Z A;  5JIY A; 
#chains in the Genus database with same CATH topology
 4Z4P A;  3DB5 A;  4QEO A;  4BUP A;  3RJW A;  1ZKK A;  3MO0 A;  3QWW A;  3FPD A;  5KJN A;  4MI5 A;  1PEG A;  2W5Y A;  4AU7 A;  3F9X A;  1N3J A;  5JJ0 A;  2QPW A;  4NVQ A;  3OXL A;  3QWV A;  3MO2 A;  4JLG A;  5LSX A;  2G46 A;  3M5A A;  4NJ5 A;  3BO5 A;  3PDN A;  4C1Q A;  3RQ4 A;  1MVX A;  4I51 A;  4H12 A;  1O9S A;  3DAL A;  4YPU A;  3OXG A;  5TH7 A;  5CCM A;  5LSZ A;  3RAY A;  3TG5 A;  3K5K A;  5ARF A;  4O6F A;  3KMA A;  4J7I A;  3M55 A;  1H3I A;  3M57 A;  5ARG A;  2IGQ A;  3M53 A;  2RFI A;  4O30 A;  3M58 A;  3CBO A;  5F6L A;  5KJL A;  4LDG A;  4J83 A;  1N6C A;  3MO5 A;  1N6A A;  4E47 A;  3VUZ A;  3HNA A;  2O8J A;  3SW9 A;  5JIN A;  3S7J A;  5KJK A;  3CBP A;  3M59 A;  1MT6 A;  3F9Y A;  3MEK A;  3F9W A;  3M56 A;  1XQH A;  5HI7 A;  3KMJ A;  5AYF A;  3RIB A;  5HQ8 A;  2F69 A;  1ML9 A;  3SWC A;  3N71 A;  3F9Z A;  5EX3 A;  5TTF A;  3OOI A;  3VV0 A;  5T5G A;  5T0M A;  1MVH A;  3OPE A;  3TG4 A;  3KMT A;  5JHN A;  5KJM A;  3QWP A;  5F5E A;  4YPE A;  3OXF A;  3S7B A;  4J8O A;  3EP0 A;  4YPA A;  5F6K C;  4RZ0 A;  4YND A;  4IJ8 A;  4YNP A;  4YNM A;  2BQZ A;  3RU0 A;  4J7F A;  2R3A A;  5T0K A;  4QEN A;  3IHX A;  5EG2 A;  3S7F A;  1MUF A;  5F59 A;  5TEG A;  4MI0 A;  4QEP A;  2JV0 A;  3M54 A;  5EX0 A;  4IJD A;  4WUY A;  3CBM A;  3OS5 A;  4FMU A;  4JDS A;  5CPR B;  3S7D A;  3S8P A;  5CCL A;  2W5Z A;  5JIY A; 
#chains in the Genus database with same CATH homology
 4Z4P A;  3DB5 A;  4QEO A;  4BUP A;  3RJW A;  1ZKK A;  3MO0 A;  3QWW A;  3FPD A;  5KJN A;  4MI5 A;  1PEG A;  2W5Y A;  4AU7 A;  3F9X A;  1N3J A;  5JJ0 A;  2QPW A;  4NVQ A;  3OXL A;  3QWV A;  3MO2 A;  4JLG A;  5LSX A;  2G46 A;  3M5A A;  4NJ5 A;  3BO5 A;  3PDN A;  4C1Q A;  3RQ4 A;  1MVX A;  4I51 A;  4H12 A;  1O9S A;  3DAL A;  4YPU A;  3OXG A;  5TH7 A;  5CCM A;  5LSZ A;  3RAY A;  3TG5 A;  3K5K A;  5ARF A;  4O6F A;  3KMA A;  4J7I A;  3M55 A;  1H3I A;  3M57 A;  5ARG A;  2IGQ A;  3M53 A;  2RFI A;  4O30 A;  3M58 A;  3CBO A;  5F6L A;  5KJL A;  4LDG A;  4J83 A;  1N6C A;  3MO5 A;  1N6A A;  4E47 A;  3VUZ A;  3HNA A;  2O8J A;  3SW9 A;  5JIN A;  3S7J A;  5KJK A;  3CBP A;  3M59 A;  1MT6 A;  3F9Y A;  3MEK A;  3F9W A;  3M56 A;  1XQH A;  5HI7 A;  3KMJ A;  5AYF A;  3RIB A;  5HQ8 A;  2F69 A;  1ML9 A;  3SWC A;  3N71 A;  3F9Z A;  5EX3 A;  5TTF A;  3OOI A;  3VV0 A;  5T5G A;  5T0M A;  1MVH A;  3OPE A;  3TG4 A;  3KMT A;  5JHN A;  5KJM A;  3QWP A;  5F5E A;  4YPE A;  3OXF A;  3S7B A;  4J8O A;  3EP0 A;  4YPA A;  5F6K C;  4RZ0 A;  4YND A;  4IJ8 A;  4YNP A;  4YNM A;  2BQZ A;  3RU0 A;  4J7F A;  2R3A A;  5T0K A;  4QEN A;  3IHX A;  5EG2 A;  3S7F A;  1MUF A;  5F59 A;  5TEG A;  4MI0 A;  4QEP A;  2JV0 A;  3M54 A;  5EX0 A;  4IJD A;  4WUY A;  3CBM A;  3OS5 A;  4FMU A;  4JDS A;  5CPR B;  3S7D A;  3S8P A;  5CCL A;  2W5Z A;  5JIY A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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