1MUFA

Structure of histone h3 k4-specific methyltransferase set7/9
Total Genus 57
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
57
sequence length
257
structure length
257
Chain Sequence
VLQGTYVDGELNGPAQEYDTDGRLIFKGQYKDNIRHGVCWIYYPDGGSLVGEVNEDGEMTGEKIAYVYPDERTALYGKFIDGEMIEGKLATLMSTEEGRPHFELMPGNSVYHFDKSTSSCISTNALLPDPYESERVYVAESLISSAGEGLFSKVAVGPNTVMSFYNGVRITHQEVDSRDWALNGNTLSLDEETVIDVPEPYNHVSKYCASLGHKANHSFTPNCIYDMFVHPRFGPIKCIRTLRAVEADEELTVAYGY
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The active site of the SET domain is constructed on a knot
pubmed rcsb
source organism Homo sapiens
molecule tags Transferase
molecule keywords SET9
total genus 57
structure length 257
sequence length 257
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2002-09-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00856 SET SET domain
A PF02493 MORN MORN repeat
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.20.110.10 Mainly Beta Single Sheet Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain 1mufA01
2.170.270.10 Mainly Beta Beta Complex Beta-clip-like SET domain 1mufA02
5TEGA 2G46A 5KJNA 4MI5A 3EP0A 4Z4PA 2BQZA 1N6AA 4J83A 3QWVA 3M53A 3M54A 3KMJA 3KMAA 4YNMA 4O6FA 4QENA 4C1QA 3MO0A 4I51A 2W5ZA 3QWWA 5ARFA 3OXFA 4BUPA 5CCMA 3MO2A 3MO5A 3VV0A 2QPWA 1MUFA 3M58A 3S7DA 3CBPA 5LSXA 1N3JA 5CCLA 3HNAA 2JV0A 3S8PA 5HI7A 1N6CA 3MEKA 3RIBA 3KMTA 3RAYA 5JIYA 3RU0A 5EX0A 3N71A 2IGQA 3OOIA 1PEGA 3TG4A 3F9XA 5JHNA 1ZKKA 1XQHA 3F9YA 3IHXA 4AU7A 3S7FA 5EX3A 5LSZA 3SWCA 4O30A 3QWPA 4H12A 4NJ5A 4J7FA 5T0KA 4J8OA 3DB5A 5F6LA 3F9ZA 5JJ0A 3OS5A 3CBOA 4IJDA 5F59A 5TTFA 4RZ0A 4YPAA 2R3AA 3OXGA 4FMUA 5EG2A 1H3IA 3BO5A 4YPUA 5JINA 3S7BA 4QEOA 5ARGA 5CPRB 3FPDA 3OXLA 4YNDA 3SW9A 5KJKA 4JDSA 4QEPA 4LDGA 3RQ4A 1ML9A 3OPEA 3DALA 2RFIA 2W5YA 3M59A 4WUYA 3RJWA 3M56A 4E47A 2F69A 2O8JA 1MVHA 4YNPA 4J7IA 3TG5A 3M55A 5KJLA 1MT6A 5F6KC 5AYFA 4MI0A 1O9SA 5KJMA 4JLGA 5TH7A 3S7JA 5F5EA 4IJ8A 3M5AA 1MVXA 3PDNA 3K5KA 3CBMA 4YPEA 5HQ8A 3M57A 5T5GA 4NVQA 5T0MA 3VUZA 3F9WA
chains in the Genus database with same CATH superfamily
5TEGA 2G46A 5KJNA 4MI5A 3EP0A 4Z4PA 2BQZA 1N6AA 4J83A 3QWVA 3M53A 3M54A 3KMJA 3KMAA 4YNMA 4O6FA 4QENA 4C1QA 3MO0A 4I51A 2W5ZA 3QWWA 5ARFA 3OXFA 4BUPA 5CCMA 3MO2A 3MO5A 3VV0A 2QPWA 1MUFA 3M58A 3S7DA 3CBPA 5LSXA 1N3JA 5CCLA 3HNAA 2JV0A 3S8PA 5HI7A 1N6CA 3MEKA 3RIBA 3KMTA 3RAYA 5JIYA 3RU0A 5EX0A 3N71A 2IGQA 3OOIA 1PEGA 3TG4A 3F9XA 5JHNA 1ZKKA 1XQHA 3F9YA 3IHXA 4AU7A 3S7FA 5EX3A 5LSZA 3SWCA 4O30A 3QWPA 4H12A 4NJ5A 4J7FA 5T0KA 4J8OA 3DB5A 5F6LA 3F9ZA 5JJ0A 3OS5A 3CBOA 4IJDA 5F59A 5TTFA 4RZ0A 4YPAA 2R3AA 3OXGA 4FMUA 5EG2A 1H3IA 3BO5A 4YPUA 5JINA 3S7BA 4QEOA 5ARGA 5CPRB 3FPDA 3OXLA 4YNDA 3SW9A 5KJKA 4JDSA 4QEPA 4LDGA 3RQ4A 1ML9A 3OPEA 3DALA 2RFIA 2W5YA 3M59A 4WUYA 3RJWA 3M56A 4E47A 2F69A 2O8JA 1MVHA 4YNPA 4J7IA 3TG5A 3M55A 5KJLA 1MT6A 5F6KC 5AYFA 4MI0A 1O9SA 5KJMA 4JLGA 5TH7A 3S7JA 5F5EA 4IJ8A 3M5AA 1MVXA 3PDNA 3K5KA 3CBMA 4YPEA 5HQ8A 3M57A 5T5GA 4NVQA 5T0MA 3VUZA 3F9WA
chains in the Genus database with same CATH topology
5TEGA 2G46A 5KJNA 4MI5A 3EP0A 4Z4PA 2BQZA 1N6AA 4J83A 3QWVA 3M53A 3M54A 3KMJA 3KMAA 4YNMA 4O6FA 4QENA 4C1QA 3MO0A 4I51A 2W5ZA 3QWWA 5ARFA 3OXFA 4BUPA 5CCMA 3MO2A 3MO5A 3VV0A 2QPWA 1MUFA 3M58A 3S7DA 3CBPA 5LSXA 1N3JA 5CCLA 3HNAA 2JV0A 3S8PA 5HI7A 1N6CA 3MEKA 3RIBA 3KMTA 3RAYA 5JIYA 3RU0A 5EX0A 3N71A 2IGQA 3OOIA 1PEGA 3TG4A 3F9XA 5JHNA 1ZKKA 1XQHA 3F9YA 3IHXA 4AU7A 3S7FA 5EX3A 5LSZA 3SWCA 4O30A 3QWPA 4H12A 4NJ5A 4J7FA 5T0KA 4J8OA 3DB5A 5F6LA 3F9ZA 5JJ0A 3OS5A 3CBOA 4IJDA 5F59A 5TTFA 4RZ0A 4YPAA 2R3AA 3OXGA 4FMUA 5EG2A 1H3IA 3BO5A 4YPUA 5JINA 3S7BA 4QEOA 5ARGA 5CPRB 3FPDA 3OXLA 4YNDA 3SW9A 5KJKA 4JDSA 4QEPA 4LDGA 3RQ4A 1ML9A 3OPEA 3DALA 2RFIA 2W5YA 3M59A 4WUYA 3RJWA 3M56A 4E47A 2F69A 2O8JA 1MVHA 4YNPA 4J7IA 3TG5A 3M55A 5KJLA 1MT6A 5F6KC 5AYFA 4MI0A 1O9SA 5KJMA 4JLGA 5TH7A 3S7JA 5F5EA 4IJ8A 3M5AA 1MVXA 3PDNA 3K5KA 3CBMA 4YPEA 5HQ8A 3M57A 5T5GA 4NVQA 5T0MA 3VUZA 3F9WA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5TEG A;  2G46 A;  5KJN A;  4MI5 A;  3EP0 A;  4Z4P A;  2BQZ A;  1N6A A;  4J83 A;  3QWV A;  3M53 A;  3M54 A;  3KMJ A;  3KMA A;  4YNM A;  4O6F A;  4QEN A;  4C1Q A;  3MO0 A;  4I51 A;  2W5Z A;  3QWW A;  5ARF A;  3OXF A;  4BUP A;  5CCM A;  3MO2 A;  3MO5 A;  3VV0 A;  2QPW A;  1MUF A;  3M58 A;  3S7D A;  3CBP A;  5LSX A;  1N3J A;  5CCL A;  3HNA A;  2JV0 A;  3S8P A;  5HI7 A;  1N6C A;  3MEK A;  3RIB A;  3KMT A;  3RAY A;  5JIY A;  3RU0 A;  5EX0 A;  3N71 A;  2IGQ A;  3OOI A;  1PEG A;  3TG4 A;  3F9X A;  5JHN A;  1ZKK A;  1XQH A;  3F9Y A;  3IHX A;  4AU7 A;  3S7F A;  5EX3 A;  5LSZ A;  3SWC A;  4O30 A;  3QWP A;  4H12 A;  4NJ5 A;  4J7F A;  5T0K A;  4J8O A;  3DB5 A;  5F6L A;  3F9Z A;  5JJ0 A;  3OS5 A;  3CBO A;  4IJD A;  5F59 A;  5TTF A;  4RZ0 A;  4YPA A;  2R3A A;  3OXG A;  4FMU A;  5EG2 A;  1H3I A;  3BO5 A;  4YPU A;  5JIN A;  3S7B A;  4QEO A;  5ARG A;  5CPR B;  3FPD A;  3OXL A;  4YND A;  3SW9 A;  5KJK A;  4JDS A;  4QEP A;  4LDG A;  3RQ4 A;  1ML9 A;  3OPE A;  3DAL A;  2RFI A;  2W5Y A;  3M59 A;  4WUY A;  3RJW A;  3M56 A;  4E47 A;  2F69 A;  2O8J A;  1MVH A;  4YNP A;  4J7I A;  3TG5 A;  3M55 A;  5KJL A;  1MT6 A;  5F6K C;  5AYF A;  4MI0 A;  1O9S A;  5KJM A;  4JLG A;  5TH7 A;  3S7J A;  5F5E A;  4IJ8 A;  3M5A A;  1MVX A;  3PDN A;  3K5K A;  3CBM A;  4YPE A;  5HQ8 A;  3M57 A;  5T5G A;  4NVQ A;  5T0M A;  3VUZ A;  3F9W A; 
#chains in the Genus database with same CATH topology
 5TEG A;  2G46 A;  5KJN A;  4MI5 A;  3EP0 A;  4Z4P A;  2BQZ A;  1N6A A;  4J83 A;  3QWV A;  3M53 A;  3M54 A;  3KMJ A;  3KMA A;  4YNM A;  4O6F A;  4QEN A;  4C1Q A;  3MO0 A;  4I51 A;  2W5Z A;  3QWW A;  5ARF A;  3OXF A;  4BUP A;  5CCM A;  3MO2 A;  3MO5 A;  3VV0 A;  2QPW A;  1MUF A;  3M58 A;  3S7D A;  3CBP A;  5LSX A;  1N3J A;  5CCL A;  3HNA A;  2JV0 A;  3S8P A;  5HI7 A;  1N6C A;  3MEK A;  3RIB A;  3KMT A;  3RAY A;  5JIY A;  3RU0 A;  5EX0 A;  3N71 A;  2IGQ A;  3OOI A;  1PEG A;  3TG4 A;  3F9X A;  5JHN A;  1ZKK A;  1XQH A;  3F9Y A;  3IHX A;  4AU7 A;  3S7F A;  5EX3 A;  5LSZ A;  3SWC A;  4O30 A;  3QWP A;  4H12 A;  4NJ5 A;  4J7F A;  5T0K A;  4J8O A;  3DB5 A;  5F6L A;  3F9Z A;  5JJ0 A;  3OS5 A;  3CBO A;  4IJD A;  5F59 A;  5TTF A;  4RZ0 A;  4YPA A;  2R3A A;  3OXG A;  4FMU A;  5EG2 A;  1H3I A;  3BO5 A;  4YPU A;  5JIN A;  3S7B A;  4QEO A;  5ARG A;  5CPR B;  3FPD A;  3OXL A;  4YND A;  3SW9 A;  5KJK A;  4JDS A;  4QEP A;  4LDG A;  3RQ4 A;  1ML9 A;  3OPE A;  3DAL A;  2RFI A;  2W5Y A;  3M59 A;  4WUY A;  3RJW A;  3M56 A;  4E47 A;  2F69 A;  2O8J A;  1MVH A;  4YNP A;  4J7I A;  3TG5 A;  3M55 A;  5KJL A;  1MT6 A;  5F6K C;  5AYF A;  4MI0 A;  1O9S A;  5KJM A;  4JLG A;  5TH7 A;  3S7J A;  5F5E A;  4IJ8 A;  3M5A A;  1MVX A;  3PDN A;  3K5K A;  3CBM A;  4YPE A;  5HQ8 A;  3M57 A;  5T5G A;  4NVQ A;  5T0M A;  3VUZ A;  3F9W A; 
#chains in the Genus database with same CATH homology
 5TEG A;  2G46 A;  5KJN A;  4MI5 A;  3EP0 A;  4Z4P A;  2BQZ A;  1N6A A;  4J83 A;  3QWV A;  3M53 A;  3M54 A;  3KMJ A;  3KMA A;  4YNM A;  4O6F A;  4QEN A;  4C1Q A;  3MO0 A;  4I51 A;  2W5Z A;  3QWW A;  5ARF A;  3OXF A;  4BUP A;  5CCM A;  3MO2 A;  3MO5 A;  3VV0 A;  2QPW A;  1MUF A;  3M58 A;  3S7D A;  3CBP A;  5LSX A;  1N3J A;  5CCL A;  3HNA A;  2JV0 A;  3S8P A;  5HI7 A;  1N6C A;  3MEK A;  3RIB A;  3KMT A;  3RAY A;  5JIY A;  3RU0 A;  5EX0 A;  3N71 A;  2IGQ A;  3OOI A;  1PEG A;  3TG4 A;  3F9X A;  5JHN A;  1ZKK A;  1XQH A;  3F9Y A;  3IHX A;  4AU7 A;  3S7F A;  5EX3 A;  5LSZ A;  3SWC A;  4O30 A;  3QWP A;  4H12 A;  4NJ5 A;  4J7F A;  5T0K A;  4J8O A;  3DB5 A;  5F6L A;  3F9Z A;  5JJ0 A;  3OS5 A;  3CBO A;  4IJD A;  5F59 A;  5TTF A;  4RZ0 A;  4YPA A;  2R3A A;  3OXG A;  4FMU A;  5EG2 A;  1H3I A;  3BO5 A;  4YPU A;  5JIN A;  3S7B A;  4QEO A;  5ARG A;  5CPR B;  3FPD A;  3OXL A;  4YND A;  3SW9 A;  5KJK A;  4JDS A;  4QEP A;  4LDG A;  3RQ4 A;  1ML9 A;  3OPE A;  3DAL A;  2RFI A;  2W5Y A;  3M59 A;  4WUY A;  3RJW A;  3M56 A;  4E47 A;  2F69 A;  2O8J A;  1MVH A;  4YNP A;  4J7I A;  3TG5 A;  3M55 A;  5KJL A;  1MT6 A;  5F6K C;  5AYF A;  4MI0 A;  1O9S A;  5KJM A;  4JLG A;  5TH7 A;  3S7J A;  5F5E A;  4IJ8 A;  3M5A A;  1MVX A;  3PDN A;  3K5K A;  3CBM A;  4YPE A;  5HQ8 A;  3M57 A;  5T5G A;  4NVQ A;  5T0M A;  3VUZ A;  3F9W A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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